Gut microbiota alterations and their role in the pathophysiology of obesity following bariatric surgery.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2025-06-03 DOI:10.1080/17446651.2025.2512551

Bas Voermans, Victor Gerdes, Max Nieuwdorp

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引用次数: 0

Abstract

Introduction: Obesity is a global epidemic associated with significant health risks, including type 2 diabetes, cardiovascular diseases, and metabolic disorders. Bariatric surgery remains the gold standard for achieving significant and sustained weight loss. This narrative review was created using literature searches in PubMed, Web of Science, and Scopus.

Areas covered: Bariatric surgery induces shifts in gut microbiota composition, with changes in alpha and beta diversity and alters microbial phyla, such as Bacillota, Bacteroidota, Actinomycetota, Pseudomonadota, and Verrucomicrobiota. Genera and species belonging to these groups that have been associated with the pathophysiology of obesity are reported altered as well. These microbial changes, particularly after Roux-en-Y gastric bypass surgery, are generally linked to cardiometabolic improvements to gut hormone profiles and bile acid metabolism.

Expert opinion: This review focuses on the changes in gut microbiota following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), highlighting longitudinal human studies. Despite conflicting results, some genera, such as Veillonella, Streptococcus, and Akkermansia muciniphila, show consistent increases post-surgery and may serve as markers of metabolic improvements. The predominance of facultative anaerobes suggests a shift in the gut environment post-surgery. These findings are mainly associations and could be further developed into treatment with the use of next-generation probiotics.

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减肥手术后肠道微生物群的改变及其在肥胖病理生理中的作用。

肥胖症是一种与重大健康风险相关的全球性流行病，包括2型糖尿病、心血管疾病和代谢紊乱。减肥手术仍然是实现显著和持续减肥的黄金标准。这篇叙述性综述是使用PubMed、Web of Science和Scopus中的文献搜索创建的。涉及领域：减肥手术引起肠道微生物群组成的变化，改变了α和β的多样性，并改变了微生物门，如杆菌门、拟杆菌门、放线菌门、假单胞菌门和疣菌微生物群。据报道，与肥胖病理生理相关的属和种也发生了改变。这些微生物变化，特别是Roux-en-Y胃旁路手术后，通常与心脏代谢改善、肠道激素谱和胆汁酸代谢有关。专家意见：本综述主要关注Roux-en-Y胃旁路术（RYGB）和袖式胃切除术（SG）后肠道微生物群的变化，重点关注纵向人体研究。尽管结果相互矛盾，但一些属，如细孔菌、链球菌和嗜粘液阿克曼氏菌，在手术后表现出一致的增加，可能作为代谢改善的标志。兼性厌氧菌的优势表明手术后肠道环境发生了变化。这些发现主要是相关的，可以进一步发展到使用下一代益生菌的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.