European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Obturator nerve injury during robot-assisted laparoscopic pelvic lymphadenectomy: Literature review and case series","authors":"O.P. Van Marle,&nbsp;J.P. Hoogendam,&nbsp;R.P. Zweemer,&nbsp;C.G. Gerestein","doi":"10.1016/j.ejogrb.2026.114981","DOIUrl":"10.1016/j.ejogrb.2026.114981","url":null,"abstract":"<div><h3>Objective</h3><div>To describe a case series of patients with obturator nerve injury following pelvic lymphadenectomy (PLND) at the study centre, and provide a narrative review of the literature regarding the incidence, management and clinical course of obturator nerve injury after PLND.</div></div><div><h3>Methods</h3><div>A literature search was performed using PubMed and Google Scholar, applying the terms ‘obturator nerve injury’ and ‘lymph node dissection’, including relevant MeSH terms and synonyms. In addition, all patients with obturator nerve injury following robot-assisted laparoscopic PLND at the study centre between 1 January 2008 and 31 December 2023 were identified. Data regarding type of surgery, surgical repair technique, materials used, and postoperative course were collected. The primary outcome was recovery of motor and sensory function. Secondary outcomes included residual morbidity, the proportion of patients achieving full recovery within 1 year, and the need for additional surgical intervention.</div></div><div><h3>Results</h3><div>In total, 16 patients with obturator nerve injury following PLND were identified. In most cases, a primary end-to-end epineural anastomosis using 5–0 or 6–0 Prolene sutures was performed. In five patients, a primary anastomosis was not feasible, and nerve grafts or polyglycolic acid/collagen conduits were used. The majority of patients achieved full recovery within 3 months.</div></div><div><h3>Conclusion</h3><div>Obturator nerve injury is a rare complication of PLND. In most cases, primary end-to-end epineural repair can be performed to restore nerve continuity, and this is associated with a favourable clinical course. While most patients recover within 3 months, residual motor deficits may persist in a subset of cases. These findings should be interpreted as descriptive, as comparative evidence regarding surgical techniques and materials remains limited.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114981"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal encephalopathy requiring therapeutic hypothermia over 5 years in a national Irish birth cohort: Relevance of the obstetric data","authors":"Aenne Helps ,&nbsp;Indra Lazaro Campillo ,&nbsp;Paul Corcoran ,&nbsp;Julie McGinley ,&nbsp;Richard Greene ,&nbsp;John Murphy ,&nbsp;Peter McKenna","doi":"10.1016/j.ejogrb.2026.114982","DOIUrl":"10.1016/j.ejogrb.2026.114982","url":null,"abstract":"&lt;div&gt;&lt;div&gt;&lt;strong&gt;Background&lt;/strong&gt;: Neonatal encephalopathy, often due to peripartum hypoxia–ischemia, remains a significant cause of neonatal morbidity and mortality. Therapeutic hypothermia is the established treatment for moderate and severe neonatal encephalopathy in Ireland since 2012 after publication of an international trial. Despite adherence to strict clinical criteria, the maternal and obstetric factors associated with infants requiring therapeutic hypothermia remain incompletely understood.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Objectives&lt;/strong&gt;: To describe maternal and infant characteristics among infants treated with therapeutic hypothermia in Ireland over five years, and to assess whether obstetric factors are associated with increased risk of neonatal encephalopathy.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Study design&lt;/strong&gt;: A population-based, retrospective cohort study of all infants (n = 357) who received therapeutic hypothermia in Ireland from 2016 to 2020 was conducted. Data were collected from 19 maternity units and compiled into a national register. The study compared antenatal and intrapartum characteristics between therapeutic hypothermia cases and the national birthing population. Risks per 1,000 births and their exact Poisson 95% confidence intervals and risk ratios (RR) and their 95% CI were the primary statistical measures reported.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Results&lt;/strong&gt;: The incidence of therapeutic hypothermia was 1.18 per 1,000 live births (357/301,442), with some evidence of increase over time (RR for 2020 vs 2016 = 1.36, CI: 0.98–1.90; p = 0.068). Infants born to nulliparous women had a more than twofold higher risk of receiving therapeutic hypothermia (1.79 vs 0.80 per 1,000; RR = 2.25, CI: 1.82–2.77; p &lt; 0.001). Therapeutic hypothermia risk increased significantly with maternal obesity (RR = 1.65) and fetal growth restriction (RR = 2.74 for &lt; 3rd centile; RR = 1.99 for 4th–10th centile). Emergency caesarean section was associated with the highest therapeutic hypothermia risk. Sentinel events such as shoulder dystocia (n = 42; 11.8%), placental abruption (n = 20; 5.6%), and uterine rupture (n = 12; 3.4%) were significantly associated with therapeutic hypothermia (shoulder dystocia RR = 17.48, CI: 12.67–24.12; p &lt; 0.001). Overall, 14% (50/357) of infants died. Among those followed up with Bayley-III testing (n = 85), 21.2% had motor, 16.5% cognitive, and 28.2% language delays.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; Infants born to nulliparous women, those exposed to maternal obesity, fetal growth restriction and emergency caesarean section birth were at increased risk of requiring therapeutic hypothermia. Sentinel events, while strongly associated with therapeutic hypothermia, were infrequent, suggesting cumulative or dynamic perinatal factors play a critical role. These findings underscore the importance of enhanced intrapartum monitoring and structured clinical response systems to reduce avoidable neonatal encephalopathy cases in Ireland","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114982"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern \"A randomized comparison of a single-incision needleless (Contasure-needleless®) mini-sling versus a mid-urethral sling (Contasure-KIM®): 60-month follow-up results\". [Eur. J. Obstet. Gynecol. Reprod. Biol. 307C (2025) 7-12].","authors":"Ozan Dogan, Pinar Kadirogullari, Erhan Huseyin Comert, Alper Basbug, Murat Yassa","doi":"10.1016/j.ejogrb.2026.114971","DOIUrl":"10.1016/j.ejogrb.2026.114971","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"114971"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical cord diameter and cross-sectional area in association with gestational age among women with uncomplicated pregnancies in north-central Nigeria: a cross-sectional study","authors":"Musa A. Muslimah ,&nbsp;Halimat J. Akande ,&nbsp;Hadijat O. Raji ,&nbsp;Bola B. Olafimihan ,&nbsp;Latifat T. Aremu ,&nbsp;James I. Owolabi ,&nbsp;Sadiya M. Gwadabe ,&nbsp;Idris O. Quadri","doi":"10.1016/j.ejogrb.2026.114976","DOIUrl":"10.1016/j.ejogrb.2026.114976","url":null,"abstract":"<div><h3>Aim and objectives</h3><div>To assess gestational age using the umbilical cord diameter (UCD) and cross-sectional area (CSA).</div></div><div><h3>Methodology</h3><div>This was a cross-sectional study among 300 women with no adverse medical history and uncomplicated pregnancies between the 14th and 40th completed weeks of pregnancy. The commonly used foetal parameters for gestational age (GA) estimation: Biparietal Diameter, Head and Abdominal Circumference and Femur Length were measured using standard protocols.</div><div>UCD and CSA were measured in a plane adjacent to cord insertion into the foetal abdomen within 1 cm. UCD was measured in long axis from outer-to-outer border of the umbilical cord using the electronic calipers. The cross-sectional area was obtained in transverse axis using the ellipse measurement and area was calculated automatically by the ultrasound machine in-built software. Measurements were taken twice for each parameter, and the average value was recorded for each participant to reduce intra-observer error.</div></div><div><h3>Result</h3><div>The mean UCD and CSA were 16.12 ± 4.28 mm and 2.08 ± 0.87 cm² respectively. UCD and CSA were observed to increase steadily with GA up to the 33rd week of gestation, decline and then remain stable from the 38th and 39th week gestation respectively until the end of pregnancy. Significant correlations (p = 0.001) between umbilical cord diameter and cross-sectional area with estimated foetal weight (EFW), GA and other foetal parameters for GA estimation was observed.</div><div>A regression analysis model between UCD, CSA and GA showed 95% confidence interval (CI). GA by LMP (weeks) = 1.528 (UCD) + 2.646, 7.544 (CSA) + 11.540. GA by US (weeks) = 1.542 (UCD) + 2.653, 7.618 (CSA) + 11.619.</div></div><div><h3>Conclusion</h3><div>UCD and CSA measurement is a reliable method for prediction of GA and has a strong linear relationship with commonly used foetal parameters.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114976"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which body region’s fat accumulation increase the risk of stress urinary incontinence?","authors":"Ana Jéssica dos Santos Sousa ,&nbsp;Stela Márcia Mattiello ,&nbsp;Ana Paula Rodrigues Rocha ,&nbsp;Alessander Danna-Dos-Santos ,&nbsp;Patricia Driusso","doi":"10.1016/j.ejogrb.2026.114957","DOIUrl":"10.1016/j.ejogrb.2026.114957","url":null,"abstract":"<div><div>The objective of this cross-sectional study was to examine the association between fat mass distribution and stress urinary incontinence (SUI) symptoms, as well as the impact of SUI on daily activities. We assessed sociodemographic characteristics, urinary symptoms, and fat mass (total, android, gynoid, and visceral adipose tissue [VAT]). Descriptive statistics, independent t tests, and univariable and multivariable regression analyses were conducted. Women with SUI exhibited significantly higher total, android, gynoid, and VAT fat mass than women without urinary incontinence (p &lt; 0.05). Increases in total, android, gynoid, and VAT fat mass were associated with higher odds of SUI by 0.4%, 4.4%, 2.6%, and 31.4%, respectively. VAT fat mass was particularly influential, increasing the likelihood of SUI by 51% (odds ratio [OR] 1.51; 95% CI). Greater VAT accumulation was also associated with a 16.0% increase in discomfort related to urinary symptoms and a 9.3% increase in the impact on daily activities among women with SUI. In summary, higher adiposity in the android, gynoid, and especially VAT regions are associated with an increased likelihood of SUI and with greater symptom-related discomfort and functional impact.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114957"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An individual participant data network meta-analysis of the APOSTEL trials on the effect of tocolysis in threatened preterm birth between 30–33+6 weeks of gestation in twin pregnancies","authors":"L. van Gils ,&nbsp;L.I. van der Windt ,&nbsp;A.H. van Kaam ,&nbsp;C. Roos ,&nbsp;E. Pajkrt ,&nbsp;M.A. Oudijk","doi":"10.1016/j.ejogrb.2026.114989","DOIUrl":"10.1016/j.ejogrb.2026.114989","url":null,"abstract":"<div><h3>Objective</h3><div>Twin pregnancies have a substantial risk of preterm birth, but evidence on tocolytics is limited. We evaluated whether nifedipine or atosiban improves neonatal outcomes compared with placebo.</div></div><div><h3>Design</h3><div>Individual participant data network <em>meta</em>-analysis (IPD-NMA) of two international multicentre randomised controlled trials (APOSTEL 3 and 8).</div></div><div><h3>Setting</h3><div>The APOSTEL-3 compared nifedipine with atosiban, while the APOSTEL-8 compared atosiban with placebo.</div></div><div><h3>Population</h3><div>Women with twin pregnancies and threatened preterm birth between 30⁺⁰ and 33⁺⁶ weeks.</div></div><div><h3>Methods</h3><div>Analyses were performed at the infant level using generalised estimating equations to account for clustering within twin pairs.</div></div><div><h3>Main outcome measures</h3><div>Adverse neonatal outcome: composite of neonatal morbidity or mortality.</div></div><div><h3>Results</h3><div>A total of 179 women were included: 94 allocated to atosiban, 27 to nifedipine, and 58 to placebo. Prolongation beyond 48 h was not significantly increased with nifedipine (RR 0.96, 95% CI 0.68–1.36) or atosiban (RR 1.10, 95% CI 0.88–1.38). The composite adverse neonatal outcome occurred in 3.7% of neonates in the nifedipine group (2/54), 7.5% in the atosiban group (14/188), and 5.2% in the placebo group (6/116). Relative risks were 0.72 (95% CI 0.15–3.43) for nifedipine <em>vs</em> placebo, 1.44 (95% CI 0.57–3.64) for atosiban <em>vs</em> placebo, and 2.01 (95% CI 0.47–8.58) for atosiban <em>vs</em> nifedipine.</div></div><div><h3>Conclusion</h3><div>No clear benefit of nifedipine or atosiban over placebo on neonatal outcomes in twin pregnancies with threatened preterm birth between 30⁺⁰ and 33⁺⁶ weeks was found.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114989"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy in thin endometrium and Asherman’s syndrome: a systematic review and meta-analysis","authors":"Leila Adamyan ,&nbsp;Laura Pivazyan ,&nbsp;Maria Yurkanova ,&nbsp;Veronika Tarlakyan ,&nbsp;Elizaveta Platonova ,&nbsp;Agnessa Osipova ,&nbsp;Karina Mailova ,&nbsp;Assia Stepanian","doi":"10.1016/j.ejogrb.2026.114949","DOIUrl":"10.1016/j.ejogrb.2026.114949","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of mesenchymal stem cell (MSC)-based therapies in improving endometrial thickness and reproductive outcomes in women with refractory thin endometrium or Asherman’s syndrome.</div></div><div><h3>Methods</h3><div>Following PRISMA 2020 guidelines, a systematic search of PubMed, Cochrane Library, Embase, Scopus, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, and Google Scholar through June 2025 was performed. Eighteen clinical studies involving 323 patients were included. MSCs derived from umbilical cord, bone marrow, adipose tissue, endometrium, or menstrual blood were administered via intrauterine infusion, transmyometrial injection, or scaffold-assisted delivery. The primary outcome was change in endometrial thickness; secondary outcomes included clinical pregnancy rate, live birth rate, and miscarriage rate.</div></div><div><h3>Results</h3><div>Meta-analysis demonstrated a significant increase in endometrial thickness following MSC therapy compared to baseline or control (mean difference = 2.35 mm; 95 % CI, 1.97–2.74; p &lt; 0.00001). Subgroup analysis showed the largest gains in endometrial- and adipose-derived MSC groups. Randomized controlled trials confirmed higher clinical pregnancy (OR = 2.72; p = 0.002) and live birth rates (OR = 2.27; p = 0.01), with a reduced miscarriage rate (OR = 0.24; p = 0.004). No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>While MSC therapy appears to be safe, its efficacy must be confirmed by large-scale randomized trials before it can be presented to the public or recommended as an effective approach for endometrial regeneration.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114949"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening, diagnosing, and managing perinatal depression: Review of SIX national guidelines","authors":"James Bernard Hill ,&nbsp;Isabella Sullivan ,&nbsp;Katherine Lakey ,&nbsp;Kimberly Evans ,&nbsp;Edna Osei ,&nbsp;Suneet P. Chauhan","doi":"10.1016/j.ejogrb.2026.114977","DOIUrl":"10.1016/j.ejogrb.2026.114977","url":null,"abstract":"<div><div>Perinatal depression is a common and serious mental health condition affecting up to 20% of pregnant and postpartum individuals worldwide. It is characterized by persistent low mood, anhedonia, and functional impairment, with potential consequences for maternal well-being, obstetric outcomes, and infant development. Management is challenging for obstetricians, as treatment decisions must balance maternal mental health needs with fetal and neonatal safety, amid varying guideline recommendations and limited consensus on optimal screening and pharmacologic strategies. The American College of Obstetricians and Gynecologists, the National Institute for Health and Care Excellence, the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, the Scottish Intercollegiate Guidelines Network, the Centre of Perinatal Excellence and the Canadian Network for Mood and Anxiety Treatment have all released guidelines to address the risks, diagnosis and management of perinatal depression. We performed a descriptive review of these guidelines along with a literature search to address conflicting recommendations and highlight new evidence. The variations in the guidelines reflect the heterogeneity of literature and the challenges of diagnosis and managing perinatal depression.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114977"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern \"Abdominal electromyography may predict the response to tocolysis in preterm labor\". [Eur. J. Obstet. Gynecol. Reprod. Biol. 160/1 (2012) 18-21].","authors":"Mohamed A Kandil, Mehany M Abdel-Sattar, Sherif M Abdel-Salam, SaidA Saleh, Mohamed M Khalafallah","doi":"10.1016/j.ejogrb.2026.114970","DOIUrl":"10.1016/j.ejogrb.2026.114970","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"114970"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in predicting response to neoadjuvant chemotherapy in advanced high-grade serous ovarian cancer: a prospective study","authors":"Suday Halder ,&nbsp;Jyoti Meena ,&nbsp;Seema Singhal ,&nbsp;Rajesh Kumari ,&nbsp;Sachin Khurana ,&nbsp;Sandeep Mathur ,&nbsp;Archana Singh ,&nbsp;Sumit Kumar Das ,&nbsp;Neena Malhotra","doi":"10.1016/j.ejogrb.2025.114901","DOIUrl":"10.1016/j.ejogrb.2025.114901","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can predict pathological and clinical responses to neoadjuvant chemotherapy (NACT) in patients with advanced-stage high-grade serous ovarian carcinoma (HGSOC).</div></div><div><h3>Methods</h3><div>In this prospective cohort study, 80 patients with FIGO stage III–IV HGSOC received three cycles of platinum-based neoadjuvant chemotherapy. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were measured before and after the neoadjuvant treatment. Treatment response was evaluated using RECIST 1.1, chemotherapy response score (CRS), and the Completeness of cytoreduction score (CC score). The associations between these inflammatory markers and outcomes were analyzed using appropriate statistical tests.</div></div><div><h3>Results</h3><div>Following neoadjuvant chemotherapy, patients who achieved a good histopathological response (CRS 3) showed significantly lower baseline and post-NACT NLR and PLR values compared to those with CRS 1–2 (p &lt; 0.001). Baseline NLR &gt; 5.5 (Sensitivity: 94.7 %, Specificity: 86.9 %), PLR &gt; 177 (Sensitivity: 94.7 %, Specificity: 88.5 %) predicted poor histopathological response (CRS1).</div></div><div><h3>Conclusion</h3><div>Pre- and post-NACT NLR and PLR may serve as valuable, non-invasive biomarkers for predicting histopathologic response to chemotherapy in advanced serous ovarian carcinoma. Incorporating these inflammatory markers into preoperative assessment may improve patient stratification and surgical planning.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"318 ","pages":"Article 114901"},"PeriodicalIF":1.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}