European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Impact of second trimester iron deficiency on maternal and infant outcomes: A Danish cohort study","authors":"Celina Pforr Ibsen ,&nbsp;Cathrine Scavenius ,&nbsp;Katrine Dige Frederiksen ,&nbsp;Laura Wonsbek ,&nbsp;Ida Lise Arevad Ammitzbøll ,&nbsp;Fie Juhl Vojdeman ,&nbsp;Andreas Glenthøj ,&nbsp;Mette Calundann Noer ,&nbsp;Jeannet Lauenborg ,&nbsp;Camilla Maria Mandrup ,&nbsp;Tine Dalsgaard Clausen","doi":"10.1016/j.ejogrb.2025.114004","DOIUrl":"10.1016/j.ejogrb.2025.114004","url":null,"abstract":"<div><h3>Objective</h3><div>Iron is a fundamental component during pregnancy; however, there is a lack of understanding of how iron deficiency (ID) during the second trimester affects maternal and infant outcomes. We aimed to investigate the prevalence of ID among pregnant women during the second trimester of pregnancy and to evaluate the associations with adverse maternal and infant outcomes.</div></div><div><h3>Study design</h3><div>This was an exploratory analysis of data from a longitudinal cohort study including singleton pregnant women at a single center, where P-ferritin was analyzed in blood samples drawn between 24 and 28 weeks gestation. Multivariable regression analyses with Bonferroni corrections were used to evaluate the association between ID (P-ferritin &lt;15 µg/L) in the second trimester and maternal and infant outcomes.</div></div><div><h3>Results</h3><div>Second trimester ID was found in 182 of the 449 included women (40.5 %), among whom anemia was present in 4.4 %. Women with ID were more often multiparous (73.1 % vs. 52.4 %) and subsequently treated with intravenous iron infusion (5.5 % vs. 1.1 %). Infants born to women with ID had a significantly higher placental weight (700 g vs. 630 g), higher birth weight (3713 g vs. 3522 g), birth weight z-score (0.3 vs. −0.1), and significantly lower prevalence of small for gestational age (2.7 % vs. 9.8 %) compared to women with normal iron levels. ID in the second trimester of pregnancy was not associated with adverse maternal or infant outcomes such as emergency cesarean section, induction of labor, preterm birth, or fetal acidosis.</div></div><div><h3>Conclusion</h3><div>Despite recommended iron supplements from 10 weeks gestation, ID was frequent among pregnant Danish women in the second trimester and associated with accelerated placental and infant growth, but not adverse pregnancy outcomes. This study indicates that the clinical relevance of the current cut-off level for ID in the second trimester of pregnancy among pregnant Danish women needs further investigation.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114004"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on perinatal outcomes in First Nations and all other mothers and their offspring in Manitoba","authors":"Amy Hui ,&nbsp;Roxana Dragan ,&nbsp;Elizabeth Decaire ,&nbsp;Vivian Omarr ,&nbsp;Connie Kuzdak ,&nbsp;Jennifer Yamamoto ,&nbsp;Brandy Wicklow ,&nbsp;Elizabeth Sellers ,&nbsp;Jonathan McGavock ,&nbsp;Christy Pylypjuk ,&nbsp;Nathan Nickel ,&nbsp;Depeng Jiang ,&nbsp;Garry X. Shen","doi":"10.1016/j.ejogrb.2025.114006","DOIUrl":"10.1016/j.ejogrb.2025.114006","url":null,"abstract":"<div><h3>Purpose of research</h3><div>COVID-19 substantially disrupted healthcare, but its impact on perinatal outcome in Manitoba remains unclear.</div></div><div><h3>Methods</h3><div>The present study examined perinatal outcomes in First Nations and all other women and infants in Manitoba during COVID-19 (March 2020-December 2021) compared to a control period (March 2018-March 2020) using a retrospective database study.</div></div><div><h3>Principal results</h3><div>First Nations pregnancies had significantly higher rates of gestational diabetes, pre-pregnancy diabetes (PPD), preterm birth, stillbirth, large-for-gestational-age infants, neonatal intensive care unit (NICU) admission and formula feeding, and lower rates of exclusive breastfeeding compared to all other pregnancies during COVID-19 or the control period. Age-adjusted odds ratio (aORs) for preterm birth (aOR 1⋅17, 95% confidence interval or CI: 1⋅06, 1⋅30) and shoulder dystocia (aOR 1⋅33, 95% CI: 1⋅08, 1⋅64) among First Nations, but not all other, newborns were increased during COVID-19 compared to the control period. The aORs for preeclampsia, eclampsia, and spontaneous abortion were increased in all other, but not First Nations, pregnancies during COVID-19 versus the control period. Logistic linear regression analyses indicated that PPD was the leading contributor to the increase of preterm birth, stillbirth, shoulder dystocia and NICU admission.</div></div><div><h3>Conclusions</h3><div>The findings imply that COVID-19 caused more profound adverse neonatal outcomes in First Nations offspring. Maternal diabetes played an important role in the unfavorable neonatal outcomes. Prevention of maternal diabetes by strengthening perinatal education and care may help to reduce the risk of adverse neonatal outcomes in First Nations population in future pandemic.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114006"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare encounter with fetus papyraceus at term cesarean delivery","authors":"Seepana Manasa,&nbsp;Vijayan Sharmila,&nbsp;Vandana Kamatham,&nbsp;Kumbha Siva Naga Jyothi","doi":"10.1016/j.ejogrb.2025.114009","DOIUrl":"10.1016/j.ejogrb.2025.114009","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114009"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of “Impact of human papillomavirus 9-valent vaccine on viral clearance after surgical treatment: A single-center retrospective observational study”","authors":"Ahmed Mueed,&nbsp;Faryal Amjad","doi":"10.1016/j.ejogrb.2025.114013","DOIUrl":"10.1016/j.ejogrb.2025.114013","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114013"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vaginal microbiota and preterm birth: A systematic review","authors":"Margherita Ferrante ,&nbsp;Gea Oliveri Conti ,&nbsp;Eloise Pulvirenti ,&nbsp;Claudia Favara ,&nbsp;Maria Fiore ,&nbsp;Antonio Cristaldi","doi":"10.1016/j.ejogrb.2025.114007","DOIUrl":"10.1016/j.ejogrb.2025.114007","url":null,"abstract":"<div><div>Vaginal microbiota is a dynamic community of bacteria, fungi, and viruses that colonize the lower genital tract. Changes in vaginal microbiota can result in obstetric complication. For example, a reduction in Lactobacilli can lead to bacterial vaginosis, which is associated with preterm birth.</div><div>We performed a systematic review to investigate the association between vaginal microbiota composition during pregnancy and preterm birth risk.</div><div>Scopus, Web of Science, PubMed databases were used to find published studies on the topic. The search period was between January 2014 and June 2024. A total of 2194 full research articles were screened, and finally, we included 14 full-research articles.</div><div>Demographic factors, such as self-identified ethnicity, age, substance use, and gestational age, influence the vaginal microbiota were identified. The greatest diversity in the composition of the vaginal microbiota was found between the first and second trimesters of pregnancy. We found a decrease in <em>L. crispatus</em>, <em>L. gasseri</em> and <em>L. jensenii</em> population, with a relative increase in <em>L. iners,</em> which were associated with preterm birth. In addition, <em>Ureaplasma</em>, <em>Mycoplasma</em>, and <em>Gardnerella</em> species were associated with increased rates of preterm birth. An increase in cytokines (IL-1β, IL-6, and MIP-1β) and a decrease in β-defensin-2 values also seem to influence the preterm birth onset.</div><div>In summary, we identified multiple vaginal microbiota that were associated with changes in the risk of preterm birth. Further studies should focus on demonstrating a causal relationship and identifying interventions to reduce the risk of preterm birth associated with changes in the vaginal microbiota.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114007"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Longitudinal changes of automated volumetric breast density with postmenopausal hormone therapy”","authors":"Qi Xu,&nbsp;Yuwan Gao","doi":"10.1016/j.ejogrb.2025.114014","DOIUrl":"10.1016/j.ejogrb.2025.114014","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114014"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Surgical correction of labial posterior commissure deformities: a follow-up study on alleviating superficial dyspareunia”","authors":"Venkata Dileep Kumar Veldi ,&nbsp;Rachana Mehta ,&nbsp;Ranjana Sah","doi":"10.1016/j.ejogrb.2025.114012","DOIUrl":"10.1016/j.ejogrb.2025.114012","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"310 ","pages":"Article 114012"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical and structural chromosomal anomalies in first trimester products of conception","authors":"Christina Katsidi ,&nbsp;Haroula Tsarouha ,&nbsp;Elisavet Kouvidi ,&nbsp;Leandros Lazaros ,&nbsp;Konstantinos Pantos ,&nbsp;Konstantinos Sfakianoudis ,&nbsp;Amelia Pantou ,&nbsp;Emmanuel Kanavakis ,&nbsp;Ariadni Mavrou ,&nbsp;Periklis Makrythanasis","doi":"10.1016/j.ejogrb.2025.114005","DOIUrl":"10.1016/j.ejogrb.2025.114005","url":null,"abstract":"<div><h3>Objective</h3><div>Multiple or complex chromosomal abnormalities are rare and are correlated with advanced maternal age and spontaneous abortion early in pregnancy. This study investigates the frequency of complex chromosomal abnormalities in products of conception in the first trimester of pregnancy.</div></div><div><h3>Study design</h3><div>473 samples from first trimester aborted tissues were analyzed with conventional cytogenetic or molecular techniques. The average maternal age was 39 years (range 23–55). From each sample at least ten metaphases were analyzed using standard GTG banding.</div></div><div><h3>Results</h3><div>From 351 fetal origin cultured samples diagnosis was possible at 339 (97 %). Abnormal karyotypes were detected in 216 embryos (64 %) and a normal karyotype was detected in 123 (36 %). Non-complex chromosomal abnormalities were detected in 192 cases (89 %) with single trisomy 16 being the most frequent and complex abnormalities were identified in 24 cases (11 %). Polyploidies and monosomy 45,X occurred in 8 % each. Structural rearrangements and mosaicism were detected in 2 % and 3 %, respectively. Statistical analysis showed association between the week of gestation of single and complex chromosomal abnormalities (p = 0.04136).</div></div><div><h3>Conclusions</h3><div>Our results confirm that embryos with complex chromosomal abnormalities were more frequent among older women (&gt;39 years old) and were aborted one week earlier than embryos with non-complex chromosomal abnormalities. Additionally, we have identified a higher number of complex chromosomal abnormalities (11 % vs 5–7 % in literature). Among complex chromosomal abnormalities, double trisomy was the most common finding, and the most frequent chromosomes involved were 21, X, and 15.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114005"},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of ifosfamide during pregnancy: A comprehensive analysis","authors":"Charlotte Devant ,&nbsp;Tessa Pietri ,&nbsp;Marine Auffret ,&nbsp;Laurence Lagarce ,&nbsp;Mathilde Barrois ,&nbsp;Jean-Marc Treluyer ,&nbsp;Vassilis Tsatsaris ,&nbsp;Laurent Chouchana","doi":"10.1016/j.ejogrb.2025.114003","DOIUrl":"10.1016/j.ejogrb.2025.114003","url":null,"abstract":"<div><h3>Objective</h3><div>Little is known regarding the safety of ifosfamide in pregnant women and some case reports were associated with oligohydramnios. In the study, we performed a comprehensive analysis of the available data regarding the safety of ifosfamide in pregnant women.</div></div><div><h3>Material and methods</h3><div>First, we performed a case-by-case review of the cases related to ifosfamide use during pregnancy that were spontaneously reported in the French Pharmacovigilance Database. Second, we reviewed cases from the literature. Finally, we performed a disproportionality analysis on VigiBase, the WHO global safety database (VigiBase), to assess the association between ifosfamide and selected adverse events in pregnant women.</div></div><div><h3>Results</h3><div>A total of 27 cases of ifosfamide use during pregnancy were identified. No congenital malformation was reported. Main adverse events were intrauterine growth restriction (n = 15, 56 %) and oligohydramnios or anhydramnios (n = 15, 56 %). Pregnancy resulted in intrauterine fetal death in 5 (19 %) cases, all being treated with ifosfamide before the 21th week of gestation. All livebirths (n = 22) were preterm, associated with neonatal acute renal failure in 5 (23 %) cases. In addition, 3 (14 %) neonatal deaths were reported within the first week of life in neonates having anuria. In VigiBase, which has over 263,145 spontaneous safety reports related to pregnancy, we found a significant increased reporting of oligohydramnios, intrauterine growth restriction and neonatal acute renal failure with ifosfamide compared to other antineoplastic agents.</div></div><div><h3>Conclusion</h3><div>Altogether, this comprehensive analysis supports that ifosfamide may induce fetal nephrotoxicity in pregnant women. It can result in intrauterine growth restriction, oligohydramnios and neonatal acute renal failure, as well as fetal death especially for early exposure during the first half of pregnancy.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"311 ","pages":"Article 114003"},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover - Editors with images","authors":"","doi":"10.1016/S0301-2115(25)00273-8","DOIUrl":"10.1016/S0301-2115(25)00273-8","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"309 ","pages":"Page IBC"},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}