European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Ionized calcium and PTH as predictors of hypoparathyroidism following total thyroidectomy.","authors":"Mario Sánchez-Canteli, María Pasarón-Canga, María Riestra-Fermández, Gala Gutiérrez-Buey, Patricia Martínez-González, Raquel Fernández-Morais, Marta Elena Fernández-Pello, Juan Carlos Álvarez-Méndez","doi":"10.1007/s00405-025-09205-2","DOIUrl":"10.1007/s00405-025-09205-2","url":null,"abstract":"<p><strong>Purpose: </strong>Post-surgical hypoparathyroidism (POSH) is a common complication after total thyroidectomy. This study aims to assess the accuracy of serum and ionized calcium and PTH levels on the first postoperative day (POD-1) to predict postoperative hypocalcemia (PoHC), transient hypoparathyroidism (THPT), and permanent hypoparathyroidism (PtHPT).</p><p><strong>Methods: </strong>Biochemical parameters and clinical variables were retrospectively analyzed in 200 patients. The optimal cut-off points were determined using ROC curve analysis. Results were correlated with analytical and clinical variables and patient outcomes.</p><p><strong>Results: </strong>PoHC incidence in POD-1 was 46%; THPT and PtHPT were 37 and 9%, respectively. Ionized calcium < 4.43 mg/dL on POD-1 predicted PoHC (AUC = 0.9) better than PTH and serum calcium. PTH < 8.06 pg/mL on POD-1 predicted PtHPT (AUC = 0.797). Multivariate analysis identified PTH < 21.2 pg/mL, ionized calcium < 4.43 mg/dL, and serum calcium < 8.76 mg/dL on POD-1 as significant PoHC risk factors.</p><p><strong>Conclusion: </strong>Ionized calcium on POD-1 predicts PoHC accurately, while serum PTH indicates higher risk for PtHPT.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3163-3171"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the incidence and burden of otitis media in children: a global analysis from 1990 to 2021.","authors":"Lingkang Dong, Yuchen Jin, Wenqi Dong, Yumeng Jiang, Zhuangzhuang Li, Kaiming Su, Dongzhen Yu","doi":"10.1007/s00405-024-09165-z","DOIUrl":"10.1007/s00405-024-09165-z","url":null,"abstract":"<p><strong>Background: </strong>Otitis media (OM) is a prevalent and serious condition in childhood, but comprehensive global studies assessing its burden are lacking.</p><p><strong>Methods: </strong>Using data from the 2021 Global Burden of Disease (GBD) study, we analyzed OM incidence cases and disability-adjusted life years (DALYs) in children aged 0-14 from 1990 to 2021. Trends were analyzed across regions, age groups, sexes, and socio-demographic index (SDI) using estimated annual percentage changes (EAPC). Predictive models were used to forecast trends to 2050.</p><p><strong>Results: </strong>The global number of OM incidence cases in children increased from 256 million in 1990 to 297 million in 2021, a 15.97% rise. The age-standardized incidence rate (ASIR) showed a slight increase (EAPC: 0.12). Despite some variations across age, sex, and regions, the age-standardized DALY rate (ASDR) declined. ASIR and ASDR were highest in children aged < 1 year and gradually decreased with age. The largest burden was observed in low- and middle-low-SDI regions, although these regions showed the greatest declines in EAPC. Correlation analysis indicated that ASDR decreases as the SDI increases. By 2050, the number of global OM incidence cases in children is projected to reach 334 million, with most of the increase concentrated in low-SDI regions, while ASIR is expected to remain stable.</p><p><strong>Conclusion: </strong>Although progress has been made in controlling OM in children over the past 30 years, the ASIR remains high. The sustained high burden and incidence of OM in low-SDI regions, and among young children, pose a significant challenge to children's health.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2959-2970"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of transcutaneous electrical nerve stimulation in alleviation of tinnitus in normal hearing subjects.","authors":"Maha Abdelgaber A Aly, Enas Mostafa O Ramadan, Amira Mohammad Eloseily","doi":"10.1007/s00405-024-09182-y","DOIUrl":"10.1007/s00405-024-09182-y","url":null,"abstract":"<p><strong>Background: </strong>Subjective tinnitus is characterized by perception of sound in the absence of any external or internal acoustic stimuli. Many approaches have been developed over the years to treat tinnitus (medical and nonmedical). However, no consensus has been reached on the optimal therapeutic approach. Electrical nerve stimulation targeting peripheral auditory pathways presents a promising area of investigation for the treatment of tinnitus. Non-invasive transcutaneous vagal nerve stimulation of the auricular branch of the vagus nerve has been introduced and studied but its success rate varies and conflicting results have been reported. In this study we aim to assess the role of transcutaneous electrical nerve stimulation in alleviation of tinnitus in normal hearing subjects and to study the different factors that may affect the degree of alleviation of tinnitus.</p><p><strong>Methods: </strong>The study group consisted of 64 subjects (38 male and 26 female). The age ranged between 20 and 60 years. All of them suffering from subjective tinnitus. Assessment of tinnitus loudness analyzed by Visual Analogue Scale (VAS) which was applied before and directly after TENS stimulation.</p><p><strong>Results: </strong>There is a statistically significant difference in tinnitus loudness before and after TEN stimulation as assessed by VAS. 45 out of 64 (70.31%) patients had improvement after TENS, from them nine patients had a complete reduction of tinnitus. There is no statistically significant relation between the studied variables and the degree of tinnitus reduction.</p><p><strong>Conclusion: </strong>ta-VNS is an effective treatment of subjective tinnitus but we could not assess for how long this residual inhibition persists due to lack of long term follow up. However, it is difficult to decide who might benefit from ta-VNS, patients with unilateral tinnitus on right ear and those with whistling sound have more reduction in tinnitus loudness than others.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2983-2990"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any room for ChatGPT AI bot in speech-language pathology?","authors":"Namık Yücel Birol, Hilal Berber Çiftci, Ayşegül Yılmaz, Ayhan Çağlayan, Ferhat Alkan","doi":"10.1007/s00405-025-09295-y","DOIUrl":"10.1007/s00405-025-09295-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the potential of the ChatGPT-4.0 artificial intelligence bot to assist speech-language pathologists (SLPs) by assessing its accuracy, comprehensiveness, and relevance in various tasks related to speech, language, and swallowing disorders.</p><p><strong>Method: </strong>In this cross-sectional descriptive study, 15 practicing SLPs evaluated ChatGPT-4.0's responses to task-specific queries across six core areas: report writing, assessment material generation, clinical decision support, therapy stimulus generation, therapy planning, and client/family training material generation. English prompts were created in seven areas: speech sound disorders, motor speech disorders, aphasia, stuttering, childhood language disorders, voice disorders, and swallowing disorders. These prompts were entered into ChatGPT-4.0, and its responses were evaluated. Using a three-point Likert-type scale, participants rated each response for accuracy, relevance, and comprehensiveness based on clinical expectations and their professional judgment.</p><p><strong>Results: </strong>The study revealed that ChatGPT-4.0 performed with predominantly high accuracy, comprehensiveness, and relevance in tasks related to speech and language disorders. High accuracy, comprehensiveness, and relevance levels were observed in report writing, clinical decision support, and creating education material. However, tasks such as creating therapy stimuli and therapy planning showed more variation with medium and high accuracy levels.</p><p><strong>Conclusions: </strong>ChatGPT-4.0 shows promise in assisting SLPs with various professional tasks, particularly report writing, clinical decision support, and education material creation. However, further research is needed to address its limitations in therapy stimulus generation and therapy planning to improve its usability in clinical practice. Integrating AI technologies such as ChatGPT could improve the efficiency and effectiveness of therapeutic processes in speech-language pathology.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3267-3280"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preadmission systemic antibiotic treatment in necrotizing otitis externa (NOE).","authors":"Sharifah Sara Syed Badrol, Oren Ziv, Chilaf Peled","doi":"10.1007/s00405-024-09161-3","DOIUrl":"10.1007/s00405-024-09161-3","url":null,"abstract":"<p><strong>Purpose: </strong>Necrotizing otitis externa (NOE) is a serious life-threatening infection, with Pseudomonas (PA) aeruginosa being the primary causative agent. Over the last two decades the use of systemic anti-PA antibiotics expanded substantially and are now prescribed regularly by physicians. Meanwhile, studies indicate shifting trends in the incidence of the offending pathogen in NOE. The objective of the study is to assess whether preadmission antibiotic treatment influence the incidence offending pathogens and sterile cultures in NOE. Also, we aim to evaluate the effects of preadmission antibiotic treatment on NOE severity and disease progression.</p><p><strong>Methods: </strong>A retrospective case series analysis was performed, including all patients admitted in a single tertiary center due to NOE.</p><p><strong>Results: </strong>83 patients were included in the study. Among them 17 patients received no oral antibiotics prior to admission (NoAb-NOE), and 65 patients received systemic antibiotics prior to admission. There was no statistical difference between the groups regarding the incidence of the pathogen or sterile culture. Furthermore, there was no statistical difference regarding duration of hospitalization, need for surgery or readmission.</p><p><strong>Conclusion: </strong>Preadmission antibiotic treatment does not influence the incidence of offending pathogens or rate of sterile culture in NOE. Moreso, preadmission antibiotic has no effect on disease progression or severity in NOE. Our findings suggest that sterile culture NOE is probably due to the low sensitivity of superficial swabs and not secondary to partially treated disease. Deep tissue culture should be considered in the setting of NOE patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2921-2925"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of dupilumab in CRSwNP: unaffected by baseline nasal polyp size in real-world settings.","authors":"Michael Habenbacher, Ulrich Moser, Ahmed Abaira, Peter Kiss, Clemens Holzmeister, Jakob Pock, Katharina Walla, Angelika Lang, Alexandros Andrianakis","doi":"10.1007/s00405-025-09275-2","DOIUrl":"10.1007/s00405-025-09275-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the impact of baseline nasal polyp score (NPS) on the effectiveness of dupilumab treatment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).</p><p><strong>Methods: </strong>In this retrospective observational study, 80 CRSwNP patients treated with dupilumab 300 mg biweekly at a tertiary referral center were stratified according to the baseline NPS into two groups: low-NPS (< 5) and high-NPS (≥ 5). Treatment outcomes were evaluated at the 6-month follow-up visit and compared.</p><p><strong>Results: </strong>Both groups showed significant clinical improvements. The NPS decreased significantly in both low- and high-NPS groups, from a mean score of 3.2 to 0.8 and from 6.1 to 1.4, respectively (p < 0.001 for both). SNOT-22 scores improved significantly in both groups (p < 0.001 for both), though the reduction was greater in the high-NPS group (35.5 vs. 23.9, p = 0.018). There were no significant differences between low- and high NPS groups in proportions of NPS reduction of ≥ 1 (89% vs. 95%, p = 0.396) and clinically significant SNOT-22 improvement (= reduction > 12 or follow-up SNOT < 40; 80% vs. 86%, p = 0.544).</p><p><strong>Conclusions: </strong>Our results suggests that dupilumab is effective in CRSwNP treatment, regardless of baseline nasal polyp size. Both small and large polyp groups showed significant improvements in NPS and patient-reported outcome measures. Future, prospective studies are warranted to validate these findings.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3329-3334"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct inflammatory patterns and nasal bacterial dysbiosis in uncontrolled chronic rhinosinusitis.","authors":"Yunfan Zhang, Zheng Liu, Fan Yuan, Xiaoxi Huang, Dawei Wu","doi":"10.1007/s00405-025-09376-y","DOIUrl":"10.1007/s00405-025-09376-y","url":null,"abstract":"<p><strong>Objective: </strong>The concept of disease control is increasingly gaining importance in the long-term management of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been identified as a high-risk factor for uncontrolled CRS. Although evidence suggests that dysbacteriosis is involved in the pathogenesis of eosinophilic CRS, its association with disease control has not been explored. We attempt to explore the inflammatory patterns and nasal bacterial dysbiosis among patients with uncontrolled CRS.</p><p><strong>Methods: </strong>We performed a cross-sectional study of 48 patients with uncontrolled CRS, 44 patients with controlled CRS, and 58 healthy controls. Uncontrolled CRS was defined according to European Position Paper on Rhinosinusitis and Nasal Polyps 2020. The nasal mucus and peripheral venous blood were collected for inflammatory endotype analysis. The bacterial microbiota of the swab from the middle meatus was profiled by sequencing the V3-V4 region of the 16S rRNA gene.</p><p><strong>Results: </strong>Uncontrolled CRS showed significantly higher levels of mucus eosinophil-derived neurotoxin (EDN) (P < 0.001), blood eosinophil counts (P = 0.002), blood basophil counts (P = 0.020), and blood lymphocyte counts (P = 0.033) than patients with controlled CRS. The nasal mucus EDN level was the best predictor of uncontrolled CRS, with the highest area under the receiver operating characteristic curve (AUC) of 0.798 (95% confidence interval [CI] = 0.692-0.904) compared to other inflammatory parameters. Patients with uncontrolled CRS exhibited a significant increase in the abundance of seven genera. Except for Ralstonia and Acinetobacter, the other five genera had a mean relative abundance < 1%, including Klebsiella and Pseudomonas. By random forest analysis, we established a model for the nasal microbiome with an AUC of 0.949 (95% CI = 0.903-0.996). Upon incorporating peripheral eosinophil and basophil counts into the model, we found an enhancement in diagnostic capability, with an AUC of 0.974 (95% CI = 0.944-1.000).</p><p><strong>Conclusions: </strong>Patients with uncontrolled CRS have distinct local and systematic inflammatory patterns and bacterial dysbiosis compared to both controlled CRS and healthy controls, which sheds light on the pathogenesis of uncontrolled status in CRS.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3085-3096"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comment on oral phenylephrine use in sinonasal pathologies.","authors":"Syed Ahmed Shahzaeem Hussain, Muhammad Talha, Muhammad Faizan Tariq","doi":"10.1007/s00405-025-09348-2","DOIUrl":"10.1007/s00405-025-09348-2","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3381-3383"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements and future directions in chronic rhinosinusitis: understanding inflammatory mechanisms (2000-2023).","authors":"Sheng Long, Huan Wang, Wanpeng Li, Li Hu, Huapeng Yu, Zhuofu Liu, Kun Du, Xicai Sun, Dehui Wang, Han Li","doi":"10.1007/s00405-025-09245-8","DOIUrl":"10.1007/s00405-025-09245-8","url":null,"abstract":"<p><strong>Objective: </strong>To characterize research on inflammation in CRS over the past 23 years, and analyze trends in hotspots, and collaboration networks.</p><p><strong>Methods: </strong>We conducted a methodological, objective, and extensive analysis of inflammation in CRS to track research trends and hotspots. Original research literature published between 2000 and 2023 was obtained from The Web of Science Core Collection (WoSCC) database. Data on country/region, institution, author, journal, keywords, and references were extracted using VOSviewer and CiteSpace for analysis.</p><p><strong>Results: </strong>The number of publications on inflammation in CRS has significantly increased over the past 23 years. The United States has been the most prolific contributor in terms of publications and collaborations. The top 10 high-frequency keywords were \"chronic rhinosinusitis,\" \"nasal polyps,\" \"asthma,\" \"inflammation,\" \"sinusitis,\" \"rhinosinusitis,\" \"eosinophils,\" \"nasal polyposis,\" \"chronic rhinosinusitis with nasal polyps,\" and \"allergic rhinitis.\" The timeline view revealed changes in keywords over time, with endotype and biologics emerging as recent hotspots.</p><p><strong>Conclusions: </strong>Substantial improvement has been made in the study of inflammation in CRS. The United States leads with the most published articles, productive institutions, and influential journals. Strengthening collaborations between institutions and countries is recommended. The current focus is primarily on immunotherapy, and inflammation in CRS is likely to continue being a prominent topic.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2899-2909"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the usability of grading scales for drug-induced ototoxicity with a focus on real world data collection.","authors":"Melissa Koot, Mirjam Crul, Dorieke van Balen, Tim Schutte","doi":"10.1007/s00405-025-09412-x","DOIUrl":"10.1007/s00405-025-09412-x","url":null,"abstract":"<p><strong>Purpose: </strong>Chemotherapy induced ototoxicity (e.g. by cisplatin) is a regularly occurring although underreported challenge in clinical practice. Several reviews of ototoxicity monitoring throughout clinical trials reveal difficulty in estimating the incidence due to the use of different scales and classification systems. In this communication, we introduce a scale  to improve the assessment of ototoxicity during routine cancer care incorporating patient reported outcomes.</p><p><strong>Methods: </strong>Combining and updating the existing ototoxicity scales to develop a new and universally applicable grading scale.</p><p><strong>Results: </strong>The developed scale includes all types of ototoxicity (hearing loss as well as tinnitus) and combines audiogram measurements with patient reported outcomes.</p><p><strong>Conclusion: </strong>Using a single scale for assessing and grading ototoxicity in routine care as well as in clinical trials may improve the current understanding of the actual incidence and actual patient burden of this toxicity.  In addition, it could  enhance the opportunities for intervention and/or aural rehabilitation.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3343-3347"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}