Expert Review of Endocrinology & Metabolism最新文献

Regional burden, trends, and future projections of chronic kidney disease due to type 2 diabetes mellitus in South Asia: insights from the global burden of disease study (1990-2021) and ARIMA forecasting. 南亚2型糖尿病引起的慢性肾脏疾病的区域负担、趋势和未来预测：来自全球疾病负担研究（1990-2021）和ARIMA预测的见解

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-12 DOI: 10.1080/17446651.2025.2502620

Lovely Jain, Mahalaqua Nazli Khatib, Rangaswamy Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, Edward Mawejje, Sakshi Pandey, Manvinder Brar, Ganesh Bushi, Rachana Mehta, Sanjit Sah, Prakasini Satapathy, Shailesh Kumar Samal

{"title":"Regional burden, trends, and future projections of chronic kidney disease due to type 2 diabetes mellitus in South Asia: insights from the global burden of disease study (1990-2021) and ARIMA forecasting.","authors":"Lovely Jain, Mahalaqua Nazli Khatib, Rangaswamy Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, Edward Mawejje, Sakshi Pandey, Manvinder Brar, Ganesh Bushi, Rachana Mehta, Sanjit Sah, Prakasini Satapathy, Shailesh Kumar Samal","doi":"10.1080/17446651.2025.2502620","DOIUrl":"https://doi.org/10.1080/17446651.2025.2502620","url":null,"abstract":"Background: Chronic kidney disease (CKD) due to Type 2Diabetes Mellitus (T2DM) is an increasing health burden in South Asia. This study evaluates the burden, trends, and future projections of CKD from 1990-2021 using Global Burden of Disease (GBD) data and ARIMA modeling.Research design and methods: We analyzed age-standardized rates (ASR) for prevalence, incidence, mortality, and DALYs of CKD due to T2DM in South Asia(India, Pakistan, Bangladesh, Bhutan, Nepal). Join point regression and ARIMAmodels were applied for trend analysis and projections.Results: From 1990 to 2021, prevalence decreased slightly (e.g. India: 5.4% to 5.2%), while mortality increased (e.g.Pakistan: 33.7 to 42.1 per 100,000). Incidence increased across all countries, with Nepal (1.3% increase) and Bhutan (1.7% increase) showing the highest growth. Projections indicate a continued rise in CKD burden, especially inNepal and India.Conclusion: CKD due to T2DM is increasing, emphasizing the need for targeted interventions.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperglycemia is associated with poorer cognitive performance in a cohort of middle-aged people in Qatar: a cross-sectional study. 卡塔尔中年人群的高血糖与认知能力较差有关：一项横断面研究。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/17446651.2025.2473407

Ashraf I Ahmed, Mohannad Natheef AbuHaweeleh, Aya Abdelhamid, Yazan Al-Dali, Hissa Al-Suwaidi, Yousef Khaled, Tawanda Chivese, Laiche Djouhri

{"title":"Hyperglycemia is associated with poorer cognitive performance in a cohort of middle-aged people in Qatar: a cross-sectional study.","authors":"Ashraf I Ahmed, Mohannad Natheef AbuHaweeleh, Aya Abdelhamid, Yazan Al-Dali, Hissa Al-Suwaidi, Yousef Khaled, Tawanda Chivese, Laiche Djouhri","doi":"10.1080/17446651.2025.2473407","DOIUrl":"10.1080/17446651.2025.2473407","url":null,"abstract":"Background: Diabetes mellitus (DM) prevalence in Qatar is among the highest worldwide. DM has been shown to be associated with reduced performance on numerous domains of cognitive function in elderly population. Here, we sought to determine whether such association also exists in a middle-aged cohort.Research design and methods: A cross-sectional study was conducted using data from 981 participants aged 40-65 years from the Qatar Biobank. We analyzed glycemic indices: HbA1c, serum glucose, insulin levels, waist circumference, and waist-hip ratio. Cognitive function was assessed using two domains of CANTAB: the paired episodic memory (visual memory) and reaction time (motor and mental speed).Results: We found significant associations between DM and cognitive impairment. Poor reaction speed was linked to DM (beta 36.80, P < 0.01), higher HbA1c levels (beta 10.73, P < 0.05), larger waist circumference (beta 1.70, P < 0.001), and higher waist-to-hip ratio (beta 252.56, P ≤ 0.01). Poor memory performance was also associated with increased waist circumference and waist-to-hip ratio.Conclusion: The negative association between DM, its biomarkers, and cognitive impairment reported previously in elderly populations also exists in middle-aged individuals. Further research is needed to explore the causality and impact of dysglycemia on other cognitive domains.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"211-219"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-acting growth hormone in the treatment of children with growth hormone deficiency. 长效生长激素治疗儿童生长激素缺乏症。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/17446651.2025.2486067

Lorenzo Iughetti, Anna Insalaco, Barbara Predieri, Laura Lucaccioni

{"title":"Long-acting growth hormone in the treatment of children with growth hormone deficiency.","authors":"Lorenzo Iughetti, Anna Insalaco, Barbara Predieri, Laura Lucaccioni","doi":"10.1080/17446651.2025.2486067","DOIUrl":"10.1080/17446651.2025.2486067","url":null,"abstract":"Introduction: The introduction of long-acting formulations in recent years is changing the landscape of growth hormone (GH) therapy. Daily recombinant human GH (rhGH) has been the treatment of choice for children and adults with GH deficiency (GHD), since its approval in 1985. However, decreasing adherence to treatment over time has been identified as a cause of the decline in rhGH efficacy, leading to significant efforts to develop long-acting rhGH (LAGH) formulations.Areas covered: A comprehensive analysis of the literature was conducted to evaluate their mechanism of action, pharmacokinetics, pharmacodynamics, efficacy, safety profile, and administration route. The review focuses on the LAGH approved from both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of pediatric growth hormone deficiency (PGHD): Lonapegsomatropin, Somatrogon and Somapacitan. We aim to facilitate evidence-based clinical decisions by analyzing the available data on the three LAGH formulations.Expert opinion: Even if current evidence suggests a non-inferiority of all the three LAGH formulations when compared to daily rhGH, long-term concerns persist regarding the non-physiological GH profile associated with LAGH, characterized by weekly instead of daily peaks. Further research and real-life studies are required to better define the long-term efficacy of these formulations.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"169-186"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway. 肥胖和阻塞性睡眠呼吸暂停严重程度中 SH2B1 基因变异的病例对照研究：瘦素信号通路中的遗传风险因素。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/17446651.2025.2478068

Serkan Kuccukturk, Sebnem Yosunkaya, Mehmet Ali Karaselek, Sennur Demirel, Hasibe Vural

{"title":"A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway.","authors":"Serkan Kuccukturk, Sebnem Yosunkaya, Mehmet Ali Karaselek, Sennur Demirel, Hasibe Vural","doi":"10.1080/17446651.2025.2478068","DOIUrl":"10.1080/17446651.2025.2478068","url":null,"abstract":"Background: Obstructive sleep apnea (OSA) is a common sleep disorder, frequently observed in obese individuals, with shared mechanisms involving leptin and its receptor, which regulate appetite and energy expenditure. SH2B1 is a key enhancer of signaling in the leptin receptor pathway. This study aimed to investigate the association between SH2B1 variants and OSA.Research design and methods: This case-control study included 160 male patients with OSA and 76 healthy controls, stratified into subgroups based on BMI (≤25 kg/m2 and ≥ 30 kg/m2). Polysomnography and anthropometric measurements were performed, and genotyping of three SH2B1 variants (rs7498665, rs4788102, and rs7359397) was conducted.Results: Mutant genotypes of all three SH2B1 variants were significantly associated with higher BMI. Additionally, normal genotypes of rs4788102 and rs7359397 were associated with higher apnea-hypopnea index (AHI) values, indicating a potential risk for OSA.Conclusion: The findings suggest that while SH2B1 variants are strongly associated with BMI, specific normal genotypes may independently contribute to OSA risk by increasing AHI values.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"241-248"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma vitamin D status and its association with biochemical, clinical and humanistic outcomes in diabetic foot infection patients: a prospective observational study in a tertiary healthcare facility. 血浆维生素D水平及其与糖尿病足感染患者生化、临床和人文预后的关系：一项三级医疗机构的前瞻性观察研究

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1080/17446651.2025.2480374

Shilia Jacob Kurian, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Sunil Krishna M, Vijayanarayana Kunhikatta, Sonal Sekhar Miraj

{"title":"Plasma vitamin D status and its association with biochemical, clinical and humanistic outcomes in diabetic foot infection patients: a prospective observational study in a tertiary healthcare facility.","authors":"Shilia Jacob Kurian, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Sunil Krishna M, Vijayanarayana Kunhikatta, Sonal Sekhar Miraj","doi":"10.1080/17446651.2025.2480374","DOIUrl":"10.1080/17446651.2025.2480374","url":null,"abstract":"Background: The study aimed to determine the association of vitamin D3 status with biochemical, clinical, and quality of life (QoL) in diabetic foot infection (DFI) patients.Research design and methods: A longitudinal study was conducted in a tertiary care hospital. Baseline biochemical (glycemic, renal, plasma vitamin D3), clinical, and QoL data of the DFI patients were collected. Patients were followed up with over the telephone for four months to assess clinical outcomes (healed/not healed). A subgroup analysis was performed to investigate the effect of vitamin D3 supplementation.Results: Eighty-nine DFI patients were enrolled, with a median age of 55 years and a male predominance (89.9%). A significant association between vitamin D3 levels and clinical outcome was not observed (p = 0.66). A moderate correlation was observed with the neutrophil-lymphocyte ratio (r = 0.24, p = 0.02). Regarding QoL, emotions (domain) were significantly associated with vitamin D3 levels (p < 0.01). The subgroup analysis showed that vitamin D3 supplements did not affect the clinical outcome.Conclusion: The plasma vitamin D3 levels and vitamin D3 supplements do not significantly affect the biochemical, clinical, and humanistic outcomes, indicating vitamin D3 did not have a positive effect on DFI patients.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"233-239"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible attenuation of gout risk by SGLT-2 inhibitors in patients using thiazide and loop diuretics. SGLT-2抑制剂可能降低噻嗪类药物和利尿剂患者痛风风险。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-15 DOI: 10.1080/17446651.2025.2480695

Kannan Sridharan

引用次数: 0

The application of 3D printing technology in the treatment of diabetic foot ulcers: an integrated strategy for glycemic control and wound care. 3D打印技术在糖尿病足溃疡治疗中的应用：血糖控制和伤口护理的综合策略。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.1080/17446651.2025.2467658

Ying-Ju Liao, Chao-Yi Chen, Hsien-Te Lin, Dee Pei, Yao-Jen Liang

{"title":"The application of 3D printing technology in the treatment of diabetic foot ulcers: an integrated strategy for glycemic control and wound care.","authors":"Ying-Ju Liao, Chao-Yi Chen, Hsien-Te Lin, Dee Pei, Yao-Jen Liang","doi":"10.1080/17446651.2025.2467658","DOIUrl":"10.1080/17446651.2025.2467658","url":null,"abstract":"Introduction: Diabetic foot ulcers (DFUs) are a severe complication of diabetes, often leading to amputation. Hyperglycemia induced nerve and vascular damage significantly increases DFU risk. The advent of 3D printing technology presents a revolutionary concurrently address glycemic control and wound management, potentially improving patient adherence and offering a more holistic treatment strategy.Methods: This article reviews current oral antidiabetic medications and explores the potential of innovative 3D printing technology to develop extended release tablets in two distinct release profiles. Additionally, it investigates the application of this technology in creating novel wound dressing solutions aimed at facilitating DFU healing. .Results: The integration of 3D printing technology enables the production of customized, extended-release oral medications that optimize glycemic control while minimizing fluctuations in blood sugar levels. Furthermore, 3D-printed wound dressings demonstrate promising potentialfor enhancing wound healing by providing personalized structural support and controlled drug delivery.Conclusion: A multidisciplinary approach that integrates advanced wound care and diabetes management is crucial to address the escalating challenges posed by DFUs. Leveraging3D printing technology to develop sustained-release medications and innovative wound dressingsmay significantly improve DFU outcomes and improve the quality of life for individuals with diabetes.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"201-209"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the controversies of adult growth hormone deficiency diagnosis. 成人生长激素缺乏症诊断争议综述。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1080/17446651.2025.2480699

Daniela Cuboni, Luigi Simone Aversa, Silvia Grottoli, Ezio Ghigo, Valentina Gasco

{"title":"An overview of the controversies of adult growth hormone deficiency diagnosis.","authors":"Daniela Cuboni, Luigi Simone Aversa, Silvia Grottoli, Ezio Ghigo, Valentina Gasco","doi":"10.1080/17446651.2025.2480699","DOIUrl":"10.1080/17446651.2025.2480699","url":null,"abstract":"Introduction: Growth hormone (GH) not only drives growth but also has significant metabolic, structural, and quality-of-life impacts. While GH deficiency (GHD) in childhood impairs growth, in adulthood, it leads to metabolic syndrome and multisystem functional abnormalities, collectively termed adult GHD syndrome. Despite being recognized for decades, adult GHD syndrome continues to pose diagnostic and therapeutic challenge.Areas covered: The aim of this review is to analyze the main controversies that persist in diagnosing adult GHD more than 30 years after the initial studies demonstrating the existence of GHD syndrome in adulthood.Expert opinion: The only reliable method for diagnosing adult GHD is demonstrating the failure of GH levels to rise above a specific threshold following pharmacological stimulation tests. Various tests are available, and the choice of the most appropriate one depends on the clinical context, the presence of potential contraindications, and the availability of specific pharmacological agents. It is also important to note that the reproducibility of some stimulation tests for diagnosing adult GHD has been questioned. The GH cutoff values considered diagnostic for GHD differ depending on the test used, are significantly influenced by the individual's body composition and age as well as by assay method employed.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"187-200"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients. 糖尿病和HbA1c作为COVID-19住院患者死亡率的预测因子

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1080/17446651.2025.2469627

Praveen Gupta, Sandeep Bansal, Ira Balakrishnan, Anunay Gupta

{"title":"Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients.","authors":"Praveen Gupta, Sandeep Bansal, Ira Balakrishnan, Anunay Gupta","doi":"10.1080/17446651.2025.2469627","DOIUrl":"10.1080/17446651.2025.2469627","url":null,"abstract":"Background: The role of diabetes mellitus (DM) in hospitalized COVID-19 patients and of HbA1c in hospitalized COVID-19 patients with DM were not studied adequately in the past.Research design and methods: It was a retrospective cohort study. In this study, data from 305 hospitalized COVID-19 patients was analyzed. The study objective was to determine the association of DM with in-hospital mortality in COVID-19 patients. Another study objective was to determine the association of HbA1c with mortality in COVID-19 patients with DM.Results: In this retrospective study, DM was present in 41.3% (126/305) of the study population. The multivariate Cox regression analysis showed a significant association between DM and mortality (adjusted hazard ratio (aHR): 2.116, 95% CI: 1.088-4.116, p = 0.027). The median HbA1c in diabetic patients was 8.9% (7.5-11.0). HbA1c was found to be associated with mortality in diabetic patients in the multivariate cox-regression analysis (aHR:1.272, 95% CI: 1.028-1.574, p = 0.027). The multivariate Cox regression analysis also showed the association of HbA1c (10.5%≤HbA1c > 10.5%) as a dichotomous variable with in-hospital mortality (aHR: 2.53, 95% CI: 2.606-194.81, p = 0.005) in diabetic patients.Conclusions: DM was independently associated with mortality in hospitalized COVID-19 patients in the multivariate analysis. In COVID-19 patients with DM, HbA1c was associated with mortality as a continuous and dichotomous variable in the multivariate analysis.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"221-232"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MAFLD vs. MASLD: a year in review. MAFLD vs. MASLD：一年的回顾。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-04-16 DOI: 10.1080/17446651.2025.2492767

Mingqian Jiang, Amna Subhan Butt, Ian Homer Cua, Ziyan Pan, Said A Al-Busafi, Nahum Méndez-Sánchez, Mohammed Eslam

{"title":"MAFLD vs. MASLD: a year in review.","authors":"Mingqian Jiang, Amna Subhan Butt, Ian Homer Cua, Ziyan Pan, Said A Al-Busafi, Nahum Méndez-Sánchez, Mohammed Eslam","doi":"10.1080/17446651.2025.2492767","DOIUrl":"https://doi.org/10.1080/17446651.2025.2492767","url":null,"abstract":"Introduction: In 2023, metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced following metabolic dysfunction-associated fatty liver disease (MAFLD). Both aim to address the limitations of nonalcoholic fatty liver disease (NAFLD). This review analyzes the similarities and differences between MAFLD and MASLD, focusing on their impacts on epidemiology, diagnosis, stigma, and related liver diseases.Areas covered: Current evidence suggests that MAFLD criteria effectively identify individuals at higher risk through a good balance of sensitivity and specificity. Moreover, MAFLD is a more generalizable term that is easily understood globally.Expert opinion: The transition from NAFLD to MAFLD and MASLD marks a significant advance in understanding fatty liver disease within hepatology. MAFLD identifies a homogeneous cohort of patients with fatty liver due to metabolic dysfunction and provides a valuable framework for holistic, patient-centered management strategies that consider various contributing factors to improve health outcomes.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0