EXPERIMENTAL & CLINICAL MEDICINE GEORGIA最新文献

{"title":"DEPRESSION AND CANCER","authors":"S. Vashadze, M. Artmeladze","doi":"10.52340/jecm.2021.613","DOIUrl":"https://doi.org/10.52340/jecm.2021.613","url":null,"abstract":"The study included 100 patients from 25 to 75 years. Out of them women were 60, Men- 40, surgery had only 45 patients, chemotherapy 16. 4 After radiation therapy, combined therapy - 35 patients. 6 were Suffering from lung cancer, 22 -breast cancer, skin cancer -6, 7 -gastric cancer, prostate and bladder cancer -4 patients , 15- ovarian cancer . The uteruscancer-25, from 100 patients 20% was suffering from mild depression , The average - 44%., Severe - 35%. without depression -1%. Suicidal taught was detected in 45% of surveyed patients, a panic or somatic -vegetatic disorders -79% (headache, dizziness, palpitations, and weakness). A large part of the patients, 80% complained of sleep disturbance (difficulty in sleeping, in the middle of the night awakening, early awakening), some of the symptoms of asthenia was found in 56%. psychological rehabilitation centers for cancer patients is necessary to establish on a base of oncology clinics. Professional psychological help will improve oncology patients 'quality of life'.Cancer patients diagnosed with major depression may benefit from a combined modality approach that includes both psychosocial and pharmacologic interventions. Psychosocial treatment approaches that may be of value include those that provide information and support and those that address any combination of emotional, cognitive, and behavioral factors.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72976174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEMENTIA IN ONCOLOGICAL PATIENTS","authors":"Sophio Brunjadze, S. Vashadze, K. Dolidze, M. Artmeladze","doi":"10.52340/jecm.2021.611","DOIUrl":"https://doi.org/10.52340/jecm.2021.611","url":null,"abstract":"Oncological diseases are one of the main causes of morbidity and mortality in the world. The problem is quite topical since the number of patients with cancer is a sensitive theme. At present, there are about 20 million people having the disease all over the world. Hence, the number of elderly people with the disease is about 10-15%. The purpose of our research was to study dementia in cancer patients. The study was conducted in the Batumi high-tech hospital (Batumi Oncological Center). 100 patients aged 25 to 75 participated in this study. Among them, the 60 patients were female and 40 were male. At the same time, only 45 patients were operated on. Of these, 16 patients were operated after chemotherapy, 4 patients after radiotherapy and 35 patients during combination therapy. 6 patients with lung cancer, 22 patients with breast cancer, 6 patients with skin cancer, 7 patients with gastric cancer, 4 patients with bladder cancer, 15 patients with ovarian cancer, 25 patients with uterine cancer were examined. In the study, three of them had the family history of dementia. We studied the patient's medical history, physiological data, assessed their mental and cognitive functions to determine the diagnosis of dementia. We studied the patient's medical history, physiological data, assessed their mental and cognitive functions, mini-mental state examination, and carried out a survey of family members as the patients often had difficulty precisely describing the symptoms to determine the diagnosis of dementia. Out of 100 patients, 20% of them had mild dementia, 44% - moderate dementia and 35 % - severe dementia. Among the patients examined, dementia was not observed in 1%. Computed tomography of the brain was performed on the examined patients. Cerebral atrophy, a decrease in brain mass and volume in 34%, cortical atrophy in 60% of patients and the expansion of the ventricle system of the brain in 35% were revealed in the pathomorphological picture. The atrophic process is strongly expressed in the pariental (17%), frontal and temporal lobes (76%). Therefore, dementia is quite common in cancer patients with severe and moderate depression, predominant in 79%. Dementia was not observed only in one case, which is very important. The researchers point out reversible dementia after chemotherapy, which is reversible after a while. Community involvement has great importance for the treatment and psychological adaptation to the new reality of cancer patients. It is necessary to develop educational programs aimed at providing assistance from the moment of diagnosis to the end of treatment.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85985320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECOTOXICOLOGY OF PESTICIDES USED AGAINST HALYOMORPHA HALYS AND STUDY OF THEIR POSSIBLE HARMFUL EFFECTS ON THE POPULATION OF GURIA REGION","authors":"Marina Giorgobiani, Nana Chkhaidze, Zurab Chekurashvili, George Iakobashvili, N. Meskhi, B. Zurashvili","doi":"10.52340/jecm.2021.567","DOIUrl":"https://doi.org/10.52340/jecm.2021.567","url":null,"abstract":"Bifenthrin (from Pyrethroid chemical compound group) containing pesticides are used to fight Brown marmorated stink bug (Halyomorpha Halys) in Georgia. In order to study possible impact of these substances on the human health condition, descriptive epidemiological survey was made among inhabitants of the pesticides action area. The survey polled 96 inhabitants. After survey results analysis, it was detected, that in many cases, respondents who had contact with above mentioned pesticides suffered from various complaints, which were provoked by these pesticides. People who had complaints have following diagnoses: hypertonic, sciatica, kidney diseases, goiter, allergy, varicose veins, neurosis, bronchitis and other. While, they complained on the following: burning eyes, skin burning, more cough, itchy eyes, nausea, relax, dizziness and other. It should be took into consideration, that because of the negligence, one of the respondents had light poisoning from the pesticides. Unfortunately, sometimes chemical treatment is held without prior notice.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83077333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTIVENESS OF LEARNING CARDIAC ARRHYTHMIAS IN CLINICAL SKILLS DEPARTMENT","authors":"I. Manjavidze, P. Nozadze, D. Chitaishvili","doi":"10.52340/jecm.2021.594","DOIUrl":"https://doi.org/10.52340/jecm.2021.594","url":null,"abstract":"Early and proper diagnosis of arrhythmias is important. However, there is a limited knowledge and skills in identifying and caring for patients with life-threatening arrhythmias among medical students. The aim of this study was to compare 6th year MD program students' pre-post-training knowledge and the ability to detect life-threatening arrhythmias. 140 6th year MD program students took part in this study. Evaluations were performed before and after training in cardiac arrhythmias. Results: The majority of the participants received a high level of knowledge in identifying life-threatening arrhythmias on the ECG strip. Modern teaching methods improve the learning achievements among students.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83014719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE DIAGNOSTIC POTENTIAL OF URINAY AND SERUM CYTOKERATINS FOR URINARY BLADDER CANCER","authors":"G. Adeishvili, M. Shavdia, D. Tabagari","doi":"10.52340/jecm.2021.562","DOIUrl":"https://doi.org/10.52340/jecm.2021.562","url":null,"abstract":"In our opinion, the obtained results show that the level of UBC cytokeratin determined in urine reflects the destruction of tissue by the tumor to a greater extent with deep invasion and with large tumor sizes. We believe that a decrease in the sensitivity of the UBC test in detecting recurrence in patients after TUR, in comparison with the sensitivity of the UBC test in patients with BC prior to treatment, is associated with an initial level of cytodestruction in the relapse of BC. The level of serum cytokeratin TPA largely reflects the onset of metabolic changes in the tumor focus. It is the combination of UBC + TPA tests that gives rise to true-positive results and a reduction in false-negative results, which increases the sensitivity of the method.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85368112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF QUALITY OF LIFE OF HEMODIALYSIS PATIENTS BY MWQOLI METHOD","authors":"A. Shamanadze, T. Kandashvili, I. Tchokhonelidze","doi":"10.52340/jecm.2021.561","DOIUrl":"https://doi.org/10.52340/jecm.2021.561","url":null,"abstract":"Chronic Kidney Disease (CKD) is the global problem. This disease has negative effect on patients' quality of life. Worldwide the Missoula-VITAS Quality of Life Index scale (MVQOLI) is used for examinations of the quality of life (QoL). The aim of this study was to examine QoL in hemodialysis patients using the Missoula-VITAS Quality of Life Index-15 (MVQOLI-15) in one dialysis center in Tbilisi, Georgia. The sample study consisted of 272 patients (12 female, 160 male; age 18-80) undergoing hemodialysis. Data were collected by MVQOLI. The total MVQOLI-15 score in our study was 16.43, which is slightly above the middle of the index scale. The majority of HD patients rate their QoL as “Fair”. Interpersonal relationships, well-being, and transcendental experiences are factors that have a greater impact on the quality of life of hemodialysis patients than other factors. The study should be expanded and conducted not only in hemodialysis patients but also in CKD and ESRD patients in order to provide adequate intervention as soon as their quality of life deteriorates.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"425 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77132965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DYNAMICS OF ACCUMULATION OF ALKALOIDS SUM IN TWO SPECIESS DELPHINIUM L. GROWING IN GEORGIA","authors":"L. Kintsurashvili, T. Suladze","doi":"10.52340/jecm.2021.551","DOIUrl":"https://doi.org/10.52340/jecm.2021.551","url":null,"abstract":"The research objects were underground and over ground parts of Delphinium speciosum Bieb and Delphinium flexuosum Bieb., which were collected in the Tsikisjvari, Georgia in different vegetation phases. According to the results of the study pharmacological active methyllycaconitine and lycoctonine are dominant basics of the total alkaloids in the underground and overground parts of Delphinium speciosum and Delphinium flexuosum, growing in Georgia.Based on the research it was suggested that the most reasonable period for collection is flowering phase for the overground parts and fructification phase for the underground parts of the above-mentioned species of Delphinium speciosum Bieb. and Delphinium flexuosum Bieb.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82819587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE VITAMIN D AND AUTOIMMUNE THYROIDITIS IN PEDIATRIC AGE","authors":"N. Tchelidze, S. Glonti, D. Baratashvili, N. Kedelidze, I. Nakashidze","doi":"10.52340/jecm.2021.553","DOIUrl":"https://doi.org/10.52340/jecm.2021.553","url":null,"abstract":"Autoimmune diseases of the thyroid gland, including autoimmune thyroiditis, are widespread diseases. Autoimmune thyroiditis (AT) is found within the pediatric age. The aim is to study vitamin D within pediatric age patients with autoimmune thyroi­ditis. The study showed that the vitamin D level is low within AT compared to the control group (p=0.017).","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79274558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOLECULAR CHARACTERISTICS AND PROGNOSTIC MARKERS IN ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA (CRITICAL REVIEW)","authors":"Tamar Goduadze, G. Tevdorashvili, G. Burkadze","doi":"10.52340/jecm.2021.549","DOIUrl":"https://doi.org/10.52340/jecm.2021.549","url":null,"abstract":"Endometrial carcinoma represents the most common gynaecologic malignancy, which frequently arises from malignant progression of endometrial intraepithelial neoplasia (EIN). Nowadays, there are no defined prognostic markers for the prognosis of the malignant progression of EIN and it still represents the subject of various investigations. Different studies indicate, that sex hormone receptors, DNA damage and apoptosis proteins, as well as epithelial-mesenchymal transformation markers play an important role in the progression of EIN. However, most of the published studies are full of contradictory results, which indicates that additional studies are necessary. In current review, we will discuss the current knowledge about the mentioned markers in terms of the prognosis of EIN.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75424693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VITAMIN D AND THYROID HORMONES IN PATIENTS WITH BREAST BENIGN TUMOR","authors":"S. Glonti, R. Vadachkoria, Jumber Ungiadze","doi":"10.52340/jecm.2021.555","DOIUrl":"https://doi.org/10.52340/jecm.2021.555","url":null,"abstract":"The Breast Benign tumor (BBT) is currently considered a significant breast health problem within women of all ages. In the present study, we aimed to investigate the Tumor markers CA125 and CA153, thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and vitamin D within benign breast tumor (BBT) during the reproduction ages. Twenty patients (ten patients in the control group and ten patients in cases (Breast Benign Tumor); Notably, the studies confirm the decrease in FT4 and FT3 and increase of the thyroid-stimulating hormone (TSH). In addition, the decreased level of Vitamin D is also revealed in BBT.","PeriodicalId":12081,"journal":{"name":"EXPERIMENTAL & CLINICAL MEDICINE GEORGIA","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90631148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}