European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Expression of Concern: Tinelli A, Malvasi A, Istre O, Keckstein J, Stark M, Mettler L. Abdominal access in gynaecological laparoscopy: a comparison between direct optical and blind closed access by Verres needle. Eur J Obstet Gynecol Reprod Biol. 2010;148(2):191-4. doi: 10.1016/j.ejogrb.2009.10.025.","authors":"","doi":"10.1016/j.ejogrb.2025.114708","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.114708","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"314 ","pages":"114708"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing matters: Surgery-to-chemotherapy interval and outcomes in ovarian cancer.","authors":"Y Siegler, A Omer, Y Yousef, C Ben David, N Justman, R Linder, A Amit, E Matanes","doi":"10.1016/j.ejogrb.2025.114772","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.114772","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association of the time interval between cytoreductive surgery and the initiation of adjuvant chemotherapy on treatment success in epithelial ovarian cancer.</p><p><strong>Methods: </strong>A retrospective single center cohort study of patients diagnosed with high grade epithelial ovarian cancer between 2011 and 2023. Patients received either primary cytoreductive surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval cytoreductive and additional chemotherapy. Chemotherapy regimens were platinum based and included carboplatin and paclitaxel; Bevacizumab or Olaparib were added per guidelines. Time to chemotherapy (TTC) was categorized into ≤28, ≤35, and ≤42 days. Primary outcomes were overall survival (OS) and progression-free survival (PFS), analyzed using hazard ratios and 95 % confidence intervals.</p><p><strong>Results: </strong>The study included 197 women with high grade epithelial ovarian carcinoma. Median OS and PFS were 29.5 and 15.1 months, respectively. Average TTC was 46.1 days with a median of 36 days. Time to chemotherapy interval less than 28 days showed a statistically insignificant trend for improved OS compared to TTC higher than 28 days with HR 1.54 (0.98-2.42) and p = 0.06. A subgroup analysis of women within this group demonstrated a significantly improved OS in patients diagnosed with stage IIIA to IVB and patients that underwent interval cytoreductive procedure (HR 1.80 [1.13-2.87], p = 0.004, HR 2.5 [1.41-4.43] p = 0.002, respectively).</p><p><strong>Conclusions: </strong>Initiating chemotherapy within 28 days following cytoreductive surgery, may contribute to improved overall survival in ovarian cancer, particularly in patients with advanced-stage disease and patients underwent interval cytoreductive surgery.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"114772"},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal outcomes in patients with preeclampsia and elevated sFlt-1/PlGF before term. A retrospective cohort study.","authors":"Saskya Linares, Osvaldo Reyes","doi":"10.1016/j.ejogrb.2025.114770","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.114770","url":null,"abstract":"<p><strong>Objective: </strong>To determine the usefulness of different thresholds of the sFlt-1/PlGF ratio in predicting maternal and perinatal complications in preterm pregnancies with suspected preeclampsia.</p><p><strong>Material and methods: </strong>This was a retrospective cohort study that analyzed 188 preterm preeclampsia patients with a sFlt-1/PlGF ratio >110 based on last value before delivery: 110-205 (controls), ≥206, ≥655, ≥1000 (cases). Perinatal outcomes were compared between controls and cases.</p><p><strong>Results: </strong>An sFlt-1/PlGF ratio ≥206 was associated with higher risk of intrauterine growth restriction (14.3 % vs 36.4 %, p = 0.003), severe preeclampsia (66.1 % vs 84.8 %, p = 0.003), thrombocytopenia (3.6 % vs 15.2 %, p = 0.03), 5-minute Apgar ≤6 (0 % vs 10.6 %, p = 0.01) and lower gestational age at birth (33.7 vs 30.9 weeks, p < 0.00001). An sFlt-1/PlGF ratio ≥655 was associated with all the above plus proteinuria (1.3 vs 4.5 g/24 h, p = 0.0001), HELLP (1.8 % vs 17.3 %, p = 0.005) and 1-minute Apgar ≤6 (10.7 % vs 26.9 %, p = 0.03). An sFlt-1/PlGF ratio ≥1000 was associated with all the above plus liver enzyme abnormalities (8.9 % vs 25.6 %, p = 0.03) and stillbirths (0 % vs 10.3 %, p = 0.02).</p><p><strong>Conclusion: </strong>In cases of preterm preeclampsia, an elevated sFlt-1/PlGF ratio is linked to increased maternal and perinatal complications. Ratios of ≥206 signal this heightened risk, while those of ≥1000 are additionally associated with a greater risk of stillbirth. These ratios could help in making better clinical decisions, regarding timing of delivery, weighing the risks of gestational age against the potential adverse events suggested by their values.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"114770"},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent vNOTES risk reducing bilateral salpingo-oophorectomy at the time of mastectomy in women with breast cancer and BReast CAncer (BRCA) gene mutation","authors":"Wai Yoong ,&nbsp;Sarah Wylie ,&nbsp;Jasdeep Gahir ,&nbsp;Joachim Ho","doi":"10.1016/j.ejogrb.2025.114761","DOIUrl":"10.1016/j.ejogrb.2025.114761","url":null,"abstract":"<div><h3>Objective</h3><div>Women with breast cancer and BRCA gene mutation should be offered bilateral risk reducing salpingo-oophorectomy (RRBSO) due to lifetime ovarian cancer risk. Laparoscopic BSO, either concurrently or following index mastectomy, is benchmark but vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) gaining traction as an alternative route. We report three novel cases of simultaneous “dual site” surgery in women with breast cancer and BRCA inheritance.</div></div><div><h3>Methods</h3><div>vNOTES RRBSO is performed prior to breast surgery during the “dual site” procedure. As recommended by National Comprehensive Cancer Network, salpingectomy was completed to the level of cornu and ovarian pedicle was excised distally to include 2 cm margin. Peritoneal cytology was obtained and bowel, omentum, appendix and pelvic organs were inspected. Data collected included age, BMI, Ca-125 levels, duration of surgery, estimated blood loss, length of stay, 24 hour VAS, peri-operative complications, sexual function (FSFI-6), and recovery status (RI-10).</div></div><div><h3>Results</h3><div>Three women underwent concomitant vNOTES RRBSO and mastectomy. Median operative time and postoperative stay were 45 mins and 26 hours and there were no complications. Sexual function appeared unaffected by the vNOTES approach (FSFI-6 median score 6 <em>vs</em> 4) and normal activity resumed within 23 days. Histology of fallopian tubes and ovaries was benign.</div></div><div><h3>Conclusion</h3><div>Concomitant vNOTES RRBSO and mastectomy avoids a second surgical admission and repeat anaesthesia and does not appear to delay recovery. Findings support adoption of vNOTES as a patient-friendly alternative which can be performed concurrently with mastectomy.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114761"},"PeriodicalIF":1.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent vNOTES risk reducing bilateral salpingo-oophorectomy at the time of mastectomy in women with breast cancer and BReast CAncer (BRCA) gene mutation","authors":"Wai Yoong ,&nbsp;Sarah Wylie ,&nbsp;Jasdeep Gahir ,&nbsp;Joachim Ho","doi":"10.1016/j.ejogrb.2025.114761","DOIUrl":"10.1016/j.ejogrb.2025.114761","url":null,"abstract":"<div><h3>Objective</h3><div>Women with breast cancer and BRCA gene mutation should be offered bilateral risk reducing salpingo-oophorectomy (RRBSO) due to lifetime ovarian cancer risk. Laparoscopic BSO, either concurrently or following index mastectomy, is benchmark but vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) gaining traction as an alternative route. We report three novel cases of simultaneous “dual site” surgery in women with breast cancer and BRCA inheritance.</div></div><div><h3>Methods</h3><div>vNOTES RRBSO is performed prior to breast surgery during the “dual site” procedure. As recommended by National Comprehensive Cancer Network, salpingectomy was completed to the level of cornu and ovarian pedicle was excised distally to include 2 cm margin. Peritoneal cytology was obtained and bowel, omentum, appendix and pelvic organs were inspected. Data collected included age, BMI, Ca-125 levels, duration of surgery, estimated blood loss, length of stay, 24 hour VAS, peri-operative complications, sexual function (FSFI-6), and recovery status (RI-10).</div></div><div><h3>Results</h3><div>Three women underwent concomitant vNOTES RRBSO and mastectomy. Median operative time and postoperative stay were 45 mins and 26 hours and there were no complications. Sexual function appeared unaffected by the vNOTES approach (FSFI-6 median score 6 <em>vs</em> 4) and normal activity resumed within 23 days. Histology of fallopian tubes and ovaries was benign.</div></div><div><h3>Conclusion</h3><div>Concomitant vNOTES RRBSO and mastectomy avoids a second surgical admission and repeat anaesthesia and does not appear to delay recovery. Findings support adoption of vNOTES as a patient-friendly alternative which can be performed concurrently with mastectomy.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114761"},"PeriodicalIF":1.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel genetic variants of sperm chromatin compaction regulators are associated with non-obstructive azoospermia in Indian men","authors":"Saurav Dutta ,&nbsp;Pranab Paladhi ,&nbsp;Samudra Pal ,&nbsp;Papiya Ghosh ,&nbsp;Ratna Chattopadhyay ,&nbsp;Sujay Ghosh","doi":"10.1016/j.ejogrb.2025.114762","DOIUrl":"10.1016/j.ejogrb.2025.114762","url":null,"abstract":"<div><h3>Background</h3><div>The genetic basis of idiopathic male infertility remains largely elusive and multifactorial. Sperm cells undergo distinct chromatin compaction during spermiogenesis, primarily driven by sperm-specific nuclear proteins—protamines (PRMs) and transition proteins (TNPs). Genetic variations in protamine clusters due to polymorphisms may contribute to male infertility. However, their impact on sperm DNA integrity and fertility outcomes across ethnic groups remains inconsistent and unclear. However, these gene variants have not been studied among the Indian men in the context of male infertility.</div></div><div><h3>Methods</h3><div>This case-control study include collection of blood samples from non-obstructive azoospermic men from Bengali speaking population of West Bengal, India followed by genotyping with Sanger’s sequencing of <em>PRM1</em>, <em>PRM2</em>, <em>TNP1</em> and <em>TNP2</em> genes among 445 non-obstructive azoospermic individuals (negative for Y-chromosome microdeletions) and 375 fertile controls. Suitable statistical methods were used to examine variant association. Additionally, in silico analyses were employed to predict the potential deleterious effects of the identified variants.</div></div><div><h3>Results</h3><div>A total of 15 variants were identified, of which 10 showed significant association with azoospermia among the cases. In silico analyses predicted five variants to be potentially deleterious to the gene’s function or disease-causing: rs75245770C&gt;A and the novel variant OQ266297C&gt;A in <em>PRM1</em>; the novel variants OQ507618A&gt;T and OQ557494G&gt;T in <em>PRM2</em>; and rs11640138C&gt;T in <em>TNP2</em>.</div></div><div><h3>Conclusion</h3><div>Variants in protamine gene cluster may contribute to an increased risk of azoospermia among men in Bengali population. The novel variants identified in this study hold potential as genetic markers for male infertility screening in routine assisted reproductive techniques (ART) practice.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114762"},"PeriodicalIF":1.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel genetic variants of sperm chromatin compaction regulators are associated with non-obstructive azoospermia in Indian men","authors":"Saurav Dutta ,&nbsp;Pranab Paladhi ,&nbsp;Samudra Pal ,&nbsp;Papiya Ghosh ,&nbsp;Ratna Chattopadhyay ,&nbsp;Sujay Ghosh","doi":"10.1016/j.ejogrb.2025.114762","DOIUrl":"10.1016/j.ejogrb.2025.114762","url":null,"abstract":"<div><h3>Background</h3><div>The genetic basis of idiopathic male infertility remains largely elusive and multifactorial. Sperm cells undergo distinct chromatin compaction during spermiogenesis, primarily driven by sperm-specific nuclear proteins—protamines (PRMs) and transition proteins (TNPs). Genetic variations in protamine clusters due to polymorphisms may contribute to male infertility. However, their impact on sperm DNA integrity and fertility outcomes across ethnic groups remains inconsistent and unclear. However, these gene variants have not been studied among the Indian men in the context of male infertility.</div></div><div><h3>Methods</h3><div>This case-control study include collection of blood samples from non-obstructive azoospermic men from Bengali speaking population of West Bengal, India followed by genotyping with Sanger’s sequencing of <em>PRM1</em>, <em>PRM2</em>, <em>TNP1</em> and <em>TNP2</em> genes among 445 non-obstructive azoospermic individuals (negative for Y-chromosome microdeletions) and 375 fertile controls. Suitable statistical methods were used to examine variant association. Additionally, in silico analyses were employed to predict the potential deleterious effects of the identified variants.</div></div><div><h3>Results</h3><div>A total of 15 variants were identified, of which 10 showed significant association with azoospermia among the cases. In silico analyses predicted five variants to be potentially deleterious to the gene’s function or disease-causing: rs75245770C&gt;A and the novel variant OQ266297C&gt;A in <em>PRM1</em>; the novel variants OQ507618A&gt;T and OQ557494G&gt;T in <em>PRM2</em>; and rs11640138C&gt;T in <em>TNP2</em>.</div></div><div><h3>Conclusion</h3><div>Variants in protamine gene cluster may contribute to an increased risk of azoospermia among men in Bengali population. The novel variants identified in this study hold potential as genetic markers for male infertility screening in routine assisted reproductive techniques (ART) practice.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114762"},"PeriodicalIF":1.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 5-year results of an institutional shadowing program aiming to train new senior \"obstetricians on-call\".","authors":"Daniel Tairy, Eran Weiner, Anat Engel, Adar Paz, Yael Ganor Paz","doi":"10.1016/j.ejogrb.2025.114760","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.114760","url":null,"abstract":"<p><strong>Background: </strong>On-call night and weekend shifts are pivotal components of the clinical activity of any obstetric unit. Worldwide, these teams are usually led by a senior in-house attending obstetrician.</p><p><strong>Objectives: </strong>This study presents the effects of a structured institutional shadowing program in which obstetricians shadow senior residents, with the aim of enhancing the residents' competencies and evaluating obstetric adverse outcomes.</p><p><strong>Study design: </strong>In August 2022, we implemented a training program where senior residents improve complex obstetric and leadership competencies by performing repeated 24-hour calls shadowed by an experienced attending obstetrician. After each 24-hour call, the senior resident received structured oral and written feedback scoring their competencies. Additionally, the senior residents self-assessed their respective competencies upon entering and completing the program using structured questionnaires. Lastly, we compared the occurrence of major maternal and neonatal adverse outcomes before (January 2019 to July 2022 = P1) vs. after (August 2022 to July 2024 = P2) the program implementation.</p><p><strong>Results: </strong>As of August 2024, we performed 151 shadowed 24-hour shifts, conducted by 8 senior residents trained by 15 attending obstetricians. The senior residents' skills were evaluated with a higher performance degree when compared between program entry and completion, as assessed by the attending obstetricians (p < 0.05 for all comparisons). Additionally, when comparing the 13,336 on-call deliveries in P1 to the 8,718 on-call deliveries in P2, the latter period was characterized by lower rates of maternal bleeding and transfusion (p < 0.001), shoulder dystocia (p = 0.04), neonatal Apgar score < 7 (p = 0.009), respiratory morbidity (p = 0.02), Erb's palsy (p = 0.03), and neonatal death (p = 0.05).</p><p><strong>Conclusions: </strong>structured, real-time on call training for senior obstetrics residents can meaningfully enhance clinical competency, leadership skills, and preparedness for independent on-call responsibilities as well as better patient outcomes.</p>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"114760"},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich plasma therapy enhances endometrial receptivity in thin endometrium patients undergoing frozen embryo transfer cycles: results from a prospective cohort observational study","authors":"Kanad Dev Nayar,&nbsp;Shweta Arora,&nbsp;Sabina Sanan,&nbsp;Manika Sachdeva,&nbsp;Ankita Sethi,&nbsp;Gaurav Kant,&nbsp;Kapil Nayar","doi":"10.1016/j.ejogrb.2025.114758","DOIUrl":"10.1016/j.ejogrb.2025.114758","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of intrauterine instillation of autologous platelet-rich plasma (PRP) on women with thin endometrium undergoing frozen embryo transfer.</div></div><div><h3>Methods</h3><div>A prospective cohort observational study was carried out at Akanksha IVF Centre, New Delhi, from 1st August 2023 to 31st July 2024. The study included 100 patients under 40 years with thin endometrium (&lt;7 mm on transvaginal sonography). Participants received hormone replacement therapy (sequential incremental dosage of estradiol valerate) from day 2 of the menstrual cycle. Among them, 70 patients received intrauterine PRP instillation on days 7, 9, and 11 of the cycle, while the remaining 30 patients did not undergo this treatment. Endometrial thickness was monitored, and progesterone was initiated on day 14 or once endometrial thickness surpassed 7 mm, followed by blastocyst transfer on day 6 of progesterone. Pregnancy outcomes were assessed using urine pregnancy tests or serum beta human chorionic gonadotropin levels followed by ultrasound to confirm fetal viability. The main outcomes assessed were improvement in endometrial thickness and clinical pregnancy rate.</div></div><div><h3>Results</h3><div>The administration of PRP through intrauterine instillation significantly increased mean endometrial thickness in the PRP group compared to the non-PRP group (p = 0.032). The clinical pregnancy rate was 35.71 % in the PRP group versus 10 % in the non-PRP group (p = 0.0251). No adverse reactions were observed.</div></div><div><h3>Conclusions</h3><div>PRP therapy significantly enhances endometrial receptivity and improves pregnancy outcomes in patients with refractory thin endometrium. It offers a promising adjunctive treatment for patients facing repeated cycle cancellations in frozen embryo transfer.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114758"},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich plasma therapy enhances endometrial receptivity in thin endometrium patients undergoing frozen embryo transfer cycles: results from a prospective cohort observational study","authors":"Kanad Dev Nayar,&nbsp;Shweta Arora,&nbsp;Sabina Sanan,&nbsp;Manika Sachdeva,&nbsp;Ankita Sethi,&nbsp;Gaurav Kant,&nbsp;Kapil Nayar","doi":"10.1016/j.ejogrb.2025.114758","DOIUrl":"10.1016/j.ejogrb.2025.114758","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of intrauterine instillation of autologous platelet-rich plasma (PRP) on women with thin endometrium undergoing frozen embryo transfer.</div></div><div><h3>Methods</h3><div>A prospective cohort observational study was carried out at Akanksha IVF Centre, New Delhi, from 1st August 2023 to 31st July 2024. The study included 100 patients under 40 years with thin endometrium (&lt;7 mm on transvaginal sonography). Participants received hormone replacement therapy (sequential incremental dosage of estradiol valerate) from day 2 of the menstrual cycle. Among them, 70 patients received intrauterine PRP instillation on days 7, 9, and 11 of the cycle, while the remaining 30 patients did not undergo this treatment. Endometrial thickness was monitored, and progesterone was initiated on day 14 or once endometrial thickness surpassed 7 mm, followed by blastocyst transfer on day 6 of progesterone. Pregnancy outcomes were assessed using urine pregnancy tests or serum beta human chorionic gonadotropin levels followed by ultrasound to confirm fetal viability. The main outcomes assessed were improvement in endometrial thickness and clinical pregnancy rate.</div></div><div><h3>Results</h3><div>The administration of PRP through intrauterine instillation significantly increased mean endometrial thickness in the PRP group compared to the non-PRP group (p = 0.032). The clinical pregnancy rate was 35.71 % in the PRP group versus 10 % in the non-PRP group (p = 0.0251). No adverse reactions were observed.</div></div><div><h3>Conclusions</h3><div>PRP therapy significantly enhances endometrial receptivity and improves pregnancy outcomes in patients with refractory thin endometrium. It offers a promising adjunctive treatment for patients facing repeated cycle cancellations in frozen embryo transfer.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"315 ","pages":"Article 114758"},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}