European Journal of Cancer Care最新文献

{"title":"“There is No Alternative.” Treatment Decision-Making in Lung Cancer Patients with Limited Prognosis: Results of a Qualitative Interview Study","authors":"Laura Unsöld,&nbsp;Nicole Deis,&nbsp;Anja Siegle,&nbsp;Michael Thomas,&nbsp;Matthias Villalobos","doi":"10.1155/2024/8889981","DOIUrl":"https://doi.org/10.1155/2024/8889981","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. Decision-making in advanced cancer with a limited prognosis is particularly challenging: constantly evolving therapeutic algorithms with new treatment options that show marginal benefits have to be balanced with end-of-life decision-making. But existing decision support tools for advanced cancer patients are rare, not routinely used in clinical practice and do not sufficiently meet patients’ needs. Therefore, our project explores the experienced decision-making process in advanced lung cancer to derive recommendations for the use of shared decision-making in this context. <i>Methods</i>. 20 semistructured interviews with lung cancer patients, their relatives, and healthcare professionals were conducted. All data were transcribed verbatim and analyzed with a thematic content analysis. <i>Results</i>. The decision-making process of advanced cancer patients is mainly characterized by a lack of perceived options. Physicians do not adequately present palliative care as an alternative or additional support for these patients. Being confronted with limited options that only include active cancer treatment patients tend to choose a more paternalistic decision model leaving the treatment decision to their physicians and accepting aggressive treatments uncritically. <i>Conclusion</i>. A paternalistic decision-making model in advanced cancer may neglect individual wishes, values, and preferences of patients and promote a feeling of powerlessness. Empowerment of these patients is needed with context-specific SDM tools and trainings of professionals to avoid overtreatment and facilitate the timely integration of palliative care. This trial is registered in DRKS00023674.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8889981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Factors That Influence the Spiritual Care Needs of Patients with Advanced Cancer","authors":"Min Zhou,&nbsp;Yijia Zhang,&nbsp;Wenjie Yang,&nbsp;Harry H. X. Wang,&nbsp;Sang Min Park,&nbsp;Sitong Liu,&nbsp;Heng Piao","doi":"10.1155/2024/5809074","DOIUrl":"https://doi.org/10.1155/2024/5809074","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. To explore the factors influencing the spiritual care needs of patients with advanced cancer. <i>Method</i>. A sample of 321 patients with advanced cancer, who have been treated in the Affiliated Cancer Hospital of Zhengzhou University from December 2022 to February 2023, was recruited. Clinical data of patients participating in this study were collected via a customized questionnaire. The validated Chinese version of the spiritual care needs scale was used to evaluate patients’ spiritual care needs. Statistical analyses included the unpaired <i>t</i>-test, analysis of variance, and multiple linear regression. <i>Result</i>. The average score of spiritual care needs was 33.81 ± 7.76 points. Multiple regression analysis revealed that age (<i>t</i> = 4.24 and <i>P</i> &lt; 0.01), occupation (<i>t</i> = 2.971 and <i>P</i> &lt; 0.01), and alcohol consumption (<i>t</i> = 3.477 and <i>P</i> &lt; 0.01) significantly influenced spiritual care needs. Patients with age, occupation, and alcohol consumption negatively impact spiritual needs, that is, the older the age, the smaller the spiritual needs. Individuals who engaged in business units, individual businesses, or had a drinking habit had lower spiritual needs. <i>Conclusion</i>. The scores of spiritual care needs in patients with advanced cancer were influenced by factors such as age, occupation, and alcohol consumption.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5809074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142130425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Literacy and Healthcare Seeking with Lung Cancer Symptoms among Individuals with Different Smoking Statuses: A Population-Based Study","authors":"Lisa Maria Sele Sætre,&nbsp;Kirubakaran Balasubramaniam,&nbsp;Anna Aaby,&nbsp;Sanne Rasmussen,&nbsp;Jens Søndergaard,&nbsp;Dorte Ejg Jarbøl","doi":"10.1155/2024/7919967","DOIUrl":"https://doi.org/10.1155/2024/7919967","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. To estimate proportions of contacts to the general practitioner (GP) among people with specific and nonspecific lung cancer symptoms, respectively, in the Danish general population and to analyse the associations between health literacy and these contacts based on smoking status. <i>Methods</i>. A total of 67,280 randomly selected individuals aged ≥40 years were invited to a survey concerning symptoms and healthcare seeking. This study included lung cancer symptoms, GP contacts, smoking status, four aspects of health literacy, and socioeconomics. Descriptive statistics and multivariable logistic regression models were applied. <i>Results</i>. Of 22,055 respondents, 23% reported at least one specific lung cancer symptom, while 47% reported at least one nonspecific symptom. GP contacts ranged from 30% (tiredness) to 60% (shortness of breath). Individuals who currently smoke had lower odds of GP contacts. The health literacy aspect “Feeling understood and supported” increased the likelihood of GP contact, while “Having sufficient information” decreased the likelihood. Smoking status did not modify these associations. <i>Conclusion</i>. Efforts targeting individuals at risk of postponing healthcare seeking with lung cancer symptoms are needed. This study highlights aspects of health literacy that may be addressed in interventions increasing both individuals and community-based health literacy responsiveness and enhanced chances of timely healthcare seeking.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7919967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Validation of a Novel Prognostic T-Cell Exhaustion-Related ceRNA Network in Lung Adenocarcinoma","authors":"Hua Ye,&nbsp;Wenwen Yu,&nbsp;Xiaoqiong Bao,&nbsp;Yangyang Ni,&nbsp;Weilong Zhou,&nbsp;Yunlei Li,&nbsp;Xiangxiang Chen,&nbsp;Jifa Li,&nbsp;Long Zheng","doi":"10.1155/2024/8660434","DOIUrl":"https://doi.org/10.1155/2024/8660434","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. T cell exhaustion (TEX) is a state of T cells that is characterized by poor function of effectors and increased expression of inhibitory signals. However, the heterogeneity and prognostic values of TEX in lung adenocarcinoma (LUAD) remain not fully understood. <i>Methods</i>. Based on the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) transcriptomic profiles, we screened differentially expressed lncRNAs, miRNAs, and mRNAs and identified differentially expressed TEXs. Univariate cox and LASSO regression analyses were performed to construct TEX-related prognostic signature and risk score and validated their expression using real-time PCR assay. We then investigated the potential mechanism, immune landscape, and antitumor therapy response in LUAD. <i>Results</i>. A total of 315 DE-lncRNAs, 161 DE-miRNAs, and 2589 DEGs were screened, and then 80 DE-TEXGs were identified in LUAD. Based on univariate cox and LASSO regression analyses, CCNA2 and SLC2A1 were identified as TEX-related prognostic signatures, and the risk score subsequently was calculated. LUAD patients were divided into high- and low-risk groups, and high-risk groups were involved in poor survival status, immunosuppression, and more sensitive to anti-CTLA4 therapy. Finally, a TEX-related ceRNA network was constructed and validated based on DE-lncRNAs, DE-miRNAs, and TEX-related prognostic signatures. <i>Conclusion</i>. We constructed the TEX-related prognostic signature and its relevant ceRNA network and discovered the molecular mechanism and prognostic values of TEX in LUAD.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8660434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Gene Expression Data with GWAS Highlights the Causal Gene CCDC25 as a Biomarker for a Favorable Prognosis in Colorectal Cancer","authors":"Guowei Zhang,&nbsp;Yuling Ma,&nbsp;Jianfeng Shao,&nbsp;Caiping Ke,&nbsp;Chunhua Li,&nbsp;Yaping Dong","doi":"10.1155/2024/3735659","DOIUrl":"https://doi.org/10.1155/2024/3735659","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Coiled-coil domain containing 25 (CCDC25) is a receptor for neutrophil extracellular trap (NET) DNA and is involved in various cancers, including CRC. This study aimed to investigate the regulatory role of CCDC25 in CRC using GWAS data, eQTL, transcriptomic profiles, and clinical information of CRC patients. <i>Methods</i>. From open-source databases, GWAS summary data, eQTL expression profiles, and transcriptomic profiles, as well as clinical information were collected for CRC patients. Mendelian randomization (MR) was used to investigate the causal relationship between CCDC25 and CRC risk. The expression of CCDC25 and its associated differentially expressed genes (DEGs) were identified. We explored the relationship between CCDC25 expression and survival, biological functions, immune cell infiltration, immune checkpoint expression, and response to immunotherapy. <i>Results</i>. High CCDC25 expression reduces the risk of CRC. CCDC25 is downregulated in various cancers, particularly in CRC tumor tissues compared to normal tissues. Metabolic pathways are enriched in groups with high CCDC25 expression, while cancer-related pathways are enriched in groups with low CCDC25 expression. High CCDC25 expression is also associated with increased infiltration of resting memory CD4+ T cells, elevated levels of most immune checkpoints, and an enhanced response to anti-PD1 therapy. In addition, 95 DEGs were identified between high-CCDC25 and low-CCDC25 groups, and eight genes (FDFT1, ASAH1, ADAM9, CXCL14, SERPINA1, NAT1, EREG, and GSR) were identified as prognostic genes. <i>Conclusion</i>. CDC25 might serve as a candidate diagnostic and prognostic marker for CRC patients<i>.</i></p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/3735659","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory Potential of Poly (ADP-Ribose) Polymerase 1 (PARP1) in BRCA-Mutated Tumors","authors":"Valens Munyembaraga,&nbsp;Delphine Cyuzuzo,&nbsp;Tran Nhat Phong Dao,&nbsp;Babatunji Emmanuel Oyinloye,&nbsp;Sunday Amos Onikanni,&nbsp;Hen-Hong Chang","doi":"10.1155/2024/8897255","DOIUrl":"https://doi.org/10.1155/2024/8897255","url":null,"abstract":"<div>\u0000 <p>Poly (ADP-ribose) polymerase 1 is a versatile enzyme that is deeply involved in diverse cellular processes. It exerts influence on pivotal activities such as DNA repair, transcriptional regulation, and cell death. PARP1 is crucial due to its susceptibility to posttranslational modifications, each of which has distinct roles in shaping its functionality and interactions with other proteins. Among these modifications, the addition of ADP-ribose polymerase 1 and the addition of an acetyl group to lysine residues enhance PARP1 engagement in DNA repair, while ubiquitination and cleavage are involved in the degradation of PARP1. PARP1 modification has been exploited in cancer treatment, particularly in the context of breast and ovarian cancers marked by BRCA1 and BRCA2 mutations. However, resistance to PARP1 inhibitors and selective posttranslational modifications, which confer cellular functions remain elusive. The present review endeavors to detail the extent of PARP1 modifications, shedding light on their profound implications at the cellular remains a challenge, which often drives treatment failure. The effectiveness of PARP1 inhibitors relies on specific level. This trial is registered with NCT04550104, NCT06120491, NCT05367440, NCT05797168, NCT04644068, NCT05573724, NCT05489211, NCT05938270, and NCT02264678.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8897255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal Values, Wishes, and Goals of Patients with Advanced Lung Cancer: A Qualitative Study","authors":"Mara König,&nbsp;Anja Siegle,&nbsp;Laura Unsöld,&nbsp;Jan Ole Ludwig,&nbsp;Nicole Deis,&nbsp;Michael Thomas,&nbsp;Regina Poß-Doering,&nbsp;Matthias Villalobos","doi":"10.1155/2024/9987322","DOIUrl":"https://doi.org/10.1155/2024/9987322","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. Oncology and palliative care guidelines for patients with incurable cancer recommend supporting patients at the end of life (EOL) by considering their personal values, wishes, and goals to facilitate decision making in advance care planning and patient-centered care. It is unclear, though, how to successfully address and integrate personal values in clinical practice. The aim of this study was to explore values, wishes, and goals from the perspective of patients with advanced lung cancer. <i>Methods</i>. Semistructured interviews were conducted with patients with advanced lung cancer and transcribed verbatim. The data were analysed using a structured content analysis. After identification of main categories, values were identified using Schwartz’s Theory of Basic Human Values as a theoretical framework. <i>Results</i>. Identified main categories were “the individual in medical care,” “living now,” and “coming to terms.” Values in the dimensions “conservation” and “openness to change” were described concerning patient-physician interaction, therapy goals, preparedness for EOL, and life goals. “Self-transcendence” values mainly related to caring for the burden on relatives. In general, patients showed reluctance in expressing information about personal values when communicating with physicians. <i>Conclusion</i>. Patients with advanced lung cancer engage in various ways to determine how they want and can influence their life and medical care. Different values and the associated wishes and goals play a crucial role in this context and should be taken into account by healthcare providers. The reluctance to express personal information in medical encounters underscores the need for a proactive attitude in physicians and improved interprofessional collaboration. The study was registered in the German register for clinical trials (DRKS00026993).</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9987322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiemetic Efficacy and Safety of Palonosetron on Days 1 and 5 with Aprepitant and Dexamethasone during Bleomycin, Etoposide, and Cisplatin Chemotherapy in Patients with Germ Cell Tumor: A Prospective Study","authors":"Fumimasa Fukuta,&nbsp;Hiroshi Kitamura,&nbsp;Hiroshi Hotta,&nbsp;Naoki Itoh,&nbsp;Manabu Okada,&nbsp;Tetsuya Shindo,&nbsp;Yuki Kyoda,&nbsp;Kohei Hashimoto,&nbsp;Ko Kobayashi,&nbsp;Toshiaki Tanaka,&nbsp;Naoya Masumori","doi":"10.1155/2024/8838889","DOIUrl":"https://doi.org/10.1155/2024/8838889","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. BEP (bleomycin, etoposide, and cisplatin) chemotherapy is a standard regimen for germ cell tumors (GCTs); however, their high emetogenicity is problematic. The control of chemotherapy-induced nausea and vomiting (CINV) is crucial to complete the treatment. We conducted this study to explore the efficacy and safety of antiemetic therapy with dexamethasone and aprepitant for 5 days in combination with palonosetron 0.75 mg on days 1 and 5 in BEP. <i>Methods</i>. This open-label single-arm study was prospectively conducted in 4 hospitals. Chemotherapy-naïve men with GCT who were scheduled to receive the BEP regimen were eligible. The primary endpoint was the complete response (CR) rate of CINV. <i>Results</i>. A total of 19 patients were enrolled. Overall, 16 (84.2%) patients experienced some nausea, whereas only 4 (21.1%) patients had grade 1 emetic events. Overall CR of CINV was achieved in 9 (47.4%) patients. Although 14 (73.7%) patients experienced 22 adverse events after palonosetron administration, severe adverse events (grade 3 or more) attributable to it did not occur. <i>Conclusion</i>. The results suggest that aprepitant, palonosetron, and dexamethasone antiemetic therapy for patients with GCT receiving BEP is safe, whereas the efficacy of additional palonosetron administration on day 5 for prevention of delayed CINV remains unclear. This trial is registered with UMIN000008110.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8838889","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Outpatients’ Self-Reported Pain Relief, Analgesic Adherence, and Constipation during Follow-Up Support: A Prospective, Longitudinal Study","authors":"Hong Yang,&nbsp;Xiaoxiao Ma,&nbsp;Shiyi Zhang,&nbsp;Jinxing Shao,&nbsp;Xin Li,&nbsp;Lihua Hao,&nbsp;Hong Zhang,&nbsp;Fanxiu Heng,&nbsp;Yuhan Lu","doi":"10.1155/2024/5579783","DOIUrl":"https://doi.org/10.1155/2024/5579783","url":null,"abstract":"<div>\u0000 <p><i>Aims and Objectives</i>. This prospective study describes the pain relief, analgesic adherence, and constipation experienced by cancer outpatients with pain during the first three cycles of follow-up support based on an information system. <i>Methods</i>. Outpatients with cancer pain who received at least three cycles of follow-up support between 1 July 2020 and 31 March 2022 at our cancer centre were enrolled in this prospective, longitudinal study. Three cycles of follow-up support were provided by trained nurses over the telephone. Pain relief, analgesic adherence, and constipation were reported by the patients and recorded in the information system by trained nurses during the telephone follow-up. <i>Results</i>. A total of 386 cancer patients were enrolled in the study. Pain relief and analgesic adherence improved significantly during the three follow-up cycles after they received support (<i>P</i> &lt; 0.001). The rate of pain relief and analgesic adherence improved at the second cycle compared to the first cycle, but the rate decreased at the third cycle compared to the second cycle. Some patients who had no problems at the first follow-up cycle experienced new problems during the second and third follow-up cycles. There was no significant difference in the incidence of constipation between follow-up cycles (<i>P</i> = 0.078). <i>Conclusions</i>. Cancer outpatients with pain reported increased pain relief and analgesic adherence during follow-up support. Compared to rates at the first and third cycles, pain relief and analgesic adherence were best at the second cycle after follow-up support according to the information system. <i>Relevance to Clinical Practice</i>. Changes in pain intensity, analgesic adherence, and constipation were noted over time, which highlights the need for continuous follow-up to achieve prolonged pain relief in cancer patients after discharge from the hospital.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5579783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141583972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Incompatibilities between Areas of Life in Cancer Survivors: Development and Psychometric Evaluation of the INCOMPAT-CS Instrument","authors":"Kati Hiltrop,&nbsp;Clara Breidenbach,&nbsp;Marie Degenhardt,&nbsp;Paula Heidkamp,&nbsp;Lina Heier,&nbsp;Christoph Kowalski,&nbsp;Sophie Schellack,&nbsp;Johannes Soff,&nbsp;Nicole Ernstmann","doi":"10.1155/2024/8863478","DOIUrl":"https://doi.org/10.1155/2024/8863478","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. Due to various long-term consequences of the disease, cancer survivors (CS) can experience incompatibilities between areas of life (work, family, household, leisure time, and disease) that can be associated with reduced satisfaction with these areas of life. To be able to assess such incompatibilities quantitatively, a six-item instrument (INCOMPAT-CS) was developed and psychometrically evaluated. <i>Methods</i>. Based on relevant theories, a multidisciplinary team developed the items of the INCOMPAT-CS. Descriptive analyses, exploratory and confirmatory factor analyses, as well as validity and reliability assessments were conducted using survey data from <i>n</i> = 293 CS collected as part of the CARES study. Incompatibilities between areas of life were measured with the newly developed INCOMPAT-CS instrument. <i>Results</i>. A one component solution with satisfactory model fit (normed <i>χ</i>² = 1.90, RMSEA = 0.06, CFI = 0.99, and TLI = 0.97) was identified in exploratory and confirmatory factor analyses. The INCOMPAT-CS demonstrated acceptable internal consistency (Cronbach’s <i>α</i> = 0.790) and high test-retest reliability <i>ρ</i> = 0.569 (<i>p</i> &lt; 0.001). Convergent validity could be demonstrated (CR = 0.858 and AVE = 0.506). Hypothesis-consistent correlations with role and social functioning measures further indicate convergent validity. <i>Conclusions</i>. The INCOMPAT-CS is useful to assess incompatibilities among areas of life in CS quantitatively. Moreover, it helps to reveal the areas negatively affected due to incompatibilities. This short instrument can be useful in aftercare or psychosocial support interventions to detect incompatibilities and work towards reducing them as a consequence to increase CS’ wellbeing.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2024 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8863478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}