European journal of orthodontics最新文献

{"title":"Reply to Letter to the Editor.","authors":"Hasan Alzoubi, Rabea A Ghareeb","doi":"10.1093/ejo/cjag017","DOIUrl":"10.1093/ejo/cjag017","url":null,"abstract":"","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of class III treatment using intermaxillary elastics and buccal shelf miniscrews.","authors":"Raphael Dutra de Resende Mendonça, Célia Regina Maio Pinzan, Karina Maria Salvatore Freitas, Paula Cotrin, Rossana Gisselle Zelaya Sosa, Fabricio Pinelli Valarelli","doi":"10.1093/ejo/cjag042","DOIUrl":"10.1093/ejo/cjag042","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study aimed to compare the treatment effects of extra-alveolar skeletal anchorage versus intermaxillary elastics in Class III patients.</p><p><strong>Materials/methods: </strong>Thirty-eight patients were divided into three groups based on their treatment approach. Group Buccal Shelf (BS) consisted of 10 patients treated with a fixed orthodontic appliance and buccal shelf miniscrews (initial mean age: 21.44 years; mean treatment time: 2.81 years). Group Elastics Torque (ET) comprised 14 patients treated with fixed orthodontic appliance (lower incisors with buccal torque, and upper incisors with torque zero) and intermaxillary elastics (initial mean age: 18.97 years; mean treatment time: 3.12 years). Group Elastics (E): 14 patients treated with a fixed orthodontic appliance (lower incisors torque zero, and upper incisors with buccal torque) and intermaxillary elastics (mean initial age: 19.18 years; mean treatment time: 3.15 years). Cephalograms were taken before and after orthodontic treatment. Dental, skeletal, and soft tissue changes were compared using ANOVA and Tukey tests.</p><p><strong>Results: </strong>Maxillary molars exhibited significantly greater mesial angulation in Group ET compared with Groups BS and E (P = 0.02). Mandibular incisors were significantly more upright (P = 0.03) and retruded (P = 0.00) in Group BS. Group ET showed significantly greater extrusion of the mandibular incisors (P = 0.00).</p><p><strong>Conclusions: </strong>The use of buccal shelf miniscrews resulted in more upright and retruded mandibular incisors compared with treatment with Class III elastics. Intermaxillary elastics with buccal torque lower incisors and torque zero upper incisors brackets approach showed greater maxillary molar angulation and mandibular incisor extrusion.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of different rapid palatal expansion appliances on sleep, nasal airway resistance, and dentoskeletal/dentoalveolar characteristics: a prospective, randomized controlled trial.","authors":"Sertan Soylu, Ahmet Yagci, Kerem Kokoglu","doi":"10.1093/ejo/cjag030","DOIUrl":"10.1093/ejo/cjag030","url":null,"abstract":"<p><strong>Background: </strong>The effects of rapid palatal expansion (RPE) on sleep-related breathing and nasal airway resistance have been extensively investigated in prepubertal individuals; however, interpretation of these findings is confounded by growth-related changes.</p><p><strong>Objective: </strong>To evaluate and compare the effects of different RPE appliance designs (tooth-tissue supported and tooth-bone supported) on sleep-related breathing, nasal airway resistance, and dentoskeletal/dentoalveolar outcomes in postpubertal adolescents with maxillary constriction, incorporating an age-matched control group to account for nontreatment related changes.</p><p><strong>Trial design: </strong>Prospective randomized controlled trial conducted over a 1-year study period, including recruitment, intervention, and short-term follow-up.</p><p><strong>Methods: </strong></p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor.","authors":"Miltiadis A Makrygiannakis, Kostis Giannakopoulos, Eleftherios G Kaklamanos","doi":"10.1093/ejo/cjag010","DOIUrl":"10.1093/ejo/cjag010","url":null,"abstract":"","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of interceptive orthodontics: a long-term evaluation of early treatment strategies.","authors":"Sara Björns, Klara Leffler, Thomas Davidson, Anna Westerlund","doi":"10.1093/ejo/cjag022","DOIUrl":"10.1093/ejo/cjag022","url":null,"abstract":"<p><strong>Objectives: </strong>Malocclusions occur at high frequencies in children and adolescents. While early orthodontic (interceptive) interventions may reduce the need for later comprehensive treatment, their cost-effectiveness in publicly funded health systems is unclear. This study compares the cost-effectiveness of interceptive orthodontic care and fixed-appliance therapy, focusing on total costs, treatment outcomes, and resource use.</p><p><strong>Methods: </strong>A decision tree model was developed using observational data on treatment success rates, duration, and appointments to estimate resource use and costs for interceptive orthodontic care; Fixed Appliance therapy was modeled as an optimal 2-year treatment pathway. A health-care payer perspective was applied. Incremental costs and effects were calculated for four interceptive modalities: Quad Helix, Extraoral Traction (EOT), Removable Plates, and Activator appliances, as compared to fixed appliance therapy. Minimum required success rates were estimated for achieving cost-neutrality. Probabilistic sensitivity analyses (10 000 Monte Carlo simulations) and scenario analyses assessed the robustness of the results.</p><p><strong>Results: </strong>All the interceptive treatments demonstrated lower expected costs than the fixed appliance therapy, albeit with lower clinical effectiveness. Quad Helix exceeded the minimum required success rate 20% points, representing a clear margin of cost-effectiveness. Removable Plates also exceeded the minimum required success rate, but with a smaller margin of 6% points. The Activator and EOT appliances were more dependent on patient compliance and failed to meet the minimum required success rate, requiring increases of 13% and 10% points, respectively, to achieve cost-neutrality. Sensitivity analyses confirmed these patterns and underscored the importance of long-term treatment stability.</p><p><strong>Limitations: </strong>The model assumed a 100% success rate for fixed appliances and relied on expert opinion for long-term stability parameters, given the limited availability of relapse data.</p><p><strong>Conclusions: </strong>In the publicly funded dental care context studied, the use of Quad Helix and removable plates in publicly funded health-care systems appears to be cost-effective. Activator and EOT appliances should be used selectively. The study also contributes a transparent, adaptable modeling framework that can incorporate locally relevant costs and future long-term outcome data, supporting use in other publicly funded settings.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereophotogrammetry facial changes following hyrax-type and differential maxillary expanders: a randomized clinical trial.","authors":"João Gabriel Rando Poiani, Rodrigo Teixeira, Silvio Augusto Bellini-Pereira, Camila Massaro, Daniela Garib","doi":"10.1093/ejo/cjag006","DOIUrl":"10.1093/ejo/cjag006","url":null,"abstract":"<p><strong>Background: </strong>Rapid maxillary expansion (RME) is a common orthopedic intervention in mixed dentition. Evaluating facial soft tissue changes is important to understand its functional and esthetic implications.</p><p><strong>Objective: </strong>To compare facial soft tissue changes following RME using the Expander with Differential Opening (EDO) and the Hyrax-type (HT).</p><p><strong>Materials and methods: </strong>This single- center, two-arm parallel randomized clinical involved twenty-two patients aged 6-11 years with posterior crossbites, who were randomly assigned to two treatment groups. In the EDO group, anterior and posterior screws were activated ½ turn twice a day reaching 10.4 and 7.2 mm, respectively. In the HT group, conventional Hyrax was activated ½ turn twice daily until reaching 7.2 mm. Both appliances were maintained for 6 months. The primary outcome was the change in the nasal base width. Secondary outcomes included five additional facial measurements. Stereophotogrammetry was performed at pre-expansion (T1), immediately post-expansion (T2), and 6 months post-expansion (T3) for both treatment groups. Randomization used a computer-generated 1:1 allocation with sealed opaque envelopes. Although double blinding was not possible, image analyses were blinded to timepoints. Intergroup and interphase changes were analyzed using two-way ANOVA with repeated measures. The comparison of RME groups and the control group was performed using ANOVA and Tukey tests (P < 0.05).</p><p><strong>Results: </strong>The EDO group consisted of 11 patients (3 males, 8 females), with a mean age of 9.45 years. The HT group included 11 patients (4 males, 7 females) with a mean age of 9.35 years. Both type of expanders increased the nasal base width, with no significant difference between groups. A partial relapse of nasal width was observed during retention in the EDO group. The EDO group showed an increase in intercanthal width after RME. Both expanders showed a similar increase in labial intercommissural width and facial heights after expansion, with stability in the retention period.</p><p><strong>Conclusions: </strong>Both expanders increased the nasal base width and the labial intercommissural width. The EDO showed a partial relapse of nasal base width during retention. Soft tissues changes after RME in children were negligible with both types of expanders.</p><p><strong>Harms: </strong>No harms were observed.</p><p><strong>Trial registration: </strong>This trial protocol was registered by the Brazilian Clinical Trials Registry (ReBEC) under the number: RBR-2pd4s4q.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of unilateral nasal obstruction and occlusal bite-raising on mandibular condylar development in growing rats.","authors":"Yaosen Chen, Ikuo Yonemitsu, Shuntaro Iwaki, Takashi Ono","doi":"10.1093/ejo/cjag019","DOIUrl":"10.1093/ejo/cjag019","url":null,"abstract":"<p><strong>Background: </strong>Unilateral nasal obstruction (UNO) alters mandibular condylar growth, while bite-raising increases mechanical loading on the temporomandibular joint (TMJ). Hypoxia induced by UNO may exacerbate TMJ osteoarthritis (TMJOA)-like changes associated with occlusal disturbances during growth, and understanding their combined effects is clinically relevant. This study aimed to investigate whether UNO and bite-raising synergistically contribute to TMJ osteoarthritis (TMJOA)-like changes in growing rats.</p><p><strong>Methods: </strong>Twenty-four 4-week-old male Wistar rats were randomly divided into four groups: control, bite-raising (iOVD; 2-mm composite resin on the upper molars), UNO (complete left nostril sutured), and combined group (iOVD + UNO). Micro-CT was used to assess mandibular morphology and trabecular structure. Histological and immunohistochemical analyses were performed to evaluate cartilage degeneration, bone remodeling, and extracellular matrix changes. Gene expression levels of HIF-1α, IL-1β, IL-6, NF-κB, TGF-β1, and Postn were analyzed by qPCR.</p><p><strong>Results: </strong>At 9 weeks, SpO2 was significantly reduced in the UNO and iOVD + UNO groups. Micro-CT revealed increased trabecular separation and decreased bone volume fraction in the iOVD + UNO group, with suppressed bone formation and enhanced resorption confirmed by TRAP/ALP staining. Histology showed cartilage degeneration and reduced proteoglycans in all experimental groups, most pronounced in the iOVD + UNO group. Immunohistochemistry demonstrated increased expression of HIF-1α, MMP-13, and Postn, and decreased type II collagen in the iOVD + UNO group. qPCR analysis revealed elevated mRNA expression of HIF-1α, IL-1β, NF-κB, and Postn in the iOVD + UNO group.</p><p><strong>Conclusion: </strong>These findings suggest that the combination of nasal obstruction and bite-raising exacerbates the disruption of cartilage homeostasis and subchondral bone remodeling in the mandibular condyle, contributing to TMJOA-like structural and biological changes in growing rats.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of cantilever arms in the protraction of mandibular molars with clear aligners: a prospective controlled study.","authors":"Omar Ghaleb, Waseem Al-Gumaei, Shangyou Wen, Xuechun Yuan, Xian He, Lu Liu, Yan Wang, Xianglong Han, Wenli Lai, Jae Hyun Park, Hu Long","doi":"10.1093/ejo/cjag007","DOIUrl":"10.1093/ejo/cjag007","url":null,"abstract":"<p><strong>Introduction: </strong>Clear aligner technique has been revolutionizing the paradigm of contemporary orthodontic practice. However, protraction of mandibular molars is deemed as one of the most challenging tooth movements with clear aligners. This study aimed to evaluate the clinical effectiveness of cantilever arms in protracting mandibular molars with clear aligners.</p><p><strong>Materials and methods: </strong>A total of 37 orthodontic aligner patients requiring molar protraction (>4 mm) were enrolled in this prospective study. These participants were allocated into either the control group (N = 19) or the cantilever group (N = 18), resulting in 25 mandibular molars in the control group and 22 molars in the cantilever group. Superimposition of pre- and post-treatment data was performed based on cone-beam computed tomography and intraoral scanning. The differences between the predicted and achieved tooth movements (mesiodistal angulation, buccolingual inclination, and molar protraction distance) were compared. The discrepancies between the predicted and achieved tooth movements (DPA) were determined.</p><p><strong>Results: </strong>Predicted and achieved tooth movements (mesiodistal angulation, buccolingual inclination and protraction distance) were significantly different for both groups (all P < 0.001), and DPAs of mesiodistal angulation (11.7 ± 4.5 vs. 19.9 ± 4.7; P < 0.0001), buccolingual inclination (21.0 ± 7.2 vs. 33.9 ± 8.9; P < 0.0001) and molar protraction distance (0.8 ± 0.4 vs. 3.6 ± 1.5; P < 0.0001) were significantly smaller in the cantilever group than in the control group. The predictability of molar protraction was significantly higher in the cantilever group (87%) than in the control group (43%) (P < 0.0001).</p><p><strong>Conclusions: </strong>Integrating the cantilever system into clear aligners can mitigate mesial and lingual tipping of mandibular molars and enhance the predictability of mandibular molar protraction.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of salivary stress-related biomarkers in children with malocclusion and risk for sleep problems and sleep-disordered breathing: a cross-sectional study.","authors":"Shugo Manase, Aiko Ito, Fumitaka Kobayashi, Kana Sakono, Saki Tanaka, Ayaka Suga, Hiroshi Tomonari","doi":"10.1093/ejo/cjag004","DOIUrl":"10.1093/ejo/cjag004","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep problems in children can affect neuroendocrine regulation and craniofacial development. Although malocclusion may contribute to airway impairment and altered growth patterns, the associations between sleep-related symptoms and physiological stress markers remain unclear. This study examined salivary stress-related biomarkers and craniofacial morphology in children with malocclusion who were at elevated risk for sleep problems and sleep-disordered breathing (SDB).</p><p><strong>Materials and methods: </strong>Seventy-five children aged 7-12 years completed the Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES). Children with total scores ≥80 were classified as high risk for general sleep problems, and those with SDB subscale scores ≥10 as high risk for SDB. Unstimulated saliva was analysed for oxytocin, melatonin, cortisol, and chromogranin A. Lateral cephalograms were evaluated for 34 variables. Statistical analyses included Shapiro-Wilk, t-tests or Mann-Whitney U-tests, and Pearson's or Spearman's correlations (P < .05).</p><p><strong>Results: </strong>Fourteen children (18.7%) were classified as high risk for general sleep problems and 38 (50.7%) as high risk for SDB. Oxytocin concentration was lower in the high-risk sleep problems group (P = .041) and correlated negatively with JSQ-ES total score (ρ = -0.250). No biomarker differences were observed by SDB risk. Children at high risk for sleep problems showed a greater mandibular plane angle, while higher SDB scores were associated with anteroposterior skeletal discrepancies.</p><p><strong>Conclusions: </strong>Children at elevated risk for general sleep problems showed reduced salivary oxytocin and greater vertical skeletal divergence, whereas those at elevated SDB risk exhibited anteroposterior craniofacial differences without biomarker alterations.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interceptive orthodontics in practice: a 5-year population-based study.","authors":"Anna Westerlund, Sara Waldenstrom, Emilia Karttunen, Frida Lindström, Maja Oscarson, Khadija Rezaee, Rahaf Safar, Jennifer To, Sara Bjorns, Klara Leffler","doi":"10.1093/ejo/cjaf113","DOIUrl":"10.1093/ejo/cjaf113","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the scope and short-term outcomes of interceptive orthodontic treatment delivered by general dental practitioners (GDPs) under the supervision of specialist orthodontists within a publicly funded healthcare system.</p><p><strong>Subjects and methods: </strong>This retrospective cohort study included all patients aged ≤18 years who received publicly funded interceptive orthodontic treatment in Region Västra Götaland, Sweden, during 2020-2024; the pediatric population (0-18 years) was approximately 400 000. In total, 22 000 cases were identified from electronic records. Analyses focused on four appliances: Activator, Extraoral Traction, Quad Helix, and Removable Plate. Detailed outcome assessment was performed for all cases from year 2020 (n = 4400), with extraction of age, sex, treatment indication, treatment duration, number of visits, and appliance-specific outcomes.</p><p><strong>Results: </strong>In total, 21 946 treatments were registered over 5 years. The most common appliances were Removable Plates (n = 10 511), Activators (n = 6455), Quad Helix (n = 3164), and Extraoral Traction (n = 1816). On average, 4389 interceptive treatments were delivered annually, accounting for nearly 100 000 visits. Treatments were typically initiated in the late mixed dentition (mean age, 10.2-11.2 years; range, 8-13 years), with equal gender distribution. Mean treatment duration ranged from 11 months (Quad Helix) to 20 months (Activator). Success rates were highest for Quad Helix (82%) and Removable Plates (65%), while lower rates were recorded for Extraoral Traction (57%) and Activators (56%). Failures were mainly linked to poor compliance.</p><p><strong>Conclusion: </strong>The results from this large cohort study on interceptive orthodontics provide real-world evidence that although success rates were lower than in randomized trials, the outcomes reflect routine care conditions. The findings highlight the importance of compliance, appliance selection, and treatment timing. The dataset offers a foundation for future longitudinal evaluations of long-term outcomes and cost-effectiveness.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"48 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}