European journal of hospital pharmacy : science and practice最新文献

{"title":"Paracetamol loading dose administration in children: a retrospective study.","authors":"Alise D E de Groot, Marijke A J van der Wagt, Nieko C Punt, Daan J Touw, Henkjan J Verkade, Paola Mian","doi":"10.1136/ejhpharm-2025-004496","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004496","url":null,"abstract":"<p><strong>Objective: </strong>To determine the extent to which recommended paracetamol loading doses are administered in an academic paediatric hospital and to determine whether paracetamol loading doses are necessary to achieve the therapeutic target concentration of 10 mg/L in (pre)term neonates and children.</p><p><strong>Methods: </strong>A retrospective study was performed including (pre)term neonates and children who were hospitalised between 1 January 2023 and 1 January 2024 and received at least one dose of intravenous or rectal paracetamol. The number of treatments with and without a paracetamol loading dose was evaluated. Pharmacokinetic simulations were performed to determine the effect of the loading dose on paracetamol steady-state concentrations (C_ss).</p><p><strong>Results: </strong>We included 911 intravenous and 1402 rectal treatment periods, with loading doses administered in 21% and 1% of the cases, respectively. Pharmacokinetic simulations show that an intravenous or rectal loading dose reaches C_ss concentrations within the first dose, while without a loading dose, C_ss is only reached after 12 hours for intravenous and 18 hours for rectal administration.</p><p><strong>Conclusion: </strong>Our results indicate that in most cases, paracetamol loading doses are not administered in an academic paediatric hospital, which will strongly delay paracetamol C_ss. We conclude that the treatment of (pre)term neonates and children with paracetamol can and should be improved.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of type of delivery method on medicine waste in households: a questionnaire-based study on outpatients receiving cost-free medicine in the North Denmark Region.","authors":"Anne Estrup Olesen, Helena Birk Wisby, Maja Beck Mejlholm, Mille Vraa Gamborg Eisenhardt, Iben Bang Andersen, Lisa Greve Routhe","doi":"10.1136/ejhpharm-2024-004420","DOIUrl":"https://doi.org/10.1136/ejhpharm-2024-004420","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing number of patients challenges healthcare and drives demand for home-based treatments. In the North Denmark Region, outpatients can acquire their hospital medication as 'cost-free medicine' through home delivery or medication pickup lockers. With a focus on home-based treatments and limited household medicine tracking, investigating medicine waste is crucial for resource optimisation. This study aimed to investigate the prevalence of excess medication among outpatients in the North Denmark Region, whether there was an association between excess cost-free medicine and type of delivery method, and reasons for the excess.</p><p><strong>Methods: </strong>This study included outpatients from the Department of Neurology or Department of Gastroenterology at Aalborg University Hospital receiving cost-free medication from March to October 2023. Eligible outpatients received a questionnaire via Digital Post. As medicine waste is difficult to measure directly, excess medication was used as a surrogate measure. Patient data were acquired through Apovision and stored in REDCap. Pearson's χ² test was performed to examine the difference in excess medicine between medication pickup locker and home delivery.</p><p><strong>Results: </strong>52.8% (233/441) of outpatients reported excess cost-free medication at home. Medication pickup lockers, where 58.9% (132/224) reported an excess, were associated with larger medicine stocks at home compared with home delivery where 46.5% (101/217) reported excess (p=0.009). For 45.5% (106/233) of medicine pickup locker users and 24% (56/233) of home delivery users, the excess was planned with the hospital department. If the excess was not planned with the department, most users reported receiving too much medicine (23/76) or 'Other' (42/76).</p><p><strong>Conclusions: </strong>Over half of the outpatients reported excess cost-free medication, with the largest excess linked to medication pickup lockers. Patients managing their own pickup tend to accumulate more. To minimise accumulation of medicine for personal use, it may be worth investigating whether deliveries through medication pickup lockers should be scheduled at fixed intervals.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A collaborative telepharmacy model for dispensing and informed delivery from hospital to community pharmacies.","authors":"Esther Vicente-Escrig, Antonio Solana-Altabella, Maria José Company-Albir, Mayte Gil-Candel, Raul Ferrando-Piqueres, Maria Dolores Belles-Medall","doi":"10.1136/ejhpharm-2025-004524","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004524","url":null,"abstract":"<p><strong>Background: </strong>This study examines the implementation of a collaborative telepharmacy programme in an outpatient pharmaceutical care unit (OPCU) at a tertiary hospital. The programme coordinates between the hospital pharmacy, community pharmacies, a pharmaceutical distributor, and the regional official college of pharmacists to optimise medication dispensing and delivery to outpatients.</p><p><strong>Methods: </strong>The programme addressed challenges in operations, logistics, technology, legality, training and information. A protocol was developed defining the collaborative dispensing circuit, including criteria for patient selection and prioritisation.</p><p><strong>Results: </strong>Over 39 months, 13 310 shipments were made to 1039 patients, averaging 17 daily. Each patient received about 13 deliveries. A total of 14 283 medications from 258 specialties were dispensed. The programme saved 512 534 km and 542 164 min (356 days) in travel. Each patient saved approximately 493 km and 522 min, reducing CO2 emissions by 58-116 kg per patient, or 72-145 tonnes overall. A survey of 130 patients revealed a 93% preference for this model over home or healthcare facility delivery.</p><p><strong>Discussion: </strong>The implementation of telepharmacy programmes for dispensing hospital medication to community pharmacies marks a significant advancement in patient care. Initially rare, telepharmacy is now widespread, overcoming previous barriers. Programmes show similar effectiveness to home delivery, improving workflow and safety. Future improvements may include remote monitoring tools and video calls. Despite some limitations, such as economic analysis and tracking, telepharmacy has proven beneficial for patients, offering cost savings and enhanced confidentiality.</p><p><strong>Conclusion: </strong>The collaborative telepharmacy circuit was efficiently and safely implemented, offering an innovative approach that meets the needs and expectations of patients in the OPCU.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women and adverse drug reactions: 56 years of analysis of real-world data collected in the FDA adverse event reporting system (FAERS) database.","authors":"Eleonora Castellana, M A Chiappetta","doi":"10.1136/ejhpharm-2025-004597","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004597","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological resilience in the context of geopolitical tensions: a European perspective.","authors":"Eduardo Tejedor-Tejada, Iván Cores-Rodríguez, Carlos José Cortes Sánchez","doi":"10.1136/ejhpharm-2025-004587","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004587","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling medication errors: how a systems approach improves patient safety.","authors":"Sonja Guntschnig, Renata Barbosa, Helena Jenzer, Matthew Greening, Jennifer Hayde, Helen Heery, Maria Cristina Iglesias Serrano, Kristína Lajtmanová, Elisabetta Rossin, Slagjana Tentova-Peceva, Stephanie Kohl, Alma Mulac","doi":"10.1136/ejhpharm-2025-004533","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004533","url":null,"abstract":"<p><strong>Objectives: </strong>Medication errors are a leading source of preventable harm in healthcare, affecting approximately 1 in 30 patients, with a substantial proportion resulting in severe outcomes. In response, the European Association of Hospital Pharmacists convened a Special Interest Group (SIG) to propose comprehensive and sustainable strategies for reducing these errors across Europe, employing a systems approach.</p><p><strong>Methods: </strong>89 anonymised medication error reports, and empirical data from the SIG members' daily practice, were analysed to identify root causes, classified into system-level and individual errors. Expert subgroups then linked root causes to targeted preventive measures. A literature review was conducted, searching PubMed and Embase databases, to assess existing standards and identify gaps in medication safety practices, which informed the analysis.</p><p><strong>Results: </strong>Analysis revealed that governance deficiencies and inconsistent implementation of existing legal standards contribute significantly to medication errors. System-level issues, including inadequate oversight, understaffing and insufficient technical infrastructures, along with individual errors from cognitive lapses, were prevalent. The literature review supported these findings and highlighted the variability in medication safety practices across systems, underscoring the importance of strategic improvements in healthcare policies.</p><p><strong>Conclusions: </strong>Findings highlight the critical need for robust governance, comprehensive policy frameworks and enhanced safety cultures to prevent medication errors. Automation and improved human-machine interfaces are recommended to mitigate active failures and enhance system reliability. This systems-thinking approach, supported by strengthening legislation and better resource allocation, is essential for reducing medication errors and improving patient safety.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of pharmaceutical infusion management to reduce incompatibilities and fluid overload: a retrospective observational study in a paediatric intensive care unit.","authors":"Mona Kleinlein, Karin Stuebinger, Michael Hoeckel, Martina Patrizia Neininger, Thilo Bertsche","doi":"10.1136/ejhpharm-2025-004492","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004492","url":null,"abstract":"<p><strong>Introduction: </strong>Fluid overload is associated with increased morbidity in patients in paediatric intensive care units (PICUs). This study aimed to evaluate pharmaceutical infusion management as a quality assurance measure to reduce fluid overload in routine paediatric intensive care.</p><p><strong>Methods: </strong>This was a retrospective observational study in a PICU with two periods: a control period and a period after the implementation of pharmaceutical infusion management (PharmInfuManagement period). Pharmaceutical infusion management consisted of two components carried out simultaneously: the creation of flushing schedules to reduce incompatibilities and flushing volume and the reduction of dilution volume for six non-continuous intravenous (IV) drugs to reduce fluid intake because of IV drugs. The primary outcome was the number of patients with ≥5% fluid overload. In addition, daily furosemide dose (mg/kg/day), non-continuous IV drug volume (mL/kg/day), flushing volume (mL/kg/day) and number of incompatibilities were evaluated.</p><p><strong>Results: </strong>Sixty-six patients were included in each period. Fluid overload of ≥5% occurred in 52% of patients in the control period and in 29% of patients in the PharmInfuManagement period (p=0.01). Flushing volume decreased from 0.7 mL/kg/day (median Q25/Q75 0.4/1.4) to 0.3 mL/kg/day (median Q25/Q75 0.1/0.7) (p<0.001) after implementation. During the PharmInfuManagement period, potentially incompatible drug combinations were reduced from 17.1% (86/504) to 8.2% (43/523) (p<0.001). The volume required for reconstitution and dilution of non-continuously administered IV drugs was reduced from 8.8 mL/kg/day (median Q25/Q75 7.1/12.6) to 6.8 mL/kg/day (median Q25/Q75 5.5/8.0) (p=0.02).</p><p><strong>Conclusion: </strong>Pharmaceutical infusion management reduces incompatibilities and fluid overload in PICU patients.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of authorship integrity in scientific publications within healthcare and hospital pharmacy.","authors":"Eleonora Castellana","doi":"10.1136/ejhpharm-2024-004409","DOIUrl":"10.1136/ejhpharm-2024-004409","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":"197-198"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacy as a guarantee of safety in times of crisis: evolution and relevance of the continued presence of clinical pharmacists in frontline medical units during the first wave of COVID-19.","authors":"Arnaud Tanty, Elisa Vitale, Dorothée Lombardo-Duron, Armance Grevy, Prudence Gibert, Claire Chapuis, Christine Chevallier-Brilloit, Benoît Allenet, Pierrick Bedouch, Sebastien Chanoine","doi":"10.1136/ejhpharm-2023-003815","DOIUrl":"10.1136/ejhpharm-2023-003815","url":null,"abstract":"<p><p>BackgroundThe COVID-19 pandemic has had a major impact on the organisation of health services worldwide. In the first wave, many therapeutic options were explored, exposing patients to significant iatrogenic risk. In a context in which patient management was not well defined by clear recommendations and in which healthcare professionals were under great stress, was it still relevant to maintain pharmaceutical care or did it bring an additional factor of disorganisation?</p><p><strong>Objective: </strong>The aim of our study was to compare the relevance of pharmaceutical care practices before and during the COVID-19 crisis.</p><p><strong>Methods: </strong>A retrospective, comparative, observational analysis was conducted in two medical units in a French university hospital that were receiving patients with COVID-19 and benefiting from pharmaceutical care prior to the crisis. This study compared clinical pharmacy performance between two 1.5-month periods before and during the COVID-19 crisis. Performance was assessed according to the CLEO scale, rating the clinical, economic and organisational impacts of the accepted pharmaceutical interventions (PIs) performed in these units.</p><p><strong>Results: </strong>Of the 675 accepted PIs carried out in the two medical units over the entire study period, PIs performed during the COVID-19 period had a greater significant clinical impact (72% vs 56%, p˂0.0001), a more positive economic impact (38% vs 23%, p˂0.0001) and a more favourable organisational impact (52% vs 20%, p˂0.0001) than those performed prior to the COVID-19 period.</p><p><strong>Conclusions: </strong>The health crisis generated important changes in care practices. Our study demonstrates the sustained relevance of pharmaceutical care during a health crisis. This local experience confirms the major interest in improving the integration of pharmaceutical expertise within French healthcare teams.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":"226-231"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital pharmacists in antimicrobial stewardship programmes: a call for harmonised action across Europe.","authors":"Daniele Mengato, Paul van der Linden, Giacomo Berti, Elisa Barbieri, Reinier M Van Hest, Daniele Donà","doi":"10.1136/ejhpharm-2024-004423","DOIUrl":"https://doi.org/10.1136/ejhpharm-2024-004423","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":"32 3","pages":"199-201"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}