European Journal of Cancer Care最新文献

{"title":"Predicting Family Intimacy in Cancer Patients Using Interpretable Machine Learning: Emphasizing Resilience and Self-Esteem","authors":"Wen Li,&nbsp;Jingcheng Wen,&nbsp;Nuo Zhang,&nbsp;Ting Li,&nbsp;Hongli Li,&nbsp;Yawen Zhang,&nbsp;Jie Zhang,&nbsp;Yuhan Lu,&nbsp;Dong Pang,&nbsp;Hong Yang","doi":"10.1155/ecc/9070051","DOIUrl":"https://doi.org/10.1155/ecc/9070051","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to construct interpretable machine learning models to predict family intimacy in cancer patients and identify the most influential predictors through SHAP-based analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 259 cancer patients were surveyed. The data cleaning process involved handling missing values, normalizing continuous variables, and applying one-hot encoding to categorical variables. Statistically significant sociodemographic variables (age, marital status, education, and income) and psychosocial attributes (self-esteem and three resilience subdimensions: tenacity, strength, and optimism) were selected using LASSO regression. Four regression models—gradient boosting (GB), random forest (RF), XGBoost (XGB), and decision tree (DT)—were trained and evaluated using <i>R</i>², mean-squared error (MSE), and mean absolute percentage error (MAPE).SHapley Additive exPlanations (SHAP) was used to interpret the GB model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The GB model achieved the best predictive performance (<i>R</i>² = 0.6985, MSE = 0.2405), followed by XGB (<i>R</i>² = 0.6794), RF (<i>R</i>² = 0.6653), and DT (<i>R</i>² = 0.5912). SHAP analysis revealed that psychological variables—tenacity, strength, and self-esteem—were the most influential predictors, all exerting strong positive effects. Age group and education showed moderate impact, while income, gender, and marital status contributed minimally.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gradient boosting offers a robust and interpretable framework for predicting family intimacy in cancer patients. Positive psychological resources—especially resilience and self-esteem—outperform traditional demographics as a predictive foundation, highlighting their clinical significance in survivorship care planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9070051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Status of Women Diagnosed With Breast Cancer","authors":"Heba M. Zahid,&nbsp;Walaa A. Mumena,&nbsp;Lujain Y. Alqulayti,&nbsp;Manar M. Alharbi,&nbsp;Maram S. Alzahrani,&nbsp;Raghad A. Alansari,&nbsp;Maram S. Albadi","doi":"10.1155/ecc/5500161","DOIUrl":"https://doi.org/10.1155/ecc/5500161","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>Breast cancer patients are at high risk of malnourishment. However, data concerning the nutritional status of breast cancer patients are very limited. We aimed to assess the nutritional status and diet of women diagnosed with breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 32 women diagnosed with breast cancer were included in this cross-sectional study. Patients were recruited via an online survey that was distributed in multiple social media applications as well as shared in oncology clinics. Demographic data were collected via the online survey, while dietary data were collected during a phone interview.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prevalence of overweight and obesity among study samples was 18.8% and 56.3%, respectively. Only 18.8% of the patients reported visiting a dietitian, while 59.4% of the patients met the recommendation of free sugar intake of &lt; 5%. Most of the patients (81%) did not meet their energy requirements, whereas none of the patients met their protein requirement. Diet quality score and dietary intake were not associated with dietitian visit or stages of breast cancer. Stepwise regression analysis indicated significant association between iron intake and weight status (<i>B</i> = −1.56, SE = 0.69, and [95% confidence interval (CI): −2.97–−0.15]). Results also indicated that age and percentage of free sugar from total energy predicted BMI of patients (age: <i>B</i> = 0.20, SE = 0.08, and [95% CI: 0.06–035]; percent of free sugar: <i>B</i> = 0.66, SE = 0.24, and [95% CI: 0.18–1.15]). Weight status was significantly associated with adequacy of energy intake.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>High prevalence of overweight and obesity, high intake of free sugar, and limited intake of protein were observed among women diagnosed with breast cancer. There is an urgent need to provide nutritional care for breast cancer patients in Saudi Arabia that is delivered by experienced dietitian to improve the nutritional status of these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5500161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Postoperative Medium-Chain Triglyceride Diet Management in Lung Cancer Patients: A Randomized Controlled Trial","authors":"Xiao Jia,&nbsp;Zhigang Liang,&nbsp;Dini Cao,&nbsp;Longfei Wang","doi":"10.1155/ecc/1145553","DOIUrl":"https://doi.org/10.1155/ecc/1145553","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Lung cancer surgery can lead to postoperative complications such as pleural effusion and chylothorax. This study aims to investigate the impact of a medium-chain triglyceride (MCT) diet on recovery and complications in lung cancer patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This randomized controlled trial enrolled lung cancer patients at the Ningbo University First Affiliated Hospital between February 2022 and December 2023. Participants were randomly assigned to either the MCT group or the routine diet group. The MCT group received an MCT diet from the first to the third day postoperatively and resumed a normal diet thereafter. The RD group received a staple regular diet with no restrictions. The primary outcome was chylothorax incidence within 72 h. The secondary outcomes included the pleural effusion volume, protein, triglycerides, and mononuclear cells in pleural effusion at 24 h and 48 h postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 127 patients (46 males) were enrolled, with 57 (mean age 54.91 ± 11.21 years, 21 males) receiving MCT and 70 (mean age 56.54 ± 11.84 years, 25 males) receiving RD. No chylothorax cases were observed in either group at 72 h. At 48 h, the MCT group had significantly lower pleural effusion volume (123.07 vs. 166.79 mL, <i>p</i> = 0.006), protein concentration (33.64 vs. 36.34 g/L, <i>p</i> = 0.007), and triglyceride levels (0.43 vs. 0.63 mmol/L, <i>p</i> = 0.001) compared to the RD group. No significant differences were observed in mononuclear cell counts between the two groups, but significant differences in mononuclear cell counts (<i>p</i> = 0.04) were observed at 24 h and 48 h in the MCT group, while no significant differences were observed in the RD group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MCT diet reduced protein and triglyceride levels in pleural fluid and decreased pleural effusion volume after 48 h. While no cases of chylothorax were noted, MCT dietary modifications may enhance postoperative recovery in lung cancer patients.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Chinese Clinical Trial Registry: ChiCTR2400089381</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/1145553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehabilitation in Oesophageal Cancer Care: A Qualitative Study of What Moves Patients","authors":"Elja A. E. Reijneveld,&nbsp;Jaap J. Dronkers,&nbsp;Carin D. Schröder,&nbsp;Miranda J. Velthuis,&nbsp;Jelle P. Ruurda,&nbsp;Cindy Veenhof,&nbsp; PRIOR Study Group","doi":"10.1155/ecc/7979383","DOIUrl":"https://doi.org/10.1155/ecc/7979383","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Personalised interventions are recommended to optimise participation in prehabilitation programmes, but this requires insight into what motivates patients to participate in, and complete, such programmes. We investigated the experiences of patients with oesophageal cancer who had participated in a prehabilitation programme, with a view to identifying factors that contribute to programme participation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicentre, qualitative study included patients who had completed a curative trajectory of neoadjuvant chemoradiotherapy and surgery for oesophageal cancer and who had been offered a multimodal prehabilitation programme in the period between chemoradiotherapy and surgery. Prehabilitation consisted of nutritional support and a supervised physical training programme. Data were collected after surgery using semi-structured interviews. Data were analysed using an inductive thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve patients were interviewed. Main themes contributing to programme participation were ‘development of internal motivation’, ‘external motivation through relational support’ and ‘programme feasibility and perceived benefits’. Factors related to internal motivation were ‘a clear purpose (to get through surgery)’, ‘patients’ sense of responsibility for treatment success’ and ‘a positive change of mind during the programme’. Factors related to external motivation included ‘support and supervision from healthcare providers’ and ‘support from family members’. The programme was feasible, but patients differed in their preferred level of dietary support and training supervision. Overall, the patients were positive about the programme, feeling that it prepared them for surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study shows that patients with oesophageal cancer are motivated by internal and external factors to participate in a multimodal prehabilitation programme. Clear information on the purpose of the programme, tailored supervision by healthcare providers and active involvement of family members support this feasible form of prehabilitation care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7979383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Malignant Neoplasms on Oral Health–Related Quality of Life in Paediatric and Adolescent Populations: A Systematic Review","authors":"Mariana Massuda,&nbsp;Gustavo Galvão,&nbsp;Marcelo Bonecker,&nbsp;Marina Gallottini,&nbsp;Janaína B. Medina,&nbsp;Juliana Bertoldi Franco,&nbsp;Marcela Baraúna Magno,&nbsp;Karem L. Ortega,&nbsp;Jefferson R. Tenório","doi":"10.1155/ecc/3582565","DOIUrl":"https://doi.org/10.1155/ecc/3582565","url":null,"abstract":"<p>Malignant neoplasms of any anatomical site, along with their treatments, can significantly affect the oral health of paediatric and adolescent populations, potentially influencing their oral health–related quality of life (OHRQoL). This systematic review sought to evaluate how cancer, regardless of tumour location, impacts the OHRQoL of children and adolescents. Electronic searches were conducted in PubMed, Scopus, EMBASE, Web of Science and LILACS, as well as grey literature, up to October 2023. Clinical studies reporting on OHRQoL in patients aged 0–19 years with cancer were included. Two reviewers independently performed study selection, data extraction and risk of bias assessment using the Joanna Briggs Institute tools. Certainty of evidence was evaluated using the GRADE approach. Of 27,684 records, four studies (three cross-sectional and one randomised clinical trial) met the inclusion criteria, encompassing 253 paediatric patients. OHRQoL was assessed using OHIP-14 and ECOHIS instruments. Most studies reported a weak impact of oral health on quality of life. However, methodological limitations and very low certainty of evidence were identified. Although a weak impact of oral health on quality of life was observed among children and adolescents with malignant neoplasms, the limited number and quality of available studies prevent firm conclusions. High-quality research with robust methodology is needed to better understand this relationship and draw robust conclusions and guide clinical decision-making.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3582565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145824736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decisional Conflict Regarding Perioperative Oral Nutritional Supplementation in Gastric Cancer Patients Based on a Random Forest Model: A Cross-Sectional Study","authors":"Ni Yang,&nbsp;Yuan Xu,&nbsp;Shuli Guo,&nbsp;Haiyan Hou,&nbsp;Ying Liu,&nbsp;Ge Liu,&nbsp;Xinyi Zhou,&nbsp;Yufen Ma","doi":"10.1155/ecc/4179990","DOIUrl":"https://doi.org/10.1155/ecc/4179990","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Identifying patients’ decisional conflict and its predictors is essential since it is a critical step before developing a patient decision aid for gastric cancer patients to promote decision-making in perioperative oral nutritional supplementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the current status of decisional conflict and its relationship with decision preparation and decision participation regarding perioperative oral nutritional supplementation in gastric cancer patients and to explore the predictors of decisional conflict.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A convenience sampling method was employed to recruit inpatients undergoing radical gastrectomy for gastric cancer, and self-reported questionnaires were used to collect data. The Random Forest model, least absolute shrinkage and selection operator regression, and multivariate stepwise linear regression analysis were employed for data analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 181 patients with gastric cancer were investigated. 42.5% of them had no decisional conflict, and 57.5% of them had decisional conflict. 71.3% of them expressed a desire to engage in shared decision-making, but only 29.3% of them actually participated in it. The actual type of decision-making and knowledge about oral nutritional supplementation were predictors of decisional conflict.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Over half of the gastric cancer patients experienced decisional conflict regarding oral nutritional supplementation during the perioperative period. The actual type of decision-making and knowledge about oral nutritional supplementation among gastric cancer patients are two predictors for decisional conflict. Healthcare professionals should consider the two predictors when developing a patient decision aid to provide decision support.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/4179990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience and Perceptions With a Phone-Based Weight Loss Intervention Among Overweight and Obese Survivors of Breast Cancer Enduring Cancer-Related Fatigue in France: A Qualitative Study Within a Randomized Clinical Trial","authors":"Elise Martin,&nbsp;Antonio Di Meglio,&nbsp;Stefano Maccarone,&nbsp;Barbara Pistilli,&nbsp;Laurence Vanlemmens,&nbsp;Carine Segura-Djezzar,&nbsp;Carole Bouleuc,&nbsp;Olivier Tredan,&nbsp;Tracy E. Crane,&nbsp;Davide Soldato,&nbsp;Cécile Charles,&nbsp;Aude Barbier,&nbsp;Bruno Raynard,&nbsp;Anthony Mangin,&nbsp;Bernadette Coquet,&nbsp;Guillemette Jacob,&nbsp;Julia Bonastre,&nbsp;Stefan Michiels,&nbsp;Dan Chaltiel,&nbsp;Fabrice André,&nbsp;Jennifer Ligibel,&nbsp;Ines Vaz-Luis,&nbsp;Maria Alice Franzoi","doi":"10.1155/ecc/5589906","DOIUrl":"https://doi.org/10.1155/ecc/5589906","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The MEDEA randomized clinical trial evaluated the impact of a telephone-based weight loss intervention focused on calorie restriction and lifestyle behavior change among overweight and obese breast cancer (BC) patients on cancer-related fatigue in France. The intervention was linguistically and culturally adapted from the North American BWEL-A011401. Since patient acceptability and engagement with weight loss interventions are influenced by cross-country cultural differences in dietary, social, and behavioral habits, we conducted a qualitative study to explore these factors and inform future implementation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among 220 patients with Stage I–III BC who participated in MEDEA, 110 were randomized to receive the weight loss intervention delivered by dietitians through 24 semistructured calls over 12 months. Twenty patients receiving the intervention accepted participation in four focus groups to explore barriers and facilitators for uptake and engagement, as well as acceptability, satisfaction, and improvement suggestions. A thematic content analysis was performed using Nvivo12 software.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Four focus groups were conducted. Overall, patients generally expressed positive perceptions of the intervention, highlighting several key themes: (1) satisfaction with the intervention, reporting objective benefits, including measurable weight loss and reduced symptom burden; (2) recognition of intervention as a catalyst for sustainable behavioral change; and (3) appreciation for the convenience of a telephone-based format. However, participants also identified several barriers to uptake and engagement, along with suggestions for improvement: (1) The need for tools to sustain engagement such as postintervention follow-up calls, psychological support, and resources for self-monitoring; (2) for the importance of further cultural adaptation; and (3) a call for a more patient-centered research ecosystem, encompassing the selection of relevant patient-reported outcomes, improved communication, and enhanced community-building efforts).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The MEDEA intervention was found to be acceptable and positively experienced, suggesting that a North American weight loss program seems adaptable to a different language and cultural context. This qualitative analysis also informed refinements to optimize weight loss interventions in a European context.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 ","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5589906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Copper Level Correlates With Body Mass Index–Adjusted Body Weight Loss Grades and Total Fat Mass in Male Patients With Recurrent or Metastatic Head and Neck and Nasopharyngeal Cancers","authors":"Chun-Feng Wu,&nbsp;Pei-Hung Chang,&nbsp;Hang Huong Ling,&nbsp;Yi-Ping Pan,&nbsp;Yu-Ching Lin,&nbsp;Wen-Chi Chou,&nbsp;Chia-Lin Peng,&nbsp;Zih-Syuan Chen,&nbsp;Simon Hsia,&nbsp;Kun-Yun Yeh","doi":"10.1155/ecc/5986221","DOIUrl":"https://doi.org/10.1155/ecc/5986221","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>There is a lack of comprehensive analysis on the associations between malnutrition, body composition, and clinical, anthropometric, biochemical, nutrition-inflammation markers, mineral and trace element levels, cytokine concentrations, and antioxidant activity in patients with cancer. Differences regarding sex at birth, ethnicity, and cancer types and stages further contribute to variations in body composition and mineral and trace element levels. This study examines factors associated with malnutrition and body composition, adjusting for relevant clinical, biochemical, nutritional data, and lifestyle confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In total, 78 male patients with recurrent or metastatic head and neck cancer (HNC) or nasopharyngeal carcinoma (NPC) were recruited. Clinical characteristics (e.g., age, tumor status, and performance status), lifestyle factors, anthropometric data, nutrition-inflammation markers, plasma levels of minerals, trace elements, and cytokines as well as antioxidant activity were determined and analyzed using multivariable logistic regression and analysis of covariance models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Half of the patients (50.3%) exhibited advanced grades of BMI-adjusted body weight loss (BWL), and nearly 90% had C-reactive protein levels exceeding 5 mg/L, reflecting poor nutritional status and elevated inflammation, despite being medically fit for chemotherapy. Plasma copper levels were independently associated with BMI-adjusted BWL as well as with lean body mass and total fat mass. Similarly, plasma zinc levels showed an independent association with total fat mass.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Plasma levels of trace elements, including copper and zinc, are strongly correlated with malnutrition and body composition in male patients with recurrent or metastatic HNC or NPC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5986221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Psychodynamic Psychotherapy in Serious Physical Illness: Systematic Review and Meta-Analysis","authors":"Rebecca Philipp,&nbsp;Charlotte Walbaum,&nbsp;Carsten Bokemeyer,&nbsp;Martin Härter,&nbsp;Karin Oechsle,&nbsp;Sigrun Vehling","doi":"10.1155/ecc/4791709","DOIUrl":"https://doi.org/10.1155/ecc/4791709","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Prevalence rates of depression and anxiety in patients with a serious physical illness are high. Psychodynamic psychotherapies show potential in mitigating such psychological distress because they address hindering relational experiences and unconscious conflicts that may impair patients’ capacity to cope with illness-related distress. We investigated the efficacy of psychodynamic psychotherapy for symptoms of depression and anxiety in patients with serious physical illness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic literature search to identify randomized controlled trials and quasi-experiments of psychodynamic psychotherapies in adults with serious physical illness. We conducted random-effects meta-analyses and narrative summaries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 15,112 records and included 5 RCTs (<i>n</i> = 648, mean age: 52.4 years, 69% female). Meta-analyses showed no significant differences between psychodynamic and standard treatment for the reduction of depressive symptoms in serious physical illness (SMD = −0.24, 95% CI: −0.87 to 0.39). No meta-analysis was calculated for anxiety symptoms due to the small number of studies investigating this outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Quantitative evidence for the efficacy of psychodynamic psychotherapy in this population is inconclusive. More research is needed with regard to effective intervention length and adequate outcome measures, especially in patients with incurable illness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/4791709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Utility of ChatGPT-4o and DeepSeek-R1 for Multidisciplinary Uro-Oncology Tumor Boards: A Tumor Type–Specific Analysis","authors":"Ertugrul Cakir,&nbsp;Tumay Bekci,&nbsp;Serdar Aslan,&nbsp;Ural Oguz,&nbsp;Ercan Ogreden,&nbsp;Erhan Demirelli,&nbsp;Dogan Sabri Tok,&nbsp;Birgul Tok,&nbsp;Sendag Yaslikaya,&nbsp;Sevket Zorlu,&nbsp;Yahya Han Memis","doi":"10.1155/ecc/9029196","DOIUrl":"https://doi.org/10.1155/ecc/9029196","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study demonstrates the potential benefits of large language models (LLMs) such as ChatGPT-4o and DeepSeek-R1 in supporting multidisciplinary uro-oncologic tumor boards (MUTBs) discussing complex urological-oncological cases. In particular, DeepSeek-R1 has demonstrated better performance than ChatGPT-4o in specific types of urological malignancies and specific treatment protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study examined the agreement between the AI-based systems ChatGPT-4o and DeepSeek-R1 and the decision making of a MUTB, which is a team of experts who assess uro-oncological cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 97 uro-oncological cases covering a period of one year were retrospectively evaluated. The treatment plans for the cases were determined using traditional tumor board methods and separately presented to ChatGPT-4o and DeepSeek-R1. Comprehensive medical records were created for each case, and the planned treatments were classified as surgical intervention, radiotherapy/chemotherapy (RT-CT), advanced imaging, or follow-up. Agreement between the board and AI decisions was analyzed using Cohen’s kappa and with precision, recall, and F1 scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In prostate cancer cases, DeepSeek-R1 showed substantial agreement (<i>κ</i> = 0.787, <i>p</i> &lt; 0.001) with the board decisions, while ChatGPT-4o showed moderate agreement (<i>κ</i> = 0.593, <i>p</i> &lt; 0.001). For renal malignancies, DeepSeek-R1 showed moderate agreement (<i>κ</i> = 0.603,<i>p</i> &lt; 0.001), while ChatGPT-4o showed slight agreement (<i>κ</i> = 0.172, <i>p</i> &lt; 0.001). In bladder cancer cases, DeepSeek-R1 showed moderate agreement (<i>κ</i> = 0.604, <i>p</i> &lt; 0.05), but ChatGPT-4o did not show statistically significant agreement (<i>κ</i> = 0.217, <i>p</i> &gt; 0.05). When all cases were considered together, DeepSeek-R1 showed high agreement, while ChatGPT-4o showed moderate agreement (DeepSeek-R1: <i>κ</i> = 0.773, <i>p</i> &lt; 0.001; ChatGPT-4o: <i>κ</i> = 0.608, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that DeepSeek-R1’s decision support performance is better than that of ChatGPT-4o in various oncological scenarios. The results highlight the potential for publicly available AI models to be used in complex clinical fields, such as oncology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9029196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}