Danilo Cimadomo , Mauro Cozzolino , Andrea Busnelli , Andea Carosso , Alessandro Conforti , Claudia Massarotti , Valentina Spadoni , Alberto Vaiarelli , Roberta Venturella , Amerigo Vitagliano , Carlotta Zacà , Andrea Borini
{"title":"IVF add-ons: effectiveness, efficiency, safety, and additional costs – A position statement by the SIFES-MR","authors":"Danilo Cimadomo , Mauro Cozzolino , Andrea Busnelli , Andea Carosso , Alessandro Conforti , Claudia Massarotti , Valentina Spadoni , Alberto Vaiarelli , Roberta Venturella , Amerigo Vitagliano , Carlotta Zacà , Andrea Borini","doi":"10.1016/j.ejogrb.2025.114609","DOIUrl":"10.1016/j.ejogrb.2025.114609","url":null,"abstract":"<div><h3>Objective</h3><div>To critically appraise IVF add-ons, based on current evidence, international recommendations, and expert consensus from SIFES-MR.</div></div><div><h3>Study design</h3><div>Consensus developed by a multidisciplinary panel of Italian reproductive medicine experts over two years, based on clinical expertise, revision of guidelines from ESHRE, HFEA, ISAR, and ASRM, and additional more recent references retrieved from the literature. A list of statements was produced and agreed upon the panel using a Delphi consensus workflow. The manuscript was circulated to SIFES-MR executive committee and society members for final approval. Add-ons were categorized by their putative impact on IVF efficacy, efficiency, or safety. Cost justification and patient communication were also considered.</div></div><div><h3>Results</h3><div>While some add-ons, such as preimplantation genetic testing for aneuploidies (PGT-A) in select patient populations, demonstrate potential clinical benefits, others lack sufficient evidence or pose safety concerns. Several interventions, including endometrial receptivity testing and mitochondrial DNA load measurement, are not currently recommended. Cost considerations and patient counseling are crucial.</div></div><div><h3>Conclusions</h3><div>The SIFES-MR panel underscores the importance of evidence-based practice in ART. Clear patient communication, fundamental research, and regulatory oversight are essential to ensure IVF add-ons provide real clinical benefits rather than unnecessary financial burdens.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114609"},"PeriodicalIF":1.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minh Tam Le , Nhu Quynh Thi Tran , Trung Van Nguyen , Quoc Huy Vu Nguyen
{"title":"Effects of reactive oxygen species in follicular fluid on embryo quality in cases with endometrioma","authors":"Minh Tam Le , Nhu Quynh Thi Tran , Trung Van Nguyen , Quoc Huy Vu Nguyen","doi":"10.1016/j.ejogrb.2025.114620","DOIUrl":"10.1016/j.ejogrb.2025.114620","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyse levels of reactive oxygen species (ROS) in follicular fluid in patients with endometrioma, and determine their effect on embryo quality and other relevant influencing factors in in-vitro fertilization (IVF) cycles.</div></div><div><h3>Methods</h3><div>This case–control study was conducted from January 2022 to October 2023 at Hue Centre for Reproductive Endocrinology and Infertility, Hue University Hospital, Vietnam. Enrolled patients undergoing IVF therapy were divided into two groups with a 1:1 ratio: the study group and the control group. Patients diagnosed with endometrioma comprised the study group. The control group included infertile women without ovarian tumours and without low ovarian reserve (POSEIDON criteria). Couples who used a sperm donor were not included in either group.</div></div><div><h3>Results</h3><div>Forty patients with endometrioma indicated for IVF were recruited into the study group, and an additional 40 patients without endometrioma were selected for the control group. The mean ± standard deviation levels of ROS in follicular fluid in the study group and the control group were comparable at 85.4 ± 28.0 mV and 94.7 ± 20.1 mV, respectively (<em>p</em> = 0.09). The mean fertilization rate in the study group was significantly lower compared with the control group (62.5 % vs 74.5 %; <em>p</em> = 0.032). In the study group, women who also had comorbidity with adenomyosis had a significantly lower total antral follicle count, and numbers of zygotes and blastocysts (<em>p</em> < 0.05). Further examination revealed that endometriosis did not affect the fertilization rate, blastocyst rate or good-quality blastocyst rate (<em>p</em> > 0.05). When considering intervention modalities, the surgical group exhibited the fewest blastocysts overall.</div></div><div><h3>Conclusion</h3><div>Endometrioma has no impact on ROS in follicular fluid. Fertilization rate, blastocyst rate and IVF outcomes were unaffected by ROS status in patients with endometrioma.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114620"},"PeriodicalIF":1.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Senjuti Dasgupta , Uma Banerjee , Partha Mukhopadhyay , Biplab Das , Saswata Saha
{"title":"Placental expression of Annexin A5, Apelin, and Caspase-3 in gestational hypothyroidism: A clinicopathological study","authors":"Senjuti Dasgupta , Uma Banerjee , Partha Mukhopadhyay , Biplab Das , Saswata Saha","doi":"10.1016/j.ejogrb.2025.114616","DOIUrl":"10.1016/j.ejogrb.2025.114616","url":null,"abstract":"<div><h3>Background</h3><div>Gestational hypothyroidism causes derangements in placental development. The novel markers, annexin A5 (ANXA5) and apelin play significant roles in placental health and disease. Caspase-3 is a pro-apoptotic protein which also modulates placental homeostasis.</div></div><div><h3>Objectives</h3><div>The objectives of the current study were to compare gross, histopathological findings and immunohistochemical expression of ANXA5, apelin, and caspase-3 of hypothyroid placentae with those of matched controls. These findings were also correlated with clinical features of the cases. The aim was also to explore the interconnection between the three markers, ANXA5, apelin and caspase-3.</div></div><div><h3>Methods</h3><div>A prospective, observational study was undertaken for a period of one year. Placentae of gestational hypothyroidism were collected along with their matched controls. The sample size was 56. The gross and microscopic features, as well as immunohistochemical expression of ANXA5, apelin, and caspase-3 in hypothyroid placentae were noted.</div></div><div><h3>Results</h3><div>Hypothyroid placentae showed significant histopathological changes, including fibrinoid necrosis, stromal fibrosis, syncytial knots, and cytotrophoblastic proliferation. Compared with controls, they exhibited significantly lower ANXA5 and apelin expression and higher caspase-3 expression, suggesting interrelated regulatory mechanisms.</div></div><div><h3>Conclusion</h3><div>This study explores the patterns of expression of ANXA5, apelin and caspase-3 in placentae of cases of gestational hypothyroidism. The inter-relationship of the markers with one another and that of the markers with clinical features, contribute to better understanding of the pathophysiology of gestational hypothyroidism.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114616"},"PeriodicalIF":1.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gioia Mastromoro , Daria Darelli , Stefania Mariani , Flavia Colantoni , Serena Bucossi , Michela Canestrelli , Claudio Dello Russo , Rosanna Squitti , Alessia Micalizzi , Andrea Zumpano , Antonio Pizzuti , Mauro Ciro Antonio Rongioletti
{"title":"Microduplication encompassing CCL2 segregates in a family with recurrent anencephaly and dorsal dermal sinus: a possible link between chemokine and neural tube defects?","authors":"Gioia Mastromoro , Daria Darelli , Stefania Mariani , Flavia Colantoni , Serena Bucossi , Michela Canestrelli , Claudio Dello Russo , Rosanna Squitti , Alessia Micalizzi , Andrea Zumpano , Antonio Pizzuti , Mauro Ciro Antonio Rongioletti","doi":"10.1016/j.ejogrb.2025.114617","DOIUrl":"10.1016/j.ejogrb.2025.114617","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114617"},"PeriodicalIF":1.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Avir Sarkar , Amiya Das , Subrat Panda , Shivam Pandey , Lisley Konar , Pooja Meena , Bijoya Mukherjee , Anshul Rana , Suman Sandeep Samal , Zakir Hussain
{"title":"Fetal adrenal gland measurements as indicators of glycaemic control in gestational diabetes mellitus: A systematic review of observational studies","authors":"Avir Sarkar , Amiya Das , Subrat Panda , Shivam Pandey , Lisley Konar , Pooja Meena , Bijoya Mukherjee , Anshul Rana , Suman Sandeep Samal , Zakir Hussain","doi":"10.1016/j.ejogrb.2025.114619","DOIUrl":"10.1016/j.ejogrb.2025.114619","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review aims to evaluate the association between fetal adrenal gland measurements and maternal glycaemic control in pregnancies complicated by gestational diabetes mellitus (GDM). The review also considers the potential role of these measurements as indicators of fetal well-being and intrauterine stress, with the goal of enhancing current monitoring strategies in GDM pregnancies.</div></div><div><h3>Materials and methods</h3><div>A comprehensive literature search was conducted across several major databases, including PubMed, Scopus, Embase, Google Scholar and ClinicalTrials.gov. Studies were selected based on their investigation of fetal adrenal gland morphology, size or function in the context of maternal GDM and its glycaemic control. Inclusion criteria encompassed original research—both prospective and retrospective—reporting on imaging-based assessments of the fetal adrenal glands and their correlation with maternal glucose regulation, typically measured by blood glucose profiles or HbA1c levels. Relevant data were systematically extracted and analyzed, including study characteristics, diagnostic criteria for GDM, imaging modalities, fetal adrenal findings, and clinical outcomes.</div></div><div><h3>Results</h3><div>Five studies met the inclusion criteria and were included in the final analysis. A total of 844 participants were studied in these five studies. Overall, findings indicated a potential association between impaired glycaemic control and alterations in fetal adrenal gland morphology. In pregnancies where maternal glucose levels were poorly managed, changes such as increased adrenal gland size, altered cortex-to-medulla ratios and abnormal echogenicity were commonly observed. These changes may reflect heightened fetal hypothalamic–pituitary–adrenal (HPA) axis activity, potentially in response to intrauterine stress. In contrast, well-controlled GDM pregnancies were generally associated with fetal adrenal parameters within normal limits. A number of studies also linked these adrenal alterations to adverse neonatal outcomes, including macrosomia, neonatal hypoglycemia, and delivery complications.</div></div><div><h3>Conclusion</h3><div>Fetal adrenal gland evaluation may offer valuable insight into fetal physiological responses to maternal metabolic conditions, particularly in the context of gestational diabetes. The observed relationship between abnormal adrenal findings and poor maternal glycaemic control suggests that these measurements could serve as a useful, non-invasive marker of fetal stress or compromised well-being. However, the current evidence base is limited by methodological inconsistencies, small sample sizes and variability in imaging techniques. Further large-scale, standardized studies are necessary to validate the clinical relevance and predictive value of fetal adrenal gland assessment in the management of GDM pregnancies.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114619"},"PeriodicalIF":1.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of Z-score-based models to predict perinatal mortality in pregnancies complicated by fetal growth restriction managed at a tertiary care hospital","authors":"Oswaldo Tipiani , Esperanza Arce","doi":"10.1016/j.ejogrb.2025.114612","DOIUrl":"10.1016/j.ejogrb.2025.114612","url":null,"abstract":"<div><h3>Objective</h3><div>To develop predictive models using fetal weight Z-scores to predict perinatal mortality in pregnancies affected by fetal growth restriction (FGR) in high-risk settings.</div><div><strong>Study Design:</strong> This retrospective cohort included singleton pregnancies without congenital anomalies, delivered after 30 weeks of gestation in a tertiary hospital between 2019 and 2022. FGR was defined as weight below the 3rd percentile according to three fetal growth charts. Optimal Z-score cutoffs were identified to maximize sensitivity and specificity for perinatal mortality. Logistic regression models incorporated dichotomized Z-scores and significant predictors. Model performance was assessed using ROC curves, calibration plots, and decision curve analysis (DCA).</div></div><div><h3>Results</h3><div>Among 17 991 singleton pregnancies, 16 177 met the inclusion criteria. FGR was identified in 369 (2.3 %), 157 (1.0 %), and 335 (2.1 %) foetuses using the Hadlock, INTERGROWTH-21st (IG-21), and local customized charts, respectively. Perinatal mortality occurred in 30/369 (8.1 %), 25/157 (15.9 %), and 31/335 (9.3 %) of these groups. Z-score thresholds (−2.61, −3.17, −2.95) showed strong predictive capacity, with adjusted AUCs of 0.878, 0.884, and 0.917. The final model was logit(p) = β<sub>0</sub> + β<sub>1</sub>Z-score − β<sub>2</sub> Gestational age − β<sub>3</sub> Preeclampsia (preeclampsia excluded in IG-21). Calibration errors averaged 0.02, 0.04, and 0.02; adjusted odds ratios were 18.7, 37.6, and 23.7. The decision curve analysis suggests that integrating these models into clinical protocols may enhance perinatal risk stratification.</div></div><div><h3>Conclusion</h3><div>Three Z-score-based models accurately predicted perinatal mortality in FGR-complicated pregnancies in a high-risk setting. Their integration into clinical protocols may support individualized risk stratification and decision-making.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114612"},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kemal Güngördük , Onur Arslaner , Berican Şahin Uyar , Emre Biton , Berke Nur Ergü , Varol Gülseren
{"title":"Effectiveness of perioperative duloxetine for pain management in vNOTES hysterectomy: a randomized, placebo-controlled trial duloxetine for perioperative pain control in vNOTES hysterectomy","authors":"Kemal Güngördük , Onur Arslaner , Berican Şahin Uyar , Emre Biton , Berke Nur Ergü , Varol Gülseren","doi":"10.1016/j.ejogrb.2025.114594","DOIUrl":"10.1016/j.ejogrb.2025.114594","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the impact of perioperative administration of duloxetine on postoperative pain management and recovery quality in women undergoing vNOTES total hysterectomy.</div></div><div><h3>Methods</h3><div>Conducted as a randomized controlled trial, the study involved 76 women divided into two groups—39 in the study group and 37 in the control group. Patients in the study group received 60 mg of oral duloxetine 2 h prior to surgery and again 24 h post-surgery, whereas those in the control group were given a placebo following the same schedule. While medical staff were aware of the treatment allocations, all patients remained blinded to the type of medication administered.</div></div><div><h3>Results</h3><div>No differences were observed between the patients in terms of baseline demographics or perioperative characteristics. Eight hours after surgery, the study group demonstrated a significantly lower mean visual analog scale (VAS) pain score compared to the placebo group (4.4 ± 0.7 vs. 3.7 ± 1.0, P = 0.002). Additionally, the mean VAS scores at 4, 12, and 24 h post-surgery were also significantly lower in the study group. The mean scores on the faces pain scale-revised consistently showed reductions in the duloxetine group as well. A smaller proportion of patients in the duloxetine group required rescue analgesics (25.6 % versus 45.9 %, P = 0.033). Women treated with duloxetine attained significantly higher scores on the overall QoR-15 questionnaire (111.4 ± 5.0 vs. 104.8 ± 5.5, P < 0.001). No notable differences in adverse outcomes were observed between the duloxetine and placebo groups.</div></div><div><h3>Conclusion</h3><div>Administering duloxetine as premedication for patients undergoing V-notes hysterectomy is a safe and effective approach to minimizing postoperative pain, reducing the need for additional analgesics, and enhancing patient satisfaction. Therefore, this strategy can be incorporated into an enhanced recovery protocol.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114594"},"PeriodicalIF":1.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabrizio Zullo , Teresa C. Logue , Daniele Di Mascio , Giuseppe Rizzo , Antonella Giancotti , Matthew K. Hoffman , Sara Sorrenti , Hector Mendez Figueroa , Anthony C. Sciscione , Michal Fishel Bartal , Suneet P. Chauhan
{"title":"Parturients with diabetes and associated outcomes with Macrosomic newborns","authors":"Fabrizio Zullo , Teresa C. Logue , Daniele Di Mascio , Giuseppe Rizzo , Antonella Giancotti , Matthew K. Hoffman , Sara Sorrenti , Hector Mendez Figueroa , Anthony C. Sciscione , Michal Fishel Bartal , Suneet P. Chauhan","doi":"10.1016/j.ejogrb.2025.114598","DOIUrl":"10.1016/j.ejogrb.2025.114598","url":null,"abstract":"<div><h3>Background</h3><div>Adverse neonatal and maternal outcomes are understudied for parturients with diabetes who deliver macrosomic newborns.</div></div><div><h3>Objective</h3><div>We hypothesized that composite-neonatal (CNAO) and maternal adverse outcomes (CMAO) would be significantly higher for individuals with diabetes macrosomic newborns.</div><div><strong>Study Design:</strong> This was a secondary analysis of APEX cohorts. The inclusion criteria were parturients with diabetes that were at least 34.0 weeks. CNAO included: Apgar score < 7 at 5 min, neonatal fracture, intracranial hemorrhage, neonatal brachial plexus palsy (NBPP), treated hypotension, or hypoxic encelopathy. CMAO included: chorioamnionitis, EBL ≥ 1,000 mL or 3rd/4th degree lacerations. Multivariate Poisson regression with robust error variance was used to calculate incidence-rate-ratios (IRR), and adjusted IRR (aIRR)</div></div><div><h3>Results</h3><div>Among the 118,422 cohorts in APEX study, 8,410(7.5 %) had diabetes. The inclusion criteria were met by 584 (6.9 %) diabetic parturients, and among them 491 (84.0 %) delivered category I macrosomia, and 93 (16.0 %) with category II/III. The overall CNAO was 7.2 %, and it was significantly higher for parturients who delivered newborns with BW ≥ 4,500 g (15.0%) versus 4,000–4,499 g (5.7%; aIRR2.64; 95 %-CI 1.39–5.01; p: 0.006). The overall CMAO was 29.9 % and it was similar when BW ≥ 4,500 g (32.2 %) versus when BW was 4,000–4,499 (29.5 %; aIRR 1.05; 0.71–1.57). The overall rate of shoulder dystocia (SD) among macrosomic newborns was 14.7 % and it was significantly higher among those with birthweight ≥ 4,500g (28.0%) versus those with 4,000–4,449 g (12.2 %; aIRR2.21; 95 %CI 1.39–3.53). The rate of cesarean delivery did not differ between the two groups(aIRR 1.24;95 % CI 0.89–1.72).</div></div><div><h3>Conclusions</h3><div>Among parturients with diabetes, who delivered newborns with birthweight ≥ 4,500 g versus 4,000–4,499 g, CNAO and SD were twofold higher. Thus, there is an imperative to identify newborns among individuals with diabetes whose newborn will be 4,000–4,499 versus ≥ 4,500 g.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"313 ","pages":"Article 114598"},"PeriodicalIF":1.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inside Back Cover - Editors with images","authors":"","doi":"10.1016/S0301-2115(25)00880-2","DOIUrl":"10.1016/S0301-2115(25)00880-2","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"312 ","pages":"Article 114604"},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}