European Journal of Dentistry最新文献

{"title":"The Effect of Intermittent Fasting on Salivary Inflammatory Cytokines and Dopamine Levels.","authors":"Elyazia Fayyad, Zumurd Al Anoud, Abdulkader Habra, Hussein Al Meshal, Aghila Rani K G, Roba Saqan, Zuha Rizvi, Manal Awad, Natheer Al-Rawi","doi":"10.1055/s-0045-1802345","DOIUrl":"10.1055/s-0045-1802345","url":null,"abstract":"<p><p>The current study elucidates potential alterations in inflammatory cytokines and dopamine (DA) levels in saliva following a 21-day fasting regimen during Ramadan and explores their associations with mental health parameters.Forty-four healthy young university students (22 females and 22 males; median age 22 (2) and body mass index 23.40 (6.23) were enrolled, and saliva samples were collected before and after fasting. Cytokine and DA levels were quantified by ELISA and LEGENDplex Human Inflammation Panel, respectively. Participants also completed the Patient Health Questionnaire-9 and Depression Anxiety Stress Scales questionnaires to assess mental health.Data analysis was performed using SPSS. Differences between pre- and postfasting were tested using Wilcoxon's signed-rank test. Mann-Whitney's <i>U</i> test determined disparities in DA and cytokine levels across sex. Simple and multiple linear regression analyses were performed to identify the factors influencing the change in DA. Correlation analysis was employed to explore the relationships between the changes in DA and cytokine levels before and after fasting.A significant increase in inflammatory cytokines such as interleukin (IL)-1β, interferon-α2, tumor necrosis factor-α, IL-23, IL-33, and IL-8 was observed after fasting. Anti-inflammatory cytokine, IL-10, levels remained unchanged. Females had significantly higher levels of proinflammatory cytokines before fasting compared with males, but no significant gender differences were observed after fasting. The current study also showed a significant decrease in DA levels after fasting; however, no significant difference in DA levels across genders was noted. Self-reported mental health status did not significantly change before and after fasting. Multiple linear regression analyses did not suggest potential associations between these variables and changes in DA levels before and after fasting. However, correlation analysis indicated that the change in inflammatory cytokine levels was inversely related to changes in DA levels.Fasting during Ramadan significantly increased salivary cytokine levels and decreased DA levels, indicating potential relationships between immune factors and mental well-being. The findings highlight the complex interplay between inflammation, immunity, and DA regulation during fasting. Further research is warranted to elucidate the potential long-term effects of these associations and their implications for mental health and well-being.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1084-1091"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Accuracy of Ceramic Veneer Alloy Related to Different Alloy Fabrication Techniques, Ceramic Veneering Methods, Stages, and Sites of Fabrication.","authors":"Sanephume Sripairojn, Niwut Juntavee, Apa Juntavee","doi":"10.1055/s-0044-1795079","DOIUrl":"10.1055/s-0044-1795079","url":null,"abstract":"<p><p>Fabrication processes affect accuracy of restoration. This study compared marginal accuracy of ceramic veneer metal upon different metal substructure fabrication techniques, ceramic veneering methods, stages, and sites of restoration.A prepared premolar metal abutment was used to fabricate 96 metal substructures from 4 techniques: cast metal with traditionally impressed tooth (CmTt), cast metal with digitally milled wax (CmDw), sintered metal with digitally impressed tooth (SmDt), and sintered metal with digitally impressed stone model (SmDm). As-cast (A) substructures were degassed (D), opaqued (O), and contoured (C) with porcelain layering (Pl) or press-on (Pp) methods and glazed (G). Marginal fit was measured at A, D, O, C, and G stages, on buccal (Bu), lingual (Li), mesial (Me), and distal (Di) sites using silicone replica.Analysis of variance and Bonferroni test were analyzed for significant differences of marginal fit upon different factors (<i>α</i> = 0.05).Significantly different accuracy was found upon metal substructures fabrication technique, veneering methods, stages, and sites of restoration (<i>p</i> < 0.05). SmDt and SmDm revealed significantly better accuracy than CmTt and CmDw (<i>p</i> < 0.05). Pp generated significantly better accuracy than Pl (<i>p</i> < 0.05). Significant increasing inaccuracy was found at D stage (<i>p</i> < 0.05). Me and Di sites exhibited larger inaccuracy than Bu and Li sites (<i>p</i> < 0.05). However, marginal inaccuracy for all groups was under clinically acceptable marginal fit.Increasing marginal inaccuracies upon stages of fabrication were noticed, with highly observed at the proximal site. Sintered metal provided better accuracy than cast metal, while press-on veneering generated better accuracy than the layering method. Porcelain press-on sintered metal was suggested for fabrication restoration.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"966-978"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing ChatGPT and Dental Students' Performance in an Introduction to Dental Anatomy Examination: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1055/s-0045-1809979","DOIUrl":"10.1055/s-0045-1809979","url":null,"abstract":"","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1203-1204"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Differences in Expression of Tumor Marker KI-67 and Proliferation Cell Nuclear Antigen (PCNA) in Ameloblastoma with Histopathological Subtypes Follicular, Plexiform, and Mixed (Follicular-Plexiform).","authors":"I Gusti Putra Swabuana Purwoyudho, David Buntoro Kamadjaja, R M Coen Pramono Danudiningrat, Muhammad Subhan Amir, Andra Rizqiawan, Indra Mulyawan, Okky Prasetio","doi":"10.1055/s-0044-1791220","DOIUrl":"10.1055/s-0044-1791220","url":null,"abstract":"<p><p>Ameloblastoma, though classified as a benign tumor, can induce deformities and functional abnormalities in the craniofacial region. Ki-67 is a typical marker for cell proliferation, with its expression peaking the M phase of the cell cycle or mitosis, indicating active cell division. Cells with high levels of Ki-67 expression are typically in a state of active proliferation. In addition, proliferating cell nuclear antigen (PCNA), a nuclear protein, plays a role in regulating the cell cycle and is involved in deoxyribonucleic acid (DNA) replication and repair processes. PCNA acts as a cofactor in DNA replication and repair processes.This study used 37 postoperative paraffin blocks for ameloblastoma patients in the period of 2015 to 2023. The samples in the inclusion criteria involved 24 samples with ameloblastomas diagnosis. Immunohistochemistries were used to observe the expression of Ki-67 and PCNA.The lowest expression of Ki-67 and PCNA was found in the plexiform subtype, whereas the highest expression values were found in mixed subtype (follicular-plexiform). The Tukey honestly significant difference test indicated a significant difference in Ki-67 expression in mixed subtypes compared to the plexiform and follicular types, with values of 0.001 (<i>p</i> < 0.05), and for PCNA expression was found with significant difference, 0.001 and 0.000 (<i>p</i> < 0.05), in the mixed subtypes, higher compared to the follicular and plexiform type.There is a significant difference in the expression values of Ki-67 and PCNA in the follicular subtype when compared to the plexiform subtype. However, no significant difference in values was observed between the follicular type and the mixed type.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"929-934"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of Cell Proliferation and Wound Closure in Cultured Gingival Epithelial Cells Using Plasma Rich in Growth Factors and Platelet-Rich Plasma Containing Leukocytes.","authors":"Yuri Watanabe, Katsumitsu Shimada, Yousuke Doi, Takuyoshi Higuchi, Yoshiya Kato, Xianqi Li, Yuji Kurihara, Satoshi Murakami","doi":"10.1055/s-0044-1801274","DOIUrl":"10.1055/s-0044-1801274","url":null,"abstract":"<p><p>Plasma rich in growth factors (PRGF) is presumed to be able to stimulate the regeneration of skin and periodontal tissue. This effect can be attributed to the fact that PRGF contains fewer leukocyte-derived interleukins in comparison to platelet-rich plasma (PRP). However, a comparison of the effects of PRGF and PRP on gingival epithelial cells has not been conducted yet. Therefore, our objective was to clarify and compare the effects of PRGF and PRP on gingival epithelial cell proliferation, wound healing, and gene expression.PRGF and PRP were obtained from three donors. A complete medium containing bovine pituitary extract (BPE) and growth factors was used as a positive control (PC), while a medium without BPE was used as a negative control (NC). We evaluated the presence of platelets and leukocytes, as well as the number of leukocytes, in PRP and PRGF using the cell block method and a cell counting chamber. We assessed gingival epithelial cell proliferation with WST-1 and wound healing by using cell-free culture inserts. To examine the mRNA expression of tumor necrosis factor-α (TNF-α), which is related to cell growth inhibition, and integrin β4, which contributes to cell adhesion, we used quantitative reverse transcription polymerase chain reactions (RT-PCRs) under PRGF and PRP samples in vitro. The nonparametric data were analyzed using the Kruskal-Wallis test.Large quantities of platelets were observed in both PRGF and PRP. The leukocyte concentration in PRGF was generally lower than that in PRP. Our report indicated that cell proliferation was significantly higher in PRGF than in PRP on day 1 and 2. We found that there was no significant difference in the wound closure rate between PRGF and PRP in comparison to their respective control groups. The quantitative RT-PCR revealed insignificant differences in mRNA expression as TNF-α and integrin β4 between PRGF and PRP in comparison to the each of their respective control groups.Our research indicated that PRGF can promote the proliferation of gingival epithelium more than PRP, contributing to the healing of periodontal tissue. TNF-α and integrin β4 mRNA expression may not be significantly involved in wound closure within the gingival epithelium under the influence of PRGF and PRP.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1055-1062"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Dry Mouth and Factors Associated with Sarcopenia on Oral Health-Related Quality of Life in Peritoneal Dialysis Patients.","authors":"Natcha Boonyapratheeprat, Kununya Pimolbutr, Dulyapong Rungraungrayabkul, Sasiwimon Meenetkum, Sarinya Boongird, Piyatida Chuengsaman, Nis Okuma, Supanee Thanakun, Chagriya Kitiyakara, Sujiwan Seubbuk Sangkhamanee","doi":"10.1055/s-0045-1802567","DOIUrl":"10.1055/s-0045-1802567","url":null,"abstract":"<p><p>This cross-sectional study aimed to investigate the oral health-related quality of life (OHRQoL), its associated factors, and the prevalence of possible sarcopenia in Thai well-maintained patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD).Data were collected from 63 participants undergoing PD at Banphaeo-Charoenkrung Hemodialysis Center. Dry mouth was evaluated through unstimulated salivary flow rate measurement and self-reported xerostomia questionnaires. OHRQoL was assessed using the Thai version of Oral Health Impact Profile (OHIP-14).Statistical analyses were conducted using IBM SPSS Statistics version 21.0. Descriptive statistics summarized participant characteristics, and normality was tested with the Kolmogorov-Smirnov test. Continuous variables were expressed as medians and interquartile ranges, while categorical variables were presented as frequencies and percentages. The Mann-Whitney <i>U</i> test and Fisher's exact test were used to assess differences between OHRQoL groups. Partial Spearman's rank correlation examined variable relationships, and logistic regression identified factors linked to a higher negative impact on OHRQoL, adjusting for age, sex, body mass index, chair stand test, and salivary flow rate. A <i>p</i>-value of < 0.05 was considered significant.The median age was 59 years (range 27-79), with a possible sarcopenia prevalence of 52.4%. OHIP-14 scores ranged from 0 to 32, with medians of 4 and 13 in a lower (<i>n</i> = 31) and higher (<i>n</i> = 32) negative impact on OHRQoL, respectively. Those with a higher negative impact on OHRQoL exhibited a significantly higher proportion of self-reported xerostomia (<i>p</i> = 0.01), lower salivary flow rate (<i>p</i> = 0.01), and longer 5-time chair stand test (<i>p</i> = 0.04) compared to individuals with the lower negative impact on OHRQoL. Correlation between the time of the chair stand test and the handgrip strength adjusting for age (<i>r</i> = -0.439, <i>p</i> < 0.001) and sex (<i>r</i> = -0.351, <i>p</i> = 0.006) was revealed. Multivariate logistic regression showed a significant association between salivary flow rate and a higher negative impact on OHRQoL (odds ratio 0.018; 95% confidence interval: 0.001, 0.545; <i>p</i> = 0.02).This finding suggests that reduced salivary flow affected OHRQoL in well-maintained ESRD patients with PD, highlighting the importance of managing dry mouth to alleviate their OHRQoL.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1127-1133"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Cement Thickness on Shear Bond Strength of Zirconia with Three Different Self-Adhesive Resin Cements.","authors":"Thofun Ieamsuwantada, Suparaksa Yamockul, Niyom Thamrongananskul, Atikom Surintanasarn, Awiruth Klaisiri","doi":"10.1055/s-0045-1806933","DOIUrl":"10.1055/s-0045-1806933","url":null,"abstract":"<p><p>This study aimed to evaluate the influence of resin cement thickness on the shear bond strength (SBS) of zirconia bonded with three different self-adhesive resin cements (SACs).One hundred and twenty zirconia specimens were prepared. Zirconia disks were milled into a cuboidal shape of size 8 × 8 × 6 mm³ using a milling machine, sintered according to the manufacturer's instruction, polished with sandpaper, airborne particle abraded with 50 μm aluminum oxide particles, and randomly divided into 12 groups (<i>n</i> = 10), according to the cement thickness (50, 100, 150, and 200 μm) and SAC (RelyX U200, PANAVIA SA LUTING Multi, and Maxcem Elite Chroma). The specimens were cemented to the resin composite blocks with SAC, stored in water at 37°C for 24 hours, and subjected to the SBS test. Mode of failure was evaluated under a stereo microscope. The data were statistically analyzed using two-way ANOVA and the Tukey HSD test to compare the differences in mean SBSs between groups at 95% confidence level.Statistical analysis revealed significant differences in SBS (<i>p</i> < 0.05) across the SACs, with the highest mean observed in the 50 μm cement thickness group and decreased as cement thickness increased. PANAVIA SA LUTING Multi exhibited the highest SBS, followed by the RelyX U200 groups, with the lowest SBS observed in Maxcem Elite Chroma groups (<i>p</i> < 0.05). In addition, the predominant mode of failure in all groups, except RelyX U200 and Maxcem Elite Chroma groups with the thickness of 200 μm, was score 4 (no resin cement remained on the zirconia surface).The difference in cement thickness and the type of SAC affected the SBS to zirconia. The lesser the cement thickness, the higher the SBS. 10-MDP-based cements, which provide the highest bond strength to zirconia and low cement thickness, are suggested for zirconia cementation to achieve a strong bond between zirconia and resin cement.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"948-955"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing and Evaluating Interprofessional Education for Dental Students: A Narrative Review.","authors":"Ahmed Yaseen Alqutaibi, Mohamed M Rahhal, Rawda Awad, Omer Sheriff Sultan, Mohamed A M Iesa, Muhammad Sohail Zafar, Mohamed Jaber","doi":"10.1055/s-0045-1804505","DOIUrl":"10.1055/s-0045-1804505","url":null,"abstract":"<p><p>Interprofessional education (IPE) and interprofessional collaborative practice are widely recognized for improving health care education and patient outcomes, especially in dentistry. Due to the strong link between oral and overall health, integrating IPE into dental curricula is essential for preparing practitioners to deliver collaborative, patient-centered care. A robust IPE curriculum for dental students requires well-defined learning outcomes aligned with other health professions and a focus on skills like patient care, communication, and teamwork. This review examines IPE curriculum design, implementation, and its impact on dental students, evaluating both short- and long-term effects on skills and career preparedness. By analyzing current IPE practices, this review seeks to illuminate effective strategies and future directions for integrating interprofessional collaboration into dental training.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"919-928"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apical Positioned Flap with a Combination of Mucograft and Fibro-Gide for Augmenting Keratinized Gingiva with Thin Gingival Phenotype: A Case Report.","authors":"Xin-Rui Zhu, Yi Liu","doi":"10.1055/s-0045-1810015","DOIUrl":"10.1055/s-0045-1810015","url":null,"abstract":"<p><p>The width and thickness of keratinized gingiva play a crucial role in the periodontal health and long-term stability of natural teeth. Noncrosslinked xenogeneic collagen matrix (Mucograft) has demonstrated favorable outcomes in augmenting keratinized gingival width (KGW), though its effect on increasing gingival thickness remains suboptimal. In contrast, crosslinked xenogeneic collagen matrix (Fibro-Gide) effectively enhances keratinized gingival thickness (KGT) but is unable to increase KGW. The aim of this study is to investigate the combined transplantation of Mucograft and Fibro-Gide in patients with thin gingival biotypes and insufficient KGW, evaluating whether this approach can simultaneously achieve both widening and thickening of the keratinized gingiva. This study selected a patient with a thin gingival biotype and insufficient KGW. A horizontal incision was made 0.5 mm above the mucogingival junction, and a partial-thickness flap was elevated and repositioned apically. Fibro-Gide was placed at the apical aspect of the surgical site, enveloped by the partial-thickness flap, while its coronal aspect was positioned in close contact with Mucograft, which was exposed in the surgical area. Both graft materials were securely sutured to the periosteum, ensuring partial contact with the keratinized gingiva. At the 12-month follow-up, the KGW increased from 1.5 to 3.5 mm and the KGT increased from 0.8 to 2.1 mm. For patients with a thin gingival biotype, the combined transplantation of Mucograft and Fibro-Gide can simultaneously augment the width of keratinized gingiva and increase gingival thickness.This technique has the following advantages: · Reduces the need of harvesting autologous soft tissue grafts.. · Minimal postoperative discomfort for the patient.. · Widens and thickens keratinized gingiva at the same time, and enhances the effect of XCM in patients with thin gingival phenotype..</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1215-1220"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Salivary Oxidative Stress Biomarkers and Clinical Severity of Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients.","authors":"Nurina Febriyanti Ayuningtyas, Fatimah Fauzi Basalamah, Gisela Lalita Brahmanikanya, Fatma Yasmin Mahdani, Adiastuti Endah Parmadiati, Desiana Radithia, Diah Savitri Ernawati, Madhu Shrestha, Ulinta Purwati Pasaribu, Satutya Wicaksono","doi":"10.1055/s-0045-1809184","DOIUrl":"10.1055/s-0045-1809184","url":null,"abstract":"<p><p>Radiation-induced oral mucositis (RIOM) is the most common side effect of radiotherapy (RT) in head and neck cancer (HNC) patients. Oxidative stress plays a major role in the multistep pathogenesis of RIOM. However, the current understanding of the relationship between salivary biomarkers of oxidative stress and the clinical severity of RIOM remains limited. This study aims to analyze the correlation between salivary oxidative stress biomarkers and the clinical severity of RIOM.This cross-sectional study analyzed the levels of salivary oxidative stress biomarkers from 25 HNC patients who underwent RT using enzyme-linked immunosorbent assay and the clinical grades of RIOM in the cohort. The data were then analyzed using the Spearman's correlation statistical test (<i>p</i>-value < 0.05).The findings demonstrated a significant correlation between salivary glutathione levels (<i>r</i>: -0.396; <i>p</i>: 0.050), superoxide dismutase levels (<i>r</i>: -0.447; <i>p</i>: 0.025), malondialdehyde levels (<i>r</i>: 0.479; <i>p</i>: 0.015), and lactate dehydrogenase levels (<i>r</i>: 0.460; <i>p</i>: 0.025) with the clinical severity of RIOM.The higher salivary oxidative stress correlates with higher severity of RIOM.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"1115-1119"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}