THE DIAGNOSTIC POTENTIAL OF URINAY AND SERUM CYTOKERATINS FOR URINARY BLADDER CANCER

Abstract

In our opinion, the obtained results show that the level of UBC cytokeratin determined in urine reflects the destruction of tissue by the tumor to a greater extent with deep invasion and with large tumor sizes. We believe that a decrease in the sensitivity of the UBC test in detecting recurrence in patients after TUR, in comparison with the sensitivity of the UBC test in patients with BC prior to treatment, is associated with an initial level of cytodestruction in the relapse of BC. The level of serum cytokeratin TPA largely reflects the onset of metabolic changes in the tumor focus. It is the combination of UBC + TPA tests that gives rise to true-positive results and a reduction in false-negative results, which increases the sensitivity of the method.