European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Teratocarcinosarcoma of the nasal cavity: challenges in the clinico-pathologic perspectives.","authors":"Mousam Maiti, Mainak Dutta, Jayati Datta, Arundhati Mukherjee, Debangshu Ghosh, Ajay Mallick","doi":"10.1007/s00405-024-09154-2","DOIUrl":"10.1007/s00405-024-09154-2","url":null,"abstract":"<p><strong>Objective: </strong>Clinicopathologic illustration of sinonasal teratocarcinosarcoma (SNTCS) in a middle-aged man, highlighting the difficulties and challenges encountered during surgical intervention, histopathologic diagnosis, and its overall management.</p><p><strong>Methodology: </strong>Case report and literature review.</p><p><strong>Results: </strong>A 40-year-old man having recurrent epistaxis for three months presented with a dark-colored protruding polypoid nasal mass. Magnetic resonance imaging revealed a large, heterogeneous gadolinium-enhanced infiltrative lesion in the left nasal cavity with a T2-hypointense trans-septal zone. The mass abutted the cribriform plate, lamina papyracea, and septum, involved the inferior and middle turbinates, and blocked the choanae through the nasopharynx. There was profuse hemorrhage when an endoscope-assisted biopsy was attempted. Histopathology from the debulked specimen suggested SNTCS. The diagnosis was confirmed on immunohistochemistry. A metastatic search turned negative. However, at three weeks, the patient returned with a recurrence. A repeat debulking was done, and he was thereafter put on adjuvant chemotherapy. A second recurrence/residual lesion was noted midway through the chemotherapy regimen. However, it resolved after completion of the chemotherapy and subsequent image-guided radiotherapy, and the patient continued to be disease-free till the last follow-up at six weeks postradiotherapy.</p><p><strong>Conclusions: </strong>SNTCS is an extremely aggressive malignancy that is seldom encountered in routine otolaryngology and pathology practice, with only a few reports of SNTCS documented. It is histologically composed of epithelial, mesenchymal, and primitive neuroectodermal elements with areas of undifferentiation. They are notorious for troublesome intra-operative bleeding, making complete surgical excision difficult, and the absence of a tumor-free margin often results in recurrence. Owing to their variegated and heterogeneous tissue composition, histopathologic diagnosis is enormously challenging without a representative tissue sample and immunohistochemistry. In spite of prompt and energetic multimodality treatment, survival rate is dismal.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2745-2751"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of positional changes in optimizing OSA treatment: evidence from DISE.","authors":"Michaela Mladoňová, Katarína Fedorová, Ondřej Jor, Jana Slonková, Adéla Kondé, Pavel Komínek, Petr Matoušek","doi":"10.1007/s00405-025-09314-y","DOIUrl":"10.1007/s00405-025-09314-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the impact of positional changes on upper airway obstruction patterns during drug-induced sleep endoscopy (DISE) in patients with obstructive sleep apnea (OSA) and identify the airway regions most responsive to this change. Special focus was placed on the tongue base, a critical area in OSA pathophysiology.</p><p><strong>Methods: </strong>This prospective study was conducted from June 2021 to June 2024. DISE was performed in patients with obstructive sleep apnea (OSA) in supine and lateral positions to simulate the effect of positional therapy. Findings were evaluated using the VOTE classification.</p><p><strong>Results: </strong>The examination was performed on 186 patients, with a median Apnea-Hypopnea Index (AHI) of 19.3. In the supine position, complete obstructions were noted at the soft palate (88.2%), oropharynx (33.3%), tongue base (53.2%), and epiglottis (15.6%). Lateral positioning significantly reduced obstructions, particularly at the tongue base, where obstruction resolved in 94/99 of cases (94.9%). This improvement was significantly more pronounced at the tongue base than at other sites (p < 0.001).</p><p><strong>Conclusion: </strong>These results suggest that DISE can identify airway regions responsive to positional changes, potentially guiding clinical decisions on positional therapy. The findings show a significant reduction in tongue base obstruction during lateral positioning in DISE. Since tongue base obstruction is a key contributor to airway collapse in OSA, this improvement suggests a practical, non-invasive treatment approach. While these findings highlight an acute association between lateral positioning and reduced obstruction, further studies are needed to evaluate its long-term clinical efficacy.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2709-2717"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-1 antitrypsin deficiency and risk of sleep apnea: a nationwide cohort study.","authors":"Lucas Møller Larsen, Sine Voss Winther, Asbjørn Kørvel-Hanquist, Sarah C W Marott, Eskild M Landt, Preben Homøe, Børge G Nordestgaard, Morten Dahl","doi":"10.1007/s00405-025-09270-7","DOIUrl":"10.1007/s00405-025-09270-7","url":null,"abstract":"<p><strong>Objectives: </strong>α₁-Antitrypsin deficiency is a disease characterized by increased neutrophil elastase activity leading to tissue getting less elastic and robust. It is known that if tissue in the pharynx becomes less elastic and robust, it could contribute to obstructive sleep apnea. This paper seeks to investigate whether patients with α₁-antitrypsin deficiency have an increased risk of sleep apnea.</p><p><strong>Methods: </strong>We tested this hypothesis by doing a nationwide cohort study of 2702 individuals diagnosed with α₁-antitrypsin deficiency compared with 26,750 individuals without α₁-antitrypsin deficiency matched on sex, age, and municipality. All individuals were followed from birth and were censored at the time of outcome, emigration, death, or end of follow-up 31st of December 2018, whichever came first.</p><p><strong>Results: </strong>Individuals with α₁-antitrypsin deficiency had a higher risk of sleep apnea with an adjusted hazard ratio of 1.81 (95% CI 1.36-2.40) compared to controls without α₁-antitrypsin deficiency. Similarly, the risk of obstructive sleep apnea was nominally higher in individuals with α₁-antitrypsin deficiency compared to controls without the disease (1.47, 95% CI 0.95-2.28). In stratified analysis, the risk of sleep apnea was higher in individuals without chronic obstructive pulmonary disease (2.33, 95% CI 1.54-3.51) (P for interaction < 0.05). The increased risk of SA was unaffected when the analysis was stratified by ischemic heart disease, ischemic cerebrovascular disease, type 2 diabetes, hypertension, and liver cirrhosis.</p><p><strong>Conclusion: </strong>Individuals with α₁-antitrypsin deficiency have a higher risk of sleep apnea in the Danish population.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2679-2686"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The differences between the subtypes of obstructive sleep apnea among different provinces in Turkey: a multicenter study.","authors":"Sidika Deniz Yalim, Nazan Bayram, Imran Ozdemir, Cemal Cingi, Nuray Bayar Muluk","doi":"10.1007/s00405-025-09271-6","DOIUrl":"10.1007/s00405-025-09271-6","url":null,"abstract":"<p><strong>Purpose: </strong>Our aim in this study is to investigate the significance and implications of different clinical subtypes of patients with obstructive sleep apnea syndrome (OSAS) in three different sleep centers from varied provinces.</p><p><strong>Methods: </strong>Between January 2023 and November 2024, 330 patients from three sleep centers (Adana, Gaziantep, and Istanbul) were retrospectively examined for age, gender, body mass index (BMI), polysomnography parameters, sleep stages, arousals, oxygen parameters, heart rates, apnea-hypopnea indexes (AHI) and snoring.</p><p><strong>Results: </strong>OSAS patients of Gaziantep were fat and severe OSAS patients who slept lightly but efficiently at lower oxygen levels with longer durations. They fell into Rapid Eye Movement (REM) sleep quickly. The number of hypopneas is high. OSAS patients of Adana sleep deeply, frequently wake after sleep onset, and snore less. The number of obstructive apnea is high. OSAS patients of Istanbul sleep efficiently but snore a lot. REM oxygen saturation, oxygen desaturation index (ODI) levels, and the average heart rate were high in Istanbul. The number of central and mixed apneas is high.</p><p><strong>Conclusions: </strong>Sleep patterns and oxygen measurements varied among clinical subtypes of patients with OSAS, as well as among provinces. Understanding regional or subtype-specific OSAS could alter practice because treatment can be planned according to the severity of OSAS.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2687-2696"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes and effectiveness of active surveillance for low-risk papillary thyroid carcinoma: a systematic review and meta-analysis.","authors":"Van Cuong Nguyen, Chang Myeon Song, Yong Bae Ji, Shinje Moon, Jung Hwan Park, Dong Sun Kim, Kyung Tae","doi":"10.1007/s00405-024-09141-7","DOIUrl":"10.1007/s00405-024-09141-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the outcomes and effectiveness of active surveillance (AS) in patients with low-risk papillary thyroid carcinoma (PTC) and compare them to those of immediate surgery (IS).</p><p><strong>Methods: </strong>A systematic review and meta-analysis, including 14 comparative studies and 7 noncomparative studies, was conducted, encompassing a total of 9,397 patients.</p><p><strong>Results: </strong>AS was associated with lower rates of familial history of thyroid cancer, multiplicity, and overall mortality compared to IS. The disease progression rate during AS was 14.53% (95% CI, 9.59-21.43%), and the delayed surgery rate was 14.91% (95% CI, 8.35-25.21%). No thyroid cancer-related mortality was observed in either the AS and IS groups. Clinicopathological characteristics showed no significant differences between delayed surgery and IS, except for higher rates of extrathyroidal extension and multiplicity in the delayed surgery group. Overall complication and recurrence rates were higher in the delayed surgery group than in the IS group. Quality of life and anxiety levels were similar between AS and IS, except for interest in sex, where AS was more beneficial.</p><p><strong>Conclusion: </strong>AS is a feasible and reliable option for managing low-risk PTC, with a relatively low rate of disease progression and no thyroid cancer-related mortality. However, AS should be undertaken with caution, given the higher rates of overall complications and recurrence in the delayed surgery group compared to the IS group. Further studies with larger sample sizes and long-term follow-up are needed to clarify the role and effectiveness of AS.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2239-2252"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of PDE5 effect on NOS in nasal polyp pathophysiology.","authors":"Vahit Mutlu, Zülküf Kaya, Zekai Halıcı, Ayşegül Tavacı Özçelik, Abdullah Serdar Topatan","doi":"10.1007/s00405-025-09362-4","DOIUrl":"10.1007/s00405-025-09362-4","url":null,"abstract":"<p><strong>Purpose: </strong>Nasal polyps are masses resulting from chronic mucosal inflammation. Nitric oxide (NO) has recently attracted attention in nasal polyps as it plays an important role in both acute and chronic inflammation. One of the important mechanisms controlling NO production is phosphodiesterase (PDE) enzymes. The enzyme phosphodiesterase type 5 (PDE5) is an important regulator of cyclic guanosine 3'-5'-monophosphate (cGMP) signalling. PDE5 inhibitors increase intracellular cGMP concentration by inhibiting cGMP degradation and prolong NO signalling. NO is thought to cause nasal congestion because it increases microvascular permeability and causes mucosal oedema. The aim of our study was to investigate the role of PDE5, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) in the pathophysiology of nasal polyps with mucosal oedema in histopathology.</p><p><strong>Methods: </strong>Nasal mucosal tissues were obtained from 25 patients with nasal polyps who underwent endoscopic sinus surgery as the study group and 25 patients who underwent rhinoplasty as the control group. eNOS, iNOS and PDE5 levels were measured in nasal mucosal tissues.</p><p><strong>Results: </strong>The mean age was 47.40 ± 16.33 years in the nasal polyp group and 35.44 ± 12.47 years in the normal group, and 64.0% (n = 16) of both groups were male. ELISA measurements showed that PDE5 levels were significantly decreased and iNOS and eNOS levels were significantly increased in the nasal polyp group compared with the control group. CONCLUSıON: This study suggest that iNOS, eNOS, and PDE5 may play important roles in the pathophysiology of nasal polyps.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2463-2469"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in olfactory function of adults following surgically assisted maxillary expansion.","authors":"Yun-Ting Chao, Janina Dimow, Thomas Hummel","doi":"10.1007/s00405-025-09336-6","DOIUrl":"10.1007/s00405-025-09336-6","url":null,"abstract":"<p><strong>Purpose: </strong>Surgically Assisted Rapid Maxillary Expansion (SARME) is widely used to address transverse maxillary deficiency and associated malocclusion. However, SARME-induced structural changes in the nasal cavity can influence olfactory function. This study assessed the impact of SARME on olfactory outcomes and explored the relationship between those olfactory changes and extent of maxillary expansion.</p><p><strong>Methods: </strong>This prospective study included 28 adult patients (mean age: 26.6 ± 9.4 years; range: 18-53 years) who underwent SARME for transverse maxillary deficiency. Olfactory function was evaluated preoperatively and six months postoperatively using the Sniffin' Sticks Test, which provided scores for odor threshold, discrimination, and identification. Patients were categorized into two groups based on the extent of maxillary expansion, as follows: limited (≤ 6 mm) and wide (> 6 mm). Statistical analysis was conducted to characterize changes in olfactory scores and assess their correlation with the extent of expansion.</p><p><strong>Results: </strong>SARME was shown to have a significantly positive effect on olfactory function, with the most notable enhancements observed in suprathreshold tests, such as odor discrimination and identification. Improvements in odor threshold scores, indicative of peripheral olfactory function, were more pronounced in patients that underwent limited expansion than in patients with wide expansion.</p><p><strong>Conclusion: </strong>Modifications to the nasal anatomy induced by SARME can enhance olfactory function in adults. Nonetheless, excessive maxillary expansion may hinder olfactory improvements by disrupting the nasal valve and compromising airflow dynamics. The extent of expansion should be optimized to balance improvements in nasal patency with the preservation of beneficial airflow characteristics.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2429-2436"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective study of the application of a 3D exoscope system (VITOM 3D) in ear surgery compared to conventional surgical microscopes: part I - analysis of objective parameters.","authors":"Hai Yen Tao, Joseph Morgenstern, Christoph Müller, Nikoloz Lasurashvili, Thomas Zahnert, Thomas Beleites, Marcus Neudert","doi":"10.1007/s00405-024-09096-9","DOIUrl":"10.1007/s00405-024-09096-9","url":null,"abstract":"<p><strong>Background: </strong>This prospective study compared the application of a 3D exoscope (VITOM 3D) with surgical microscopes (SM) in ear surgery.</p><p><strong>Methods: </strong>62 patients were included (exoscope group (E+) n = 31; SM group (E-) n = 31). Procedures included cochlea implantation (nE + = 10, nE- = 10), reconstructive middle ear surgery due to chronic otitis media with (COMwC; nE + = 11, nE- = 11) and without cholesteatoma (COMsC; nE + = 10, nE- = 10). Objective (e.g. set-up time and wrap-up time, corrected cut-suture-time, pure operating time, adjustment time, time per adjustment procedure, learning curves) and subjective perioperative parameters were evaluated. This paper only addressed the analysis of the objective parameters.</p><p><strong>Results: </strong>The pooled data showed that the mean time delay in the E + group was significantly higher compared to the E- group with regard to set-up time and wrap-up time, corrected cut-suture time, adjustment time and time per adjustment procedure. Time delay tended to be higher for pure operating time. In all subgroups of the E + group, the objective time parameters also showed at least a tendency to be prolonged on average compared to the corresponding subgroups in the E- group. The learning curve analysis showed that the E + group (corrected cut suture time for CI surgery, mean time per adjustment procedure across all subgroups) approached the times of the E- group during the course of the study.</p><p><strong>Conclusions: </strong>Based on the pooled data from the study arms, the exoscope tends to be inferior to the microscope for the objective time parameters evaluated when used in ear surgery. However, due to the small group sizes, no solid conclusions could be drawn regarding the individual surgical procedures. In addition, further studies with a longer observation period are needed to minimize the influence of the learning curve on the results.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2263-2274"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of anatomical variations of sphenoid sinus and the outcomes of endoscopic endonasal transsphenoidal surgeries: a systematic review.","authors":"Dur-E-Shewar Rehman, Zul Izhar Mohd Ismail, Dunia Jawdat, Syed Adnan Ali, Nur Asma Sapiai, Akeel AlAli","doi":"10.1007/s00405-024-09082-1","DOIUrl":"10.1007/s00405-024-09082-1","url":null,"abstract":"<p><strong>Background: </strong>The sphenoid sinus features many anatomical variations between individuals from different populations in the world. The understanding of these variations is important for the surgeons to plan for surgeries which involve intervention through the nasal approach. The aim of the present systematic review was to perform a qualitative synthesis of available studies which assess the effect of sphenoid sinus (SS) anatomical variations on the outcomes of endoscopic endonasal transsphenoidal surgeries (ETSS).</p><p><strong>Methods: </strong>The current review followed PRISMA 2020 guidelines. A systematic advanced electronic search was performed in four databases Medline (via PubMed), Scopus, Web of Science (WoS) and Lilacs in December 2023. Studies that assessed the anatomical variations of the SS that affect the outcomes of ETSS were eligible for inclusion. A qualitative synthesis of the methodology and results of the included studies was carried out. Quality assessment was performed using the National Institute of Health (NIH) quality assessment tool (last accessed on December 24, 2023).</p><p><strong>Results: </strong>A total of 14 studies were included in the qualitative synthesis. Most of the studies included in the review found that the sellar pneumatization was the commonest followed by the postsellar type. Single intersphenoid sinus septum (ISS) was found to be the most common variation, which is more frequently found in males compared to females. There was sex difference seen in the attachment of the ISS to the carotid canal. It is more commonly attached to the posterolateral wall of the sinus in males compared to the females. Though complicated cases were less compared to uncomplicated ones, cerebrospinal fluid (CSF) leak was the leading post operative complication amongst the complicated cases and paranasal sinus (PNS) computed tomography (CT) scan showed ISS findings differed from intraoperative findings.</p><p><strong>Conclusion: </strong>It is concluded that the ISS poses the commonest anatomical variations encountered during the ETSS. During planning for transsphenoidal endoscopic procedure, the ISS should thoroughly be assessed to minimize potential surgical complications.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2189-2202"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between abdominal visceral fat and laryngopharyngeal reflux in patients with obstructive sleep apnea.","authors":"Xiangrong Cao, Yanru Duan, Yibo Hao, Zhe Wang, Chenhai Zheng, Zhiming Zhang, Jie Qin, Dahai Wu","doi":"10.1007/s00405-025-09320-0","DOIUrl":"10.1007/s00405-025-09320-0","url":null,"abstract":"<p><strong>Purpose: </strong>To research the correlation between abdominal visceral fat and laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>This study included 72 OSA patients, and the correlation between abdominal visceral fat and the severity of LPR was analyzed after abdominal visceral fat area (VFA) was measured according to body composition analysis and reflux symptom index (RSI) score was completed. Finally, in order to further clarify the effect of VFA on LPR, multiple linear regression analysis was performed on the collected related parameters.</p><p><strong>Results: </strong>Partial correlation analysis showed that the VFA was positively correlated with the RSI score (r = 0.502, p < 0.001) after controlling for apnea-hypopnea index (AHI), body mass index (BMI), lowest oxygen saturation (LSO₂), age, and sex. The multiple linear regression analysis indicated that VFA and AHI were the factors influencing LPR (t = 4.678, p < 0.001; t = 3.164, p = 0.002).</p><p><strong>Conclusion: </strong>Our study found that VFA was associated with RSI score in OSA patients, but BMI didn't show an independent correlation with RSI score. This indicated that we should pay attention to the effect of abdominal visceral fat on LPR in OSA patients, and more experiments are needed in the future to clarify the relationship between the two.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2731-2737"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}