E-cadherin as a surrogate marker of epithelial-to-mesenchymal transition for detection of diabetic nephropathy and subclinical atherosclerosis among children and adolescents with type 1 diabete.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2025-04-13 DOI:10.1080/17446651.2025.2492762

Yasmine Ibrahim Elhenawy, Abeer Ahmed Abdelmaksoud, Eman Abdel Rahman Ismail, Zakaria Mostafa Elashmawy, Dina Ebrahem Sallam

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Abstract

Background: Epithelial-to-mesenchymal transition (EMT) may be involved in the pathogenesis of diabetic nephropathy (DN) among adults with type 2 diabetes. The current study aimed to evaluate the role of E-cadherin as a surrogate marker of EMT among children and adolescent with type 1 diabetes (T1D) and DN and its possible relation to carotid intima media thickness (CIMT).

Research design and methods: Sixty participants with T1D were divided equally into two groups based on urinary albumin creatinine ratio (UACR) and compared with 30 healthy controls. Hemoglobin A1c (HbA1c), kidney function tests, serum E-cadherin and CIMT were assessed.

Results: E-cadherin levels were significantly lower in patients with microalbuminuria (56.5 ± 15.8 ng/mL) compared with patients with normoalbuminuria (179.8 ± 45.1 ng/mL) and healthy controls (222.5 ± 39.9 ng/mL) (p < 0.001). E-cadherin correlated negatively with HbA1c (r = -0.42, p = 0.001), UACR (r = -0.89, p < 0.001) and CIMT (r = -0.716, p < 0.001). ROC curve analysis showed that the E-cadherin cutoff value 135 ng/mL could detect nephropathy with 96.67% sensitivity and 86.67% specificity. Logistic regression showed that E-cadherin was a significant independent factor for nephropathy.

Conclusions: E-cadherin is a potential biomarker reflecting EMT activity in both pathogenesis and progression of DN and subclinical atherosclerosis in pediatric patients with T1D.

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e -钙粘蛋白作为1型糖尿病儿童和青少年糖尿病肾病和亚临床动脉粥样硬化检测中上皮-间质转化的替代标志物

背景：上皮-间质转化（EMT）可能参与成人2型糖尿病肾病（DN）的发病机制。本研究旨在评估E-cadherin作为儿童和青少年1型糖尿病（T1D）和DN患者EMT的替代标志物的作用及其与颈动脉内膜中膜厚度（CIMT）的可能关系。研究设计与方法：60例T1D患者根据尿白蛋白肌酐比值（UACR）平均分为两组，并与30例健康对照进行比较。检测血红蛋白A1c （HbA1c）、肾功能、血清e -钙粘蛋白（E-cadherin）和CIMT。结果：微量白蛋白尿患者E-cadherin水平（56.5±15.8 ng/mL）明显低于正常白蛋白尿患者（179.8±45.1 ng/mL）和健康对照组（222.5±39.9 ng/mL）（p r = -0.42, p = 0.001）， UACR （r = -0.89, pr = -0.716, p）。结论：E-cadherin是反映EMT活性在儿科T1D患者DN和亚临床动脉粥样硬化发病和进展中的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.