European Journal of Radiology最新文献

{"title":"Robustness of radiomic features in photon-counting CT: Impact of radiation dose and virtual monoenergetic reconstructions compared to dual-energy CT","authors":"Haijia Mao ,&nbsp;Tianhao Feng ,&nbsp;Sangying Lv ,&nbsp;Dingbo Shu ,&nbsp;Fandong Zhu ,&nbsp;Jianfeng Yang ,&nbsp;Zhenhua Zhao","doi":"10.1016/j.ejrad.2025.112257","DOIUrl":"10.1016/j.ejrad.2025.112257","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of Virtual Monoenergetic Image (VMI) reconstructions and radiation dose on radiomic feature reproducibility in photon-counting CT (PCCT) and compare its performance with dual-energy CT (DE-CT).</div></div><div><h3>Methods</h3><div>An anthropomorphic abdominal phantom (Kyoto Kagaku CTU-41) simulating liver, kidney, and vertebral tissues was scanned on a PCCT system at four dose levels (1, 3, 6, 12 mGy) with VMI reconstructions (40–100 keV). DE-CT acquisitions (80/140 kVp) at matched doses served as the comparator. Radiomic features were extracted from standardized ROIs using PyRadiomics. Reproducibility was quantified via intraclass correlation coefficient (ICC), concordance correlation coefficient (CCC), and coefficient of variation (CV &lt; 10 %).</div></div><div><h3>Results</h3><div>Demonstrated exceptional reproducibility across all doses (ICC/CCC &gt; 0.96) for liver, with peak stability at 6 mGy (ICC = 0.992, CCC = 0.998) and 44.75 % of features achieving CV ≤ 10 %. Kidneys exhibited inverse dose-reproducibility relationships, with optimal stability at 1 mGy (ICC = 0.783, CCC = 0.858). Vertebrae achieved superior reproducibility at 12 mGy (ICC = 0.631, CCC = 0.859), while 1 mGy and 3 mGy showed lower agreement (ICC &lt; 0.60) due to partial volume effects.<!--> <!-->Liver radiomics showed superior reproducibility at 70–80 keV (ICC/CCC ≈1.00) and low variability (CV＞20 %: 35.24–38.10 %). For Kidneys, high consistency was achieved at 70–80 keV (ICC＞0.993, CCC＞0.997) and persistent variability (CV＞20 %: 52.38–68.57 %).</div></div><div><h3>Conclusion</h3><div>PCCT enables robust radiomics for homogeneous tissues (liver) across all doses, while heterogeneous regions (kidney, vertebrae) require energy- and dose-optimized protocols. The inverse dose-reproducibility relationship in renal radiomics highlights PCCT’s unique spectral advantages for low-dose imaging. These findings advocate for clinical adoption of PCCT with protocol standardization to unlock reliable, dose-efficient radiomic biomarkers.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112257"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in microvessel density in normal-appearing white matter in relation to cerebral small vessel disease: A cohort study","authors":"Johannes H. Reilly ,&nbsp;Isabelle van Sloten ,&nbsp;Ahmed A. Khalil ,&nbsp;Uchralt Temuulen ,&nbsp;Elias Kellner ,&nbsp;Huma Fatima Ali ,&nbsp;Jochen B. Fiebach ,&nbsp;Ivana Galinovic","doi":"10.1016/j.ejrad.2025.112250","DOIUrl":"10.1016/j.ejrad.2025.112250","url":null,"abstract":"<div><h3>Background and purpose</h3><div>White matter hyperintensities (WMH) of presumed vascular origin describe structural alterations of cerebral white matter, thought to result from cerebral small vessel disease. However, the in vivo effects of WMH on normal-appearing white matter microvasculature remain elusive. Therefore, we conducted an exploratory investigation of microvascular density in normal-appearing and pathological white matter in patients with WMH.</div></div><div><h3>Methods</h3><div>Using magnetic resonance imaging-based vessel size imaging we investigated an index of microvessel density in vivo in two clinical cohorts with ischaemic events (cohort_A, <em>N</em> = 88, mean age = 77.18) and intracranial neoplasms (cohort_B, <em>N</em> = 58, mean age = 65.45). For analysis, regions of interest were created for the whole normal-appearing white matter, the normal-appearing centrum semiovale, the WMH, the WMH penumbra, and the normal-appearing striatum. The severity of WMH-burden was quantified using the Wahlund score.</div></div><div><h3>Results</h3><div>In both cohorts, the index of microvessel density in the striatum was significantly higher than in normal-appearing white matter. There was no significant difference between WMH and WMH penumbra. However, both WMH and WMH penumbra had a significantly lower index of microvessel density than normal-appearing white matter in the subgroup of patients with high Wahlund scores. Lastly, the index of microvessel density in the normal-appearing centrum semiovale was higher in patients with high compared to low Wahlund scores in both cohorts. This comparison was not significant after adjusting for age.</div></div><div><h3>Conclusions</h3><div>Our results suggest a complex relationship between cerebral small vessel disease-related WMH and microvascular changes in the normal-appearing white matter, potentially indicative of WMH-related angiogenesis.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112250"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human factors in diagnostic radiology: practical challenges and cognitive biases","authors":"Jake E. Cowen ,&nbsp;Ganesh Vigneswaran ,&nbsp;Jasper Bekker ,&nbsp;Peter A. Brennan ,&nbsp;Rachel S. Oeppen","doi":"10.1016/j.ejrad.2025.112248","DOIUrl":"10.1016/j.ejrad.2025.112248","url":null,"abstract":"<div><div>Diagnostic radiology is an essential and increasingly in-demand medical specialty, providing timely reports that inform clinical decision-making. However, human factors, including environmental distractions and cognitive biases, can significantly influence the accuracy of imaging interpretation. This review explores these challenges in two parts: (1) practical human factor issues such as distractions, interruptions, and fatigue, and (2) cognitive biases that impact diagnostic accuracy. Evidence-based mitigation strategies, including environmental optimisation, structured reporting, and cognitive debiasing techniques, are also discussed. Addressing these issues is crucial for minimising diagnostic error and improving patient outcomes.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112248"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable combined models for predicting treatment response and hematologic toxicity in locally advanced gastric cancer treated with PD-1 blockade and neoadjuvant chemotherapy","authors":"Yuze Wei ,&nbsp;Yanmei Zhu ,&nbsp;Qian Dong ,&nbsp;Wentao Wang ,&nbsp;Tao Yu ,&nbsp;Jianjun Zhang ,&nbsp;Yue Dong","doi":"10.1016/j.ejrad.2025.112256","DOIUrl":"10.1016/j.ejrad.2025.112256","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to establish and validate the interpretable combined models for treatment response (TR) and hematologic toxicity (HT) after programmed cell death protein 1 blockade plus neoadjuvant chemotherapy in locally advanced gastric cancer (LAGC).</div></div><div><h3>Methods</h3><div>195 patients with LAGC were enrolled from two centres (117, 50 and 28 patients in the training, internal validation and external validation cohorts). The changes of radiomics features from pre-treatment and post-treatment gastric computed tomography images were extracted to build delta radiomics score and predict TR, as well as another radiomics score from pre-treatment vertebral computed tomography images for the prediction of HT, and both combined models were established from clinicopathological characteristics and radiomics score. The predictive performance of the combined models were evaluated using receiver operating characteristics, calibration and decision curve analyses. Interpretability was assessed using the shapley additive explanations framework (SHAP).</div></div><div><h3>Results</h3><div>The area under curve (AUC) in the combined model for predicting TR were 0.893,0.846 and 0.913 for the training, internal validation and external validation cohorts, respectively. The AUC in the combined model for predicting HT were 0.871, 0.917 and 0.865 for the training, internal validation and external validation cohorts, respectively. SHAP summary plots show the importance of each feature on the prediction outcome, while waterfall and force plots depict individual features’ contributions to a response variable.</div></div><div><h3>Conclusions</h3><div>The combined models based on radiomics features for predicting TR and HT after programmed cell death protein 1 blockade plus neoadjuvant chemotherapy in LAGC demonstrated good predictive performance.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112256"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Earlier discharge from follow-up for lung cancer screening using artificial intelligence in computed tomography","authors":"I.A. Gimbel ,&nbsp;M. Bergsma ,&nbsp;M.A.J. van de Weijer ,&nbsp;A. Welling ,&nbsp;A. Olijve ,&nbsp;P.R. Algra","doi":"10.1016/j.ejrad.2025.112253","DOIUrl":"10.1016/j.ejrad.2025.112253","url":null,"abstract":"<div><h3>Background</h3><div>Lung cancer is the leading cause of cancer death worldwide. Effective screening and early detection are critical in reducing mortality. Artificial intelligence (AI) methods have been proved useful in the diagnosis of pulmonary nodules and early diagnosis of lung cancer. However, the implementation of lung cancer screening and frequent detection of incidental pulmonary nodules lead to more computed tomography scans resulting in increased costs. Therefore, determining the cost-effectiveness of AI is important for implementing these methods in routine clinical practice. Based on volume measurements of pulmonary nodules performed by AI, patients could potentially be discharged earlier from incidental lung nodule follow-up.</div></div><div><h3>Objective</h3><div>To determine whether using AI volume measurements of pulmonary nodules on CT scan results in shorter follow-up time of incidental lung nodule follow-up.</div></div><div><h3>Methods</h3><div>For this retrospective cohort study patients with follow-up chest computed tomography for incidental pulmonary nodules were included. The primary outcome was the proportion of patients that could have been discharged earlier from follow-up based on the current BTS guidelines using AI volume measurements.</div></div><div><h3>Results</h3><div>A total of 252 patients were included, of which 49 (19,4 %; 95 % confidence interval [CI], 14.7–24.9) patients could have been earlier discharged from follow-up using AI volume measurements.</div></div><div><h3>Conclusion</h3><div>Based on current BTS guidelines using AI volume measurements of pulmonary nodules leads to shorter follow-up time period for incidental lung nodule follow-up and therefore a reduction of unnecessary computed tomography imaging, appointments and cost reduction.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112253"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast-field-echo resembling a CT using restricted echo-spacing (FRACTURE) can differentiate osteophytes from disc herniations in patients with cervical radiculopathy: a feasibility study","authors":"Dongmei Jiang ,&nbsp;Junhuan Hong ,&nbsp;Shuyi Lei ,&nbsp;Qiang Weng ,&nbsp;Ruiquan Chen ,&nbsp;Xiance Zhao ,&nbsp;Dejun She ,&nbsp;Dairong Cao","doi":"10.1016/j.ejrad.2025.112243","DOIUrl":"10.1016/j.ejrad.2025.112243","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic performance of fast-field-echo resembling a CT using restricted echo-spacing (FRACTURE) for differentiating cervical osteophytes and disc herniations.</div></div><div><h3>Materials and methods</h3><div>Patients suspected of cervical radiculopathy (CR) with FRACTURE, conventional MRI, and CT scans were retrospectively included between October 17, 2023 and July 24, 2024. A total of 43 patients (20 women, 23 men; mean age, 57.3 ± 1.8 years) were enrolled and 516 intervertebral foramina were analyzed from bilateral C2/3 to C7/T1 on sagittal images. CT combined with MRI was the reference standard to identify osteophytes and disc herniations. The diagnostic performance of different images for identifying osteophytes and disc herniations was evaluated. The inter-modality differences, correlations, and agreements were assessed by measuring the sizes of osteophytes and disc herniations.</div></div><div><h3>Results</h3><div>For osteophytes, the sensitivity and specificity of FRACTURE were 94.7 % and 98.9 %, respectively; the area under the curve (AUC) of FRACTURE (AUC = 0.968) was significantly higher than that of T1WI (AUC = 0.688) and T2WI (AUC = 0.738). For disc herniations, the sensitivity and specificity of FRACTURE were 95.6 % and 99.2 %, respectively; the AUC of FRACTURE (AUC = 0.974) was also significantly higher than that of T1WI (AUC = 0.855) and T2WI (AUC = 0.864). A strong correlation (<em>R</em>² = 0.84) and an excellent agreement (ICC = 0.917) were achieved between FRACTURE and CT for osteophytes measurements. Strong correlations and excellent agreements were also obtained for disc herniations measurements between FRACTURE and T1WI (<em>R</em>² = 0.82, ICC = 0.990)/T2WI (<em>R</em>² = 0.92, ICC = 0.951).</div></div><div><h3>Conclusions</h3><div>FRACTURE enables the reliable differentiation of osteophytes and disc herniations in patients with CR.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112243"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of photon counting detector CT for coronary artery disease diagnostics: A Finnish healthcare perspective","authors":"Mikael A.K. Brix ,&nbsp;Marjo Okkonen ,&nbsp;Timo Mäkelä ,&nbsp;Marko Nikki ,&nbsp;Marko Korhonen ,&nbsp;Miika T. Nieminen","doi":"10.1016/j.ejrad.2025.112245","DOIUrl":"10.1016/j.ejrad.2025.112245","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to evaluate the cost-effectiveness of photon-counting detector computed tomography (PCD-CT) compared to energy-integrating detector CT (EID-CT) for coronary artery disease (CAD) diagnostics in the Finnish healthcare context.</div></div><div><h3>Methods</h3><div>Two decision trees, incorporating local cost data and diagnostic pathways, were developed based on previously published Coronary Artery Disease – Reporting and Data System reclassification data for PCD-CT and EID-CT. A bootstrapping Monte Carlo simulation was used to model 10,000 virtual patients across a 10-year scanner lifespan. Two diagnostic scenarios were considered: one based on the diagnostic pathway of a previously published study (scenario 1) and another reflecting local clinical practice (scenario 2). Downstream testing costs and total diagnostic costs of both PCD-CT and EID-CT branches were assessed. The break-even point for PCD-CT investment was determined by including an assumed €1,500,000 price premium over EID-CT.</div></div><div><h3>Results</h3><div>PCD-CT significantly reduced downstream diagnostic testing compared to EID-CT. In scenario 1, mean downstream costs per patient were €377.1 ± 11.5 for PCD-CT and €569.7 ± 11.7 for EID-CT, (33.8 % reduction, p &lt; 0.001). In scenario 2, downstream costs were €831.7 ± 19.7 for PCD-CT and €1138.2 ± 18.3 for EID-CT (26.9 % reduction, p &lt; 0.001). Total diagnostic costs, including CCTA, were also lower with PCD-CT. The cost-benefit threshold was reached after 7,880 and 4,950 patients for scenarios 1 and 2 respectively.</div></div><div><h3>Conclusions</h3><div>PCD-CT would be a cost-effective alternative to EID-CT in high-volume centers, reducing unnecessary downstream tests through improved diagnostic accuracy. These findings support its adoption in Finnish healthcare systems.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112245"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of a deep learning image reconstruction algorithm for assessing vertebral compression fractures using dual-energy computed tomography","authors":"Jiayi Tang ,&nbsp;Luyou Yan ,&nbsp;Kun Zhang ,&nbsp;Suping Chen ,&nbsp;Ping Liu ,&nbsp;Jinling Wang ,&nbsp;Yewen He","doi":"10.1016/j.ejrad.2025.112244","DOIUrl":"10.1016/j.ejrad.2025.112244","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the value of deep learning image reconstruction (DLIR) in improving image quality of virtual non-hydroxyapatite (VNHAP) and virtual monoenergetic images (VMIs), and radiologists’ performance in detecting acute vertebral compression fractures (VCFs).</div></div><div><h3>Methods</h3><div>VMIs at 70 keV and VNHAP images from 103 vertebrae (46 normal vertebra, 29 acute and 28 chronic VCFs) were reconstructed with four algorithms: adaptive statistical iterative reconstruction (AR50), DLIR-Low (DL), DLIR-Middle (DM), and DLIR-High (DH). Objective indexes including CT values for 70 keV VMIs and water density for VNHAP images, noise, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR] of all vertebral bodies, as well as intervertebral ratio [IVR] of acute and chronic VCFs. Subjective image quality scoring and VCFs diagnosis were independently performed by four radiologists. Employing MR examinations as the reference, the specificity, sensitivity, accuracy, and predictive metrics for detecting acute VCFs were assessed.</div></div><div><h3>Results</h3><div>DLIR reduced image noise and improved SNR and CNR for all vertebra on both 70 keV VMIs and VNHAP images. DH-reconstructed VNHAP images had the highest IVR for acute VCFs and outperformed for all comparisons. The four-reader subjective scores on image quality: DH &gt; DM &gt; DL &gt; AR50. For the differentiation between acute and chronic VCFs, the four readers with VNHAP images showed enhanced performance than those with 70 keV VMIs, while DLIR further improved the efficiency, with DH performed the best.</div></div><div><h3>Conclusion</h3><div>DLIR improved the quality of VMIs and VNHAP images, elevated the contrast of acute VCFs, and enhanced radiologists’ performance in detecting acute VCFs. DH performed the best.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112244"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth-in-eye standardized longitudinal radiological CT monitoring: Clinical impact in a fourteen-year series","authors":"Zhuyi Rebekah Lee ,&nbsp;Felicia Teo ,&nbsp;Sharon Kuan ,&nbsp;Evan C Edmond ,&nbsp;Stephanie Fook-Chong ,&nbsp;Robert Chun Chen ,&nbsp;Jean Chai ,&nbsp;Andrew Tay ,&nbsp;Donald Tan ,&nbsp;Ling Ling Chan","doi":"10.1016/j.ejrad.2025.112242","DOIUrl":"10.1016/j.ejrad.2025.112242","url":null,"abstract":"<div><h3>Purpose</h3><div>Report the natural history of laminar resorption quantitatively and qualitatively on serial CT after sight-restoring osteo-odonto-keratoprosthesis (OOKP) surgery, conduct OOKP survival analysis, and describe how standardized CT monitoring using a three-prong approach aids clinical evaluation and management, including decision-making for prophylactic OOKP exchange.</div></div><div><h3>Method</h3><div>CT data of OOKPs consecutively recruited over a 14-year period since program inception were retrospectively evaluated for laminar resorption on (1) linear measurements, (2) volumetry, (3) cross-sectional imaging and three-dimensional rendering. Findings in relation to ophthalmic complications on clinical follow-up were described, and OOKP Kaplan-Meier survival analysis performed.</div></div><div><h3>Results</h3><div>40 OOKPs (38 patients, mean age 39.9 years, 22 men) underwent a total of 197 serial CTs (average 3.9 scans per OOKP at 1.4-year intervals over 5.5-year follow-up). They charted a wide time range to first significant CT resorption (4.7 months-10.0 years): median time 3.6 years, and moderate/severe resorption &lt; 5 years in 8/9 (88.9 %) OOKPs. Survival analysis showed steady laminar resorption beyond 2.3 years in Stevens-Johnson syndrome (SJS) patients, compared to less progressive resorption in non-SJS patients. Manual linear measurements were more sensitive than automated volumetry to laminar resorption, especially for the more commonly affected thinner and superior/inferior poles. Moderate/severe resorption culminated in OOKP failure and ocular loss in three patients; two showed preceding telltale <em>peri</em>-optic erosions despite clinical stability. Three other patients underwent prophylactic OOKP exchange to salvage vision.</div></div><div><h3>Conclusions</h3><div>Lifelong, standardized three-prong CT monitoring for OOKP resorption value-adds to clinical evaluation, assisting decision-making for early intervention to avert irrevocable blindness.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112242"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI capacity assessment for prostate cancer screening in five sites of Europe","authors":"Deependra Singh ,&nbsp;Arunah Chandran ,&nbsp;Valeria Panebianco ,&nbsp;Josep Vilaseca ,&nbsp;Ausvydas Patasius ,&nbsp;Krzysztof Tupikowski ,&nbsp;Ángel Gómez Amorín ,&nbsp;David Galvin ,&nbsp;Roderick C.N. van den Bergh ,&nbsp;Monique J. Roobol ,&nbsp;Lionne D.F. Venderbos ,&nbsp;Sarah Collen ,&nbsp;Hendrik van Poppel ,&nbsp;Partha Basu ,&nbsp;Milagros Otero-García","doi":"10.1016/j.ejrad.2025.112235","DOIUrl":"10.1016/j.ejrad.2025.112235","url":null,"abstract":"<div><div>Recognizing prostate cancer (PCa) as a significant public health challenge, the European Union, in 2022, recommended for organized screening programs incorporating PSA testing with MRI for risk stratification. This study assessed the MRI capacity and readiness of five pilot implementation sites in Europe within the PRostate cancer Awareness and Initiative for Screening Europe (PRAISE-U) project: Lithuania, Poland, Ireland, and two Spanish regions (Manresa and Galicia). Data included MRI types, waiting times, diagnostic quality, radiologist experience, and referral pathways. All pilot sites integrated multiparametric MRI (mpMRI) and biparametric MRI (bpMRI) for risk stratification before prostate biopsy. MRI capacity and readiness for PCa screening across pilot implementation sites demonstrate consistent use of MRI for risk stratification and high diagnostic quality. Some difference in facility infrastructure, radiologist’s expertise, and MRI protocols reflect diverse healthcare systems. Future comparison of bpMRI and mpMRI in real-time screening settings will provide critical evidence for scaling the program. Standardizing MRI protocols and PSA assays across pilot sites is essential to ensure quality and consistency. The PRAISE-U project will deliver valuable insights into the feasibility and scalability of MRI-based PCa screening programs across Europe.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112235"},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}