European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Adverse pregnancy outcomes as early indicators of long-term maternal atrial fibrillation: a systematic review and meta-analysis.","authors":"Pedro Gomes Batista, Ramon Huntermann, Marcela Vasconcelos Montenegro, Railla Raquel Albino Dos Santos Silva, Maria Eduarda Molinari, Larissa Araújo de Lucena, Mrunalini Dandamudi, Caroline O Fischer-Bacca, Juliana Giorgi","doi":"10.1016/j.ejogrb.2026.115491","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115491","url":null,"abstract":"<p><strong>Background: </strong>Adverse pregnancy outcomes (APOs) - including hypertensive disorders of pregnancy, preeclampsia, gestational diabetes mellitus (GDM), preterm birth, and fetal growth deviations - are emerging female-specific cardiovascular risk factors, but their association with long-term maternal atrial fibrillation (AF) remains unclear.</p><p><strong>Objective: </strong>To assess the association between APOs and subsequent AF.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane Central, and Scopus. We included population-based cohort studies comparing women with and without APOs and reporting incident maternal AF during follow-up. Time-to-event associations were synthesized, pooling hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs).</p><p><strong>Results: </strong>12 population-based cohort studies including over 11 million women were analyzed. Hypertensive disorders of pregnancy were associated with higher long-term risk of AF (HR 1.50; 95 % CI 1.38-1.62), as was preeclampsia (HR 1.45; 95 % CI 1.23-1.71). Preterm birth was also associated with increased AF risk (HR 1.29; 95 % CI 1.13-1.48). Delivery of a large for gestational age infant was associated with higher AF risk (HR 1.23; 95 % CI 1.13-1.34), whereas small for gestational age delivery showed an inverse association (HR 0.88; 95 % CI 0.80-0.97). For GDM, the association was more uncertain, with wide CIs and effect estimates suggesting an increased risk (HR 1.20; 95 % CI 0.84-1.72).</p><p><strong>Conclusion: </strong>Hypertensive and vascular pregnancy complications are associated with elevated long-term maternal AF risk. Associations for gestational diabetes and fetal growth phenotypes were heterogeneous and should be interpreted cautiously. These findings support APOs as markers of later arrhythmic vulnerability.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"327 ","pages":"115491"},"PeriodicalIF":2.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of glucagon-like peptide-1 receptor agonists versus metformin on pregnancy rates in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized trials.","authors":"Emre Kar, John Yeh, Mehtap Akın Efe, Hale Göksever Çelik, Gürkan Bozdağ, Ercan Baştu","doi":"10.1016/j.ejogrb.2026.115499","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115499","url":null,"abstract":"<p><strong>Background: </strong>PCOS-related infertility is closely linked to metabolic dysfunction. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve insulin resistance and promote weight loss in women with PCOS, but their direct effect on reproductive outcomes remains uncertain.</p><p><strong>Objectives: </strong>To evaluate whether GLP-1RA-based therapy improves pregnancy outcomes in women with PCOS.</p><p><strong>Search strategy: </strong>PubMed, Scopus, and Web of Science were searched from inception to February 2026.</p><p><strong>Selection criteria: </strong>Randomized controlled trials comparing GLP-1RA-based therapy, alone or combined with metformin, with metformin monotherapy in women with PCOS.</p><p><strong>Data collection and analysis: </strong>Two reviewers independently screened studies, extracted data, and assessed risk of bias using RoB 2. Dichotomous outcomes were pooled as odds ratios with 95% confidence intervals using a random-effects model. Certainty of evidence was rated with GRADE, and trial sequential analysis was performed.</p><p><strong>Main results: </strong>Four reports from three randomized trials (252 participants) were included. GLP-1RA-based treatment did not significantly improve overall pregnancy (OR 1.41, 95% CI 0.81-2.45), but was associated with an increase in natural pregnancy (OR 3.10, 95% CI 1.74-5.49), with no significant effect on IVF pregnancy (OR 1.01, 95% CI 0.36-2.85). TSA supported the finding for natural pregnancy, while evidence for overall pregnancy remained underpowered. Certainty of evidence was moderate for natural pregnancy and low for the other outcomes.</p><p><strong>Conclusions: </strong>GLP-1 receptor agonists show promising preliminary signals for improving spontaneous conception in women with PCOS, but the available evidence remains limited. Current evidence is insufficient to draw conclusions regarding IVF outcomes. Larger trials with standardized endpoints, including live birth, are needed.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"327 ","pages":"115499"},"PeriodicalIF":2.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic hysteroscopy and positive peritoneal cytology in endometrial cancer: The influence of tumor molecular features.","authors":"Ran Matot, Yarden Sela, Yossi Geron, Ido Givon, Gil Zeevi, Effi Yeoshoua, Ram Eitan, Nati Bor","doi":"10.1016/j.ejogrb.2026.115505","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115505","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate diagnostic hysteroscopy, mismatch repair (MMR) status, and p53 expression in relation to positive peritoneal cytology (PPC) in endometrial cancer.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of women who underwent surgical staging for histologically confirmed endometrial carcinoma at a tertiary medical centre between January 2016 and December 2024. Only patients with available peritoneal cytology were included. Clinical, pathologic, and molecular data were extracted from electronic medical records. Associations between diagnostic modality, molecular characteristics, and PPC were evaluated using univariable and multivariable analyses.</p><p><strong>Results: </strong>A total of 212 women were included, of whom 46 (21.7 %) had PPC. Endometrioid adenocarcinoma was the predominant histological subtype (69.8 %), and most tumors were FIGO stage I-II (76.9 %). On univariable analysis, PPC was significantly associated with non-endometrioid histology, deep myometrial invasion, lymphovascular space invasion, advanced-stage disease, and abnormal p53 expression. After adjustment for age, disease stage, histological subtype, and MMR status, advanced-stage disease remained independently associated with PPC (adjusted odds ratio [aOR] 7.46, 95 % CI 2.87-19.41). Hysteroscopy-based diagnosis was not independently associated with PPC (aOR 1.67, 95 % CI 0.67--4.20). Neither MMR deficiency nor abnormal p53 expression was independently associated with cytologic positivity.</p><p><strong>Conclusion: </strong>Hysteroscopy-based diagnosis was not independently associated with PPC after adjustment for clinicopathological and molecular factors. Advanced-stage disease remained independently associated with PPC. These findings add a molecular perspective to the interpretation of cytologic positivity following diagnostic hysteroscopy.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"327 ","pages":"115505"},"PeriodicalIF":2.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical management of recurrent pregnancy loss: a critical assessment of international guidelines.","authors":"Marcela Torres de Melo Cavalcante, Daniel de Sousa Sobral, Anna Sayuri Albuquerque Sawaki, Graziela Martins Bezerra Correia Férrer, Marcelo Borges Cavalcante","doi":"10.1016/j.ejogrb.2026.115501","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115501","url":null,"abstract":"<p><strong>Objective: </strong>To compare the methodological quality, evidence-grading systems, and clinical recommendations of the guidelines for recurrent pregnancy loss (RPL).</p><p><strong>Methods: </strong>This narrative review evaluated the European Society of Human Reproduction and Embryology (ESHRE), Royal College of Obstetricians and Gynaecologists (RCOG), Australasian Clinical Practice Guideline for Recurrent Pregnancy Loss (ACCEPT), and American Society for Reproductive Medicine (ASRM) guidelines. Methodological quality was assessed using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. An overall recommendation grade (A, B, or C) was assigned using a previously published complementary classification system. Evidence-grading systems, recommendation strength, and clinical recommendations were compared across the major etiological domains of RPL.</p><p><strong>Results: </strong>ESHRE and RCOG demonstrated the highest methodological quality and were classified as Grade A, whereas ACCEPT and ASRM were classified as Grade B. Heterogeneity was observed in evidence-grading systems and recommendation frameworks. ESHRE, RCOG, and ACCEPT adopted different approaches to evaluating evidence, whereas ASRM did not use a formal evidence-grading system.The guidelines differed substantially in their definitions of RPL and recommendations regarding genetic evaluation, uterine surgery, endocrine disorders, inherited thrombophilias, reproductive immunology, chronic endometritis, and unexplained RPL. Broad consensus was observed regarding antiphospholipid syndrome, uterine cavity assessment, thyroid dysfunction, lifestyle modification, and psychological support.</p><p><strong>Conclusions: </strong>RPL guidelines exhibit important methodological and clinical heterogeneity that extends beyond differences in the available evidence. Harmonization of diagnostic definitions, standardized approaches to evidence appraisal, greater transparency in consensus development, and high-quality randomized controlled trials are needed to improve and facilitate precision medicine in RPL.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"327 ","pages":"115501"},"PeriodicalIF":2.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Comparison of proteinuria assessment methods and their association with maternal-fetal outcomes in preeclampsia\" [Eur. J. Obstetr. Gynecol. Reproduct. Biol. 311 (2025) 114010].","authors":"Shipra Sonkusare, Lipika Prabhu, Prasanna Shetty, Prashant Naik, Niranjan Gopal, Silky Kumari","doi":"10.1016/j.ejogrb.2026.115447","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115447","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":" ","pages":"115447"},"PeriodicalIF":2.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Anti-Müllerian hormone is a predictor of medium-term cumulative live birth following in vitro fertilization/intracytoplasmic sperm injection: A retrospective study\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 272 (2022) 220-225].","authors":"Dang Kien Nguyen, Sean O'Leary, Moustafa Abdelhafez Gadalla, Bronnie Roberts, Helen Alvino, Kelton P Tremellen","doi":"10.1016/j.ejogrb.2026.115356","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115356","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":" ","pages":"115356"},"PeriodicalIF":2.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern to \"Evaluation of depression and sleep disorders in the preoperative and postoperative period in stage 4 endometriosis patients\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 264 (2021) 254-258].","authors":"Mustafa Goksu, Pinar Kadirogullari, Kerem Doga Seckin","doi":"10.1016/j.ejogrb.2026.115162","DOIUrl":"10.1016/j.ejogrb.2026.115162","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115162"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Pre-emptive analgesia by nerve stimulator guided pudendal nerve block for posterior colpoperineorrhaphy\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 163/2 (2012) 200-203].","authors":"Mohamed Taha Ismail, Nagat S Elshmaa","doi":"10.1016/j.ejogrb.2026.115163","DOIUrl":"10.1016/j.ejogrb.2026.115163","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115163"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern to \"The utility of tumor markers and neutrophil lymphocyte ratio in patients with an intraoperative diagnosis of mucinous borderline ovarian tumor\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 196 (2016) 60-63].","authors":"Kerem Doga Seckin, Mehmet Fatih Karslı, Burak Yucel, Melih Bestel, Dogukan Yıldırım, Emel Canaz, Ozgur Akbayır","doi":"10.1016/j.ejogrb.2026.115161","DOIUrl":"10.1016/j.ejogrb.2026.115161","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115161"},"PeriodicalIF":1.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern to \"Bladder function after sacrospinous hysteropexy and vaginal wall repair in women with uterovaginal prolapse\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 224 (2018) 170-174].","authors":"Waleed A Sayed Ahmed, Omima T Taha, Mostafa A Hamdy, Zakia M Ibrahim, Amal M Elshahat","doi":"10.1016/j.ejogrb.2026.115029","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115029","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"321 ","pages":"115029"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}