European Journal of Radiology最新文献

{"title":"Association between free water and longitudinal dynamics of recent small subcortical infarcts: a study based on diffusion tensor imaging","authors":"Tiantian Qiu ,&nbsp;Hui Hong ,&nbsp;Fuzhou Li ,&nbsp;Lige Zhang ,&nbsp;Yuan Xu ,&nbsp;Xiaopei Xu ,&nbsp;Qingze Zeng ,&nbsp;Xinfeng Yu ,&nbsp;Peiyu Huang ,&nbsp;Ruiting Zhang ,&nbsp;Fei Xie ,&nbsp;Shouping Dai ,&nbsp;Yusong Zhang ,&nbsp;Xiao Luo","doi":"10.1016/j.ejrad.2025.112395","DOIUrl":"10.1016/j.ejrad.2025.112395","url":null,"abstract":"<div><div>The mechanisms underlying the different morphological evolution of recent small subcortical infarcts (RSSIs)—ranging from cavitation to complete disappearance—remain incompletely understood. Free water (FW), derived from diffusion tensor image, has emerged as a sensitive marker reflecting various pathophysiological processes that may influence RSSI evolution. This study aimed to investigate whether baseline FW measures and their longitudinal changes are associated with the morphological evolution of RSSIs. We prospectively enrolled 42 RSSI patients who underwent comprehensive clinical assessments and magnetic resonance imaging scans at baseline and the 1-year follow-up. FW values were calculated for the lesion, ipsilesional white matter (WM), and contralesional WM, as well as the longitudinal changes in FW within ipsilesional and contralesional WM. Linear regression analyses were performed to examine the associations between FW measures and RSSI cavitation, as well as between cavitation and long-term changes in functional and cognitive outcomes. At the 1-year follow-up, 86 % of RSSIs showed some degree of cavitation and 14 % showed complete disappearance on 3D T1 sequence, with a median cavitation proportion of 10 %. We found that higher baseline ipsilesional WM FW was significantly associated with a greater proportion of RSSI cavitation (β = 0.459, <em>p</em> = 0.015). However, cavity formation was not correlated with changes in functional or cognitive outcomes at the 1-year follow-up. Our findings suggest that baseline ipsilesional WM FW may serve as a sensitive imaging biomarker associated with cavity formation in RSSIs. Given the exploratory nature of this study, future research involving larger sample sizes and longer follow-up periods is needed to further elucidate the relationship between cavity formation and clinical outcomes.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112395"},"PeriodicalIF":3.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The central dorsal component of the dorsoradial ligament of the trapeziometacarpal joint: Cadaveric and sonographic validation","authors":"Víctor Margüenda-Fernández ,&nbsp;Fermín Valera-Garrido ,&nbsp;Francisco J. Valderrama-Canales ,&nbsp;Francisco Minaya-Muñoz ,&nbsp;Pablo Herrero ,&nbsp;Diego Lapuente-Hernández","doi":"10.1016/j.ejrad.2025.112398","DOIUrl":"10.1016/j.ejrad.2025.112398","url":null,"abstract":"<div><h3>Purpose</h3><div>Osteoarthritis of the trapeziometacarpal joint is very common, especially in females, and is closely associated with ligamentous laxity and joint subluxation. The dorsoradial ligament (DRL) remains largely unexplored in ultrasound studies despite its clinical relevance. This study aimed to identify the central fascicle of the DRL anatomically and ultrasonographically and to establish a standardized ultrasound examination protocol.</div></div><div><h3>Methods</h3><div>This observational cross-sectional validation study was conducted in two phases. First, anatomical dissections were performed on five cadaveric specimens to define anatomical landmarks and guide the development of an ultrasound protocol. In the second phase, bilateral ultrasound examinations were performed on the thumbs of 26 healthy participants (n = 52) to assess ligament morphology and establish normative measurements.</div></div><div><h3>Results</h3><div>The DRL was successfully identified in all cases, and ultrasound imaging allowed for the reproducible visualization of its central fascicle. The mean joint distance was 0.36 ± 0.13 cm, and the mean ligament area was 0.20 ± 0.08 cm². Significant differences were observed between the sexes, with males having statistically higher distances (p &lt; 0.05) than females from the tubercle of the trapezium to the skin and from the tubercle of the trapezium to the upper edge of the first metacarpal. However, no significant correlations were found with age, and no significant asymmetries were found between both sides.</div></div><div><h3>Conclusion</h3><div>The DRL can be reliably assessed by ultrasound and provides clinically relevant parameters to assess ligament morphology. The standardized protocol developed provides a valuable tool for detecting ligamentous insufficiency and capsuloligamentous changes. These findings contribute to understanding the anatomy and function of the DRL and provide a basis for future research into its role in joint stability and osteoarthritic progression.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112398"},"PeriodicalIF":3.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive performance of distinct skeletal muscle index cut-offs-defined sarcopenia for long-term mortality in decompensated cirrhosis: A prospective observational study","authors":"Chao Sun ,&nbsp;Han Wang ,&nbsp;Ziyi Yang ,&nbsp;Huanli Jiao","doi":"10.1016/j.ejrad.2025.112396","DOIUrl":"10.1016/j.ejrad.2025.112396","url":null,"abstract":"<div><h3>Purpose</h3><div>Although the clinical implication of sarcopenia has been verified in the context of cirrhosis, there is limited data concerning cut-offs of CT-measured skeletal muscle index (SMI) across different ethnicities. We aimed to compare the predictive performance of distinct SMI values-defined sarcopenia for prognosis in cirrhosis.</div></div><div><h3>Methods</h3><div>Totally, 478 inpatients due to cirrhosis-associated acute insults were prospectively enrolled. A range of cut-offs concerning SMI (Tianjin, northernChina, southernChina, Japan and Turkey criteria) were testified to determine 2-year all-cause mortality according to the Kaplan-Meier survival curve and multivariate Cox regression model.</div></div><div><h3>Results</h3><div>Sarcopenia was diagnosed in 24.3 %, 6.3 %, 21.1 %, 29.1 % and 6.5 %, respectively, according to Tianjin, northernChina, southernChina, Japan and Turkey criteria. Survival analysis showed marked differences between patients with and without sarcopenia defined by all aforesaid criteria (log-rank test: P &lt; 0.05). Univariate Cox regression indicated that age, Child-Turcotte-Pugh (CTP) class, Model for End-stage Liver Disease-Sodium (MELD-Na), creatinine, bilirubin, white blood cell count, prothrombin time-international normalized ratio, sodium, albumin, ascites, hepatic encephalopathy, infection and sarcopenia were significantly associated with mortality. Further multivariate model fully adjusting age, BMI and MELD-Na/CTP class revealed that all criteria-defined sarcopenia was independently associated with mortality, except for the Turkey criteria.</div></div><div><h3>Conclusions</h3><div>Our findings provide supporting evidence to develop continent-based SMI cut-offs in hopes of identifying sarcopenic patients with cirrhosis, taking its impact on mortality and morbidity into consideration.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112396"},"PeriodicalIF":3.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of CT Colonography in the assessment of inflammatory bowel Diseases patients","authors":"Mariani Leonardo ,&nbsp;Colombo Francesco ,&nbsp;Meuli Sarah ,&nbsp;Zaffaroni Gloria ,&nbsp;Danelli Piergiorgio ,&nbsp;Maconi Giovanni ,&nbsp;Ianniello Andrea ,&nbsp;Flor Nicola","doi":"10.1016/j.ejrad.2025.112397","DOIUrl":"10.1016/j.ejrad.2025.112397","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract, and its long-standing course significantly elevates the risk of colorectal cancer (CRC), primarily arising from dysplastic lesions. While regular surveillance by colonoscopy is well established for UC patients, guidelines for CD remain uncertain.</div><div>Computed Tomographic Colonography (CTC) offers a minimally invasive alternative for evaluating the colon, particularly in cases where colonoscopy is incomplete or contraindicated. Although not commonly utilized in IBD management, CTC provides substantial advantages in identifying complications such as fistulas, strictures, and colonic neoplasms. Additionally, it offers anatomical detail, which is crucial for surgical planning and decision-making.</div><div>In this review we aim to demonstrate the usefulness of CTC in selected IBD cases, particularly in patients for whom colonoscopy is not feasible, and to show how its integration into clinical practice enhances decision-making and provides crucial insights into disease complications.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112397"},"PeriodicalIF":3.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of rectal MRI prior to endoscopic submucosal dissection (ESD): an exploratory study","authors":"Marc J. Gollub ,&nbsp;Maria Clara Fernandes ,&nbsp;Wyanne Law ,&nbsp;Makoto Nishimura ,&nbsp;Lee Rodriguez ,&nbsp;Sayaka Nagao ,&nbsp;Jinru Shia ,&nbsp;Julio Garcia-Aguilar ,&nbsp;Martin R Weiser ,&nbsp;Junting Zheng ,&nbsp;Marinela Capanu","doi":"10.1016/j.ejrad.2025.112400","DOIUrl":"10.1016/j.ejrad.2025.112400","url":null,"abstract":"<div><h3>Purpose</h3><div>To correlate rectal MRI findings with endoscopic margin status and depth of invasion in patients undergoing endoscopic submucosal dissection (ESD) for rectal adenomas and early rectal cancers.</div></div><div><h3>Methods</h3><div>Pre-treatment MRIs of patients with colonoscopy-detected polyps and early rectal cancer undergoing curative-intent ESD from 2018 to 2023 were re-interpreted by two radiologists (3- and 25-years’ experience) blinded to outcomes. MRI features assessed included largest and smallest length, T2 signal intensity, degree of wall attachment, diffusion restriction and apparent diffusion coefficient values. The reference standard was histopathology. Associations between MRI features and outcomes were tested with Fisher’s exact test and Wilcoxon rank sum test. Inter-rater agreement was assessed with kappa statistics and intraclass correlation coefficient.</div></div><div><h3>Results</h3><div>In 21 patients (median age, 64 years [interquartile range, 54–75]; 12 (57 %) female), final ESD histopathology showed 12 (57 %) adenocarcinomas and 9 (43 %) adenomas. R0 resections were achieved in 11/21 ESD procedures (52.3 %, 95 % CI: 30–74 %). Depth of invasion was correct in 6/21 and 5/21 cases (29 % and 24 %, 95 % CI: 11–52 % and 8–47 %), for 2 readers, respectively. Significant associations with R0 resection for both readers included: smaller mass size (long axis; p = 0.005, 0.003, short axis; p = 0.018, 0.022) and lower degree of wall attachment (p = 0.001, 0.011). Agreement on these three measures was good to low (ICC = 0.87, 0.80, and 0.39), respectively.</div></div><div><h3>Conclusions</h3><div>In this hypothesis-generating exploration of MRI findings of adenomas and early rectal cancers undergoing ESD, MRI polyp size and degree of wall attachment showed strong negative associations with tumor-free resection margins.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112400"},"PeriodicalIF":3.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of warming gadoxetic acid on arterial-phase artifacts in dynamic liver MRI: A prospective single-center study","authors":"Keisuke Ishimatsu ,&nbsp;Akihiro Nishie ,&nbsp;Yasuhiro Ushijima ,&nbsp;Daisuke Okamoto ,&nbsp;Nobuhiro Fujita ,&nbsp;Kosuke Tabata ,&nbsp;Satoshi Makise ,&nbsp;Shogo Hino ,&nbsp;Kousei Ishigami","doi":"10.1016/j.ejrad.2025.112384","DOIUrl":"10.1016/j.ejrad.2025.112384","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate whether warming gadoxetic acid affects the frequency and degree of artifacts in the arterial phase of MRI.</div></div><div><h3>Methods</h3><div>This prospective study included patients who underwent gadoxetic acid-enhanced MRI (April 2016−November 2017 and June−November 2018) at a single center. Either warmed (37 °C, n = 134) or non-warmed (24 °C, n = 137) gadoxetic acid was intravenously injected at a dose of 0.025 mmol/kg for 5 s. Breath-hold time for each phase was fixed at 20 s. Artifact severity was graded using a four-point scale. Patient background and artifact scores in precontrast, arterial, and portal phases were compared between groups.</div></div><div><h3>Results</h3><div>Two hundred and seventy-one patients (mean age 64 ± 14 years, 149 male) were included. Patient background including the presence of pleural effusion, ascites, cirrhosis, and pulmonary disease, did not differ significantly between the two groups. The mean artifact score in the arterial phase was significantly lower in the 37 °C group than in the 24 °C group (1.4 ± 0.8 vs. 1.6 ± 0.9, <em>p</em> = 0.017), whereas no significant difference was observed in the precontrast and portal phases. The rate of substantial artifact (score = 3 or 4) in the arterial phase was significantly lower in the 37 °C group than in the 24 °C group (11.2 % vs. 21.1 %, <em>p</em> = 0.031). The number of patients with high artifact scores in the arterial phase compared to those in the precontrast image was also lower in the 37 °C group than in the 24 °C group (21.6 % vs. 36.0 %, <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Warmed gadoxetic acid could reduce artifacts in the arterial phase of dynamic MRI.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112384"},"PeriodicalIF":3.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of generic and individual justification: Findings from a survey under the IAEA technical cooperation programme in Europe and Central Asia","authors":"D. Faj ,&nbsp;D. Žontar ,&nbsp;D. Remedios ,&nbsp;J. Chabukovska-Radulovska ,&nbsp;I. Kralik ,&nbsp;T. Sera ,&nbsp;J. Ziliukas ,&nbsp;V. Gershan ,&nbsp;J. Vassileva","doi":"10.1016/j.ejrad.2025.112381","DOIUrl":"10.1016/j.ejrad.2025.112381","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study is to evaluate the framework and practice of generic and individual justification in countries from the Europe and Central Asia Region supported by the technical cooperation programme (TC) of the International Atomic Energy Agency (IAEA).</div></div><div><h3>Methods</h3><div>The information was obtained by four electronic questionnaires using Google Forms during the 2024. One was distributed to regulatory bodies and three to professional bodies of radiology, nuclear medicine, and dental medicine. The links were sent by mail to representatives from 33 IAEA TC Members States in the region, and a total 85 responses were received from representatives in 24 countries.</div></div><div><h3>Results</h3><div>Respondents report availability of referral guidelines in only 55–70 % of countries but, where available, guidelines usually include radiation doses and guidance for children and pregnant patients. Clinical information provided by referring practitioners is lacking both for the clinical question and for information from previous procedures, with questions raised as to the completeness of clinical examination before requesting imaging. Radiologists’ unencumbered ability to modify or reject a referral for computed tomography was reported by only 13/18 countries (72 %). Underlying issues include difficulties with communication and cooperation between regulatory bodies and professional bodies, limited understanding of regulatory requirements among medical professionals, and limited understanding of clinical practice by regulatory bodies. Good practices in justification were shown in EU countries possibly related to stronger regulation and provision of better clinical information.</div></div><div><h3>Conclusions</h3><div>Justification problems in the Europe and Central Asia IAEA TC countries, similar to other regions include: low availability and use of referral guidelines; inadequate clinical information for justification; limited time and ability for radiological medical practitioners to amend or reject inappropriate requests; and suboptimal cooperation and communication between regulatory authorities and professionals. Strategies for improvement should address these and may include stronger regulation and better mutual awareness between regulators and professionals, possibly through continuing education, campaigns and collaborative working.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112381"},"PeriodicalIF":3.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable radiomics model based on dual-layer spectral CT iodine maps for predicting microsatellite instability in colorectal cancer: A two-center study","authors":"Weicui Chen ,&nbsp;Ziqi Jia ,&nbsp;Ling Wan ,&nbsp;Wenjing Yuan ,&nbsp;Jiaqi Xu ,&nbsp;Xiaohua Du ,&nbsp;Yuankui Wu ,&nbsp;Xiaomin Liu ,&nbsp;Xian Liu ,&nbsp;Zhibo Wen","doi":"10.1016/j.ejrad.2025.112357","DOIUrl":"10.1016/j.ejrad.2025.112357","url":null,"abstract":"<div><h3>Purpose</h3><div>To develop and validate an interpretable radiomics model using dual-layer detector spectral CT (DLSCT)-derived iodine maps to preoperatively predict Microsatellite instability (MSI) status in colorectal cancer (CRC).</div></div><div><h3>Method</h3><div>A total of 255 CRC patients who underwent DLSCT were retrospectively included from two independent centers. Tumor iodine concentrations (IC) and normalized iodine concentrations (NIC) were measured and calculated. Iodine maps were analyzed to extract radiomics features. Clinical, radiomics, and combined clinical- radiomics models were constructed respectively. Model performance was evaluated using receiver operating characteristic curve and decision curve analysis. SHapley Additive exPlanation (SHAP) was employed to enhance interpretability.</div></div><div><h3>Results</h3><div>Overall, 255 patients (mean 60.5 ± 12.9 years; 122 males) were divided into training (n = 149), internal testing (n = 60), and independent external testing (n = 46) sets. High-level MSI (MSI-H) status was present in 38 patients (14.9 %). CRC with microsatellite instability-low or microsatellite stability exhibited higher IC values in the arterial phase and NIC in the venous phase than those in MSI-H patients (<em>p</em> &lt; 0.05). For MSI prediction, the clinical- radiomics models outperformed the clinical model (AUC = 0.84 vs 0.67, <em>p</em>＜0.001). Decision curve analysis confirmed the higher net benefit of the clinical- radiomics model compared to the other models across probability thresholds ranging from 0 to 0.40. SHAP analysis highlighted a wavelet-based feature and a shape feature as key contributors.</div></div><div><h3>Conclusions</h3><div>The interpretable clinical-radiomics model based on iodine maps effectively predicts MSI status in CRC preoperatively, facilitating personalized decision-making in clinical practice.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112357"},"PeriodicalIF":3.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal post-contrast timing for photon-counting CT-based myocardial extracellular volume quantification in a swine model: Cardiac magnetic resonance as the reference","authors":"Shouyu Bao ,&nbsp;Min Yang ,&nbsp;Peng Liu ,&nbsp;Zhihan Xu ,&nbsp;Shixing Huang ,&nbsp;Fuhua Yan ,&nbsp;Wenjie Yang","doi":"10.1016/j.ejrad.2025.112383","DOIUrl":"10.1016/j.ejrad.2025.112383","url":null,"abstract":"<div><h3>Rationale and Objectives</h3><div>Advances in computed tomography (CT) have enabled myocardial extracellular volume (ECV) quantification, but the optimal post-contrast timing for CT-derived ECV remains undefined. In this preclinical study using a swine model, we aimed to determine the optimal post-contrast acquisition time for photon-counting CT (PCCT)-derived ECV using cardiac magnetic resonance (CMR) as the reference standard.</div></div><div><h3>Materials and Methods</h3><div>Twenty-three CMR and PCCT scans were performed on infarcted swine, and nine scans on healthy controls. PCCT scans were acquired at 3-, 5-, 7-, 9-, 12-, and 15-minutes after contrast administration. Pearson correlation coefficients (r) and intraclass correlation coefficients (ICCs) were calculated between PCCT- and CMR-derived ECV across all myocardial segments, infarcted and normal myocardium. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of PCCT-ECV in differentiating LGE-positive from LGE-negative myocardial segments. Subgroup analyses were conducted based on heart rate (HR).</div></div><div><h3>Results</h3><div>Across all segments, r ranged from 0.79 to 0.91 and ICCs from 0.88 to 0.95 and the area under the ROC curve (AUC) values ranged from 0.799 to 0.847 (all p &lt; 0.001). Peak correlation and agreement occurred at 5 min (r = 0.91; ICC = 0.95, 95 % CI: 0.92–0.96), with similarly high values at 3 and 7 min (r = 0.90; ICC = 0.93 and 0.94, respectively), followed by a gradual decline. At elevated HRs (&gt;84 bpm), PCCT still maintained robust agreement with CMR (ICC = 0.78–0.92) and satisfactory diagnostic performance (AUC values ranged from 0.677 to 0.777).</div></div><div><h3>Conclusion</h3><div>PCCT enables accurate and consistent ECV quantification with strong concordance to CMR from 3 to 7 min post-contrast in swine models, providing a wide temporal window for clinical scanning. This was further confirmed by ROC analysis, and the method demonstrated robustness across varying heart rates.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112383"},"PeriodicalIF":3.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based detection of ascending aortic dilatation on chest radiographs: A diagnostic study","authors":"Hyeyun Lee ,&nbsp;Gwisang Park ,&nbsp;Chankue Park ,&nbsp;Jiyun Ok ,&nbsp;Whal Lee ,&nbsp;Sung Mok Kim ,&nbsp;Ming-Ting Wu ,&nbsp;Ki Seok Choo","doi":"10.1016/j.ejrad.2025.112380","DOIUrl":"10.1016/j.ejrad.2025.112380","url":null,"abstract":"<div><h3>Objectives</h3><div>This study externally tests the performance of an artificial intelligence algorithm (AI) for diagnosing ascending aortic dilatation (AAD) using PA view chest radiography (PA CXR).</div></div><div><h3>Materials and methods</h3><div>Two retrospectively collected cohorts with paired CXR/CT within 30 days (Group 1) and 90 days (Group 2) were gathered as external test sets. The performance of AI (DeepCatch X Aorta v1.1.0) for detecting AAD using PA CXR was analyzed against semi-automatic measurements on CT using fixed thresholds (4.0, 4.5, and 5.0 cm) and subjective assessment (dilatation or no dilatation) of 2 cardiovascular radiologists (&gt;20 years’ experience) and 3 less-experienced (&lt;2 years’ experience) doctors. Additionally, modified thresholds accounting for radiographic magnification were analyzed in the Group 1. Performance metrics (sensitivity, specificity, and AUC) and inter-reader agreement were used.</div></div><div><h3>Results</h3><div>Group 1 included 336 scans (mean age = 64 years) and Group 2 had 190 scans (mean age = 70 years). Dilatation (≥4 cm) was present in 182 patients (Group 1) and 94 patients (Group 2). The algorithm demonstrated robust performance in both Groups for the ≥4 cm threshold, with AUC of 0.89 (95 % CI: 0.85, 0.92) in Group 1 and 0.88 (95 % CI: 0.83, 0.92) in Group 2. All readers’ performances were under the AUC of AI at 4 cm threshold. Inter-reader agreement was fair to moderate (Cohen’s kappa, Group 1, 0.38; Fleiss's kappa, Group 2, 0.37).</div></div><div><h3>Conclusion</h3><div>The AI algorithm detected AAD from a single PA CXR with robust AUC over 0.8 across different clinical thresholds and cohorts, outperforming human readers.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112380"},"PeriodicalIF":3.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}