European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Development and validation of a body image scale for Polycystic Ovary Syndrome","authors":"Yingzhu Huang ,&nbsp;Zhengjie Wang ,&nbsp;Zhongsheng Hu ,&nbsp;Lialian Wang ,&nbsp;Lili Yu ,&nbsp;Yuanjia Hu ,&nbsp;Lichang Sun ,&nbsp;Jialing Yang ,&nbsp;Xun Lei","doi":"10.1016/j.ejogrb.2025.113977","DOIUrl":"10.1016/j.ejogrb.2025.113977","url":null,"abstract":"<div><h3>Background</h3><div>Research on body image in women with polycystic ovary syndrome (PCOS) has increased due to its significant physical and psychological impact.The aim of this study was to develop and validate the Polycystic Ovary Syndrome Body Image Scale (PCOSBIS).</div></div><div><h3>Design</h3><div>An instrument development and validation study was completed in the following three phases: (Ⅰ) the generation and revision of the item, (Ⅱ) the preliminary reduction of items and construct validation (Ⅲ) the psychometric evaluation of the scale.</div></div><div><h3>Methods</h3><div>Data were collected from April to September in 2024. An item pool was generated through literature review, Delphi expert consultation, and interviews with 21 PCOS patients. The instrument-verification phase surveyed 400 PCOS patients from three tertiary general hospitals. Exploratory factor analysis and confirmatory factor analysis were conducted, and criterion validity, internal consistency, and test–retest reliability were assessed.</div></div><div><h3>Results</h3><div>The PCOSBIS was comprised six dimensions with 23 items, accounting for 70.79 % of the variance. Confirmatory factor analysis showed a good model fit. PCOSBIS exhibited strong reliability (α = 0.92) and test–retest stability. As expected, the PCOSBIS is positively correlated with the Connor-Davidson Resilience Scale (CD-RISC) and Medical Outcomes Study Short-Form 36-Item Health Survey (SF-36). Analysis of 400 patients’ score revealed a mean score of 48.60 ± 10.85, with the lowest score in ‘Physiological Function Satisfaction.’</div></div><div><h3>Conclusion</h3><div>PCOSBIS exhibits robust psychometric properties, making it a valuable tool for assessing body image disturbances in PCOS patients.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113977"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upfront and interval debulking surgery in advanced/metastatic endometrial cancer in the era of molecular classification","authors":"Fabio Caiazzo ,&nbsp;Francesco Raspagliesi ,&nbsp;Valentina Chiappa ,&nbsp;Simone Bruni ,&nbsp;Lorenzo Ceppi ,&nbsp;Giorgio Bogani","doi":"10.1016/j.ejogrb.2025.113958","DOIUrl":"10.1016/j.ejogrb.2025.113958","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate oncologic outcomes and prognostic factors of the different molecular subtypes of advanced/metastatic endometrial cancer treated with primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS).</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of patients with endometrial cancer and peritoneal carcinomatosis and/or “bulky” nodal metastasis surgically treated between September 2010 and February 2024. Survival outcomes were compared across four molecular subtypes (p53-mutant, MMR-deficient, NSMP, and POLE-mutant) and surgical approaches.</div></div><div><h3>Results</h3><div>Overall, 51 patients with stage IIIC-IVB endometrial cancer underwent surgical treatment. Thirty-six (70.5 %) patients had PDS followed by adjuvant chemotherapy, while fifteen (29.5 %) received NACT followed by IDS. Most patients in both groups had FIGO stage IVB disease: 24 (66.6 %) in the PDS group and 14 (93.3 %) in the IDS group. Complete cytoreduction was achieved in 83.3 % of the PDS group and 40 % of the IDS group, with no significant differences in postoperative morbidity between the groups. Molecular profiling data were available for most patients, with p53-mutated tumors being the most common subtype (36.1 % in the PDS group and 46.6 % in the IDS group), followed by MMR-deficient tumors (30.5 % in the PDS group and 26.6 % in the IDS group). The type of surgical approach (PDS vs. IDS) did not show a statistically significant correlation with disease-free survival (p = 0.523, log-rank test) or overall survival (p = 0.123, log-rank test). Similarly, molecular classification did not predict patient outcomes in terms of disease-free survival (p = 0.397, log-rank test) or overall survival (p = 0.797, log-rank test).</div></div><div><h3>Conclusions</h3><div>Oncologic outcomes for patients with advanced endometrial cancer remain poor. Neoadjuvant chemotherapy continues to be a viable treatment option for patients with unresectable disease. A personalized approach to neoadjuvant therapy, taking into account histologic and molecular profiles, may improve survival outcomes in this patient population.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113958"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics in pregnancy and group B streptococcus colonization: A multicentric, randomized, placebo-controlled, double-blind study with a focus on vaginal microbioma","authors":"Daniela Menichini ,&nbsp;Francesco De Seta ,&nbsp;Salvatore Andrea Mastrolia ,&nbsp;Irene Cetin ,&nbsp;Anastasia Carafa ,&nbsp;Susanna Santagni ,&nbsp;Claudio Foschi ,&nbsp;Matteo Cerboneschi ,&nbsp;Serena Smeazzetto ,&nbsp;Isabella Neri ,&nbsp;Fabio Facchinetti","doi":"10.1016/j.ejogrb.2025.113976","DOIUrl":"10.1016/j.ejogrb.2025.113976","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the feasibility and effects of the use of probiotics in pregnancy, starting in the third trimester, on rectovaginal colonization of group B streptococcus (GBS) in women at low obstetric risk.</div></div><div><h3>Methods</h3><div>A multicentre, randomized, placebo-controlled, double-blind, parallel-group study was conducted in three tertiary hospitals in northern Italy and included low-risk pregnant women. The intervention consisted of oral administration of two capsules of probiotics or placebo from 30 weeks of pregnancy until 37 weeks of pregnancy. The primary outcome was GBS colonization, evaluated with rectovaginal swabs. In a subgroup, selected at random, changes in the vaginal microbiome after treatment administration were evaluated using 16S Metagenomic Sequencing Library Preparation sequencing and analysis.</div></div><div><h3>Results</h3><div>In total, 267 pregnant women were randomized to receive probiotics (<em>n</em> = 133) or placebo (<em>n</em> = 134). The two groups were similar at baseline. After treatment, no differences were found in the rates of positive rectovaginal swabs (<em>p</em> = 0.24) and antibiotic administration (<em>p</em> = 0.27). Only one case of postpartum fever (&gt;38 °C) was found in the placebo group. Labour and delivery outcomes and neonatal outcomes were similar in both groups. Analysis of the vaginal microbiota showed that the relative abundance of <em>Lactobacillus</em> spp. was not modified significantly by the probiotics, but the relative abundance of <em>Gardnerella</em> spp. decreased significantly (3.6 ± 7.9 vs 5.5 ± 10.2; <em>p</em> = 0.03). Interestingly, the relative abundance of <em>Lactobacillus</em> spp. reduced significantly in women who subsequently presented with partial rupture of membranes (46.9 ± 43.6 vs 77.7 ± 24.9; <em>p</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>Although the clinical outcomes were unaffected, administration of probiotics led to favourable changes in vaginal microbiota. It remains to be established how this effect could be translated into clinical advantage.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113976"},"PeriodicalIF":2.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of extended expectant management in preterm premature rupture of membrane between 32 and 34 weeks of pregnancy-A randomization control trial","authors":"Deepti Ghosh ,&nbsp;Pramila Jena ,&nbsp;Partha Sarathi Sahu ,&nbsp;Deepti Damayanty Pradhan ,&nbsp;Jyochnamayi Panda ,&nbsp;Bandita Panda","doi":"10.1016/j.ejogrb.2025.113971","DOIUrl":"10.1016/j.ejogrb.2025.113971","url":null,"abstract":"<div><h3>Background</h3><div>Cases of preterm premature rupture of membranes (PPROM) occur in approximately 3 % of pregnancies and are a significant contributor to preterm birth and its associated complications. Traditionally expectant management followed by delivery at 34 weeks is the recommended standard for treatment of PPROM but recent evidence suggests that extended expectant management in selected cases improves the pregnancy outcome. Thus the study aims to compare the feto-maternal outcome in PPROM cases between traditional management (delivery at 34 weeks) and extended expectant management (delivery at 36 weeks)</div></div><div><h3>Methodology</h3><div>Women presenting to labor emergency with leakage due to membrane rupture at 32 to 34 weeks of gestation were randomly assigned as per CONSORT guidelines into two groups, group A (n = 72) with traditional treatment and group B (n = 72) with extended expectant management. The pregnancy outcomes and feto-maternal outcomes of both groups were analyzed by appropriate statistical tools.</div></div><div><h3>Results</h3><div>Out of a total of 144 cases with comparable baseline characteristics, 72 patients in group A had the mean gestational age at delivery was 34.02 weeks and in group B it was 35.02 weeks. There is no significant increase in chorioamnionitis and other maternal morbidity in group B. The mean birth weight was significantly higher in group B patients<strong>.</strong> The median duration of NICU stay, need for mechanical ventilation and complications like neonatal jaundice and necrotizing enterocolitis were significantly lower (p-value &lt; 0.05) in Group B as compared to Group A reflecting a better perinatal outcome.</div></div><div><h3>Conclusion</h3><div>Extended expectant management can safely be considered in PPROM cases till 36 weeks based on the timing of onset of PPROM without the fear of increased risk of maternal chorioamnionitis and adverse neonatal outcomes.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113971"},"PeriodicalIF":2.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of intrapartum cardiotocography using wireless transabdominal fetal ECG and electrohysterography: A prospective cohort","authors":"Catarina Reis-de-Carvalho ,&nbsp;Maria Carvalho-Afonso ,&nbsp;Cristiana Marinho-Soares ,&nbsp;Inês David ,&nbsp;Diogo Ayres-de-Campos","doi":"10.1016/j.ejogrb.2025.113955","DOIUrl":"10.1016/j.ejogrb.2025.113955","url":null,"abstract":"<div><h3>Aim</h3><div>To compare patient and staff acceptability of intrapartum cardiotocographic (CTG) monitoring using wireless transabdominal fetal ECG (TAfECG) plus electrohysterography (EH) with conventional wireless CTG, using Doppler ultrasound (US) and tocodynamometry (TOCO).</div></div><div><h3>Methods</h3><div>This was a prospective observational study, carried out in a tertiary care university hospital, between January and June 2023. A total of 264 labouring women with singleton pregnancies at term, in cephalic presentation, and more than 18 years of age, undergoing wireless CTG monitoring with wireless TAfECG + EH or US + TOCO were evaluated. A 10-point Likert scale patient satisfaction questionnaire was given to all participants in the early postpartum period. A second questionnaire evaluated 264 opinions of healthcare professionals regarding the two methods.</div></div><div><h3>Results</h3><div>Women reported more favourable satisfaction scores with TAfECG + EH regarding comfort of use, ease and freedom of movement, skin irritation, and ability to rest in labour. Healthcare professionals reported a more favourable evaluation of TAfECG + EH regarding patient comfort during application, signal loss with mobility, ease of interpretation of contraction signals, and ease of interpretation of FHR signals in the 1st stage. Conversely, this technology was found to be more difficult to apply and to take more time to obtain an interpretable FHR signal. These aspects were evaluated more favourably after healthcare professionals had gained more experience with the method (p &lt; 0.0001). The likelihood of women recommending the technique to others was similar between TAfECG + EH (81.2 %) and US + TOCO (81.1 %). Changing the CTG acquisition method occurred in 33.8 % of TAfECG + EH group and 9.1 % of US + TOCO group.</div></div><div><h3>Conclusions</h3><div>Wireless CTG monitoring with TAfECG + EH is well accepted by both labouring women and healthcare professionals, it is judged to be more comfortable for women than US + TOCO, and to allow greater mobility. However, in about a third of the cases it needs to be changed to another acquisition method during labour.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113955"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectus muscle reapproximation at cesarean delivery: a randomized controlled trial","authors":"Berna Aslan Cetin ,&nbsp;Fitnat Topbas ,&nbsp;Kübra Keskin Toptas ,&nbsp;Merve Konal ,&nbsp;Gökalp Senol","doi":"10.1016/j.ejogrb.2025.113966","DOIUrl":"10.1016/j.ejogrb.2025.113966","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of our study was to investigate the effect of rectus muscle reapproximation at cesarean delivery (CD) on postoperative pain and rectus muscle diastasis.</div></div><div><h3>Methods</h3><div>Our study was planned as a prospective, randomized study in our clinic between December 2019 and March 2021. The study group included women &gt;37 weeks of gestation, undergoing CD for the first time, with no prior history of pelvic or abdominal surgery, 18–40 years of age. Patients were randomly assigned to either the rectus muscle reapproximation group or the control group. Patients were evaluated at postoperative 1st day and 6th week. The primary outcome was the comparison of the Visual Analogue Scale (VAS) score and inter-rectus diatance (IRD) among the groups. Additionally, factors associated with rectus diastasis were also analyzed using logistic regression.</div></div><div><h3>Results</h3><div>A total of 306 women undergoing primary cesarean sections were randomized, and 296 were included in the final analysis. There was no significant difference in terms of VAS score and postoperative analgesia need among the groups. IRD 2 cm below umbilicus was significantly shorter in rectus muscle reapproximation group at postoperative 6th week. The logistic regression analysis showed that rectus muscle reapproximation had a negative impact on the development of rectus diastasis below umbilicus (OR = 2.830, p = 0.013).</div></div><div><h3>Conclusion</h3><div>Rectus muscle reapproximation during CD resulted in less rectus diastasis below umbilicus. On the other hand it did not affect postoperative VAS score.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113966"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Prevalence and sociodemographic distribution of endometriosis symptoms and indicators in Denmark” [Eur. J. Obstet. Gynecol. Reprod. Biol. 307 (2025) 109–120]","authors":"Marie Josiasen ,&nbsp;Eeva Liisa Røssell ,&nbsp;Tong Zhu ,&nbsp;Anna Melgaard ,&nbsp;Lucky Saraswat ,&nbsp;Andrew W. Horne ,&nbsp;Karina Ejgaard Hansen ,&nbsp;Dorte Rytter","doi":"10.1016/j.ejogrb.2025.113953","DOIUrl":"10.1016/j.ejogrb.2025.113953","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113953"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of ectopic pregnancy from 1990 to 2019: A tendency, forecasted trend and inequality analyses based on the Global Burden of Disease Study 2019","authors":"Wenwen Chen ,&nbsp;Yuanzhi Zhou ,&nbsp;Xu Zhang ,&nbsp;Xinyu Xu ,&nbsp;Yan Yin ,&nbsp;Shuixiang He","doi":"10.1016/j.ejogrb.2025.113957","DOIUrl":"10.1016/j.ejogrb.2025.113957","url":null,"abstract":"<div><h3>Background</h3><div>Ectopic pregnancy (EP) is a dangerous obstetric condition that can occur anywhere throughout the world. This study explored the burden, health inequality analysis, and future trends related to EP to assist in formulating the next steps of public health policies.</div></div><div><h3>Methods</h3><div>The epidemiological characteristics of EP classified by age, year, and socioeconomic level were assessed in global, regional, and national groups based on Global Burden of Disease 2019. This study analyzed incidence, mortality, disability-adjusted life years (DALYs), age-standardized rate (ASR); average annual percentage change (AAPC), and<!--> <!-->estimated annual percentage change (EAPC).<!--> <!-->The article further predicts its change over the next 30 years and quantifies cross-national health inequalities.</div></div><div><h3>Results</h3><div>In 2019, the global number of new cases was 6,692,404.75 (95 % UI = 5,225,400.95–8,598,569.75), a decrease from 7,453,267.43 (95 % UI = 5,738,984.72–9,557,077.85) in 1990; and the age-standardized deaths rate (ASDR) was 0.16 (95 % UI = 0.14–0.19), a slight decrease from 0.22 (95 % UI = 0.19–0.24) in 1990.<!--> <!-->The EAPC for ASDR showed an average annual decrease of −0.91 (95 % CI = -1.04 − -0.78). In addition, ASR DALYs of EP decreased from 12.46 (95 % UI = 11.09–13.91) in 1990 to 9.69 (95 % UI = 8.27–11.31) in 2019. Projections indicate that by 2049, the ASIR will rise to 149.91 (95 % UI = 11.77–288.05) and the ASDR will rise to 0.18 (95 % UI = 0.05–0.31). Concentration indices of EP death and DALYs increased between 1990 and 2019. Health inequalities show that the concentration index for the EP DALY ratio decreased from -0.46 (95 % CI = -0.55 to -0.38) in 1990 to -0.61 (95 % CI = -0.70 to -0.52) in 2019 and the concentration index for EP death decreased from -0.47 (95 %CI = -0.56 to -0.39) in 1990 to -0.62 (95 %CI = -0.71- -0.53) in 2019.</div></div><div><h3>Conclusions</h3><div>This study emphasizes the significant burden of EP, especially for low socio-demographic index countries. Addressing health inequality is crucial for developing effective intervention policies to improve global maternal health outcomes.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113957"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid closed loop insulin therapy versus standard therapy in pregnant women with type 1 diabetes: A systematic review and meta-analysis of randomized controlled trials","authors":"Sohaira Tahir ,&nbsp;Shafia Naeem ,&nbsp;Izzah Nayyab ,&nbsp;Aafia Batool ,&nbsp;Sameer Emeish ,&nbsp;Ilma Hasan ,&nbsp;Arjun Dhir ,&nbsp;Jawad Shahid ,&nbsp;Muhammad Sheraz ,&nbsp;Jaskaran Singh ,&nbsp;Amandeep Kaur ,&nbsp;Mohammad Umer ,&nbsp;Antonio Simone Laganà","doi":"10.1016/j.ejogrb.2025.113969","DOIUrl":"10.1016/j.ejogrb.2025.113969","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to explore the efficacy and safety of hybrid closed loop (HCL) systems compared to standard care (SC) in pregnant women with Type 1 Diabetes Mellitus (T1DM), pooling results from randomized controlled trials (RCTs).</div></div><div><h3>Data sources</h3><div>We searched through multiple databases like PubMed, Cochrane, Embase, Web of Science, and <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> etc. from inception to September 2024 and found six relevant studies after screening.</div></div><div><h3>Study eligibility criteria</h3><div>We included studies that were (1) RCTs; with patient population (2) pregnant patients with type 1 diabetes; intervention group receiving (3) HCL and control group receiving (4) SC; while reporting (5) outcomes of interest (endpoints). We pooled results pertaining to primary outcomes; time in range (TIR), nocturnal time in range (nTIR), and HbA1c; and relevant secondary outcomes.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>We used Rob 2: A revised Cochrane risk-of-bias tool for randomized trials for quality assessment of the included RCTs. We employed the DerSimonian-Laird random effects model using review manager 5.4 to analyze the pooled estimates and reported results as risk ratio; for dichotomous outcomes; or mean difference; for continuous outcomes.</div></div><div><h3>Results</h3><div>Five RCTs (n = 274) with disparate populations were narrowed down for analysis. Pooled estimates for TIR (MD 4.95 %;−0.56 to 10.49)and HbA1c% (MD 0.09; −0.44 to 0.63) were statistically non-significant, while estimates for nTIR (MD 11.16 %; 7.15 to 15.15), % time &lt; 63 mg/dL (MD –0.78; −1.36 to −0.20), % of time &lt; 54 mg/dL (MD –0.22; −0.40 to −0.03), low blood glucose index (LBGI) (MD –0.30; −0.54 to −0.06), and glucose standard deviation (MD −3.05; −6.06 to −0.04) favored HCL over SC. No significant between-group differences were found in other secondary outcomes: % of time &gt;140 mg/dL, % of time &gt;180 mg/dL, mean glucose level, rate of serious adverse events, cesarian delivery, and severe hypoglycemia.</div></div><div><h3>Conclusions</h3><div>HCL systems can improve glycemic control in pregnant women with T1DM with a tolerable adverse event profile, however more research is needed to draw a definitive conclusion.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113969"},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain ratio elastography of the uterine cervix and prediction of successful labor induction","authors":"Maria Strandbo Schmidt Jensen ,&nbsp;Christine Rohr Thomsen ,&nbsp;Mogens Hinge ,&nbsp;Niels Uldbjerg ,&nbsp;Puk Sandager","doi":"10.1016/j.ejogrb.2025.113972","DOIUrl":"10.1016/j.ejogrb.2025.113972","url":null,"abstract":"<div><h3>Background</h3><div>Before labor induction, the uterine cervix is often evaluated by the Bishop score, or a modified Bishop score, to predict the duration and success of induction. However, more objective methods are wanted. Strain ratio elastography is a technique that evaluates the elastic modulus of a tissue. Using strain ratio elastography in combination with a reference material enables quantitative elastography of the uterine cervix.</div></div><div><h3>Objective</h3><div>To evaluate the associations between the apparent elastic modulus of the cervical tissue assessed by strain ratio elastography and the cervical dilation time after labor induction.</div></div><div><h3>Methods</h3><div>Twenty-two nulliparous pregnant women admitted for labor induction were included. A Bishop score, a cervical length measured by ultrasound and an elastic modulus evaluated by strain ratio elastography were obtained from all participants. Primary outcomes were cervical dilation time from labor induction to active labor and from active labor to full cervical dilation.</div></div><div><h3>Results</h3><div>The strain ratio was not associated with the time from labor induction to active labor R²: 0,024 (P = 0.492), but there was a small association between strain ratio and time from active labor to full cervical dilatation R²: 0.180, however not significant (<em>P</em> = 0.063). The cervical length was associated with time from labor induction to active phase R²: 0.134 (<em>P</em> = 0.003), but not with time from active labor to full dilatation R²: 0.015 (<em>P</em> = 0.610).</div></div><div><h3>Conclusions</h3><div>The results indicate a possible importance of the elastic modulus for predicting time from active labor to full cervical dilatation, whereas the cervical length seems to be of greater importance for time from labor induction to active labor.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 113972"},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}