Experimental Physiology最新文献_第8页

Preemptive iodide treatment in the event of a nuclear disaster: The prepper's guide to the galaxy.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-14 DOI: 10.1113/EP092154

Per Karkov Cramon, Søren Holm, Ronan M G Berg

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The Holy Grail of cardiology?

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-13 DOI: 10.1113/EP092560

Richard Godfrey

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Exercise responses to perceptually regulated high intensity interval exercise with continuous and intermittent hypoxia in inactive overweight individuals.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-12 DOI: 10.1113/EP092338

Jacky Soo, Paul Goods, Olivier Girard, Louise Deldicque, Nathan G Lawler, Timothy J Fairchild

{"title":"Exercise responses to perceptually regulated high intensity interval exercise with continuous and intermittent hypoxia in inactive overweight individuals.","authors":"Jacky Soo, Paul Goods, Olivier Girard, Louise Deldicque, Nathan G Lawler, Timothy J Fairchild","doi":"10.1113/EP092338","DOIUrl":"https://doi.org/10.1113/EP092338","url":null,"abstract":"To investigate the acute effects of hypoxia applied during discrete work and recovery phases of a perceptually regulated, high-intensity interval exercise (HIIE) on external and internal loads in inactive overweight individuals. On separate days, 18 inactive overweight (28.7 ± 3.3 kg m-2; 31 ± 8 years) men and women completed a cycling HIIE protocol (6 × 1 min intervals with 4 min active recovery, maintaining a perceived rating of exertion of 16 and 10 during work and recovery, respectively, on the 6-20 Borg scale) in randomized conditions: normoxia (NN), normobaric hypoxia (inspired O2 fraction ∼0.14) during both work and recovery (HH), hypoxia during recovery (NH) and hypoxia during work only (HN). Markers of external (relative mean power output, MPO) and internal load (blood lactate concentration, heart rate and tissue saturation index (TSI)) were measured. MPO was lower in HH compared to NN, NH and HN (all P < 0.001), with HN also being lower than NN (P < 0.001) and NH (P < 0.023). Heart rate was higher in HN than NN, HH and NH (all P < 0.001). Blood lactate response was higher in NN than HH (P = 0.003) and NH (P = 0.008). Changes in the TSI area above the curve were greater in HN relative to NN, HH and NH (all P < 0.001). Hypoxia applied intermittently during the work or recovery phases may mitigate the declines in mechanical output observed when exercise is performed in continuous hypoxia, although hypoxia implemented during the work phase resulted in elevated heart rate and lactate response. Specifically, exercise performance largely comparable to that in normoxia can be achieved when hypoxia is implemented exclusively during recovery.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole-body passive hyperthermia in healthy humans.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-12 DOI: 10.1113/EP092389

Oliver R Gibson, Orlando Laitano, Kazuhito Watanabe, José González-Alonso

{"title":"Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole-body passive hyperthermia in healthy humans.","authors":"Oliver R Gibson, Orlando Laitano, Kazuhito Watanabe, José González-Alonso","doi":"10.1113/EP092389","DOIUrl":"https://doi.org/10.1113/EP092389","url":null,"abstract":"Hyperthermia can cause intestinal injury, facilitating endotoxin translocation and an inflammatory response that has been associated with heat illness. However, the potential occurrence of these responses has been incompletely reported during passive hyperthermia, and the independent effect of hyperthermia is equivocal. Furthermore, passive hyperthermia is a feature of heat therapy interventions, with mechanistic understanding developing. This experiment quantified the changes in intestinal fatty acid binding protein (iFABP), a marker of intestinal injury, and cytokine, chemokine and growth factor responses during three different prolonged passive hyperthermia protocols. Eight healthy males visited the laboratory on four counterbalanced occasions to undertake 2.5 h of rest (CON), one-leg heating (OLH), two-leg heating (TLH) and whole-body heating (WBH) via a garment circulating water at 50°C. Plasma concentrations of iFABP and 38 cytokines, chemokines and growth factors were quantified periodically, and core temperature (Tcore) was measured continuously. The Tcore increased from baseline in OLH, TLH and WBH (+0.4°C ± 0.2°C, +0.7°C ± 0.2°C and +2.3°C ± 0.4°C, respectively; P < 0.05) but remained unchanged in CON. iFABP increased from baseline in WBH only (∆587 ± 651 pg ml-1) and was different from CON and OLH in WBH after 2 h (P < 0.05). Increased iFABP (∆1085 ± 572 pg ml-1) was observed in 50% of participants at the end of WBH, with the other 50% demonstrating no change (∆89 ± 19 pg ml-1). All chemokines, cytokines and growth factors were unchanged in all protocols. These data indicate that passive whole-body hyperthermia, but not lower-limb hyperthermia, can cause intestinal injury in some individuals without a systemic inflammatory response.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise echocardiography for improved assessment of diastolic filling dynamics.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-09 DOI: 10.1113/EP092177

Mads Fischer, Thomas Bonne, Magnus Bak Klaris, Emil Lenzing, Eric J Stöhr, Jacob Bejder, Carsten Lundby, Nikolai B Nordsborg, Lars Nybo

{"title":"Exercise echocardiography for improved assessment of diastolic filling dynamics.","authors":"Mads Fischer, Thomas Bonne, Magnus Bak Klaris, Emil Lenzing, Eric J Stöhr, Jacob Bejder, Carsten Lundby, Nikolai B Nordsborg, Lars Nybo","doi":"10.1113/EP092177","DOIUrl":"https://doi.org/10.1113/EP092177","url":null,"abstract":"During exercise stress, heart rate (HR) increases to support cardiac output, which also reduces ventricular filling time. Although echocardiography is widely used to assess cardiac function, studies display conflicting data on the dynamic changes in the healthy trained and untrained heart during rest and acute exercise stress. To address these discrepancies, we tested a new echocardiography exercise protocol on two groups with significant differences in cardiorespiratory fitness. Ten untrained individuals with maximal oxygen uptake of 38 ± 8 ml/kg/min and 10 endurance-trained athletes matched for body surface area but with higher maximal oxygen uptake (71 ± 5 ml/kg/min) were evaluated at rest, during semi-recumbent cycling at 25 and 75 W and at a relative workload intensity eliciting a HR of 140 beats/min (HR140). Stroke volume was 36% higher in the trained at rest, and this difference increased during exercise to 42% at 25 W, 46% at 75 W and 63% at HR140 (all P < 0.05). In contrast, no group differences were found in markers of myocardial function (ventricular contraction and relaxation velocities) or other traditional echocardiographic measures of ventricular function at rest or exercise for a given HR. However, while similar at rest, diastolic and systolic function provided limited insight into differences between less fit and highly fit individuals. The new exercise echocardiography protocol improves the ability to uncover differences in dynamic changes in diastolic filling capacity that explain the previously reported higher end-diastolic compliance in endurance-trained athletes.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving blood flow restriction training.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-09 DOI: 10.1113/EP092255

Chansol Hurr

引用次数: 0

The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-07 DOI: 10.1113/EP091737

Rodrigo Fernandez-Gonzalo, Stefan Schneider, Martina Heer, Anna-Maria Liphardt

{"title":"The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.","authors":"Rodrigo Fernandez-Gonzalo, Stefan Schneider, Martina Heer, Anna-Maria Liphardt","doi":"10.1113/EP091737","DOIUrl":"https://doi.org/10.1113/EP091737","url":null,"abstract":"The current understanding of crew health maintenance is founded upon decades of physiological research conducted in terrestrial spaceflight analogues and in low Earth orbit, particularly on the International Space Station. However, as we progress towards the Lunar Gateway and interplanetary missions, it is imperative that the tools employed to maintain crew health are redefined, including the utilisation of exercise countermeasures. The successful implementation of exercise countermeasures for deep space missions must address a number of challenges, including those posed by new environments with elevated levels of cosmic radiation and solar particle events, extended mission durations and constrained space availability. In this Topical Review, the authors address points that are important (and sometimes critical), but often ignored, in order to define future exercise countermeasures for long-duration space missions. Multi-organ countermeasures, countermeasure enjoyment, time-dependent load variability, the relationship between nutrition and the success of exercise countermeasures, and the individual variability in response to a given countermeasure are presented and discussed. The aim of this article is to raise awareness of important aspects that can profoundly influence the efficacy of exercise countermeasures, thereby affecting the health of the crew and the success of the mission during prolonged spaceflight.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mind the gap (again!): On the challenges for women in physiology.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-07 DOI: 10.1113/EP092028

Christina Yfanti

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Nanga Parbat - The mountain of destiny.

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-07 DOI: 10.1113/EP092562

Peter Bärtsch

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Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

IF 2.6 4区医学

Experimental Physiology Pub Date : 2025-02-05 DOI: 10.1113/EP092353

Changhyun Lim, James McKendry, Matthew Lees, Philip J Atherton, Nicholas A Burd, Andrew M Holwerda, Luc J C van Loon, Chris McGlory, Cameron J Mitchell, Kenneth Smith, Daniel J Wilkinson, Tanner Stokes, Stuart M Phillips

{"title":"Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?","authors":"Changhyun Lim, James McKendry, Matthew Lees, Philip J Atherton, Nicholas A Burd, Andrew M Holwerda, Luc J C van Loon, Chris McGlory, Cameron J Mitchell, Kenneth Smith, Daniel J Wilkinson, Tanner Stokes, Stuart M Phillips","doi":"10.1113/EP092353","DOIUrl":"https://doi.org/10.1113/EP092353","url":null,"abstract":"Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by increased loading, ageing and unloading (disuse), all of which are subject to modification by nutrition and other environmental stimuli. The understanding of muscle proteome remodelling has undergone a renaissance recently with the reintroduction of deuterated water (D2O) and its ingestion to label amino acids and measure their incorporation into proteins. However, there is confusion around the use of the deuterated water methodology and the interpretation of the data it provides. Here, we provide a short review of some of the more salient features of the method and clarify some of the confusion around the method of deuterated water methods and its use in humans and how the interpretation of the data is in contrast to that of rodents.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0