European journal of hospital pharmacy : science and practice最新文献

{"title":"Antibiotic labels frozen in time: a barrier to effective antimicrobial stewardship?","authors":"Daniele Mengato, Xhoajda Taci, Elisabetta Mariavittoria Giunco, Samuele Gardin, Silvia Cavinato, Sonia Faoro, Umberto Gallo, Annamaria Cattelan, Francesca Venturini","doi":"10.1136/ejhpharm-2025-004760","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004760","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication needs of children and young people for successful transition to adult services (the SUCCESS study): an exploratory cross-sectional observational study.","authors":"Ashifa Trivedi, Sarah Mohamad, Merin Thoppil, Roshnee Patel, Shivani Sethi, Naiya Patel, Anne-Lise Goddings","doi":"10.1136/ejhpharm-2025-004528","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004528","url":null,"abstract":"<p><strong>Objective: </strong>To explore the medication-related knowledge, behaviours and support needs of children and young people (YP) aged 11-16 years with long-term conditions as they prepare to transition from paediatric to adult healthcare services.</p><p><strong>Methods: </strong>This exploratory cross-sectional study was co-designed with YP living with chronic conditions, conducted at a district general hospital in Northwest London between April and September 2023. Participants were those aged 11-16 years admitted to the paediatric ward with long-term conditions requiring regular medication. YP self-completed a questionnaire on medication-related aspects of transition, including knowledge of medication names, dosages, reordering, side effects, adherence and their ability to manage medications independently.</p><p><strong>Results: </strong>Of 41 eligible YP, 30 completed the questionnaire (73% response rate). Most knew the names and dosages of their medications (24/30) and why they were prescribed (25/30). However, only half (15) knew how their medicines worked, and fewer (10) were aware of potential side effects. Just 12 participants knew how to reorder their medication. Fifteen reported missing doses, mostly due to forgetfulness. Most relied on parents or carers to manage medicines (23), with only four managing independently. YP reported healthcare professionals (17) and family (19) as their main sources of medication information.</p><p><strong>Conclusions: </strong>This study suggests that while YP often have good foundational medication knowledge, many lack the deeper understanding and practical skills required for independent self-management. Knowledge of side effects, reordering processes and shared decision-making was limited, areas which could undermine transition readiness if unaddressed. Pharmacists, working as part of the multidisciplinary team, are well placed to support YP through targeted, age-appropriate education and regular review.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical role of persistence and adherence in multiple sclerosis treatment: the value of cladribine.","authors":"Joaquin Borrás Blasco, Vicente Merino-Bohorquez, Esther Ramírez Herráiz","doi":"10.1136/ejhpharm-2025-004582","DOIUrl":"10.1136/ejhpharm-2025-004582","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of off-label dupilumab use for the treatment of pemphigoid gestationis: a new case report.","authors":"María Calvo Arbeloa, Amaya Arrondo Velasco, Paula Rodriguez Jimenez, Maite Sarobe Carricas","doi":"10.1136/ejhpharm-2025-004583","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004583","url":null,"abstract":"<p><p>Pemphigoid gestationis (PG) is a very rare autoimmune disorder that typically occurs during the second and third trimesters of pregnancy. It is characterised by intense pruritus, erythematous plaques and vesicles, primarily affecting the abdomen and extremities. The exact cause remains unclear, but type 2 inflammation and antibodies against the collagen protein BP180 are implicated. Diagnosis is confirmed through clinical findings and specific tests. Traditional treatments include topical and systemic corticosteroids, but they can have significant side effects.This case report discusses a 38-year-old woman with PG in her second pregnancy, who experienced the disorder in her first pregnancy with severe symptoms and was treated with corticosteroids and intravenous immunoglobulins but developed serious side effects. In her current pregnancy, dupilumab was introduced at week 30 (off-label use), leading to significant symptom improvement within a week.This case supports the potential of dupilumab as a first-line treatment for severe PG, demonstrating safety and efficacy for both mother and baby.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ifosfamide-induced encephalopathy and concomitant use of netupitant/palonosetron in a patient with soft tissue sarcoma: a case report.","authors":"Andrea Pinilla Rello, Rafael Huarte Lacunza, Antonio Tejada Artigas","doi":"10.1136/ejhpharm-2025-004493","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004493","url":null,"abstract":"<p><p>A woman in her 30s diagnosed with high-grade soft tissue sarcoma with pulmonary metastases began treatment with ifosfamide-epirubicin, netupitant/palonosetron and dexamethasone. Shortly after, she developed dizziness and dysarthria, raising suspicion of ifosfamide-induced encephalopathy. Ifosfamide was immediately discontinued before the first dose was completed, and treatment with methylene blue was initiated the following day as the clinical condition continued to worsen. Due to her clinical condition, she was transferred to the intensive care unit, where she was started on thiamine and dexmedetomidine combined with methylene blue. Three days later, her neurological status improved, allowing methylene blue and thiamine to be discontinued. Several publications have reported cases of ifosfamide-related encephalopathy in patients receiving concomitant aprepitant, a CYP3A4 substrate and inhibitor that may increase the levels of ifosfamide's toxic metabolites. However, no cases of ifosfamide-induced encephalopathy have been reported with the use of netupitant/palonosetron for antiemetic prophylaxis. In light of our patient's condition, it is possible that the concomitant use of ifosfamide and netupitant/palonosetron contributed to an earlier onset and increased severity of ifosfamide-related neurotoxicity.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-led stewardship standardised broad-spectrum antibiotic use in a geriatric-heavy neurology ward.","authors":"Qinbo Chen, Li Zhang","doi":"10.1136/ejhpharm-2025-004630","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004630","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of clinical pharmacist-led antibiotic stewardship on enhancing the rational use of antibiotics in a geriatric-heavy neurology ward.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on all antibiotic-treated hospitalised cases during the study period, with a total of 123 patients. The study employed a consecutive enrolment design. Of these, 62 cases were managed under a pharmacist-led antibiotic stewardship programme as the intervention group, while the remaining 61 cases served as controls. Primary outcomes included hospitalisation stays, hospitalisation costs, antibiotic consumption, the duration of antibiotic use and the efficacy of antibiotic therapy.</p><p><strong>Results: </strong>The intervention group exhibited a lower number of defined daily doses (DDDs) per patient between their stay compared with the control group (13.18±1.25 DDDs vs 20.03±2.15 DDDs, p=0.007). Moreover, the duration of single antibiotic treatment was notably reduced in the intervention group (10.40±0.75 days vs 13.16±1.16 days, p=0.047), as was the duration of the single longest empirical therapy with broad-spectrum antibiotics (6.77±0.55 days vs 10.29±1.15 days, p=0.007).</p><p><strong>Conclusions: </strong>Pharmacist-led antibiotic stewardship effectively optimised antibiotic use in geriatric neurology patients, reducing unnecessary broad-spectrum antibiotic exposure and improving treatment efficiency.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxifloxacin-induced insomnia with psychotic episodes in a toddler: a case report.","authors":"Violeta Getova-Kolarova, Ines Hababa-Ivanova, Nicoleta Georgieva","doi":"10.1136/ejhpharm-2025-004600","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004600","url":null,"abstract":"<p><p>Moxifloxacin is a fourth-generation fluoroquinolone with a broad spectrum of antibacterial activity. It is commonly used for both local and systemic applications. Data on the safety profile of fluoroquinolones indicate the potential for serious adverse reactions including neurological and psychiatric disturbances. The current case describes the off-label use of moxifloxacin eye drops for nasal administration in a toddler which led to insomnia and symptoms of severe psychosis. Notably, these adverse events resolved completely shortly after discontinuation of treatment. This case highlights a rare and potentially debilitating adverse reaction and underscores the critical importance of clinical judgement when prescribing off-label medicines in the paediatric population.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unused medication among outpatients receiving cost-free medication from a community pharmacy in the Region of Southern Denmark.","authors":"Thomas Croft Buck, Mia Lolk Lund","doi":"10.1136/ejhpharm-2025-004615","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004615","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the extent and nature of unused medication dispensed from the hospital as cost-free medication (CFM), sent to and collected from the community pharmacy (St Thomas Pharmacy) in the Region of Southern Denmark.</p><p><strong>Methods: </strong>This observational study was conducted over 6 months. In the first 2 months, patients collecting CFM were invited to participate in an unused medication monitoring programme by completing an inclusion questionnaire. Those who consented were followed for four additional months and asked to report on unused medication during subsequent visits. Data on dispensed medication and patient-reported unused medication were collected using structured survey forms and analysed using descriptive statistics.</p><p><strong>Results: </strong>Thirteen per cent of patients reported unused medication from approximately 100 enrolled participants. Collecting CFM for themselves, the unused medication rate was 15%, compared with 8% among those collecting on behalf of others. No unused medication was reported by first-time collectors. Reported reasons included clinical changes (eg, dose adjustments, treatment discontinuation, adverse effects) and administrative errors (eg, excess quantities, incorrect formulations). The total value of unused medication was estimated at 83 000 Kr (€11 100). Extrapolated to the annual distribution volume at the St Thomas Pharmacy, the annual loss from unused medication would be 900 000 Kr (€120 000).</p><p><strong>Conclusion: </strong>The small sample size in this project is a limitation and associated with an uncertain outcome. Unused medication related to CFM is a measurable and economically significant issue, primarily driven by clinical and administrative factors. While reducing pack sizes could help mitigate unused medication, this may increase logistical burdens on patients and healthcare providers. A larger distribution model, such as dispensing through all local community pharmacies under hospital tender agreements, may offer a more efficient solution but would require legislative reform. Broader, multi-site studies are needed to validate findings and inform future policy interventions.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing depression management in older cancer patients: the pharmacist's role.","authors":"Rojita Jadhari, Nabin Pathak, Shreya Dhungana, Ajaya Acharya, Sunil Shrestha","doi":"10.1136/ejhpharm-2025-004682","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004682","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital pharmacists in cardio-oncology: bridging a critical gap in multidisciplinary cancer care.","authors":"Esteban Zavaleta-Monestel, Sebastian Arguedas-Chacon, Kevin Cruz-Mora, Jeaustin Mora-Jimenez","doi":"10.1136/ejhpharm-2025-004698","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004698","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}