European Journal of Radiology最新文献

{"title":"Corrigendum to \"Degeneration of the cartilage quality is correlated with a higher intramuscular fat infiltration of the vastus medialis in older adults with pre-to-mild knee osteoarthritis\" [Eur. J. Radiol. 183 (2025) 111930].","authors":"Shogo Okada, Masashi Taniguchi, Masahide Yagi, Yoshihiro Fukumoto, Tetsuya Hirono, Momoko Yamagata, Ryusuke Nakai, Masashi Kobayashi, Noriaki Ichihashi","doi":"10.1016/j.ejrad.2025.112343","DOIUrl":"10.1016/j.ejrad.2025.112343","url":null,"abstract":"","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"112343"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of photon-counting CT-derived attenuation parameters for noninvasive liver fat assessment.","authors":"Dingbo Shu, Jianping Wang, Ding Liang, Zhenhua Zhao, Jianfeng Yang","doi":"10.1016/j.ejrad.2025.112354","DOIUrl":"10.1016/j.ejrad.2025.112354","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic performance of multiple photon-counting CT (PCCT)-derived parameters for hepatic fat quantification, using MRI-derived proton density fat fraction (PDFF) as the reference standard.</p><p><strong>Methods: </strong>This prospective study included 59 adult participants who underwent both MRI and PCCT within 2 h. Standardized CT values, Liver-virtual non-contrast (VNC) fat fraction, and liver-to-spleen/fat-derived indices (L-S, L/S, L-F, L + F, L/F) were obtained from non-contrast PCCT. MRI PDFF was derived using a 6-echo q-Dixon sequence. Pearson and Spearman correlation analyses were used to assess the association between PCCT-derived parameters and MRI PDFF. Linear mixed-effects model (LMM) was performed to establish a conversion formula between CT attenuation and MRI PDFF.</p><p><strong>Results: </strong>All PCCT-derived parameters were significantly correlated with MRI PDFF. Standardized CT values demonstrated the strongest correlation (r = -0.94, p < 0.001), followed by L-S (r = -0.90, p < 0.001), L/F (r = 0.89, p < 0.001), and L/S (r = -0.88, p < 0.001). Liver-VNC fat fraction showed a relatively lower correlation (r = 0.84, p < 0.001). LMM revealed a significant association between standardized CT values and MRI PDFF (β = -0.55, p < 0.001), with the regression equation: MRI PDFF (%) = -0.55 × CT (HU) + 41.</p><p><strong>Conclusion: </strong>Among various attenuation-based PCCT parameters, the standardized CT value shows the strongest correlation with MRI PDFF and is clinically easy to obtain. It may serve as a promising noninvasive alternative to MRI for hepatic fat quantification. However, due to the limited sample size, these findings should be interpreted with caution.</p>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"191 ","pages":"112354"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated detection of pyogenic liver abscess and diagnosis of Klebsiella pneumoniae infection based on CECT images with deep learning: A multicenter study","authors":"Junxi Zhou ,&nbsp;Xiuyun Peng ,&nbsp;Yi Yang ,&nbsp;Zhenqiu Shang ,&nbsp;Xinyan Feng ,&nbsp;Ye Chen ,&nbsp;Qing Wang ,&nbsp;Qiaoling Yan ,&nbsp;Hao Zeng ,&nbsp;Yaqing Chen ,&nbsp;Neng Wang ,&nbsp;Yiping Zhang ,&nbsp;Enguang Zou ,&nbsp;Ning Dong ,&nbsp;Gang Chen ,&nbsp;Yi Wang","doi":"10.1016/j.ejrad.2025.112462","DOIUrl":"10.1016/j.ejrad.2025.112462","url":null,"abstract":"<div><h3>Background</h3><div>Accurate identification of bacterial pathogens in pyogenic liver abscess (PLA) remains challenging in low- and middle-income countries (LMICs). We developed and validated an artificial intelligence (AI) model that replicates clinical workflow to detect and diagnose <em>Klebsiella pneumoniae</em> liver abscess (KPLA) using contrast-enhanced computerized tomography (CECT).</div></div><div><h3>Methods</h3><div>Patients with PLA were enrolled from three medical centers between April 2011 and April 2024. The Pyogenic Liver Abscess Detection with AI (PLADA) system employed a V-Net deep neural network for automated lesion segmentation. Radiomics features were subsequently extracted and ranked by importance. Six machine learning algorithms were used to develop clinical, radiomics, and integrated clinical-imaging models for KPLA diagnosis in the training cohort, with external validation in a multicenter framework.</div></div><div><h3>Results</h3><div>A total of 492 PLA patients were identified. The PLADA algorithm accurately segments the lesions with a mean dice coefficient of 0.941 (95 % confidence interval: 0.899–0.983). The clinical-imaging model demonstrated strong discriminatory performance, with a mean area under the curve (AUC) of over 0.9 across all algorithms in the training cohort. The AdaBoost-based clinical-imaging model achieved an AUC of 0.847 (95 % CI: 0.753–0.940) in the external validation cohort, with high sensitivity (71.9 %) and specificity (86.4 %). Decision curve analysis (DCA) confirmed clinical utility.</div></div><div><h3>Conclusions</h3><div>The PLADA system provides an accurate, non-invasive method for KPLA diagnosis through a clinically interpretable two-stage AI framework. While limited by a retrospective, single-country dataset, this approach shows particular promise for early detection<!--> <!-->of KPLA in resource-limited settings.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112462"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of rectal MRI prior to endoscopic submucosal dissection (ESD): an exploratory study","authors":"Marc J. Gollub ,&nbsp;Maria Clara Fernandes ,&nbsp;Wyanne Law ,&nbsp;Makoto Nishimura ,&nbsp;Lee Rodriguez ,&nbsp;Sayaka Nagao ,&nbsp;Jinru Shia ,&nbsp;Julio Garcia-Aguilar ,&nbsp;Martin R. Weiser ,&nbsp;Junting Zheng ,&nbsp;Marinela Capanu","doi":"10.1016/j.ejrad.2025.112447","DOIUrl":"10.1016/j.ejrad.2025.112447","url":null,"abstract":"<div><h3>Purpose</h3><div>To correlate rectal MRI findings with endoscopic margin status and depth of invasion in patients undergoing endoscopic submucosal dissection (ESD) for rectal adenomas and early rectal cancers.</div></div><div><h3>Methods</h3><div>Pre-treatment MRIs of patients with colonoscopy-detected polyps and early rectal cancer undergoing curative-intent ESD from 2018 to 2023 were re-interpreted by two radiologists (3- and 25-years’ experience) blinded to outcomes. MRI features assessed included largest and smallest length, T2 signal intensity, degree of wall attachment, diffusion restriction and apparent diffusion coefficient values. The reference standard was histopathology. Associations between MRI features and outcomes were tested with Fisher’s exact test and Wilcoxon rank sum test. Inter-rater agreement was assessed with kappa statistics and intraclass correlation coefficient.</div></div><div><h3>Results</h3><div>In 21 patients (median age, 64 years [interquartile range, 54–75]; 12 (57 %) female), final ESD histopathology showed 12 (57 %) adenocarcinomas and 9 (43 %) adenomas. R0 resections were achieved in 11/21 ESD procedures (52.3 %, 95 % CI: 30–74 %). Depth of invasion was correct in 6/21 and 5/21 cases (29 % and 24 %, 95 % CI: 11–52 % and 8–47 %), for 2 readers, respectively. Significant associations with R0 resection for both readers included: smaller mass size (long axis; p = 0.005, 0.003, short axis; p = 0.018, 0.022) and lower degree of wall attachment (p = 0.001, 0.011). Agreement on these three measures was good to low (ICC = 0.87, 0.80, and 0.39), respectively.</div></div><div><h3>Conclusions</h3><div>In this hypothesis-generating exploration of MRI findings of adenomas and early rectal cancers undergoing ESD, MRI polyp size and degree of wall attachment showed strong negative associations with tumor-free resection margins.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112447"},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of scanning parameters on image quality, and repeatability of renal blood oxygenation level-dependent imaging: A preliminary study on 5 T MRI","authors":"Ying Xiong ,&nbsp;Chuanjiang Guan ,&nbsp;Shaoxin Xiang ,&nbsp;Wenbing Zeng ,&nbsp;Ting Rong ,&nbsp;Zhichao Feng ,&nbsp;Yun Wen ,&nbsp;Junfeng Kong","doi":"10.1016/j.ejrad.2025.112460","DOIUrl":"10.1016/j.ejrad.2025.112460","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the influence of scanning parameters on image quality and the repeatability of renal Blood Oxygenation Level-Dependent (BOLD) imaging at 5 T.</div></div><div><h3>Methods</h3><div>20 healthy subjects and 25 patients with chronic kidney disease (CKD) were prospectively recruited for BOLD-MRI scans at 5 T using multiple parameter combinations. The Fisher’s exact test, ANOVA, the Friedman test, and paired t-tests were used to compare the qualitative and quantitative indices across groups. The generalized linear models (GLM) analysis was further used to evaluate the effect of acquisition parameters on the measured R2* values. Subsequently, Pearson correlation and the intraclass correlation coefficient (ICC) were applied to assess the repeatability of R2* values in the high-resolution parameters in patients.</div></div><div><h3>Results</h3><div>Renal cortical and medullary R2* values demonstrated excellent agreement (all ICCs &gt; 0.75) across varied in-plane resolution, slice thickness, echo number, and maximum TE. GLM revealed a significant positive effect of slice thickness on R2* in both cortex and medulla, a region-specific positive effect of maximum TE in the cortex only, and no significant effect of in-plane resolution or echo number. High resolution (1.25 mm × 1.25 mm × 3 mm) provided superior corticomedullary demarcation and clinical image quality, and renal cortical and medullary R2* values exhibited high inter-observer agreement (<em>ICC</em>: 0.992 and 0.971) and test–retest repeatability (all <em>r</em> &gt; 0.90, <em>P</em> &lt; 0.05). Compared with healthy subjects, the renal cortical and medullary R2* values in patients with CKD were significantly higher (cortical R2*: 21.13 Hz vs. 22.88 Hz, <em>P</em> &lt; 0.001; medullary R2*: 40.69 Hz vs. 49.14 Hz, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>This study showed that image resolution may slightly affect the quantification of the R2* values on 5 T renal BOLD-MRI. High-resolution BOLD imaging (1.25 mm × 1.25 mm × 3 mm, 10 echoes, maximum TE 40 ms) can be achieved at 5 T MRI with excellent inter-observer agreement and test–retest repeatability, validating its clinical applicability.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112460"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional lateral tilt can be a good assessment of lateral patellar maltracking","authors":"Mao Yuan ,&nbsp;Yurou Chen ,&nbsp;Furong Lv ,&nbsp;Bo Sheng ,&nbsp;Shixin Nie ,&nbsp;Jia Li","doi":"10.1016/j.ejrad.2025.112457","DOIUrl":"10.1016/j.ejrad.2025.112457","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the correlation between patellar tilt and shift based on 4D-CT scans, and compare the value of 2D and 3D parameters in evaluating lateral patellar maltracking in patients with patella dislocation.</div></div><div><h3>Methods</h3><div>Bisect offse index, lateral patellar tilt, 3D shift and 3D tilt were evaluated in 42 knees of patella dislocation patients and 42 knees of controls. 3D shift was defined as shift of the center of gravity of the patella relative to the origin in the <em>X</em>-axis direction. 3D tilt was defined as the spatial angle between the horizontal axis of the patella and the <em>X0Z</em> plane.</div></div><div><h3>Results</h3><div>The trends of 3D shift, 3D tilt, bisect offse index, and lateral patellar tilt with knee flexion angle were different between the two groups (all <em>p</em> &lt; 0.001). When the knee was fully extended and flexed at 30°, 45°, and 60°, the 3D tilt and lateral patellar tilt in the patella dislocation group was significantly higher than that in the control group (All <em>p</em> &lt; 0.001 for 3D tilt/ <em>p</em> &lt; 0.001, <em>p</em> = 0.002, <em>p</em> = 0.005, and <em>p</em> &lt; 0.001 for lateral patellar tilt, respectively).3D shift was strong correlated with 3D tilt (r = 0.722, <em>p</em> &lt; 0.001); bisect offse index was moderately correlated with lateral patellar tilt (r = 0.697, <em>p</em> &lt; 0.001). The AUC values for 3D shift and 3D tilt at all different flexion angles were 0.931 and 0.955, respectively. The AUC values of bisect offse index and lateral patellar tilt at all different flexion angles were 0.964 and 0.971, respectively.</div></div><div><h3>Conclusion</h3><div>When assessing the axial alignment of the patellofemoral joint, it may not be necessary to use both 3D shift and 3D tilt of the patella simultaneously. This could allow surgeons to describe patellar alignment more simply and streamline the preoperative evaluation process. Clinicians should focus on patellar tilt and shift in the full extension during dynamic examination.</div><div>Level of Evidence: Level III.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112457"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Predictive model based on mesorectal fat radiomics for pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer” [Eur. J. Radiol. 192 (2025) 112378]","authors":"Shuhong Fan ,&nbsp;Ning Wang ,&nbsp;Yi Wen ,&nbsp;Weicai Shi ,&nbsp;Yonghe Chen ,&nbsp;Kaikai Wei","doi":"10.1016/j.ejrad.2025.112421","DOIUrl":"10.1016/j.ejrad.2025.112421","url":null,"abstract":"","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112421"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in tumor morphology and body composition following neoadjuvant chemotherapy predict progression-free survival in adenocarcinoma of the esophagogastric junction: A multi-center study","authors":"Chenglong Luo ,&nbsp;Wanling Mu ,&nbsp;Haojie Zhang ,&nbsp;Xinhua Meng ,&nbsp;Youxin Zhang ,&nbsp;Yusai Mu ,&nbsp;Mengchen Yuan ,&nbsp;Yue Zhou ,&nbsp;Liming Li ,&nbsp;Changmao Ding ,&nbsp;Xuejun Chen ,&nbsp;Ming Li ,&nbsp;Jing Li ,&nbsp;Jianbo Gao","doi":"10.1016/j.ejrad.2025.112461","DOIUrl":"10.1016/j.ejrad.2025.112461","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the predictive value of longitudinal changes in tumor morphology and body composition during neoadjuvant chemotherapy (NAC) for progression-free survival (PFS) following radical resection of adenocarcinoma of the esophagogastric junction (AEG).</div></div><div><h3>Methods</h3><div>This retrospective study included 258 AEG patients receiving NAC at three hospitals. Clinical and pathological data were collected. Tumor morphological and body composition parameters were quantitatively assessed on venous phase CT images at pre-treatment (Pre) and post-treatment (Post) time points. The two measurements were compared and the reduction rate (Δ%) was calculated. Multivariate Cox regression analysis was used to identify independent predictors of PFS in AEG patients and a nomogram model was developed. The incremental predictive value of tumor morphological and body composition parameters was evaluated using the concordance index (C-index), net reclassification improvement, and integrated discrimination improvement. The goodness-of-fit of models was assessed via the Akaike information criterion and χ² likelihood ratio test. The performance of the nomogram was evaluated by the area under the time-dependent receiver operating characteristic (tdROC) curve, calibration curves, and decision curve analysis. High-risk and low-risk subgroup analyses were performed according to nomogram scores.</div></div><div><h3>Results</h3><div>Multivariate Cox regression analysis showed that ypTNM staging, Post-tumor volume, and Δ%-skeletal muscle index (SMI) were independent predictors of PFS. The nomogram incorporating these predictors demonstrated significantly superior discrimination over ypTNM staging alone in both the training cohort (C-index: 0.744; 95 % CI: 0.670–0.790; <em>P</em> = 0.004) and an external validation cohort (C-index: 0.738; 95 % CI: 0.615–0.807; <em>P</em> = 0.024). tdROC analysis showed that the nomogram achieved area under the curve (AUC) values of 0.815 and 0.791 for predicting 1- and 2-year PFS, respectively, in the training cohort. These findings were corroborated in the external validation cohort, with corresponding AUCs of 0.761 and 0.746 for 1- and 2-year PFS, respectively. Moreover, according to the score of the nomogram, patients can be effectively divided into low-risk and high-risk groups.</div></div><div><h3>Conclusion</h3><div>The nomogram, incorporating ypTNM staging, Post-tumor volume, and Δ%-SMI, demonstrated robust performance in predicting PFS in AEG patients. This model significantly outperformed traditional ypTNM staging alone and may help guide personalized postoperative monitoring strategies.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112461"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep-learning reconstructed 3D MRI for comprehensive knee assessment: Comparison with a multisequence 2D protocol at 1.5 T","authors":"Elizabet Nikolova ,&nbsp;Jonas Kroschke ,&nbsp;Carina Obermüller ,&nbsp;Fabio Zecca ,&nbsp;Karolina Pawlus ,&nbsp;Lisa Jungblut ,&nbsp;Thomas Rauer ,&nbsp;Falko Ensle","doi":"10.1016/j.ejrad.2025.112458","DOIUrl":"10.1016/j.ejrad.2025.112458","url":null,"abstract":"<div><h3>Objective</h3><div>To compare a single isotropic 3D PD-weighted fat-saturated (3D-PDFS) acquisition with a standard 2D multisequence protocol in knee MRI using deep learning reconstruction (DLR) for comprehensive assessment of knee structures.</div></div><div><h3>Materials and Methods</h3><div>We retrospectively collected consecutive adult patients undergoing 1.5 T knee MRI between May 2023 and July 2024. The MRI protocol comprised one 3D-PDFS and five multiplanar 2D sequences with DLR. Two radiologists independently evaluated the 3D and 2D sequences, assessing abnormalities for medial (MC), lateral (LC), and patellofemoral (PF) compartments, overall image quality, diagnostic confidence, and artifacts. Likert-scale and binary grades were compared via Wilcoxon signed-rank and McNemar tests, respectively. Inter-reader agreement was assessed via Cohen’s kappa.</div></div><div><h3>Results</h3><div>A total of 95 patients (females, 39 %; age, 52.7 ± 14.5 y) were included. The 3D and 2D protocols did not significantly differ regarding the assessment of menisci, MC and PF cartilage, collateral ligaments, cruciate ligaments, MC and PF bone marrow edema (BME), and fractures (p &gt; 0.057). Significant differences were shown in assessment of LC cartilage (p = 0.002), LC BME (p = 0.040) and synovitis (p = 0.002). Image quality and artifacts were not significantly different (p &gt; 0.082). Diagnostic confidence of one reader was significantly higher for the 2D protocol (p = 0.023). Average inter-reader agreement was substantial for the 3D (k = 0.67) and 2D (k = 0.66) protocols.</div></div><div><h3>Conclusion</h3><div>Our results suggest mostly comparable performance between a single 3D-PDFS and a multisequence 2D protocol using DLR for knee assessment, with the exception of few structures.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112458"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gray matter microstructural abnormalities in temporal lobe epilepsy with hippocampal sclerosis and MRI negative","authors":"Wenrui Yang ,&nbsp;Jiandong Niu ,&nbsp;Yuhui Xiong ,&nbsp;Xucong Wang ,&nbsp;Jian Li ,&nbsp;Zhuo Wang ,&nbsp;Dengyan Song ,&nbsp;Bing Chen","doi":"10.1016/j.ejrad.2025.112455","DOIUrl":"10.1016/j.ejrad.2025.112455","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the changes of cortical microstructure in patients with temporal lobe epilepsy combined with hippocampal sclerosis (TLE-HS) and MRI-negative TLE (negative-TLE) and its correlation with clinical characteristics.</div></div><div><h3>Methods</h3><div>A total of 59 TLE-HS patients, 47 negative-TLE patients, and 67 healthy controls (HC) participated in this study. Gray matter-based spatial statistics (GBSS) analysis was performed using neurite orientation dispersion and density imaging (NODDI) data to compare differences in gray matter (GM) microstructure across the groups, including neurite density index (NDI), orientation dispersion index (ODI). Microstructural indicators were determined to be statistically significant using the threshold-free cluster enhancement method, and multiple comparisons were corrected using the family-wise error (FWE) method. <em>P</em>_FWE &lt; 0.05 was considered statistically significant. The correlation between the indicator values of significantly different brain regions and clinical characteristics was also analyzed.</div></div><div><h3>Results</h3><div>Compared with the HC group, TLE-HS exhibited widespread reductions in NDI and ODI values within GM, and these changes were primarily affecting the bilateral frontotemporal lobes and limbic system. In contrast to the negative-TLE group, the decrease in NDI in TLE-HS patients was more localized and showed partial lateralization. This decrease was most pronounced in the bilateral frontal pole, frontal gyrus, left temporal pole, temporal gyrus, parahippocampal gyrus, insula, precuneus, cingulate gyrus, and anterior and posterior central gyrus. The NDI values in several gray matter regions in TLE patients were positively correlated with disease onset age, with moderate positive correlations predominantly observed in the middle frontal gyrus, temporal pole, and parahippocampal gyrus. Additionally, NDI values in the parahippocampal gyrus were negatively correlated with disease duration.</div></div><div><h3>Conclusion</h3><div>TLE-HS patients show extensive GM microstructural changes, primarily in the frontotemporal lobe and limbic system. Our findings support the hypothesis that TLE-HS and MRI-negative TLE represent two distinct pathological entities. This study provides strong evidence of the pattern of microstructural alterations in TLE and offers insights into the understanding of GM microstructural changes in TLE patients.</div></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":"193 ","pages":"Article 112455"},"PeriodicalIF":3.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}