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THE ROLE OF INFLAMMATION IN AGE-RELATED DISEASES 炎症在年龄相关疾病中的作用
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.381
M. Jgarkava, R. Rukhadze, N. Karanadze, I. Pantsulaia
{"title":"THE ROLE OF INFLAMMATION IN AGE-RELATED DISEASES","authors":"M. Jgarkava, R. Rukhadze, N. Karanadze, I. Pantsulaia","doi":"10.52340/JECMJ.2021.381","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.381","url":null,"abstract":"The risk of developing of the diseases such as Alzheimer's disease, atherosclerosis, osteoporosis, arthritis, type 2 diabetes and cancer increases with age. This is why these diseases are also referred to as age-related diseases. There is evidence that the development of age-related diseases significantly contributes to the so-called. Immune aging, in particular, age-related changes in the immune system, one of the manifestations of which is a low level systemic chronic inflammation. The term \"inflammatory aging\" (Inflamm-aging) well describes the close relationship between low-grade chronic inflammation and aging. At the present stage of the development of medicine, the mechanisms associated with the development of age-related, low-level, chronic inflammatory processes and the ways of their evaluation require further in-depth, multidisciplinary studies. Clearly, inflammatory aging is a predictor of many age-related disease development and high risk of death. Clinical studies have confirmed the view that inhibition of certain mediators of inflammation may reduce the incidence of age-related diseases. However, similar studies focusing on anti-inflammatory drugs are few in number and the results are ambiguous. Further fundamental and translational studies in this direction hope that in the future we will be able to regulate inflammatory processes in a way that ensures a healthy and long-lasting aging of the population.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89412776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHARMACEUTICAL CARE IN TIMES OF COVID-19 PANDEMIC COVID-19大流行时期的药学服务
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.379
N. Nemsitsveridze, T. Tchumburidze, E. Pruidze, N. Nikuradze, T. Zarkua, M. Gelashvili
{"title":"PHARMACEUTICAL CARE IN TIMES OF COVID-19 PANDEMIC","authors":"N. Nemsitsveridze, T. Tchumburidze, E. Pruidze, N. Nikuradze, T. Zarkua, M. Gelashvili","doi":"10.52340/JECMJ.2021.379","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.379","url":null,"abstract":"The article discusses the peculiarities of pharmaceutical care in relation to the Covid-19 pandemic. A pharmaceutical care algorithm was developed and tested on people who displayed cold symptoms during the pandemic. 50 patients (with flu and cold symptoms) who visited the pharmacy were interviewed using the Pharmaceutical Care Algorithm. The results showed that 41 patients only had mild symptoms, while 9 out of 50 had probable symptoms of Covid 19. Patients were referred to the physicians for further examination. An appropriate pharmaceutical care plan was developed. The Covid-19 pandemic has further showcased a function of the pharmacist as a provider of appropriate care in a pharmacy facility. It showed us that a pharmacist has a vital role in preventing the pandemic, both by properly informing patients and by implementing an appropriate pharmaceutical care plan. In view of all the above, it is now vital to maintain an already developed algorithm and further update it based on how the pandemic progresses.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75216117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ERYTHEMA NODOSUM: CLINICAL CASE 结节性红斑1例
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.380
Tinatin Kutubidze, M. Kherkheulidze, M. Kobakhidze, Irine Kekelidze, Marina Chiqovani
{"title":"ERYTHEMA NODOSUM: CLINICAL CASE","authors":"Tinatin Kutubidze, M. Kherkheulidze, M. Kobakhidze, Irine Kekelidze, Marina Chiqovani","doi":"10.52340/JECMJ.2021.380","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.380","url":null,"abstract":"Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins. Common triggers for EN include infection, drugs, pregnancy, malignancy, and inflammatory conditions, such as sarcoidosis or gastrointestinal diseases; however, many cases are idiopathic. We present clinical case of 12 y.o girl with EN associated with EBV.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79508665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOREIGN BODY IN THE DIGESTIVE TRACT (ESOPHAGUS) CASE STUDY 消化道(食道)异物个案研究
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.386
N. Sanodze, Nano Shvangiradze
{"title":"FOREIGN BODY IN THE DIGESTIVE TRACT (ESOPHAGUS) CASE STUDY","authors":"N. Sanodze, Nano Shvangiradze","doi":"10.52340/JECMJ.2021.386","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.386","url":null,"abstract":"The majority of foreign body ingestions occur in children between the ages of six months and three years. Most cases are brought to medical attention by a child's caregivers following a witnessed or reported ingestion. Many of the children are asymptomatic or have transient symptoms at the time of the ingestion. Clinical management focuses on identifying and treating the cases at risk for complications, which depend on the location and type of foreign body. A battery lodged in the esophagus should be removed urgently. There was not recommended to take anything orally when swallowing a battery according to these guidelines until the body has been radiographically determined and removed endoscopically. Recent studies using natural and artificial models of batteries in the esophagus of animals have shown that early and repeated administration of honey or sucralfate before removal may reduce the degree of esophageal burns.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78703287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PROBLEMATIC ISSUES IN THE ETIOLOGY AND PATHOGENESIS OF ADENOMYOSIS b子宫腺肌症的病因和发病机制有待解决的问题
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECM.2021.391
B. Metreveli, D. Gagua, G. Burkadze
{"title":"PROBLEMATIC ISSUES IN THE ETIOLOGY AND PATHOGENESIS OF ADENOMYOSIS","authors":"B. Metreveli, D. Gagua, G. Burkadze","doi":"10.52340/JECM.2021.391","DOIUrl":"https://doi.org/10.52340/JECM.2021.391","url":null,"abstract":"Nowadays, adenomyosis represents one of the most common pathology of female genital system. It occurs at different ages, including nulliparous, infertile and multiparous women. The etiology of adenomyosis is still under investigation. Despite the fact that there are many different theories, none of them fully explain the mechanisms of adenomyoisis development. The pathogeneis of adenomyosis is also less studied. Many studies indicate the involvement of female sex hormone receptors, cell proliferation and apoptosis, as well as the involvement of inflammation. Some investigators describe the malignant transformation of adenomyosis, which makes the study of the disease etiology and pathogenesis more important. In current review, we discuss the different theories of adenomyosis development, as well as the risk of malignant transformation.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82470611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STUDY OF THE ORAL CAVITY CONDITION OF THE SOCIALLY VULNERABLE POPULATION OF BATUMI, AUTONOMOUS REPUBLIC OF ADJARA 阿贾拉自治共和国巴统社会弱势人口口腔状况研究
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.385
S. Davitadze, Qetevan Franchuk, N. Chomakhashvili, Z. Chomakhashvili, M. Phutkaradze, N. Zosidze, O. Tsetskhladze, Ruslan Bolkvadze, Demur Jincharadze
{"title":"STUDY OF THE ORAL CAVITY CONDITION OF THE SOCIALLY VULNERABLE POPULATION OF BATUMI, AUTONOMOUS REPUBLIC OF ADJARA","authors":"S. Davitadze, Qetevan Franchuk, N. Chomakhashvili, Z. Chomakhashvili, M. Phutkaradze, N. Zosidze, O. Tsetskhladze, Ruslan Bolkvadze, Demur Jincharadze","doi":"10.52340/JECMJ.2021.385","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.385","url":null,"abstract":"Based on the results of the research, the most important conclusion is that due to the high cost of dental care (especially due to the high cost of dental materials), most of the socially vulnerable people do not receive such care today. We consider it possible for the Social Department of the Ministry of Health as well as the Social Assistance Departments of the cities to increase the budget funds to solve this problem.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74594963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EPISODES OF HEARTBURN AND BLOATING IN MEDICAL PRACTICE 医疗实践中胃灼热和腹胀的发作
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.390
Vazha Gvantseladze, Nana Gnantseladze
{"title":"EPISODES OF HEARTBURN AND BLOATING IN MEDICAL PRACTICE","authors":"Vazha Gvantseladze, Nana Gnantseladze","doi":"10.52340/JECMJ.2021.390","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.390","url":null,"abstract":"The aim of the study was to study the frequency and nature of episodes of heartburn and bloating in patients with duodenal and gastric ulcers in the Georgian population, considering the histomorphological and morphometric changes of the gastric mucosa and the parameters of gastric secretion. At the same time, we were interested in analyzing patients' anamnesis before being hospitalized for the last 2 months. The analysis of the material showed that incidence of heartburn episodes in the Georgian population is clearly higher in patients with peptic ulcer disease 12 - (79.9%) than in patients with gastric ulcer (9 - 31.9%). Episodes of heartburn in these patients are characterized not only by increasing of rate (more than 50 episodes), both day and night, but the intensity and duration (which is due to abnormal gastroesophageal reflux). This is a high risk for the occurrence of heartburn episodes. As for bloating, it was detected in patients with duodenal ulcer (11–26.2%), in gastric ulcer 11– (32.9%). The main pathogenetic aspects of heartburn episodes were found to be diffuse fundal glands hyperplasia and high acidity (duodenal ulcer and pyloric anterior ulcer). It was also found that a large percentage of patients were not treated properly, leading to impaired ability to work and changes in quality of life and disease progression.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85777638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OBSERVATION OF MORPHOLOGICAL CHANGES IN THE FETUS AND PLACENTA OF PREGNANT WOMEN INFECTED WITH CYTOMEGALOVIRUS THROUGH ULTRASOUND EXAMINATION 巨细胞病毒感染孕妇胎儿及胎盘形态变化的超声观察
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.387
T. Lomsianidze
{"title":"OBSERVATION OF MORPHOLOGICAL CHANGES IN THE FETUS AND PLACENTA OF PREGNANT WOMEN INFECTED WITH CYTOMEGALOVIRUS THROUGH ULTRASOUND EXAMINATION","authors":"T. Lomsianidze","doi":"10.52340/JECMJ.2021.387","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.387","url":null,"abstract":"In 2008-2018, 89 pregnant women registered at the Beaumonde Clinic were observed with only cytomegalovirus activity. Laboratory tests for cytomegalovirus were performed 4 times in total, and ultrasound examination was performed 3 times during pregnancy. The results were distributed as follows: (1) We could have assumed with high probability that we had reinfection processes and not a primary infection. (2) During the ultrasound examinations, no significant organic disturbances in the development of the fetus were detected. (3) In all cases, various morphological changes were observed in the placenta, which are not specific for CMV and are found during any infectious process: premature aging of the placenta, increase in thickness and enhanced calcification. Degenerative changes in placental tissues increase the risk of perinatal loss. (4) As a result of childbirth, all newborns were born without visible pathology. However, this did not rule out latent disease and later detected pathologies.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84663640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMMUNOMODULATORY AND CLINICAL EFFECTIVITY OF THE DRUG "LAZOLEX" IN TREATMENT OF RECURRENT APHTHOUS STOMATITIS (RAS) 唑来来治疗复发性口腔炎的免疫调节作用及临床疗效观察
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECM.2021.375
M. Gogotishvili, N. Abashidze, Nino Korsantia, Nato Korsantia
{"title":"IMMUNOMODULATORY AND CLINICAL EFFECTIVITY OF THE DRUG \"LAZOLEX\" IN TREATMENT OF RECURRENT APHTHOUS STOMATITIS (RAS)","authors":"M. Gogotishvili, N. Abashidze, Nino Korsantia, Nato Korsantia","doi":"10.52340/JECM.2021.375","DOIUrl":"https://doi.org/10.52340/JECM.2021.375","url":null,"abstract":"The purpose of this study was to study the immunomodulatory and clinical properties of the Georgian drug “LAZOLEX” in patients with Recurrent Aphthous Stomatitis (RAS). Clinical and Immunological parameters were studied in 50 patients, the results showed the correlation between the condition of immune system and the severity of the RAS, i.e., the most severe immunosuppression was recorded in patients with severe stomatitis. 5% Gel of “LAZOLEX” compared to traditional therapy, showed the same high clinical activity, but the presence of immunocorrective properties in LAZOLEX manifested itself in an improvement in the quality of patient treatment: decrease of time of epithelization and a significant increase in the duration of remission. Conducted clinical, laboratory and immunological studies allow us to recommend LAZOLEX for active use in dental practice for RAS.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88077813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
MULTIPLE INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) ASSOCIATED WITH COVID-19 与COVID-19相关的儿童多发性炎症综合征(misc
EXPERIMENTAL & CLINICAL MEDICINE GEORGIA Pub Date : 2021-07-07 DOI: 10.52340/JECMJ.2021.378
Tinatin Kutubidze, Maia Kherkheulidze, M. Kobakhidze, Irine Kekelidze, E. Nakhutsrishvili
{"title":"MULTIPLE INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) ASSOCIATED WITH COVID-19","authors":"Tinatin Kutubidze, Maia Kherkheulidze, M. Kobakhidze, Irine Kekelidze, E. Nakhutsrishvili","doi":"10.52340/JECMJ.2021.378","DOIUrl":"https://doi.org/10.52340/JECMJ.2021.378","url":null,"abstract":"There is a difference between MIS-C and KD. This is probably a postinfectious inflammatory response manifested with elevation of inflammatory markers and signs of myocardial damage. So, MIS-C could be an analogue of late phase COVID-19, which we are seeing in adult patients. This phase is also characterized by “cytokine storm” and can include severe myocardial disfunction, renal damage and laboratory changes consistent with MAS. Despite growing numbers of children with MIS-C, it still remains as rare condition and has good outcome in majority of cases. Children with MIS-C need special care of rheumatologist, infectious disease and intensive disease specialist collaboration.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75862115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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