Expert Review of Endocrinology & Metabolism最新文献

The forgotten - overcoming challenges in diabetes care for marginalized populations. 被遗忘者——克服边缘化人群糖尿病护理中的挑战。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-02 DOI: 10.1080/17446651.2025.2526200

Maria S Martinez-Cruz, Neesha Namasingh, Anastasia-Stefania Alexopoulos, Bryan C Batch, Matthew J Crowley, Hayden B Bosworth

{"title":"The forgotten - overcoming challenges in diabetes care for marginalized populations.","authors":"Maria S Martinez-Cruz, Neesha Namasingh, Anastasia-Stefania Alexopoulos, Bryan C Batch, Matthew J Crowley, Hayden B Bosworth","doi":"10.1080/17446651.2025.2526200","DOIUrl":"https://doi.org/10.1080/17446651.2025.2526200","url":null,"abstract":"Introduction: Diabetes disproportionately affects marginalized populations, leading to poorer glycemic control, higher complications, and reduced quality of life. Unequal access to care, mediated by multiple social determinants of health (SDoH), further exacerbates these risks. Addressing SDoH is crucial to mitigate health disparities and downstream impacts on the United States (U.S.) population and healthcare system.Areas covered: This review explores SDoH that disproportionately affect marginalized communities, including socio-economic (SE), geographic, cultural and linguistic, health literacy-related, psychologic, and systemic barriers to equitable diabetes care. We also explore evidence-based care strategies such as telehealth, social media and internet-based education strategies, integration of community health workers (CHW), integrated care models and policy changes.Expert opinion: While small-scale interventions have demonstrated success in overcoming challenges in diabetes care for marginalized populations, significant research gaps remain. Studies focusing on long-term outcomes and addressing the root causes of disparities tied to SDoH are urgently needed. Furthermore, rather than merely characterizing SDoH, researchers and clinicians must actively address them at the patient, provider, and system levels. Advancing diabetes care and reducing disparities requires equity-focused policies, inclusive research, and culturally tailored interventions. Without systemic reforms, however, these advancements risk perpetuating existing inequalities.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-17"},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota alterations and their role in the pathophysiology of obesity following bariatric surgery. 减肥手术后肠道微生物群的改变及其在肥胖病理生理中的作用。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-06-03 DOI: 10.1080/17446651.2025.2512551

Bas Voermans, Victor Gerdes, Max Nieuwdorp

{"title":"Gut microbiota alterations and their role in the pathophysiology of obesity following bariatric surgery.","authors":"Bas Voermans, Victor Gerdes, Max Nieuwdorp","doi":"10.1080/17446651.2025.2512551","DOIUrl":"10.1080/17446651.2025.2512551","url":null,"abstract":"Introduction: Obesity is a global epidemic associated with significant health risks, including type 2 diabetes, cardiovascular diseases, and metabolic disorders. Bariatric surgery remains the gold standard for achieving significant and sustained weight loss. This narrative review was created using literature searches in PubMed, Web of Science, and Scopus.Areas covered: Bariatric surgery induces shifts in gut microbiota composition, with changes in alpha and beta diversity and alters microbial phyla, such as Bacillota, Bacteroidota, Actinomycetota, Pseudomonadota, and Verrucomicrobiota. Genera and species belonging to these groups that have been associated with the pathophysiology of obesity are reported altered as well. These microbial changes, particularly after Roux-en-Y gastric bypass surgery, are generally linked to cardiometabolic improvements to gut hormone profiles and bile acid metabolism.Expert opinion: This review focuses on the changes in gut microbiota following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), highlighting longitudinal human studies. Despite conflicting results, some genera, such as Veillonella, Streptococcus, and Akkermansia muciniphila, show consistent increases post-surgery and may serve as markers of metabolic improvements. The predominance of facultative anaerobes suggests a shift in the gut environment post-surgery. These findings are mainly associations and could be further developed into treatment with the use of next-generation probiotics.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"291-305"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety and depression among adolescents and young adults with thyroid function disorders: a cross-sectional study. 患有甲状腺功能障碍的青少年和年轻人的焦虑和抑郁：一项横断面研究。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-03-19 DOI: 10.1080/17446651.2025.2480693

Urooj Lal Rehman, Maliha Khalid, Marium Fatima, Muhammad Saad Khan, Muhammad Tarish Abro, Aminath Waafira

{"title":"Anxiety and depression among adolescents and young adults with thyroid function disorders: a cross-sectional study.","authors":"Urooj Lal Rehman, Maliha Khalid, Marium Fatima, Muhammad Saad Khan, Muhammad Tarish Abro, Aminath Waafira","doi":"10.1080/17446651.2025.2480693","DOIUrl":"10.1080/17446651.2025.2480693","url":null,"abstract":"Background: Anxiety and depression are significant mental health issues affecting adolescents globally. Moreover, Thyroid disorders frequently coexist with anxiety and depression, leading to overlapping symptoms that complicate diagnosis and treatment. The objective of this study is to determine the prevalence of anxiety and depression among adolescents and young adults with thyroid functional disorders and their associated factors.Research design and method: A cross-sectional study was conducted at the Department of endocrinology, from (June to August) 2024. Variables included were patient demographics such as gender, age, occupation etc. For anxiety assessment: Beck Anxiety Inventory (BAI) was used. For depression assessment: Beck Depression Inventory (BDI) was used.Result: In patients with hyperthyroidism, severe anxiety and depression are strongly associated with common symptoms like tremors, difficulty sleeping, and frequent bowel movements (p < 0.05). In hypothyroidism, severe anxiety and depression is also prevalent, especially with symptoms like constipation, forgetfulness, and muscle weakness.Conclusion: Our study concluded that the mental health of adolescents and young adults is influenced by factors such as age, education, employment status, and thyroid function disorders - hypothyroidism and hyperthyroidism.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"279-289"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MAFLD vs. MASLD: a year in review. MAFLD vs. MASLD：一年的回顾。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-04-16 DOI: 10.1080/17446651.2025.2492767

Mingqian Jiang, Amna Subhan Butt, Ian Homer Cua, Ziyan Pan, Said A Al-Busafi, Nahum Méndez-Sánchez, Mohammed Eslam

{"title":"MAFLD vs. MASLD: a year in review.","authors":"Mingqian Jiang, Amna Subhan Butt, Ian Homer Cua, Ziyan Pan, Said A Al-Busafi, Nahum Méndez-Sánchez, Mohammed Eslam","doi":"10.1080/17446651.2025.2492767","DOIUrl":"10.1080/17446651.2025.2492767","url":null,"abstract":"Introduction: In 2023, metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced following metabolic dysfunction-associated fatty liver disease (MAFLD). Both aim to address the limitations of nonalcoholic fatty liver disease (NAFLD). This review analyzes the similarities and differences between MAFLD and MASLD, focusing on their impacts on epidemiology, diagnosis, stigma, and related liver diseases.Areas covered: Current evidence suggests that MAFLD criteria effectively identify individuals at higher risk through a good balance of sensitivity and specificity. Moreover, MAFLD is a more generalizable term that is easily understood globally.Expert opinion: The transition from NAFLD to MAFLD and MASLD marks a significant advance in understanding fatty liver disease within hepatology. MAFLD identifies a homogeneous cohort of patients with fatty liver due to metabolic dysfunction and provides a valuable framework for holistic, patient-centered management strategies that consider various contributing factors to improve health outcomes.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"267-278"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of levothyroxine monotherapy versus combination therapy on quality of life and patient satisfaction. 左旋甲状腺素单药治疗与联合治疗对生活质量和患者满意度的影响。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1080/17446651.2025.2492789

Jacqueline Jonklaas

{"title":"The effects of levothyroxine monotherapy versus combination therapy on quality of life and patient satisfaction.","authors":"Jacqueline Jonklaas","doi":"10.1080/17446651.2025.2492789","DOIUrl":"10.1080/17446651.2025.2492789","url":null,"abstract":"Introduction: Hypothyroidism is a relatively common condition, which generally cannot be reversed. Hypothyroid individuals are dependent on provision of exogenous thyroid hormone as a lifetime therapy. Levothyroxine therapy provides satisfactory treatment for most. However, a subset of patients are not restored to their baseline quality of life.Areas covered: As discussed here, a number of solutions have been tried, including addressing accompanying conditions, rigorous titration of therapy, and combination therapy with levothyroxine and liothyronine. The latter has limited success with improving quality of life, but does appear to be associated with patient preference. The discrepancy between quality of life and patient preference may be important to understanding the nuances of successful hypothyroidism treatment.Expert opinion: Future efforts to improve hypothyroidism therapy could tease out which are the specific subset of patients who benefit from combination therapy, such as those who have unresolved symptoms attributable to hypothyroidism at baseline and those with genetic polymorphisms that might impair thyroid hormone delivery to tissues. Better understanding of the drivers of patient preference for combination therapy should also be revealing. A future goal is to prevent autoimmune hypothyroidism from developing and to treat hypothyroidism completely by generating fully functioning thyroid follicles from stem cells.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"317-325"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of Beinaglutide on obesity and related factors: a systematic review and meta-analysis of randomized controlled trials. 贝那鲁肽对肥胖及相关因素的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-04-11 DOI: 10.1080/17446651.2025.2491404

Sepideh Poshtdar, Pejman Rohani, Amirali Ahrabi, Nekoo Panahi, Mohammad Hassan Sohouli

{"title":"The effects of Beinaglutide on obesity and related factors: a systematic review and meta-analysis of randomized controlled trials.","authors":"Sepideh Poshtdar, Pejman Rohani, Amirali Ahrabi, Nekoo Panahi, Mohammad Hassan Sohouli","doi":"10.1080/17446651.2025.2491404","DOIUrl":"10.1080/17446651.2025.2491404","url":null,"abstract":"Background: Considering the important role of obesity and related factors in different societies on increasing the burden of non-communicable diseases, in this review we will investigate the possible effects of Beinaglutide on these risk factors.Research design and methods: In order to identify all randomized controlled trials that investigated the effects of Beinaglutide on cardiometabolic factors, a systematic search was conducted in the original databases using predefined keywords until July 2024. The pooled weighted mean difference (WMD) and 95% confidence intervals were computed using the random-effects model.Results: A quantitative meta-analysis results from seven studies with 872 participants showed that Beinaglutide has a significant lowering effect on weight (WMD: -3.74 kg; 95% CI: -5.03, -2.45), body mass index (BMI) (WMD:-1.64 kg/m2; 95% CI: -2.10, -1.17), waist circumference (WC) (WMD: -3.19 cm; 95% CI: -4.65 to -1.73), triglyceride (TG) levels (WMD: -0.14 mmol/l with; 95% CI: -0.25, -0.04), and systolic blood pressure (SBP) (WMD: -1.76 mm/Hg; 95% CI: -2.61, -0.91). In addition, body weight loss was greater in doses < 0.4 mg compared to doses ≥ 0.4 mg.Conclusions: The results of this meta-analysis show that Beinaglutide is effective in reducing parameters related to obesity, TG as well as SBP.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"307-316"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E-cadherin as a surrogate marker of epithelial-to-mesenchymal transition for detection of diabetic nephropathy and subclinical atherosclerosis among children and adolescents with type 1 diabete. e -钙粘蛋白作为1型糖尿病儿童和青少年糖尿病肾病和亚临床动脉粥样硬化检测中上皮-间质转化的替代标志物

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-04-13 DOI: 10.1080/17446651.2025.2492762

Yasmine Ibrahim Elhenawy, Abeer Ahmed Abdelmaksoud, Eman Abdel Rahman Ismail, Zakaria Mostafa Elashmawy, Dina Ebrahem Sallam

{"title":"E-cadherin as a surrogate marker of epithelial-to-mesenchymal transition for detection of diabetic nephropathy and subclinical atherosclerosis among children and adolescents with type 1 diabete.","authors":"Yasmine Ibrahim Elhenawy, Abeer Ahmed Abdelmaksoud, Eman Abdel Rahman Ismail, Zakaria Mostafa Elashmawy, Dina Ebrahem Sallam","doi":"10.1080/17446651.2025.2492762","DOIUrl":"10.1080/17446651.2025.2492762","url":null,"abstract":"Background: Epithelial-to-mesenchymal transition (EMT) may be involved in the pathogenesis of diabetic nephropathy (DN) among adults with type 2 diabetes. The current study aimed to evaluate the role of E-cadherin as a surrogate marker of EMT among children and adolescent with type 1 diabetes (T1D) and DN and its possible relation to carotid intima media thickness (CIMT).Research design and methods: Sixty participants with T1D were divided equally into two groups based on urinary albumin creatinine ratio (UACR) and compared with 30 healthy controls. Hemoglobin A1c (HbA1c), kidney function tests, serum E-cadherin and CIMT were assessed.Results: E-cadherin levels were significantly lower in patients with microalbuminuria (56.5 ± 15.8 ng/mL) compared with patients with normoalbuminuria (179.8 ± 45.1 ng/mL) and healthy controls (222.5 ± 39.9 ng/mL) (p < 0.001). E-cadherin correlated negatively with HbA1c (r = -0.42, p = 0.001), UACR (r = -0.89, p < 0.001) and CIMT (r = -0.716, p < 0.001). ROC curve analysis showed that the E-cadherin cutoff value 135 ng/mL could detect nephropathy with 96.67% sensitivity and 86.67% specificity. Logistic regression showed that E-cadherin was a significant independent factor for nephropathy.Conclusions: E-cadherin is a potential biomarker reflecting EMT activity in both pathogenesis and progression of DN and subclinical atherosclerosis in pediatric patients with T1D.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"327-333"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of mild autonomous cortisol secretion and proposed interventions. 轻度自主皮质醇分泌的影响和干预建议。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-03-28 DOI: 10.1080/17446651.2025.2480704

María Bernarda Iriarte-Durán, Sara Donato, Aura Herrera, Arturo Vega, José María Jiménez Casinello, Mónica Marazuela, Marta Araujo-Castro

{"title":"The impact of mild autonomous cortisol secretion and proposed interventions.","authors":"María Bernarda Iriarte-Durán, Sara Donato, Aura Herrera, Arturo Vega, José María Jiménez Casinello, Mónica Marazuela, Marta Araujo-Castro","doi":"10.1080/17446651.2025.2480704","DOIUrl":"10.1080/17446651.2025.2480704","url":null,"abstract":"Introduction: Mild autonomous cortisol secretion (MACS) is the most common hormonal alteration in patients with adrenal incidentalomas (AIs). Given its prevalence and associated adverse outcomes, reviewing its impact and interventions is essential.Areas covered: In this article, we provide a comprehensive review on the diagnosis of MACS, the cardiometabolic burden associated with MACS and on its surgical and medical treatment. The diagnosis of MACS requires three criteria: hormonal evidence of hypercortisolism, the absence of typical Cushing's syndrome signs, and the presence of an AI. The most recommended test for MACS diagnosis is the 1 mg dexamethasone suppression test. There is plenty of evidence of the detrimental effect of MACS, including an increased risk of diabetes, hypertension, dyslipidemia and all-cause mortality. Surgery should be considered for patients with significant comorbidities and has been shown to significantly improve anthropometric variables, hyperglycemia and blood pressure. Medical therapy to lower cortisol offers an effective alternative, particularly for patients with bilateral AI, when surgery is contraindicated, or the patient declines surgery.Expert opinion: Based on our expert opinion, steroid profiling has the potential to become the gold standard for MACS diagnosis, and further studies should identify which patients benefit most from specific treatment to guiding evidence-based recommendations.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"251-266"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional burden, trends, and future projections of chronic kidney disease due to type 2 diabetes mellitus in South Asia: insights from the global burden of disease study (1990-2021) and ARIMA forecasting. 南亚2型糖尿病引起的慢性肾脏疾病的区域负担、趋势和未来预测：来自全球疾病负担研究（1990-2021）和ARIMA预测的见解

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1080/17446651.2025.2502620

Lovely Jain, Mahalaqua Nazli Khatib, Rangaswamy Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, Edward Mawejje, Sakshi Pandey, Manvinder Brar, Ganesh Bushi, Rachana Mehta, Sanjit Sah, Prakasini Satapathy, Shailesh Kumar Samal

{"title":"Regional burden, trends, and future projections of chronic kidney disease due to type 2 diabetes mellitus in South Asia: insights from the global burden of disease study (1990-2021) and ARIMA forecasting.","authors":"Lovely Jain, Mahalaqua Nazli Khatib, Rangaswamy Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G V Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, Edward Mawejje, Sakshi Pandey, Manvinder Brar, Ganesh Bushi, Rachana Mehta, Sanjit Sah, Prakasini Satapathy, Shailesh Kumar Samal","doi":"10.1080/17446651.2025.2502620","DOIUrl":"10.1080/17446651.2025.2502620","url":null,"abstract":"Background: Chronic kidney disease (CKD) due to Type 2Diabetes Mellitus (T2DM) is an increasing health burden in South Asia. This study evaluates the burden, trends, and future projections of CKD from 1990-2021 using Global Burden of Disease (GBD) data and ARIMA modeling.Research design and methods: We analyzed age-standardized rates (ASR) for prevalence, incidence, mortality, and DALYs of CKD due to T2DM in South Asia(India, Pakistan, Bangladesh, Bhutan, Nepal). Join point regression and ARIMAmodels were applied for trend analysis and projections.Results: From 1990 to 2021, prevalence decreased slightly (e.g. India: 5.4% to 5.2%), while mortality increased (e.g.Pakistan: 33.7 to 42.1 per 100,000). Incidence increased across all countries, with Nepal (1.3% increase) and Bhutan (1.7% increase) showing the highest growth. Projections indicate a continued rise in CKD burden, especially inNepal and India.Conclusion: CKD due to T2DM is increasing, emphasizing the need for targeted interventions.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"335-343"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of the potential value of treatment targets in obesity management. 肥胖症治疗靶点的潜在价值综述。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2025-06-12 DOI: 10.1080/17446651.2025.2516522

Faisal Almohaileb, Carel W le Roux

{"title":"Review of the potential value of treatment targets in obesity management.","authors":"Faisal Almohaileb, Carel W le Roux","doi":"10.1080/17446651.2025.2516522","DOIUrl":"https://doi.org/10.1080/17446651.2025.2516522","url":null,"abstract":"Introduction: Treatment targets can be considered the threshold where treatments generate optimal health outcomes while causing minimal complications. Treatment targets often uses a surrogate measure for the disease process, but are linked with an important outcome of disease management. Unlike chronic diseases such as type 1 diabetes, type 2 diabetes, hypertension, and dyslipidemia, which have clear treatment targets, obesity management lacks defined therapeutic targets. Insights from other chronic diseases may improve patient outcomes. They guide care, assess therapy response, and reduce complications.Areas covered: This article explores how treatment targets for diabetes, hypertension, and dyslipidemia were developed, drawing on a narrative review of literature from 1950 to 2025 using PubMed and Embase. It examines how similar principles could inform obesity treatment, proposing early hypotheses like BMI ≤ 27 kg/m2 and WHtR < 0.53 that warrant future validation.Expert opinion: Targets in chronic disease care reduce complications. While not yet validated, BMI ≤ 27 kg/m2 and WHtR < 0.53 May serve as early anchors for structured obesity treatment strategies.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-7"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0