Expert Review of Endocrinology & Metabolism最新文献_第2页

Epidemiology of post-pancreatitis diabetes mellitus: insights from the COSMOS program. 胰腺炎后糖尿病的流行病学：COSMOS 计划的启示。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI: 10.1080/17446651.2024.2382958

Jaelim Cho, Maxim S Petrov

引用次数: 0

Functional state of the kidneys in patients with acute coronary syndrome against the background of newly identified disorders of carbohydrate metabolism: a multidisciplinary problem. 在新发现的碳水化合物代谢紊乱的背景下，急性冠状动脉综合征患者的肾脏功能状态：一个多学科问题。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-03 DOI: 10.1080/17446651.2024.2363543

Svetlana Kazaryan, Rimma Bazarbekova, Ainur Dossanova, Nazgul Kainarbekova, Aigerim Zhakebayeva

{"title":"Functional state of the kidneys in patients with acute coronary syndrome against the background of newly identified disorders of carbohydrate metabolism: a multidisciplinary problem.","authors":"Svetlana Kazaryan, Rimma Bazarbekova, Ainur Dossanova, Nazgul Kainarbekova, Aigerim Zhakebayeva","doi":"10.1080/17446651.2024.2363543","DOIUrl":"10.1080/17446651.2024.2363543","url":null,"abstract":"Background: Determining the relationship between cardiovascular risks, carbohydrate metabolism disorders, and renal dysfunction can help in creating new tools for their management and for better interaction of specialists in a multidisciplinary team. The purpose of this study was to determine the functional state of the kidneys and carbohydrate metabolism in patients with acute coronary syndrome without a history of such disorders.Methods: 200 patients of the cardiology department of the City Clinical Hospital No. 7 in Almaty were examined using laboratory diagnostics and subsequent statistical data processing.Results: Acute coronary syndrome develops in 63% of cases against the background of previous disorders of carbohydrate metabolism - prediabetes (45.5%) and type 2 diabetes mellitus (17.5%). In this group of patients, in the presence of disorders of carbohydrate metabolism, in all cases, it is accompanied by acute renal damage. It was noted that diabetes mellitus in newly diagnosed patients actually had a certain duration and occurred much earlier than cardiovascular complications - this was evidenced by an increased level of glycated hemoglobin.Conclusions: Such results indicate the need for early diagnosis of cardio-reno-metabolic syndrome in patients with cardiovascular complications, as well as timely administration of drugs that simultaneously have antidiabetic, cardio- and nephroprotective effects.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"437-445"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting hypoglycemia in ICU patients: a machine learning approach. 预测重症监护室患者的低血糖症：一种机器学习方法。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-09-01 Epub Date: 2024-09-16 DOI: 10.1080/17446651.2024.2403039

Reema Karasneh, Sayer Al-Azzam, Karem H Alzoubi, Muna Ebbini, Asma'a Alselwi, Dania Rahhal, Suad Kabbaha, Mamoon A Aldeyab, Aisha F Badr

{"title":"Predicting hypoglycemia in ICU patients: a machine learning approach.","authors":"Reema Karasneh, Sayer Al-Azzam, Karem H Alzoubi, Muna Ebbini, Asma'a Alselwi, Dania Rahhal, Suad Kabbaha, Mamoon A Aldeyab, Aisha F Badr","doi":"10.1080/17446651.2024.2403039","DOIUrl":"10.1080/17446651.2024.2403039","url":null,"abstract":"Background: The current study sets out to develop and validate a robust machine-learning model utilizing electronic health records (EHR) to forecast the risk of hypoglycemia among ICU patients in Jordan.Research design and methods: The present study drew upon a substantial cohort of 13,567 patients admitted 26,248 times to the intensive care unit (ICU) over 10 years from July 2012 to July 2022. The primary outcome of interest was the occurrence of any hypoglycemic episode during the patient's ICU stay. Developing and testing predictor models was conducted using Python machine-learning libraries.Results: A total of 1,896 were eligible to participate in the study, 206 experienced at least one hypoglycemic episode. Eight machine-learning models were trained to predict hypoglycemia. All models showed predicting power with a range of 74.53-99.69 for AUROC. Except for Naive Bayes, the six remaining models performed distinctly better than the basic logistic regression usually used for prediction in epidemiological studies. CatBoost model was consistently the best performer with the highest AUROC (0.99), accuracy and precision, sensitivity and specificity, and recall.Conclusions: We used machine learning to anticipate the likelihood of hypoglycemia, which can significantly decrease hypoglycemia incidents and enhance patient outcomes.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"459-466"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral octreotide capsules for acromegaly treatment: application of clinical trial insights to real-world use. 用于肢端肥大症治疗的口服奥曲肽胶囊：将临床试验见解应用于实际应用。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-06 DOI: 10.1080/17446651.2024.2363540

Maria Fleseriu, Lisa B Nachtigall, Susan L Samson, Shlomo Melmed

{"title":"Oral octreotide capsules for acromegaly treatment: application of clinical trial insights to real-world use.","authors":"Maria Fleseriu, Lisa B Nachtigall, Susan L Samson, Shlomo Melmed","doi":"10.1080/17446651.2024.2363540","DOIUrl":"10.1080/17446651.2024.2363540","url":null,"abstract":"Introduction: Acromegaly is a rare endocrine disorder usually caused by a benign growth hormone‒secreting pituitary adenoma. Surgical adenoma resection is typically the first line of treatment, and medical therapy is used for patients with persistent disease following surgery, for adenoma recurrence, or for patients ineligible for, or declining, surgery. Approved somatostatin receptor ligands (SRLs) have been limited to injectable options, until recently. Oral octreotide capsules (OOC) are the first approved oral SRL for patients with acromegaly.Areas covered: We review published reports and provide case study examples demonstrating practical considerations on the use of OOC. Using two hypothetical case scenarios, we discuss current treatment patterns, breakthrough symptoms and quality of life (QoL), efficacy of SRLs, OOC dose titration, evaluation of OOC treatment response, and incidence and management of adverse events.Expert opinion: OOC are an option for patients with acromegaly including those who experience breakthrough symptoms, who have preference for oral therapies, or other reasons for declining injectable SRLs. OOC have been associated with improved patient-reported QoL measures compared with those reported for lanreotide and octreotide. Continued real-world experience will determine whether OOC, alone or in combination with other therapies, provides further advantages over current injectable acromegaly treatments.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"367-375"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity in type 1 diabetes: an overlooked immune-metabolic issue. 1 型糖尿病患者的肥胖问题：一个被忽视的免疫代谢问题。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI: 10.1080/17446651.2024.2351868

Ernesto Maddaloni, Dario Tuccinardi

引用次数: 0

Per-polyfluoroalkyl substances (PFAS) as thyroid disruptors: is there evidence for multi-transgenerational effects? 作为甲状腺干扰物的全氟烷基物质（PFAS）：是否有证据表明存在多代效应？

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-19 DOI: 10.1080/17446651.2024.2351885

Francesca Coperchini, Marsida Teliti, Alessia Greco, Laura Croce, Mario Rotondi

{"title":"Per-polyfluoroalkyl substances (PFAS) as thyroid disruptors: is there evidence for multi-transgenerational effects?","authors":"Francesca Coperchini, Marsida Teliti, Alessia Greco, Laura Croce, Mario Rotondi","doi":"10.1080/17446651.2024.2351885","DOIUrl":"10.1080/17446651.2024.2351885","url":null,"abstract":"Introduction: The environmental spread of pollutants has led to a persistent exposure of living beings to multiple chemicals, by now become ubiquitous in the surrounding environment. Environmental exposure to these substances has been reported to cause multi- and/or transgenerational health effects. Per- and Polyfluorinated Substances (PFAS) raise great concern, given their known effects both as endocrine disruptors and potential carcinogens. The multi/trans-generational effects of different endocrine disruptors have been investigated by several studies, and harmful effects observed also for PFAS.Areas covered: This review examines the current data on the multi-trans-generational effects of PFAS, with a focus on their impact on the thyroid axis. The aim is to determine if there is evidence of potential multi-trans-generational effects of PFAS on the thyroid and/or if more research is needed.Expert opinion: PFAS exposure impacts thyroid homeostasis and can cross the placental barrier. In addition PFAS have shown multi-transgenerational effects in laboratory experiences and animal models, but thyroid disruptive effects of PFAS were also investigated only in a small number of these studies. Efforts are needed to study the adverse effects of PFAS, as not all PFAS are regulated and removal strategies are still being developed.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"307-315"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal obesity and metabolic (dysfunction) associated fatty liver disease in pregnancy: a comprehensive narrative review. 妊娠期母体肥胖和代谢（功能障碍）相关脂肪肝：综合叙述性综述。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-11 DOI: 10.1080/17446651.2024.2365791

Bianca M Leca, Lukasz Lagojda, Chris Kite, Emmanouil Karteris, Eva Kassi, Harpal S Randeva, Ioannis Kyrou

{"title":"Maternal obesity and metabolic (dysfunction) associated fatty liver disease in pregnancy: a comprehensive narrative review.","authors":"Bianca M Leca, Lukasz Lagojda, Chris Kite, Emmanouil Karteris, Eva Kassi, Harpal S Randeva, Ioannis Kyrou","doi":"10.1080/17446651.2024.2365791","DOIUrl":"10.1080/17446651.2024.2365791","url":null,"abstract":"Introduction: Obesity and metabolic-associated fatty liver disease (MAFLD) during pregnancy constitute significant problems for routine antenatal care, with increasing prevalence globally. Similar to obesity, MAFLD is associated with a higher risk for maternal complications (e.g. pre-eclampsia and gestational diabetes) and long-term adverse health outcomes for the offspring. However, MAFLD during pregnancy is often under-recognized, with limited management/treatment options.Areas covered: PubMed/MEDLINE, EMBASE, and Scopus were searched based on a search strategy for obesity and/or MAFLD in pregnancy to identify relevant papers up to 2024. This review summarizes the pertinent evidence on the relationship between maternal obesity and MAFLD during pregnancy. Key mechanisms implicated in the underlying pathophysiology linking obesity and MAFLD during pregnancy (e.g. insulin resistance and dysregulated adipokine secretion) are highlighted. Moreover, a diagnostic approach for MAFLD diagnosis during pregnancy and its complications are presented. Finally, promising relevant areas for future research are covered.Expert opinion: Research progress regarding maternal obesity, MAFLD, and their impact on maternal and fetal/offspring health is expected to improve the relevant diagnostic methods and lead to novel treatments. Thus, routine practice could apply more personalized management strategies, incorporating individualized algorithms with genetic and/or multi-biomarker profiling to guide prevention, early diagnosis, and treatment.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"335-348"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiology and emerging treatments for familial chylomicronemia syndrome. 家族性乳糜微粒血症综合征的病因和新疗法。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-12 DOI: 10.1080/17446651.2024.2365787

Catherine M Spagnuolo, Robert A Hegele

{"title":"Etiology and emerging treatments for familial chylomicronemia syndrome.","authors":"Catherine M Spagnuolo, Robert A Hegele","doi":"10.1080/17446651.2024.2365787","DOIUrl":"10.1080/17446651.2024.2365787","url":null,"abstract":"Introduction: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive condition. Effective treatment is important as patients are at risk for severe and potentially fatal acute pancreatitis. We review recent developments in pharmacologic treatment for FCS, namely biological inhibitors of apolipoprotein (apo) C-III and angiopoietin-like protein 3 (ANGPTL3).Areas covered: FCS follows a biallelic inheritance pattern in which an individual inherits two pathogenic loss-of-function alleles of one of the five causal genes - LPL (in 60-80% of patients), GPIHBP1, APOA5, APOC2, and LMF1 - leading to the absence of lipolytic activity. Patients present from childhood with severely elevated triglyceride (TG) levels >10 mmol/L. Most patients with severe hypertriglyceridemia do not have FCS. A strict low-fat diet is the current first-line treatment, and existing lipid-lowering therapies are minimally effective in FCS. Apo C-III inhibitors are emerging TG-lowering therapies shown to be efficacious and safe in clinical trials. ANGPTL3 inhibitors, another class of emerging TG-lowering therapies, have been found to require at least partial lipoprotein lipase activity to lower plasma TG in clinical trials. ANGPTL3 inhibitors reduce plasma TG in patients with multifactorial chylomicronemia but not in patients with FCS who completely lack lipoprotein lipase activity.Expert opinion: Apo C-III inhibitors currently in development are promising treatments for FCS.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"299-306"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular imaging of thyroid and parathyroid diseases. 甲状腺和甲状旁腺疾病的分子成像。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1080/17446651.2024.2365776

Petra Petranović Ovčariček, Letizia Calderoni, Alfredo Campenni, Stefano Fanti, Luca Giovanella

{"title":"Molecular imaging of thyroid and parathyroid diseases.","authors":"Petra Petranović Ovčariček, Letizia Calderoni, Alfredo Campenni, Stefano Fanti, Luca Giovanella","doi":"10.1080/17446651.2024.2365776","DOIUrl":"10.1080/17446651.2024.2365776","url":null,"abstract":"Introduction: Molecular imaging of thyroid and parathyroid diseases has changed in recent years due to the introduction of new radiopharmaceuticals and new imaging techniques. Accordingly, we provided an clinicians-oriented overview of such techniques and their indications.Areas covered: A review of the literature was performed in the PubMed, Web of Science, and Scopus without time or language restrictions through the use of one or more fitting search criteria and terms as well as through screening of references in relevant selected papers. Literature up to and including December 2023 was included. Screening of titles/abstracts and removal of duplicates was performed and the full texts of the remaining potentially relevant articles were retrieved and reviewed.Expert opinion: Thyroid and parathyroid scintigraphy remains integral in patients with thyrotoxicosis, thyroid nodules, differentiated thyroid cancer and, respectively, hyperparathyroidism. In the last years positron-emission tomography with different tracers emerged as a more accurate alternative in evaluating indeterminate thyroid nodules [18F-fluorodeoxyglucose (FDG)], differentiated thyroid cancer [124I-iodide, 18F-tetrafluoroborate, 18F-FDG] and hyperparathyroidism [18F-fluorocholine]. Other PET tracers are useful in evaluating relapsing/advanced forms of medullary thyroid cancer (18F-FDOPA) and selecting patients with advanced follicular and medullary thyroid cancers for theranostic treatments (68Ga/177Ga-somatostatin analogues).","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":"19 4","pages":"317-333"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking the escalation: a comparative analysis of diabetic ketoacidosis severity before and during the COVID-19 pandemic in a Tunisian pioneer study. 揭开升级的面纱：突尼斯先驱研究对 COVID-19 大流行之前和期间糖尿病酮症酸中毒严重程度的比较分析。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1080/17446651.2024.2353723

Asma Gorchane, Taieb Ach, Jihene Sahli, Nassim Bel Hadj Salah, Nadia Ben Lasfar, Asma Ben Abdelkrim, Manel Mallouli, Foued Bellazreg, Wissem Hachfi, Molka Chadli Chaieb, Amel Letaief, Koussay Ach

{"title":"Unmasking the escalation: a comparative analysis of diabetic ketoacidosis severity before and during the COVID-19 pandemic in a Tunisian pioneer study.","authors":"Asma Gorchane, Taieb Ach, Jihene Sahli, Nassim Bel Hadj Salah, Nadia Ben Lasfar, Asma Ben Abdelkrim, Manel Mallouli, Foued Bellazreg, Wissem Hachfi, Molka Chadli Chaieb, Amel Letaief, Koussay Ach","doi":"10.1080/17446651.2024.2353723","DOIUrl":"10.1080/17446651.2024.2353723","url":null,"abstract":"Background: The severity of diabetic ketoacidosis (DKA) at diagnosis increased during the global COVID-19 pandemic. This study aimed to analyze the impact of the pandemic on the clinical and biological severity of DKA in patients with new-onset diabetes mellitus (DM) in Tunisia.Research design and methods: The study included patients hospitalized for new-onset DKA 2 years prior and 2 years during the COVID-19 pandemic. Data was collected retrospectively, and DKA severity was classified based on biological parameters like potential of hydrogen (pH) and HCO3-.Results: The results showed that DKA was more severe during COVID-19, as evidenced by lower potential of hydrogen (pH) (p = 0.006), and serum bicarbonate (HCO3-) levels (p = 0,005). Despite the higher severity of DKA was higher during COVID-19, intensive care unit hospitalizations remained equivalent (p = 0.359). The prevalence of hyponatremia was also higher during COVID-19 (p = 0.024).Conclusion: The findings suggest that delayed diagnosis and COVID-19 May contribute to the increased severity of DKA and electrolyte imbalance during the pandemic. Further research is needed to better understand the underlying mechanisms and develop appropriate strategies to address this issue.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"393-398"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0