European Journal of Lipid Science and Technology最新文献

{"title":"A Comprehensive View on Oxidative Mechanisms of Vitamin A and Its Implications for Effective Formulation Strategies in Food Systems","authors":"Erwann Durand,&nbsp;Marianne De Vreese,&nbsp;Claude Aleman,&nbsp;Guillaume Cazals,&nbsp;Didier Morvan,&nbsp;Jérôme Lecomte,&nbsp;Pierre Villeneuve","doi":"10.1002/ejlt.70122","DOIUrl":"https://doi.org/10.1002/ejlt.70122","url":null,"abstract":"<div>\u0000 \u0000 <p>Vitamin A is an essential fat-soluble micronutrient widely used in food and feed sectors to combat deficiency symptoms worldwide and meet nutritional needs, yet its intrinsic oxidative instability continues to challenge product design and shelf-life. Although various delivery strategies, ranging from bulk oils to advanced encapsulation systems, have been employed, its degradation remains difficult to predict. Vitamin A is susceptible to oxygen mediated oxidation, forming epoxides, cleavage products, hydrolysis derivatives, and dimers through mechanisms influenced by environmental factors (light, heat, etc.), matrix composition, and molecular structure. While antioxidants can provide protection, their performance is highly system-dependent, and some compounds may even become pro-oxidant under certain conditions. The design of stable vitamin A formulations is hindered by an incomplete understanding of the fundamental oxidative processes. Most existing studies emphasize radical-driven propagation steps, but emerging evidence suggests that earlier, perhaps non-radical activation events, such as triplet-state excitation and electron-transfer processes leading to reactive species, may play a critical role in initiating degradation. Furthermore, the microstructural organization of formulations, molecular interactions within encapsulating systems, and the potential involvement of concerted pathways have been largely overlooked. These factors may significantly modulate vitamin A reactivity by altering molecular environments and influencing activation energy. A deeper mechanistic understanding of these oxidative initiation processes is therefore essential. Such knowledge would enable the design of next-generation formulations that stabilize vitamin A at its ground state, improving efficacy, safety, and long-term nutritional value.</p>\u0000 <p><i>Practical Applications</i>: A better understanding of how vitamin A degrades has direct practical value for the food and feed industries. By identifying not only its links to well-known radical oxidation pathways but also its early-stage activation mechanisms, manufacturers can design more effective stabilization strategies, either by improving encapsulation systems or by selecting antioxidants that remain protective rather than becoming pro-oxidant under certain conditions. Additionally, insights into how formulation structure and ingredient interactions influence vitamin A degradation can guide the development of optimized delivery matrices, such as emulsions or microcapsules, tailored to specific products. Applying this knowledge helps extend shelf life, maintain nutritional value, and reduce economic losses due to degradation. It also supports the creation of safer, more reliable fortified foods, ensuring that populations at risk of deficiency receive consistent and effective vitamin A intake over time.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stearoyl-CoA Desaturase 1 Activity Index and Expression in Breast Cancer Subclasses","authors":"Hamidreza Feizi,&nbsp;Zohreh Sanaat,&nbsp;Masoud Darabi,&nbsp;Ashraf Fakhrjoo,&nbsp;Maghsoud Shaaker,&nbsp;Kobra Velaei,&nbsp;Majid Montazer Bavil Olyayi,&nbsp;Amir Mehdizadeh,&nbsp;Kadijeh Abbasi","doi":"10.1002/ejlt.70123","DOIUrl":"https://doi.org/10.1002/ejlt.70123","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer cells in the tumor microenvironment face difficulties in obtaining nutrients. SCD1, an important enzyme that converts saturated fatty acids to MUFAs, exhibits increased activity index in cancers, including breast cancer, indicating the role of SCD1 in tumor growth. BC cell lines were cultured in standard conditions for 72 h. The tissue samples were also immersed in the RNA-later solution, and after harvesting the cells and tissue samples, the expression and activity index of SCD1 was analyzed using quantitative PCR and gas liquid chromatography, respectively. MCF7 cell line showed higher SCD1 expression compared to MDA-MB-231 (250-fold, <i>p</i> &lt; 0.0001) and SK-BR3 (83-fold, <i>p</i> &lt; 0.0001) cell lines. SCD1 expression was also significantly elevated in luminal tissue samples compared with HER2-positive (4.9-fold, <i>p</i> &lt; 0.0001) and triple-negative (2-fold, <i>p</i> = 0.01) BC subtypes. SCD1 activity index in both MCF7 and MDA-MB-231 cell lines was 2.10 and 2.09, respectively, and was significantly higher compared to the SK-BR3 cell line (1.27, <i>p</i> = 0.04 for both). Triple negative tissue samples (9.93 ± 4.93) also showed the highest SCD1 activity index compared to luminal samples (3.93 ± 2.4, <i>p</i> = 0.0002) and HER2 positive samples (5.43 ± 3.44, <i>p</i> &gt; 0.05). Data showed a higher capacity of the luminal subgroup to convert SFAs into MUFAs through the activity of the SCD1 enzyme. It seems that the high activity index in the triple negative subgroup is the result of the high entry of lipids from the extracellular environment. These data demonstrate the potential for SCD1 to be a metabolic vulnerability and a treatment target in certain BC subtypes.</p>\u0000 <p><b>Practical applications</b>: This research highlights SCD1 as a potential therapeutic target in breast cancer, specifically luminal and triple-negative breast cancer. Increased SCD1 activity is a substantial contributor to tumor growth in breast cancer by either converting saturated to monounsaturated fatty acids or by using extracellular lipids. If SCD1 can be targeted, it will likely inhibit cancer cell metabolism while leaving normal cells alone, providing a more selective therapeutic modality of treatment. Inhibitors, in particular, are needed for triple-negative breast cancer patients, where effective therapies are extremely limited. We also suggest measuring SCD1 expression levels in patients to inform personalized treatment plans, potentially leading to improved patient outcomes by matching metabolic vulnerabilities with specific targeted treatment plans.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive View on Oxidative Mechanisms of Vitamin A and Its Implications for Effective Formulation Strategies in Food Systems","authors":"Erwann Durand,&nbsp;Marianne De Vreese,&nbsp;Claude Aleman,&nbsp;Guillaume Cazals,&nbsp;Didier Morvan,&nbsp;Jérôme Lecomte,&nbsp;Pierre Villeneuve","doi":"10.1002/ejlt.70122","DOIUrl":"https://doi.org/10.1002/ejlt.70122","url":null,"abstract":"<div>\u0000 \u0000 <p>Vitamin A is an essential fat-soluble micronutrient widely used in food and feed sectors to combat deficiency symptoms worldwide and meet nutritional needs, yet its intrinsic oxidative instability continues to challenge product design and shelf-life. Although various delivery strategies, ranging from bulk oils to advanced encapsulation systems, have been employed, its degradation remains difficult to predict. Vitamin A is susceptible to oxygen mediated oxidation, forming epoxides, cleavage products, hydrolysis derivatives, and dimers through mechanisms influenced by environmental factors (light, heat, etc.), matrix composition, and molecular structure. While antioxidants can provide protection, their performance is highly system-dependent, and some compounds may even become pro-oxidant under certain conditions. The design of stable vitamin A formulations is hindered by an incomplete understanding of the fundamental oxidative processes. Most existing studies emphasize radical-driven propagation steps, but emerging evidence suggests that earlier, perhaps non-radical activation events, such as triplet-state excitation and electron-transfer processes leading to reactive species, may play a critical role in initiating degradation. Furthermore, the microstructural organization of formulations, molecular interactions within encapsulating systems, and the potential involvement of concerted pathways have been largely overlooked. These factors may significantly modulate vitamin A reactivity by altering molecular environments and influencing activation energy. A deeper mechanistic understanding of these oxidative initiation processes is therefore essential. Such knowledge would enable the design of next-generation formulations that stabilize vitamin A at its ground state, improving efficacy, safety, and long-term nutritional value.</p>\u0000 <p><i>Practical Applications</i>: A better understanding of how vitamin A degrades has direct practical value for the food and feed industries. By identifying not only its links to well-known radical oxidation pathways but also its early-stage activation mechanisms, manufacturers can design more effective stabilization strategies, either by improving encapsulation systems or by selecting antioxidants that remain protective rather than becoming pro-oxidant under certain conditions. Additionally, insights into how formulation structure and ingredient interactions influence vitamin A degradation can guide the development of optimized delivery matrices, such as emulsions or microcapsules, tailored to specific products. Applying this knowledge helps extend shelf life, maintain nutritional value, and reduce economic losses due to degradation. It also supports the creation of safer, more reliable fortified foods, ensuring that populations at risk of deficiency receive consistent and effective vitamin A intake over time.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Eur. J. Lipid Sci. Technol.","authors":"","doi":"10.1002/ejlt.70124","DOIUrl":"https://doi.org/10.1002/ejlt.70124","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stearoyl-CoA Desaturase 1 Activity Index and Expression in Breast Cancer Subclasses","authors":"Hamidreza Feizi,&nbsp;Zohreh Sanaat,&nbsp;Masoud Darabi,&nbsp;Ashraf Fakhrjoo,&nbsp;Maghsoud Shaaker,&nbsp;Kobra Velaei,&nbsp;Majid Montazer Bavil Olyayi,&nbsp;Amir Mehdizadeh,&nbsp;Kadijeh Abbasi","doi":"10.1002/ejlt.70123","DOIUrl":"https://doi.org/10.1002/ejlt.70123","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer cells in the tumor microenvironment face difficulties in obtaining nutrients. SCD1, an important enzyme that converts saturated fatty acids to MUFAs, exhibits increased activity index in cancers, including breast cancer, indicating the role of SCD1 in tumor growth. BC cell lines were cultured in standard conditions for 72 h. The tissue samples were also immersed in the RNA-later solution, and after harvesting the cells and tissue samples, the expression and activity index of SCD1 was analyzed using quantitative PCR and gas liquid chromatography, respectively. MCF7 cell line showed higher SCD1 expression compared to MDA-MB-231 (250-fold, <i>p</i> &lt; 0.0001) and SK-BR3 (83-fold, <i>p</i> &lt; 0.0001) cell lines. SCD1 expression was also significantly elevated in luminal tissue samples compared with HER2-positive (4.9-fold, <i>p</i> &lt; 0.0001) and triple-negative (2-fold, <i>p</i> = 0.01) BC subtypes. SCD1 activity index in both MCF7 and MDA-MB-231 cell lines was 2.10 and 2.09, respectively, and was significantly higher compared to the SK-BR3 cell line (1.27, <i>p</i> = 0.04 for both). Triple negative tissue samples (9.93 ± 4.93) also showed the highest SCD1 activity index compared to luminal samples (3.93 ± 2.4, <i>p</i> = 0.0002) and HER2 positive samples (5.43 ± 3.44, <i>p</i> &gt; 0.05). Data showed a higher capacity of the luminal subgroup to convert SFAs into MUFAs through the activity of the SCD1 enzyme. It seems that the high activity index in the triple negative subgroup is the result of the high entry of lipids from the extracellular environment. These data demonstrate the potential for SCD1 to be a metabolic vulnerability and a treatment target in certain BC subtypes.</p>\u0000 <p><b>Practical applications</b>: This research highlights SCD1 as a potential therapeutic target in breast cancer, specifically luminal and triple-negative breast cancer. Increased SCD1 activity is a substantial contributor to tumor growth in breast cancer by either converting saturated to monounsaturated fatty acids or by using extracellular lipids. If SCD1 can be targeted, it will likely inhibit cancer cell metabolism while leaving normal cells alone, providing a more selective therapeutic modality of treatment. Inhibitors, in particular, are needed for triple-negative breast cancer patients, where effective therapies are extremely limited. We also suggest measuring SCD1 expression levels in patients to inform personalized treatment plans, potentially leading to improved patient outcomes by matching metabolic vulnerabilities with specific targeted treatment plans.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Eur. J. Lipid Sci. Technol.","authors":"","doi":"10.1002/ejlt.70124","DOIUrl":"https://doi.org/10.1002/ejlt.70124","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148103390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148080058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148074770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}