European Journal of Cancer Care最新文献

{"title":"Lower Functional Status, Higher Comorbidity Burden, and Higher Levels of Stress Are Associated With Worse Joint Evening Fatigue and Depressive Symptom Profiles in Outpatients Receiving Chemotherapy","authors":"Carolyn S. Harris,&nbsp;Bruce A. Cooper,&nbsp;Kate R. Oppegaard,&nbsp;Joosun Shin,&nbsp;Lisa Morse,&nbsp;Steven M. Paul,&nbsp;Marilyn J. Hammer,&nbsp;Jon D. Levine,&nbsp;Yvette P. Conley,&nbsp;Christine A. Miaskowski","doi":"10.1155/ecc/9954939","DOIUrl":"https://doi.org/10.1155/ecc/9954939","url":null,"abstract":"<div>\u0000 <p><b>Significance:</b> Evening fatigue and depressive symptoms are associated with several negative outcomes for patients with cancer. However, the contribution of BOTH fatigue and depressive symptoms to patient outcomes remains unknown. This study identified subgroups of patients with distinct joint evening fatigue AND depressive symptom profiles and evaluated for differences in demographic and clinical characteristics, levels of stress (i.e., global, cancer-specific, and cumulative life) and resilience, and the severity of common symptoms.</p>\u0000 <p><b>Methods:</b> Outpatients (<i>n</i> = 1334) completed the Lee Fatigue Scale and Center for Epidemiological Studies-Depression scale six times over two cycles of chemotherapy. Demographic and clinical characteristics, stress and resilience, and other common symptoms were assessed at enrollment. Joint evening fatigue and depressive symptom profiles were identified using latent profile analysis. Profile differences were assessed using parametric and nonparametric tests.</p>\u0000 <p><b>Results:</b> Five profiles were identified (i.e., Low Evening Fatigue and Low Depression [Both Low: 20.0%], Moderate Evening Fatigue and Low Depression [Moderate Fatigue and Low Depression: 39.3%], Increasing and Decreasing Evening Fatigue and Depression [Both Increasing–Decreasing: 5.3%], Moderate Evening Fatigue and Moderate Depression [Both Moderate: 27.6%], High Evening Fatigue and High Depression [Both High: 7.8%]). Compared to the Both Low and Moderate Fatigue and Low Depression classes, the Both Moderate and Both High classes were less likely to be married, more likely to report depression, had a lower functional status, and had worse comorbidity profile. Both Moderate and Both High classes had higher levels of global, cancer-specific, and cumulative life stress and lower resilience.</p>\u0000 <p><b>Conclusions:</b> Multiple risk factors for higher levels of evening fatigue AND depressive symptoms during chemotherapy were identified, including lower functional status, higher comorbidity burden, lower levels of resilience, and higher global, cancer-specific, and cumulative life stress. These risk factors may be used to identify patients at greatest risk for poorer outcomes and to prescribe interventions to decrease these symptoms.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9954939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Chemotherapy-Induced Oral Mucositis, Nutritional Status, and Depression in Patients With Acute Leukemia","authors":"Juhee Song,&nbsp;Hannah Yu,&nbsp;Eunjung Ryu","doi":"10.1155/ecc/7989087","DOIUrl":"https://doi.org/10.1155/ecc/7989087","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Chemotherapy, a fundamental treatment modality for acute leukemia, is linked to significant adverse effects such as oral mucositis, nutritional decline, and depression, all of which markedly impact patient outcomes.</p>\u0000 <p><b>Objective:</b> This study aimed to evaluate the progression of chemotherapy-induced oral mucositis and its impact on nutritional status and depression in patients with acute leukemia.</p>\u0000 <p><b>Methods:</b> In this prospective descriptive study, 123 patients aged 19–70 years diagnosed with acute leukemia were recruited from a tertiary hospital through convenience sampling. These patients were scheduled for remission-induction, consolidation, or reinduction chemotherapy. Initially, 140 patients were enrolled, with 123 participants included in the final analysis after accounting for incomplete responses and dropouts. Oral mucositis, nutritional status, and depression were assessed using validated scales, with follow-up evaluations conducted 10 days post-chemotherapy. Oral mucositis was assessed using the WHO Mucositis Grading Scale, symptom experiences were measured with the MD Anderson Symptom Inventory, nutritional status was evaluated with the Patient-Generated Subjective Global Assessment (PG-SGA), and depression was assessed using the 10-item Center for Epidemiological Studies Depression Scale (CES-D-10). Statistical analyses included paired <i>t</i>-tests, ANOVA, and multiple regression.</p>\u0000 <p><b>Results:</b> Compared to baseline, all the variables evaluated—oral mucositis, symptoms experiences, nutritional status, and depression—were significantly worsened on day 10 after chemotherapy. Regression analysis identified muscle weakness and skin problems as significant factors of depression. Additionally, patients receiving remission-induction therapy presented significantly worse depression than those receiving consolidation therapy.</p>\u0000 <p><b>Conclusion:</b> This study highlighted the rapid deterioration of symptoms after chemotherapy in patients with acute leukemia. This underscores the need for a multidisciplinary approach that emphasizes nutritional support, emotional support, and evidence-based nursing interventions tailored to specific groups of symptoms. Future research should explore the educational interventions delivered during initial hospitalization and their effectiveness, particularly in patients receiving remission-induction therapy.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7989087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Caregivers’ Experiences of Hospital at Home Following Allogeneic Haematopoietic Stem Cell Transplantation: A Qualitative Study","authors":"Sigrid Cecilie Tinglum Skøyeneie,&nbsp;Hilde Skuterud Wik,&nbsp;Geir Erland Tjønnfjord,&nbsp;Lena Fauske,&nbsp;Tobias Gedde-Dahl,&nbsp;Anders Eivind Myhre","doi":"10.1155/ecc/7043910","DOIUrl":"https://doi.org/10.1155/ecc/7043910","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> The use of Hospital at Home (HaH) is expanding globally, including in the context of allogeneic haematopoietic stem cell transplantation (HSCT), as an innovative care model that delivers hospital-equivalent care to patients in a home setting. The HaH model designed for HSCT relies on informal caregivers, such as next of kin or friends. Given the limited research on caregivers’ perceptions of HaH, this study aimed to explore how informal caregivers of patients undergoing HSCT experienced HaH.</p>\u0000 <p><b>Method:</b> Using a phenomenological interpretive approach, semistructured individual interviews were conducted with 14 family caregivers. Data were analysed using reflexive thematic analysis.</p>\u0000 <p><b>Results:</b> The analysis identified three themes: (1) On the inside as a caregiver, (2) Variation in caregiver burden and (3) Appreciating normality. Caregivers valued the opportunity to be physically present and involved in caring for the patient during HSCT. Although most had to undertake an active caregiving role, they reported varying levels of involvement and distress. Caregivers also highlighted the sensation of normality that HaH fostered, emphasising that maintaining a familiar routine in the home setting was less exhausting than traditional hospital care.</p>\u0000 <p><b>Conclusion:</b> This study found that family caregivers appreciated being physically present in HaH, experiencing a sensation of being ‘on the inside’ and closely sharing the patient’s treatment journey, in contrast to during hospitalisation. The findings revealed diverse experiences of caregiving and associated distress, underscoring the importance of adequately preparing caregivers for their role and ensuring appropriate support.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7043910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Care Needs of Women With Breast Cancer and the Time From Diagnosis to Treatment: A Qualitative Study","authors":"Mahboubeh Sadat Yousefi,&nbsp;Mahnaz Ilkhani,&nbsp;Mohammad Esmaeil Akbari,&nbsp;Sima Zohari Anboohi,&nbsp;Fatemeh Heshmati Nabavi","doi":"10.1155/ecc/8896043","DOIUrl":"https://doi.org/10.1155/ecc/8896043","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Breast cancer is the most common type of cancer in Iranian women. Early needs assessment of patients at the time of diagnosis and across the phases of cancer treatment is essential to provide timely and appropriate supportive care. Therefore, the present study aims to explore the care needs of breast cancer patients from the time of diagnosis to treatment completion.</p>\u0000 <p><b>Methods:</b> This qualitative research was conducted as a conventional content analysis, based on the Graneheim and Lundman approach. Eighteen participants, consisting of breast cancer patients, family members, oncology nurses, and oncologists, were selected using a purposive sampling method with maximum diversity. Data were collected using in-depth semistructured interviews and entered into the MAXQDA 2020 software for analysis. Lincoln and Guba’s criteria for credibility, transferability, dependability, and confirmability were used to validate the research findings.</p>\u0000 <p><b>Results:</b> The needs of women with breast cancer in the diagnosis and treatment phases were categorized into two and seven categories and five and 18 subcategories, respectively. The themes that emerged relating to women’s needs at the time of diagnosis included psychoemotional and informational needs. The needs of women in the treatment phase were categorized into the following themes: informational, practical, psychoemotional, physical, spiritual, communication, and sexual needs.</p>\u0000 <p><b>Conclusions:</b> This study provides valuable insights into optimal and patient-oriented supportive care, accounting for the numerous needs of patients with breast cancer. Healthcare providers should provide supportive care according to patients’ needs and preferences, which will lead to the correct use of resources and cost reduction as well as improving the quality of life of cancer patients. Supportive care needs are culture-dependent. Thus, cultural issues must be considered when developing an effective supportive care program.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8896043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Patient-Reported Outcomes in Patients With Osteosarcoma: A Systematic Review","authors":"Ana Sebio,&nbsp;Claire Berger,&nbsp;Marie-Dominique Tabone,&nbsp;Natalia Fernandez,&nbsp;Faustine Tardy,&nbsp;Martha Grootenhuis,&nbsp;Emanuela Palmerini,&nbsp;Nathalie Gaspar,&nbsp;Michiel van de Sande,&nbsp;Lianne M. Haveman,&nbsp;The FOSTER Consortium","doi":"10.1155/ecc/5802523","DOIUrl":"https://doi.org/10.1155/ecc/5802523","url":null,"abstract":"<div>\u0000 <p>Patients diagnosed with osteosarcoma undergo intensive multimodality treatment that can lead to long-term adverse effects, significantly impacting various aspects of daily living. To objectively assess the Health-Related Quality of Life (HR-QoL) in pediatric and adult populations, several Patient-Reported Outcome Measurements (PROMs) are available. However, these questionnaires often exhibit substantial variability in the domains and items they encompass, frequently failing to address aspects that are particularly important after osteosarcoma treatment. A systematic review was conducted to identify the most frequently used questionnaires concerning QoL in pediatric and adult patients with osteosarcoma and to examine the diverse domains and subdomains of QoL assessed by these questionnaires to identify gaps in their coverage, to recommend suitable instruments for an upcoming European trial within the Fighting Osteosarcoma Through European Research (FOSTER) Consortium. English-language literature published since 1980 in PubMed was reviewed. One hundred twenty-eight articles were initially screened for eligibility. Sixty-three original articles were included in the qualitative synthesis. An overview from review articles was given. Selected studies displayed substantial heterogeneity in terms of their objectives, target populations, age ranges, follow-up time, and number of patients included. None of the questionnaires covered all age groups and addressed all important aspects following osteosarcoma treatment. To comprehensively address as many relevant aspects as possible, a combination of questionnaires is suggested. For the adult population, it is recommended to use the EORTC-QLQ-C30 questionnaire together with the Body Image Scale (BIS), while for pediatric patients, the PedsQl-generic and PedsQl-cancer-specific questionnaires and BIS (&gt; 16 years) are suggested. The use of Patient-Reported Outcome Measurement Information Systems (PROMIS) can provide a comprehensive assessment of symptoms such as anxiety, pain, and fatigue. The development of new bone sarcoma-specific, pediatric and adult self-reported questionnaires, or the validation and translation of existing bone sarcoma-specific questionnaires, along with the utilization of new digital possibilities, holds great value for upcoming trials.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5802523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Perceptions of Patients, Carers and Clinicians Relating to SACT Decision-Making in Older People With Cancer: Qualitative Findings From the Electronic Frailty Index (eFI) in Cancer Study","authors":"Katie Sutton,&nbsp;Jo Armes,&nbsp;Simon S. Skene,&nbsp;Janine Mansi,&nbsp;Agnieszka Michael","doi":"10.1155/ecc/4399728","DOIUrl":"https://doi.org/10.1155/ecc/4399728","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To explore the perceptions and experiences of patients, carers and clinicians relating to treatment decision-making in older people with cancer, and to investigate the acceptability of the eFI as a tool to influence decisions about SACT.</p>\u0000 <p><b>Methods:</b> Qualitative interviews were conducted with 28 participants (12 clinicians, 10 patients and 6 carers) at an NHS cancer day unit in South East England. Patients were &gt; 60 years and had received at least one cycle of SACT. Data were analysed using framework analysis.</p>\u0000 <p><b>Results:</b> Two themes were identified. Theme one highlighted that the assessment of frailty is a variable and complex task. However, an individualised assessment incorporating a balance between quality of life and the potential benefit of treatment is fundamentally important. Theme two identified that eFI is an acceptable addition to SACT decision-making which must be discussed with the patient and considered within the context of each individual situation.</p>\u0000 <p><b>Conclusion:</b> The eFI is acceptable for use in assessing the frailty of older people with cancer prior to starting SACT. In-depth, individualised assessment prior to SACT is important in this population, but it is not always realistic. Incorporating the eFI into SACT decision-making offers the potential to address this challenge.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/4399728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Needs in Parental Cancer: A Qualitative Analysis of Contextual Factors From the Perspective of Healthy Parents—Results From the Family-SCOUT Study","authors":"Johanna Weiß,&nbsp;Nicole Ernstmann,&nbsp;Christian Heuser,&nbsp;Hannah Nakata,&nbsp;Evamarie Brock-Midding,&nbsp;Rebecca Horbach-Bremen,&nbsp;Tim H. Brümmendorf,&nbsp;Manuela Brüne,&nbsp;Marc Dohmen,&nbsp;Barbara Drueke,&nbsp;Franziska Geiser,&nbsp;Steffen Holsteg,&nbsp;Andrea Icks,&nbsp;André Karger,&nbsp;Jens Panse,&nbsp;Andrea Petermann-Meyer,&nbsp;Anja Viehmann,&nbsp;Lina Heier","doi":"10.1155/ecc/7707431","DOIUrl":"https://doi.org/10.1155/ecc/7707431","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Parental cancer affects the whole family and can have negative impact on family as a system as well as on single family members. This multicentre, prospective, interventional and non-randomized family-SCOUT study aimed to implement a comprehensive psychosocial intervention to provide support for the family during and after the disease. The purpose of this study is to analyse the contextual factors that impact the subjective perceived effectiveness of family-scout support for families affected by parental cancer from the healthy parents’ perspective.</p>\u0000 <p><b>Methods:</b> Semi-structured interviews with the healthy parent as a surrogate of family-SCOUT families from the intervention group were conducted. All interviews were audio-recorded, transcribed and analysed using template analysis.</p>\u0000 <p><b>Results:</b> Within two years, 23 interviews were conducted. Four themes were identified, highlighting contextual factors that indicate successful support for families: Ability to meet the support needs of families; cancer as a family disease—burdens in the context of the family system; coping strategies—how the individual family members deal with the situation and communication within the family.</p>\u0000 <p><b>Conclusion:</b> Family-scouts can provide beneficial support to families affected by parental cancer, but individual time of the families, communication and stress factors need to be taken into consideration.</p>\u0000 <p><b>Trial Registration:</b>​ Familien-SCOUT: NCT04186923</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7707431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns of Women With Breast Cancer During Their Therapy in Iran: A Qualitative Investigation","authors":"Nasrin Sadidi,&nbsp;Armita Shahesmaeili,&nbsp;Parvin Mangolian Shahrbabaki,&nbsp;Mohammad Ali Zakeri,&nbsp;Behjat Kalantari Khandani,&nbsp;Aliakbar Haghdoost","doi":"10.1155/ecc/3157813","DOIUrl":"https://doi.org/10.1155/ecc/3157813","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> Women with breast cancer (BC) may have dreadful experiences mainly because of the severity of their disease, the complications of treatments, and its psychological burden. In this study, we explored the concerns of BC cases in Iran. Therefore, this study aimed to investigate the problems of BC patients from the beginning of treatment and its continuation in Kerman city.</p>\u0000 <p><b>Methods:</b> This qualitative descriptive–explorative study was conducted using a conventional content analysis approach to investigate the concerns of women with BC during their therapy in Iran. A total of 30 women with BC were included in the study through purposive sampling. Data were collected through in-depth, semi-structured interviews. The study process lasted from November 2019 to December 2022.</p>\u0000 <p><b>Results:</b> Three hundred and twenty codes, 1 main category, 3 categories, and 16 subcategories were extracted. Based on the participants’ experiences, women with BC face various concerns during their treatment: (1) physical and psychological problems, (2) family and social problems, and (3) organizational problems.</p>\u0000 <p><b>Conclusion:</b> This study shows that most of the concerns of BC are related to psycho-emotional problems, easy access to medicine and treatment costs, and other economic problems. This clearly shows the urgent need of these patients for regular counseling and follow-up and more support in the field of financing. Addressing concerns before treatment, particularly among women who are considered a vulnerable group in society, can assist researchers and specialists in planning counseling and necessary follow-ups to reduce these patients’ anxiety and support their rehabilitation after treatment. Attention to the necessary psychological and social support for these patients may also help improve their adaptation.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3157813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the SUMOylation Gene Signature in Colon Cancer by Transcriptome and Mendelian Randomization Integration","authors":"Xiaobin Zhang,&nbsp;Qingshui Yang,&nbsp;Zongyu Liang,&nbsp;Zhu Li,&nbsp;Chunlei Lu","doi":"10.1155/ecc/8659536","DOIUrl":"https://doi.org/10.1155/ecc/8659536","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> SUMOylation is a posttranslational protein modification, which is involved in tumorigenesis, aggression, metastasis, drug resistance, and prognosis, while the molecular characteristics and prognostic values of the SUMOylation remain unclear.</p>\u0000 <p><b>Methods:</b> The transcriptomic data were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), and summary-level data of genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL) from European ancestry were collected. The SUMOylation patterns of CRC patients, tumor microenvironment (TME) immune cell infiltrating characteristics, biological function therapeutic responses, and prognostic signatures were identified. Mendelian randomization (MR) analysis explored the causality between prognostic signatures and CRC.</p>\u0000 <p><b>Results:</b> Three SUMOylation-related clusters were classified, and Cluster 2 showed the worst survival status, most populations of infiltrated immune cells, responses to anti-CTLA-4 and anti-PD-1 therapies, and sensitivity to chemotherapy. Nine SUMOylation-related signatures (NDC1, PPARGC1A, CDKN2A, UHRF2, NUP54, PIAS3, H4C4, CHD3, and SUMO2) were selected and validated as prognostic signatures. A predictive nomogram was constructed and validated. Finally, NUP54 was positive, but PPARGC1A was negatively associated with the risk of CRC.</p>\u0000 <p><b>Conclusion:</b> This study first comprehensively explored the molecular characteristics and prognostic values of SUMOylation and identified the possible biomarkers for treatment in CRC.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8659536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZDHHC9 as a Potential Biomarker for Prognostic Evaluation and Diagnostic Identification in BRCA, CESC, HNSC, and KIRP Tumors","authors":"Qunlong Liu,&nbsp;Wenxia Li,&nbsp;Ming Xie,&nbsp;Ming Yang,&nbsp;Mei Xu,&nbsp;Lei Yang,&nbsp;Mengru Sun,&nbsp;Yanna Peng,&nbsp;Li Gao","doi":"10.1155/ecc/2641908","DOIUrl":"https://doi.org/10.1155/ecc/2641908","url":null,"abstract":"<div>\u0000 <p>An expanding corpus of evidence suggests that zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9) may represent a promising biomarker in various malignancies. Noteworthy is the fact that ZDHHC9 has been discovered to be significantly upregulated in specific varieties of human gastrointestinal cancers. Nevertheless, the precise role it plays in tumor prognostic evaluation and diagnostic identification remains ambiguous. In this study, we commenced with a thorough investigation of ZDHHC9 expression by leveraging the extensive and comprehensive TCGA database. This resource offers a wealth of valuable information and data samples, which enabled a more comprehensive and thorough analysis. The expression levels of ZDHHC9 in BRCA, CESC, HNSC, and KIRP were thoroughly investigated, revealing a significant elevation compared to normal tissues. This significant escalation was observed to be intimately linked with an adverse prognosis. A comprehensive analysis of the data revealed that the increased expression of ZDHHC9 in these particular cancer types was associated with poorer outcomes for patients. The extensive study examining various cancer types has yielded significant insights regarding the function of ZDHHC9, as well as its potential implications for prognosis and therapeutic strategies. Functional predictions indicate that immune or metabolic disorders, as well as the activation of carcinogenic signaling pathways due to abnormal expression of ZDHHC9, may significantly contribute to tumor progression and poor prognosis in patients. This further corroborates the influence of ZDHHC9 on the migration and invasion capabilities of CESC cell lines. ZDHHC9 is a key target for therapeutic and diagnostic use in BRCA, CESC, HNSC, and KIRP tumors, contributing significantly to the understanding of molecular tumor treatments.</p>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/2641908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}