European Journal of Cancer Care最新文献

{"title":"Identifying Risk Factors for Central Venous Access Device Complications in Pediatric Patients With Cancer: A Scoping Review","authors":"Jenna L. Nunn,&nbsp;Mari D. Takashima,&nbsp;Erin M. Wray-Jones,&nbsp;Trisha A. Soosay Raj,&nbsp;Diane M. Hanna,&nbsp;Amanda J. Ullman","doi":"10.1155/ecc/9956694","DOIUrl":"https://doi.org/10.1155/ecc/9956694","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> To systematically review the risk factors for central venous access device (CVAD)–associated complications in pediatric patients with cancer.</p>\u0000 <p><b>Methods:</b> A scoping review with systematic search criteria was conducted using PubMed, Embase, and CINAHL databases from 2012 to 2022. Cohort studies and the control arm of randomized controlled trials, which reported CVAD-associated complications in pediatric patients aged 0–18 years, were included.</p>\u0000 <p><b>Results:</b> 381 studies were identified in initial screening, with 25 studies included in the review. Device-related factors were commonly reported as risk factors for central line–associated blood stream infection, CVAD-associated venous thromboembolism (VTE), and device failure. Tunneled central venous catheter (TCVC), multilumen devices, and larger diameter lumens were risk factors for CLABSI. TCVCs were a risk factor for device failure. PICCs were a risk factor for CVAD-associated VTE. Provider and patient-related risk factors were rarely reported. There is significant inconsistency in the quality of reporting of vascular access data.</p>\u0000 <p><b>Conclusion:</b> External devices are associated with an increased risk of CVAD-associated complications. There is a limited good quality prospective evidence on risk factors for CVAD-associated complications in this cohort. Further research is needed to understand drivers of these complications, inform preventative strategies, and guide device-selection decisions. Improved research quality through adherence to benchmarking reporting standards for vascular access data is also needed.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9956694","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Psychological Distress of Cancer and Hemodialysis Caregivers: A Comparative Cross-Sectional Study in Lebanon","authors":"Youssef El Toum,&nbsp;Chris Boulos,&nbsp;Tina Haddad,&nbsp;Tarek Costa,&nbsp;Elissa El Toum,&nbsp;Anthony Al Aaraj,&nbsp;Myriam Zarzour,&nbsp;Dania Chelala,&nbsp;Hiba Azar,&nbsp;Serge Finianos,&nbsp;Fady Elkarak,&nbsp;Marwan Ghosn,&nbsp;Georges Chahine,&nbsp;Rami Bou Khalil,&nbsp;Hampig Raphael Kourie,&nbsp;Joseph Kattan,&nbsp;Anthony Kassab","doi":"10.1155/ecc/6372523","DOIUrl":"https://doi.org/10.1155/ecc/6372523","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Chronic illnesses, such as cancer and end-stage kidney disease (ESKD), impose significant emotional and physical burdens not only on patients but also on their caregivers. Caregivers play a vital role in providing care, often facing psychological distress, including anxiety and depression, while their quality of life (QoL) may deteriorate. This study aims to compare anxiety, depression, and QoL among caregivers of cancer and ESKD patients in Lebanon.</p>\u0000 <p><b>Methods:</b> A cross-sectional study was conducted with 134 caregivers, including 71 cancer caregivers and 63 hemodialysis caregivers, at the Hôtel Dieu de France University Hospital in Beirut. Participants completed the Hospital Anxiety and Depression Scale (HADS) and the World Health Organization QoL (WHOQoL–BREF) Scale.</p>\u0000 <p><b>Results:</b> Caregivers of hemodialysis patients reported significantly lower QoL scores compared to cancer caregivers (<i>p</i> = 0.0006). Anxiety was prevalent in both groups, with no significant difference in anxiety or depression levels between the two groups. However, caregivers’ educational level (<i>p</i> = 0.01), anxiety scores (<i>p</i> = 0.006), and the patient’s comorbidity count (<i>p</i> = 0.007) significantly predicted QoL. Caregivers with higher education and fewer anxiety symptoms reported better QoL.</p>\u0000 <p><b>Conclusion:</b> Caregivers of ESKD patients experience poorer QoL than cancer caregivers, though both groups suffer from high anxiety and depression. To address these disparities, we emphasize the need for universal healthcare coverage, targeted support programs, and routine caregiver well-being assessments.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6372523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Physical Exercise Intervention, Delivered Through In-Person or Home-Based Programs, in Patients Living With Cancer and Bone Metastases: A Single-Arm, Feasibility Study","authors":"Anita Borsati,&nbsp;Christian Ciurnelli,&nbsp;Lorenzo Belluomini,&nbsp;Linda Toniolo,&nbsp;Ilaria Trestini,&nbsp;Daniela Tregnago,&nbsp;Marco Sposito,&nbsp;Jessica Insolda,&nbsp;Francesca Zacchi,&nbsp;Elena Fiorio,&nbsp;Francesco Bertoldo,&nbsp;Federico Schena,&nbsp;Michele Milella,&nbsp;Sara Pilotto,&nbsp;Alice Avancini","doi":"10.1155/ecc/3520570","DOIUrl":"https://doi.org/10.1155/ecc/3520570","url":null,"abstract":"<div>\u0000 <p>Evidence of the feasibility of physical exercise for patients with bone metastases is still scarce. This study assessed the feasibility of in-person or home-based exercise programs and explored their efficacy in patients with bone lesions. Twenty-one patients with bone metastases were invited to participate in an exercise intervention consisting of 12 weeks of <i>in-person</i> or home-based aerobic and resistance training twice a week. The primary study endpoint was the feasibility of the program, including recruitment, completion, attendance, adherence, tolerance rates, and safety. Secondary outcomes were physical fitness and patient-reported parameters. To analyze data descriptive statistics, Student’s <i>t</i> test and Wilcoxon signed-rank test were applied. The recruitment rate was 84%, and only one patient withdrew (5%). The median program attendance was 93%, and adherence was 85%, with the home-based program showing a higher adherence rate compared to the <i>in-person</i> delivery. Tolerability was 98%, and 13 mild (Grade 1 or 2) adverse events were registered. At postintervention, an increase in functional capacity was observed, while no significant changes in muscle strength, flexibility, or anthropometric parameters were detected. Enhancements in quality of life domains, including physical, role, and emotional functioning, as well as reductions in fatigue and appetite loss, were also reported. Our exercise intervention, whether delivered in person or through a home-based program, was highly feasible and safe.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04226508</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3520570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Upgrades From Biopsy Gleason Grades 1–3 to Radical Prostatectomy Gleason Grades 4–5 in Prostate Cancer Patients","authors":"Le Yu,&nbsp;Kewei Chen,&nbsp;Min Lu,&nbsp;Shaohui Deng,&nbsp;Ye Yan,&nbsp;Jianfei Ye,&nbsp;Fan Zhang,&nbsp;Shudong Zhang","doi":"10.1155/ecc/9940460","DOIUrl":"https://doi.org/10.1155/ecc/9940460","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Discordances of Gleason grade (GG) between biopsy and radical prostatectomy (RP) of prostate cancer (PCa) patients have raised great concerns. Our study aimed to identify these predictive factors for GG upgrading from biopsy to RP.</p>\u0000 <p><b>Methods:</b> We retrospectively reviewed the records of PCa patients receiving RP in our medical center. All patients underwent a standardized 12-core transrectal ultrasound (TRUS)–guided prostate needle biopsy, with site-specific submissions. Pretreatment PSA–related parameters were assessed 2 weeks before the operation. Prostate volume (PV) was calculated from images.</p>\u0000 <p><b>Results:</b> 679 patients were enrolled after screening. In the biopsy GG 1–3 group, 91 patients experienced upgrades. The multivariable analysis revealed that total PSA (tPSA) (<i>p</i> value &lt; 0.01) and perineural invasion (<i>p</i> value = 0.01) were significantly associated with the likelihood of upgrading compared to the concordant group.</p>\u0000 <p><b>Conclusion:</b> The GG 4 group demonstrated the lowest rate of concordance between biopsy and RP. Our analysis identified tPSA levels and perineural invasion as independent predictors of GG upgrading from biopsy GG 1–3 to RP GG 4–5 in PCa patients.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9940460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘Death Doulas’ are not yet an Issue in German Palliative Care—A National Survey of Palliative Care Providers","authors":"Christian Volberg,&nbsp;Aboud Makdsi,&nbsp;Jannis Eersink,&nbsp;Juliana Kushner,&nbsp;Astrid Morin,&nbsp;Martin Gschnell","doi":"10.1155/ecc/6654399","DOIUrl":"https://doi.org/10.1155/ecc/6654399","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The support of ‘Death Doulas’ (DD) in the last phase of life is becoming more and more present in the individual care of the dying. This trend is slowly being brought to Germany from other countries. However, the extent to which this possibility of end-of-life care is offered in Germany or requested by patients is still unclear.</p>\u0000 <p><b>Aim:</b> With this nationwide survey, we want to show to what extent DD support palliative care in Germany and whether a need for this activity is seen.</p>\u0000 <p><b>Design:</b> Germany-wide cross-sectional study among palliative care institutions.</p>\u0000 <p><b>Setting/Respondents:</b> All German hospices, palliative care units and specialized outpatient palliative care services were contacted by post and asked to participate in this anonymous survey.</p>\u0000 <p><b>Results:</b> In total, we received 338 (36.4%) responses. A total of 27% of the respondents state that they are familiar with the term DD but only 18 institutions (5.3%) use the support. Patients’ satisfaction is recognized as overall satisfied. A total of 95% of the institutions who work with DD would recommend other palliative care institutions to work with DD as well. More information about this topic is wished by 61%.</p>\u0000 <p><b>Conclusion:</b> DD is not yet an issue in German palliative care. There seems to be little need as the support of the dying is carried out by other professional groups and volunteers. Since DD have another approach in their work, it would be interesting to see if a broader knowledge about their work and offer could improve quality in the dying process.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6654399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is “Coaching” in Interventions for Patients in Cancer Care Research? A Systematic Scoping Review","authors":"P. Gérain,&nbsp;R. Tanious,&nbsp;W. Jacquet,&nbsp;A. Meziani,&nbsp;E. Van Hoof","doi":"10.1155/ecc/2858931","DOIUrl":"https://doi.org/10.1155/ecc/2858931","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> Cancer has an impact on psychosocial well-being as well as on mental health. Coaching increasingly appears as a source of psychosocial support to cancer patients. However, we currently lack a clear framework for coaching in that context. The present review aims to better define the concept of coaching in interventions for patients in cancer care research, as well as to synthesize frameworks, techniques, and providers.</p>\u0000 <p><b>Methods:</b> A conceptual scoping review based on PRISMA was performed on studies focusing on coaching and cancer published in peer-reviewed journals until November 2024. Studies on coaching and cancer were systematically extracted from five online databases and then screened.</p>\u0000 <p><b>Results:</b> A total of 237 studies were included after screening. Less than 15% of the studies provided an explicit definition of coaching. Six coaching categories were identified based on their goal, in addition to a general form of coaching. Coaching in cancer care occurs during the acute treatment phase as well as during the posttreatment phase. Most providers were healthcare professionals, despite an important heterogeneity. Techniques were sorted into 9 sets of techniques implemented in coaching interventions, including goal setting, providing support, and self-regulation.</p>\u0000 <p><b>Conclusions:</b> This review provided structure to the field of coaching in cancer. It also showed that defining a field only on the word “coaching” does not appear sufficient to reflect the current heterogeneity. Consequently, there is a necessity for the field to clarify its theoretical frameworks, targets, and intervention components to increase the necessary reproducibility and cumulative knowledge.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/2858931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in the Diagnostic and Treatment Pathway in Peritoneal Mesothelioma: A Mixed-Methods Study in the United Kingdom","authors":"Samantha Westbrook,&nbsp;Stephanie Ejegi-Memeh,&nbsp;Virginia Sherborne,&nbsp;Clare Warnock,&nbsp;Emily Wood,&nbsp;Sophia Stanford,&nbsp;Rayan Taher,&nbsp;Lorraine Creech,&nbsp;Lynne Squibb,&nbsp;Caroline Twist,&nbsp;Clare Gardiner","doi":"10.1155/ecc/8875835","DOIUrl":"https://doi.org/10.1155/ecc/8875835","url":null,"abstract":"<div>\u0000 <p>Peritoneal mesothelioma (PM) is a rare and aggressive cancer with a significant impact on the patient quality of life. This study aimed to explore variability in the care pathway of people with PM and to explore the patient experience of the care pathway. A mixed-methods, longitudinal approach was employed. The three stages of the study were (1) cross-sectional survey of PM patients and family members exploring demographic characteristics, patient pathway, experiences of treatment and care; (2) qualitative, case study series of individual patients, their family member/carer/friend and professionals; and (3) case note review of case study patients living with PM. Forty-seven patients (30 women and 17 men) responded to the survey. We recruited seven case studies comprising seven patient participants, eight carers and six professionals. Findings revealed a significant delay in diagnosis due to nonspecific symptoms and challenges in differential diagnosis. The study highlights the need for improved timely diagnosis, enhanced communication between healthcare providers and patients, and referral to specialist mesothelioma multidisciplinary teams. Recommendations include the need to implement smoother treatment and management pathways, to increase referrals to specialist multi-disciplinary teams and to engage patients in decision-making throughout the treatment pathway.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8875835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Venous Thromboembolism After Radical Hysterectomy in Patients With Cervical Cancer","authors":"Bei Feng,&nbsp;Zehua Wang,&nbsp;Liqiong Cai,&nbsp;Xiaoqi He,&nbsp;Yuan Zhang,&nbsp;Jing Cai","doi":"10.1155/ecc/9573736","DOIUrl":"https://doi.org/10.1155/ecc/9573736","url":null,"abstract":"<div>\u0000 <p>This retrospective study aimed to determine the risk factors for venous thromboembolism (VTE) in patients undergoing radical hysterectomy for cervical cancer. Data from 366 patients who underwent radical surgery between June 2020 and December 2021 were collected from medical records. The patients were divided into a thrombosis group and a nonthrombotic group based on the presence or absence of VTE. Multivariate analyses revealed that age greater than 45 years, open radical hysterectomy surgery, an operation time exceeding 4 hours, intraoperative blood transfusion, and postoperative plasma D-dimer levels greater than 2.0 mg/L were significant independent risk factors for postoperative VTE, which could be used to help identify patients at an increased risk of VTE.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9573736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating What Is Not Known—Patients’ Experience of the Life Threat Connected to Allogeneic Stem Cell Transplantation","authors":"Alinda Reimer,&nbsp;Carolin Schepers,&nbsp;Merle Ley,&nbsp;Berenike Schoerger,&nbsp;Anne Pralong,&nbsp;Raymond Voltz,&nbsp;Udo Holtick,&nbsp;Marco Herling,&nbsp;Steffen T. Simon","doi":"10.1155/ecc/8743444","DOIUrl":"https://doi.org/10.1155/ecc/8743444","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Allogeneic stem cell transplantation (allo-SCT) represents a firmly established therapeutic option for patients facing (non-)malignant haematological diseases. Despite its curative potential, however, this treatment is associated with substantial morbidity and mortality rates as well as a decreased quality of life. Given this context, a scientific void needs to be addressed: How do patients deal with the existential situation of being exposed to a life threat despite the curative potential of their treatment? This study aims to explore the patients’ experiences considering their life threat in the context of the allo-SCT.</p>\u0000 <p><b>Methods:</b> Qualitative semistructured, in-depth interviews were conducted with patients treated by allo-SCT over the course of transplantation (before, during or after hospitalization). Interview data were interpreted using category-based qualitative content analysis.</p>\u0000 <p><b>Results:</b> Seventeen interviews were conducted. Results revealed a strong focus on hope and avoidance of dealing with the life threat. At the same time, challenges due to the lack of alternative treatments and the uncertain course were highlighted. The data revealed that patients wished to receive support by healthcare professionals, their carers and their social environment in general. Beyond that, patients desired to obtain honest information within an open discussion about a realistic prognosis and risk of treatment and course of disease.</p>\u0000 <p><b>Conclusion:</b> The findings emphasize an interplay between hope, avoidance and psychological distress in the face of the patients’ life threat. To assist allo-SCT recipients in navigating their life threat during treatment, it is desirable to establish avenues that provide adequate support.</p>\u0000 <p><b>Trial Registration:</b> German Registry of Clinical Trials: DRKS00027290</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8743444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated CA15-3 Levels in Myeloid Disorders: Clinicopathological Correlation","authors":"Samah Saharti,&nbsp;Mohamad Qari","doi":"10.1155/2025/5824491","DOIUrl":"https://doi.org/10.1155/2025/5824491","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Serum tumor markers are beneficial to patients with advanced cancer because they help in early diagnosis, determining prognosis, predicting response to certain medications, and monitoring therapy. The prognostic value of cancer antigen 15-3 (CA15-3) serum-level changes in breast cancer is very well established. The main cause behind the elevation of CA 15-3 is metastatic breast carcinoma. In this study, we will run a record review to study comprehensively the clinical association between chronic myeloid disorders and CA15-3 elevation.</p>\u0000 <p><b>Method:</b> In this retrospective study, we run CA15-3 on 106 patients with different myeloid disorders diagnosed between 2008 and 2021 from several tertiary care centers in Saudi Arabia, Jeddah, majority of which (38 cases) were diagnosed with chronic myeloid leukemia (35.8%). Others had essential thrombocytosis (22.6%), chronic myeloproliferative neoplasm (20.8%), myelofibrosis (7.5%), acute myeloid leukemia (4.7%), myelodysplastic syndrome (4.7%), and polycythemia vera (3.8%).</p>\u0000 <p><b>Result:</b> An increase in CA15-3 was seen in 50% of all cases. In particular, polycythemia vera showed an elevation in 100% of the cases (4 out of 4). Second in expressivity is myelodysplastic syndrome (80%, 4 out of 5 cases). Close in value is myelofibrosis (75%, 6 out of 8 cases). The least association is noted between CA15-3 and essential thrombocytosis (16.7%, 4 out of 24 cases).</p>\u0000 <p><b>Conclusion:</b> When CA15-3 levels are considered during the time of myeloid disorder diagnosis, it shows an independent predictive value. More research is needed to determine the utility of these serum biomarkers in myeloid disorders decision-making. This is a thorough case series of chronic myeloid disorders inclusive of all myeloproliferative neoplasms besides myelodysplastic syndrome describing the association with CA15-3.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2025/5824491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}