美国中年人的关系压力和表观遗传年龄加速研究。

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-09-30 DOI:10.1080/17501911.2025.2568301

Mariana Rodrigues, Jemar R Bather, Adolfo G Cuevas

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引用次数: 0

摘要

背景：长期的人际关系压力与加速的生物衰老有关，但关于哪些关系压力领域可能在中年期间最重要的问题仍然存在。研究设计和方法：线性回归模型量化了来自美国中年研究的1310名中年成年人（平均年龄= 51岁，SD = 13）的特定领域关系压力源（婚姻风险、伴侣压力、家庭压力、友谊压力）与下一代表观遗传时钟（DunedinPACE和GrimAge2）之间的横向关联。结果：控制社会人口统计学和健康行为，我们发现友谊压力与加速衰老有独特的关联（grimag2: 0.03 SD增加，95% CI: 0.01, 0.05, p = 0.003; DunedinPACE: 0.05 SD增加，95% CI: 0.01, 0.09, p = 0.030）。在完全调整的模型中，未观察到其他应激源与GrimAge2或DunedinPACE有统计学意义的关联。结论：这些发现确定友谊紧张是中年加速生物衰老的潜在特定风险因素。未来的研究应探讨将友谊质量与细胞衰老联系起来的行为和生理机制。

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Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.

Background: Chronic interpersonal stress has been linked to accelerated biological aging, but questions remain about which relationship stress domains may be most consequential during midlife.

Research design and methods: Linear regression models quantified the cross-sectional associations between domain-specific relationship stressors (marital risk, partner strain, family strain, friendship strain) and next-generation epigenetic clocks (DunedinPACE and GrimAge2) in 1,310 midlife adults from the Midlife in the United States study (mean age = 51, SD = 13).

Results: Controlling for sociodemographic and health behaviors, we found that friendship strain was uniquely associated with accelerated aging (GrimAge2: 0.03 SD increase, 95% CI: 0.01, 0.05, p = 0.003; DunedinPACE: 0.05 SD increase, 95% CI: 0.01, 0.09, p = 0.030). No statistically significant associations were observed for the other stressors with GrimAge2 or DunedinPACE in fully adjusted models.

Conclusions: These findings identify friendship strain as a potential specific risk factor for accelerated biological aging in midlife. Future research should investigate behavioral and physiological mechanisms linking friendship quality to cellular aging.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.