European journal of physical and rehabilitation medicine最新文献

{"title":"Graph modeling of relational structures among functioning variables with low back pain: an exploratory analysis based on International Classification of Functioning, Disability and Health.","authors":"Zi-Yan Zhu, Hui-Hui Shan, Jin Wang, Hong-Jun Zhu, Shou-Guo Liu, Feng Lin","doi":"10.23736/S1973-9087.24.08089-4","DOIUrl":"10.23736/S1973-9087.24.08089-4","url":null,"abstract":"<p><strong>Background: </strong>Given the complex etiology, multidimensional impact, and widespread prevalence of low back pain (LBP), it is crucial to prioritize intervention targets based on understanding the relationships between functional impairments in patients. This prioritization maximizes the physical and psychological benefits for patients, and graph modeling holds promise in achieving these objectives.</p><p><strong>Aim: </strong>The aim of this study was establishing a graphical model of functioning variables for LBP based on the International Classification of Functioning, Disability, and Health (ICF) to identify the most influential items (i.e., functioning variables) on the physical and mental well-being of patients. Exploring feasible intervention measures by understanding the dysfunction correlations among these variables.</p><p><strong>Design: </strong>Cross-sectional survey.</p><p><strong>Setting: </strong>Nine hospitals in Jiangsu Province, China.</p><p><strong>Population: </strong>Three hundred and six persons with LBP aged ≥18 years.</p><p><strong>Methods: </strong>All patients were assessed using the Comprehensive ICF Core Sets for LBP. The scoring system was converted to dichotomous data, with 1 indicating dysfunction and 0 indicating no dysfunction. In the graphical model, network parameters and the results of Item Response Theory modeling (as detailed in our other article) were used to determine the importance of items, while partial correlations were utilized to estimate the dysfunction correlations between functioning variables.</p><p><strong>Results: </strong>1) A total of 56 ICF items were located in the backbone structure of LBP, among which d430 (Lifting and carrying objects) occupied the most central position, followed by b126 (Temperament and personality functions). 2) In the main component of backbone structure, d430 has moderate dysfunction correlation with looking after one's health (0.6027), social norms, practices and ideologies (0.597), stability of joint functions (0.5759), and emotional functions (0.4078). b126 has moderate dysfunction correlation with basic interpersonal interactions (0.6595).</p><p><strong>Conclusions: </strong>d430 and b126 significantly impact the physical and mental well-being of LBP patients. To improve d430, maintaining exercise habits, reducing working hours, enhancing lumbar stability, and overcoming fear-related emotions are recommended. Similarly, improving b126 can be achieved through enhancing interpersonal relationships.</p><p><strong>Clinical rehabilitation impact: </strong>Through the identification of crucial functioning variables and the associated dysfunctional correlation relationships, graphical model of Comprehensive ICF Core Set for LBP can offer healthcare decision-makers valuable insights into potential treatment targets and pathways aimed at improving the condition of LBP patients.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"487-495"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and clinical characteristics associated with failure of physical therapy in chronic low back pain: a secondary analysis from a randomized controlled trial.","authors":"Yong-Hui Zhang, Meng-Si Peng, Rui Wang, Yi-Zu Wang, Chang-Cheng Chen, Juan Wang, Yi-Li Zheng, Hao-Ran Xu, Pei-Jie Chen, Xue-Qiang Wang","doi":"10.23736/S1973-9087.24.08033-X","DOIUrl":"10.23736/S1973-9087.24.08033-X","url":null,"abstract":"<p><strong>Background: </strong>The effect of physical therapy on pain and disability alleviation in patients with chronic low back pain (cLBP) has been demonstrated, but the risk factors for treatment failure remain unknown.</p><p><strong>Aim: </strong>To explore the associations of baseline demographic and clinical characteristics with treatment failure after physical therapy intervention for cLBP.</p><p><strong>Design: </strong>A secondary analysis of a single-blind randomized clinical trial.</p><p><strong>Setting: </strong>A rehabilitation hospital.</p><p><strong>Population: </strong>A total of 98 patients with cLBP completed the 12-month measurement.</p><p><strong>Methods: </strong>Patients were randomly grouped into 3-month therapeutic aquatic exercise or physical therapy modalities. The primary outcome was treatment failure, which was defined as a decrease in the numeric rating scale to less than 2.0 points at 12-month follow-up. Associations between baseline demographic and clinical characteristics with risk of treatment failure were assessed by logistic regressions.</p><p><strong>Results: </strong>The pain intensity in the failure cases was alleviated after 3-month intervention but continuously increased at 6- and 12-month follow-up (P<0.05). Old age was significantly associated with an increased risk of treatment failure (adjusted OR 3.26, 95% CI 1.11-9.60). Compared with those receiving physical therapy modalities, the patients receiving therapeutic aquatic exercise had less risk of treatment failure (adjusted OR 0.19, 95% CI 0.08-0.47), and age (P=0.022) was a modifier for this association.</p><p><strong>Conclusions: </strong>Compared with younger ones, older patients with cLBP had a higher risk of treatment failure after physical therapy and gained a stronger benefit of long-term pain alleviation from therapeutic aquatic exercise.</p><p><strong>Clinical rehabilitation impact: </strong>Therapeutic aquatic exercise is an effective therapy for cLBP and more helpful for preventing treatment failure than physical therapy modalities, especially for older patients.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"477-486"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dog-assisted physiotherapy in amyotrophic lateral sclerosis: a randomized controlled pilot study.","authors":"Manuela Vignolo, Riccardo Zuccarino, Romina Truffelli, Chiara Gemelli, Elisa Giove, Pilar M Ferraro, Davide Manunza, Clotilde Trinchero, Iacopo Cipollina, Mirela Lungu, Andrea Lizio, Gaia Gragnano, Corrado Cabona, Matteo Pardini, Claudia Caponnetto, Fabrizio Rao","doi":"10.23736/S1973-9087.24.08343-6","DOIUrl":"10.23736/S1973-9087.24.08343-6","url":null,"abstract":"<p><strong>Background: </strong>Animal-assisted therapy (AAT) is an intervention in which the animal acts as a co-therapist. It has been mainly used in the context of patients with dementia, showing positive effects on psychological symptoms, but its potential as a physiotherapy treatment for patients with neuromuscular disorders, amyotrophic lateral sclerosis (ALS) in particular, has not yet been investigated.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the impact of AAT, specifically of dog-assisted therapy, on motor functions and psychological status in patients with ALS.</p><p><strong>Design: </strong>This study was a randomized controlled pilot study.</p><p><strong>Setting: </strong>The study was carried out at the Rehabilitation Unit NEuroMuscular Omnicenter (NEMO) of Arenzano, Genoa.</p><p><strong>Population: </strong>Sixty hospitalized ALS patients were enrolled.</p><p><strong>Methods: </strong>All patients ran a regular two-weeks neurorehabilitation program twice a day. For three days a week, in place of the morning traditional treatment, the AAT group performed a rehabilitation session with a simultaneous interaction with the therapy-dog, while the control group performed a traditional rehabilitation session. The outcome measures were the Timed Up and Go Test, the Short Physical Performance Battery (SPPB), the Six Minutes Walk Test, the Ten Meters walking Test and the Hospital Anxiety and Depression Scale.</p><p><strong>Results: </strong>Both groups showed an amelioration in motor scales. However, SPPB subscales as well as HADS scores showed a statistically significant improvement only in the AAT group (P values from <0.0001 to 0.0004). Additionally, across almost all motor and psychological measures, post-treatments values were significantly better for the AAT group (P values from <0.0001 to 0.01).</p><p><strong>Conclusions: </strong>The obtained results not only suggest that AAT is comparable to traditional physiotherapy treatments, but also evidence that this type of treatment has greater beneficial effects on motor and psychological symptoms in patients with ALS.</p><p><strong>Clinical rehabilitation impact: </strong>This study provides first evidence that AAT is a powerful rehabilitation strategy in patients with ALS, improving both motor and psychological symptoms, and therefore possibly ameliorating quality of life.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"470-476"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators for increased accessibility to quality rehabilitation services in low- and middle- income countries: a systematic review.","authors":"Ohnmar Htwe, Brenda S Yuliawiratman, Abena Y Tannor, Muhamad Z Nor Asikin, Elaine Soh, Wouter DE Groote, Manimalar S Naicker, Amaramalar S Naicker","doi":"10.23736/S1973-9087.24.08154-1","DOIUrl":"10.23736/S1973-9087.24.08154-1","url":null,"abstract":"<p><strong>Introduction: </strong>With an increasing number of people experiencing limitations in functioning during their life course, the need for comprehensive rehabilitation services is high. In 2017, the WHO Rehabilitation 2030 initiative noted that the need for the establishment and expansion of rehabilitation services is paramount in order to obtain well-being for the population and to ensure equal access to quality healthcare for all. The organization of rehabilitation services is however facing challenges especially in low-and middle-income countries with a very small proportion of people who require rehabilitation actually getting them. Various surveys conducted in low-and -middle income countries have revealed existing gaps between the need for rehabilitation services and the actual receipt of these services. This systematic review aimed to determine the barriers and facilitators for increasing accessibility to rehabilitation services in low- and middle-income countries. Recommendations for strengthening rehabilitation service organization are presented based on the available retrieved data.</p><p><strong>Evidence acquisition: </strong>In this systematic review, an electronic search through three primary databases, including Medline (PubMed), Scopus and Web of Science (WOS) was conducted to identify original studies reporting on barriers and facilitators for rehabilitation service organization in low-and middle-income countries. Date of search: 25^th April 2021 (PubMed), 3^rd May 2021 (Scopus and Web of Science). All studies including barriers or/and facilitators for rehabilitation services in low- and middle income countries which were written in English were included in the review. The articles written in other languages and grey literature, were excluded from this review.</p><p><strong>Evidence synthesis: </strong>Total of 42 articles were included from year 1989 to 2021. Numerous barriers were identified that related to education, resources, leadership, policy, technology and advanced treatment, community-based rehabilitation (CBR), social support, cultural influences, political issues, registries and standards of care. National health insurance including rehabilitation and funding from government and NGOs are some of the facilitators to strengthen rehabilitation service organization. Availability of CBR programs, academic rehabilitation training programs for allied health professionals, collaboration between Ministry of Heath (MOH) and Non-governmental Organizations (NGOs) on telerehabilitation services are amongst other facilitators.</p><p><strong>Conclusions: </strong>Recommendations for improving and expanding rehabilitation service organization include funding, training, education, and sharing of resources.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"514-522"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadriceps femoris muscle ultrasound in sarcoidosis: an observational case-control study.","authors":"Rana Terlemez, Buket Caliskaner Ozturk, Sevgi S Kurtoglu, Deniz Palamar, Ersan Atahan, Kenan Akgun","doi":"10.23736/S1973-9087.24.08232-7","DOIUrl":"10.23736/S1973-9087.24.08232-7","url":null,"abstract":"<p><strong>Background: </strong>Although loss of muscle mass may be associated with general weakness, intolerance to physical activity and fatigue, it is underestimated and poorly understood in patients with sarcoidosis.</p><p><strong>Aim: </strong>To compare the quadriceps femoris muscle (QFM) thickness measured by ultrasonography (US) between the female patients with sarcoidosis and controls, secondly to assess the correlation between the muscle strength, fatigue and QFM thickness.</p><p><strong>Design: </strong>Observational, case-control study.</p><p><strong>Setting: </strong>Physical Medicine and Rehabilitation Department of a University Hospital.</p><p><strong>Population: </strong>Thirty-one women with sarcoidosis and 27 healthy volunteers were included in the study.</p><p><strong>Methods: </strong>The participants were evaluated for the following outcomes: 1) handgrip strength; 2) QFM thickness measured using US; and 3) sonographic thigh adjustment ratio (STAR). The sarcoidosis group was also evaluated with the 30-second chair stand test (30s-CST) and Fatigue Severity Scale (FSS).</p><p><strong>Results: </strong>The QFM thickness and STAR values of the patients with sarcoidosis were significantly lower than those of the controls (P=0.0001). However, no statistically significant difference was observed between the handgrip strengths of the groups (P=0.581). There was no statistically significant correlation between the STAR values and handgrip strength in the sarcoidosis group; however, there was a significant positive correlation between the STAR values and 30s-CST (r=0.467, P=0.008).</p><p><strong>Conclusions: </strong>Loss of muscle mass is one of the musculoskeletal conditions in patients with sarcoidosis that may be associated with nonspecific symptoms, such as general debility, intolerance to physical activity, and fatigue. In the present study, no difference was observed in hand grip strength between the groups, while we found that QFM thickness was affected in patients with sarcoidosis when compared to the controls. The ultrasonographic QFM evaluation seems to be an innovative tool which may be used at all stages of sarcoidosis patient follow-up.</p><p><strong>Clinical rehabilitation impact: </strong>The grip strength is a commonly used test to detect muscle weakness, but onset of a decrease in muscle mass in the lower extremities may occur earlier. Considering the increased burden of musculoskeletal problems in this population, performing 30s-CST and sonographic QFM thickness is practical methods to identify risky patients.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"523-529"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive approaches in the rehabilitation of upper limbs function in children with cerebral palsy: a systematic review and meta-analysis.","authors":"Andrea Demeco, Anna Molinaro, Martina Ambroggi, Antonio Frizziero, Elisa Fazzi, Cosimo Costantino, Giovanni Buccino","doi":"10.23736/S1973-9087.24.08288-1","DOIUrl":"10.23736/S1973-9087.24.08288-1","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral palsy (CP) is the predominant cause of children disability. It is characterized by motor, sensory, and postural deficits due to a non-progressive injury to the developing central nervous system. In recent years, new rehabilitation techniques targeting the central representations of motor patterns have been introduced: the most used are action observation therapy (AOT), motor imagery (MI), and mirror therapy (MT). Aim of this study is to assess the effectiveness of these cognitive strategies on the recovery of upper limb motor functions in children with CP.</p><p><strong>Evidence acquisition: </strong>This study was designed as a systematic review and meta-analysis, registered in PROSPERO (CRD42023403794). For the report and methodological definitions of this study, the recommendations of the PRISMA protocol and the Cochrane collaboration, were followed. A total of 3 electronic databases (PubMed, Scopus, and Web of Science) were searched for relevant Randomized Control Trials (RCT) using the combinations of terms \"cerebral palsy\" AND \"action observation\" OR \"motor imagery\" OR \"mirror therapy\" OR \"cognitive therapy.\" A meta-analysis was carried out to compare cognitive and conventional approaches and combine direct and indirect effects. A random-effects meta-analysis model was used to derive pooled effect estimates.</p><p><strong>Evidence synthesis: </strong>Out of 328 records, 12 RCTs were analyzed in this systematic review published from 2012 to 2022, and included 375 children, of whom 195 received cognitive therapies, and 180 underwent conventional rehabilitation. AOT was the most investigated (RCTs N.=7), and showed significant results in the recovery of upper limb motor functions, albeit the meta-analysis demonstrated a non-significant difference in Melbourne Unilateral Upper limb Scale (MUUL) (95% CI: -7.34, 12); in Assisting Hand Assessment (AHA) (95% CI: -4.84, 10.74), and in AbilHand-Kids Questionnaire (95% CI: -1.12, 1.45). Five RCTs investigated MT showing significant improvements in grip and dexterity; none used MI as intervention therapy.</p><p><strong>Conclusions: </strong>Cognitive therapies provided with encouraging results in the recovery of upper limb motor functions, although not a clinical effect in bimanual or unimanual performance; they could represent a valid therapeutic solution integrated to conventional rehabilitation in the treatment of upper limb motor impairment in children with CP.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"445-457"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-rehabilitation for cognitive home-based treatment in young traumatic brain injury: a pilot study.","authors":"Federica Bertolucci, Loredana Fossati, Barbara Agostini, Chiara Malasoma, Giuseppina Sgandurra, Benedetta Del Lucchese, Mario Miccoli, Federico Posteraro","doi":"10.23736/S1973-9087.24.08379-5","DOIUrl":"10.23736/S1973-9087.24.08379-5","url":null,"abstract":"","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"420-422"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Intensive bracing management combined with physiotherapeutic scoliosis-specific exercises for adolescent idiopathic scoliosis patients with a major curve ranging from 40-60° who refused surgery: a prospective cohort study\".","authors":"Tuğba Kuru Çolak, Burçin Akçay, Elif Elçin Dereli, İlker Çolak","doi":"10.23736/S1973-9087.24.08395-3","DOIUrl":"10.23736/S1973-9087.24.08395-3","url":null,"abstract":"","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":"60 3","pages":"544-545"},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11258904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-polio syndrome is not a dysimmune condition.","authors":"Isabelle Laffont, Claire Duflos, Christophe Hirtz, Karima Bakhti, Anthony Gelis, Claire Palayer, Valérie Macioce, Marion Soler, Fanny Pradalier, Florence Galtier, Alexandre Jentzer, Claire Lozano, Thierry Vincent, Raul J Morales","doi":"10.23736/S1973-9087.23.08158-3","DOIUrl":"10.23736/S1973-9087.23.08158-3","url":null,"abstract":"<p><strong>Background: </strong>Poliomyelitis is a global disabling disease affecting 12-20 million of people. Post poliomyelitis syndrome (PPS) may affect up to 80% of polio survivors: increased muscle weakness, pain, fatigue, functional decline. It relies on aging of an impaired neuro-muscular system with ongoing denervation processes. A late involvement of humoral or cellular pro-inflammatory phenomena is also suspected.</p><p><strong>Aim: </strong>To assess the dysimmune hypothesis of PPS by comparing lymphocyte subpopulations and humoral immune factors between PPS patients and controls.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Montpellier University Hospital.</p><p><strong>Population: </strong>Forty-seven PPS and 27 healthy controls.</p><p><strong>Methods: </strong>PPS patients and controls were compared on their lymphocyte subpopulations and humoral immune factors (IL-1β, IL-6, IL-8, IL-17, IL-21, IL-22, IL-23, IFN-γ, TNF-α, GM-CSF, RANTES, MCP1, MIP-3a, IL-10, TGF-β, IL4, IL13). Patients were further compared according to their dominant clinical symptoms. Sample size guaranteed a power >90% for all comparisons.</p><p><strong>Results: </strong>PPS patients and controls were comparable in gender, age and corpulence. Most patients had lower limb motor sequelae (N.=45, 95.7%), a minority had upper limb motor impairment (N.=16, 34.0%). Forty-five were able to walk (94%), 35/45 with technical aids. The median of the two-minute walking test was 110 meters (interquartile range 55; 132). Eighteen (38%) required help in their daily life. Their quality of life was low (SF36). All described an increased muscular weakness, 40 (85%) a general fatigue, and 39 (83%) muscular or joint pain. Blood count, serum electrolytes, T and B lymphocyte subpopulations and cytokines were comparable between patients and controls, except for creatine phospho kinase that was significantly higher in PPS patients. None of these variables differed between the 20/47 patients whose late main symptoms were pain or fatigue, and other patients.</p><p><strong>Conclusions: </strong>Our results suggest that PPS is not a dysimmune disease.</p><p><strong>Clinical rehabilitation impact: </strong>Our results do not sustain immunotherapy for PPS. Our work suggest that PPS may be mostly linked to physiological age-related phenomena in a disabled neuromuscular condition. Thus, our results emphasize the role of prevention and elimination of aggravating factors to avoid late functional worsening, and the importance of rehabilitation programs that should be adapted to patients' specific conditions.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"270-279"},"PeriodicalIF":4.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11112507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and Rehabilitation Medicine: say relational or functional, not holistic.","authors":"Luigi Tesio, Stefano Scarano, Antonio Caronni","doi":"10.23736/S1973-9087.24.08309-6","DOIUrl":"10.23736/S1973-9087.24.08309-6","url":null,"abstract":"<p><p>Modern medicine tends to privilege disciplines promising \"objective\" laws governing body parts (from molecules to organs). Studies on a person's illness and disability are (apparently) confined to \"subjectivity.\" The Specialty of Physical and Rehabilitation Medicine is often regarded as a humanitarian approach, belonging at best to the family of \"soft,\" \"qualitative,\" or \"quasi-experimental\" sciences. This specialty often claims specificity by labelling itself as \"functional\" and \"holistic.\" However, it is shown here that the former term is acceptable, yet redundant, and the second misleading. When human behaviors and perceptions are at stake, \"function\" indicates a person's relationship with the outer world (already tackled by the definitional term \"physical\" from the Greek \"physis\"). The word \"holistic\" emphasizes mind-body unity and person-environment interdependence but, in current usage, overshadows the complementary need for an analytic, experimental approach to any function. Medicine aims at fighting disease and disability in single persons. This endeavor requires knowing body parts and mechanisms and understanding how interventions on \"parts\" affect the \"whole.\" This understanding rests on the experimental method. For instance, returning to a given societal role (participation) may require restoration of walking (activity), which may require reinforcement of weakened muscular groups (impairment). Working only on holistic bio-psycho-social \"wholes\" may miss the therapeutic mission of medicine.</p>","PeriodicalId":12044,"journal":{"name":"European journal of physical and rehabilitation medicine","volume":" ","pages":"182-189"},"PeriodicalIF":4.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}