European Journal of Cancer Care最新文献

{"title":"The Effect of Hand Massage on Pain Management After Breast Cancer Surgery: A Narrative Review","authors":"Tugba Albayram,&nbsp;Kiymet Oztepe Yesilyurt,&nbsp;Cemile Celebi","doi":"10.1155/ecc/3087696","DOIUrl":"https://doi.org/10.1155/ecc/3087696","url":null,"abstract":"<p>Postoperative pain following breast cancer surgery remains a significant clinical challenge and may negatively affect recovery and quality of life if inadequately managed. In recent years, nonpharmacological nursing interventions have gained increasing attention as adjuncts to pharmacological pain control. This narrative review aimed to summarize the available evidence regarding the short-term effects of hand massage on postoperative pain among women undergoing breast cancer surgery. A literature search was conducted using PubMed, CINAHL, ScienceDirect, and Google Scholar to identify studies published between July 2024 and June 2025. Clinical and experimental studies evaluating the effect of hand massage on postoperative pain intensity, anxiety, or analgesic use were considered eligible. Due to the limited availability of recent evidence, one earlier highly relevant controlled study was also included to contextualize the current findings. In total, three studies (one randomized controlled trial and two quasi-experimental studies) met the inclusion criteria. Across the included studies, hand massage was associated with short-term reductions in pain intensity and anxiety during the early postoperative period. However, considerable heterogeneity was observed in massage protocols, study designs, and outcome measures. Small sample sizes and methodological limitations further restrict the strength and generalizability of the evidence. In conclusion, hand massage may be considered an exploratory supportive adjunctive nursing intervention for postoperative pain management after breast cancer surgery. However, the current evidence base remains limited, heterogeneous, and methodologically constrained, requiring cautious interpretation before any clinical recommendations can be made.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3087696","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-Emotional Selectivity in Patients With Severe Chronic or Life-Threatening Conditions: A Systematic Review of Changes in Social Goals and Psychological Well-Being in Alzheimer’s Disease and Cancer","authors":"Christina Ingwald,&nbsp;Mara Mussehl,&nbsp;Robert Gaschler","doi":"10.1155/ecc/7882599","DOIUrl":"https://doi.org/10.1155/ecc/7882599","url":null,"abstract":"<p>Theory of socio-emotional selectivity (SST) posits that social goals and emotional priorities shift when individuals perceive their remaining lifetime as limited. While well established in aging, its relevance in severely ill patients is underexplored. This systematic review focuses on Alzheimer’s disease and cancer as conditions marked by a limited time perspective. Thirteen empirical studies were analyzed regarding (1) prioritization of emotionally meaningful relationships, (2) the role of disease progression in intensifying social selectivity, (3) links between social embedding and psychological adaptation, and (4) the role of perceived time horizon. Findings consistently support SST: patients prioritize close emotional bonds, with selectivity increasing as illness advances. Strong emotional networks are associated with greater psychological resilience and reduced distress. These results highlight the clinical value of fostering meaningful social connections in severely ill individuals. Future research should clarify causal mechanisms, particularly the mediating role of time perception, expand to other neurodegenerative conditions, and develop interventions suited to patients with cognitive or physical limitations.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7882599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Immunotherapy Options in HER-2-Positive Metastatic Breast Cancer: A Meta-Analysis on Clinical Effectiveness and Safety of T-DM1, Trastuzumab−Pertuzumab, and Trastuzumab Deruxtecan","authors":"Anulika Maris Omeaku,&nbsp;Anfal Anwar Sharif,&nbsp;Jameel Malhador Inal","doi":"10.1155/ecc/3726620","DOIUrl":"https://doi.org/10.1155/ecc/3726620","url":null,"abstract":"<p>HER-2-positive metastatic breast cancer (MBC) remains a clinical challenge due to its aggressive nature and resistance to conventional therapies. This meta-analysis compares the clinical effectiveness and safety profiles of three key targeted immunotherapies: trastuzumab emtansine (T-DM1), trastuzumab−pertuzumab, and trastuzumab deruxtecan, focusing on overall survival (OS), progression-free survival (PFS), and adverse event profiles. Eligible studies were retrieved from PubMed and filtered for randomized controlled trials (RCTs) published between January 2019 and June 2024. Nonrandomized studies, reviews, and editorials were excluded. Data from four studies were included in the meta-analysis, which was performed using RevMan software. The findings show that T-DM1 presents a favorable balance between efficacy and safety, particularly in patients with prior trastuzumab-based treatments. While trastuzumab deruxtecan demonstrated superior efficacy in heavily pretreated patients, it was associated with a higher risk of severe adverse events, particularly interstitial lung disease (ILD). Trastuzumab−pertuzumab remains the preferred first-line treatment but shows reduced effectiveness in later treatment lines. Overall, while all three treatment regimens provide significant benefits for patients with HER-2-positive MBC, T-DM1 emerges as a safer option for patients with cardiotoxicity risks. Trastuzumab−pertuzumab offers the best balance between efficacy and safety, while trastuzumab deruxtecan offers superior effectiveness in patients with advanced disease stages. These findings emphasize the importance of personalized treatment plans in optimizing clinical outcomes.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3726620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Ozone Therapy in the Treatment of Radiotherapy- and Chemotherapy-Induced Mucositis: A Systematic Review","authors":"Andrea Butera,&nbsp;Maurizio Pascadopoli,&nbsp;Marco Zecca,&nbsp;Silvia Rosso,&nbsp;Anna Maria Grugnetti,&nbsp;Marco Monticone,&nbsp;Gaia Soressi,&nbsp;Andrea Scribante","doi":"10.1155/ecc/3205388","DOIUrl":"10.1155/ecc/3205388","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mucositis is a frequent complication of chemo- and/or radiotherapy treatments and causes great pain and discomfort to the affected patient. Ozone therapy is a widely studied treatment in numerous disciplines, first and foremost dermatology; the beneficial effects of this treatment have already been confirmed in this field, particularly in the healing of wounds caused by diabetes. However, there is a shortage of studies on the use of this treatment in the management of radio- and/or chemo-induced mucositis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This review aims to summarise current evidence on the beneficial effects of ozone treatment in the management of chemo- and/or radio-induced mucositis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature review was carried out on the main databases (Scopus, PubMed and WOS); for each of the included article, the analysis of risk of bias was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven articles were included in this systematic review, including six preliminary animal studies and one prospective cohort study. Analysing the variables of the studies, it seems that ozone is associated with a decrease in bacterial load, oedema and inflammatory infiltrate at the level of the lesions and a decrease in thiobarbituric acid reactive substances, indicators of oxidative stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The efficacy of ozone for the management of radio- and/or chemo-induced mucositis is still to be confirmed as current evidence provides only two clinical studies. However, beneficial effects were highlighted and deserve to be further investigated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3205388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Pulmonary Rehabilitation in Inoperable Advanced Lung Cancer: A Scoping Review","authors":"Huang Yi,&nbsp;Zeng Fan,&nbsp;Feng Lijuan","doi":"10.1155/ecc/5540540","DOIUrl":"https://doi.org/10.1155/ecc/5540540","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung cancer is the leading cause of cancer mortality worldwide. The role of pulmonary rehabilitation (PR) in patients with inoperable advanced lung cancer remains less defined due to disease severity and poor prognosis. This scoping review aims to map the characteristics, implementation methods, outcome metrics, and effectiveness of PR in this specific population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature search was conducted across PubMed, Web of Science, CINAHL, Embase, Cochrane, and OpenGrey databases up to October 2025, following JBI guidelines and the PRISMA-ScR checklist. Randomized controlled trials and nonrandomized intervention studies focusing on PR for patients with advanced lung cancer were included. The literature was screened and selected according to the PICOS framework, after which data were extracted and organized from the included studies and finally integrated using a narrative synthesis approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-two studies involving 1979 patients were included. Interventions were predominantly hospital-based, and core components included aerobic and resistance training. The intervention period ranged from 2 to 12 weeks, with the intensity primarily being moderate to high. Significant improvements were consistently reported in exercise capacity, muscle strength, and symptom burden. However, evidence regarding lung function and health-related quality of life remained heterogeneous. Completion rates varied from 44% to 100%, with disease progression being a primary barrier to adherence. None of the studies reported any serious adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PR is a safe and feasible intervention for patients with advanced lung cancer, offering clear benefits in terms of physical function and symptom management. However, maintaining high adherence remains a challenge. Future research should further explore home-based intervention models assisted by digital rehabilitation technologies and actively promote the integration of PR into multidisciplinary palliative care pathways.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5540540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Social Support on the Empowerment Status and Alopecia-Related Quality of Life in Breast Cancer Patients: A Cross-Sectional Structural Equation Modeling Study","authors":"Nisa Yavuzer Bayrak,&nbsp;Gülcan Bahcecioglu Turan,&nbsp;Elanur Yilmaz Karabulutlu","doi":"10.1155/ecc/6666093","DOIUrl":"https://doi.org/10.1155/ecc/6666093","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This cross-sectional study was conducted to investigate the effect of social support on empowerment status and alopecia-related quality of life in breast cancer patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 150 breast cancer patients who were admitted to the oncology outpatient clinic of a training and research hospital in Erzurum province, eastern Turkey, and met the inclusion criteria. Data were collected using the Descriptive Information Form, the Cancer Empowerment Scale, the Chemotherapy-Induced Alopecia Quality of Life Scale, and the Cancer Patient Social Support Scale. Structural equation modeling was used to examine the direct and indirect relationships among variables. This study was conducted in accordance with the STROBE guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Social support was found to positively affect empowerment status (<i>β</i> = 0.960) and alopecia-related quality of life (<i>β</i> = 0.335). Empowerment status had a positive and significant effect on alopecia-related quality of life (<i>β</i> = 0.647). The indirect effect of social support on alopecia-related quality of life through empowerment status was positive and significant (<i>β</i> = 0.622), and the total effect of social support on alopecia-related quality of life was also positive and significant (<i>β</i> = 0.957). Social support explained 92% of the variance in empowerment status, and the overall model explained 94% of the variance in alopecia-related quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Social support positively influences both empowerment status and alopecia-related quality of life in breast cancer patients. In addition, social support improves alopecia-related quality of life indirectly by enhancing empowerment status. Strengthening social support mechanisms may therefore contribute to improved quality of life related to chemotherapy-induced alopecia in breast cancer patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6666093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet-Based Telecare and Bibliotherapy Delivery of Acceptance and Commitment Therapy for Reducing Anxiety and Depression in Breast Cancer Patients: A Randomized Controlled Trial","authors":"Niloufar Baghelani,&nbsp;Mojtaba Miladinia,&nbsp;Mina Jahangiri,&nbsp;Kourosh Zarea","doi":"10.1155/ecc/7802902","DOIUrl":"https://doi.org/10.1155/ecc/7802902","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the effectiveness of Internet-based acceptance and commitment therapy (iACT) and bibliotherapy-based ACT (bACT) in reducing anxiety and depression among women with breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this three-arm randomized controlled trial, 99 participants were recruited from three oncology centers in Iran and randomly assigned to iACT, bACT, or a control group (<i>n</i> = 33 each). Interventions lasted 6 weeks with a 4-week follow-up. The Beck Anxiety Inventory and Beck Depression Inventory-Short Form were used to assess outcomes at baseline, post-intervention, and follow-up. Data were analyzed using generalized estimating equations (GEE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The iACT group showed significantly greater reduction in depression and anxiety than the control group at post-intervention and follow-up (all <i>p</i> &lt; 0.001, except for post-intervention anxiety in iACT group was <i>p</i> = 0.001). The bACT group showed delayed but significant improvement in anxiety at follow-up (<i>p</i> &gt; 0.001), but not in depression. Between-group comparisons revealed superior outcomes for iACT over bACT in both anxiety and depression post-intervention, though the difference in anxiety diminished by follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Internet-based ACT was more effective than bACT or standard care in reducing anxiety and depression in breast cancer patients. These results support the broader use of guided Internet-based ACT interventions in oncology settings.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Iranian Registry of Clinical Trials: IRCT20231209060301N1</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7802902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Women’s Awareness and Perceptions of Cervical and Breast Cancer in Windhoek, Khomas Region","authors":"Likius T. Hailaula,&nbsp;Albertina M. N. Shatri","doi":"10.1155/ecc/9852005","DOIUrl":"https://doi.org/10.1155/ecc/9852005","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast and cervical cancers are the most prevalent cancers among women in Namibia, with a prevalence of 28.9% and 18.3%, respectively, in 2020. However, the knowledge and attitudes of Namibian women toward breast and cervical cancers are not documented, as this is essential for early detection and improved treatment outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study explored the knowledge and attitudes regarding these cancers among women aged 18 and above in Windhoek, Khomas Region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A mixed-methods cross-sectional random sampling study was conducted from November 2024 to March 2025 across all eight constituencies of Windhoek. A questionnaire was used to document demographic information, knowledge, and awareness of breast and cervical cancer, cancer screening habits, and barriers to screening. Multivariable logistic regression was used for data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 232 females participated in the study, of which 93.5% and 95.3% reported having heard of breast and cervical cancer, respectively. Among those who were aware, 35.3% underwent breast cancer screening, while 34.5% had been screened for cervical cancer. Knowledge regarding the causes, symptoms, and prevention of both cancers was moderate to high. Education level was a significant predictor of awareness and screening behavior. Women with tertiary education (73.7%) were four times more likely to have heard of breast cancer (OR = 4.0; 95% CI: 2.8–5.7; <i>p</i> &lt; 0.001) and twice as likely to have heard of cervical cancer (OR = 2.0; 95% CI: 1.5–2.7; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Public awareness campaigns regarding early screening are crucial to improve awareness and knowledge regarding breast and cervical cancers among Namibian women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9852005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Validation of the Breast Cancer and Lymphedema Symptom Experience Index (BCLE-SEI) in Marathi","authors":"Vincent Singh Paramanandam,&nbsp;Elizabeth Dylke,&nbsp;Mei R. Fu,&nbsp;Anuradha Daptardar,&nbsp;Ajeeta Kulkarni,&nbsp;Manali Kamat,&nbsp;Sarika Mahajan,&nbsp;Sharon Kilbreath","doi":"10.1155/ecc/2099855","DOIUrl":"https://doi.org/10.1155/ecc/2099855","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A common side effect of breast cancer treatment is breast cancer–related lymphedema (BCRL), which is associated with many symptoms, such as swelling, heaviness, tightness, pain, discomfort and poor quality of life. The breast cancer and lymphedema symptom experience index (BCLE-SEI) captures the presence of BCRL-related symptoms and distress. However, the BCLE-SEI is not available in Marathi, one of the most commonly spoken Indian languages. The purpose of this study was to translate and validate the BCLE-SEI in Marathi.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>The BCLE-SEI was forward- and backward-translated, and the consolidated back translation was checked for equivalence following established guidelines. The BCLE-SEI-Marathi was then validated among 169 Marathi-speaking women with or at risk of developing BCRL. Content validity, structural validity, internal consistency, test–retest reliability, construct validity (through hypothesis testing) and known group validity were tested. Three different thresholds were used when testing known group validity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Content validity of the BCLE-SEI-Marathi was confirmed by 98% of the participants. Exploratory factor analysis identified two factors in the symptom occurrence subscale and three factors in the symptom distress subscale, which explained 49% and 53.8% of the total sample variance, respectively. Internal consistency of dimensions (factors) ranged from <i>α</i> = 0.82 to 0.94. Construct validity was established through hypothesis testing. The test–retest reliability was strong (Spearman’s rho of 0.88 (<i>p</i> &lt; 0.01, 95% CI: 0.8–0.9)). The BCLE-SEI total score was able to distinguish the participants with BCRL from those at risk for BCRL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrated that the BCLE-SEI-Marathi questionnaire is a valid and reliable tool to assess the occurrence and distress of symptoms in Marathi-speaking women with or at risk of BCRL.</p>\u0000 \u0000 <p><b>Trail Registration:</b> Clinical Trials Registry India: CTRI/2017/11/010326</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/2099855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Assessment of Neutrophil/Lymphocyte Ratio and CRP Value Correlation with Infections in Cancer Patients","authors":"Mehmet Ali Tüz,&nbsp;Hande Aydemir,&nbsp;Güven Çelebi,&nbsp;Nihal Pişkin,&nbsp;Hüseyin Engin,&nbsp;Mustafa Çağatay Büyükuysal","doi":"10.1155/ecc/9329789","DOIUrl":"https://doi.org/10.1155/ecc/9329789","url":null,"abstract":"<p>Recent studies have pointed out that CRP and NLR levels are important in determining the prognosis for cancer and diagnosis of infection, but there are few studies on cut-off levels in patients with solid tumours. In this study, the relationship between CRP cut-off levels with infection and NLR with infection has investigated in adult solid organ cancer patients receiving inpatient treatment. Patients with solid cancer hospitalised in ZBEU Oncology and Infectious Diseases between 2013 and 2018 were included to study retrospectively. Patients were separated into 2 groups: 240 patients with clinical and radiological or microbiological evidence of infection as group 1 and 240 patients with no signs of infection as group 2. Both groups were subdivided into patients with metastatic cancer and nonmetastatic cancer. The mean CRP at admission and 24th hour in the group 1 (170.0 and 157.5 mg/L, respectively) were found to be statistically higher than group 2 (51.0 and 47.5 mg/L, respectively) (<i>p</i> &lt; 0.001 and <i>p</i> &lt; 0.001). The best cut-off value of CRP at admission was found to be 108 mg/L with %72.08 sensitivity, %75.42 specificity (<i>p</i> &lt; 0.001) and 88 mg/L 24th hour CRP (<i>p</i> &lt; 0.001). Mean values of NLR on admission and 24th hour were significantly higher in group 1 than in group 2 (<i>p</i> &lt; 0.001 and <i>p</i> &lt; 0.001). The best NLR cut-off value was found to be 7.823 at admission (<i>p</i> &lt; 0.001) and 8.4 at 24th hours (<i>p</i> &lt; 0.001). Although both tests are used to detect infection in patients with solid cancer, it is important to know that the cut-off values are high. In patients with solid cancer who do not have clinical signs of infection, unnecessary antibiotherapy should not be performed because of high CRP or NLR.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2026 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9329789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146224093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}