Sylvain Auvity, Franck Bienvenot, Flavien Pallard, Nadir Mammar, Valentine Famelart, Jeremie Rudant, Nicolas Cormier
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Organisational impact of in vivo gene therapies at two French injection centres.
Objectives: The aim of this study was to estimate the main hospital organisational impacts of in vivo gene therapy medicine (GTM) deployment, experienced during clinical trials, with a focus on hospital pharmacy.
Methods: Interviews were performed with 11 healthcare professionals involved in three clinical trials, as was an active field observation.
Results: Interviews showed high impact for the management of hospital beds and human resources. Moderate impact concerned facilities/equipment, coordination between stakeholders and training/software. The total cumulative working time of the pharmacy staff, estimated at 11.12 and 11.67 hours in the two centres for a single GTM, has been identified as the main limiting factor for the pharmacy.
Conclusions: This study showed that major organisational impacts of in vivo GTMs in injection centres concern hospital bed and pharmaceutical staff management, rather than technical and operational aspects. Overall, no more than 150 GTMs could be prepared each year by one pharmacist and one technician.
期刊介绍：
European Journal of Hospital Pharmacy (EJHP) offers a high quality, peer-reviewed platform for the publication of practical and innovative research which aims to strengthen the profile and professional status of hospital pharmacists. EJHP is committed to being the leading journal on all aspects of hospital pharmacy, thereby advancing the science, practice and profession of hospital pharmacy. The journal aims to become a major source for education and inspiration to improve practice and the standard of patient care in hospitals and related institutions worldwide.
EJHP is the only official journal of the European Association of Hospital Pharmacists.
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