Expert Review of Endocrinology & Metabolism最新文献

Plasma vitamin D status and its association with biochemical, clinical and humanistic outcomes in diabetic foot infection patients: a prospective observational study in a tertiary healthcare facility.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-04-09 DOI: 10.1080/17446651.2025.2480374

Shilia Jacob Kurian, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Sunil Krishna M, Vijayanarayana Kunhikatta, Sonal Sekhar Miraj

{"title":"Plasma vitamin D status and its association with biochemical, clinical and humanistic outcomes in diabetic foot infection patients: a prospective observational study in a tertiary healthcare facility.","authors":"Shilia Jacob Kurian, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Sunil Krishna M, Vijayanarayana Kunhikatta, Sonal Sekhar Miraj","doi":"10.1080/17446651.2025.2480374","DOIUrl":"https://doi.org/10.1080/17446651.2025.2480374","url":null,"abstract":"Background: The study aimed to determine the association of vitamin D3 status with biochemical, clinical, and quality of life (QoL) in diabetic foot infection (DFI) patients.Research design and methods: A longitudinal study was conducted in a tertiary care hospital. Baseline biochemical (glycemic, renal, plasma vitamin D3), clinical, and QoL data of the DFI patients were collected. Patients were followed up with over the telephone for four months to assess clinical outcomes (healed/not healed). A subgroup analysis was performed to investigate the effect of vitamin D3 supplementation.Results: Eighty-nine DFI patients were enrolled, with a median age of 55 years and a male predominance (89.9%). A significant association between vitamin D3 levels and clinical outcome was not observed (p = 0.66). A moderate correlation was observed with the neutrophil-lymphocyte ratio (r = 0.24, p = 0.02). Regarding QoL, emotions (domain) were significantly associated with vitamin D3 levels (p < 0.01). The subgroup analysis showed that vitamin D3 supplements did not affect the clinical outcome.Conclusion: The plasma vitamin D3 levels and vitamin D3 supplements do not significantly affect the biochemical, clinical, and humanistic outcomes, indicating vitamin D3 did not have a positive effect on DFI patients.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-7"},"PeriodicalIF":2.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-acting growth hormone in the treatment of children with growth hormone deficiency.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-31 DOI: 10.1080/17446651.2025.2486067

Lorenzo Iughetti, Anna Insalaco, Barbara Predieri, Laura Lucaccioni

{"title":"Long-acting growth hormone in the treatment of children with growth hormone deficiency.","authors":"Lorenzo Iughetti, Anna Insalaco, Barbara Predieri, Laura Lucaccioni","doi":"10.1080/17446651.2025.2486067","DOIUrl":"https://doi.org/10.1080/17446651.2025.2486067","url":null,"abstract":"Introduction: The introduction of long-acting formulations in recent years is changing the landscape of growth hormone (GH) therapy. Daily recombinant human GH (rhGH) has been the treatment of choice for children and adults with GH deficiency (GHD), since its approval in 1985. However, decreasing adherence to treatment over time has been identified as a cause of the decline in rhGH efficacy, leading to significant efforts to develop long-acting rhGH (LAGH) formulations.Areas covered: A comprehensive analysis of the literature was conducted to evaluate their mechanism of action, pharmacokinetics, pharmacodynamics, efficacy, safety profile, and administration route. The review focuses on the LAGH approved from both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of pediatric growth hormone deficiency (PGHD): Lonapegsomatropin, Somatrogon and Somapacitan. We aim to facilitate evidence-based clinical decisions by analyzing the available data on the three LAGH formulations.Expert opinion: Even if current evidence suggests a non-inferiority of all the three LAGH formulations when compared to daily rhGH, long-term concerns persist regarding the non-physiological GH profile associated with LAGH, characterized by weekly instead of daily peaks. Further research and real-life studies are required to better define the long-term efficacy of these formulations.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-18"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the controversies of adult growth hormone deficiency diagnosis.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-31 DOI: 10.1080/17446651.2025.2480699

Daniela Cuboni, Luigi Simone Aversa, Silvia Grottoli, Ezio Ghigo, Valentina Gasco

{"title":"An overview of the controversies of adult growth hormone deficiency diagnosis.","authors":"Daniela Cuboni, Luigi Simone Aversa, Silvia Grottoli, Ezio Ghigo, Valentina Gasco","doi":"10.1080/17446651.2025.2480699","DOIUrl":"https://doi.org/10.1080/17446651.2025.2480699","url":null,"abstract":"Introduction: Growth hormone (GH) not only drives growth but also has significant metabolic, structural, and quality-of-life impacts. While GH deficiency (GHD) in childhood impairs growth, in adulthood, it leads to metabolic syndrome and multisystem functional abnormalities, collectively termed adult GHD syndrome. Despite being recognized for decades, adult GHD syndrome continues to pose diagnostic and therapeutic challenge.Areas covered: The aim of this review is to analyze the main controversies that persist in diagnosing adult GHD more than 30 years after the initial studies demonstrating the existence of GHD syndrome in adulthood.Expert opinion: The only reliable method for diagnosing adult GHD is demonstrating the failure of GH levels to rise above a specific threshold following pharmacological stimulation tests. Various tests are available, and the choice of the most appropriate one depends on the clinical context, the presence of potential contraindications, and the availability of specific pharmacological agents. It is also important to note that the reproducibility of some stimulation tests for diagnosing adult GHD has been questioned. The GH cutoff values considered diagnostic for GHD differ depending on the test used, are significantly influenced by the individual's body composition and age as well as by assay method employed.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of mild autonomous cortisol secretion and proposed interventions. 轻度自主皮质醇分泌的影响和干预建议。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-28 DOI: 10.1080/17446651.2025.2480704

María Bernarda Iriarte-Durán, Sara Donato, Aura Herrera, Arturo Vega, José María Jiménez Casinello, Mónica Marazuela, Marta Araujo-Castro

{"title":"The impact of mild autonomous cortisol secretion and proposed interventions.","authors":"María Bernarda Iriarte-Durán, Sara Donato, Aura Herrera, Arturo Vega, José María Jiménez Casinello, Mónica Marazuela, Marta Araujo-Castro","doi":"10.1080/17446651.2025.2480704","DOIUrl":"https://doi.org/10.1080/17446651.2025.2480704","url":null,"abstract":"Introduction: Mild autonomous cortisol secretion (MACS) is the most common hormonal alteration in patients with adrenal incidentalomas (AIs). Given its prevalence and associated adverse outcomes, reviewing its impact and interventions is essential.Areas covered: In this article, we provide a comprehensive review on the diagnosis of MACS, the cardiometabolic burden associated with MACS and on its surgical and medical treatment. The diagnosis of MACS requires three criteria: hormonal evidence of hypercortisolism, the absence of typical Cushing's syndrome signs, and the presence of an AI. The most recommended test for MACS diagnosis is the 1 mg dexamethasone suppression test. There is plenty of evidence of the detrimental effect of MACS, including an increased risk of diabetes, hypertension, dyslipidemia and all-cause mortality. Surgery should be considered for patients with significant comorbidities and has been shown to significantly improve anthropometric variables, hyperglycemia and blood pressure. Medical therapy to lower cortisol offers an effective alternative, particularly for patients with bilateral AI, when surgery is contraindicated, or the patient declines surgery.Expert opinion: Based on our expert opinion, steroid profiling has the potential to become the gold standard for MACS diagnosis, and further studies should identify which patients benefit most from specific treatment to guiding evidence-based recommendations.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-16"},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperglycemia is associated with poorer cognitive performance in a cohort of middle-aged people in Qatar: a cross-sectional study. 卡塔尔中年人群的高血糖与认知能力较差有关：一项横断面研究。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-19 DOI: 10.1080/17446651.2025.2473407

Ashraf I Ahmed, Mohannad Natheef AbuHaweeleh, Aya Abdelhamid, Yazan Al-Dali, Hissa Al-Suwaidi, Yousef Khaled, Tawanda Chivese, Laiche Djouhri

{"title":"Hyperglycemia is associated with poorer cognitive performance in a cohort of middle-aged people in Qatar: a cross-sectional study.","authors":"Ashraf I Ahmed, Mohannad Natheef AbuHaweeleh, Aya Abdelhamid, Yazan Al-Dali, Hissa Al-Suwaidi, Yousef Khaled, Tawanda Chivese, Laiche Djouhri","doi":"10.1080/17446651.2025.2473407","DOIUrl":"10.1080/17446651.2025.2473407","url":null,"abstract":"Background: Diabetes mellitus (DM) prevalence in Qatar is among the highest worldwide. DM has been shown to be associated with reduced performance on numerous domains of cognitive function in elderly population. Here, we sought to determine whether such association also exists in a middle-aged cohort.Research design and methods: A cross-sectional study was conducted using data from 981 participants aged 40-65 years from the Qatar Biobank. We analyzed glycemic indices: HbA1c, serum glucose, insulin levels, waist circumference, and waist-hip ratio. Cognitive function was assessed using two domains of CANTAB: the paired episodic memory (visual memory) and reaction time (motor and mental speed).Results: We found significant associations between DM and cognitive impairment. Poor reaction speed was linked to DM (beta 36.80, P < 0.01), higher HbA1c levels (beta 10.73, P < 0.05), larger waist circumference (beta 1.70, P < 0.001), and higher waist-to-hip ratio (beta 252.56, P ≤ 0.01). Poor memory performance was also associated with increased waist circumference and waist-to-hip ratio.Conclusion: The negative association between DM, its biomarkers, and cognitive impairment reported previously in elderly populations also exists in middle-aged individuals. Further research is needed to explore the causality and impact of dysglycemia on other cognitive domains.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety and depression among adolescents and young adults with thyroid function disorders: a cross-sectional study.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-19 DOI: 10.1080/17446651.2025.2480693

Urooj Lal Rehman, Maliha Khalid, Marium Fatima, Muhammad Saad Khan, Muhammad Tarish Abro, Aminath Waafira

{"title":"Anxiety and depression among adolescents and young adults with thyroid function disorders: a cross-sectional study.","authors":"Urooj Lal Rehman, Maliha Khalid, Marium Fatima, Muhammad Saad Khan, Muhammad Tarish Abro, Aminath Waafira","doi":"10.1080/17446651.2025.2480693","DOIUrl":"https://doi.org/10.1080/17446651.2025.2480693","url":null,"abstract":"Background: Anxiety and depression are significant mental health issues affecting adolescents globally. Moreover, Thyroid disorders frequently coexist with anxiety and depression, leading to overlapping symptoms that complicate diagnosis and treatment. The objective of this study is to determine the prevalence of anxiety and depression among adolescents and young adults with thyroid functional disorders and their associated factors.Research design and method: A cross-sectional study was conducted at the Department of endocrinology, from (June to August) 2024. Variables included were patient demographics such as gender, age, occupation etc. For anxiety assessment: Beck Anxiety Inventory (BAI) was used. For depression assessment: Beck Depression Inventory (BDI) was used.Result: In patients with hyperthyroidism, severe anxiety and depression are strongly associated with common symptoms like tremors, difficulty sleeping, and frequent bowel movements (p < 0.05). In hypothyroidism, severe anxiety and depression is also prevalent, especially with symptoms like constipation, forgetfulness, and muscle weakness.Conclusion: Our study concluded that the mental health of adolescents and young adults is influenced by factors such as age, education, employment status, and thyroid function disorders - hypothyroidism and hyperthyroidism.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway. 肥胖和阻塞性睡眠呼吸暂停严重程度中 SH2B1 基因变异的病例对照研究：瘦素信号通路中的遗传风险因素。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-19 DOI: 10.1080/17446651.2025.2478068

Serkan Kuccukturk, Sebnem Yosunkaya, Mehmet Ali Karaselek, Sennur Demirel, Hasibe Vural

{"title":"A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway.","authors":"Serkan Kuccukturk, Sebnem Yosunkaya, Mehmet Ali Karaselek, Sennur Demirel, Hasibe Vural","doi":"10.1080/17446651.2025.2478068","DOIUrl":"https://doi.org/10.1080/17446651.2025.2478068","url":null,"abstract":"Background: Obstructive sleep apnea (OSA) is a common sleep disorder, frequently observed in obese individuals, with shared mechanisms involving leptin and its receptor, which regulate appetite and energy expenditure. SH2B1 is a key enhancer of signaling in the leptin receptor pathway. This study aimed to investigate the association between SH2B1 variants and OSA.Research design and methods: This case-control study included 160 male patients with OSA and 76 healthy controls, stratified into subgroups based on BMI (≤25 kg/m2 and ≥ 30 kg/m2). Polysomnography and anthropometric measurements were performed, and genotyping of three SH2B1 variants (rs7498665, rs4788102, and rs7359397) was conducted.Results: Mutant genotypes of all three SH2B1 variants were significantly associated with higher BMI. Additionally, normal genotypes of rs4788102 and rs7359397 were associated with higher apnea-hypopnea index (AHI) values, indicating a potential risk for OSA.Conclusion: The findings suggest that while SH2B1 variants are strongly associated with BMI, specific normal genotypes may independently contribute to OSA risk by increasing AHI values.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible attenuation of gout risk by SGLT-2 inhibitors in patients using thiazide and loop diuretics.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-15 DOI: 10.1080/17446651.2025.2480695

Kannan Sridharan

引用次数: 0

The application of 3D printing technology in the treatment of diabetic foot ulcers: an integrated strategy for glycemic control and wound care.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-13 DOI: 10.1080/17446651.2025.2467658

Ying-Ju Liao, Chao-Yi Chen, Hsien-Te Lin, Dee Pei, Yao-Jen Liang

{"title":"The application of 3D printing technology in the treatment of diabetic foot ulcers: an integrated strategy for glycemic control and wound care.","authors":"Ying-Ju Liao, Chao-Yi Chen, Hsien-Te Lin, Dee Pei, Yao-Jen Liang","doi":"10.1080/17446651.2025.2467658","DOIUrl":"https://doi.org/10.1080/17446651.2025.2467658","url":null,"abstract":"Introduction: Diabetic foot ulcers (DFUs) are a severe complication of diabetes, often leading to amputation. Hyperglycemia induced nerve and vascular damage significantly increases DFU risk. The advent of 3D printing technology presents a revolutionary concurrently address glycemic control and wound management, potentially improving patient adherence and offering a more holistic treatment strategy.Methods: This article reviews current oral antidiabetic medications and explores the potential of innovative 3D printing technology to develop extended release tablets in two distinct release profiles. Additionally, it investigates the application of this technology in creating novel wound dressing solutions aimed at facilitating DFU healing. .Results: The integration of 3D printing technology enables the production of customized, extended-release oral medications that optimize glycemic control while minimizing fluctuations in blood sugar levels. Furthermore, 3D-printed wound dressings demonstrate promising potentialfor enhancing wound healing by providing personalized structural support and controlled drug delivery.Conclusion: A multidisciplinary approach that integrates advanced wound care and diabetes management is crucial to address the escalating challenges posed by DFUs. Leveraging3D printing technology to develop sustained-release medications and innovative wound dressingsmay significantly improve DFU outcomes and improve the quality of life for individuals with diabetes.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A research-based, current approach to diabetes-related acute foot infections and chronic osteomyelitis.

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-03-04 DOI: 10.1080/17446651.2025.2474110

Javier Aragón-Sánchez, Gerardo Víquez-Molina, Ilker Uçkay, José María Rojas-Bonilla, Benjamin A Lipsky

{"title":"A research-based, current approach to diabetes-related acute foot infections and chronic osteomyelitis.","authors":"Javier Aragón-Sánchez, Gerardo Víquez-Molina, Ilker Uçkay, José María Rojas-Bonilla, Benjamin A Lipsky","doi":"10.1080/17446651.2025.2474110","DOIUrl":"https://doi.org/10.1080/17446651.2025.2474110","url":null,"abstract":"Introduction: Diabetic foot infections (DFIs) and diabetic foot osteomyelitis (DFO) are common and serious complications in patients with diabetes, often leading to severe morbidity (including amputation) and even mortality. Professional footcare, prompt diagnosis and appropriate treatment are crucial to preventing limb loss and improving outcomes in infections.Areas covered: This narrative review addresses the management of all DFIs, including the approach to clinical evaluation, appropriate diagnostic methods, and optimal therapeutic strategies. We specifically address key areas in antibiotic therapy, and surgical interventions and techniques. Based on our literature review and extensive, multidisciplinary experience, we developed a novel treatment flowchart specifically for the management of DFO.Expert opinion: Managing DFIs, including DFO, requires a multidisciplinary approach tailored to each patient's clinical presentation. While antibiotics, surgery, and wound care each play a crucial role, the decision-making process should always consider the infection's severity and chronicity. Our proposed flowchart for DFO management emphasizes the importance of logically-sequenced, easy to apply and tailored interventions to prevent unnecessary amputations and improve outcomes. Further research is needed to further refine this flowchart in clinical practice and demonstrate its effectiveness.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-15"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0