European Journal of Radiology最新文献

{"title":"Impact of super-resolution deep learning-based reconstruction for hippocampal MRI: A volunteer and phantom study","authors":"Sentaro Takada ,&nbsp;Takeshi Nakaura ,&nbsp;Naofumi Yoshida ,&nbsp;Hiroyuki Uetani ,&nbsp;Kaori Shiraishi ,&nbsp;Naoki Kobayashi ,&nbsp;Kensei Matsuo ,&nbsp;Kosuke Morita ,&nbsp;Yasunori Nagayama ,&nbsp;Masafumi Kidoh ,&nbsp;Yuichi Yamashita ,&nbsp;Ryohei Takayanagi ,&nbsp;Toshinori Hirai","doi":"10.1016/j.ejrad.2025.112289","DOIUrl":"10.1016/j.ejrad.2025.112289","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>To evaluate the effects of super-resolution deep learning-based reconstruction (SR-DLR) on thin-slice T2-weighted hippocampal MR image quality using 3 T MRI, in both human volunteers and phantoms.</div></div><div><h3>Materials and Methods</h3><div>Thirteen healthy volunteers underwent hippocampal MRI at standard and high resolutions. Original (standard-resolution; StR) images were reconstructed with and without deep learning-based reconstruction (DLR) (Matrix = 320 × 320), and with SR-DLR (Matrix = 960 × 960). High-resolution (HR) images were also reconstructed with/without DLR (Matrix = 960 × 960). Contrast, contrast-to-noise ratio (CNR), and septum slope were analyzed. Two radiologists evaluated the images for noise, contrast, artifacts, sharpness, and overall quality. Quantitative and qualitative results are reported as medians and interquartile ranges (IQR). Comparisons used the Wilcoxon signed-rank test with Holm correction. We also scanned an American College of Radiology (ACR) phantom to evaluate the ability of our SR-DLR approach to reduce artifacts induced by zero-padding interpolation (ZIP).</div></div><div><h3>Results</h3><div>SR-DLR exhibited contrast comparable to original images and significantly higher than HR-images. Its slope was comparable to that of HR images but was significantly steeper than that of StR images (p &lt; 0.01). Furthermore, the CNR of SR-DLR (10.53; IQR: 10.08, 11.69) was significantly superior to the StR-images without DLR (7.5; IQR: 6.4, 8.37), StR-images with DLR (8.73; IQR: 7.68, 9.0), HR-images without DLR (2.24; IQR: 1.43, 2.38), and HR-images with DLR (4.84; IQR: 2.99, 5.43) (p &lt; 0.05). In the phantom study, artifacts induced by ZIP were scarcely observed when using SR-DLR.</div></div><div><h3>Conclusion</h3><div>SR-DLR for hippocampal MRI potentially improves image quality beyond that of actual HR-images while reducing acquisition time.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112289"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective comparison of brain tumor detection and characterization using post-contrast Dixon uT1RESS and MPRAGE at 3 Tesla","authors":"Adrienn Tóth ,&nbsp;Robert R. Edelman ,&nbsp;Muhammad Taha Hagar ,&nbsp;Dmitrij Kravchenko ,&nbsp;Milán Vecsey-Nagy ,&nbsp;James Ira Griggers ,&nbsp;Jonathan Eernisse ,&nbsp;Tilman Emrich ,&nbsp;M. Vittoria Spampinato ,&nbsp;Akos Varga-Szemes","doi":"10.1016/j.ejrad.2025.112283","DOIUrl":"10.1016/j.ejrad.2025.112283","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to evaluate the image quality and lesion characterization with Dixon unbalanced T1 relaxation-enahnced steady-state (uT1RESS) in comparison to magnetization-prepared rapid acquisition gradient echo (MPRAGE) pulse sequence for detecting brain tumors, focusing on its potential to improve diagnostic accuracy and enhance brain tumor assessment.</div></div><div><h3>Methods</h3><div>This single-center prospective study enrolled 20 patients (12 males, aged 35–83), with primary brain tumors and brain metastases. Both MPRAGE and Dixon uT1RESS were acquired at 3 T. Objective image quality was assessed by contrast-to-noise ratio (CNR), tumor-to-brain contrast, and tumor volume. Subjective image quality was assessed by two independent readers focusing on lesion visibility, lesion margins, motion, and static artifacts. A side-by-side comparison assessed diagnostic performance regarding lesion detection, evaluation of internal structure and vascular or dural invasion.</div></div><div><h3>Results</h3><div>Dixon uT1RESS had a reduced acquisition time (2 min 51 s vs. 4 min 52 s for MPRAGE) and showed significantly higher CNR and tumor-to-brain contrast compared to MPRAGE (p &lt; 0.001). Subjectively, both sequences showed similar overall image quality. Dixon uT1RESS achieved more conspicuous lesions with better-defined lesion margins (p &lt; 0.001), while MPRAGE performed better in evaluating internal lesion structure (p &lt; 0.05). Dixon uT1RESS was rated better for lesion detection, with three lesions additionally identified on this sequence. Wilcoxon signed-rank test was used to assess differences.</div></div><div><h3>Conclusions</h3><div>Dixon uT1RESS significantly improved tumor conspicuity and detection, particularly for small metastatic lesions. This new technique offers promising potential for enhancing clinical brain tumor imaging, though additional sequences may be necessary for comprehensive lesion characterization.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112283"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning CAIPIRINHA-accelerated 3D MRI of the knee cartilage at 7 Tesla","authors":"Adrian Alexander Marth ,&nbsp;Thomas Marth ,&nbsp;Georg Constantin Feuerriegel ,&nbsp;Constantin von Deuster ,&nbsp;Dominik Paul ,&nbsp;Marcel Dominik Nickel ,&nbsp;Daniel Nanz ,&nbsp;Reto Sutter","doi":"10.1016/j.ejrad.2025.112287","DOIUrl":"10.1016/j.ejrad.2025.112287","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the feasibility and degree of scan-time reduction that can be achieved by deep learning (DL)-reconstruction in 3D dual-echo steady-state (DESS) knee-cartilage imaging accelerated with CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration) at 7 Tesla (T).</div></div><div><h3>Methods</h3><div>35 knee joints of 18 volunteers were imaged using an isotropic fat-suppressed DL-reconstructed CAIPIRINHA-accelerated DESS sequence (CAIPIRINHA_DL) with an isotropic resolution of 0.25 mm. CAIPIRINHA_DL acquisitions were accelerated four-, six-, eight-, and twelve-fold (CAIPIRINHA_DL4-CAIPIRINHA_DL12), and compared to a state-of-the-art, fourfold accelerated GRAPPA (generalized autocalibrating partially parallel acquisitions) DESS acquisition (GRAPPA₄) with matched spatial resolution. Three readers rated image-quality criteria. Rating differences were characterized with Friedman’s analysis of variance. Inter-reader agreement was assessed for grading of incidental cartilage lesions.</div></div><div><h3>Results</h3><div>CAIPIRINHA_DL6 had the shortest acquisition time (4:04 min) among sequences whose images were rated in the best category, with no statistically significant difference (p &gt; 0.999) to GRAPPA₄ (5:53 min). The overall quality of CAIPIRINHA_DL8 and CAIPIRINHA_DL12 images was rated lower than GRAPPA₄ images, while artifacts were rated significantly more severe (p &lt; 0.001, each). Inter-reader agreement for cartilage lesion grading ranged from almost perfect for CAIPIRINHA_DL4 and GRAPPA₄ (κ = 0.90, each) to moderate for CAIPIRINHA_DL12 (κ = 0.52).</div></div><div><h3>Conclusions</h3><div>The quality of DL-reconstructed 3D DESS images acquired at 7 T with four- and six-fold CAIPIRINHA-based acceleration was equivalent to that of 3D-DESS images acquired with four-fold GRAPPA-based acceleration. These findings suggest the feasibility of DL-reconstructions for imaging of the knee cartilage at 7 T field strength.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112287"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized DWI-based virtual MR elastography for diagnosis and therapeutic monitoring of focal liver lesions","authors":"Xutong Huang ,&nbsp;Wenxin Ma ,&nbsp;Shixian Lu ,&nbsp;Yu Cui ,&nbsp;Zhiwei Qin ,&nbsp;Wenli Tan ,&nbsp;Lingying Huang ,&nbsp;Jie Yuan","doi":"10.1016/j.ejrad.2025.112285","DOIUrl":"10.1016/j.ejrad.2025.112285","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to develop and evaluate an optimized DWI-based virtual MR elastography (vMRE) technique for diagnosing focal liver lesions (FLLs) and monitoring therapeutic responses in malignant tumors, comparing its performance with traditional MRE.</div></div><div><h3>Materials and methods</h3><div>This retrospective analysis of 142 patients with FLLs using six <em>b</em>-value DWI (150–1500 s/mm2) to calculate eight apparent diffusion coefficient (ADC) combinations. Linear regression analysis was performed to evaluate the correlation between ADC and traditional MRE, and a vMRE formula was constructed. Diagnostic performance of vMRE and MRE was compared for FLLs. Prognostic capabilities of both techniques were assessed in malignant tumors using paired t-tests across three response groups at two time points.</div></div><div><h3>Results</h3><div>Significant negative correlations were found between ADC values and MRE stiffness (all <em>P</em> &lt; 0.001), and strongest at <em>b</em> = 200/1500 s/mm² (rho =  − 0.785). vMRE and MRE effectively differentiated benign/malignant lesions (AUCs: 0.957 vs. 0.944, <em>P</em> = 0.440), with vMRE showing higher specificity (95.1 % vs. 85.4 %) and MRE better sensitivity (89.2 % vs. 86.3 %). Longitudinal analysis revealed MRE detected earlier stiffness reductions in partial responders (−31.0 %, <em>P</em> = 0.01), while vMRE showed a non-significant decrease (−12.5 %, <em>P</em> &gt; 0.05). Both modalities identified significant stiffness escalation in progressors (vMRE + 40.1 %, MRE + 43.7 %, both <em>P</em> &lt; 0.01) but not in stable disease (all <em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Optimized DWI-based vMRE effectively differentiates FLLs, offering high specificity for diagnosis and comparable prognostic capabilities to MRE in monitoring malignant tumor responses.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112285"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial unicompartmental knee arthroplasties: Radiographic findings associated with conversion to total knee arthroplasty – A Case control study","authors":"Anna L. Falkowski ,&nbsp;Christoph Germann ,&nbsp;Céline Gfeller ,&nbsp;Fides R. Schwartz ,&nbsp;Thomas Marth ,&nbsp;Sandro F. Fucentese ,&nbsp;Stefan M. Zimmermann ,&nbsp;Reto Sutter","doi":"10.1016/j.ejrad.2025.112284","DOIUrl":"10.1016/j.ejrad.2025.112284","url":null,"abstract":"<div><h3>Purpose</h3><div>Identify radiographic findings after Unicompartmental Knee Arthroplasty (UKA) that might lead to conversion to Total Knee Arthroplasty (TKA) in comparison to an asymptomatic control group without the need to conversion to TKA.</div></div><div><h3>Materials and Methods</h3><div>Radiographs of patients with UKA before aseptic conversion to TKA were compared to an asymptomatic control group without conversion. Radiographic findings like osteolytic rim, osteolysis, material integrity and positioning, periprosthetic fractures, and osteoarthritis (OA) were evaluated.</div></div><div><h3>Results</h3><div>A total of 99 patients were included (male/female, 60/39; mean age, 67 ± 9.7 years), 42 in the conversion group and 57 in the control group. In the conversion group, an osteolytic rim with a sclerotic line was observed at the femoral component in 16.7 % and at the tibial component in 54.8 %, while it was observed in 10.5 % and 30.7 % in the control group (femoral, p = 0.676; tibial, p = 0.014, respectively). Osteolysis was present in the conversion group at the femoral component in 1.2 % and at the tibial component in 8.3 %, while no femoral or tibial component osteolysis was present in the control group (femoral, p = 0.32; tibial, p = 0.008, respectively). OA was more advanced in the conversion group compared to the control group in the lateral femorotibial compartment (p &lt; 0.001) and the patellofemoral compartment (p = 0.008). The femoral material integrity was more often intact in the conversion group (p = 0.045), and the femorotibial ratio was higher in the control group (p = 0.040).</div></div><div><h3>Conclusion</h3><div>Features commonly present in patients needing a conversion from UKA to TKA were tibial osteolytic rim and osteolysis. Additionally, OA was more advanced in the conversion group at the lateral femorotibial compartment and patellofemoral compartment compared to the asymptomatic control group.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112284"},"PeriodicalIF":3.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of CT scanning and metal artefact reduction strategies on measuring knee implant displacement: iMAR – helpful or harmful?","authors":"Maaike A. ter Wee ,&nbsp;Rogier P.J. Speelman ,&nbsp;Johannes G.G. Dobbe ,&nbsp;Arthur J. Kievit ,&nbsp;Mario Maas ,&nbsp;Leendert Blankevoort ,&nbsp;Geert J. Streekstra","doi":"10.1016/j.ejrad.2025.112281","DOIUrl":"10.1016/j.ejrad.2025.112281","url":null,"abstract":"<div><h3>Background</h3><div>A recent development in diagnosing total knee arthroplasty (TKA) tibial component loosening uses Computed Tomography (CT) images of loaded knees to assess implant micro-motion, but metal artefacts can affect reliability. This study investigates the impact of increased exposure and tube voltage, iterative metal artefact reduction reconstruction (iMAR), Sn-filtering and an extended CT scale (ECTS), compared to a standard knee CT protocol on load-induced implant displacement measurement.</div></div><div><h3>Method</h3><div>CT scans of a fresh frozen cadaver leg with a TKA were acquired using a standard protocol and four metal artefact reduction strategies: Increased exposure/tube voltage, iMAR, Sn-filtering, and ECTS reconstruction. Each scan was repeated 10 times with random leg repositioning ensuring no implant-bone motion. Image analysis included implant and proximal tibial cortex segmentation, object registration across scans, and quantification of apparent relative displacement. Grey-level similarity was assessed using the correlation coefficient (CC). Implant displacement error was measured using translation and rotation norms, mean target registration error (mTRE), and maximum total point motion (MTPM).</div></div><div><h3>Results</h3><div>CT scans with metal artefact reduction showed less noise and streaking. Grey-level similarity of the implant was similar across protocols (CC = 0.88). iMAR had the highest bone similarity (CC = 0.99). Implant displacement errors were comparable for increased exposure/tube voltage, Sn-filtering and ECTS (median: 0.08 mm translation, 0.13° rotation, 0.09 mm mTRE, 0.14 mm MTPM). However, iMAR statistically significantly increased median rotation norm to 0.19˚.</div></div><div><h3>Conclusion</h3><div>Increased exposure/tube voltage, Sn-filtering, and ECTS do not impact the measurement error of 3D CT-based knee implant loosening detection. iMAR showed increased rotational error while other displacement parameters remained unchanged, suggesting it may be less suitable for quantifying implant displacement.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112281"},"PeriodicalIF":3.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary synthetic MRI study on Achilles tendon dynamics in amateur marathoners","authors":"Liting Hou ,&nbsp;Junfei Li ,&nbsp;Xuesong Zhang ,&nbsp;Jianan Chen ,&nbsp;Hailun Bao ,&nbsp;Fan Yang ,&nbsp;Baohai Yu ,&nbsp;Jian Zhao","doi":"10.1016/j.ejrad.2025.112279","DOIUrl":"10.1016/j.ejrad.2025.112279","url":null,"abstract":"<div><h3>Objective</h3><div>To observe alterations in the microstructure and chemical composition of the Achilles tendon (AT) in amateur marathon runners before and after a race using synthetic magnetic resonance imaging (SyMRI).</div></div><div><h3>Methods</h3><div>SyMRI examinations were performed on marathoners at three-time points: pre-race, 48 h post-race, and 2 months post-race. A control group also underwent SyMRI examinations. The AT was segmented into three regions: the muscle–tendon junction (MTJ), insertion (INS), and middle (MID) regions. T1 and proton density (PD) values were recorded in these regions. We compared T1 and PD values between the marathoners and controls at different time points.</div></div><div><h3>Results</h3><div>The study included 15 marathoners (11 males, 4 females; mean age 41.6 ± 5.36 years) and 10 controls (7 males, 3 females; mean age 36.3 ± 8.77 years). T1 values in the INS region were significantly lower in marathoners than in controls (<em>p</em> &lt; 0.05). At 48 h post-race, T1 values increased significantly in the INS region (12.1 % increase, <em>p</em> &lt; 0.01), while PD values decreased across all three regions (12.1 %-21.3 % decrease, all <em>p</em> &lt; 0.01). At 2 months post-race, T1 values in the INS region decreased compared to 48 h post-race (12.6 % decrease, <em>p</em> &lt; 0.05), and PD values in the MTJ and INS regions increased (MTJ: 64.7 % increase, INS: 112.9 % increase, both <em>p</em> &lt; 0.05). No significant differences in T1 and PD values were observed between 2 months post-race and pre-race.</div></div><div><h3>Conclusion</h3><div>Changes in T1 and PD values of the AT following a marathon are reversible. SyMRI quantitative parameters can indicate microscopic changes in the AT, with PD values being the more sensitive indicator.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112279"},"PeriodicalIF":3.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of image quality of 40 keV virtual monoenergetic images of vertebral arteries using DLIR and ASIR-V algorithms under a dual-low scanning protocol","authors":"Ying Tang ,&nbsp;Haini Zhang ,&nbsp;Lihui Chen ,&nbsp;Meng Yu ,&nbsp;He Zhang ,&nbsp;Dapeng Zhang ,&nbsp;Yang Wu ,&nbsp;Zhongxiao Liu ,&nbsp;Aiyun Sun ,&nbsp;Yankai Meng ,&nbsp;Kai Xu","doi":"10.1016/j.ejrad.2025.112276","DOIUrl":"10.1016/j.ejrad.2025.112276","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to compare the image quality of 40 keV Virtual Monoenergetic Images (VMI) of the vertebral artery (VA) reconstructed using two algorithms, Deep Learning Image Reconstruction (DLIR) and Adaptive Statistical Iterative Reconstruction (ASIR-V), under a dual-low scanning protocol, which simultaneously reduces both the radiation dose and the contrast agent dose during the CT scanning process.</div></div><div><h3>Methods</h3><div>A total of 88 patients were randomly assigned to an experimental group (n = 44) and a control group (n = 44). Both groups underwent dual-energy carotid CT angiography (DE-CTA) with a contrast agent dose of 0.5 ml/kg. The experimental group [Noise Index (NI) = 11.0] used DLIR at high-strength (DLIR-H) and medium-strength setting (DLIR-M), along with Adaptive Statistical Iterative Reconstruction algorithm set at 50 % strength (ASIR-V 50 %), while the control group (NI = 4.0) used ASIR-V 50 %. Image quality was evaluated both objectively [using CT values, noise, Signal-to-Noise Ratio (SNR), and Contrast-to-Noise Ratio (CNR)] and subjectively [using a 5-point scale for image noise, vascular contours, curve planar reformation (CPR), and overall image quality].</div></div><div><h3>Results</h3><div>The experimental group demonstrated a 44.4 % reduction in effective radiation dose compared to the control group (0.85 mSv and 1.53 mSv, respectively, <em>P</em> &lt; 0.001). DLIR algorithms, especially DLIR-H, significantly reduced image noise and improved both SNR and CNR compared to ASIR-V 50 % (<em>P</em> &lt; 0.01). Subjective evaluation revealed that more than 70 % of the images in the experimental group scored above 4 points, indicating excellent image quality. Furthermore, DLIR-H outperformed both ASIR-V 50 % and DLIR-M in both objective and subjective image quality assessments (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>The DLIR algorithm, particularly DLIR-H, significantly improves the quality of 40 keV VMI of the vertebral artery under a dual-low scanning protocol. DLIR-H provides superior image quality with reduced radiation exposure, making it a promising option for clinical applications in patients with posterior circulation ischemic stroke. These findings are important for clinical practice as they suggest that DLIR-H can enhance diagnostic accuracy while minimizing risks associated with radiation exposure, particularly in vulnerable patient populations.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112276"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of brain atrophy in focal epilepsy","authors":"Stefanie Chambers ,&nbsp;Leo Hofer ,&nbsp;Patric Kienast ,&nbsp;Christoph Baumgartner ,&nbsp;Johannes Koren ,&nbsp;Giuseppe Pontillo ,&nbsp;Christian Dorfer ,&nbsp;Karl Rössler ,&nbsp;Judith Jud ,&nbsp;Silvia Bonelli ,&nbsp;Susanne Aull-Watschinger ,&nbsp;Frederik Barkhof ,&nbsp;Ekaterina Pataraia ,&nbsp;Gilbert Hangel ,&nbsp;Gregor Kasprian ,&nbsp;Lukas Haider","doi":"10.1016/j.ejrad.2025.112278","DOIUrl":"10.1016/j.ejrad.2025.112278","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy as a progressive disease is a topic of dispute, with only limited evidence supportive of a neurodegenerative hypothesis across structural etiologies other than hippocampal sclerosis.</div></div><div><h3>Methods</h3><div>We performed cross-sectional brain volumetry on T1-weighted MRI scans in 59 people with drug-resistant focal epilepsy (PWFE), who had undergone extensive evaluation at a tertiary epilepsy center and were compared to three independent age-and sex-matched healthy control cohorts. 36 (61%) PWFE showed structural pathologies such as malformations of cortical development, low-grade epilepsy-associated neuroepithelial tumours and hippocampal sclerosis or encephaloceles, 23 (19%) PWFE were MRI-negative.</div></div><div><h3>Results</h3><div>59 PWFE (female/male: 25/34, mean age 32.4 years, SD: 10.5) presenting with a median seizure frequency score (SFS) of 7 (range 1–10) and mean epilepsy duration of 14.3 years (SD: 9.9) were compared to 59 healthy control subjects (f/m: 33/26, mean age 33.7 years, SD 9.9).</div><div>Adjusted for effects of age and gender, cortical gray matter volume in PWFE with a high SFS (≥ 7) was decreased by 30.1 ml (CI: −46.92 ml – −13.34 ml, p &lt; 0.001).</div><div>Similar results were observed for total deep gray matter volume, decreasing −4.35 ml (CI: −6.13 ml – −2.58 ml, p &lt; 0.001) and white matter volume −40.65 ml (CI: −57.70 ml – −23.59 ml, p = 0.001) in patients suffering from a high seizure frequency. This effect was not significantly influenced by the structural etiology, seizure severity, nor lesion location.</div></div><div><h3>Conclusions</h3><div>Widespread brain volume loss, exceeding that of normal aging, shows correlation with a high seizure frequency irrespective of structural etiology in focal epilepsy.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112278"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of MRI-based surveillance for high-risk individuals for pancreatic cancer","authors":"Raffaella M. Pozzi Mucelli ,&nbsp;Miroslav Vujasinovic ,&nbsp;Ana Farah-Mwais ,&nbsp;Peter Gustavsson ,&nbsp;Carlos Fernández Moro ,&nbsp;Poya Ghorbani ,&nbsp;Johannes-Matthias Löhr ,&nbsp;Nikolaos Kartalis","doi":"10.1016/j.ejrad.2025.112275","DOIUrl":"10.1016/j.ejrad.2025.112275","url":null,"abstract":"<div><h3>Purpose</h3><div>Surveillance is recommended in high-risk individuals (HRIs) for pancreatic cancer (PC), as it seems effective in detecting malignant/premalignant lesions. Most surveillance programs are based on a combination of MRI and endoscopic ultrasound.</div><div>This study aimed to evaluate the incidence of relevant imaging findings (PC and lesions with high-grade dysplasia) and the performance of MRI-based surveillance in a single-centre HRIs cohort.</div></div><div><h3>Methods</h3><div>Single-centre, retrospective study on 274 prospectively collected HRIs (2002–2023). Surveillance was performed exclusively with MRI from 2010; MRI and/or CT in 2002–2009. MRI findings, demographic, clinical, and histopathological data were recorded. Diagnostic accuracy measures for the surveillance program were calculated.</div></div><div><h3>Results</h3><div>The median follow-up was 5.8 years. Focal lesions were detected in 59 % of the patients: cysts in 56 % (152/274), cystic and solid lesions in 3 % (8/274), and solid lesions in 1 % (2/274). Four patients (1 %, 4/274) had suspicious cysts (3 resected; no high-grade dysplasia at histopathology). Six patients (2 %; 6/274) had PC: two in stage I (0.7 %), one in stage II (0.4 %), three in stage IV (1.1 %). Three out of six patients had liver metastases at diagnosis. Surveillance diagnostic accuracy measures: sensitivity 67 % (95 %CI 22–96 %), specificity 98 % (95 %CI 96–99 %), positive predictive value (PPV) 44 % (95 %CI 14–79 %), negative predictive value 99 % (95 %CI 97–99 %).</div></div><div><h3>Conclusions</h3><div>The incidence of PC in HRIs was low (0.32 per 100-person-years), with similar proportion of stage I and IV PC. No lesions with high-grade dysplasia were identified. Sensitivity and PPV were low, suggesting that early diagnosis of PC in MRI surveillance setting is challenging.</div><div>Keywords (Mesh terms)</div><div>Pancreas, Pancreatic Cancer, Early Diagnosis, Surveillance, MRI, Incidence.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"Article 112275"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}