Epigenomics最新文献_第3页

A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies. 连续结果的差异DNA甲基化分析方法的比较：对表观遗传学研究的影响。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-03-19 DOI: 10.1080/17501911.2026.2645006

Oladejo Ahmodu, Gaurav Bhatti, Adi L Tarca

{"title":"A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies.","authors":"Oladejo Ahmodu, Gaurav Bhatti, Adi L Tarca","doi":"10.1080/17501911.2026.2645006","DOIUrl":"10.1080/17501911.2026.2645006","url":null,"abstract":"Background: Univariate methods are widely employed in epigenome-wide association studies to identify CpGs associated with phenotypic traits. However, their performance has not been thoroughly evaluated.Methods: We compared commonly used methods- limma, Spearman's correlation (SC), and quantile regression (QR)- for analysis of methylation changes with gestational and individual age across multiple cohorts. The comparison was based on reproducibility, genomic location distribution, and predictive accuracy of CpGs identified as differentially methylated.Results: Limma identified more consistent gestational age-associated CpGs (n = 1,846) than SC (n = 1,409; p = 3.25e-15) and QR (n = 1,145; p < 2.2e-16). CpGs selected by limma and SC were more clustered within chromosomes than QR, as determined by nearest neighbor index analysis (p < 0.05). For gestational age prediction using top 100 features, random forest and elastic net yielded more accurate models (lower RMSE) for limma and SC compared to QR (all p < 0.05). With top 10,000 features, random forest again favored limma and SC over QR, while elastic net performed comparably across methods. Similar results were obtained for analysis of individual age.Conclusion: The findings of this study indicate that the choice of differential methylation analysis method impacts CpG-level reproducibility, within chromosome co-location, and predictive accuracy. Overall, limma offers a strong balance of reproducibility and predictive value.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"279-292"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor regarding "Epigenetic investigation into NR3C1 exon 1F and HSD11B2: associations with neurodevelopment and oral feeding skills in preterm infants". 致编辑关于“NR3C1外显子1F和HSD11B2的表观遗传学研究：与早产儿神经发育和口腔喂养技能的关系”的回复。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-03-27 DOI: 10.1080/17501911.2026.2652221

Thao Griffith

引用次数: 0

Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy. 靶向血脑屏障的表观遗传重塑：目前的药物治疗知识。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.1080/17501911.2026.2637419

Maya Akhoury, Nicole Vegara, Svetlana M Stamatovic, Richard F Keep, Anuska V Andjelkovic

{"title":"Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy.","authors":"Maya Akhoury, Nicole Vegara, Svetlana M Stamatovic, Richard F Keep, Anuska V Andjelkovic","doi":"10.1080/17501911.2026.2637419","DOIUrl":"10.1080/17501911.2026.2637419","url":null,"abstract":"The blood - brain barrier (BBB) is a dynamic regulator of brain homeostasis, and its dysfunction is a hallmark of many neurological and psychiatric disorders. Yet, in most conditions, the causal relationship between BBB injury and disease progression remains unclear, as shared systemic risk factors, such as inflammation, infection, oxidative stress, and genetic predisposition, produce highly variable patterns of barrier disruption. Epigenetic mechanisms, including DNA and RNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs, have emerged as key regulators of BBB integrity. Their dysregulation contributes to pathological BBB remodeling in disorders such as cerebrovascular and neurodegenerative diseases, promoting a decline in barrier function (structural and biochemical) and accelerating disease progression. Owing to their reversible nature, epigenetic modifications represent promising therapeutic targets, and their disease-stage-specific patterns offer potential as biomarkers for BBB injury and recovery. This review summarizes current knowledge on how epigenetic processes drive BBB dysfunction and highlights emerging epigenetic signatures with diagnostic and therapeutic relevance across neurological and psychiatric diseases.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"335-352"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung's disease. 外泌体传播的microRNA-323a-3p参与了巨结肠病的发生。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-03-29 DOI: 10.1080/17501911.2026.2647714

Haoran Shen, Chenglong Wang, Xiurui Lv, Zichuan Gao, Yuanxiang Qiu, Zhengke Zhi, Jie Tang, Chunxia Du, Ruyi Zhang, Hongxing Li, Weibing Tang

{"title":"Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung's disease.","authors":"Haoran Shen, Chenglong Wang, Xiurui Lv, Zichuan Gao, Yuanxiang Qiu, Zhengke Zhi, Jie Tang, Chunxia Du, Ruyi Zhang, Hongxing Li, Weibing Tang","doi":"10.1080/17501911.2026.2647714","DOIUrl":"10.1080/17501911.2026.2647714","url":null,"abstract":"Background: Hirschsprung's disease (HSCR) is caused by defective enteric neural crest cell (ENCC) migration. Exosome-transmitted microRNAs are implicated in HSCR pathogenesis, but mechanisms remain unclear.Methods: Plasma exosomes and colon tissues were collected from HSCR patients and controls. We assessed the effects of exosomal miR-323a-3p on the proliferation and migration of immortalized ENCC-derived neural cell line (iENC) in vitro using CCK-8, EdU and Transwell assays, and its impact on ENCC migration in vivo using a zebrafish model.Results: Exosomal miR-323a-3p was significantly upregulated in the plasma of HSCR and exhibited prospective diagnostic relevance (AUC = 0.7269, p = 0.0043). Exosomal miR-323a-3p was taken up by iENCs and suppressed their proliferation and migration. TET2 was identified as a potential miR-323a-3p target. TET2 was downregulated in HSCR aganglionic tissues, and its knockdown inhibited iENC proliferation and migration. In the zebrafish model, exosomal miR-323a-3p impaired distal ENCC colonization.Conclusion: Exosomal miR-323a-3p is upregulated in HSCR and associated with impaired ENCC-derived cell function, potentially via TET2. These findings suggest exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung's disease and exhibit promising potential as a prospective diagnostic biomarker.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"293-302"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From research to clinical practice: DNA methylation signatures as diagnostic tools for Alzheimer's disease. 从研究到临床实践：DNA甲基化特征作为阿尔茨海默病的诊断工具。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-02-23 DOI: 10.1080/17501911.2026.2635932

Nobuyoshi Shimoda

{"title":"From research to clinical practice: DNA methylation signatures as diagnostic tools for Alzheimer's disease.","authors":"Nobuyoshi Shimoda","doi":"10.1080/17501911.2026.2635932","DOIUrl":"10.1080/17501911.2026.2635932","url":null,"abstract":"Based on their ability to analyze methylation differences genome-wide in a large number of samples at a reasonable cost and time, microarrays were rapidly adopted by Alzheimer's disease (AD) researchers to isolate CpG sites with methylation levels that were changed in the blood of AD patients. However, concerns gradually arose about the reproducibility of these methylation markers. I attribute the cause to the lack of confirmation of methylation changes detected by DNA methylation arrays. Only by simply plotting an individual's methylation distribution can some false methylation differences be avoided. Furthermore, we may need to set a realistic, minimum threshold for methylation changes for clinical purposes. The prospect of using DNA methylation as a diagnostic marker for AD may be compromised by the increasing number of irreproducible markers. Therefore, establishing minimum guidelines for the search and presentation of AD-associated methylation markers is necessary when publishing. Some empirically useful guidelines are outlined in this Perspective, and applications for diagnosing AD using reliable methylation markers are also presented. One of the most desired applications of methylation markers will be to identify individuals whose cognitive abilities decline before memory problems appear, a task that has not yet been accomplished with protein markers or imaging.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"303-310"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Epigenetic investigation into NR3C1 exon 1F and HSD11B2: associations with neurodevelopment and oral feeding skills in preterm infants". 对“NR3C1外显子1F和HSD11B2的表观遗传学研究：与早产儿神经发育和口腔喂养技能的关系”的评论

IF 2.6 4区医学

Epigenomics Pub Date : 2026-03-01 Epub Date: 2026-03-29 DOI: 10.1080/17501911.2026.2652274

Ayman M Mustafa

引用次数: 0

Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health. 父亲孕前锻炼与精子表观遗传机制：对后代健康的系统综述。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1080/17501911.2026.2620390

Guilherme da Silva Rodrigues, Andressa Crystine da Silva Sobrinho, Ana Paulo Pinto, Rachel Lione, Ivo Vieira de Sousa Neto, Adelino Sanchez Ramos da Silva

{"title":"Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health.","authors":"Guilherme da Silva Rodrigues, Andressa Crystine da Silva Sobrinho, Ana Paulo Pinto, Rachel Lione, Ivo Vieira de Sousa Neto, Adelino Sanchez Ramos da Silva","doi":"10.1080/17501911.2026.2620390","DOIUrl":"10.1080/17501911.2026.2620390","url":null,"abstract":"Introduction: Paternal biology before conception can influence offspring health beyond DNA sequence inheritance. Paternal exercise is a modifiable exposure that can remodel the male germline epigenome through DNA methylation, histone modifications, and small non-coding RNAs, potentially affecting offspring development and metabolism.Methods: This systematic review searched PubMed/MEDLINE, Scopus, Web of Science, LILACS, and EMBASE without year restrictions. Experimental animal studies were eligible if sires exercised before conception and reported sperm or offspring epigenetic outcomes alongside molecular or phenotypic measures. Study selection followed predefined criteria.Results: Of 14,409 records identified, 7836 duplicates were removed, and 6573 records were screened. Six studies met the inclusion criteria. Across treadmill and voluntary running paradigms, paternal exercise was associated with reduced offspring hippocampal DNA methylation, altered sperm small RNAs, decreased sperm H3K9 dimethylation, lower placental inflammatory mRNA expression, and improved offspring outcomes, including spatial learning, anxiety-like behavior, endurance, mitochondrial respiration, glucose tolerance, and insulin sensitivity.Conclusion: Paternal exercise before conception remodels the male germline and is associated with beneficial metabolic, mitochondrial, and behavioral adaptations in offspring through epigenetic mechanisms, supporting its potential relevance for intergenerational health.Protocol registration: https://www.crd.york.ac.uk/prospero identifier is CRD420251141579.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"217-229"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data. EpiSmokEr2：使用Illumina EPIC甲基化数据推断吸烟状态的鲁棒表观遗传分类器。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-02-01 Epub Date: 2026-02-17 DOI: 10.1080/17501911.2026.2630841

Tianyu Zhu, Teodóra Faragó, Sailalitha Bollepalli, Aino Heikkinen, Mikaela Hukkanen, Olli Raitakari, Terho Lehtimäki, Tellervo Korhonen, Jaakko Kaprio, Fang Fang, Kaitlyn G Lawrence, Dale P Sandler, Mari Roberts Spildrejorde, Kristina Gervin, Yanyu Pan, Ricardo Costeira, Jordana T Bell, Miina Ollikainen

{"title":"EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data.","authors":"Tianyu Zhu, Teodóra Faragó, Sailalitha Bollepalli, Aino Heikkinen, Mikaela Hukkanen, Olli Raitakari, Terho Lehtimäki, Tellervo Korhonen, Jaakko Kaprio, Fang Fang, Kaitlyn G Lawrence, Dale P Sandler, Mari Roberts Spildrejorde, Kristina Gervin, Yanyu Pan, Ricardo Costeira, Jordana T Bell, Miina Ollikainen","doi":"10.1080/17501911.2026.2630841","DOIUrl":"10.1080/17501911.2026.2630841","url":null,"abstract":"Aim: Tobacco smoking induces persistent DNA methylation (DNAm) changes in blood that can serve as long-term biomarkers for smoking exposure. We aimed to develop and validate a DNAm classifier of smoking status using Illumina EPIC array data.Methods: We built Epigenetic Smoking status Estimator2 (EpiSmokEr2), a Least Absolute Shrinkage and Selection Operator (LASSO) regression-based DNAm classifier using 511 CpGs from Illumina Infinium MethylationEPIC array (EPIC) data. The model was trained on 1343 samples from the Young Finns Study cohort and validated across six independent datasets from four cohorts and two array platforms (EPIC and EPICv2).Results: EpiSmokEr2 achieved an average sensitivity of 0.87 and specificity of 0.86 in distinguishing current from never smokers. Predicted smoking status correlated strongly with established DNAm smoking scores and GrimAge, indicating its ability to capture biologically relevant smoking effects. Simulation analysis showed EpiSmokEr2 was robust for up to 10% missing CpGs.Conclusion: EpiSmokEr2 provides a reliable DNAm-based estimator of smoking status. It is available as an open-source R package on GitHub, facilitating broad use in epidemiological and clinical research.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"205-215"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the epigenetic consequences of ART in male infertility: what risks to embryo and offspring health? 评估男性不育症抗逆转录病毒治疗的表观遗传后果：对胚胎和后代健康有什么风险？

IF 2.6 4区医学

Epigenomics Pub Date : 2026-02-01 Epub Date: 2026-03-02 DOI: 10.1080/17501911.2026.2633977

Jorge Hallak, Thiago Afonso Teixeira, João Pedro M Gismondi, Eduardo Zinoni S Pato, Robert John Aitken, Fabio Firmbach Pasqualotto, Sandro C Esteves

{"title":"Assessing the epigenetic consequences of ART in male infertility: what risks to embryo and offspring health?","authors":"Jorge Hallak, Thiago Afonso Teixeira, João Pedro M Gismondi, Eduardo Zinoni S Pato, Robert John Aitken, Fabio Firmbach Pasqualotto, Sandro C Esteves","doi":"10.1080/17501911.2026.2633977","DOIUrl":"10.1080/17501911.2026.2633977","url":null,"abstract":"Male infertility affects approximately 7 to 8% of men worldwide and is influenced by both genetic and epigenetic factors. Epigenetic mechanisms - including DNA methylation, histone modifications, and non-coding RNAs - are essential for spermatogenesis, sperm function, and early embryonic development. Disruptions in these processes can impair fertility and embryo viability. Assisted reproductive technologies (ART), particularly intracytoplasmic sperm injection (ICSI), have enabled conception in previously untreatable cases; however, by bypassing natural selection barriers, they may facilitate the transmission of epigenetic abnormalities. This narrative review summarizes recent clinical and experimental evidence on sperm epigenetics, emphasizing paternal health, sperm epigenetic signatures, and ART-associated developmental risks. During spermatogenesis, extensive epigenetic remodeling occurs, including protamine-histone exchange, selective histone retention, and RNA packaging, all critical for embryogenesis. Conditions such as varicocele, obesity, advanced paternal age, toxin exposure, and malignancy have been linked to abnormal DNA methylation, altered chromatin structure, and dysregulated small RNAs. Seminal extracellular vesicles also mediate environmental influences on implantation and immune modulation. Because ART coincides with windows of epigenetic vulnerability, laboratory procedures - including sperm selection, cryopreservation, and embryo culture - may contribute to imprinting disturbances. Understanding these mechanisms is essential to optimize reproductive safety while preserving ART efficacy.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"255-267"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated epigenetic aging and shorter DNA methylation-based telomere length in sarcopenic obesity: an exploratory pilot study. 加速表观遗传衰老和缩短基于DNA甲基化的端粒长度在肌肉减少型肥胖：一项探索性试点研究。

IF 2.6 4区医学

Epigenomics Pub Date : 2026-02-01 Epub Date: 2026-01-24 DOI: 10.1080/17501911.2026.2617179

Ana Claudia Rossini Venturini, Caroline Fogagnolo, Gabriela Ueta Ortiz, Guilherme da Silva Rodrigues, Arthur Polveiro da Silva, Natália Yumi Noronha, Gabriela Ferreira Abud, Bianca Monteiro Silva, Gabriela Geraldo Benzoni, Marcela Augusta de Souza Pinhel, Lígia Moriguchi Watanabe, Chanachai Sae-Lee, Sofia Germano Travieso, Marcela Coffacci de Lima Viliod, Carla Barbosa Nonino, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas

{"title":"Accelerated epigenetic aging and shorter DNA methylation-based telomere length in sarcopenic obesity: an exploratory pilot study.","authors":"Ana Claudia Rossini Venturini, Caroline Fogagnolo, Gabriela Ueta Ortiz, Guilherme da Silva Rodrigues, Arthur Polveiro da Silva, Natália Yumi Noronha, Gabriela Ferreira Abud, Bianca Monteiro Silva, Gabriela Geraldo Benzoni, Marcela Augusta de Souza Pinhel, Lígia Moriguchi Watanabe, Chanachai Sae-Lee, Sofia Germano Travieso, Marcela Coffacci de Lima Viliod, Carla Barbosa Nonino, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas","doi":"10.1080/17501911.2026.2617179","DOIUrl":"10.1080/17501911.2026.2617179","url":null,"abstract":"Background: Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and low muscle mass/function, has been linked to adverse outcomes. Epigenetic alterations are central hallmarks of aging. Evaluating how obesity, sarcopenia, and SO are related to epigenetic aging biomarkers may provide insights into cellular aging and disease risk.Methods: In this cross-sectional study, 30 older women were classified into the control, obesity, sarcopenia, and SO groups and underwent anthropometry measurements, body composition analysis, and handgrip strength. Blood DNA methylation (DNAm) biomarkers were used to estimate eight epigenetic clocks (Horvath, Hannum, DNAmTL, PhenoAge, GrimAge, GrimAge2, Zhang, and FitAge) and to calculate intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA). Associations were tested with Bayesian linear and quantile regressions, adjusted for age and HOMA-IR.Results: SO was associated with higher EEAA, DNAmFitAge, and Hannum clock estimates, and shorter DNAmTL in both models. Obesity showed positive associations with these clocks in adjusted models and higher quantiles.Conclusions: SO is associated with accelerated aging and shorter DNAmTL. Obesity contributes to biological aging, whereas sarcopenia without obesity does not. These findings suggest that excess adiposity combined with low muscle mass may worsen age-related decline, although the small sample size should be considered.","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"169-183"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0