European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Inside Back Cover - Editors with images","authors":"","doi":"10.1016/S0301-2115(25)00205-2","DOIUrl":"10.1016/S0301-2115(25)00205-2","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"308 ","pages":"Page IBC"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Critical appraisal of “Comparison of combined oral contraceptives and dienogest for endometriosis-associated pain”’","authors":"Salvatore Caruso , Stefano Cianci , Giuseppe Caruso , Marco Iraci Sareri , Ferdinando Antonio Gulino , Marco Palumbo","doi":"10.1016/j.ejogrb.2025.113945","DOIUrl":"10.1016/j.ejogrb.2025.113945","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113945"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of endometrial nerve fibers and hormones on pain in women with endometriosis","authors":"Anton Sommar ,&nbsp;Pinar Yalcin Bahat ,&nbsp;Ipek Yildiz Özaydin ,&nbsp;Marie Bixo ,&nbsp;Torbjörn Bäckström ,&nbsp;Engin Oral ,&nbsp;Sahruh Turkmen","doi":"10.1016/j.ejogrb.2025.113950","DOIUrl":"10.1016/j.ejogrb.2025.113950","url":null,"abstract":"<div><h3>Objective</h3><div>The mechanisms behind endometriosis-related pain are not yet fully understood. To determine if there is a difference in the density of endometrial nerve fibers between women with endometriosis and healthy controls, and to explore how the density of these nerve fibers and hormone levels correlate with the severity of symptoms experienced by the women.</div></div><div><h3>Study Design</h3><div>In this case-control study, 76 women with endometriosis and 24 healthy controls were included. The patient group was divided into two subgroups: those with and without hormonal treatments. Endometrial biopsies were taken and stained to detect PGP 9.5, a nerve fiber marker. Blood samples were collected for hormone analysis. Pain symptom severity was measured using VAS and EHP30.</div></div><div><h3>Results</h3><div>Women with endometriosis had a higher density of endometrial nerve fibers than healthy controls (median [range]: 2.0 [2.0–4.0] vs. 1.0 [0.0–1.0] fibers/mm², P &lt; 0.001). This increased density was associated with more severe pain (β = 0.130 [95 % CI: 0.019, 0.240], P = 0.02). Women with endometriosis, regardless of hormone treatment, had a higher density of endometrial nerve fibers (3.0 [2.0–4.0] and 2.0 [1.0–4.0] fibers/mm², respectively) compared with healthy controls (1.0 [0.0-u1.0] fibers/mm², both P &lt; 0.001). The density was not significantly different between those receiving and not receiving hormone treatment. The allopregnanolone/progesterone ratio was greater in women with endometriosis not receiving hormone treatment (0.002 [0.001–0.004]) than in healthy controls (0.001 [0.000–0.005]) and women receiving hormone treatment (0.001 [0.000–0.006], P = 0.02 and 0.001, respectively). A greater allopregnanolone/progesterone ratio was associated with more severe pain (β = 20.662 [95 % CI: 0.202, 41.121], P = 0.048), but hormone levels (estrogen, progesterone, and allopregnanolone) were not associated with endometrial nerve fiber density.</div></div><div><h3>Conclusion</h3><div>Women with endometriosis have a higher nerve fiber density in the endometrium, linked to more severe pain, regardless of hormone treatment. Increased progesterone metabolism to allopregnanolone may be a target for managing endometriosis pain.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113950"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing urban dance and functional fitness for postmenopausal women: A randomized clinical trial protocol","authors":"Julia Beatriz Bocchi Martins,&nbsp;Ana Rafaela Amaral da Rocha,&nbsp;Danielly Yani Fausto,&nbsp;Emily da Silva,&nbsp;Giulian da Silva,&nbsp;Gleyson Patrick Pinheiro,&nbsp;Adriana Coutinho de Azevedo Guimarães","doi":"10.1016/j.ejogrb.2025.113936","DOIUrl":"10.1016/j.ejogrb.2025.113936","url":null,"abstract":"<div><h3>Introduction</h3><div>Physical exercise is a non-pharmacological treatment that can bring positive changes to menopausal women experiencing physiological and hormonal changes leading to various physical and psychological symptoms. This study introduces the xxxxxxx Project protocol, aiming to compare the effects of Urban Dance and Functional Fitness with a control group on the physical and psychological well-being of postmenopausal women.</div></div><div><h3>Methods</h3><div>This study outlines a protocol for a three-arm randomized clinical trial involving two interventions (Urban Dance and Functional Fitness) lasting 12 weeks. The participants will be women in early postmenopause, aged between 40 and 59 years, assigned to three groups: (1) Urban Dance Intervention Group, (2) Functional Fitness Intervention Group, and (3) Control Group. Both interventions will consist of two weekly sessions lasting 60 min each. The outcomes to be assessed include physical aspects (body mass index, fat percentage, waist circumference, muscle strength, cardiorespiratory fitness, bone densitometry, sleep quality, urinary incontinence, sexual function, and follicle-stimulating hormone) as well as psychological aspects (stress, cognition, mood state, depressive symptoms, and anxiety). Data collection and analysis will be conducted during pre- and post-intervention periods.</div></div><div><h3>Discussion</h3><div>The study is proposed with the aim of expanding the evidence related to the effects of different types of physical exercise in reducing and/or stopping symptoms resulting from menopause. The hypothesis is that women who perform the types of physical exercise will significantly improve the symptoms investigated when compared to those in the control group, thus expanding the possibilities of non-pharmacological therapies to assist the work of health professionals, favoring the physical and psychological aspects of this population.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113936"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristic and risk factors for post-operative complications in women undergoing laparoscopy myomectomy","authors":"Reut Rotem ,&nbsp;Neta Jacobowitz Bodner ,&nbsp;Miri Erenberg ,&nbsp;Yael Reicher ,&nbsp;Zehava Yohay ,&nbsp;Adi Y. Weintraub","doi":"10.1016/j.ejogrb.2025.113949","DOIUrl":"10.1016/j.ejogrb.2025.113949","url":null,"abstract":"<div><h3>Objective</h3><div>To assess clinical characteristic and risk factors for post-operative complications in women undergoing laparoscopic myomectomy using the Clavien-Dindo classification system.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted at Soroka University Medical Center, Beer Sheva, Israel, between 2010 and 2020, including women who underwent laparoscopic myomectomy. Postoperative adverse events were classified using the Clavien-Dindo system. The study population was divided into two groups: those with complications (Clavien-Dindo classification ≥ 1) and those without complications (Clavien-Dindo classification = 0). Risk factors were compared between the groups and analyzed for statistical significance using univariate and multivariate logistic regression.</div></div><div><h3>Results</h3><div>A total of 111 women who underwent laparoscopic myomectomy were included. Of these, 26 experienced complications (study group) and 85 did not (comparison group); all complications were minor. Women in the study group had a higher incidence of pre-operative symptoms (76.9 % vs. 55.3 %). Additionally, the duration of surgery was significantly longer in the study group (137 min vs. 97 min, p &lt; 0.01), and estimated blood loss was higher, with more frequent use of anti-adhesive agents. There was no significant difference in preoperative anemia between the groups. Estimated blood loss &gt; 100 mL was found to be independently associated with complications (aOR 4.4, 95 % CI 1.5–12.5).</div></div><div><h3>Conclusion</h3><div>Laparoscopic myomectomy is a safe and effective surgical option for women, with a low rate of minor complications. Although longer surgeries and increased blood loss were associated with complications, the overall risk remains minimal. Proper identification of risk factors such as pre-operative symptoms and intraoperative blood loss can help optimize patient outcomes. Future research should further explore the relationship between anemia and surgical outcomes, as no significant differences in anemia were observed in this study.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113949"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent low-grade smears and inadequate colposcopy: Challenges in cervical screening","authors":"Mr Junaid Rafi","doi":"10.1016/j.ejogrb.2025.113948","DOIUrl":"10.1016/j.ejogrb.2025.113948","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113948"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from the EGOI-PCOS patient survey: Diagnosis, treatment, and quality of life according to Italian PCOS patients","authors":"Vito Cosimo Carriero ,&nbsp;Gianpiero Forte ,&nbsp;Simona Dinicola ,&nbsp;Mario Montanino Oliva ,&nbsp;Gaia Al Mudarris ,&nbsp;Vittorio Unfer","doi":"10.1016/j.ejogrb.2025.113947","DOIUrl":"10.1016/j.ejogrb.2025.113947","url":null,"abstract":"<div><h3>Background</h3><div>Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder; however, the current guidelines do not adequately address the metabolic aspect. By gathering patients’ perspectives, this survey investigates potential issues with the current diagnostic process to identify key points that need addressing in the future.</div></div><div><h3>Method</h3><div>A survey comprising of 49 multiple-choice question was distributed to members of the Italian PCOS community <em>NoiPCOS</em>, including topics such as demographics, PCOS diagnosis experience, symptom management, quality of life, and access to information about PCOS.</div></div><div><h3>Results</h3><div>769 women aged 18–40 responded to the survey. 72.2% of responders were employed and perceived their socio-economic status as “good”. PCOS diagnosis was primarily obtained in adolescence (35.1%) or late adolescence (33.6 %), with the most common symptoms being polycystic ovaries (85.8%), irregular menses (80.4%), and hirsutism (64.1%). Moreover, PCOS symptoms were seen to severely impact the mental health for 64.7% of responders. Treatments prescribed for PCOS were diet (49.5%), exercise (46.9%), metformin (27.6%), hormonal contraception (26.4%), and myo-inositol and D-chiro-inositol (25.2%). When accessing information about PCOS, women often relied on unofficial sources (i.e. internet sources) rather guidance from their physician.</div></div><div><h3>Conclusion</h3><div>Findings of this survey highlight that a thorough update of PCOS diagnostic criteria is required, which should consider the endocrine and metabolic aspects of the syndrome. Such revision should enable a more accurate, precise diagnosis that translates to effective therapy. Finally, any reconsideration of the PCOS guidelines should increase the perceived reliability by patients of medical care, reducing the communication gap between specialists and patients.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113947"},"PeriodicalIF":2.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinagolide vaginal ring for reduction of endometriotic lesions: Results from the QLARITY trial","authors":"Antonio Pellicer ,&nbsp;Hugh S. Taylor ,&nbsp;Angel Alberich-Bayarri ,&nbsp;Yan LIU ,&nbsp;Michael Gamborg ,&nbsp;Kathryn E. Barletta ,&nbsp;Philippe Pinton ,&nbsp;Patrick W. Heiser ,&nbsp;Yu Z. Bagger","doi":"10.1016/j.ejogrb.2025.113946","DOIUrl":"10.1016/j.ejogrb.2025.113946","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the effectiveness of quinagolide vaginal ring on reducing total lesion size in endometrioma, deep infiltrating endometriosis (DIE), and adenomyosis, as assessed using high-resolution MRI and imaging biomarkers.</div></div><div><h3>Methods</h3><div>QLARITY was a randomized, double-blind, placebo-controlled, phase 2 trial. Patients aged 18–45 years with endometrioma, DIE, and/or adenomyosis were randomized to quinagolide or placebo and monitored for four menstrual cycles. The primary endpoint was reduction in total lesion size. Secondary endpoints were pain reduction, changes in prolactin, changes in menstrual cycle, bleeding patterns, and safety. Exploratory analyses identified MRI-derived perfusion and diffusion-weighted imaging biomarkers.</div></div><div><h3>Results</h3><div>Of the 67 included subjects, 35 received quinagolide vaginal ring and 32 received placebo. No significant differences were noted between groups for the primary endpoint of reduction in lesion size. No significant differences were observed between groups in terms of patient-reported outcomes, serum prolactin levels, menstrual bleeding patterns, or adverse events. Exploratory analyses suggested lesions in the placebo group showed a greater increase in vascular permeability and worsening lesion structure.</div></div><div><h3>Conclusions</h3><div>Our primary analysis showed no significant difference between treatment groups in terms of change in total lesion size. Many patients in this study presented with advanced disease, which may be less responsive to quinagolide than highly vascularized superficial lesions, as quinagolide inhibits the VEGF signaling pathway.</div></div><div><h3>Trial Registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> NCT03749109.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113946"},"PeriodicalIF":2.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient satisfaction with two different management modalities for erratic bleeding during continuous hormone therapy for endometriosis-associated symptoms: A before-after study","authors":"Yoko Zecchini ,&nbsp;Daniela Alberico ,&nbsp;Deborah Ambruoso ,&nbsp;Chiara Pillinini ,&nbsp;Dhouha Dridi ,&nbsp;Giussy Barbara","doi":"10.1016/j.ejogrb.2025.113944","DOIUrl":"10.1016/j.ejogrb.2025.113944","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate patient satisfaction with the management of erratic bleeding during continuous hormone therapy for endometriosis using two different strategies: an active approach (tailored cycling), which involved discontinuation of the therapy; and a passive approach, which involved waiting for spontaneous resolution of the bleeding.</div></div><div><h3>Methods</h3><div>This was an observational before–after study. All patients enrolled within a previously defined time limit were instructed to adopt a passive strategy to manage erratic bleeding, while all patients enrolled after that defined time were instructed to discontinue therapy for 7 days (tailored cycling). Degree of satisfaction, characteristics of bleeding, and level of dysmenorrhoea were compared and analysed at the time of enrolment and after 6 and 12 months.</div></div><div><h3>Results</h3><div>In total, 201 patients were included in the study. Satisfaction was 29% higher among patients in the passive strategy group compared with those in the tailored cycling group; this difference was significant. No significant differences were identified for the other outcomes.</div></div><div><h3>Conclusion</h3><div>Patients may be more satisfied with the use of a passive approach to manage irregular bleeding during continuous hormone therapy for endometriosis-associated pain. All patients should be provided with comprehensive information regarding all available management strategies for unpredictable irregular bleeding. This will enable patients to make informed decisions based on their personal experience and preferences, without external pressure, thus improving compliance, adherence and, ideally, satisfaction with treatment.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113944"},"PeriodicalIF":2.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and cardiovascular factors related to carotid intima-media thickness during pregnancy: A prospective cohort study","authors":"Maia Brik ,&nbsp;Miguel Sánchez-Polán ,&nbsp;Alba Farràs ,&nbsp;Alina Hernández-Fleury ,&nbsp;Joaquin Temprado ,&nbsp;Inés Calero ,&nbsp;Teresa Higueras ,&nbsp;Cristina Silva ,&nbsp;Dingfeng Zhang ,&nbsp;Elena Carreras ,&nbsp;Ruben Barakat","doi":"10.1016/j.ejogrb.2025.113943","DOIUrl":"10.1016/j.ejogrb.2025.113943","url":null,"abstract":"<div><h3>Objective</h3><div>Cardiovascular disease continues to be the most important cause of death among women worldwide. Carotid intima-media thickness (CIMT) is a well-known indicator of cardiovascular disease. The study aims to establish associations between CIMT measurements and cardiovascular disease risk factors in pregnancy.</div></div><div><h3>Methods</h3><div>A prospective observational study including normotensive pregnant women. CIMT was measured by mode B-ultrasound in 51 women. Baseline characteristics, weight gain, SBP, DBP, uterine artery Doppler, HbA1c, lipid profile, perceived stress (PSS), anxiety symptoms (STAI) and the level of physical activity during pregnancy were recorded.</div></div><div><h3>Results</h3><div>Normal reference values (mean ± sd) for CIMT (mm) were described for 20–22 weeks (0.513 ± 0.0067), 28–30 weeks (0.504 ± 0.077) and 33–36 weeks (0.499 ± 0.059). Maternal age was correlated to CIMT (Rho Spearman = 0.392, p = 0.016). However, other variables studied such as weight gain, SBP, DBP, uterine artery Doppler, HbA1c, lipid profile, perceived stress (PSS), and anxiety symptoms (STAI) showed no correlation with CIMT measurements. CIMT was similar in active vs non-active participants (0.540 ± 0.069 vs. 0.489 ± 0.054 mm, p = 0.053). CIMT measurements did not change with gestational age (p = 0.751).</div></div><div><h3>Conclusions</h3><div>Among normotensive pregnant individuals, CIMT is associated with maternal age but remains stable across gestational age and unaffected by various cardiovascular risk factors during pregnancy.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113943"},"PeriodicalIF":2.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}