European Journal of Medical Research最新文献

{"title":"Intestinal barrier damage caused by addictive substance use disorder.","authors":"Yan Gao, Deshenyue Kong, Jia-Xue Sun, Zhong-Xu Ma, Guang-Qing Wang, Xing-Feng Ma, Liang Sun, Hua-You Luo, Yu Xu, Kun-Hua Wang","doi":"10.1186/s40001-025-02446-1","DOIUrl":"10.1186/s40001-025-02446-1","url":null,"abstract":"<p><p>Addictive substance use disorder has a wide range of effects on the intestinal barrier, including damage to the biological, chemical, mechanical, and immune barriers. Damage to the intestinal barrier caused by addictive substance use disorder allows harmful substances and bacteria to cross the intestinal barrier into the circulatory system, leading to systemic inflammatory responses and immune imbalances. In addition, the interaction between the gut flora and the central nervous system is recognized as an important component of the gut-brain axis. Gut barrier damage leads to dysbiosis, which in turn affects brain function by activating immune cells and releasing inflammatory factors. This may lead to altered mood and cognitive function, increased addictive substance cravings, and dependence. Recent research has indicated that reshaping the gut-brain axis and adjusting the composition and abundance of gut microbiota holds promise in alleviating withdrawal symptoms with addictive substance dependence. This article reviews the effects of addictive substance use disorder on the intestinal barrier and explores the possibility of improving addictive substance dependence by treating gut barrier damage.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"226"},"PeriodicalIF":2.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between serum albumin-globulin ratio and overactive bladder in American adults: a cross-sectional study.","authors":"Yuan-Zhuo Du, Jia-Hao Liu, Fu-Chun Zheng, Qiang Zhou, Ju Guo","doi":"10.1186/s40001-025-02441-6","DOIUrl":"10.1186/s40001-025-02441-6","url":null,"abstract":"<p><strong>Objectives: </strong>The albumin-globulin ratio (AGR) is considered an important indicator reflecting an individual's immune function and nutritional status, and it is closely associated with various health conditions. However, despite its widely studied correlations in numerous health fields, the link between AGR and Overactive Bladder (OAB) is still not completely comprehended.</p><p><strong>Methods: </strong>Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database, selecting adult samples spanning from 2007 to 2018. Through comprehensive questionnaires and laboratory tests, we gathered data pertinent to OAB and the AGR. To explore the association between AGR levels and the likelihood of developing OAB, we utilized advanced statistical techniques, such as weighted multivariate logistic regression and restricted cubic spline (RCS) models. Furthermore, we carried out subgroup analyses to assess the uniformity of this association across various demographics.</p><p><strong>Results: </strong>After adjusting for relevant covariates, we discovered a marked negative correlation between AGR levels and the risk of OAB. As AGR increased, the incidence of OAB showed a declining trend (OR = 0.69; 95% CI 0.56-0.85). Furthermore, significant nonlinear dose-response relationship was observed between AGR levels and the risk of OAB (P < 0.001), and this association remained stable in stratified analyses.</p><p><strong>Conclusions: </strong>Our results indicate that elevated AGR levels could be linked to a reduced risk of OAB. This observation highlights the potential role of AGR in assessing and preventing the occurrence of OAB.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"229"},"PeriodicalIF":2.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the same parameters measured at admission and in the ICU comparable in their predictive values for complication and mortality in severely injured patients?","authors":"Lea Gröbli, Yannik Kalbas, Franziska Kessler, Jakob Hax, Teuben Michel, Kai Sprengel, Roman Pfeifer, Martin Mächler, Hans-Christoph Pape, Sascha Halvachizadeh, Felix Karl-Ludwig Klingebiel","doi":"10.1186/s40001-025-02477-8","DOIUrl":"10.1186/s40001-025-02477-8","url":null,"abstract":"<p><strong>Introduction: </strong>Numerous studies have investigated variables that predict mortality and complications following severe trauma. These studies, however, mainly focus on admission values or a single variable. The aim of this study was to investigate the predictive quality of multiple routine clinical measurements (at admission and in the ICU).</p><p><strong>Methods: </strong>Retrospective cohort study of severely injured patients treated at one Level 1 academic trauma centre.</p><p><strong>Inclusion criteria: </strong>severe injury (ISS ≥ 16 points), primary admission and complete data set. Exclusion criteria end-of-life treatment based on advanced directive, secondary transferred patients.</p><p><strong>Primary outcome: </strong>mortality, pneumonia, sepsis. Routine clinical parameters were stratified based on measurement timepoint into Group TB (Trauma Bay, admission) and into Group intensive care unit (ICU, 72 h after admission). Prediction of complications and mortality were calculated using two prediction methods: adaptive boosting (AdaBoost, artificial intelligence, AI) and LASSO regression analysis.</p><p><strong>Results: </strong>Inclusion of 3668 cases. Overall mean age 45.5 ± 20 years, mean ISS 28.2 ± 15.1 points, incidence pneumonia 19.0%, sepsis 14.9%, death from haemorrhagic shock 4.1%, death from multiple organ failure 1.9%, overall mortality rate 26.8%. Highest predictive value for complications for Group TB include abbreviated injury scale (AIS), new injury severity score (NISS) and systemic Inflammatory Response Syndrome (SIRS) score. Highest predictive quality for complications for Group ICU include late lactate values, haematocrit, leukocytes, and CRP. Sensitivity and specificity of late prediction models using a 25% cutoff were 73.61% and 76.24%, respectively.</p><p><strong>Conclusions: </strong>The predictive quality of routine clinical measurements strongly depends on the timepoint of the measurement. Upon admission, the injury severity and affected anatomical regions are more predictive, while during the ICU stay, laboratory parameters are better predictor of adverse outcomes. Therefore, the dynamics of pathophysiologic responses should be taken into consideration, especially during decision making of secondary definitive surgical interventions.</p><p><strong>Level of evidence: </strong>III (retrospective cohort study).</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"228"},"PeriodicalIF":2.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal oxygen inhalation affects the fetal hemodynamic in low-risk with uncomplicated late pregnancy.","authors":"Xiu-Qin Wu, Xiao-Feng Yang, Lin Ye, Xiao-Bin Zhang, Yong-Qiang Hong, Wei-Hsiu Chiu","doi":"10.1186/s40001-025-02456-z","DOIUrl":"10.1186/s40001-025-02456-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Maternal oxygen inhalation during labor has not been shown to provide significant benefits to newborns. However, its impact on fetal hemodynamics in late pregnancy remains uncertain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the association between maternal oxygen inhalation in the late trimester and changes in fetal hemodynamics. Specifically, we assessed the short-term effects of maternal oxygen administration on fetal Doppler parameters and evaluated whether this practice has potential benefits or risks for the fetus.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;These retrospective data were obtained from singleton pregnancies who underwent a after 32&lt;sup&gt;+0&lt;/sup&gt; weeks prenatal ultrasound examination between January 2022 and December 2022. Participants were categorized into oxygen inhalation and non-oxygen inhalation groups. Oxygen inhalation was administered based on maternal request, primarily due to concerns about hypoxia from prolonged mask use during the COVID-19 pandemic, rather than clinical indication. Our study analysis was performed in August 2023. In oxygen inhalation group, pregnant women received oxygen inhalation with 3 L/min for 30 min by nasal cannula, and before went to department of ultrasound for sonographic assessment within 1 h. The CPR and PPI were predefined as primary outcomes prior to analysis. Each woman was recorded Doppler index and calculated placental pulsatility index (PPI) and cerebroplacental ratio (CPR). Moreover, fetal cardiac function was assessed within pulsed Doppler or M-mode.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome: &lt;/strong&gt;The primary outcome presented higher PPI, lower CPR, and lower birth weight for the exposure maternal oxygen inhalation group, compare to non-oxygen inhalation group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 104 singleton pregnancies were included in the final analysis (oxygen inhalation group: n = 48). No significant differences were observed in the resistance indices of the uterine arteries, umbilical arteries, middle cerebral arteries, descending aorta, ductus venosus, or umbilical vein. However, variations were noted in the oxygen inhalation group. Notably, indices with higher sensitivity for predicting adverse outcomes demonstrated significant differences between groups: PPI was higher in the oxygen inhalation group compared to the non-oxygen inhalation group (0.81 ± 0.12 vs. 0.76 ± 0.11, p &lt; .05), while CPR was also lower in the oxygen inhalation group (1.98 ± 0.56 vs. 2.28 ± 0.70, p &lt; .05). Additionally, birth weight was significantly lower in the oxygen inhalation group compared to the non-oxygen inhalation group (2983.78 ± 468.18 g vs. 3178.41 ± 477.59 g, p &lt; .05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study found that brief maternal oxygen inhalation in the third trimester was associated with significant changes in fetal hemodynamics, specifically higher PPI and lower CPR. Both of these indices are sensitive markers of unfavorable pren","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"222"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TEAD4-DYNLL1 axis accelerates cell cycle progression and augments malignant properties of lung adenocarcinoma cells.","authors":"Dapeng Li, An Wang, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dayu Huang","doi":"10.1186/s40001-025-02500-y","DOIUrl":"10.1186/s40001-025-02500-y","url":null,"abstract":"<p><strong>Background: </strong>Lung adenocarcinoma (LUAD) is a major contributor to global mortality. Grounded onto bioinformatics insights, this study probes the functions of dynein light chain LC8-type 1 (DYNLL1) in LUAD progression.</p><p><strong>Methods: </strong>DYNLL1 levels in LUAD and normal cells were determined using qPCR and western blotting analyses. Lentiviral plasmids-mediated DYNLL1 silencing was induced in LUAD cells, followed by functional assays to investigate DYNLL1's impacts on proliferation, mobility, apoptosis, and cell cycle distribution. KY19382, a Wnt/β-catenin agonist, was employed to analyze the involvement of the Wnt/β-catenin pathway in DYNLL1's effects. Upstream regulator of DYNLL1 was queried using bioinformatics. Mouse LUAD cells LA795 were implanted into BALB/c nude mice to establish animal tumor models.</p><p><strong>Results: </strong>DYNLL1 exhibited heightened expression in LUAD cells. Its artificial silencing reduced proliferation and dissemination of cancer cells, promoted cell apoptosis, and induced G0/G1 cell cycle arrest. DYNLL1 silencing reduced β-catenin levels in cancer cells, and KY19382 treatment diminished the effects induced by DYNLL1 silencing. TEA domain transcription factor 4 (TEAD4), upregulated in LUAD cells, binds to the DUNLL1 promoter for transcriptional activation. TEAD4 silencing in LUAD cells reduced DYNLL1 transcription and β-catenin levels, thus suppressing proliferation while promoting apoptosis, senescence, and cell cycle arrest. In vivo, TEAD4 silencing weakened tumorigenesis of LA795 cells. Nevertheless, these phenomena were counteracted by the artificial DYNLL1 restoration in LUAD cells.</p><p><strong>Conclusion: </strong>This investigation demonstrates a TEAD4-DYNLL1 axis that accelerates cell cycle progression and augments malignant properties of LUAD cells via the Wnt/β-catenin pathway.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"221"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic airway inflammatory diseases and e-cigarette use: a review of health risks and mechanisms.","authors":"Xing Yang, Wenqi Che, Lu Zhang, Huanping Zhang, Xiaoxue Chen","doi":"10.1186/s40001-025-02492-9","DOIUrl":"10.1186/s40001-025-02492-9","url":null,"abstract":"<p><p>Chronic airway inflammatory diseases, which primarily include chronic obstructive pulmonary disease (COPD), asthma, allergic rhinitis, and chronic sinusitis, continue to have a high global prevalence, highlighting their significant public health impact. Concurrently, the use of e-cigarettes (tobacco e-cigarettes) has been rising worldwide, with many users perceiving them as a safer alternative to traditional cigarettes. However, accumulating evidence from international studies suggests that e-cigarettes pose substantial health risks. This review aims to explore recent research on the relationship between e-cigarette use and chronic airway inflammatory diseases. The findings indicate that e-cigarette usage increases the risk of developing these conditions. Specifically, studies have shown that e-cigarettes exacerbate airway inflammatory responses, elevate levels of type 2 inflammatory cytokines such as IL-4, IL-5, and IL-13, increase cellular oxidative stress, and impair lung function. These mechanisms may collectively contribute to an increased risk of chronic airway inflammatory diseases potentially associated with e-cigarette use.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"223"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell transfusion strategy in traumatic brain injury patients: a systematic review and meta-analysis.","authors":"Jing Wang, Xiang-Hui Li, Jiang-Quan Yu, Rui-Qiang Zheng","doi":"10.1186/s40001-025-02498-3","DOIUrl":"10.1186/s40001-025-02498-3","url":null,"abstract":"<p><strong>Background: </strong>The optimal red blood cell transfusion (RBCT) strategy for traumatic brain injury (TBI) patients remains a topic of debate. This systematic review and meta-analysis aimed to compare the outcomes of a liberal transfusion strategy versus a restrictive strategy in critically ill patients with TBI.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase, and Cochrane Library were searched from inception to November 17, 2024. We included randomized controlled trials (RCTs) of critically ill adult patients with TBI, reporting data on RBCT strategies. The outcomes included intensive care unit (ICU) mortality, long-term mortality, unfavorable functional outcomes, and the incidence of adverse events, such as transfused acute respiratory distress syndrome (TARDS) and venous thromboembolism. We also performed subgroup analyses comparing the association between disease severity and long-term mortality. This review was submitted to PROSPERO (Registration number: CRD42024558797).</p><p><strong>Results: </strong>In the results, our analysis revealed that compared to a restrictive transfusion strategy, a liberal strategy did not significantly reduce the risk of ICU mortality (RR: 0.74; 95% CI 0.28-1.91; P = 0.53) and long-term mortality (RR: 1.02; 95% CI 0.83-1.25; P = 0.87), but it was able to reduce the risk of unfavorable functional outcomes (RR: 0.90; 95% CI 0.82-0.98; P = 0.01), although there may be a false positive error. In addition, the liberal transfusion strategy was associated with a higher incidence of Transfused Acute Respiratory Distress Syndrome (TARDS) (RR: 1.78; 95% CI 1.06-2.98; P = 0.03).</p><p><strong>Conclusions: </strong>In critically ill patients with TBI, a liberal RBCT strategy appears to improve functional outcomes but carries the risk of false positive errors. In addition, this strategy does not seem to improve survival and may increase the risk of TARDS. Despite this, there remains insufficient evidence to recommend either strategy in this population.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"220"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights.","authors":"Zihan Chen, Zongwei Huang, Yuhui Pan, Youliang Weng, Zijie Wu, Jing Wang, Wenxi Wu, Xinyi Hong, Xin Chen, Sufang Qiu","doi":"10.1186/s40001-025-02425-6","DOIUrl":"10.1186/s40001-025-02425-6","url":null,"abstract":"<p><strong>Background: </strong>Studies on the epidemiological characteristics, treatment strategies and prognosis of nasal and paranasal sinus cancer are still relatively limited.</p><p><strong>Methods: </strong>This study analyzed the age-adjusted incidence rates of nasal and paranasal sinus cancer from 1975 to 2020 using SEER database data. We conducted an in-depth examination of patients diagnosed between 2004 and 2015 with SEER*Stat software. A retrospective study from Fujian Provincial Cancer Hospital (2013-2020) provided an external validation set. Multiple imputation methods in R were used to address missing data. Survival analyses were performed using Kaplan-Meier and Cox proportional hazards models. Additionally, ten advanced machine learning models were utilized and evaluated in Python to predict patient survival outcomes.</p><p><strong>Results: </strong>This study analyzed data from 3,190 patients. The annual percent change (APC) in incidence rates per 100 000 person-years was 0.36 until 2012, subsequently decreasing to - 1.79. Among various predictive models, the gradient boosting classifier demonstrated superior performance with an area under the curve (AUC) of 0.699 and an accuracy rate of 0.708. Chemotherapy did not significantly influence overall mortality risk (HR = 0.93, 95% CI 0.82-1.05, P = 0.27). Chemotherapy showed potential benefits in specific patient subgroups.</p><p><strong>Conclusions: </strong>This study revealed a declining trend in incidence rates beginning in 2012. The gradient boosting model demonstrated robust performance, playing a crucial role in predicting patient prognosis and the significance of chemotherapy.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"218"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic mesenteric phlebosclerosis: a rare but important disease in Asian populations.","authors":"Xiao-Tong Hu, Dong Wang","doi":"10.1186/s40001-025-02505-7","DOIUrl":"10.1186/s40001-025-02505-7","url":null,"abstract":"<p><p>Idiopathic mesenteric phlebosclerosis (IMP) is a rare form of ischemic colitis that predominantly impacts Asian populations. Despite some recognizable signs, there is a significant lack of awareness about IMP. In this review, we explore the etiology, pathogenesis, imaging manifestations, endoscopic traits, and therapeutic modalities of IMP. In addition, we discuss the deficiencies in the current comprehension of IMP and the potential research orientations in future.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"219"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based risk prediction model for arteriovenous fistula stenosis.","authors":"Peng Shu, Ling Huang, Shanshan Huo, Jun Qiu, Haitao Bai, Xia Wang, Fang Xu","doi":"10.1186/s40001-025-02490-x","DOIUrl":"https://doi.org/10.1186/s40001-025-02490-x","url":null,"abstract":"<p><strong>Background: </strong>Arteriovenous fistula stenosis is a common complication in hemodialysis patients, yet effective predictive tools are lacking. This study aims to develop an interpretable machine learning model for stenosis risk prediction.</p><p><strong>Methods: </strong>Clinical data from 974 patients (55 features) undergoing arteriovenous fistula dialysis at The Central Hospital of Wuhan (2017-2024) were analyzed retrospectively. The dataset was split into training (70%) and test (30%) sets. Seven models-Random Forest, XGBoost, Support Vector Machine, Logistic Regression, K-Nearest Neighbors, Artificial Neural Network, and Decision Tree-were trained. Performance was evaluated using F1 score, accuracy, specificity, precision, recall, and AUC-ROC. SHAP values identified key predictors in the optimal model.</p><p><strong>Results: </strong>XGBoost achieved the highest AUC (0.829, 95% CI 0.785-0.880). SHAP analysis highlighted seven critical predictors: number of surgeries, prothrombin time activity, lymphocyte count, fistula duration, triglycerides, vitamin B12, and C-reactive protein.</p><p><strong>Conclusion: </strong>The XGBoost model effectively predicts arteriovenous fistula stenosis risk using clinical data. SHAP explanations enhance clinical interpretability, aiding personalized care strategies.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"217"},"PeriodicalIF":2.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}