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The potential utility of cord blood DNA methylation in pediatric clinical practice. 脐带血 DNA 甲基化在儿科临床实践中的潜在用途。
IF 3 4区 医学
Epigenomics Pub Date : 2024-11-01 Epub Date: 2024-11-12 DOI: 10.1080/17501911.2024.2408217
Stephanie W Waldrop, Wei Perng, Iain R Konigsberg, Sarah J Borengasser
{"title":"The potential utility of cord blood DNA methylation in pediatric clinical practice.","authors":"Stephanie W Waldrop, Wei Perng, Iain R Konigsberg, Sarah J Borengasser","doi":"10.1080/17501911.2024.2408217","DOIUrl":"10.1080/17501911.2024.2408217","url":null,"abstract":"<p><p>Our understanding of the origins of noncommunicable diseases has evolved over the years with greater consideration given to the lasting influence exposures and experiences during the preconceptional and prenatal periods can have. Research highlights the associations of parental exposures (e.g., diet, obesity, gestational diabetes, lipid profile, toxic exposures and microbiome) with the infant/fetal methylome and suggest associations with infant, child and/or adolescent chronic health outcomes. Thus, epigenetics and specifically cord blood DNA methylation may have utility as biomarkers for disease risk identification and stratification in pediatrics. However, for cord blood DNA methylation analyses to be leveraged as biomarkers of disease risk in pediatric clinical practice, the results must be replicable, validated and clinically meaningful. Challenges and opportunities to this prospect are herein discussed.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"1365-1372"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric microbiome composition accompanied with the Helicobacter pylori related DNA methylation anomaly. 胃微生物组的组成与幽门螺旋杆菌相关的 DNA 甲基化异常有关。
IF 3 4区 医学
Epigenomics Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.1080/17501911.2024.2418803
Takuya Shijimaya, Tomomitsu Tahara, Tsubasa Shimogama, Jumpei Yamazaki, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Makoto Naganuma
{"title":"Gastric microbiome composition accompanied with the <i>Helicobacter pylori</i> related DNA methylation anomaly.","authors":"Takuya Shijimaya, Tomomitsu Tahara, Tsubasa Shimogama, Jumpei Yamazaki, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Makoto Naganuma","doi":"10.1080/17501911.2024.2418803","DOIUrl":"10.1080/17501911.2024.2418803","url":null,"abstract":"<p><p><b>Aim:</b> DNA methylation is associated with gastric cancer and <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection, while increasing evidence indicated involvement of other microbes reside in gastric mucosa during gastric tumorigenesis. We investigated bacterial communities in the gastric mucosa accompanied with <i>H. pylori</i> related methylation anomaly.<b>Materials & methods:</b> Gastric mucosa samples from antrum were obtained from 182 cancer-free patients. Bacterial communities were evaluated using 16S rRNA sequencing. The result was correlated with <i>H. pylori</i> related promoter CpG island (CGI) methylation of five genes (<i>IGF2, SLC16A12, SOX11, P2RX7 and MYOD1</i>), LINE1 hypomethylation and telomere length.<b>Results & conclusion:</b> We showed correlation between lower bacterial alpha diversity and higher CGI methylation. Multivariate analysis demonstrated older age (t = 3.46, <i>p</i> = 0.0007), <i>H. pylori</i> infection (t = 9.99, <i>p</i> < 0.0001) and lower bacterial alfa diversity (Shannon index: t = -2.34, <i>p</i> = 0.02) were significantly associated with CGI hypermethylation. In genus or family levels, increased abundance of <i>Helicobacter</i> was associated with hyper CGI methylation with strongest correlation, while decreased abundance of four bacteria (<i>Intrasporangiaceae family, Macellibacteroides</i>, <i>Peptostreptococcus</i> and <i>Dietziaceae family</i>) was also associated with hyper CGI methylation. Our findings suggest the potential correlation between CGI methylation induction and lower bacterial alpha diversity in the gastric mucosa accompanied by <i>H. pylori</i> infection.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"1329-1336"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential methylation patterns from clusters associated with glucose metabolism: evidence from a Shanghai twin study. 与葡萄糖代谢相关的群组的差异甲基化模式：来自上海双生子研究的证据。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-02-27 DOI: 10.2217/epi-2023-0449
Jingyuan Feng, Zhenni Zhu, Rongfei Zhou, Hongwei Liu, Zihan Hu, Fei Wu, Huiting Wang, Junhong Yue, Tong Zhou, Li Yang, Fan Wu
{"title":"Differential methylation patterns from clusters associated with glucose metabolism: evidence from a Shanghai twin study.","authors":"Jingyuan Feng, Zhenni Zhu, Rongfei Zhou, Hongwei Liu, Zihan Hu, Fei Wu, Huiting Wang, Junhong Yue, Tong Zhou, Li Yang, Fan Wu","doi":"10.2217/epi-2023-0449","DOIUrl":"10.2217/epi-2023-0449","url":null,"abstract":"<p><p><b>Aim:</b> To assess the associations between genome-wide DNA methylation (DNAm) and glucose metabolism among a Chinese population, in particular the multisite correlation. <b>Materials & methods:</b> Epigenome-wide associations with fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) were analyzed among 100 Shanghai monozygotic (MZ) twin pairs using the Infinium HumanMethylationEPIC v2.0 BeadChip. We conducted a Pearson's correlation test, hierarchical cluster and pairwise analysis to examine the differential methylation patterns from clusters. <b>Results:</b> Cg01358804 (<i>TXNIP</i>) was identified as the most significant site associated with FPG and HbA1c. Two clusters with hypermethylated and hypomethylated patterns were observed for both FPG and HbA1c. <b>Conclusion:</b> Differential methylation patterns from clusters may provide new clues for epigenetic changes and biological mechanisms in glucose metabolism.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"445-459"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy. hsa_circ_0087100/hsa-miR-6743-5p 通过调节 STAT1 影响糖尿病视网膜病变中 Th1 细胞的分化。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-02-27 DOI: 10.2217/epi-2023-0359
Shuai He, Dongwei Lai, Chenggong Ma, Chunren Meng, Chunyang Cai, Qian Chen, Chufeng Gu, Qinghua Qiu
{"title":"<i>hsa_circ_0087100/hsa-miR-6743-5p</i> affects Th1 cell differentiation by regulating <i>STAT1</i> in diabetic retinopathy.","authors":"Shuai He, Dongwei Lai, Chenggong Ma, Chunren Meng, Chunyang Cai, Qian Chen, Chufeng Gu, Qinghua Qiu","doi":"10.2217/epi-2023-0359","DOIUrl":"10.2217/epi-2023-0359","url":null,"abstract":"<p><p><b>Objective:</b> To elucidate the role of the competitive endogenous RNA (ceRNA) network in immune infiltration of diabetic retinopathy (DR). <b>Methods:</b> We obtained differentially expressed (DE) circRNAs, miRNAs and mRNAs from the Gene Expression Omnibus database. Then, we identified immune infiltration by CIBERSORT and single-sample gene set enrichment analysis and discovered co-expression genes by weighted gene co-expression network analysis. Furthermore, <i>STAT1</i>-mediated Th1 differentiation was determined in DR cell models, DR patients and DR mouse models. <b>Results:</b> <i>hsa_circ_0087100/hsa-miR-6743-5p/STAT1</i> was involved in immune infiltration of Th1 cells. Aberrant expression of the ceRNA network and <i>STAT1</i>-mediated Th1 differentiation was thus verified <i>in vitro</i> and <i>in vivo</i>. <b>Conclusion:</b> <i>hsa_circ_0087100/hsa-miR-6743-5p/STAT1</i> may affect Th1 cell differentiation in DR.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"427-444"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA methylation marker identification and poly-methylation risk score in prediction of healthspan termination. DNA 甲基化标记鉴定和多甲基化风险评分在预测健康寿命终止中的作用。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-03-14 DOI: 10.2217/epi-2023-0343
Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai
{"title":"DNA methylation marker identification and poly-methylation risk score in prediction of healthspan termination.","authors":"Meiqi Yang, Mei Wang, Xiaoyu Zhao, Feifei Xu, Shuang Liang, Yifan Wang, Nanxi Wang, Muhammed Lamin Sambou, Yue Jiang, Juncheng Dai","doi":"10.2217/epi-2023-0343","DOIUrl":"10.2217/epi-2023-0343","url":null,"abstract":"<p><p><b>Aim:</b> To elucidate the epigenetic consequences of DNA methylation in healthspan termination (HST), considering the current limited understanding. <b>Materials & methods:</b> Genetically predicted DNA methylation models were established (n = 2478). These models were applied to genome-wide association study data on HST. Then, a poly-methylation risk score (PMRS) was established in 241,008 individuals from the UK Biobank. <b>Results:</b> Of the 63,046 CpGs from the prediction models, 13 novel CpGs were associated with HST. Furthermore, people with high PMRSs showed higher HST risk (hazard ratio: 1.18; 95% CI: 1.13-1.25). <b>Conclusion:</b> The study indicates that DNA methylation may influence HST by regulating the expression of genes (e.g., <i>PRMT6</i>, <i>CTSK</i>). PMRSs have a promising application in discriminating subpopulations to facilitate early prevention.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"461-472"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on the functional role of miRNA clusters in cervical cancer. 全面回顾 miRNA 簇在宫颈癌中的功能作用。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.2217/epi-2023-0244
Srinath Sriharikrishnaa, Femi E John, Medha Bairy, Sachin Shetty, Padmanaban S Suresh, Shama P Kabekkodu
{"title":"A comprehensive review on the functional role of miRNA clusters in cervical cancer.","authors":"Srinath Sriharikrishnaa, Femi E John, Medha Bairy, Sachin Shetty, Padmanaban S Suresh, Shama P Kabekkodu","doi":"10.2217/epi-2023-0244","DOIUrl":"10.2217/epi-2023-0244","url":null,"abstract":"<p><p>Cervical cancer (CC) poses a significant health threat in women globally. MicroRNA clusters (MCs), comprising multiple miRNA-encoding genes, are pivotal in gene regulation. Various factors, including circular RNA and DNA methylation, govern MC expression. Dysregulated MC expression correlates strongly with CC development via promoting the acquisition of cancer hallmarks. Certain MCs show promise for diagnosis, prognosis and therapy selection due to their distinct expression patterns in normal, premalignant and tumor tissues. This review explains the regulation and biological functions of MCs and highlights the clinical relevance of abnormal MC expression in CC.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"493-511"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics and the neurodegenerative process. 表观遗传学和神经退行性病变过程。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.2217/epi-2023-0416
Bartosz Słowikowski, Wojciech Owecki, Jan Jeske, Michał Jezierski, Michał Draguła, Ulyana Goutor, Paweł P Jagodziński, Wojciech Kozubski, Jolanta Dorszewska
{"title":"Epigenetics and the neurodegenerative process.","authors":"Bartosz Słowikowski, Wojciech Owecki, Jan Jeske, Michał Jezierski, Michał Draguła, Ulyana Goutor, Paweł P Jagodziński, Wojciech Kozubski, Jolanta Dorszewska","doi":"10.2217/epi-2023-0416","DOIUrl":"10.2217/epi-2023-0416","url":null,"abstract":"<p><p>Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity and emotional state are epigenetic factors. Environmental markers are responsible for epigenetic modifications. The effect of epigenetic changes is increased inflammation of the nervous system and neuronal damage. In recent years, it has been shown that epigenetic changes may cause an increased risk of neurological disorders but, currently, the relationship between epigenetic modifications and neurodegeneration remains unclear. This review summarizes current knowledge about neurological disorders caused by epigenetic changes in diseases such as Alzheimer's disease, Parkinson's disease, stroke and epilepsy. Advances in epigenetic techniques may be key to understanding the epigenetics of central changes in neurological diseases.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"473-491"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases. 缩小差距：R 环介导的基因组不稳定性及其对神经系统疾病的影响。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-03-26 DOI: 10.2217/epi-2023-0379
Katherine R Westover, Peng Jin, Bing Yao
{"title":"Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases.","authors":"Katherine R Westover, Peng Jin, Bing Yao","doi":"10.2217/epi-2023-0379","DOIUrl":"10.2217/epi-2023-0379","url":null,"abstract":"<p><p>R-loops, intricate three-stranded structures formed by RNA-DNA hybrids and an exposed non-template DNA strand, are fundamental to various biological phenomena. They carry out essential and contrasting functions within cellular mechanisms, underlining their critical role in maintaining cellular homeostasis. The specific cellular context that dictates R-loop formation determines their function, particularly emphasizing the necessity for their meticulous genomic regulation. Notably, the aberrant formation or misregulation of R-loops is implicated in numerous neurological disorders. This review focuses on the complex interactions between R-loops and double-strand DNA breaks, exploring how R-loop dysregulation potentially contributes to the pathogenesis of various brain disorders, which could provide novel insights into the molecular mechanisms underpinning neurological disease progression and identify potential therapeutic targets by highlighting these aspects.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response. 针对 AR 和 EZH2 的联合疗法可抑制阉割耐药前列腺癌，增强抗肿瘤 T 细胞反应。
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-03-26 DOI: 10.2217/epi-2023-0374
Irene Fischetti, Laura Botti, Roberta Sulsenti, Valeria Cancila, Claudia Enriquez, Renata Ferri, Marco Bregni, Filippo Crivelli, Claudio Tripodo, Mario P Colombo, Elena Jachetti
{"title":"Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response.","authors":"Irene Fischetti, Laura Botti, Roberta Sulsenti, Valeria Cancila, Claudia Enriquez, Renata Ferri, Marco Bregni, Filippo Crivelli, Claudio Tripodo, Mario P Colombo, Elena Jachetti","doi":"10.2217/epi-2023-0374","DOIUrl":"10.2217/epi-2023-0374","url":null,"abstract":"<p><p><b>Aim:</b> Castration-resistant prostate cancer (CRPC) eventually becomes resistant to androgen receptor pathway inhibitors like enzalutamide. Immunotherapy also fails in CRPC. We propose a new approach to simultaneously revert enzalutamide resistance and rewire anti-tumor immunity. <b>Methods:</b> We investigated <i>in vitro</i> and in subcutaneous and spontaneous mouse models the effects of combining enzalutamide and GSK-126, a drug inhibiting the epigenetic modulator EZH2. <b>Results:</b> Enzalutamide and GSK-126 synergized to reduce CRPC growth, also restraining tumor neuroendocrine differentiation. The anti-tumor activity was lost in immunodeficient mice. Indeed, the combination treatment awoke cytotoxic activity and IFN-γ production of tumor-specific CD8<sup>+</sup> T lymphocytes. <b>Conclusion:</b> These results promote the combination of enzalutamide and GSK-126 in CRPC, also offering new avenues for immunotherapy in prostate cancer.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma. 多种组蛋白修饰对肺腺癌关键铁变态相关基因的核心调节作用
IF 3.8 4区 医学
Epigenomics Pub Date : 2024-03-21 DOI: 10.2217/epi-2023-0403
Ye-Chen Qi, Hui Bai, Si-Le Hu, Shu-Juan Li, Qian-Zhong Li
{"title":"Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma.","authors":"Ye-Chen Qi, Hui Bai, Si-Le Hu, Shu-Juan Li, Qian-Zhong Li","doi":"10.2217/epi-2023-0403","DOIUrl":"10.2217/epi-2023-0403","url":null,"abstract":"<p><p><b>Aim:</b> The present study was designed to investigate the coregulatory effects of multiple histone modifications (HMs) on gene expression in lung adenocarcinoma (LUAD). <b>Materials & methods:</b> Ten histones for LUAD were analyzed using ChIP-seq and RNA-seq data. An innovative computational method is proposed to quantify the coregulatory effects of multiple HMs on gene expression to identify strong coregulatory genes and regions. This method was applied to explore the coregulatory mechanisms of key ferroptosis-related genes in LUAD. <b>Results:</b> Nine strong coregulatory regions were identified for six ferroptosis-related genes with diverse coregulatory patterns (<i>CA9</i>, <i>PGD</i>, <i>CDKN2A</i>, <i>PML</i>, <i>OTUB1</i> and <i>NFE2L2</i>). <b>Conclusion:</b> This quantitative method could be used to identify important HM coregulatory genes and regions that may be epigenetic regulatory targets in cancers.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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