European Journal of Radiology最新文献

{"title":"Cost-effectiveness of [18F]FDG PET/CT in follow-up after thermal ablation in patients with colorectal liver metastases in the Dutch healthcare setting","authors":"S. van Mossel ,&nbsp;O.D. Bijlstra ,&nbsp;F.A. van Delft ,&nbsp;B. Boekestijn ,&nbsp;M.C. Burgmans ,&nbsp;P. Hendriks ,&nbsp;E. Kapiteijn ,&nbsp;J.S.D. Mieog ,&nbsp;E.L. van Persijn van Meerten ,&nbsp;D.D.D. Rietbergen ,&nbsp;S.Shahbazi Feshtali ,&nbsp;R.J. Swijnenburg ,&nbsp;L.F. de Geus-Oei ,&nbsp;H. Koffijberg","doi":"10.1016/j.ejrad.2025.112277","DOIUrl":"10.1016/j.ejrad.2025.112277","url":null,"abstract":"<div><h3>Introduction</h3><div>The ESMO and ECIO-ESOI consensus guidelines vary in their recommendations regarding the use of ¹⁸F-Fluorodeoxyglucose ([¹⁸F]FDG) PET/CT in the follow-up after thermal ablation in patients with colorectal liver metastases. This is partly because studies providing data on long-term benefits of [¹⁸F]FDG PET/CT are lacking. Therefore, a simulation model was developed to examine how follow-up with [¹⁸F]FDG PET/CT impacts treatment planning, health and cost outcomes.</div></div><div><h3>Methods</h3><div>For an illustrative Dutch cohort, lifetime health and cost outcomes were simulated to assess the cost-effectiveness of performing a single additional [¹⁸F]FDG PET/CT. Patients followed a standard surveillance schedule consisting of three-monthly serum CEA and contrast-enhanced CT, plus [¹⁸F]FDG PET/CT 3–4 months after thermal ablation. Therapy could be repeated downstream the care pathway. Quality-of-life and survival estimates were based on disease stage and age. Costs were determined from a healthcare perspective incorporating costs related to diagnostics and treatments. The Consolidated Health Economic Evaluation Reporting Standards were followed.</div></div><div><h3>Results</h3><div>Health benefits of additional [¹⁸F]FDG PET/CT were negligible, incremental QALYs &lt; 0.001, whereas costs increased by €1,277, mainly due to the additional imaging. This lack of health benefits can be explained by the small subset of simulated patients (&lt;5 %) in whom [¹⁸F]FDG PET/CT affected treatment planning.</div></div><div><h3>Discussion</h3><div>Additional [¹⁸F]FDG PET/CT 3–4 months after thermal ablation is unlikely to be cost-effective. More research is needed to determine if using [¹⁸F]FDG PET/CT in subgroups of patients, or at alternative time points, is cost-effective. This requires collecting more (extensive) follow-up data across multiple centres to reflect heterogeneity between hospitals’ clinical practices.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112277"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between mesorectal adipose tissue volume measured by computed tomography and histopathological prognostic features in patients with rectal cancer","authors":"Esra Temel ,&nbsp;Mustafa Kaya ,&nbsp;Leyla Mirzayeva","doi":"10.1016/j.ejrad.2025.112261","DOIUrl":"10.1016/j.ejrad.2025.112261","url":null,"abstract":"<div><h3>Purpose</h3><div>The objective of this study was to examine the correlation between visceral adipose tissue (VAT) and mesorectal adipose tissue (MAT) volumes and poor prognostic factors, including extramural venous invasion (EMVI) and perirectal fat invasion (PFI).</div></div><div><h3>Methods</h3><div>All patients with rectal cancer who had undergone abdominopelvic computed tomography (CT) from January 2015 to December 2023 were reviewed retrospectively. The quantitative measurement of the MAT and VAT volumes was conducted by two radiologists utilising CT based softwear programme. The measurements were compared with histopathologic parameters such as extramural venous invasion and perirectal fat invasion on pelvic magnetic resonance imaging (MRI).</div></div><div><h3>Results</h3><div>A total of 148 patients were included in the study (58F, 90 M). The mean age of the patients was 59.45 ± 9.97 years. The mean values of both MAT and VAT volumes were found to be significantly higher in patients with positive EMVI than in those with negative EMVI (p &lt; 0,05). Furthermore, the mean values of both MAT and VAT volumes were found to be significantly higher in patients with positive perirectal fat invasion (p &lt; 0.05). Patients with positive EMVI and PFI also had a significantly higher body mass index (BMI) (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>It may be the case that the volume of MAT and VAT are useful in predicting the prognosis of rectal cancer.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112261"},"PeriodicalIF":3.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic prostate volume estimation in transabdominal ultrasound images","authors":"Tiziano Natali ,&nbsp;Liza M. Kurucz ,&nbsp;Matteo Fusaglia ,&nbsp;Laura S. Mertens ,&nbsp;Theo J.M. Ruers ,&nbsp;Pim J. van Leeuwen ,&nbsp;Behdad Dashtbozorg","doi":"10.1016/j.ejrad.2025.112274","DOIUrl":"10.1016/j.ejrad.2025.112274","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer is a major health concern requiring accurate and accessible methods for early detection and risk stratification. Prostate volume (PV) is a key parameter in multivariate risk assessment, traditionally measured using transrectal ultrasound (TRUS). While TRUS provides precise measurements, its invasive nature affects patient comfort. Transabdominal ultrasound (TAUS) offers a non-invasive alternative but is limited by lower image quality and operator dependence. This study presents a deep-learning-based framework for automatic PV estimation using TAUS, aiming to improve non-invasive prostate cancer risk stratification.</div></div><div><h3>Methods</h3><div>A dataset of TAUS videos from 100 patients (median age 67, 95-percentile range 55–81.2) was curated, with expert-delineated prostate boundaries and diameter calculations as ground truth. The framework integrates deep-learning models for prostate segmentation in both axial and sagittal planes, automatic diameter estimation, and PV calculation. Segmentation performance was evaluated using Dice correlation coefficient (%) and Hausdorff distance (mm), while volume estimation accuracy was assessed through volumetric error (mL).</div></div><div><h3>Results</h3><div>The axial model outperformed the sagittal model, achieving a Dice score of 0.76 ± 0.16 versus 0.68 ± 0.21, a Dice-MidPlane of 0.91 ± 0.06 versus 0.83.</div><div>± 0.10, and a Hausdorff distance of 6.21 ± 4.33 mm versus 7.93 ± 4.27 mm. The framework estimated PV with a mean volumetric error of −2.1 mL (95 % limits of agreement: −16.9 to 21.1 mL), resulting in a relative error smaller than 25 %.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential of deep learning for accurate, non-invasive PV estimation, supporting improved prostate cancer risk assessment.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112274"},"PeriodicalIF":3.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast-enhanced CT-Derived extracellular volume fraction predicts survival in postoperative pancreatic cancer patients","authors":"Shuai Ming ,&nbsp;Wuyang Zhang ,&nbsp;Min Wang ,&nbsp;Jingyu Li ,&nbsp;Dan Shi ,&nbsp;Bin Wang ,&nbsp;Mengru Li ,&nbsp;Yadi Zhang ,&nbsp;Chenglin Zhu ,&nbsp;Aiyun Sun ,&nbsp;Wei Wei","doi":"10.1016/j.ejrad.2025.112273","DOIUrl":"10.1016/j.ejrad.2025.112273","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the prognostic value of extracellular volume (ECV) fraction derived from contrast-enhanced computed tomography (CECT) in predicting survival outcomes of resectable pancreatic ductal adenocarcinoma (PDAC).</div></div><div><h3>Methods</h3><div>The study cohort included a total of 166 patients with resectable PDAC who underwent CECT before operative excision between Jan 2018 and Mar 2021. Tumor CT-derived ECV fractions were calculated from unenhanced and equilibrium-phase CT images. The effects of clinical factors, CECT parameters, and tumor CT-derived ECV fractions on overall survival (OS) and progression-free survival (PFS) were assessed by univariate and multivariate analyses using Cox proportional hazards models. In order to verify the reliability of ECV, Masson’s Trichrome staining was performed on surgical resection specimens from a subset of patients to quantify intratumoral collagen content. Pearson correlation analyzed relationships between CT-derived ECV and collagen ratio (CR).</div></div><div><h3>Results</h3><div>The median value of CT-derived ECV fraction was 32 % (21 % − 41 %) . Increasing tumor CT-derived ECV fractions were associated with a positive effect on OS and PFS. Age and CT-derived ECV fraction was an independent predictor of OS (p = 0.012; p = 0.001) in patients with postoperative PDAC. Tumor size and CT-derived ECV fraction was an independent predictor of PFS (p = 0.016; p = 0.001) in patients with postoperative PDAC. ECV strongly correlated with CR (R² = 0.860, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>CT-derived ECV fraction is a noninvasive biomarker for predicting survival in resectable PDAC.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112273"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]-FAPI-04 PET/CT improves metastatic lesions detection for patients with uterine malignancy after radical surgery: prospectively compared with [18F]-FDG PET/CT","authors":"Haipeng Chen ,&nbsp;Hao Peng ,&nbsp;Jiucen Liang ,&nbsp;Shuqin Jiang ,&nbsp;Shuyi Li ,&nbsp;Zhidong Liu ,&nbsp;Jingjing Song ,&nbsp;Yuanlin Chen ,&nbsp;Yan Hao ,&nbsp;Linqi Zhang ,&nbsp;Rusen Zhang","doi":"10.1016/j.ejrad.2025.112270","DOIUrl":"10.1016/j.ejrad.2025.112270","url":null,"abstract":"<div><h3>Objectives</h3><div>This prospective study aimed to investigate the potential of [¹⁸F]-fibroblast activation protein inhibitor ([¹⁸F]-FAPI)-04 PET/CT for evaluating suspected recurrent uterine malignancy after radical surgery, and prospectively compared it with [¹⁸F]-Fluorodeoxyglucose ([¹⁸F]-FDG) PET/CT.</div></div><div><h3>Methods</h3><div>From August 2022 to August 2024, patients with suspected recurrent/metastatic uterine malignancy following radical surgery received both [¹⁸F]-FDG PET/CT and [¹⁸F]-FAPI-04 PET/CT examinations, with imaging data prospectively evaluated. The comparative diagnostic efficacy of two PET/CT modalities for recurrence detection was statistically assessed using McNemar’s test and the difference of lesion tracer uptake parameters [Maximum standardized uptake value (SUV_max) and Tumor-to-Background Ratio (TBR)] were analyzed by Wilcoxon signed-rank tests.</div></div><div><h3>Results</h3><div>36 patients with 482 local relapses and distant metastases were included. Local relapses demonstrated comparable diagnostic performance between [¹⁸F]-FAPI-04 and [¹⁸F]-FDG PET/CT, with no significant differences in SUV_max and TBR. In nodal metastases assessment, [¹⁸F]-FAPI-04 PET/CT exhibited superior detection capability over [¹⁸F]-FDG PET/CT (p &lt; 0.01), with the diagnostic advantage most evident in abdominal lymph node metastases. Visceral metastatic lesions demonstrated significantly elevated [¹⁸F]-FAPI-04 PET/CT uptake parameters (SUV_max and TBR) compared to [¹⁸F]-FDG PET/CT imaging, especially in peritoneal and brain metastases.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]-FAPI-04 PET/CT demonstrated superior detection capability for postoperative metastatic lesions in uterine cancer patients compared to [¹⁸F]-FDG PET/CT, with particularly diagnostic advantage in abdominal lymph node, brain, and peritoneal metastases.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112270"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of bioresorbable gelatin microspheres for organ-preserving transarterial embolization in arterial bleeding","authors":"Jae Hwan Lee ,&nbsp;Chong-ho Lee ,&nbsp;Kun Yung Kim ,&nbsp;Young-Min Han ,&nbsp;Minuk Kim ,&nbsp;Sung-hwan Yoon ,&nbsp;Chang Jin Yoon","doi":"10.1016/j.ejrad.2025.112269","DOIUrl":"10.1016/j.ejrad.2025.112269","url":null,"abstract":"<div><h3>Purpose</h3><div>Bioresorbable gelatin microspheres (R-GMs) allow controlled and temporary embolic effects with adjustable degradation times. This study aimed to assess the feasibility and safety of R-GMs for temporary embolization in a porcine kidney model of arterial bleeding.</div></div><div><h3>Methods</h3><div>The pigs were randomly assigned to the R-GM group or conventional gelatin microsphere (C-GM) group. Active bleeding was induced in ten male pigs by perpendicular puncturing the lower polar artery of the right kidney under ultrasound guidance. Immediate angiography confirmed arterial bleeding. Proximal embolization of the lower polar artery was performed in each group. Follow-up angiography to monitor embolization status, re-bleeding, and recanalization, with the follow-up time points assessing both the short- and long-term re-bleeding risk. On day 7, the pigs were sacrificed, and a histopathologic examination was performed to evaluate residual embolic material, inflammatory response, and tissue damage within the embolized lower polar area.</div></div><div><h3>Results</h3><div>None of the animals showed re-bleeding. In the R-GM group, perfusion surrounding the injured vessel was restored as early as at 2 post-intervention hours, while the lower polar artery remained occluded in the C-GM group until day 7. Further, the R-GM group had a smaller infarct area in the lower pole of the right kidney than the C-GM group (5.80 ± 9.46 % vs. 93.32 ± 13.21 %, p &lt; 0.001), with markedly lower levels of inflammatory cell infiltration and fibrosis.</div></div><div><h3>Conclusion</h3><div>Temporary embolization with R-GMs effectively achieved hemostasis and allowed controlled recanalization, which minimized collateral tissue damage. These findings support the feasibility of R-GMs for organ-preserving embolization in acute arterial bleeding.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112269"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of imaging-guided biopsy for hepatocellular carcinoma","authors":"Roberto Cannella ,&nbsp;Zachary T. Berman ,&nbsp;Nikhil V. Tirukkovalur ,&nbsp;Samer T. Tohme ,&nbsp;Marta I. Minervini ,&nbsp;Alessandro Furlan","doi":"10.1016/j.ejrad.2025.112271","DOIUrl":"10.1016/j.ejrad.2025.112271","url":null,"abstract":"<div><div>Percutaneous imaging-guided biopsy of hepatocellular carcinoma (HCC) is a relatively safe procedure with an established diagnostic role, and a growing value in providing prognostic and treatment information for patient’s management. Because of the high specificity and positive predictive value of tumoral features on cross-sectional imaging studies, the number of biopsies performed for HCC is limited to certain specific clinical scenarios. However, routine imaging fails to fully capture the tumor’s molecular heterogeneity, and as research unravels the potential of tumoral histopathological and molecular stratification, biopsy is poised to transition from a diagnostic tool to a powerful prognostication instrument, contributing to guiding personalized treatment management for patients with HCC. In this review paper, we explore the role of percutaneous, imaging-guided biopsy in the diagnosis, prognosis, and treatment of HCC.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112271"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Stop multienergy pancreatic dynamic volume perfusion imaging using photon-counting detector CT: Initial experience","authors":"Yanzhao Yang ,&nbsp;Naiyi Zhu ,&nbsp;Huimin Lin ,&nbsp;Zhihan Xu ,&nbsp;Rui Chang ,&nbsp;Weimin Chai ,&nbsp;Fuhua Yan","doi":"10.1016/j.ejrad.2025.112268","DOIUrl":"10.1016/j.ejrad.2025.112268","url":null,"abstract":"<div><h3>Purpose</h3><div>This study reports initial experience with a modified one-stop, multienergy pancreatic VPCT protocol using PCCT, designed for comprehensive morphologic analysis and functional perfusion assessment of pancreatic ductal adenocarcinoma (PDAC).</div></div><div><h3>Materials and Methods</h3><div>From April 2024 to October 2024, participants with suspected PDAC were prospectively enrolled and underwent preoperative pancreatic dynamic VPCT. Individual phase images were extracted from perfusion datasets using T3D, virtual monoenergetic images (VMIs) at 55 and 70 keV reconstruction for diagnostic interpretation. Diagnostic image quality was assessed both quantitatively and subjectively. Perfusion maps were generated for analysis. Perfusion parameters were compared between PDAC lesions and normal parenchyma, as well as among PDAC histopathological differentiation. Radiation doses were recorded.</div></div><div><h3>Results</h3><div>A total of 65 participants (39 male; mean age, 66.2 ± 6.3 years) with histologically confirmed PDAC were included. The protocol achieved a mean effective radiation dose of 16.4 ± 4.5 mSv. All individual phase images met diagnostic quality standards (subjective scores ≥ 3). Among these, 55 keV VMIs demonstrated the highest CNR for PDAC lesions and adjacent vasculature, and superior subjective scores for lesion conspicuity in both pancreatic parenchymal and portal venous phases (all p &lt; 0.05). Perfusion parameters, including blood flow (BF), blood volume (BV), time to drain (TTD), mean transit time, time to start, Tmax, and flow extraction product (FEP), differed significantly between PDAC lesions and normal parenchyma (all p &lt; 0.05). Poorly differentiated PDAC lesions exhibited significantly lower BF, BV, TTD, and Tmax values and reduced lesion-to-parenchyma ratios of BF, BV, and FEP compared to moderately-to-well-differentiated PDAC lesions.</div></div><div><h3>Conclusion</h3><div>The one-stop, multienergy pancreatic VPCT protocol using PCCT enables high-quality morphologic imaging and reliable functional perfusion assessment at reduced radiation doses. It provides valuable insights into PDAC differentiation and histopathological grading, with potential implications for improved clinical management.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112268"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging features of mesonephric-like adenocarcinoma of the uterine corpus in comparison with endometrial endometrioid carcinoma: Multi-institutional study","authors":"Saki Yamamoto ,&nbsp;Mitsuru Matsuki ,&nbsp;Sota Masuoka ,&nbsp;Tomohiro Kikuchi ,&nbsp;Hiroyuki Fujii ,&nbsp;Atsushi Kihara ,&nbsp;Naoki Sano ,&nbsp;Noriyoshi Fukushima ,&nbsp;Hiroyuki Fujiwara ,&nbsp;Hiroki Kato ,&nbsp;Yuki Himoto ,&nbsp;Hideyuki Fukui ,&nbsp;Takahiro Tsuboyama ,&nbsp;Yoshiko Ueno ,&nbsp;Shinya Fujii ,&nbsp;Kaori Yamada ,&nbsp;Harushi Mori","doi":"10.1016/j.ejrad.2025.112260","DOIUrl":"10.1016/j.ejrad.2025.112260","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine magnetic resonance imaging (MRI) features of mesonephric-like adenocarcinoma (MLA) of the uterine corpus.</div></div><div><h3>Method</h3><div>MRI features of 19 patients with pathologically proven MLA of the uterine corpus were retrospectively compared with those of 95 patients with endometrial endometrioid carcinoma (EEC).</div></div><div><h3>Results</h3><div>Most patients with MLA were postmenopausal. Advanced FIGO stages were more common in the MLA than in the EEC group (63.2 % vs. 18.9 %, <em>p</em> &lt; 0.001). On MRI, endophytic growth into the myometrium were more frequent in the MLA than in the EEC group (68.4 % vs. 14.7 %, <em>p</em> = 0.005). The median maximum tumor diameter in the MLA group (52.4 mm) tended to be larger than that in the EEC group (38.9 mm), although the difference was not statistically significant (<em>p</em> = 0.374). The tumor-to-muscle signal intensity ratio (SIR) on fat-suppressed gadolinium-enhanced T1-weighted gradient-echo imaging was higher in the MLA group than in the EEC group. (1.67 vs. 1.36, <em>p</em> = 0.002). The SIR on diffusion-weighted imaging (DWI) was comparable between the two groups (8.35 vs. 6.72, <em>p</em> = 0.330). The apparent diffusion coefficient value was lower in the MLA than in the EEC group (0.69 10^-3 mm²/s vs. 0.76 × 10^-3 mm²/s, <em>p</em> = 0.003). Coexisting adenomyosis was more frequent in the MLA than in the EEC group (52.6 % vs. 21.1 %, <em>p</em> = 0.034). The concordance rate between MRI and pathology for adenomyosis coexistence was 84.2 % for MLA, 87.4 % for EEC, and 86.8 % overall. MLA of the uterine corpus was identified in two patients, characterized by development independent of and discontinuous from the endometrium, whereas EEC in all patients demonstrated continuity with the endometrium.</div></div><div><h3>Conclusions</h3><div>MRI of MLA of the uterine corpus typically demonstrates large, diffuse, and endophytic growth into the myometrium, with strong contrast enhancement and more restricted diffusion compared to EEC, with coexisting adenomyosis present in over 50% of patients. Therefore, postmenopausal women with adenomyosis should be carefully evaluated for MLA on MRI, particularly using DWI.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112260"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable classification of Parkinson’s disease with different motor subtypes by analyzing the synthetic MRI quantitative parameters of subcortical nuclei","authors":"Dongliang Cheng ,&nbsp;Junyan Wen ,&nbsp;Yulin Liu ,&nbsp;Nan Ding ,&nbsp;Zhenpeng Duan ,&nbsp;Yunjun Yang ,&nbsp;Yaozhong Wu ,&nbsp;Hang Wang ,&nbsp;Jincheng Ma ,&nbsp;Jialu Zhang ,&nbsp;Zhifeng Xu ,&nbsp;Hai Zhao ,&nbsp;Ge Wen","doi":"10.1016/j.ejrad.2025.112272","DOIUrl":"10.1016/j.ejrad.2025.112272","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore differences in quantitative parameters of subcortical nuclei using synthetic MRI across different motor subtypes of Parkinson’s Disease (PD), and to develop an interpretable model for distinguishing PD subtypes.</div></div><div><h3>Methods</h3><div>A total of 102 PD patients, including 43 Tremor-Dominant (TD) subtype and 59 Postural Instability and Gait Difficulty (PIGD) subtype and 42 age- and gender-matched healthy controls (HCs) were included. T1, T2, Proton Density (PrD), and Myelin Content (MYC) were extracted from 16 subcortical nuclei. We used Least Absolute Shrinkage and Selection Operator (LASSO) regression to select features for Support Vector Machine (SVM) classification models and construct three classification models using one-vs-one strategy. Shapley analysis (SHAP) was used to explain the model.</div></div><div><h3>Results</h3><div>The PIGD subtype exhibited more extensive changes in SyMRI parameters in basal ganglia nuclei than the TD subtype, particularly in T1 and T2. AUC values in the training and validation sets were as follows: 0.897/0.818 (PIGD vs. HC), 0.847/0.787 (TD vs. HC), and 0.820/0.769 (PIGD vs. TD). SHAP analysis revealed that in the PIGD vs. HC comparison, the top three features were T2_R_putamen (positive association) and MYC_L_GPi and MYC_R_SN (both negatively associated). In the TD vs. HC comparison, the top three features were T2_R_putamen, T1_R_SN, and T1_L_STN (all positively associated). In the PIGD vs. TD comparison, PrD_R_GPe and T2_R_SN were positively correlated, while MYC_L_GPi and MYC_R_GPe were negatively correlated.</div></div><div><h3>Conclusion</h3><div>SyMRI effectively detect brain microdamage in PD and distinguish between motor subtypes. Additionally, SHAP analysis identifies key predictive features for distinguishing these subtypes.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"190 ","pages":"Article 112272"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}