European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Prenatal diagnosis and molecular cytogenetic analyses of a rare 17q12 microdeletion and 17q11.2 microduplication family with normal phenotype","authors":"Weihua Tian ,&nbsp;Qi Xia ,&nbsp;Xian He ,&nbsp;Pei Leng","doi":"10.1016/j.ejogrb.2025.114023","DOIUrl":"10.1016/j.ejogrb.2025.114023","url":null,"abstract":"<div><h3>Background</h3><div>Copy number variants (CNVs) are an important source of normal and pathogenic genome variations. Microdeletion of chromosome 17q12 results in structural or functional abnormalities in the kidney and urethra, type 5 diabetes (MODY5), and neurodevelopmental or neuropsychiatric disorders. Microduplication of 17q11.2 are less well-characterized but have been associated with variable clinical presentations, including autism spectrum disorder (ASD), developmental delay, and mild dysmorphic features.</div><div>Case presentation: In this research, a 29-year-old woman (gravida 1, para 0) underwent amniocentesis at 22 weeks’ gestation following the detection of bilateral hyperechogenic fetal kidneys on prenatal ultrasound. Notably, her husband has a medical history of congenital ichthyosis type 10, a genetic condition that warranted further genetic investigation.</div></div><div><h3>Results</h3><div>Copy number variation sequencing (CNV-seq) from this family revealed a 1.46-Mb microdeletion on chromosome 17q12 and a 640-kb microduplication on chromosome 17q11.2 of the fetus, a 640-kb microduplication on chromosome 17q11.2 of the father. Trio whole-exome sequencing (WES) analysis revealed that the father carried compound heterozygous mutations in the pathogenic gene associated with congenital ichthyosis type 10, while the fetus was identified as a heterozygous carrier of one of these mutations.</div></div><div><h3>Conclusion</h3><div>We provide a detailed description of the phenotype in a rare family with 17q12 microdeletion, 17q11.2microduplication and congenital ichthyosis type 10. Combination of karyotype analysis, CNV-seq, WES, prenatal ultrasound and genetic counselling is helpful for the prenatal diagnosis of chromosomal microdeletions/microduplications and pathogenic gene variants.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114023"},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of preoperative urinary tract infection on perioperative outcomes following benign hysterectomy","authors":"Laura Douglass ,&nbsp;Sarah Ashmore ,&nbsp;Jinxuan Shi ,&nbsp;Jessica Dai ,&nbsp;Hannah Ryles ,&nbsp;Iris Burgard ,&nbsp;Margaret G. Mueller","doi":"10.1016/j.ejogrb.2025.114019","DOIUrl":"10.1016/j.ejogrb.2025.114019","url":null,"abstract":"<div><h3>Introduction</h3><div>Preoperative urinary tract infection (UTI) is associated with adverse surgical outcomes in certain populations.</div></div><div><h3>Objective</h3><div>To determine the impact of preoperative UTI on 30-day postoperative complications in patients undergoing benign hysterectomy.</div></div><div><h3>Study Design</h3><div>A retrospective cohort study using the 2014 to 2021 American College of Surgeons National Surgical Quality Improvement Program database. Surgeries were identified using CPT codes and surgical indications were classified according to ICD 9 and 10 codes. Preoperative UTI was defined as any patient with a symptomatic UTI who had not started or was currently receiving antibiotic treatment at the time of surgery. The primary outcome was any postoperative complication within 30-days of surgery. Standard group comparisons were performed using Chi −square and Fisher’s exact test for categorical variables and Mann-Whitney <em>U</em> test for continuous variables.</div></div><div><h3>Results</h3><div>Patients with a preoperative UTI were older (p &lt; 0.001) with higher rates of American Society of Anesthesiologists (ASA) physical status class 3 or 4 (p &lt; 0.001) compared to patients without a UTI. Vaginal hysterectomy (p &lt; 0.001) and surgical indication of pain or prolapse (p &lt; 0.001) was higher in the UTI cohort. Operative time (p &lt; 0.001) and reoperation rate (p &lt; 0.001) was also higher in the UTI cohort. Total 30-day postoperative complications were 5.6 % amongst all patients undergoing benign hysterectomy. Preoperative UTI was associated with a higher 30-day postoperative complication rate compared to patients without a UTI (8.2 % verses 5.6 %, p = 0.03). On multivariable logistic regression, preoperative UTI no longer remained associated with any 30-day perioperative complication after controlling for potential confounding variables. However, patients with a UTI were at almost 4 times higher odds (aOR 3.98) of readmission.</div></div><div><h3>Conclusion</h3><div>While preoperative UTI was not associated with an increased risk of postoperative complication, patients with a preoperative UTI ahead of benign hysterectomy were at increased odds of readmission within 30 days.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114019"},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral versus intravenous antibiotic prophylaxis before obstetric and gynecological surgical interventions: A randomized clinical trial","authors":"Hatem Abo Elftooh Awaga ,&nbsp;Yasmeen Tharwat Anwar,&nbsp;Abdou Saeed Ait-Allah,&nbsp;Amr Othman Abdelkareem","doi":"10.1016/j.ejogrb.2025.114020","DOIUrl":"10.1016/j.ejogrb.2025.114020","url":null,"abstract":"<div><h3>Objective</h3><div>The current study was conducted to compare the efficacy of prophylactic intravenous versus oral (Cephradin) for the prevention of surgical site infections (SSI) in Obstetric and Gynecological interventions.</div></div><div><h3>Methods</h3><div>A randomized clinical trial was carried out on 230 patients fulfilling the eligibility criteria between 1st October 2023 and 31st July 2024, including pregnant women who were approached prior to their delivery and non-pregnant women who were approached prior to their intended interventions. (group A) 116 patients received oral antimicrobial prophylaxis, while (group B) 114 patients received intravenous antimicrobial prophylaxis. Furthermore, all included patients received oral antibiotics postoperatively (oral cephradine 500 mg/ 12 h for 7 days). Patients were evaluated twice; the 1st assessment was done 1 week, while the 2nd assessment was done a month after the intervention.</div></div><div><h3>Results</h3><div>SSI rate was 14 % CI (0.07–0.20) in the oral group compared to 13 % CI (0.07–0.20) in the intravenous group after one week with no significant difference in between (p = 0.84). However, the SSI rate was 5.5 % CI (0.02–0.11) in the oral group compared to 6.3 % CI (0.02–0.12) in the intravenous group after one month of the intervention, with no significant difference in between (p = 0.78).</div></div><div><h3>Conclusion</h3><div>The current study showed that oral antibiotic prophylaxis before obstetric and gynecological interventions seems to be safe, easy, practical, cheap, and as effective as parenteral antibiotic prophylaxis in the prevention of SSI. However, more randomized trials with larger sample sizes are needed to pave the way for replacing parenteral with oral antibiotic chemoprophylaxis.</div><div><strong>Trial registration</strong>: The study was approved by the Sohag Ethical Committee, Faculty of Medicine, with IRB number (Soh-Med-23-09-05MS) and was registered on clinical <span><span>trial.gov</span><svg><path></path></svg></span> with T.R.N (NCT06255652).</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114020"},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency cerclage in delayed interval delivery of a DCDA twin pregnancy – A case commentary","authors":"Federica Fernicola ,&nbsp;Sabrina Cozzolino ,&nbsp;Elettra Salmoiraghi ,&nbsp;Sara Ornaghi ,&nbsp;Anna Locatelli","doi":"10.1016/j.ejogrb.2025.114017","DOIUrl":"10.1016/j.ejogrb.2025.114017","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114017"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of second trimester uterine artery doppler using uterine artery score in routine prenatal care in Switzerland","authors":"Sara Ardabili,&nbsp;Markus Hodel,&nbsp;Ines Kaufmann,&nbsp;Stefanie Pelikan,&nbsp;Joachim Kohl","doi":"10.1016/j.ejogrb.2025.114002","DOIUrl":"10.1016/j.ejogrb.2025.114002","url":null,"abstract":"<div><h3>Objective</h3><div>The role of 2nd trimester uterine artery Doppler (UtAd) remains unclear and its implementation varies greatly. Aim of this study was to determine whether 2nd trimester UtAd interpreted with uterine artery score (UAS), a score combining PI and notching in both UtA, is useful in an unselected population in routine care.</div></div><div><h3>Methods</h3><div>We retrospectively calculated the UAS in 503 unselected singleton pregnancies with 2nd trimester scan at 20–24 weeks between 09/2021 and 08/2023 and later delivery in our department and analysed its relationship with perinatal outcome.</div></div><div><h3>Results</h3><div>With UAS &gt; 2 there was a significant increase in adverse perinatal outcome such as hypertension/PE (OR 7.88), SGA (OR 6.82), preterm birth (OR 5.51) and placental abruption (OR 6.89). In contrast, no significant difference was found when comparing UAS 0, 1 and 2. In general, NPV for adverse outcomes were high while PPV were low. In 50 % of SGA-fetuses and 33 % of cases with hypertension/PE in UAS 3–4, the woman had no risk factor.</div></div><div><h3>Conclusion</h3><div>Routine 2nd trimester UtAd is useful in all pregnancies as it can identify additional patients without a pre-existing risk who generally would not be eligible for intense surveillance but still develop PE or SGA later. Further, due to the high NPV, UtAd qualifies as a rule-out tool for adverse outcome even in high-risk pregnancies. To standardise its interpretation, UAS with a cut-off at 2 seems to be a suitable tool for an unselected population. In case of UAS 3–4 a more intense surveillance program should be offered.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114002"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Isolated Maternal Hypothyroxinemia with Gestational Diabetes Mellitus and Perinatal Outcomes","authors":"Hao-Yi Jia ,&nbsp;Peng-Yuan He ,&nbsp;Cong Lu ,&nbsp;Meng-Jie Zhou ,&nbsp;Shi-Tong Zhan ,&nbsp;Hui-Qin Zhong ,&nbsp;Xian-Ming Xu","doi":"10.1016/j.ejogrb.2025.114015","DOIUrl":"10.1016/j.ejogrb.2025.114015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine the association between isolated maternal hypothyroxinemia (IMH) during the first and second trimesters and the risk of gestational diabetes mellitus (GDM), as well as its association with adverse perinatal outcomes.</div></div><div><h3>Methods</h3><div>The study included 2,741 pregnant women who visited the obstetric outpatient clinic at Shanghai General Hospital and underwent routine obstetric examinations between January 2020 and June 2021. Participants diagnosed with IMH in the first trimester were categorized as H1(+), while those without as H1(−). Similarly, those diagnosed with IMH in the second trimester were categorized as H2(+), and those without as H2(−). Based on these classification, four groups were formed: group A H1(−) H2(−), (n = 1,886); group B H1(+) H2(−), (n = 99); group C H1(−) H2(+), (n = 613); and group D H1(+) H2(+), (n = 143). Retrospective analysis was performed to examine clinical data, including pregnancy complications, across all four groups.</div></div><div><h3>Results</h3><div>The incidence of GDM was significantly higher in groups B, C, and D compared to group A (all <em>p</em> &lt; 0.001), with the following trend: group D &gt; group C &gt; group B &gt; group A. Specifically, group D exhibited the highest incidence of GDM [n% = 93.01 %, <em>p</em>3 &lt; 0.001]). Logistic regression analysis, adjusted for confounding factors identified IMH during the first trimester, IMH during the second trimester, and persistent IMH across both trimesters as significant risk factors for GDM. Notably, the risk of GDM in cases of persistent IMH was 73.97 times higher than the normal risk (<em>aOR</em> = 73.97, <em>p</em> &lt; 0.001). The study also found that isolated maternal hypothyroxinemia (IMH) was significantly associated with adverse perinatal outcomes.</div></div><div><h3>Conclusion</h3><div>IMH during either the first or second trimester, and particularly persistent IMH across both trimesters, is strongly associated with a higher risk of GDM and insulin resistance. Our findings highlight the importance of monitoring and managing IMH during pregnancy to mitigate the risk of adverse perinatal outcomes. Early intervention may improve both maternal and neonatal health.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114015"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time perception in shoulder dystocia management; a secondary analysis of the prospective cohort simulation SAFE study","authors":"Dimitrios Papoutsis ,&nbsp;Paraskevi Klazoglou ,&nbsp;George Valasoulis ,&nbsp;Chara Tzavara","doi":"10.1016/j.ejogrb.2025.114016","DOIUrl":"10.1016/j.ejogrb.2025.114016","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to explore and quantify the potential improvement and retention of time perception in a simulated childbirth complicated by shoulder dystocia with use of high-fidelity simulation.</div></div><div><h3>Methods</h3><div>This was a secondary analysis of the previously conducted prospective cohort SAFE study. Registered midwives and final year Midwifery students were invited to attend a one-day workshop in 6-monthly intervals at the University of Western Macedonia in Greece between October 2021-November 2022. There was a 30-minute initial assessment, a 30-minute theoretical and hands-on training, and a 30-minute post-training assessment on shoulder dystocia management. We identified the actual-time and the self-reported perceived-time of delivery at the start and end of each workshop and measured the difference between them to determine if there was any improvement and retention of time perception through consecutive workshops.</div></div><div><h3>Results</h3><div>The baseline workshop recruited 101 participants with mean age of 26.7 ± 9.8 years (range:20–59), of which 53 participated at the 6 month and 33 at the 12 month workshop. There was a significant improvement in time perception by approximately 34.8 % at the end of the baseline workshop, which was retained after 6 and 12 months. 80.2 % of participants experienced a ‘time-distortion effect’ towards the same direction and felt that the simulated delivery lasted longer than the actual time recorded by the birthing simulator. Those who were more competent at the start of the baseline workshop demonstrated a better time perception.</div></div><div><h3>Conclusions</h3><div>The skill of time perception in shoulder dystocia can be improved and retained through simulation training.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114016"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence regarding: Twomey S, Hunter A, Mahomed K. Introducing a Modified Grenoble Classification for induction of labour with an audit at a regional maternity unit in Australia. Eur J Obstet Gynecol Reprod Biol. 2025;306:168–171","authors":"David Desseauve ,&nbsp;Alexandre Buisson ,&nbsp;Didier Riethmuller","doi":"10.1016/j.ejogrb.2025.114008","DOIUrl":"10.1016/j.ejogrb.2025.114008","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114008"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyloric web: A rare and hidden cause of isolated polyhydramnios","authors":"Maria Cheung,&nbsp;Dermot Wildes,&nbsp;Patrick Williams,&nbsp;James Walshe,&nbsp;Karen Flood","doi":"10.1016/j.ejogrb.2025.114011","DOIUrl":"10.1016/j.ejogrb.2025.114011","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114011"},"PeriodicalIF":2.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of proteinuria assessment methods and their association with maternal-fetal outcomes in preeclampsia","authors":"Shipra Sonkusare ,&nbsp;Lipika Prabhu ,&nbsp;Prasanna Shetty ,&nbsp;Prashant Naik ,&nbsp;Niranjan Gopal ,&nbsp;Silky Kumari","doi":"10.1016/j.ejogrb.2025.114010","DOIUrl":"10.1016/j.ejogrb.2025.114010","url":null,"abstract":"<div><h3>Introduction</h3><div>Preeclampsia is a multisystem, progressive disorder in pregnancy characterized by new-onset hypertension and proteinuria. Early detection and treatment are crucial to prevent adverse maternal and fetal outcomes. The current gold standard for proteinuria assessment is the 24-hour urine protein test. This study aimed to compare the assessment of proteinuria using the dipstick test and urine protein-to-creatinine ratio (UPCR) against the 24-hour urine protein test in women with preeclampsia.</div></div><div><h3>Methodology</h3><div>This prospective analytical study was conducted over 18 months in tertiary care centers in southern and central India. Pregnant women after 20 weeks of gestation with preeclampsia were included. Proteinuria assessments using the dipstick test and UPCR were compared with the 24-hour urine protein test.</div></div><div><h3>Results</h3><div>A positive linear relationship was observed between UPCR and 24-hour urine protein levels. Adverse maternal and fetal outcomes were more frequent in women with UPCR &gt; 0.3, although the association was statistically significant only in women having preeclampsia with severe features. The best cut-off of UPCR to predict 24-hour urine protein &gt; 300 mg/dl in women with preeclampsia was 1.29, and it showed 100 % sensitivity and 58.2 % specificity.</div></div><div><h3>Conclusion</h3><div>The spot urine protein:creatinine ratio is not only quick and accurate method for measuring proteinuria in preeclampsia, but also very sensitive and quite specific, showing a strong correlation with the 24-hour urine protein test. The best cut-off value to predict significant proteinuria in our study was 1.29.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114010"},"PeriodicalIF":2.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}