Mariana Lourenço, Ana Rita Leite, Patrícia Ferreira, Inês Meira, João Menino, Ana Margarida Lopes, Joana Lagoa, Beatriz Viveiros, Maria João Barbosa, Sílvia Santos Monteiro, Joana Queirós, João Sérgio Neves, Celestino Neves
{"title":"1型糖尿病患者正常范围内甲状腺功能与血糖控制及心血管危险因素的关系","authors":"Mariana Lourenço, Ana Rita Leite, Patrícia Ferreira, Inês Meira, João Menino, Ana Margarida Lopes, Joana Lagoa, Beatriz Viveiros, Maria João Barbosa, Sílvia Santos Monteiro, Joana Queirós, João Sérgio Neves, Celestino Neves","doi":"10.1080/17446651.2025.2532560","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Thyroid hormone (TH) variations, even within the normal range, influence cardiometabolic health. In type 1 diabetes (T1D), optimizing glycemic control and cardiovascular risk is crucial to prevent complications. We aim to explore the association of TH within normal range with cardiometabolic profile in T1D.</p><p><strong>Research design and methods: </strong>Cross-sectional analysis including adult patients with T1D followed at our Endocrinology Department between 2022-2024. We excluded patients with TSH or fT4 outside the reference range. Associations between TH (TSH, fT4, fT3 and fT3/fT4 ratio) and glycemic, anthropometric, and cardiometabolic parameters, were evaluated using linear regression models unadjusted and adjusted for relevant variables. Restricted cubic splines between TH and glycemic control parameters were performed to assess non-linear associations.</p><p><strong>Results: </strong>We included 296 patients (median age 35 years, 42.6% female). Patients with mid-range TSH had better glycemic control, with higher time in range and a lower time above range. Waist circumference and body mass index were negatively associated with fT4, and positively with fT3 and fT3/fT4 ratio. Estimated glomerular filtration rate was negatively associated with TSH and fT4, and positively with fT3 and fT3/fT4.</p><p><strong>Conclusions: </strong>Variations in TH within the normal range were associated with glycemic control and cardiovascular risk factors in T1D.</p>","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"1-11"},"PeriodicalIF":2.8000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of thyroid function within the normal range with glycemic control and cardiovascular risk factors in type 1 diabetes.\",\"authors\":\"Mariana Lourenço, Ana Rita Leite, Patrícia Ferreira, Inês Meira, João Menino, Ana Margarida Lopes, Joana Lagoa, Beatriz Viveiros, Maria João Barbosa, Sílvia Santos Monteiro, Joana Queirós, João Sérgio Neves, Celestino Neves\",\"doi\":\"10.1080/17446651.2025.2532560\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Thyroid hormone (TH) variations, even within the normal range, influence cardiometabolic health. In type 1 diabetes (T1D), optimizing glycemic control and cardiovascular risk is crucial to prevent complications. We aim to explore the association of TH within normal range with cardiometabolic profile in T1D.</p><p><strong>Research design and methods: </strong>Cross-sectional analysis including adult patients with T1D followed at our Endocrinology Department between 2022-2024. We excluded patients with TSH or fT4 outside the reference range. Associations between TH (TSH, fT4, fT3 and fT3/fT4 ratio) and glycemic, anthropometric, and cardiometabolic parameters, were evaluated using linear regression models unadjusted and adjusted for relevant variables. Restricted cubic splines between TH and glycemic control parameters were performed to assess non-linear associations.</p><p><strong>Results: </strong>We included 296 patients (median age 35 years, 42.6% female). Patients with mid-range TSH had better glycemic control, with higher time in range and a lower time above range. Waist circumference and body mass index were negatively associated with fT4, and positively with fT3 and fT3/fT4 ratio. Estimated glomerular filtration rate was negatively associated with TSH and fT4, and positively with fT3 and fT3/fT4.</p><p><strong>Conclusions: </strong>Variations in TH within the normal range were associated with glycemic control and cardiovascular risk factors in T1D.</p>\",\"PeriodicalId\":12107,\"journal\":{\"name\":\"Expert Review of Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Endocrinology & Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/17446651.2025.2532560\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Endocrinology & Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17446651.2025.2532560","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association of thyroid function within the normal range with glycemic control and cardiovascular risk factors in type 1 diabetes.
Background: Thyroid hormone (TH) variations, even within the normal range, influence cardiometabolic health. In type 1 diabetes (T1D), optimizing glycemic control and cardiovascular risk is crucial to prevent complications. We aim to explore the association of TH within normal range with cardiometabolic profile in T1D.
Research design and methods: Cross-sectional analysis including adult patients with T1D followed at our Endocrinology Department between 2022-2024. We excluded patients with TSH or fT4 outside the reference range. Associations between TH (TSH, fT4, fT3 and fT3/fT4 ratio) and glycemic, anthropometric, and cardiometabolic parameters, were evaluated using linear regression models unadjusted and adjusted for relevant variables. Restricted cubic splines between TH and glycemic control parameters were performed to assess non-linear associations.
Results: We included 296 patients (median age 35 years, 42.6% female). Patients with mid-range TSH had better glycemic control, with higher time in range and a lower time above range. Waist circumference and body mass index were negatively associated with fT4, and positively with fT3 and fT3/fT4 ratio. Estimated glomerular filtration rate was negatively associated with TSH and fT4, and positively with fT3 and fT3/fT4.
Conclusions: Variations in TH within the normal range were associated with glycemic control and cardiovascular risk factors in T1D.
期刊介绍：
Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.
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