European journal of orthodontics最新文献

{"title":"Long-term comparison of maxillary protraction with hybrid hyrax-facemask vs. hybrid hyrax-mentoplate protocols using Alt-RAMEC: a 5-year randomized controlled trial.","authors":"Joeri Meyns, Jeroen Meewis, Flore Dons, Arnoud Schreurs, Johan Aerts, Sohaib Shujaat, Constaninus Politis, Reinhilde Jacobs","doi":"10.1093/ejo/cjaf011","DOIUrl":"10.1093/ejo/cjaf011","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to compare the short- and long-term effectiveness of hybrid Hyrax (HH) -Facemask (FM) and HH-mentoplate (MP) treatment protocols for maxillary protraction using Alt-RAMEC.</p><p><strong>Methods: </strong>A single-center 2-arm parallel randomized controlled trial. Participants: 28 skeletal class III patients (female: 14, male: 14; average age: 9.7 ± 1.3 years;) were included. Interventions: Two treatment groups where protraction therapy was combined with Alt-RAMEC. Group 1: Facemask group (Hybrid Hyrax + Facemask) and Group 2: Mentoplate group (Hybrid Hyrax + Mentoplate). Objective: To compare skeletal and dental changes between groups using low dose computed tomography (CT) scan from which virtual lateral cephalograms were generated. Outcome: Outcomes include changes in Wits appraisal (primary outcome), and cephalometric analysis of skeletal and dental changes (secondary outcomes) at 1 year and 5 years after treatment initiation. Randomization: 28 patients were allocated to either treatment-protocols using sequentially numbered opaque, sealed envelopes. The randomization sequence was generated with a 1:1 allocation ratio. Blinding: Due to the nature of the trial, the operator and children could not be blinded to the treatment allocation. However, blinding was used when assessing the outcomes.</p><p><strong>Results: </strong>Follow-up: one patient was lost at the one-year follow-up and an additional three patients were lost at the 5-year follow-up. Outcomes: Both treatment protocols effectively improved intermaxillary relationship. Wits measurements showed improvements of 4.42 mm (FM) and 2.86 mm (MP) at T1, decreasing slightly to 3.33 mm (FM) and 1.50 mm (MP) at T2. While vertical control and incisor inclination were comparable between groups long-term, short-term differences were noted in upper and lower incisor inclination. Results remained equally stable after five years (T2). Harms: minor harms were encountered with the anchor hooks (fracture or mucosal irritation), however none led to treatment cessation.</p><p><strong>Conclusions: </strong>Early class III treatment with HH + MP provided similar outcomes and stability to that of HH + FM suggesting that the choice between FM and MP should be based on individual patient factors rather than presumed mechanical advantages.</p><p><strong>Trial registration: </strong>Clinical Trials ID: NCT02711111.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Does the pain experienced during orthodontic treatment and bracket removal depend on the architecture of the bracket or debonding method?","authors":"","doi":"10.1093/ejo/cjaf016","DOIUrl":"10.1093/ejo/cjaf016","url":null,"abstract":"","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palatal canine impaction is not associated with third molar agenesis.","authors":"Christianna I Papadopoulou, Maria Athanasiou, Nikolaos Gkantidis, Georgios Kanavakis","doi":"10.1093/ejo/cjaf008","DOIUrl":"10.1093/ejo/cjaf008","url":null,"abstract":"<p><strong>Background/objectives: </strong>Third molar agenesis and palatally impacted canines (PICs) are two independent dental phenotypes with different developmental backgrounds. Isolated reports indicate a common genetic origin for both, however, current data is inconsistent. The aim of this study was to investigate the presence of third molar agenesis in individuals with PICs, compared to individuals without PICs.</p><p><strong>Materials/methods: </strong>This retrospective case-control study comprised 310 individuals (188 females and 122 males), half of whom presented with unilateral or bilateral PICs. Individuals with other dental anomalies of known genetic origin were excluded. The association between PICs and third molar agenesis was assessed using four regression models, with PIC as the dependent variable and sex, age, and third molar agenesis as predictors. One model treated PIC as a nominal variable (pattern) and the other as ordinal (severity), and both were run testing either third molar agenesis severity or third molar agenesis patterns. All statistical tests were performed assuming a type-1 error of 5%.</p><p><strong>Results: </strong>There was no significant association between canine impaction and third molar agenesis in any of the four regression models. Neither the severity nor the patterns of palatally impacted canines were associated with either the severity or the patterns of third molar agenesis (P > .05).</p><p><strong>Limitations: </strong>Due to the common racial background of all participants, the results of this investigation might not be generalizable to the general population.</p><p><strong>Conclusions/implications: </strong>Palatal canine impaction is not associated to third molar agenesis, after accounting for age, sex, and various patterns of PICs and third molar agenesis. These results indicate that these two dental phenotypes do not share a common biological mechanism for their occurrence.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of genetic and environmental factors on transverse growth.","authors":"Sameer Al-Obaidi, Spyridon N Papageorgiou, Marianne Saade, Kristina M Caradonna, Alpdogan Kantarci, Leslie Will, Melih Motro","doi":"10.1093/ejo/cjaf003","DOIUrl":"10.1093/ejo/cjaf003","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to determine the genetic and environmental effects on transverse growth of craniofacial structures, within and between identical and fraternal twins.</p><p><strong>Methods: </strong>The sample consisted of 142 children in total, divided into 29 pairs of monozygotic twins, 42 pairs of dizygotic twins, and 1 set of dizygotic triplets. Postero-anterior cephalometric radiographs were taken at the ages of 9, 12, and 15 years. Intercanine width, maxillary width, mandibular width, nasal width, and facial width variables were measured. The genetic and environmental components of variance were analyzed with structural equation modeling for multilevel mixed effects.</p><p><strong>Results: </strong>Intercanine width was initially mainly characterized by a moderate genetic component at 9 years (53%), with environmental influence increasing at age 12 (36%) and peaking at 15 years (84%). Maxillary width was under strong genetic influence at 9 years (70%), with genetic influence remaining strong up to 15 years (73%). Mandibular width was under additive genetic influence at 9 years (76%), with dominant genetic influence remaining high at 15 years (81%). Nasal width was under strong additive genetic influence at 9 years (69%) but switched to increased environmental influence at 15 years (59%). Finally, facial width had a moderate genetic influence at 9 years (66%), which increased at 15 years (90%).</p><p><strong>Limitations: </strong>This study included patients of European descent, which may limit the generalizability of the findings to other ethnic groups.</p><p><strong>Conclusions: </strong>Although monozygotic and dizygotic twins share at least part of their genetic material, environmental factors accounted for about 10%-84% of variability at various ages, with intercanine width being most affected.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially-dense three-dimensional analysis of the midfacial skeletal shape asymmetry in skeletal Class III patients.","authors":"Guangpu Zhao, Xinyu Su, Aonan Wen, Yiming Li, Yong Wang, Yijiao Zhao, Danqing He, Yan Gu","doi":"10.1093/ejo/cjaf010","DOIUrl":"10.1093/ejo/cjaf010","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to analyze midfacial skeletal shape asymmetry in skeletal Class III patients using a three-dimensional spatially-dense method.</p><p><strong>Methods: </strong>Sixty skeletal Class III patients' cone-beam computed tomography images were retrospectively enrolled and divided into three groups according to occlusal plane inclination (OPI) and mandibular lateral deviation (MD). A spatially-dense template of the anterior outer surface of the midfacial skeleton was established and validated. Through template registration, a large number of homologous quasi-landmarks of the midfacial skeleton were automatically identified. After robust superimposition of the original and mirror images, the root-mean-square error was calculated as the asymmetry index (AI). Color-coded maps were generated to visually display the location and magnitude of the asymmetry.</p><p><strong>Results: </strong>The median overall midfacial skeletal AIs of group 1 (with OPI and MD), group 2 (with MD without OPI), and group 3 (without OPI or MD) were 1.55, 1.27, and 1.19, respectively. The overall AI of group 1 was significantly higher than that of group 2 (P < .05) and group 3 (P < .01). Within group 1, the AI of the alveolar process was significantly higher than that of other regions.</p><p><strong>Conclusions: </strong>The three-dimensional spatially-dense method allows quantitative and visual analysis of shape asymmetry of the midfacial skeleton. Skeletal Class III patients with occlusal plane inclination and mandibular lateral deviation exhibit a significantly greater degree of midfacial skeletal asymmetry, with the alveolar process identified as the main asymmetric site of their midfacial skeleton.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of micro-osteoperforation (MOP) in molar distalization treatments: an exploratory systematic review and meta-analysis of RCTs.","authors":"Erfan Bardideh, Mahsa Ghorbani, Mina Fani Disfani, Hooman Shafaee, Fatemeh Mehmani","doi":"10.1093/ejo/cjaf004","DOIUrl":"10.1093/ejo/cjaf004","url":null,"abstract":"<p><strong>Objective: </strong>Molar distalization is a therapeutic approach commonly used for treating Class II malocclusions. However, the extended duration of this treatment often leads to its replacement with alternative methods that offer shorter treatment times. Micro-osteoperforation (MOP) has been introduced as a technique aimed at accelerating tooth movement and reducing treatment duration. The purpose of this study is to evaluate the impact of MOP on molar distalization outcomes to provide evidence for its effective and safe use.</p><p><strong>Search methods: </strong>A comprehensive search was conducted across multiple databases, including MEDLINE, Web of Science, EMBASE, Scopus, and Cochrane's CENTRAL, up to April 2024, without any language or date restrictions.</p><p><strong>Selection criteria: </strong>Only randomized clinical trials (RCTs) that addressed the defined PICO question were included in the analysis. The risk of bias in the included studies was assessed using the Cochrane Risk of Bias 2.0 (RoB 2) tool.</p><p><strong>Data collection and analysis: </strong>Relevant data were extracted using custom-designed forms, and a random-effects inverse variance meta-analysis was performed to synthesize the results. The primary outcomes analyzed were the rate and amount of molar distalization, while secondary outcomes included pain levels, root resorption, and periodontal health.</p><p><strong>Results: </strong>Four RCTs, involving a total of 71 participants, were included in this exploratory review. Most studies were at low or some concerns risk of bias. The meta-analysis revealed no significant differences in the rate or amount of molar distalization between the MOP and control groups (mean difference [MD] = 0.1 mm/month and 0.01 mm, respectively, P > .05). However, the MOP group reported significantly higher pain levels on the day of the procedure (MD = 2, P = .01) on a 10-point visual analog scale (VAS) compared to the control group. This difference in pain perception was no longer significant seven days after the procedure (MD = 0.52, P = .52).</p><p><strong>Conclusion: </strong>While MOP is associated with increased immediate postoperative pain, it does not significantly enhance the efficiency of molar distalization. Therefore, the use of MOP for distalization should be judiciously considered and reserved for cases that involve particularly challenging or prolonged movements, based on the specific needs and characteristics of each patient. Limitations of this review include the small number of available RCTs and variability in MOP protocols, which may limit the generalizability of the findings.</p><p><strong>Registration: </strong>The protocol for this systematic review was registered at PROSPERO with the ID CRD42024589482.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of premolars in orthodontic treatment does not negatively affect upper airway volume and minimum cross-sectional area: a systematic review with meta-analysis.","authors":"Spyridon N Papageorgiou, Maria Zyli, Alexandra K Papadopoulou","doi":"10.1093/ejo/cjaf012","DOIUrl":"10.1093/ejo/cjaf012","url":null,"abstract":"<p><strong>Background: </strong>Extraction of premolars is usually prescribed for the orthodontic treatment of cases with inadequate space within the dental arch or when anterior teeth retraction is indicated; however, it has been advocated that this treatment approach could negatively influence the airways.</p><p><strong>Objective: </strong>To identify and critically appraise studies of premolar extractions during orthodontic treatment on upper airway dimensions. Search methods: Electronic unrestricted searches in nine databases until October 2024. Selection criteria: Clinical studies on humans comparing comprehensive orthodontic treatment with versus without the extraction of premolars using cone-beam computed tomography to assess upper airway volume or minimum cross-sectional area (minCSA). Data collection and analysis: After duplicate study selection, data extraction, and risk-of-bias assessment according to Cochrane, random-effects meta-analyses of Mean Differences (MD) with their 95% confidence intervals (CI) were performed, followed by subgroup/meta-regression analyses and assessment of the quality of evidence.</p><p><strong>Results: </strong>Twelve papers corresponding to 11 unique retrospective non-randomized studies were included, covering 891 patients (35.8% male; 20.0 years-old on average). No statistically significant differences in the effect of orthodontic treatment on the volume of the nasopharynx, palatopharynx, glossopharynx, oropharynx or oral cavity were seen between patients treated with versus without premolar extractions (P > .05). Similarly, no significant differences were seen between extraction and non-extraction patients in terms of minCSA of the nasopharynx, palatopharynx, or glossopharynx (P > .05). On the contrary, patients treated with premolar extractions showed increased minCSA of the oropharynx compared to those treated without premolar extractions (4 studies; MD = 23.00 mm2; 95% CI = 10.74-35.26 mm2; P = .009). No significant effects from patient age, sex, or equivalence of the extraction/non-extraction groups were found, while the strength of evidence was moderate in all cases due to the inclusion of non-randomized studies with high risk of bias.</p><p><strong>Conclusions: </strong>Limited evidence of moderate strength indicates that, on average, premolar extractions during comprehensive orthodontic treatment have little to no effect on the volume and minCSA of the airways.</p><p><strong>Registration: </strong>CRD42024621355.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative assessment of stability and satisfaction between two mandibular lingual retainers in orthodontic patients. A 2-year follow-up, single practice-based randomized trial.","authors":"Dorota Tymińska, Ewa Węgrodzka, Nikolaos Pandis, Potr S Fudalej","doi":"10.1093/ejo/cjaf013","DOIUrl":"10.1093/ejo/cjaf013","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate and compare the stability of mandibular dental arch dimensions and patient satisfaction between two types of fixed retainers-3-strand round twisted (RT) and 8-strand rectangular braided (RB)-both of which are bonded to all six anterior mandibular teeth.</p><p><strong>Trial design: </strong>2-arm parallel, two-center prospective randomized controlled trial.</p><p><strong>Methods: participants: </strong>133 orthodontic patients (median age 24.6 years, 25th percentile = 17.2 years, 75th percentile = 32.4 years) were recruited.</p><p><strong>Interventions: </strong>These patients were randomly assigned to receive either an RT or RB wire retainer at a 1:1 ratio.</p><p><strong>Randomization: </strong>It was achieved using random permuted blocks of sizes 4, 6, or 8, which were concealed in sequentially numbered, opaque, sealed envelopes.</p><p><strong>Outcomes: </strong>The primary outcome was the change in the irregularity index, with secondary outcomes including arch length; intercanine, interpremolar, and intermolar widths; and patient satisfaction. Evaluations were performed at baseline and at 3, 6, 12, 18, and 24 months after retainer placement. Dental cast measurements were analyzed using random effects linear regression, and satisfaction was assessed at each time point.</p><p><strong>Blinding: </strong>Blinding of patients was not feasible. Only blinding the assessor for patient satisfaction was achieved.</p><p><strong>Results: </strong>Cast measurements remained relatively stable from T1 to T6, with no significant difference attributed to the retainer type (RT or RB). Time significantly affected all cast measurements except for the irregularity index. There was no significant correlation between retainer type or time and satisfaction questionnaire responses, although the responses varied by question. No harms were observed.</p><p><strong>Conclusions: </strong>Both RT and RB wire retainers effectively maintain mandibular arch alignment and are equally well tolerated by patients in the medium term.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of upper second molar eruption status on the efficiency of upper first molar distalization: a systematic review and meta-analysis.","authors":"Umar Hussain, Rabia Sadiq, Sakina Kazmi, Abdul Wahab, Gulsana Hashmi, Muhammad Noman, Farhana Umer, Muhammad Tayab Khalily, Alessandra Campobasso, Nikoloas Pandis","doi":"10.1093/ejo/cjaf007","DOIUrl":"10.1093/ejo/cjaf007","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the distalization, tipping, and vertical movement of the maxillary first permanent molar in patients with and without erupted maxillary second molar (MSM).</p><p><strong>Methods: </strong>Eligibility criteria: Randomized/non-randomized clinical studies comparing distalization, tipping, and vertical movement of the maxillary first permanent molar in patients with and without erupted MSM. Information sources: Unrestricted literature search of six databases was conducted up to May, 2024. Risk of bias: The quality assessment of the studies was conducted using the Cochrane Risk of Bias Tool (ROBINS-I). Synthesis of results: Random effects meta- analyses using standardized mean differences (SMDs) and their 95% confidence intervals (CIs) were performed, followed by meta-regressions, sensitivity analyses, and assessment of the quality of evidence using GRADE.</p><p><strong>Results: </strong>Included studies: Eleven studies (8 retrospective and 3 prospective non-randomized trials) involving 562 participants (43.97% male) were included. Synthesis of results: Distalization was significantly more effective when the maxillary second molar was unerupted (9 studies; SMD = -0.41; 95% CI: -0.81--0.004; P = .04; I² = 68.6%). The eruption status of MSM has no significant effect on tipping (8 studies; SMD = -0.27; 95% CI: -0.68-0.15; P = .17), and vertical movement (4 studies; SMD = 0.08; 95% CI: -0.32-0.48; P = .57) of upper first molars during distalization. Sensitivity analyses showed no significant differences based on study design, appliance type, or anchorage type, confirming the robustness of the findings. The certainty in the estimates was very low due to high risk of bias, methodological weaknesses, and small sample sizes.</p><p><strong>Discussion: </strong>Limitations of evidence: The inclusion of non-randomized, mostly retrospective studies, unmatched baseline, Class II severity, and insufficient reporting of treatment duration are key limitations. Interpretation: Very low level of evidence indicates that it may be preferable to perform distalization before the eruption of the upper second molar.</p><p><strong>Registration: </strong>PROSPERO (CRD42024591126).</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and environmental contributions to the development of dental arch traits: a longitudinal twin study.","authors":"Jamal Giri, Michelle Bockmann, Alan Brook, Angela Gurr, Lyle Palmer, Toby Hughes","doi":"10.1093/ejo/cjaf018","DOIUrl":"10.1093/ejo/cjaf018","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to estimate the relative contributions of genetic and environmental factors to phenotypic variations of dental arch traits from primary to permanent dentition stages.</p><p><strong>Methods: </strong>Digital dental models of 188 Australian twin pairs (90 monozygotic and 98 dizygotic) in the primary dentition stage, followed up through the mixed and permanent dentition stages, were included in the study. Landmarks were identified on both maxillary and mandibular dental arches in MeshLab for measuring intercanine widths, intermolar widths, arch lengths, overjet, overbite and molar relationships. Genetic structural equation modelling was performed on the quantitative twin data of dental arch traits.</p><p><strong>Results: </strong>The phenotypic variance of dental arch traits was generally best explained by a model incorporating additive genetic (A) and non-shared environmental (E) components, an AE model. However, the variance of overjet in the primary dentition was best explained by shared environmental (C) and non-shared environmental (E) components. Heritability estimates were high for intra-arch traits (0.65-0.88), but low to moderate for inter-arch traits (0.21-0.51). While heritability estimates fluctuated for most traits from primary to permanent dentition stages, the estimates for arch lengths and intermolar widths were mostly above 0.8 throughout development.</p><p><strong>Limitation: </strong>Only twins of European descent were included in this study.</p><p><strong>Conclusions: </strong>Dental arch traits were mostly influenced by additive genetic and non-shared environmental factors during development. Except for arch lengths and intermolar widths, genetic and environmental influences on dental arch traits fluctuated during development, with the genetic influence at its lowest during the mixed dentition stage.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}