European Journal of Radiology最新文献

{"title":"The impact of long axial field of view (LAFOV) PET on oncologic imaging","authors":"Gary J.R. Cook ,&nbsp;Ian L. Alberts ,&nbsp;Thomas Wagner ,&nbsp;B.Malene Fischer ,&nbsp;Muhummad Sohaib Nazir ,&nbsp;David Lilburn","doi":"10.1016/j.ejrad.2024.111873","DOIUrl":"10.1016/j.ejrad.2024.111873","url":null,"abstract":"<div><div>The development of long axial field of view (LAFOV) positron emission tomography coupled with computed tomography (PET/CT) scanners might be considered the biggest step forward in PET imaging since it became a mainstream clinical modality. Despite increased capital and maintenance costs and data storage requirements, the improvement in image quality, significantly faster acquisition times and lower radiopharmaceutical administered activities, allow a high quality and more efficient clinical service. This step change in technology overcomes some of the limitations of standard short axial field of view scanners. It allows simultaneous imaging of all body systems, and with the ability to obtain high temporal resolution data, it increases potential research applications, particularly in multisystem disease or for dosimetry measurements of novel radiopharmaceuticals. The improvements in sensitivity and signal-to-noise facilitates the use of tracers with long half-lives and low administered activity (e.g. [⁸⁹Zr]-labelled monoclonal antibodies) or very short half-lives (e.g. [⁸²Rb]), opening up applications that hitherto have been challenging. It is early in the evolution of LAFOV PET/CT and the advantages these systems offer have still to be fully realised in providing additional impact in clinical practice.</div><div>In this article we describe the potential advantages of LAFOV PET technology and some of the clinical and research applications where it has been applied as well as some of the future developments that may enhance the modality further.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111873"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram incorporating CT-based peri-hematoma radiomics features to predict functional outcome in patients with intracerebral hemorrhage","authors":"Xiaona Xia ,&nbsp;Jieqiong Liu ,&nbsp;Jiufa Cui ,&nbsp;Yi You ,&nbsp;Chencui Huang ,&nbsp;Hui Li ,&nbsp;Daiyong Zhang ,&nbsp;Qingguo Ren ,&nbsp;Qingjun Jiang ,&nbsp;Xiangshui Meng","doi":"10.1016/j.ejrad.2024.111871","DOIUrl":"10.1016/j.ejrad.2024.111871","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the ability of non-contrast computed tomography based <em>peri</em>-hematoma and intra-hematoma radiomic features to predict the 90-day poor functional outcome for spontaneous intracerebral hemorrhage (sICH) and to present an effective clinically relevant machine learning system to assist in prognosis prediction.</div></div><div><h3>Materials and Methods</h3><div>We retrospectively analyzed the data of 691 patients diagnosed with sICH at two medical centers. Fifteen radiomic features from the intra- and <em>peri</em>-hematoma regions were extracted and selected to build six radiomics models. The clinical-semantic model and nomogram model were constructed to compare prediction abilities. The areas under the curve (AUC) and decision curve analysis were used to evaluate discriminative performance.</div></div><div><h3>Results</h3><div>Combining radiomics of the intra-hematoma with <em>peri</em>-hematoma regions significantly improved the AUC to 0.843 compared with radiomics of the intra-hematoma region (AUC = 0.780, <em>P</em> ＜ 0.001) in the test set. A similar trend was observed in the external validation cohort (AUC, 0.769 vs. 0.793, <em>P</em> = 0.709). The nomogram, which integrates clinical-semantic signatures with intra-hematoma and <em>peri</em>-hematoma radiomics signatures, accurately predicted a 90-day poor functional outcome in both the test and external validation sets (AUC 0.879 and 0.901, respectively).</div></div><div><h3>Conclusion</h3><div>The nomogram constructed using clinical-semantic signatures and combined intra-hematoma and <em>peri</em>-hematoma radiomics signatures showed the potential to precisely predict 90-day poor functional outcomes for sICH.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111871"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new thyroid imaging reporting and data system for nodules: Based on grayscale and color Doppler ultrasonography","authors":"Zhu Wang ,&nbsp;Sha-Sha Huang ,&nbsp;Yi-Fan Zhu ,&nbsp;Duo-Duo Hao ,&nbsp;Yi-Zhen Zhang ,&nbsp;Chun-Qiao Chen ,&nbsp;Ying-Wei Wang ,&nbsp;Zhi-Hao Jiang ,&nbsp;Fu-Shun Pan ,&nbsp;Jin-Yu Liang ,&nbsp;Xiao-Yan Xie ,&nbsp;Zheng Yang ,&nbsp;Bin Li ,&nbsp;Hai-Peng Xiao","doi":"10.1016/j.ejrad.2024.111866","DOIUrl":"10.1016/j.ejrad.2024.111866","url":null,"abstract":"<div><h3>Objective</h3><div>To construct and validate a new thyroid imaging reporting and data system (TI-RADS) based on radiating blood flow and grayscale US features.</div></div><div><h3>Materials and methods</h3><div>This study enrolled patients from 4 hospitals from January 2018 to November 2023 retrospectively and prospectively. All US features associated with malignant thyroid nodules were assessed by multivariable logistic regression to construct baseline US TI-RADS (BUS TI-RADS), which was tested with internal validation set, external validation set and prospective validation set. Additionally, its potential of reducing biopsy was assessed.</div></div><div><h3>Results</h3><div>There were 2932 patients (2153 female, age: 42.83 ± 11.71; 779 male, age: 42.36 ± 11.78) with 3940 nodules (2831 malignant nodules and 1109 benign nodules). Independent predictive factors included composition, echogenicity, shape, margin, suspicious extrathyroidal extension, punctate echogenic foci, and radiating blood flow. Compared with American College of Radiology (ACR) TI-RADS and Chinese TI-RADS (C-TIRADS), the BUS TI-RADS had higher AUCs of 0.96 (95 % CI: [0.95, 0.97]; <em>P</em> &lt; 0.001), 0.93 ([0.90, 0.97]; <em>P</em> &lt; 0.001), 0.91 ([0.86, 0.96]; <em>P</em> &lt; 0.003) and 0.95 ([0.93, 0.97]; <em>P</em> &lt; 0.001) for the training set, internal validation set, external validation set and prospective validation set respectively. Decision curve analysis demonstrated higher net benefit for the BUS TI-RADS. And the BUS TI-RADS (4.1 %; 18.1 %) had lower percentage of biopsy and false negative rate compared with the ACR TI-RADS (31.2 %; 20.9 %) and C-TIRADS(33.1 %; 58.5 %).</div></div><div><h3>Conclusion</h3><div>BUS TI-RADS was created according to the simplified regression coefficients of radiating blood flow and grayscale ultrasonography features with excellent diagnostic performance and could reduce unnecessary biopsy with lower missed malignancy.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111866"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Background parenchymal enhancement in CEM and MRI: Is there always a high agreement?","authors":"Francesca Ferrara ,&nbsp;Ambra Santonocito ,&nbsp;William Vogel ,&nbsp;Charlotte Trombadori ,&nbsp;Calogero Zarcaro ,&nbsp;Michael Weber ,&nbsp;Panagiotis Kapetas ,&nbsp;Thomas H. Helbich ,&nbsp;Pascal A.T. Baltzer ,&nbsp;Paola Clauser","doi":"10.1016/j.ejrad.2024.111903","DOIUrl":"10.1016/j.ejrad.2024.111903","url":null,"abstract":"<div><h3>Introduction</h3><div>Background parenchymal enhancement (BPE) refers to the physiological enhancement of breast fibroglandular tissue. This study aimed to determine the agreement of BPE evaluation between contrast enhanced mammography (CEM) and magnetic resonance imaging (MRI) and investigate potential confounders.</div></div><div><h3>Materials and methods</h3><div>This retrospective, IRB-approved study included women recalled from screening or with inconclusive findings on mammography and/or ultrasound, who underwent both CEM and MRI between 2018 and 2022. Imaging protocols followed international recommendations. Two breast radiology fellows assessed density and BPE on CEM and MRI using BI-RADS, evaluating the early post-contrast acquisition (EP). In addition, BPE on MRI was assessed in the late post-contrast acquisition (LP). Data on menopausal status, breast thickness, and compression force were retrieved. Univariate and multivariate analyses were used.</div></div><div><h3>Results</h3><div>343 patients were consecutively enrolled. Post-menopausal patients showed lower BPE levels (p &lt; 0.001). Agreement on BPE levels between CEM and MRI in the EP was fair (R1 κ = 0.342, R2 κ = 0.383). In the LP agreement was moderate for R1 (κ = 0.432) and fair for R2 (κ 0.368). There was a significant correlation between BPE and density in CEM (R1 ρ 0.399, R2 ρ 0.441; p &lt; 0.001). A negative correlation was found on CEM between BPE and compression force (ρ −0.100, p = 0.001). Inter-reader agreement was high with both modalities (CEM κ = 0.678, MRI-EP κ = 0.690, MRI-EP κ = 0.692).</div></div><div><h3>Conclusions</h3><div>The agreement of BPE assessment between MRI and CEM was fair to moderate and reproducibility among readers was high. Compression force and mammographic breast density seem to influence BPE levels in CEM.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111903"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the ethical and regulatory landscape of AI integration in radiology","authors":"Yanxia Jia ,&nbsp;Liang Han ,&nbsp;Yilong Dai ,&nbsp;Chengqiang Jin","doi":"10.1016/j.ejrad.2024.111910","DOIUrl":"10.1016/j.ejrad.2024.111910","url":null,"abstract":"","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111910"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritherapeutic intra-arterial flow changes predict long-term stent patency in patients with severe intracranial artery stenosis receiving PTAS","authors":"Feng-Chi Chang ,&nbsp;Chia-Jen Wu ,&nbsp;Kan Ling ,&nbsp;Ting-Yi Chen ,&nbsp;Jiing-Feng Lirng ,&nbsp;Chia-Hung Wu","doi":"10.1016/j.ejrad.2024.111913","DOIUrl":"10.1016/j.ejrad.2024.111913","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The quantitative intra-arterial flow dynamics following percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial artery stenosis have never been investigated. We aimed to evaluate peritherapeutic intracranial artery flow dynamics following PTAS with quantitative magnetic resonance angiography (qMRA) to predict long-term stent patency.</div></div><div><h3>Design</h3><div>This is a prospective, single-center study.</div></div><div><h3>Methods</h3><div>We recruited participants with severe symptomatic stenosis from intracranial internal carotid artery (ICA) to M1 segment of middle cerebral artery (MCA) between 2018 and 2022. qMRA was performed before (preprocedural), within 24 h after (early postprocedural) and 12 months after (delayed postprocedural) PTAS, and parameters including bilateral M1 segments and basilar artery (BA) flow were recorded. The calibrated M1 ratio was calculated using contralateral M1 (cM1) and BA (cMB) flows as references. We assessed differences in qMRA parameters between subjects with and without significant 12-month in-stent restenosis (ISR).</div></div><div><h3>Results</h3><div>Forty-four subjects (12 with + 32 without ISR ≥ 50 %) were included. The early postprocedural M1 flow was higher than preprocedural M1 flow in subjects with (<em>p</em> = 0.030) and without (<em>p</em> = 0.031) ISR. The early postprocedural healthy-side M1 flow was lower than preprocedural healthy-side M1 flow (<em>p</em> = 0.014) in subjects without ISR. Both the early (<em>p</em> &lt; 0.001) and delayed (<em>p</em> = 0.014) cM1s were greater than the preprocedural cM1. The residual stenosis grade was positively correlated with delayed postprocedural cM1 in all subjects (r² = 0.190; <em>p</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>The cM1 and a distinct flow dynamic pattern on early qMRA (within 24 h after PTAS) may predict 12-month ISR.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111913"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery calcification severity in long term breast cancer survivors treated with isolated contemporary radiotherapy: Relation to dose and CV risk factors","authors":"Pauline Krug ,&nbsp;Xavier Geets ,&nbsp;Martine Berlière ,&nbsp;François Duhoux ,&nbsp;Christophe Beauloye ,&nbsp;Agnès Pasquet ,&nbsp;David Vancraeynest ,&nbsp;Anne-Catherine Pouleur ,&nbsp;Bernhard L. Gerber ,&nbsp;FESC FACC FAHA","doi":"10.1016/j.ejrad.2024.111909","DOIUrl":"10.1016/j.ejrad.2024.111909","url":null,"abstract":"<div><h3>Background</h3><div>Ancillary breast cancer (BC) radiation therapy (RT), particularly associated with chemotherapy, increases the risk of coronary artery disease (CAD). However, it remains unclear whether this risk also applies to isolated contemporary radiotherapy without chemotherapy.</div></div><div><h3>Methods</h3><div>Seventy-five BC patients (35 left-sided and 40 right-sided) treated with RT and available dosimetry, prospectively underwent Agatston calcium score (CAC) and coronary CT angiography (CTCA) a median of 11 ± 1 years later and were compared to 75 age- and cardiovascular (CV) risk factor-matched female controls without a history of cancer.</div></div><div><h3>Results</h3><div>BC patients and controls had similar ages (62 ± 7 vs. 61 ± 7 years, p = 0.63), CV risk factors and estimated Score2/OP risk (3.8 % IQR 2.6–6 vs. 3.3 % IQR 2.3–5.4, p = 0.52). CAC scores (0 IQR 0–79 vs. 0 IQR 0–34, p = 0.62) and age-predicted percentile CAC scores (p = 0.61) were similar between BC patients and controls, with no significant difference between left- and right-sided RT. Multivariable analysis revealed that CAC scores in BC patients were predicted only by a family history of CAD and by Score-2/OP risk, but not by cardiac radiation exposure. By CTCA 68 % of BC patients had no or very mild coronary disease, and only 14 % had more than moderate stenosis (&gt;50 %), which was predicted by CAC scores &gt; 79 (AUC = 0.97).</div></div><div><h3>Conclusion</h3><div>Eleven years post-treatment with isolated contemporary RT for BC, patients exhibited similar CAC severity as age- and risk factor-matched controls. CAC was associated only with CV risk factors, but not radiation dose, suggesting contemporary RT for BC is not linked to higher subclinical CAD prevalence.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111909"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing joy of reading and the impact of scientific articles– the benefits of RadioComics","authors":"Isabel Molwitz ,&nbsp;Ingrid Boehm","doi":"10.1016/j.ejrad.2024.111862","DOIUrl":"10.1016/j.ejrad.2024.111862","url":null,"abstract":"","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111862"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast-enhanced pseudo-CT of finger joints: Improved diagnostic confidence for detection of inflammatory erosions","authors":"Christoph Stern ,&nbsp;Georg C. Feuerriegel ,&nbsp;Christoph Germann ,&nbsp;Stefan Sommer ,&nbsp;Daniel Nanz ,&nbsp;Reto Sutter","doi":"10.1016/j.ejrad.2024.111856","DOIUrl":"10.1016/j.ejrad.2024.111856","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the interest of additional pseudo-CT images to standard clinical contrast-enhanced MR images (CE-MRI) in the detection of inflammatory erosions and to differentiate them from intraosseous ganglia at the finger joints.</div></div><div><h3>Method</h3><div>47 prospectively included patients with suspected or diagnosed rheumatoid arthritis received a CE-MRI of the fingers. Additionally, pseudo-CT images were derived from non-contrast MRI (pCT) and from contrast-enhanced MRI data (CE-pCT) using a high-resolution gradient-echo 3D fast low-angle shot sequence (FLASH), respectively. CE-MRI, pCT, and CE-pCT images were evaluated for erosions and intraosseous ganglia at the metacarpophalangeal and proximal interphalangeal joints by two musculoskeletal radiologists. Findings were defined on CE-MRI by an experienced independent 3rd reader which served as reference standard. Diagnostic confidence (1 = worst, 4 = best) was rated for 3 different image sets (1 = CE-MRI, 2 = CE-MRI + pCT, 3 = CE-MRI + CE-pCT) and compared.</div></div><div><h3>Results</h3><div>Reference standard revealed 44 erosions and 37 intraosseous ganglia on CE-MRI. Diagnostic confidence for CE-MRI was moderate for erosions (both readers) and intraosseous ganglia (reader 2). For the combination of CE-MRI and pCT, high confidence levels were observed for erosions for both readers (median 3 (Q1–Q3: 2.5–3) and 3 (3–3); <em>p&lt;</em>.001 and <em>p&lt;</em>.001) and for intraosseous ganglia for reader 2 (3 (3–3); <em>p&lt;</em>.001). CE-MRI combined with CE-pCT showed very high confidence levels for both readers for erosions (4 (3–4) and 4 (4–4); <em>p&lt;</em>.001 and <em>p&lt;</em>.001) and for intraosseous ganglia (4 (4–4) and 4 (4–4); <em>p&lt;</em>.001 and <em>p&lt;</em>.001).</div></div><div><h3>Conclusions</h3><div>Pseudo-CT combined with CE-MRI increases the confidence in detection of inflammatory erosions at the finger joints, with CE-pCT being superior to pCT.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111856"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT perfusion and MRI: A combined approach for hepatocellular carcinoma diagnosis and follow-up after locoregional treatment","authors":"Georgios Kalarakis ,&nbsp;Evangelia G. Chryssou ,&nbsp;Kostas Perisinakis ,&nbsp;Michail E. Klontzas ,&nbsp;Dimitrios Samonakis ,&nbsp;Adam Hatzidakis","doi":"10.1016/j.ejrad.2025.111928","DOIUrl":"10.1016/j.ejrad.2025.111928","url":null,"abstract":"<div><h3>Objective</h3><div>CT liver perfusion (CTLP) has been well validated for hepatocellular carcinoma (HCC) detection, characterization, and treatment response evaluation. However, its role in HCC management algorithms remains unclear. This study aims to assess the diagnostic performance of CTLP alone or as an adjunct to MRI in patients considered for- or undergoing locoregional treatment for HCC.</div></div><div><h3>Material and Methods</h3><div>Thirty-nine patients under HCC surveillance (36 male, 31 cirrhotic, 16 pretreatment, 19 post-transarterial chemoembolization, 2 post-ablation) underwent MRI and CTLP in a single center within a 45-day interval. Two readers identified and characterized all observations on MRI using Liver Imaging Reporting and Data System (LI-RADS) v2018 criteria. CTLP assessment was based on Mean Slope of Increase (MSI), Time To Peak (TTP), Hepatic arterial Blood Flow (HaBF) and Hepatic Arterial Fraction (HAF) maps and established cut-offs. Diagnostic performance of MRI, CTLP, and their combination was evaluated for treated and untreated lesions using imaging or pathology as reference standard.</div></div><div><h3>Results</h3><div>Of the total 33 treated and 61 untreated lesions, 13 and 41 were considered viable HCCs. CTLP demonstrated 75.9 % sensitivity and 95 % specificity compared to 72.2 % and 100 % for MRI (p &gt; 0.05). Combining both modalities increased sensitivity to 85.2 % (p &lt; 0.05) and maintained specificity at 97.5 % (p &gt; 0.05). The combined approach led to an LR category change in 5 treated and 19 untreated lesions and affected management in 5 cases.</div></div><div><h3>Conclusion</h3><div>CTLP and MRI have comparable diagnostic performance for HCC. A combined approach improves sensitivity, without sacrificing specificity. This approach might enable more efficient patient selection for early and individualized loco-regional treatment.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"183 ","pages":"Article 111928"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}