European Journal of Radiology最新文献

{"title":"CT derived myocardial extracellular volume predict major adverse cardiovascular events in patients with prostate cancer","authors":"Xinyu Zhang ,&nbsp;Hesong Shen ,&nbsp;Qian Xu ,&nbsp;Chunrong Tu ,&nbsp;Yangling Peng ,&nbsp;Tao Liu ,&nbsp;Xun Qiu ,&nbsp;Jiuquan Zhang","doi":"10.1016/j.ejrad.2025.112371","DOIUrl":"10.1016/j.ejrad.2025.112371","url":null,"abstract":"<div><h3>Background</h3><div>Prostate cancer (PCa) patients with androgen deprivation therapy (ADT) are at high risk for cardiotoxicity and major adverse cardiovascular events (MACE). It is unclear whether the myocardial extracellular volume (ECV) derived from chest contrast-enhanced CT (CECT) can detect cardiotoxicity and predict MACE in these patients. This work aimed to assess the value of chest CECT derived myocardial ECV for detecting cardiotoxicity and the association of ECV with MACE in PCa patients receiving ADT.</div></div><div><h3>Methods</h3><div>PCa patients with ADT between December 1, 2014 and March 31, 2020 were retrospectively included. Chest CECT derived myocardial ECV was obtained before ADT and approximately 3, 6, 9, and 12 months after ADT initiation. The differences in myocardial ECV between the MACE (+) and MACE (−) groups were analyzed by Student’s <em>t</em>-test, and the association between myocardial ECV and MACE was analyzed using a Cox proportional hazards model.</div></div><div><h3>Results</h3><div>In total, 180 patients were included, of whom 44 patients developed MACE. Myocardial ECV was significantly higher after 3 months of ADT than at baseline and peaked after 12 months of ADT. Moreover, the myocardial ECV of the MACE (+) group was higher than that of the MACE (−) group at each follow-up visit. A higher ECV at 3, 6, and 9 months after ADT was associated with an increased risk for MACE (adjusted hazard ratios were 2.695, 3.670, and 4.450, respectively).</div></div><div><h3>Conclusion</h3><div>Myocardial ECV derived from chest CECT can be used to dynamically monitor cardiotoxicity and predict MACE in patients with PCa receiving ADT.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112371"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-automatic and automatic segmentation in the preoperative assessment of graft volume before living donor liver transplantation","authors":"Dinara Baiguissova ,&nbsp;Yerkezhan Kalshabay ,&nbsp;Michele Di Martino ,&nbsp;Galina Battalova ,&nbsp;Aigerim Mukhamejanova ,&nbsp;Assan Kabidenov ,&nbsp;Daniyar Mukazhanov ,&nbsp;Yermek Akhmetov ,&nbsp;Bolatbek Baimakhanov","doi":"10.1016/j.ejrad.2025.112367","DOIUrl":"10.1016/j.ejrad.2025.112367","url":null,"abstract":"<div><h3>Objectives</h3><div>Accurate preoperative liver volumetry is essential for successful living donor liver transplantation (LDLT). Manual CT volumetry is time-consuming and operator-dependent, prompting the development of semi −automated and automated methods. The aim of this study is to compare the accuracy of one semi-automated (Vitrea, Canon) and two automated (Synapse, Fujifilm and United Imaging, UI) CT volumetry workstations in estimating liver graft volume of the right lobe, left lobe, and left lateral segment relative to intraoperative graft weight.</div></div><div><h3>Methods</h3><div>This retrospective study included 95 living liver donors (67 right lobe, 12 left lobe, and 16 left lateral segments) who underwent LDLT from 2022 to 2024. Estimated graft volumes were compared with actual graft weight (AGW). Correlation, percentage error, interobserver agreement, and potential influences of donors’ age and gender on estimation accuracy were assessed.</div></div><div><h3>Results</h3><div>All three methods demonstrated strong correlation with AGW (p &lt; 0.001). Application Liver Analysis of the workstation Synapse showed significantly higher accuracy in the right lobe volume estimation compared to the others (p &lt; 0.001), as well as in the left lateral segment estimation compared to Vitrea (p &lt; 0.001) and UI (p = 0.006). Interobserver agreement was high, and no significant influence of donors’ age or gender was found.</div></div><div><h3>Conclusion</h3><div>All three volumetry tools are reliable and user-friendly for preoperative planning for LDLT. Among them, Liver Analysis of Synapse demonstrated the highest accuracy in assessing right lobe and left lateral sector volumes, offering potential advantages in surgical decision-making.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112367"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphase MRI-Derived Delta radiomics integrated with clinical features for survival prediction in hepatocellular carcinoma after thermal ablation","authors":"Junpeng Luo ,&nbsp;Hao Xin ,&nbsp;Yandan Wang ,&nbsp;Xiang He","doi":"10.1016/j.ejrad.2025.112368","DOIUrl":"10.1016/j.ejrad.2025.112368","url":null,"abstract":"<div><h3>Rationale and objectives</h3><div>To evaluate the predictive value of a delta radiomic score (DRS)derived from multiphase contrast-enhanced Magnetic Resonance Imaging (MRI), in combination with clinical characteristics, forecasting overall survival (OS) and recurrence-free survival (RFS) in patients with hepatocellular carcinoma (HCC) after thermal ablation.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study enrolled 415 patients with HCC from two centers who underwent multiphase contrast-enhanced magnetic resonance imaging and percutaneous thermal ablation. Patients in Institution 1 (n = 315) were randomly assigned to the training cohorts (n = 220) and internal tests (n = 95), while 100 patients in Institution 2 formed the external validation cohort. Delta radiomic features were extracted by comparing contrast-enhanced phases with noncontract images, followed by variance filtering, correlation analysis, random forest ranking, and Cox regression to derive the DRS. The DRS was combined with clinical characteristics, including tumor burden score (TBS), Barcelona Clinic Liver Cancer (BCLC), and China Liver Cancer Staging (CNLC), to build Random Survival Forest (RSF) models. The performance of the model was evaluated using the concordance index (C-index), the area under the curve (AUC), the calibration curves and the analysis of decision curves (DCA).</div></div><div><h3>Results</h3><div>The RSF models that integrate DRS with clinical characteristics demonstrated favorable predictive performance for both OS and RFS. For OS predictions at 36 and 60 months, AUCs ranged from 0.71 to 0.83 in cohorts, with corresponding C indices between 0.69 and 0.83. For the prediction of short-term RFS at 6, 12, and 24 months, the AUC ranged from 0.71 to 0.91, with C-indices between 0.68 and 0.71. Calibration and DCA analysis confirmed the robustness and clinical utility of the models in internal and external validations.</div></div><div><h3>Conclusions</h3><div>Delta radiomics derived from multiphase MRI effectively captured tumor dynamics and heterogeneity. When integrated with clinical characteristics, the resulting models allowed an accurate prediction of both recurrence and long-term survival, providing a practical tool for risk stratification and individualized post-ablation management in HCC.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112368"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of early resistance to catheter-directed thrombolysis in patients with proximal deep vein thrombosis","authors":"Maofeng Gong,&nbsp;Cheng Qian,&nbsp;Xu He,&nbsp;Jianping Gu,&nbsp;Guoping Chen","doi":"10.1016/j.ejrad.2025.112370","DOIUrl":"10.1016/j.ejrad.2025.112370","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine predictors of immediate thrombolysis resistance (iTR) in patients with proximal deep vein thrombosis (DVT), defined as thrombosis involving the femoral or more proximal veins, with or without concomitant popliteal vein involvement, and to investigate its impact on long-term post-thrombotic syndrome (PTS) outcomes.</div></div><div><h3>Methods</h3><div>This single-center retrospective study reviewed consecutive patients who underwent catheter-directed thrombolysis (CDT) as first-line therapy. Baseline demographics, clinical history, comorbidities and provoking risk factors for DVT, intraprocedural findings, periprocedural complications, and follow-up outcomes were compared between the iTR and immediate thrombolysis success (iTS) groups.</div></div><div><h3>Results</h3><div>182 patients (median age, 59.5 years; 53.3 % female) were included, with an iTR incidence of 13.7 % (25/182). After adjusting for body mass index, age (adjusted odds ratio [aOR] 0.95; 95 % confidence interval [CI], 0.92–0.99; <em>p</em> = 0.007), cancer (aOR 9.19; 95 % CI, 2.17–38.86; <em>p</em> = 0.003), urokinase use (aOR 6.69; 95 % CI, 1.78–25.19; <em>p</em> = 0.005), and absence of popliteal venous inflow (aOR 0.15; 95 % CI, 0.04–0.50; <em>p</em> = 0.002) were independent predictors of iTR. The overall complication rate was 10.4 % (19/182), with no significant difference between two groups (<em>p</em> &gt; 0.05). At a median follow-up of 24 months, patients with iTR had a significantly higher incidence of PTS compared to those with iTS (hazard ratio 8.81; 95 % CI: 3.01–25.83; <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>CDT is beneficial for the majority of selected patients with proximal DVT and low bleeding risk. Younger age, cancer presence, urokinase use, and absence of popliteal venous inflow were independent predictors of iTR. iTR significantly increased the risk of developing long-term PTS.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112370"},"PeriodicalIF":3.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of detecting critical findings using abbreviated brain MRI scan protocols as a prerequisite for AI-driven on-the-fly scan protocol adaptation","authors":"Kaining Sheng ,&nbsp;Silvia Ingala ,&nbsp;Andreas Hjelm Brandt ,&nbsp;Natalia Grundtvig ,&nbsp;Ruta Jakubauskaite ,&nbsp;Rasmus Holmboe Dahl ,&nbsp;Bahareh Abdolalizadeh ,&nbsp;Emmanuel Nimpong ,&nbsp;Karen Larsen ,&nbsp;Lærke Lundgren ,&nbsp;Stefan Rovira Finnerup ,&nbsp;Thomas Truelsen ,&nbsp;Amine Korchi ,&nbsp;Akshay Pai ,&nbsp;Adam Espe Hansen ,&nbsp;Michael Bachmann Nielsen ,&nbsp;Jonathan Frederik Carlsen","doi":"10.1016/j.ejrad.2025.112365","DOIUrl":"10.1016/j.ejrad.2025.112365","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the performance of an AI tool and relevant radiology professionals in detecting brain infarcts, intracranial hemorrhages, and tumors using abbreviated brain MRI scan protocols as prerequisite for an AI-driven workflow that dynamically selects additional imaging sequences based on real-time imaging findings.</div></div><div><h3>Materials and methods</h3><div>A retrospective, consecutively enriched cohort of routine adult brain MRI scans from four Danish hospitals was constructed. Three consultant neuroradiologists, three radiology residents, three MR technologists, and an AI tool detected brain infarcts, hemorrhages, and tumors using an abbreviated 3-sequence protocol (DWI, SWI/T2*-GRE, T2-FLAIR) or 4-sequence protocol (DWI, SWI/T2*-GRE, T2-FLAIR, T1W) in a non-overlapping three-way split cross-over design. Reference findings were established from radiological reports and independent image reviews.</div></div><div><h3>Results</h3><div>A total of 414 patients were included (57 years ± 19, 238 men) with 65 confirmed brain infarcts, 65 hemorrhages, and 65 tumors. The AI tool achieved detection sensitivities of 94 % (61 of 65 scans, 95 %CI:85–98 %), 82 % (53 of 65 scans, 95 %CI:70–90 %), and 74 % (48 of 65 scans, 95 %CI:61–84 %) for brain infarcts, hemorrhages, and tumors, respectively, and corresponding specificities of 86 % (300 of 349 scans, 95 %CI:82–89 %), 84 % (293 of 349 scans, 95 %CI:80–88 %), and 62 % (217 of 349 scans, 95 %CI:57–67 %). The tool achieved sensitivities comparable to those of neuroradiologists using abbreviated scan protocols, and it surpassed MR technologists in tumor detection, though its specificities were lower.</div></div><div><h3>Conclusion</h3><div>The initial steps towards automated real-time scan adaptation are feasible and can potentially improve detection sensitivity, balancing reduced specificities compared to the current standard of care.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112365"},"PeriodicalIF":3.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of age on parameters of multiparametric functional renal MRI: A prospective exploratory study","authors":"Toni Rabadi,&nbsp;Luisa Kirchner,&nbsp;Antonia M. Pausch,&nbsp;Clara Elsner,&nbsp;Andreas M. Hötker","doi":"10.1016/j.ejrad.2025.112366","DOIUrl":"10.1016/j.ejrad.2025.112366","url":null,"abstract":"<div><h3>Introduction/objective</h3><div>To investigate the ability of multiparametric magnetic resonance imaging (mpMRI) to non-invasively assess the influence of aging on renal microstructure and function.</div></div><div><h3>Materials and methods</h3><div>This prospective, diagnostic, IRB-approved study included healthy volunteers over 18 years of age who underwent renal mpMRI at 3 Tesla. The mpMRI study protocols included T1, T2, and T2* mapping, arterial spin labeling, and intravoxel incoherent motion (IVIM) diffusion imaging. Participants were stratified into three predefined age groups. Associations between MRI-derived renal biomarkers and age were assessed using Pearson or Spearman correlation, ANOVA, simple and multivariable linear regression analysis.</div></div><div><h3>Results</h3><div>A total of 46 healthy volunteers were included and stratified into three age groups (20–40, 40–60, and 60 + years). T1 medullary (T1 M) relaxation times significantly decreased with age (<em>p</em> &lt; 0.01), accompanied by a reduction in T2* medullary (T2* M) values (<em>p</em> &lt; 0.01) and renal blood flow (RBF) as measured by ASL (<em>p</em> = 0.03). No significant associations were observed between age and IVIM parameters or T2 times. MRI-derived values showed no correlation with serum creatinine in healthy volunteers.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that changes in renal microstructure and function can be quantified using mpMRI, with T1 M and T2* M values as well as RBF emerging as potential imaging biomarkers for renal aging. The ability to assess renal physiology non-invasively using functional MRI may provide a valuable tool for distinguishing physiological renal aging from early pathological deterioration. This approach may enhance early detection of kidney disease and risk stratification in nephrology.</div></div><div><h3>Question</h3><div>Can multiparametric renal MRI non-invasively detect age-related changes in kidney microstructure in healthy adults?</div></div><div><h3>Finding</h3><div>Medullary T1 and T2* values as well as renal blood flow significantly decline with increasing age in healthy volunteers.</div></div><div><h3>Clinical relevance</h3><div>Multiparametric MRI enables early, non-invasive assessment of physiological renal aging and may assist in differentiating early kidney disease from normal aging.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112366"},"PeriodicalIF":3.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Payments from intravascular embolisation device companies to medical professionals and institutions in Japan (2019–2023): An open payment data analysis","authors":"Satoru Yanagaki ,&nbsp;Anju Murayama ,&nbsp;Koyo Kondo ,&nbsp;Tomomi Sato ,&nbsp;Tomonori Matsuura ,&nbsp;Sota Oguro ,&nbsp;Hideki Ota ,&nbsp;Takayuki Yamada ,&nbsp;Kei Takase","doi":"10.1016/j.ejrad.2025.112362","DOIUrl":"10.1016/j.ejrad.2025.112362","url":null,"abstract":"<div><h3>Introduction</h3><div>Financial relationships between medical device companies and medical professionals can lead to inappropriate medical care and generate ethical concerns due to potential conflicts of interest. Monitoring this relationship is paramount to ensure that patients receive optimal and affordable care and that costs for medical services are not unnecessarily increased. In this study, we aimed to characterise the payments reported by each company that manufactures vascular embolisation devices to medical professionals and institutions in Japan and evaluate the system of industry payment disclosure.</div></div><div><h3>Methods</h3><div>This study of industrial payments in the field of intravascular embolisation included a review of disclosed payment data from companies that sell vascular embolisation devices. The payment information reported for the fiscal years 2019–2023 by each company was collected. We evaluated the payment amounts and assessed the data accessibility and quality of industry payment information as secondary outcomes.</div></div><div><h3>Results</h3><div>Eighteen companies that sold intravascular embolisation devices disclosed their payment information and were evaluated in this study. Payments per company were the highest in 2019 ($13.0 million) and the lowest in 2020 ($9.06 million) when the COVID-19 pandemic occurred: however, they have continually increased since then. All companies received low scores for one quality measure and two accessibility measures.</div></div><div><h3>Conclusion</h3><div>The payments from vascular embolisation device industry to medical professionals and institutions increased annually from 2020 to 2023 in Japan. Industry payment disclosures published voluntarily by vascular embolisation device companies showed limitations in both transparency and accessibility, highlighting the need for standardized reporting requirements.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112362"},"PeriodicalIF":3.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological T-staging in prostate Cancer: Towards a universal MRI-based scoring system","authors":"Georgios Agrotis ,&nbsp;Sungmin Woo ,&nbsp;Fredrik Jäderling ,&nbsp;Stephan Ursprung ,&nbsp;Sam J Withey ,&nbsp;Andrei S. Purysko ,&nbsp;Tristan Barrett ,&nbsp;Geert Villeirs ,&nbsp;Ivo G. Schoots","doi":"10.1016/j.ejrad.2025.112363","DOIUrl":"10.1016/j.ejrad.2025.112363","url":null,"abstract":"<div><div>Magnetic resonance imaging (MRI) is recommended for local prostate cancer tumor (T) staging. While MRI offers superior anatomical resolution compared to digital rectal examination, its accuracy in distinguishing organ-confined (T2) from locally advanced (T3a) tumors remains low. This narrative review critically examines the current MRI-based T-staging performance, its limitations, and the clinical implications of image scoring systems to assess local tumor extent. We highlight the evolution from qualitative assessments toward semi-quantitative and quantitative systems, each integrating features like tumor capsular contact length, bulging, capsular irregularity, neurovascular bundle asymmetry, and capsular enhancement. Emerging data suggest that tumor volume and curvilinear capsular contact length exhibit high specificity, however, most features lack sufficient sensitivity and inter-reader agreement to independently guide treatment management. We argue for favoring specificity over sensitivity in MRI-based T-staging, considering that false positive MRI readings carry negative side effects for patients following overtreatment. Finally, we propose the development of a universal MRI-based scoring system tailored to clinical relevance, prioritizing reproducible guidance for treatment decisions over traditional staging accuracy. Such a scoring system better aligns with contemporary therapeutic goals, reduces overtreatment with its negative side effects, and facilitates standardized reporting in clinical trials and practice.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112363"},"PeriodicalIF":3.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Impact of MRI risk assessment on the survival benefits of neoadjuvant chemoradiotherapy in patients with stage II-III rectal cancer: A retrospective cohort study”","authors":"Liya He,&nbsp;Lili Peng,&nbsp;Hongzhen Zhang","doi":"10.1016/j.ejrad.2025.112364","DOIUrl":"10.1016/j.ejrad.2025.112364","url":null,"abstract":"","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"192 ","pages":"Article 112364"},"PeriodicalIF":3.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT in pediatric langerhans cell histiocytosis: relation to BRAFv600e mutation and risk stratification","authors":"Xueli Ji ,&nbsp;Chao Li ,&nbsp;Jinyu Gou ,&nbsp;Xiaodong Wu ,&nbsp;Yafu Yin ,&nbsp;Hongliang Fu ,&nbsp;Hui Wang ,&nbsp;Suyun Chen","doi":"10.1016/j.ejrad.2025.112361","DOIUrl":"10.1016/j.ejrad.2025.112361","url":null,"abstract":"<div><h3>Objective</h3><div>BRAF^V600E correlates with high-risk features and poor response to chemotherapy in pediatric Langerhans cell histiocytosis (LCH). This study aimed to evaluate the role of ¹⁸F-FDG PET/CT in risk stratification and to explore the relationship between ¹⁸F-FDG uptake and BRAF^V600E mutation in LCH.</div></div><div><h3>Methods</h3><div>Pretreatment ¹⁸F-FDG PET/CT scans from 114 newly diagnosed pediatric LCH were retrospectively analyzed. The associations between imaging findings and clinico-pathological parameters were investigated.</div></div><div><h3>Results</h3><div>PET/CT imaging led to a change of disease stratification in 47 (41.2 %) patients. The most common additional organs detected by PET/CT were lymph nodes and thymus. Elevated C-reactive protein (CRP) levels were associated with upstaging [Odds ratio (OR): 2.737, 95 % confidence interval (CI): 1.193–6.276, <em>p</em> = 0.017]. LCH lesions showed significantly higher SUVmax in patients with elevated CRP levels compared to those with normal levels (10.2 ± 4.7 vs. 7.3 ± 3.6, <em>p</em> = 0.001). BRAF^V600E status was tested in 70 patients. Lower ¹⁸F-FDG uptake (SUVmax: 8.2 ± 3.3 vs. 10.8 ± 4.9, <em>p</em> = 0.019) was observed in mutated-BRAF^V600E. Multivariate logistic regression analysis revealed that SUVmax ≤ 10.6 (OR: 6.868, 95 % CI: 1.751–26.946, <em>p</em> = 0.006), absence of thymus involvement (OR: 11.849, 95 %CI: 1.907–73.635, <em>p</em> = 0.008) and CRP ≥ 15.0 mg/L (OR: 8.062, 95 % CI: 1.538–42.263, <em>p</em> = 0.014) significantly correlated with BRAF^V600E mutation.</div></div><div><h3>Conclusions</h3><div>PET/CT identifies extra-osseous diseases in about 40% of patients, especially those with elevated CRP levels. Moreover, ¹⁸F-FDG PET/CT findings were significantly associated with BRAF^V600E mutation status, although wide CIs warrant cautious interpretation.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112361"},"PeriodicalIF":3.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}