European Journal of Dentistry最新文献

{"title":"Critical Analysis of Reporting Quality of Network Meta-Analyses in Periodontology and Implantology.","authors":"Heba Mahmoud Ashi, Zohaib Khurshid","doi":"10.1055/s-0044-1801304","DOIUrl":"10.1055/s-0044-1801304","url":null,"abstract":"<p><p>The increasing recognition of network meta-analyses (NMAs) in dentistry, particularly in periodontology and implantology, lacks assessed reporting quality. To address this, our study will undertake a systematic review of previously reported NMAs. Researchers conducted an electronic search in Web of Science and Scopus to identify NMAs across all dentistry journals. Two independent investigators selected studies, extracted data, and assessed reporting quality using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for NMA (PRISMA-NMA) checklist with 32 items. Each \"yes\" response earned 1 point, and \"no\" responses received 0 points, yielding an overall reporting quality score. In total, 39 NMAs were included in this study. The NMAs were published between 2010 and October 2024, with most of them published in 2022 (25%). Most of the NMAs employed the PRISMA-NMA guidelines (47%) and have been published in the <i>Journal of Clinical Periodontology</i> (53%). The overall reporting quality of the included NMAs ranged between 87.5 and 100% (i.e., high quality of reporting [≥ 75th %]), with 5 NMAs reporting all 27 items of the PRISMA-NMA statement. The limitations, presentation of network structure (<i>results</i>), funding, and objectives (<i>methods</i>) were reported in 97, 94, 81, and 78% of the NMAs, respectively. The least reported items were the protocol registration and the summary of network geometry, which were reported in 53% of the NMAs. All the remaining items were reported in all 39 NMAs. The reporting quality of the NMAs published related to periodontology and implantology was high. However, some deficiencies were revealed associated with the reporting quality of the PRISMA-NMA items, including protocol registration, formulation of the research question based on the PICO (Population, Intervention, Comparison, Outcome) format, and summarization of the network geometry.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"551-562"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Properties of PEEK Post-Cores Compared to Other Post-Cores: A Systematic Review and Meta-Analysis.","authors":"Binoy Mathews Nedumgottil, Muhammad Faheemuddin","doi":"10.1055/s-0045-1806952","DOIUrl":"10.1055/s-0045-1806952","url":null,"abstract":"<p><p>Recently, polyetherpolyetherketone (PEEK) has gained popularity as a dental biomaterial. However, there is a lack of consensus on its potential use as an endodontic post-core material. The aim of this review was to systematically critique and synthesize the evidence on PEEK-based post-cores in comparison to other materials. An electronic search was conducted on PubMed, Medline, Embase, ISI Web of Science, Ovid, Cochrane, and ClinicalTrials.Gov using relevant keywords. Seven <i>in vitro</i> studies were included in this review. Meta-analysis of fracture resistance was carried out on results reported in three studies. Overall, in most of the studies, PEEK post-cores performed similar to glass-fiber post-cores. The meta-analysis revealed no significant difference between the fracture strengths of PEEK and glass-fiber post-cores. However, in most studies, several sources of bias were identified. Within the limitations of this review, it may be concluded that mechanical and physical properties of PEEK posts are similar to those of glass-fiber post-cores. Nonetheless, long-term clinical studies are required to translate these conclusions into clinical practice.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"607-616"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Regeneration Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Induced Damaged Submandibular Salivary Gland in Mice.","authors":"Nadia Attia Radi, Doaa Adel Habba, Seham Ibrahim Hallool, Ahmed Ali Almeshari, Hanaa Mohamed Abd Elsamia","doi":"10.1055/s-0044-1791940","DOIUrl":"10.1055/s-0044-1791940","url":null,"abstract":"<p><strong>Objectives: </strong> The ultimate goal of stem cell (SC) transplantation is the regeneration of salivary gland function by transplanted SCs differentiating into salivary gland cells. Therefore, this study aimed to evaluate the regenerative capacity of bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation in irradiated mice using the immunohistochemical markers Ki-67 and CD34.</p><p><strong>Material and methods: </strong> Four groups of male mice were included in the study. Group I (normal control) comprised six mice that were not subjected to gamma radiation. Group II comprised six irradiated mice that were not treated with BM-MSCs. Group III comprised 12 irradiated mice that were treated with intraglandular injection of labeled BM-MSCs into their submandibular salivary glands, 24 hours postradiation. Group IV comprised 12 irradiated mice that were treated with intraglandular injection of labeled BM-MSCs into their submandibular salivary glands, on day 11 postradiation.</p><p><strong>Statistical analysis: </strong> Data were presented as mean and standard deviation. The different groups were compared using a one-way analysis of variance (ANOVA).</p><p><strong>Results: </strong> The ANOVA test revealed that the difference between all groups was extremely statistically significant (<i>p</i> < 0.003), and Tukey's post hoc test revealed a statistically significant difference between group II and groups I, III, and IV included in the study regarding microvessel density of CD34 immunoexpression in different groups.</p><p><strong>Conclusion: </strong> BM-MSCs have a regeneration potential on induced damaged submandibular salivary glands in mice; time is an essential factor in the regeneration capacity of BM-MSCs.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"712-720"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Repair Materials and Surface Treatments on the Shear Bond Strength of 3D-Printed Provisional Restoration.","authors":"Pattaramon Hanpongkittikun, Wissanee Jia-Mahasap, Boonchai Chaoklaiwong","doi":"10.1055/s-0044-1791979","DOIUrl":"10.1055/s-0044-1791979","url":null,"abstract":"<p><strong>Objective: </strong> Despite the emergence of numerous three-dimensional (3D) printed provisional resin, there are no conclusive guidelines for repairing them. This study aims to investigate the effects of different repair materials and surface treatments on the shear bond strength of 3D-printed provisional resin.</p><p><strong>Materials and methods: </strong> A total of 180 3D-printed resin specimens underwent six surface treatments: no surface treatment (control), silicon carbide paper (SP), sandblasting with aluminum oxide (SB), SP followed by SB (SP + SB), SP with bonding agent (SP + BD), and SB with bonding agent (SB + BD). Each group was repaired with polymethyl methacrylate (PMMA), Bis-acryl, and flowable composite resin (FCR). The shear bond strength of the bonded specimens was tested using a universal testing machine and the mode of failure was examined with stereomicroscope.</p><p><strong>Statistical analysis: </strong> The Shapiro-Wilk test was used to assess normal distribution, and two-way analysis of variance (ANOVA; <i>α</i> = 0.05) was used to find the effect of independent variables on the shear bond strength. The post hoc test was achieved using the Tukey honest significant difference (HSD) test.</p><p><strong>Results: </strong> Two-way ANOVA indicated a statistically significant interaction between repair materials and surface treatments in relation to the shear bond strength of 3D-printed resin (<i>p</i> < 0.001). The three highest shear bond strengths overall were SB repaired with Bis-acryl (17.30 ± 0.77 MPa), SB + BD repaired with FCR (17.20 ± 0.29 MPa), and SB + BD repaired with PMMA (16.60 ± 0.71 MPa), which were significantly higher than their control group (<i>p</i> < 0.001). However, there were no significant differences between these groups. Notably the lowest shear bond strength in PMMA occurred in the control group (8.49 ± 0.42 MPa), while the lowest shear bond strength in Bis-acryl and FCR was observed in the SP group (7.28 ± 0.71 and 8.84 ± 1.15 MPa, respectively).</p><p><strong>Conclusion: </strong> Repair materials and surface treatments play an important role in repairing 3D-printed resin. PMMA and composite resin-based repair materials require both sandblast and a chemical bonding agent, while Bis-acryl-based repair materials only need sandblasting to improve the shear bond strength.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"735-742"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial and Antibiofilm Properties of Hydroxyapatite/Nano-Hydroxyapatite in Preventing Dental Caries: A Systematic Review.","authors":"Nurdiana Dewi, Meirina Gartika, Dwi Gustiono, Dikdik Kurnia, Arief Cahyanto","doi":"10.1055/s-0045-1802568","DOIUrl":"10.1055/s-0045-1802568","url":null,"abstract":"<p><p>Controlling biofilm is a crucial strategy and an essential component of preventing dental caries. Considerable research has been conducted in recent years on the clinical application of hydroxyapatite (HAp) and hydroxyapatite nanoparticles (nHAp) in preventing dental caries. However, these studies have yet to investigate the effectiveness or mechanism of these substances as antibacterial and antibiofilm agents. This study aimed to provide a thorough analysis of the current evidence on the antibacterial and antibiofilm characteristics of HAp/nHAp in the prevention of dental caries. Searches were conducted across five databases: Cochrane Library, PubMed, Scopus, EBSCOhost, and ScienceDirect. Google Scholar was also searched. Titles, abstracts, and full text were evaluated following the guidelines set by the Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA). A methodological quality assessment of the studies was conducted using the QUIN tool. The initial retrieval totaled 15,047 studies, from which 3,487 were excluded. A total of 11,560 studies were screened based on the title and abstract, resulting in 24 full-text studies considered potentially eligible for inclusion (<i>κ</i> = 0.9599). Finally, 19 studies met all the defined inclusion criteria and were included in this comprehensive systematic review (<i>κ</i> = 0.8837). HAp/nHAp demonstrates antimicrobial activities against gram-negative and gram-positive bacteria and fungi. However, nHAp's antibiofilm efficacy remains limited. Further investigation is required to improve the efficacy of antibacterial and antibiofilm agents.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"563-579"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cadherin Single Nucleotide Variants Are Associated with Increasing Susceptibility to Periodontitis.","authors":"Nadia M Kazem, Ali A Abdulkareem, Paul R Cooper, Michael R Milward","doi":"10.1055/s-0044-1791683","DOIUrl":"10.1055/s-0044-1791683","url":null,"abstract":"<p><strong>Objectives: </strong> To investigate the association of <i>E-cadherin</i> single nucleotide polymorphisms (SNPs) with periodontitis and the potential of these SNPs for identifying susceptibility to periodontitis.</p><p><strong>Materials and methods: </strong> Periodontal clinical parameters were recorded followed by collecting venous blood for DNA extraction. Polymerase chain reaction was used to amplify target segments of the <i>E-cadherin</i> gene. Determination of the genotype and allele frequencies was performed using Sanger sequencing. All statistical analyses were performed using GraphPad Prism (version 9) using a statistically significant difference of <i>p</i> < 0.05.</p><p><strong>Results: </strong> A total of 207 participants were recruited into two groups of healthy controls (<i>n</i> = 105) and cases diagnosed with periodontitis stage 2 or 3, grade B or C (<i>n</i> = 102). Analyses indicated that the genotypes and alleles of rs3743674 and rs5030625 <i>E-cadherin</i> SNPs were significantly associated with periodontitis. Results from a binary regression model suggested that the presence of these SNPs may indicate susceptibility to periodontitis and increase the rate of progression. Linkage disequilibrium analysis indicated that <i>E-cadherin</i> variants rs3743674 and rs5030625, and rs10272115 and rs16260 were correlated in a nonrandom manner (<i>r</i> ² = 0.638 and 0.495, respectively).</p><p><strong>Conclusion: </strong> E-cadherin gene variants, rs3743674 and rs5030625, were associated with the periodontitis phenotype. These biomarkers may identify individuals susceptible to periodontitis and the rate of disease progression.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"650-659"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Active MMP-8 Point-of-Care Test in Peri-Implantitis.","authors":"Ioannis Fragkioudakis, Leonidas Batas, Ioannis Vouros, Dimitra Sakellari","doi":"10.1055/s-0044-1793843","DOIUrl":"10.1055/s-0044-1793843","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to evaluate the diagnostic sensitivity and specificity of the active matrix metalloproteinase-8 (aMMP-8) quantitative chairside point-of-care (PoC) lateral flow immunotest for peri-implant diseases, and it sought to correlate aMMP-8 levels with clinical parameters to determine its effectiveness as a biomarker for peri-implantitis.</p><p><strong>Materials and methods: </strong> A cross-sectional study was conducted at the Department of Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. Participants included systemically healthy individuals with at least one implant loaded for more than 1 year, who had not received periodontal treatment or antibiotics in the preceding 6 months. Exclusion criteria included diabetes and immune-compromising conditions. Peri-implant sulcular fluid (PISF) samples were collected from the mesiobuccal or distobuccal site of the implant. The quantitative chairside PoC lateral flow immunotest for peri-implant diseases (ImplantSafe test) and ORALyzer digital reader were used to analyze PISF, with results expressed in ng/mL. Clinical parameters such as bleeding on probing (BOP), probing depth (PD), recession (REC), and clinical attachment level (CAL) were measured at six sites per implant using a 15-mm scale periodontal probe.</p><p><strong>Results: </strong> No significant differences were found in age, gender distribution, or smoking status between the healthy/mucositis and peri-implantitis groups. The peri-implantitis group showed significantly higher mean percentages of BOP (57.58 ± 31.73 vs. 18.79 ± 24.17), PD (4.59 ± 1.22 mm vs. 2.94 ± 0.78 mm), and CAL (5.21 ± 1.72 mm vs. 3.05 ± 0.81 mm). aMMP-8 levels were also significantly higher in the peri-implantitis group (53.39 ± 49.70 vs. 22.03 ± 32.87). The diagnostic test demonstrated a sensitivity of 81.25% and specificity of 74.07%, with an area under the curve of 79.6%, indicating overall good accuracy in distinguishing between positive and negative conditions.</p><p><strong>Conclusion: </strong> The aMMP-8 is a promising biomarker for peri-implantitis, showing elevated levels in affected patients. The aMMP-8 chairside test demonstrates high diagnostic sensitivity and specificity, supporting its use in early detection and monitoring of peri-implant diseases. Further research is needed to establish standardized protocols for its clinical application and to explore its long-term predictive value in implant care.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"743-748"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Soft Skills in Dental Education: Challenges and Importance.","authors":"Murali Venkata Rama Mohan Kodali, Unati Sai Kodali, Srikanth Gadicherla, Komal Smriti, Anupam Singh, Zohaib Khurshid","doi":"10.1055/s-0044-1791938","DOIUrl":"10.1055/s-0044-1791938","url":null,"abstract":"<p><p>Soft skills encompass interpersonal abilities and values that enable individuals to adapt to diverse circumstances. In dentistry, a combination of soft and hard skills is crucial for successful practice and for achieving health care organization goals. However, dental schools face significant challenges in teaching and evaluating soft skills, including the subjective nature of assessment, variability in student engagement, and the lack of standardized curricula. The development of ethical and critical thinking skills is essential for students to balance competing interests in the profession while maintaining professionalism, such as dedication, accountability, competence, dependability, and respect for others. Health care professionals, including dentists, must cultivate soft skills to effectively guide and treat patients. This study aims to raise awareness of the importance of soft skills in dental education, specifically highlighting challenges in instruction and evaluation. Key conclusions include the need for a more structured approach to teaching soft skills, integrating them into the broader curriculum, and developing more objective assessment tools. By addressing these issues, dental education can better equip future dentists with the necessary skills for efficient patient care.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"851-859"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Craniofacial Growth Pattern Relative to Respiratory Mandibular Movement and Sleep Characteristics: A Pilot Study.","authors":"Sukaynah Al-Awami, William Tanberg, Alberto Monegro, David Covell, Jean-Benoit Martinot, Thikriat Al-Jewair","doi":"10.1055/s-0044-1795120","DOIUrl":"10.1055/s-0044-1795120","url":null,"abstract":"<p><strong>Objectives: </strong> The primary objective was to evaluate the influence of sagittal skeletal pattern on mandibular movement (MM) during sleep in growing orthodontic populations. The secondary objective was to compare MM according to obstructive sleep apnea (OSA) status.</p><p><strong>Materials and methods: </strong> This cross-sectional study included subjects between 6 and 17 years old, presenting with class I, II, and III skeletal patterns and no previous history of orthodontic treatment. A wireless sensor connected to the patient's chin before bedtime and removed the next day was used to record MM signals. The signals were analyzed using a machine learning algorithm to measure sleep and MM outcomes. MM variables included percentage change in waveform prominence (%), variance in peak prominence, mean prominence values, length of events (seconds), respiratory rate per minute, dominant frequency, and amplitude of dominant frequency. The obstructive respiratory disturbance index determined from the sensor was used to confirm OSA status.</p><p><strong>Results: </strong> There was no statistically significant difference in MM variables between class I, II, and III subjects. When compared according to OSA status, the amplitude of dominant frequency was significantly higher in the OSA than the non-OSA group (<i>p</i> = 0.005). When evaluated according to both skeletal classification and OSA status, the class I OSA subjects showed a higher median value than the non-OSA class I group (<i>p</i> = 0.016).</p><p><strong>Conclusion: </strong> Within the limits of this study, the sagittal skeletal pattern had no effect on the respiratory MM. This study did not find a correlation between craniofacial pattern and MM and OSA.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"768-776"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of CAD-CAM Workflow Variations on the Marginal and Internal Gaps and Fatigue Behavior of Ceramic and Resin Composite Dental Crowns.","authors":"Rafaela Oliveira Pilecco, Lucas Saldanha da Rosa, Andrea Baldi, Renan Vaz Machry, João Paulo Mendes Tribst, Luiz Felipe Valandro, Cornelis Johannes Kleverlaan, Nicola Scotti, Gabriel Kalil Rocha Pereira","doi":"10.1055/s-0044-1791705","DOIUrl":"10.1055/s-0044-1791705","url":null,"abstract":"<p><strong>Objectives: </strong> To analyze the marginal/internal gap and the fatigue behavior of crowns made of two different materials, using four combinations of a digital workflow-two intraoral scanners (IOSs) and two milling machines.</p><p><strong>Materials and methods: </strong> Crowns were made considering three factors: IOS (a confocal microscopy-based scanner: TRIOS 3-TR; or a combination of active triangulation and dynamic confocal microscopy: Primescan-PS), milling machines (four-axis: CEREC MC XL-CR or five-axis: PrograMill PM7-PM), and restorative material (lithium disilicate-LD or resin composite-RC) (<i>n</i> = 10). The bonding surface of each crown was treated and bonded to each respective glass fiber-reinforced epoxy resin die using a dual-cure resin cement. A computed microtomography analysis was performed to access marginal/internal gap. The specimens were subjected to a cyclic fatigue test (20 Hz, initial load = 100 N/5,000 cycles; step size= 50 N/10,000 cycles until 1,500 N, then if specimens survived, the step size was increased to 100 N/10,000 cycles).</p><p><strong>Statistical analysis: </strong> For data analysis, three-way analysis of variance and Kaplan-Meier with log-rank (Mantel-Cox) test were performed (α = 0.05).</p><p><strong>Results: </strong> TR resulted in a smaller axial-occlusal angle and occlusal gap, and five-axis milling resulted in a smaller marginal gap, axial-occlusal angle, and occlusal gap. Angled points and occlusal surface showed a tendency for overmilling. RC crowns displayed higher survival rates and a more pronounced topography compared with LD independently of the scanning and milling method. LD crowns produced with a five-axis milling machine resulted in higher fatigue performance and rougher topography compared with a four-axis machine.</p><p><strong>Conclusion: </strong> RC crowns displayed better fatigue behavior compared with LD, while LD benefited from a five-axis machine for improved survival probability.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"638-649"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}