European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"First-trimester fetal reduction using microwave ablation in high-order pregnancies with a monochorionic component: Feasibility and outcomes.","authors":"Selcan Sinaci, Fatma Didem Yucel Yetiskin, Hatice Eylem Komurculer, Aslihan Kurt, Ilgın Turkcuoglu","doi":"10.1016/j.ejogrb.2026.115167","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115167","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the feasibility and short-term outcomes of first-trimester ultrasound-guided microwave ablation (MWA) for selective fetal reduction in high-order multiple pregnancies containing a monochorionic component.</p><p><strong>Methods: </strong>This retrospective single-center case series included all triplet and higher-order pregnancies with a monochorionic component undergoing first-trimester MWA between October 2023 and February 2026. Primary outcomes were technical success and pregnancy-level complications. Secondary outcomes included gestational age at delivery and neonatal outcomes.</p><p><strong>Results: </strong>Fifteen pregnancies (8 triplet, 5 quadruplet, 2 quintuplet) comprising 23 targeted fetuses were included. Mean gestational age at intervention was 13 + 1 weeks, with procedures performed between 11 + 3 and 14 + 4 weeks of gestation. Technical success was achieved in all targeted fetuses (23/23, 100%). One unintended intraprocedural demise of a non-target monochorionic co-fetus occurred (1/15 pregnancies, 6.7%). Among 13 completed pregnancies, 11 delivered as twins, one as triplets, and one as a singleton. Mean gestational age at delivery was 36 + 4 weeks, with deliveries occurring between 33 + 0 and 38 + 2 weeks. Twenty-six neonates were delivered, all live-born. No neonatal deaths were observed.</p><p><strong>Conclusion: </strong>In high-order pregnancies containing a monochorionic component, targeted elimination of the monochorionic compartment using MWA was technically feasible and resulted predominantly in dichorionic twin gestations, with short-term outcomes that appear acceptable within the context of high-order pregnancies, although no direct comparison with other reduction techniques was performed. Larger studies with longer follow-up are warranted.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115167"},"PeriodicalIF":1.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic pain and generalized persistent pain in people with mayer-rokitansky-küster-hauser syndrome: a cross-sectional survey study.","authors":"Riya Gaikaiwari, Sonia R Grover, Ian Wright, Andrew R Battle, Natalie Drever","doi":"10.1016/j.ejogrb.2026.115159","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115159","url":null,"abstract":"<p><strong>Background: </strong>Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterised by congenital underdevelopment of the uterus and vagina. While absence of menstruation might be expected to reduce pelvic pain, the prevalence and nature of pain syndromes in MRKH are not well established.</p><p><strong>Aims: </strong>To determine the prevalence and severity of self-reported chronic pelvic pain (CPP) and generalised persistent pain (GPP) in a large Australian sample of women with MRKH, and to compare findings with general population estimates.</p><p><strong>Materials and methods: </strong>A cross-sectional online survey was conducted in collaboration with MRKH Australia. Validated questionnaires were used to assess CPP and GPP, somatic symptom burden, and depressive symptoms. Data on age, self-reported uterine remnant status, and prior diagnosis of fibromyalgia were also collected.</p><p><strong>Results: </strong>Among 142 participants (median age 32, range 18-71), 34.0% reported no pelvic pain in the preceding three months, while 38.3% reported moderate to severe CPP. Overall, 3.5% reported a diagnosis of fibromyalgia, comparable to global female prevalence, and 55.2% reported depressive symptoms. Younger participants described a higher burden of somatic symptoms. Pelvic pain was strongly associated with increased likelihood of GPP.</p><p><strong>Conclusions: </strong>Women with MRKH experience moderate to severe CPP and GPP symptoms at rates comparable to those reported in the general female population. This study was designed to estimate the prevalence and severity of pelvic and generalised persistent pain, rather than to determine specific pain aetiologies. Early recognition of pain symptoms and integration of holistic, patient-centred care addressing both somatic and psychosocial contributors are recommended.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115159"},"PeriodicalIF":1.9,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prior caesarean delivery on perioperative outcomes of vNOTES hysterectomy: a propensity-score-matched study.","authors":"Candost Hanedan, Oğuz Kaan Köksal, Şahin Kaan Baydemir, Neslihan Öztürk, Hande Nur Öncü, Gökçen Ege, Aysu Yeşim Tezcan, Tuba Zengin Aksel, Fulya Kayıkcıoğlu, Çağanay Soysal, Vakkas Korkmaz","doi":"10.1016/j.ejogrb.2026.115150","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115150","url":null,"abstract":"<p><strong>Study objective: </strong>Vaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy has emerged as a minimally invasive alternative to conventional laparoscopic and vaginal hysterectomy. However, a history of caesarean delivery is often considered a technical challenge due to adhesions and the potential risk of bladder injury. This study aimed to evaluate the impact of prior caesarean delivery on perioperative outcomes of vNOTES hysterectomy for non-malignant gynaecological indications.</p><p><strong>Study design: </strong>This single-centre retrospective study included patients who underwent vNOTES hysterectomy ± bilateral salpingo-oophorectomy at Etlik City Hospital, one of the largest tertiary referral hospitals in Turkey, between September 2023 and January 2026. All procedures were performed by two experienced surgeons, both of whom had performed more than 50 VNOTES procedures prior to the study period and were certified in vNOTES hysterectomy. Patients were grouped according to prior caesarean delivery status. Propensity score matching was performed in a 1:1 ratio, resulting in 49 patients per group. Perioperative outcome, complication and 30-day re-admission rates were compared, and subgroup analysis was conducted according to the number of prior caesarean deliveries.</p><p><strong>Results: </strong>After matching, baseline characteristics were well balanced. The operative time and reduction in haemoglobin were similar between the groups (p = 0.082 and p = 0.232, respectively). Intraoperative complication rates were 4.1% (2/49) and 10.2% (5/49) in the no prior caesarean and prior caesarean groups, respectively (p = 0.436), and postoperative complication rates were 8.2% (4/49) and 10.2% (5/49), respectively (p = 1.000), with no significant differences between the groups. Conversion to laparoscopy occurred only in women with a history of caesarean delivery (3/49 patients, 6.1%), but the difference was not significant. In subgroup analysis, women with a history of two or more caesarean deliveries had a longer operative time (p < 0.001), with no differences in the reduction in haemoglobin, complication rate, conversion rate or readmission rate.</p><p><strong>Conclusion: </strong>While significant differences were not reached, the conversion rate and perioperative complication rate were higher in patients with a history of caesarean delivery, suggesting that a history of caesarean delivery may be associated with increased perioperative morbidity. Although operative time may be prolonged in patients with a history of multiple caesarean deliveries, major morbidity and re-admission rates remain comparable. Overall, a history of caesarean delivery may not compromise the feasibility of vNOTES hysterectomy, and these patients may still be considered as suitable candidates when the procedure is performed by surgeons experienced in vNOTES hysterectomy.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115150"},"PeriodicalIF":1.9,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern to \"Bladder function after sacrospinous hysteropexy and vaginal wall repair in women with uterovaginal prolapse\" [Eur. J. Obstet. Gynecol. Reprod. Biol. 224 (2018) 170-174].","authors":"Waleed A Sayed Ahmed, Omima T Taha, Mostafa A Hamdy, Zakia M Ibrahim, Amal M Elshahat","doi":"10.1016/j.ejogrb.2026.115029","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115029","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"321 ","pages":"115029"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal corticosteroids for short cervix: When is it indicated - a cohort study.","authors":"Lennart Van der Veeken, Diya Ahmad, Simonne Holubeshen, Kellie E Murphy, John W Snelgrove","doi":"10.1016/j.ejogrb.2026.115156","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2026.115156","url":null,"abstract":"<p><strong>Introduction: </strong>Antenatal corticosteroids (ACS) improve outcomes for children born before 34 weeks, with timing being crucial. Administration within seven days before birth is optimal. After longer intervals the benefits are less clear and ACS might even be harmful if delivery occurs at term. We aimed to assess the rate of optimally timed ACS across different indications and explore strategies to improve timing.</p><p><strong>Material and methods: </strong>We conducted a 10-year retrospective cohort study of all pregnant patients receiving ACS at a single center from 2014 to 2023. Patients lost to follow-up < 14 days were excluded. Clinical characteristics and birth outcomes were collected. ACS timing was categorized by interval to birth: <2 days (late), 2-7 days (optimal), 7-14 days (suboptimal), and > 14 days (early). Timing accuracy was evaluated per indication. Four alternative administration strategies were modeled to assess potential improvements.</p><p><strong>Results: </strong>Among 4578 patients, the most common indications were threatened preterm birth (24%), PPROM (19%), and short cervix (16%). Overall, 33% received ACS within 7 days of delivery and 44% within 14 days, with no improvement over the decade. In patients with a short cervix (23% of the cohort), ACS timing was late in 1%, optimal in 9%, suboptimal in 7%, and early in 84%. Restricting ACS to those with an open cervix would result in 50% receiving ACS within 14 days of birth. For patients with a short but closed cervix, administering ACS only when symptoms developed would result in late or missed ACS in 4%. Withholding ACS in asymptomatic patients could avoid or delay treatment in 76% while increasing optimal/suboptimal timing to 45%.</p><p><strong>Conclusion: </strong>ACS for asymptomatic short cervix is rarely optimally timed. Targeted administration based on cervical status and symptoms may substantially improve timing accuracy.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"323 ","pages":"115156"},"PeriodicalIF":1.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of preoperative serum CA-125 and fibrinogen levels in predicting lymph node metastasis, myometrial invasion, and lymphovascular space invasion in patients with endometrial cancer","authors":"Neçirvan Çağdaş Çaltek ,&nbsp;Mahmut Yassa ,&nbsp;Gözde Şahin ,&nbsp;Yahya Özgün Öner ,&nbsp;İlteriş Yaman ,&nbsp;Can Berk Karabudak ,&nbsp;İlkbal Temel Yüksel","doi":"10.1016/j.ejogrb.2026.114985","DOIUrl":"10.1016/j.ejogrb.2026.114985","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate whether preoperative serum levels of cancer antigen 125 (CA-125) and fibrinogen could provide clinical guidance for surgical planning and treatment management in patients with endometrial cancer.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective study was conducted, including 582 patients who underwent surgery for endometrial cancer between October 2020 and December 2024 at a tertiary centre. Preoperative CA-125 and fibrinogen levels, clinical variables, and postoperative pathological findings were collected from electronic medical records. The primary outcome was lymph node metastasis (LNM). The secondary outcomes were myometrial invasion (MI) ≥ 50% and the presence of lymphovascular space invasion (LVSI). Independent predictors of LNM, MI ≥ 50% and LVSI were evaluated using multivariable logistic regression based on TRIPOD-aligned preoperative and postoperative modelling frameworks. Model performance was assessed through area under the receiver operating characteristic curve (ROC–AUC), calibration metrics, and decision curve analysis. Optimal biomarker thresholds were determined using ROC analysis and the Youden index. Sensitivity analyses examined the diagnostic performance of the Mayo low-risk criteria and the additional value of incorporating CA-125 ≥ 29.1 U/ml.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;MI ≥ 50%, LVSI and LNM were identified in 37.3%, 33.2% and 13.2% of patients, respectively. An elevated CA-125 level was significantly associated with MI ≥ 50%, LVSI and LNM (all &lt;em&gt;P&lt;/em&gt; &lt; 0.001), while the fibrinogen level only differed between LNM groups (&lt;em&gt;P&lt;/em&gt; = 0.009). In univariable analyses, multiple clinicopathological factors – including age, body mass index (BMI), tumour grade, histological subtype, cervical stromal involvement, lower uterine segment involvement, tumour size, MI ≥ 50%, LVSI, CA-125 and fibrinogen – were associated with LNM. In the preoperative model (Model 1), CA-125 [odds ratio (OR) 1.02; &lt;em&gt;P&lt;/em&gt; &lt; 0.001], older age (OR 1.05; &lt;em&gt;P&lt;/em&gt; = 0.001) and lower BMI (OR 0.92; &lt;em&gt;P&lt;/em&gt; = 0.001) were independent predictors of LNM, yielding an AUC of 0.805. In the postoperative model (Model 2), LVSI was the strongest predictor (OR 20.46; &lt;em&gt;P&lt;/em&gt; &lt; 0.001), and the model demonstrated improved predictive performance (AUC 0.889). CA-125 remained independently associated with LNM in both models. CA-125 alone achieved an AUC of 0.740 with an optimal cut-off of 29.1 U/ml. For the secondary outcomes, age, tumour size, grade and LVSI independently predicted MI ≥ 50% (AUC 0.862), whereas BMI, histological subtype, cervical stromal involvement, MI ≥ 50% and tumour size independently predicted LVSI (AUC 0.886). Fibrinogen did not have independent predictive value for MI or LVSI. In a sensitivity analysis, the addition of CA-125 ≥ 29.1 U/ml to the Mayo low-risk criteria improved the detection of LNM in cases initially classified as low risk.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"320 ","pages":"Article 114985"},"PeriodicalIF":1.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for persistent urinary incontinence after sling surgery in patients with urethral funneling","authors":"Enrique González-Díaz,&nbsp;Leticia Padilla Mozo,&nbsp;Ester Fraile López,&nbsp;Camino Fernández Fernández","doi":"10.1016/j.ejogrb.2026.115000","DOIUrl":"10.1016/j.ejogrb.2026.115000","url":null,"abstract":"<div><h3>Objective</h3><div>To identify preoperative prognostic factors associated with persistent urinary incontinence (UI) following mid-urethral sling (MUS) surgery in women with sonographically confirmed urethral funneling.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Tertiary referral center with a specialized urogynecology unit.</div></div><div><h3>Patients</h3><div>Forty-seven women diagnosed with stress UI or stress-predominant mixed UI and urethral funneling on preoperative pelvic floor ultrasound (PFUS), undergoing MUS surgery.</div></div><div><h3>Interventions</h3><div>MUS surgery performed retropubic (TVT) or transobturator (TOT) approach.</div></div><div><h3>Measurements and main results</h3><div>Preoperative evaluation included clinical assessment, voiding diary, validated symptom questionnaires (ICIQ-UI-SF), and PFUS. Surgical success was defined as complete resolution of incontinence 24 months postoperatively. Persistent UI was observed in 27.7% of patients. On univariate analysis, higher ICIQ-UI-SF scores (p = 0.0023), longer urethral length (p = 0.011), and TOT use (p = 0.0065) were significantly associated with persistent UI. ROC curves identified ICIQ-UI-SF ≥ 18 (AUC = 0.731) and urethral length ≥ 35 mm (AUC = 0.654) as optimal cutoffs. In multivariate analysis, both ICIQ-UI-SF ≥ 18 (OR = 6.2, 95% CI: 1.2–31, p = 0.028) and TOT (OR = 6.8, 95% CI: 1.6–28.5, p = 0.009) remained independent predictors. The model showed good discrimination (AUC = 0.84).</div></div><div><h3>Conclusion</h3><div>Among women with urethral funneling, greater symptom severity and the use of TOT are independently associated with persistent UI after MUS. The retropubic approach (TVT) may yield better outcomes in this high-risk population. Incorporating these predictors into preoperative decision-making may enhance surgical planning and patient counseling.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"320 ","pages":"Article 115000"},"PeriodicalIF":1.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to stop? A single center experience on vacuum-assisted deliveries","authors":"Elad Preuss ,&nbsp;Atara De Porto ,&nbsp;Vadim Sheiman ,&nbsp;Moran Bitton ,&nbsp;Josef Tovbin ,&nbsp;Hagit Itzhak Kedem ,&nbsp;Eran Barzilay","doi":"10.1016/j.ejogrb.2026.114983","DOIUrl":"10.1016/j.ejogrb.2026.114983","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between vacuum-assisted vaginal delivery (VAVD) duration and procedural failure and neonatal morbidity, including major neonatal birth trauma, and to assess independent predictors of failed VAVD.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of singleton, vertex pregnancies undergoing a trial of VAVD at a single center. VAVD duration was defined as time from first traction to delivery (successful VAVD) or to the decision to abandon the attempt (failed VAVD). Neonatal morbidity included Apgar scores and arterial pH, and major birth trauma outcomes were extracted from neonatal records. Multivariable logistic regression was performed to identify independent predictors of failed VAVD.</div></div><div><h3>Results</h3><div>Among 2,355 VAVD attempts, 39 (1.7%) failed and all were delivered by cesarean. Failed VAVD had substantially higher cup detachment rates (61.5% vs 9%, p &lt; 0.001) and longer duration (median 12 vs 4 min, p &lt; 0.001). Neonatal outcomes were worse in failed VAVD, including higher rates of low 1-minute Apgar, low 5-minute Apgar, low arterial pH, and composite neonatal morbidity. Major birth trauma extraction identified higher subgaleal hematoma rates in failed VAVD, while intracranial bleeding was not documented. In time-dependent analyses, success declined from 98.3% at commencement to 61.5% at 20 min, whereas composite neonatal morbidity increased from 12.2% to 57.7%. In multivariable analysis, cup detachment, induction of labor, lower head station, and longer duration independently predicted failure.</div></div><div><h3>Conclusion</h3><div>Prolonged VAVD is associated with lower success and higher neonatal morbidity. Duration should inform dynamic reassessment alongside event-based stopping criteria, particularly cup detachments.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"320 ","pages":"Article 114983"},"PeriodicalIF":1.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating quality of life instruments into clinical care for benign gynecological conditions to enhance patient-centered care","authors":"Brooke Neumann ,&nbsp;Morgan Bou Zerdan ,&nbsp;Thammatat Vorawandthanachai ,&nbsp;Elizabeth Schlant ,&nbsp;Ibelle Madera ,&nbsp;Bhuchitra Singh","doi":"10.1016/j.ejogrb.2026.114998","DOIUrl":"10.1016/j.ejogrb.2026.114998","url":null,"abstract":"<div><div>The quality-of-life (QoL) impacts of benign gynecological conditions, such as polycystic ovarian syndrome (PCOS), endometriosis, and uterine fibroids on patients’ lives are underestimated. Upon analysis of the 36-Item Short Form Health Survey questionnaire (SF-36), which assesses physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health, benign gynecological conditions reveal comparable or worse QoL scores compared to QoL scores in other chronic conditions such as diabetes mellitus, breast cancer, and heart disease. The current medical care models focus majorly on physical symptoms and can sometimes fail to capture the full impact of these diseases on patients’ livelihood and well-being. The objective of this perspective paper was to analyze the utility of QoL-related PROMs in obtaining a holistic understanding of the impact of benign gynecological conditions on patients’ lives. QoL-related patient-reported outcome measures (PROMs) can be integrated into clinical practice with the goal of delivering comprehensive, patient-centered care for these diseases. The inclusion of QoL-related PROMs can help characterize a patient’s physical baseline, track improvement or worsening of symptoms throughout the diagnostic and therapeutic course (pre and post intervention. The inclusion of PROMs in patient care settings can facilitate efficient communication between patients and providers for a clinical interaction that is more holistic and patient centered.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"320 ","pages":"Article 114998"},"PeriodicalIF":1.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letrozole-stimulated vs artificial hormone-replacement cycles for frozen-thawed embryo transfer in polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Carolina Alves Felippe ,&nbsp;Sinrraim dos Santos Chaves ,&nbsp;Deivyd Vieira Silva Cavalcante ,&nbsp;Giovana de Souza Gaio ,&nbsp;Rebeca Ferreira de Souza ,&nbsp;Helen Michaela de Oliveira","doi":"10.1016/j.ejogrb.2026.114999","DOIUrl":"10.1016/j.ejogrb.2026.114999","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"320 ","pages":"Article 114999"},"PeriodicalIF":1.9,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}