European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Cervical cancer in young women: Does age impact survival in cervical cancer?","authors":"Guilherme S. Accorsi ,&nbsp;Jeferson R. Zanon ,&nbsp;Marcelo H. dos Santos ,&nbsp;Ana Carla F. Ubinha ,&nbsp;Ronaldo Schmidt ,&nbsp;Renato Moretti-Marques ,&nbsp;Glauco Baiocchi ,&nbsp;Cristiano de Pádua Souza ,&nbsp;Carlos E.M. da Cunha Andrade ,&nbsp;Ricardo dos Reis","doi":"10.1016/j.ejogrb.2024.12.003","DOIUrl":"10.1016/j.ejogrb.2024.12.003","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To evaluate the oncology outcomes in cervical cancer patients aged 25 years or younger and compare them with those in older patients.</div></div><div><h3>Methods</h3><div>Cervical cancer patients were retrospectively analyzed and divided into two groups: young patients (≤25 years) and older patients (&gt;25 years). For each young patient, two controls were selected from the database of cervical cancer patients aged over 25 years, matched by FIGO stage, treatment, and histologic type.</div></div><div><h3>Results</h3><div>A total of 138 patients were included, 46 patients aged 25 years or younger and 92 patients aged over 25 years. Of young patients, stage III was the most common, with 21 (45.5 %) patients, while stages I, II and IV occurred in 12 (26.2 %), 8 (17.4 %) and 5 (10.9 %) patients, respectively. The 5-year RFS (75 % and 73 %; P = 0.91) and 5-year OS (60 % and 67 %; P = 0.45) were not significantly different between the groups. After multivariate analysis age had no significant impact on OS (HR 1.25, 95 % CI 0.68–2.30; P = 0.46) or RFS (HR 0.95, 95 % CI 0.43–2.10; P = 0.91).</div></div><div><h3>Conclusions</h3><div>Cervical cancer patients aged 25 years or younger did not present a worse OS and RFS compared to patients aged over 25 years.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"305 ","pages":"Pages 67-74"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in the incidence of preterm births","authors":"C. MacBride,&nbsp;L. Creswell,&nbsp;E. McNamee,&nbsp;S.W. Lindow,&nbsp;M.P. O’Connell","doi":"10.1016/j.ejogrb.2024.11.014","DOIUrl":"10.1016/j.ejogrb.2024.11.014","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the influence of the season of conception, and the season of birth on the incidence of preterm birth (PTB) and neonatal outcomes.</div></div><div><h3>Study design</h3><div>This is a single center, retrospective cohort study of singleton births that took place in The Coombe Hospital in Dublin, Ireland, between January 2013 and December 2022. A comprehensive database was analyzed to determine the incidence of PTB per season of conception and season of birth. Overall neonatal outcomes were reported and stratified per the occurrence of PTB or term birth.</div></div><div><h3>Results</h3><div>Following exclusions, 76,988 births were analyzed. Women who conceived in winter between December-February had significantly lower rates of PTBs when compared to other seasons (5.4 % vs 6.5 % (spring) vs 5.6 % (summer) and 5.4 % (autumn), p &lt; 0.001). When considering only spontaneous preterm labor, this trend persists, with most women experiencing spontaneous PTBs conceiving during spring (6.7 % vs 5.5 % (winter) vs 5.7 % (summer) vs 5.5 % (autumn), p = 0.001). Conversely, women who gave birth in December-February had significantly higher rates of premature births when compared to other seasons (6.2 vs 5.8, 5.5 %. and 5.5 %, p &lt; 0,01). PTBs of spontaneous onset were highest between December and February, however no statistical significance was found (6.2 % vs 6.1 % (spring), 5.7 % (summer) and 5.4 % (autumn), p = 0.13). No significant variation in maternal risk factors or neonatal outcomes were identified between the seasons.</div></div><div><h3>Conclusions</h3><div>This study has shown that there is a seasonal variation in the incidence of preterm births in this Irish-based cohort. A low prevalence of PTB was demonstrated when conceptions occurred in the winter months. However, there was a greater incidence of preterm births between December and February. This is suggestive that there are potential risk factors associated with seasonal patterns that may be modifiable. Further research to identify these specific risks is warranted.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"305 ","pages":"Pages 298-304"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive changes in delivery outcomes following the launch of round-the-clock labour epidural analgesia at an institution: A retrospective cohort study","authors":"Onishi Tatsuki ,&nbsp;Ryuichi Wakata ,&nbsp;Sayo Hoshino ,&nbsp;Kyomi Kasai","doi":"10.1016/j.ejogrb.2025.01.041","DOIUrl":"10.1016/j.ejogrb.2025.01.041","url":null,"abstract":"<div><h3>Background</h3><div>Emergency caesarean section is associated with maternal and foetal complications, potentially exacerbated by general anaesthesia use.</div></div><div><h3>Objective</h3><div>To determine whether labour epidural analgesia use affects caesarean section incidence.</div></div><div><h3>Study design</h3><div>This retrospective single-centre cohort study involved women in labour (n = 11,792) between 1 January 2015 and 31 December 2021. The primary outcome was caesarean section incidence, determined from electronic medical records; secondary outcome was caesarean section incidence change over time.</div></div><div><h3>Results</h3><div>Of 5849 deliveries from 1 August 2018, when round-the-clock labour epidural analgesia became available, until 31 December 2021, 1,433 (24.5 %) involved labour epidural analgesia. Of these, 203 (14.2 %) involved unintended caesarean section, less than that in the non-labour epidural analgesia group (22.2 %) (hazard ratio: 0.47; 95 % confidence interval [CI]: 0.41–0.55, p &lt; 0.001). Sensitivity analysis, assuming 50 % of non-labour epidural analgesia cases should have had used labour epidural analgesia, yielded a hazard ratio of 0.65 (95 %CI: 0.57–0.75, p &lt; 0.001). Propensity-score matching adjusted for possible confounders. Temporal changes in caesarean section incidence were analysed between 1 August 2018 and 31 October 2021. This passage of time explained the reduction in values for the difference-in-differences analysis by 20.5 % (95 %CI: 5.5–35.6, p = 0.007). Interrupted time series analysis revealed caesarean section incidence increased with time after round-the-clock labour epidural analgesia became available in the non-labour epidural analgesia group (p = 0.01).</div></div><div><h3>Conclusions</h3><div>Round-the-clock labour epidural analgesia use is associated with decreased caesarean section incidence, partly due to optimisation of eligibility criteria. Labour epidural analgesia use should be expanded to aid vaginal delivery and improve maternal well-being.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 91-97"},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does pregnancy affect decisions regarding management of suspected adnexal torsion?","authors":"Vadim Sheiman ,&nbsp;Elad Preuss ,&nbsp;Atara De Porto ,&nbsp;Moty Pansky ,&nbsp;Oshri Barel ,&nbsp;Eran Barzilay","doi":"10.1016/j.ejogrb.2025.01.052","DOIUrl":"10.1016/j.ejogrb.2025.01.052","url":null,"abstract":"<div><h3>Objective</h3><div>Decision regarding surgery in cases of suspected adnexal torsion are usually more complex when the patient is pregnant, balancing the risks of surgery to the mother and the fetus with risks of permanent ovarian damage. The aim of this study was to examine whether pregnancy affects decisions regarding management of suspected adnexal torsion cases.</div></div><div><h3>Methods</h3><div>This was a retrospective study conducted at a single medical center. A total of 174 women underwent a laparoscopic surgery due to suspected adnexal torsion during the study’s period. All ultrasound examinations were performed by certified ultrasound technicians or physicians. The pregnant women group was compared to non pregnant group.</div></div><div><h3>Results</h3><div>A total of 37 women were pregnant and 137 were not pregnant. We found that pregnant women presented more commonly with a maximal pain level (VAS 10), vomiting and peritoneal signs compared to non-pregnant women. Women in the pregnancy group were operated on significantly faster than women in the non-pregnant group (5.1 h, IQR 3–7.7, vs 9.6 h, IQR 4.6–20.6, respectively, p = 0.001). However, using a Cox regression model accounting also for extreme pain (VAS = 10), vomiting and peritoneal signs, pregnancy was not found to be a significant independent factor that reduced time to surgery. Furthermore, we showed an ovarian torsion incidence of 81.1 % among pregnant women that underwent surgery compared to only a 39.7 % in the non-pregnant group (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Pregnant women with suspected adnexal torsion that are referred for surgery are more likely to be found with adnexal torsion and to be operated on earlier than non-pregnant women.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 105-108"},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and sociodemographic distribution of endometriosis symptoms and indicators in Denmark","authors":"Marie Josiasen ,&nbsp;Eeva-Liisa Røssell ,&nbsp;Tong Zhu ,&nbsp;Anna Melgaard ,&nbsp;Lucky Saraswat ,&nbsp;Andrew W. Horne ,&nbsp;Karina Ejgaard Hansen ,&nbsp;Dorte Rytter","doi":"10.1016/j.ejogrb.2025.01.051","DOIUrl":"10.1016/j.ejogrb.2025.01.051","url":null,"abstract":"<div><h3>Introduction</h3><div>Endometriosis is characterized by a range of non-specific symptoms which may contribute to the significant delay in diagnosis. Knowledge about the distribution of endometriosis symptoms across different geographical regions as well as other sociodemographic factors could add knowledge and guide initiatives to reduce this underdiagnosis. This study aims to explore how the prevalence of endometriosis symptoms and indicators are linked to the different sociodemographic factors.</div></div><div><h3>Study design</h3><div>The study used data from the CYKLUS-survey; a women’s health survey sent to 63,199 Danish women aged 16 to 51 in 2023. Self-reported information on endometriosis symptoms and indicators was linked to Danish register data on sociodemographic factors. Age-standardized prevalence of six endometriosis symptoms and indicators were estimated for each of the nine different regions of residence and for the whole country. In addition, logistic regression analysis was used to estimate the association between sociodemographic factors and the six endometriosis symptoms and indicators.</div></div><div><h3>Results</h3><div>11,407 women were included in the study. Age-standardized prevalence of symptoms showed little variation across Danish regions. However, younger age, lower socioeconomic status, and non-Danish origin were found to be associated with higher prevalences, and higher education was found to be associated with lower prevalences.</div></div><div><h3>Conclusion</h3><div>No major regional differences in endometriosis symptoms and indicators were found. However, associations were found between several sociodemographic factors and endometriosis symptoms and indicators, suggesting disparities in the burden of symptoms. These findings call for further investigation into factors causing these disparities in Denmark.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 109-120"},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143221941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new angiogenic classification with PlGF and sFlt-1.","authors":"Valentina Giardini, Marco Casati, Patrizia Vergani, Anna Locatelli","doi":"10.1016/j.ejogrb.2025.01.053","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.01.053","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative application of high-intensity focused ultrasound combined with endometrial thermal balloon ablation in the treatment of adenomyosis: A cohort study","authors":"Zhuoting Jin ,&nbsp;Ligang Wang ,&nbsp;Dan Wang ,&nbsp;Qianwen Zheng ,&nbsp;Xuemei Qing ,&nbsp;Yong Zhang","doi":"10.1016/j.ejogrb.2025.01.049","DOIUrl":"10.1016/j.ejogrb.2025.01.049","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of high-intensity focused ultrasound (HIFU) combined with endometrial thermal balloon ablation (TBEA) for treating adenomyosis-related hypermenorrhagia.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 120 patients diagnosed with adenomyosis-related hypermenorrhagia. Patients were divided into three groups: the HIFU combined with TBEA group (HIFU + TBEA, 34 cases), the HIFU combined with gonadotropin-releasing hormone agonist and intrauterine levonorgestrel intrauterine system (HIFU + GnRH-a + LNG-IUS, 51 cases) group and the HIFU (35 cases) group. Efficacy and safety were assessed using the pictorial blood loss assessment chart (PBAC), dysmenorrhea scores evaluated by the Numerical Rating Scale (NRS), quality of life measured by the Uterine Fibroid Symptom and Quality of Life scale (UFS-QOL), reintervention rates, success rates, satisfaction, and adverse effects at pretreatment and 1, 3, 6, 9, and 12 months posttreatment.</div></div><div><h3>Results</h3><div>The HIFU + TBEA group showed significantly greater reductions in PBAC scores at 6, 9, and 12 months compared to the HIFU + GnRH-a + LNG-IUS group, and consistently lower scores than the HIFU group at all follow-up points. No significant differences in NRS scores or reintervention rates were observed between groups. Additionally, the HIFU + TBEA group reported higher UFS-QOL scores at 6 and 12 months posttreatment and greater satisfaction at 12 months posttreatment. Its success rate exceeded that of the HIFU group but was comparable to the HIFU + GnRH-a + LNG-IUS group. Serious adverse reactions were rare across all groups.</div></div><div><h3>Conclusion</h3><div>HIFU combined with TBEA demonstrates good efficacy and safety, providing an effective long-term treatment option for adenomyosis-related hypermenorrhagia in patients without fertility needs.</div></div><div><h3>Synopsis</h3><div>Evaluating HIFU + TBEA as an effective long-term treatment for adenomyosis-related hypermenorrhagia in patients without fertility needs.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 134-141"},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143221750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of elinzanetant in vasomotor symptoms associated with menopause: A meta-analysis of randomized controlled trials","authors":"Milene Vitória Sampaio Sobral ,&nbsp;Paula Rocha ,&nbsp;Livia Kneipp Rodrigues ,&nbsp;Abner Mácola Pacheco Barbosa ,&nbsp;Naila Camila da Rocha ,&nbsp;Clara de Andrade Pontual Peres ,&nbsp;Claudio Lucca Lima Furtado ,&nbsp;Danieli Pereira da Silva ,&nbsp;Marina Ayabe Gomes de Moraes ,&nbsp;Veronica Alvarez-Galiana","doi":"10.1016/j.ejogrb.2025.01.050","DOIUrl":"10.1016/j.ejogrb.2025.01.050","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of elinzanetant compared to placebo in patients experiencing vasomotor symptoms (VMS) associated with menopause.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Embase, and Cochrane databases identified randomized clinical trials (RCTs) comparing elinzanetant and placebo in patients with menopause-related VMS. Statistical analyses pooled mean difference (MD) and risk ratio (RR) with 95% confidence intervals (CI) using R Studio 4.3.2. Pre-specified outcomes included frequency and intensity of VMS, quality of life, and sleep disturbance.</div></div><div><h3>Results</h3><div>This <em>meta</em>-analysis included three randomized clinical trials reporting data on 995 patients, with 551 receiving elinzanetant. The mean age ranged from 54.4 to 55.6 years. Elinzanetant significantly reduced VMS frequency (MD −3.09; 95 % CI −4.18 to −2.01; I² = 0 %) and intensity (MD −0.32; 95 % CI −0.43 to −0.21; I² = 39 %). Improvements in quality of life were demonstrated by reduced scores on the Menopause-Specific Quality of Life Questionnaire (MD −0.46; 95 % CI −0.63 to −0.30; I² = 35 %) and better sleep quality measured by the Patient-Reported Outcomes Measurement Information System Sleep Disturbance – Short Form 8b (MD −4.65; 95 % CI −5.56 to −3.73; I² = 0 %). The incidence of adverse events was similar between groups (RR 1.11; 95 % CI 0.99 to 1.25; I² = 35 %).</div></div><div><h3>Conclusion</h3><div>Elinzanetant reduces the frequency and intensity of VMS and enhances quality of life and sleep quality in patients with menopause-related symptoms. Its safety profile is comparable to placebo.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 142-147"},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143221889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal associations between dietary habits and age at natural menopause: A two-sample diet-wide Mendelian randomization study","authors":"Chung-Chih Liao ,&nbsp;Chun-I Lee ,&nbsp;Jung-Miao Li","doi":"10.1016/j.ejogrb.2025.01.047","DOIUrl":"10.1016/j.ejogrb.2025.01.047","url":null,"abstract":"<div><h3>Background</h3><div>Menopause, the natural cessation of menstrual cycles, marks a significant phase in a woman’s life and is associated with various health outcomes. While previous observational studies have suggested associations between dietary habits and the age at natural menopause (ANM), their findings have been inconsistent and often confounded, making it difficult to infer causality. This study aims to assess the causal relationships between dietary habits and ANM using a two-sample diet-wide Mendelian randomization (MR) approach.</div></div><div><h3>Methods</h3><div>The study utilized data from 445,779 participants in the UK Biobank and genetic data from 201,323 women in the ReproGen Consortium. We selected single nucleotide polymorphisms associated with 38 dietary habits as instrumental variables for MR analysis. We applied MR methods, including inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode, to assess associations. Sensitivity analyses, including heterogeneity tests, pleiotropy assessments, and leave-one-out analyses, were conducted to validate the robustness of the findings.</div></div><div><h3>Results</h3><div>Beer or cider consumption and spread on bread consumption were linked to an earlier onset of menopause. Oily fish consumption showed a potential association with a later onset of menopause, though this was not significant after false discovery rate correction. Sensitivity analyses confirmed the robustness of these findings, indicating no significant pleiotropy and stable effect estimates.</div></div><div><h3>Conclusion</h3><div>This study provides evidence that certain dietary habits may influence the timing of menopause. These insights underscore the importance of diet in reproductive aging and warrant further investigation to better understand these relationships and their underlying mechanisms.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 84-90"},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effects of menstruation/menopause on the association between the COVID-19 pandemic related post-traumatic stress disorder symptoms and loneliness in Japanese female workers: A cross-sectional study","authors":"Kumi Hirokawa ,&nbsp;Tetsuro Noda ,&nbsp;Kyoko Tokunaga","doi":"10.1016/j.ejogrb.2025.01.048","DOIUrl":"10.1016/j.ejogrb.2025.01.048","url":null,"abstract":"<div><h3>Objective</h3><div>The present study investigated the effect of menstruation/menopause symptoms on the association between post-traumatic stress disorder (PTSD) symptoms related the COVID-19 pandemic and loneliness in Japanese female workers.</div></div><div><h3>Study design</h3><div>A web survey of 530 female workers (303 pre-menopausal and 217 post-menopausal women) was conducted in February 2023, in Japan. The Japanese version of the Impact of Event Scale–Revised was used to evaluate PTSD symptoms. Symptoms of premenstrual syndrome (PMS) were investigated in 263 pre-menopausal women (mean age = 37.0 years, SD = 8.9) and 203 post-menopausal women (mean age = 57.1 years, SD = 9 0.6) were asked about menopausal symptoms.</div></div><div><h3>Main outcome measure</h3><div>The Japanese version of the three-item loneliness scale.</div></div><div><h3>Results</h3><div>The pre-menopausal women scored higher in loneliness than the post-menopausal women. However, after adjusting for age, this significant difference was attenuated. Results of multiple regression analyses showed that PMS symptoms were positively associated with loneliness in the pre-menopausal women. In comparison, both PTSD symptoms and menopause symptoms were positively associated with loneliness in post-menopausal women. There was no interaction between PMS/menopausal symptoms and PTSD symptoms in loneliness scores. The indirect effect of PMS symptoms, particularly the psychological symptoms, was associated with PTSD symptoms and loneliness in pre-menopausal women. In addition, there was a significant indirect effect of menopausal symptoms in the post-menopausal women.</div></div><div><h3>Conclusions</h3><div>When female workers were subjected to COVID-19 pandemic-related psychological stress, their menstrual and menopausal symptoms would lead to intensified loneliness, especially in pre-menopausal women.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 71-77"},"PeriodicalIF":2.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}