European Journal of Cancer Care最新文献

{"title":"Exploring the Care Needs of Women With Breast Cancer and the Time From Diagnosis to Treatment: A Qualitative Study","authors":"Mahboubeh Sadat Yousefi,&nbsp;Mahnaz Ilkhani,&nbsp;Mohammad Esmaeil Akbari,&nbsp;Sima Zohari Anboohi,&nbsp;Fatemeh Heshmati Nabavi","doi":"10.1155/ecc/8896043","DOIUrl":"https://doi.org/10.1155/ecc/8896043","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Breast cancer is the most common type of cancer in Iranian women. Early needs assessment of patients at the time of diagnosis and across the phases of cancer treatment is essential to provide timely and appropriate supportive care. Therefore, the present study aims to explore the care needs of breast cancer patients from the time of diagnosis to treatment completion.</p>\u0000 <p><b>Methods:</b> This qualitative research was conducted as a conventional content analysis, based on the Graneheim and Lundman approach. Eighteen participants, consisting of breast cancer patients, family members, oncology nurses, and oncologists, were selected using a purposive sampling method with maximum diversity. Data were collected using in-depth semistructured interviews and entered into the MAXQDA 2020 software for analysis. Lincoln and Guba’s criteria for credibility, transferability, dependability, and confirmability were used to validate the research findings.</p>\u0000 <p><b>Results:</b> The needs of women with breast cancer in the diagnosis and treatment phases were categorized into two and seven categories and five and 18 subcategories, respectively. The themes that emerged relating to women’s needs at the time of diagnosis included psychoemotional and informational needs. The needs of women in the treatment phase were categorized into the following themes: informational, practical, psychoemotional, physical, spiritual, communication, and sexual needs.</p>\u0000 <p><b>Conclusions:</b> This study provides valuable insights into optimal and patient-oriented supportive care, accounting for the numerous needs of patients with breast cancer. Healthcare providers should provide supportive care according to patients’ needs and preferences, which will lead to the correct use of resources and cost reduction as well as improving the quality of life of cancer patients. Supportive care needs are culture-dependent. Thus, cultural issues must be considered when developing an effective supportive care program.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8896043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Patient-Reported Outcomes in Patients With Osteosarcoma: A Systematic Review","authors":"Ana Sebio,&nbsp;Claire Berger,&nbsp;Marie-Dominique Tabone,&nbsp;Natalia Fernandez,&nbsp;Faustine Tardy,&nbsp;Martha Grootenhuis,&nbsp;Emanuela Palmerini,&nbsp;Nathalie Gaspar,&nbsp;Michiel van de Sande,&nbsp;Lianne M. Haveman,&nbsp;The FOSTER Consortium","doi":"10.1155/ecc/5802523","DOIUrl":"https://doi.org/10.1155/ecc/5802523","url":null,"abstract":"<div>\u0000 <p>Patients diagnosed with osteosarcoma undergo intensive multimodality treatment that can lead to long-term adverse effects, significantly impacting various aspects of daily living. To objectively assess the Health-Related Quality of Life (HR-QoL) in pediatric and adult populations, several Patient-Reported Outcome Measurements (PROMs) are available. However, these questionnaires often exhibit substantial variability in the domains and items they encompass, frequently failing to address aspects that are particularly important after osteosarcoma treatment. A systematic review was conducted to identify the most frequently used questionnaires concerning QoL in pediatric and adult patients with osteosarcoma and to examine the diverse domains and subdomains of QoL assessed by these questionnaires to identify gaps in their coverage, to recommend suitable instruments for an upcoming European trial within the Fighting Osteosarcoma Through European Research (FOSTER) Consortium. English-language literature published since 1980 in PubMed was reviewed. One hundred twenty-eight articles were initially screened for eligibility. Sixty-three original articles were included in the qualitative synthesis. An overview from review articles was given. Selected studies displayed substantial heterogeneity in terms of their objectives, target populations, age ranges, follow-up time, and number of patients included. None of the questionnaires covered all age groups and addressed all important aspects following osteosarcoma treatment. To comprehensively address as many relevant aspects as possible, a combination of questionnaires is suggested. For the adult population, it is recommended to use the EORTC-QLQ-C30 questionnaire together with the Body Image Scale (BIS), while for pediatric patients, the PedsQl-generic and PedsQl-cancer-specific questionnaires and BIS (&gt; 16 years) are suggested. The use of Patient-Reported Outcome Measurement Information Systems (PROMIS) can provide a comprehensive assessment of symptoms such as anxiety, pain, and fatigue. The development of new bone sarcoma-specific, pediatric and adult self-reported questionnaires, or the validation and translation of existing bone sarcoma-specific questionnaires, along with the utilization of new digital possibilities, holds great value for upcoming trials.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5802523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perceptions of Patients, Carers and Clinicians Relating to SACT Decision-Making in Older People With Cancer: Qualitative Findings From the Electronic Frailty Index (eFI) in Cancer Study","authors":"Katie Sutton,&nbsp;Jo Armes,&nbsp;Simon S. Skene,&nbsp;Janine Mansi,&nbsp;Agnieszka Michael","doi":"10.1155/ecc/4399728","DOIUrl":"https://doi.org/10.1155/ecc/4399728","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To explore the perceptions and experiences of patients, carers and clinicians relating to treatment decision-making in older people with cancer, and to investigate the acceptability of the eFI as a tool to influence decisions about SACT.</p>\u0000 <p><b>Methods:</b> Qualitative interviews were conducted with 28 participants (12 clinicians, 10 patients and 6 carers) at an NHS cancer day unit in South East England. Patients were &gt; 60 years and had received at least one cycle of SACT. Data were analysed using framework analysis.</p>\u0000 <p><b>Results:</b> Two themes were identified. Theme one highlighted that the assessment of frailty is a variable and complex task. However, an individualised assessment incorporating a balance between quality of life and the potential benefit of treatment is fundamentally important. Theme two identified that eFI is an acceptable addition to SACT decision-making which must be discussed with the patient and considered within the context of each individual situation.</p>\u0000 <p><b>Conclusion:</b> The eFI is acceptable for use in assessing the frailty of older people with cancer prior to starting SACT. In-depth, individualised assessment prior to SACT is important in this population, but it is not always realistic. Incorporating the eFI into SACT decision-making offers the potential to address this challenge.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/4399728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Needs in Parental Cancer: A Qualitative Analysis of Contextual Factors From the Perspective of Healthy Parents—Results From the Family-SCOUT Study","authors":"Johanna Weiß,&nbsp;Nicole Ernstmann,&nbsp;Christian Heuser,&nbsp;Hannah Nakata,&nbsp;Evamarie Brock-Midding,&nbsp;Rebecca Horbach-Bremen,&nbsp;Tim H. Brümmendorf,&nbsp;Manuela Brüne,&nbsp;Marc Dohmen,&nbsp;Barbara Drueke,&nbsp;Franziska Geiser,&nbsp;Steffen Holsteg,&nbsp;Andrea Icks,&nbsp;André Karger,&nbsp;Jens Panse,&nbsp;Andrea Petermann-Meyer,&nbsp;Anja Viehmann,&nbsp;Lina Heier","doi":"10.1155/ecc/7707431","DOIUrl":"https://doi.org/10.1155/ecc/7707431","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Parental cancer affects the whole family and can have negative impact on family as a system as well as on single family members. This multicentre, prospective, interventional and non-randomized family-SCOUT study aimed to implement a comprehensive psychosocial intervention to provide support for the family during and after the disease. The purpose of this study is to analyse the contextual factors that impact the subjective perceived effectiveness of family-scout support for families affected by parental cancer from the healthy parents’ perspective.</p>\u0000 <p><b>Methods:</b> Semi-structured interviews with the healthy parent as a surrogate of family-SCOUT families from the intervention group were conducted. All interviews were audio-recorded, transcribed and analysed using template analysis.</p>\u0000 <p><b>Results:</b> Within two years, 23 interviews were conducted. Four themes were identified, highlighting contextual factors that indicate successful support for families: Ability to meet the support needs of families; cancer as a family disease—burdens in the context of the family system; coping strategies—how the individual family members deal with the situation and communication within the family.</p>\u0000 <p><b>Conclusion:</b> Family-scouts can provide beneficial support to families affected by parental cancer, but individual time of the families, communication and stress factors need to be taken into consideration.</p>\u0000 <p><b>Trial Registration:</b>​ Familien-SCOUT: NCT04186923</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7707431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns of Women With Breast Cancer During Their Therapy in Iran: A Qualitative Investigation","authors":"Nasrin Sadidi,&nbsp;Armita Shahesmaeili,&nbsp;Parvin Mangolian Shahrbabaki,&nbsp;Mohammad Ali Zakeri,&nbsp;Behjat Kalantari Khandani,&nbsp;Aliakbar Haghdoost","doi":"10.1155/ecc/3157813","DOIUrl":"https://doi.org/10.1155/ecc/3157813","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> Women with breast cancer (BC) may have dreadful experiences mainly because of the severity of their disease, the complications of treatments, and its psychological burden. In this study, we explored the concerns of BC cases in Iran. Therefore, this study aimed to investigate the problems of BC patients from the beginning of treatment and its continuation in Kerman city.</p>\u0000 <p><b>Methods:</b> This qualitative descriptive–explorative study was conducted using a conventional content analysis approach to investigate the concerns of women with BC during their therapy in Iran. A total of 30 women with BC were included in the study through purposive sampling. Data were collected through in-depth, semi-structured interviews. The study process lasted from November 2019 to December 2022.</p>\u0000 <p><b>Results:</b> Three hundred and twenty codes, 1 main category, 3 categories, and 16 subcategories were extracted. Based on the participants’ experiences, women with BC face various concerns during their treatment: (1) physical and psychological problems, (2) family and social problems, and (3) organizational problems.</p>\u0000 <p><b>Conclusion:</b> This study shows that most of the concerns of BC are related to psycho-emotional problems, easy access to medicine and treatment costs, and other economic problems. This clearly shows the urgent need of these patients for regular counseling and follow-up and more support in the field of financing. Addressing concerns before treatment, particularly among women who are considered a vulnerable group in society, can assist researchers and specialists in planning counseling and necessary follow-ups to reduce these patients’ anxiety and support their rehabilitation after treatment. Attention to the necessary psychological and social support for these patients may also help improve their adaptation.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3157813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the SUMOylation Gene Signature in Colon Cancer by Transcriptome and Mendelian Randomization Integration","authors":"Xiaobin Zhang,&nbsp;Qingshui Yang,&nbsp;Zongyu Liang,&nbsp;Zhu Li,&nbsp;Chunlei Lu","doi":"10.1155/ecc/8659536","DOIUrl":"https://doi.org/10.1155/ecc/8659536","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> SUMOylation is a posttranslational protein modification, which is involved in tumorigenesis, aggression, metastasis, drug resistance, and prognosis, while the molecular characteristics and prognostic values of the SUMOylation remain unclear.</p>\u0000 <p><b>Methods:</b> The transcriptomic data were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), and summary-level data of genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL) from European ancestry were collected. The SUMOylation patterns of CRC patients, tumor microenvironment (TME) immune cell infiltrating characteristics, biological function therapeutic responses, and prognostic signatures were identified. Mendelian randomization (MR) analysis explored the causality between prognostic signatures and CRC.</p>\u0000 <p><b>Results:</b> Three SUMOylation-related clusters were classified, and Cluster 2 showed the worst survival status, most populations of infiltrated immune cells, responses to anti-CTLA-4 and anti-PD-1 therapies, and sensitivity to chemotherapy. Nine SUMOylation-related signatures (NDC1, PPARGC1A, CDKN2A, UHRF2, NUP54, PIAS3, H4C4, CHD3, and SUMO2) were selected and validated as prognostic signatures. A predictive nomogram was constructed and validated. Finally, NUP54 was positive, but PPARGC1A was negatively associated with the risk of CRC.</p>\u0000 <p><b>Conclusion:</b> This study first comprehensively explored the molecular characteristics and prognostic values of SUMOylation and identified the possible biomarkers for treatment in CRC.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8659536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZDHHC9 as a Potential Biomarker for Prognostic Evaluation and Diagnostic Identification in BRCA, CESC, HNSC, and KIRP Tumors","authors":"Qunlong Liu,&nbsp;Wenxia Li,&nbsp;Ming Xie,&nbsp;Ming Yang,&nbsp;Mei Xu,&nbsp;Lei Yang,&nbsp;Mengru Sun,&nbsp;Yanna Peng,&nbsp;Li Gao","doi":"10.1155/ecc/2641908","DOIUrl":"https://doi.org/10.1155/ecc/2641908","url":null,"abstract":"<div>\u0000 <p>An expanding corpus of evidence suggests that zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) may represent a promising biomarker in various malignancies. Noteworthy is the fact that ZDHHC9 has been discovered to be significantly upregulated in specific varieties of human gastrointestinal cancers. Nevertheless, the precise role it plays in tumor prognostic evaluation and diagnostic identification remains ambiguous. In this study, we commenced with a thorough investigation of ZDHHC9 expression by leveraging the extensive and comprehensive TCGA database. This resource offers a wealth of valuable information and data samples, which enabled a more comprehensive and thorough analysis. The expression levels of ZDHHC9 in BRCA, CESC, HNSC, and KIRP were thoroughly investigated, revealing a significant elevation compared to normal tissues. This significant escalation was observed to be intimately linked with an adverse prognosis. A comprehensive analysis of the data revealed that the increased expression of ZDHHC9 in these particular cancer types was associated with poorer outcomes for patients. The extensive study examining various cancer types has yielded significant insights regarding the function of ZDHHC9, as well as its potential implications for prognosis and therapeutic strategies. Functional predictions indicate that immune or metabolic disorders, as well as the activation of carcinogenic signaling pathways due to abnormal expression of ZDHHC9, may significantly contribute to tumor progression and poor prognosis in patients. This further corroborates the influence of ZDHHC9 on the migration and invasion capabilities of CESC cell lines. ZDHHC9 is a key target for therapeutic and diagnostic use in BRCA, CESC, HNSC, and KIRP tumors, contributing significantly to the understanding of molecular tumor treatments.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/2641908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors for Central Venous Access Device Complications in Pediatric Patients With Cancer: A Scoping Review","authors":"Jenna L. Nunn,&nbsp;Mari D. Takashima,&nbsp;Erin M. Wray-Jones,&nbsp;Trisha A. Soosay Raj,&nbsp;Diane M. Hanna,&nbsp;Amanda J. Ullman","doi":"10.1155/ecc/9956694","DOIUrl":"https://doi.org/10.1155/ecc/9956694","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> To systematically review the risk factors for central venous access device (CVAD)–associated complications in pediatric patients with cancer.</p>\u0000 <p><b>Methods:</b> A scoping review with systematic search criteria was conducted using PubMed, Embase, and CINAHL databases from 2012 to 2022. Cohort studies and the control arm of randomized controlled trials, which reported CVAD-associated complications in pediatric patients aged 0–18 years, were included.</p>\u0000 <p><b>Results:</b> 381 studies were identified in initial screening, with 25 studies included in the review. Device-related factors were commonly reported as risk factors for central line–associated blood stream infection, CVAD-associated venous thromboembolism (VTE), and device failure. Tunneled central venous catheter (TCVC), multilumen devices, and larger diameter lumens were risk factors for CLABSI. TCVCs were a risk factor for device failure. PICCs were a risk factor for CVAD-associated VTE. Provider and patient-related risk factors were rarely reported. There is significant inconsistency in the quality of reporting of vascular access data.</p>\u0000 <p><b>Conclusion:</b> External devices are associated with an increased risk of CVAD-associated complications. There is a limited good quality prospective evidence on risk factors for CVAD-associated complications in this cohort. Further research is needed to understand drivers of these complications, inform preventative strategies, and guide device-selection decisions. Improved research quality through adherence to benchmarking reporting standards for vascular access data is also needed.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9956694","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Psychological Distress of Cancer and Hemodialysis Caregivers: A Comparative Cross-Sectional Study in Lebanon","authors":"Youssef El Toum,&nbsp;Chris Boulos,&nbsp;Tina Haddad,&nbsp;Tarek Costa,&nbsp;Elissa El Toum,&nbsp;Anthony Al Aaraj,&nbsp;Myriam Zarzour,&nbsp;Dania Chelala,&nbsp;Hiba Azar,&nbsp;Serge Finianos,&nbsp;Fady Elkarak,&nbsp;Marwan Ghosn,&nbsp;Georges Chahine,&nbsp;Rami Bou Khalil,&nbsp;Hampig Raphael Kourie,&nbsp;Joseph Kattan,&nbsp;Anthony Kassab","doi":"10.1155/ecc/6372523","DOIUrl":"https://doi.org/10.1155/ecc/6372523","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Chronic illnesses, such as cancer and end-stage kidney disease (ESKD), impose significant emotional and physical burdens not only on patients but also on their caregivers. Caregivers play a vital role in providing care, often facing psychological distress, including anxiety and depression, while their quality of life (QoL) may deteriorate. This study aims to compare anxiety, depression, and QoL among caregivers of cancer and ESKD patients in Lebanon.</p>\u0000 <p><b>Methods:</b> A cross-sectional study was conducted with 134 caregivers, including 71 cancer caregivers and 63 hemodialysis caregivers, at the Hôtel Dieu de France University Hospital in Beirut. Participants completed the Hospital Anxiety and Depression Scale (HADS) and the World Health Organization QoL (WHOQoL–BREF) Scale.</p>\u0000 <p><b>Results:</b> Caregivers of hemodialysis patients reported significantly lower QoL scores compared to cancer caregivers (<i>p</i> = 0.0006). Anxiety was prevalent in both groups, with no significant difference in anxiety or depression levels between the two groups. However, caregivers’ educational level (<i>p</i> = 0.01), anxiety scores (<i>p</i> = 0.006), and the patient’s comorbidity count (<i>p</i> = 0.007) significantly predicted QoL. Caregivers with higher education and fewer anxiety symptoms reported better QoL.</p>\u0000 <p><b>Conclusion:</b> Caregivers of ESKD patients experience poorer QoL than cancer caregivers, though both groups suffer from high anxiety and depression. To address these disparities, we emphasize the need for universal healthcare coverage, targeted support programs, and routine caregiver well-being assessments.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6372523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Physical Exercise Intervention, Delivered Through In-Person or Home-Based Programs, in Patients Living With Cancer and Bone Metastases: A Single-Arm, Feasibility Study","authors":"Anita Borsati,&nbsp;Christian Ciurnelli,&nbsp;Lorenzo Belluomini,&nbsp;Linda Toniolo,&nbsp;Ilaria Trestini,&nbsp;Daniela Tregnago,&nbsp;Marco Sposito,&nbsp;Jessica Insolda,&nbsp;Francesca Zacchi,&nbsp;Elena Fiorio,&nbsp;Francesco Bertoldo,&nbsp;Federico Schena,&nbsp;Michele Milella,&nbsp;Sara Pilotto,&nbsp;Alice Avancini","doi":"10.1155/ecc/3520570","DOIUrl":"https://doi.org/10.1155/ecc/3520570","url":null,"abstract":"<div>\u0000 <p>Evidence of the feasibility of physical exercise for patients with bone metastases is still scarce. This study assessed the feasibility of in-person or home-based exercise programs and explored their efficacy in patients with bone lesions. Twenty-one patients with bone metastases were invited to participate in an exercise intervention consisting of 12 weeks of <i>in-person</i> or home-based aerobic and resistance training twice a week. The primary study endpoint was the feasibility of the program, including recruitment, completion, attendance, adherence, tolerance rates, and safety. Secondary outcomes were physical fitness and patient-reported parameters. To analyze data descriptive statistics, Student’s <i>t</i> test and Wilcoxon signed-rank test were applied. The recruitment rate was 84%, and only one patient withdrew (5%). The median program attendance was 93%, and adherence was 85%, with the home-based program showing a higher adherence rate compared to the <i>in-person</i> delivery. Tolerability was 98%, and 13 mild (Grade 1 or 2) adverse events were registered. At postintervention, an increase in functional capacity was observed, while no significant changes in muscle strength, flexibility, or anthropometric parameters were detected. Enhancements in quality of life domains, including physical, role, and emotional functioning, as well as reductions in fatigue and appetite loss, were also reported. Our exercise intervention, whether delivered in person or through a home-based program, was highly feasible and safe.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04226508</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3520570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}