European Journal of Medical Research最新文献

{"title":"Prognostic value of the ARISCAT score for postoperative pneumonia in patients with esophageal squamous cell carcinoma: a retrospective cohort study.","authors":"Peng Zhang, Yunyun Chen, Zhiyun Xu, Tingting Qin, Yueqin Yang, Changying Liu, Jianqiang Zhao, Hui Xia","doi":"10.1186/s40001-025-03189-9","DOIUrl":"10.1186/s40001-025-03189-9","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pneumonia remains one of the most common and serious complications after esophagectomy for esophageal squamous cell carcinoma, significantly impairing recovery and survival outcomes. Accurate preoperative risk stratification is critical, yet no widely validated scoring system currently exists for ESCC-specific surgical cohorts. The ARISCAT score, a preoperative risk index developed to estimate pulmonary complication risk in general surgery, has not been previously assessed in ESCC patients. This study aimed to evaluate the prognostic value of the ARISCAT score and its integration with other perioperative indicators for predicting postoperative pneumonia.</p><p><strong>Methods: </strong>This retrospective cohort study included 366 patients with histologically confirmed resectable ESCC who underwent curative thoraco-laparoscopic McKeown esophagectomy at a high-volume thoracic surgery center between January 2019 and December 2022. The ARISCAT score and other clinical parameters, including tumor length, length of hospital stay, PNI, and LMR, were collected preoperatively. Postoperative pneumonia was diagnosed based on radiologic, clinical, and laboratory criteria within 30 days after surgery. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of pneumonia. Restricted cubic spline modeling was used to assess non-linear associations.</p><p><strong>Results: </strong>Postoperative pneumonia occurred in 99 of 366 patients (27.0%). Patients with pneumonia had significantly higher ARISCAT scores (59.6 ± 8.9 vs. 44.4 ± 7.6), longer tumor lengths (4.5 ± 0.7 cm vs. 3.8 ± 0.6 cm), and prolonged hospital stays (17.6 ± 2.8 vs. 13.6 ± 2.3 days), along with lower PNI and LMR values (all p < 0.001). In multivariate analysis, the ARISCAT score was independently associated with postoperative pneumonia (adjusted OR = 1.40, 95% CI 1.22-1.60, p < 0.001). Other independent predictors included tumor length (adjusted OR = 12.44), length of hospital stay (adjusted OR = 2.64), PNI (adjusted OR = 0.79), and LMR (adjusted OR = 0.18). RCS analysis revealed linear dose-response relationships for ARISCAT and tumor length, while LMR and hospital stay showed non-linear associations with pneumonia risk. No significant interaction effects were observed across subgroups.</p><p><strong>Conclusions: </strong>The ARISCAT score is an independent and robust predictor of postoperative pneumonia in ESCC patients undergoing McKeown esophagectomy. This study represents the first comprehensive evaluation of the ARISCAT score in an ESCC-specific surgical cohort, and uniquely demonstrates that its integration with inflammatory (LMR) and nutritional (PNI) markers significantly enhances preoperative risk stratification. These findings offer valuable clinical insights for personalized perioperative management.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"899"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study.","authors":"Sheng Chen, Xuejin Ye, Lin Guo, Xiaohan Ma, Lingling Wu, Yiwen Li, Minsheng Wu, Rong Tang, Ting Zhang, Peng Jiang, Hongjun Gao, Minghe Jiang","doi":"10.1186/s40001-025-03186-y","DOIUrl":"10.1186/s40001-025-03186-y","url":null,"abstract":"<p><strong>Background: </strong>The prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.</p><p><strong>Methods: </strong>We performed a retrospective multicenter cohort study using MIMIC-IV and eICU-CRD. Adults with AKI and an admission MCHC (first 24 h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.</p><p><strong>Results: </strong>Among 111,817 patients (MIMIC-IV n = 54,422; eICU-CRD n = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank p < 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.65, 95% CI 0.60-0.70; eICU-CRD HR 0.62, 95% CI 0.58-0.66). Spline analyses suggested a nonlinear association in MIMIC-IV and an approximately linear association in eICU-CRD.</p><p><strong>Conclusions: </strong>Admission MCHC was associated with 30-and 90-day mortality in ICU patients with AKI across two large databases. MCHC may aid risk stratification in this population.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"914"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head circumference as an early predictor of fetal death in fetuses with increased nuchal translucency: evidence from a multicenter cohort study.","authors":"Jiang-Nan Wu, Lin-Liang Yin, Xue-Dong Deng, Chun-Ya Ji, Qi Pan, Zhong Yang, Jin-Lian Xiang","doi":"10.1186/s40001-025-03177-z","DOIUrl":"10.1186/s40001-025-03177-z","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the value of early gestational head circumference (HC) for predicting subsequent fetal death in women whose fetuses had increased nuchal translucency (NT).</p><p><strong>Methods: </strong>Gestational age-specific NT and HC Z scores were calculated. The threshold for NT was confirmed by comparing the difference in HC predictive value for fetal death (including early fetal death [12-19 weeks] and stillbirth [≥ 20 weeks]) between NT groups (normal or increased NT). Thresholds for HC prediction of fetal death in fetuses with increased NT were confirmed, with corresponding sensitivity and specificity. The performance and clinical value of the model were evaluated. Multiple imputation method was conducted to assess the robustness of the results.</p><p><strong>Results: </strong>A total of 16,436 women and their fetuses were included in the analysis. Fetal HC was lower in fetal deaths than in live births (P < 0.005). The 80th percentile was a preferred threshold for increased NT. The difference in HC between live and dead fetuses persisted in fetuses with NT > 80th percentile (median of HC Z score: - 0.66 vs. 0.34, P < 0.001), but not in those with NT ≤ 80th percentile. The HC Z score was valuable for predicting fetal death in fetuses with increased NT, with a sensitivity of 74% and specificity of 76%. The prediction was useful for early fetal death, not stillbirth. Internal validation showed that the model has good predictive performance and clinical utility. Multiply imputation analysis shows that the association of low HC with fetal death and its predictive value were weakened.</p><p><strong>Conclusions: </strong>The early gestational age-specific HC Z score was associated with fetal death, particularly early fetal death, in fetuses with NT above the 80th percentile. Definitive validation through large-scale cohorts with protocol-based routine HC measurements is warranted before considering clinical application.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"898"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality control of ultrasound at 11 to 14 weeks of gestation: results from the China Early Pregnancy Ultrasound Cohort.","authors":"Jingjing Wang, Wenjia Lei, Yantong Zhu, Na Zhang, Shijing Song, Li Wang, Qingqing Wu","doi":"10.1186/s40001-025-03156-4","DOIUrl":"10.1186/s40001-025-03156-4","url":null,"abstract":"<p><strong>Objective: </strong>To assess the quality control (QC) of ultrasound scanning at 11-14 weeks of gestation during the first stage in the China Early Pregnancy Ultrasound Cohort (CEPUC).</p><p><strong>Methods: </strong>A stratified random sampling strategy was employed for QC on ultrasound images from 525 single fetuses between 11 and 13 ⁺⁶ weeks of gestation across nine hospitals. The QC process consisted of two elements: (1) the retention of 17 types of ultrasound scans and (2) the assessment of each scan's content, which was scored out of 47 points. QC was performed twice: initially through hospital self-assessment (self-QC) and a subsequent review by the cohort team (second QC). The QC scores were calculated and compared across different groups using the Chi-square test, Fisher's exact test, or the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>The median number of retained ultrasound scans per person was 16.0 (interquartile range: 15.0-17.0). The median scores for self-QC and second QC were 44 points (interquartile range: 40-47) and 43 points (interquartile range: 38-46), respectively. The second QC scores were significantly lower than the self-QC scores (P < 0.001), with 225 cases (42.9%) scoring lower and 280 cases (53.3%) scoring equally. Excluding image magnification, the three items with the lowest scoring rates among the other 37 were: (1) coronal view of the cervical spine to the sacrum (62.3%), (2) assessing regurgitation in the tricuspid valve spectrum of the heart (63.4%), and (3) obtaining a three-dimensional (3D) image of the choroid plexus Sect. (78.1%).</p><p><strong>Conclusions: </strong>QC in ultrasound is crucial for multicenter cohort studies, ensuring consistency and reliability across various sites. Both subjective and objective measurements should be seriously considered.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"891"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined blood purification and antiarrhythmic therapy for acute aconitine poisoning with refractory arrhythmias: a case-based mechanistic evaluation and treatment strategy optimization.","authors":"Cheng Yang, Ting Zou, Qian-Hui Zang, Wei Cao, Yuan Suo","doi":"10.1186/s40001-025-03167-1","DOIUrl":"10.1186/s40001-025-03167-1","url":null,"abstract":"<p><strong>Introduction: </strong>Aconitine poisoning from traditional Chinese medicine is life-threatening, associated with arrhythmias and shock. Early diagnosis and multidisciplinary treatment are essential due to the lack of specific antidotes. This study aimed to present a severe case of aconitine poisoning and to evaluate the effectiveness of combined blood purification and antiarrhythmic therapy, thereby providing practical insights for clinical management. A 70-year-old man presented with coma, recurrent ventricular arrhythmias, and severe hypotension (nadir: 44/24 mmHg) after ingesting Fuzhi (Aconitum taipeicum). Toxicology confirmed high aconitine levels. He was treated with norepinephrine (0.17-0.33 μg/kg/min), intravenous amiodarone (150 mg bolus over 10-15 min, then 1 mg/min infusion), electrical cardioversion, and early blood purification (hemoperfusion + CVVH). He regained hemodynamic stability within 24 h and fully recovered at 6 months (LVEF 59-63%).</p><p><strong>Conclusions: </strong>Combined antiarrhythmic therapy and blood purification proved effective. Early recognition and integrated care are key to managing aconitine poisoning.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"913"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise on neuroinflammation in age-related neurodegenerative disorders.","authors":"Yiping Su, Zhanguo Su","doi":"10.1186/s40001-025-03165-3","DOIUrl":"10.1186/s40001-025-03165-3","url":null,"abstract":"<p><p>Neuroinflammation plays a critical role in the pathogenesis of aging-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis. It involves the activation of glial cells and the release of pro-inflammatory mediators and reactive oxygen and nitrogen species, which, when chronically sustained, contribute to neuronal damage and cognitive decline. Recent evidence suggests that regular physical exercise exerts neuroprotective effects by modulating neuroinflammatory pathways and enhancing brain health. Exercise has been shown to regulate the activity of microglia and astrocytes, strengthen the blood-brain barrier, and reduce systemic and gut-derived inflammation-all of which are implicated in the progression of neurodegeneration. Additionally, exercise influences inflammasome signaling, a key component in the innate immune response, further mitigating inflammation-induced neuronal injury. This review summarizes current findings on the impact of physical activity on inflammation and inflammasome pathways in aging-related neurodegenerative diseases, highlighting the therapeutic potential of exercise as a non-pharmacological intervention. Further research is warranted to optimize exercise protocols for maximal neuroprotective benefits.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"909"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural alterations correlate with motor dysfunction in children with spastic cerebral palsy: a quantitative MRI study.","authors":"Qiang Wang, Jiale Zhang, Xiang Ren, Qijia Zhan, Wenbin Jiang","doi":"10.1186/s40001-025-03194-y","DOIUrl":"10.1186/s40001-025-03194-y","url":null,"abstract":"<p><strong>Background: </strong>Spastic cerebral palsy (CP) is a common cause of motor disability in children which caused by non-progressive brain injury. This study aimed to investigate the correlation between quantitative brain MRI parameters and motor dysfunction in children with spastic CP.</p><p><strong>Methods: </strong>91 children with spastic CP and 91 controls were recruited. Brain volumes were measured using high-resolution T1-weighted Magnetic resonance imaging (MRI). Gross motor function was assessed using Gross Motor Function Measure-66 score (GMFM-66) and the muscle tone was evaluated by modified Ashworth scale and scored by modified Ashworth scale score.</p><p><strong>Results: </strong>Children with spastic CP showed significantly reduced total brain volume, white matter volume, gray matter volume, and white matter/total brain volume ratio compared to controls. In children with spastic CP, white matter volume and white matter/total brain volume ratio positively correlated with GMFM-66 scores (r = 0.56, p < 0.001; r = 0.47, p < 0.001). The muscle tone of specific muscles negatively correlated with brain volumes.</p><p><strong>Conclusions: </strong>White matter volumes are closely related to motor dysfunction in children with spastic CP. Quantitative MRI may serve as objective biomarkers for evaluating the severity and prognosis of spastic CP, providing basis for individualized rehabilitation strategies.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"906"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-enabled identification of nucleus pulposus senescence-associated genes as potential biomarkers for intervertebral disc degeneration.","authors":"Min Xiang, Qingping Peng, Feifei Dai, Yanjiao Wu, Ling Liu, Huan Liu","doi":"10.1186/s40001-025-03102-4","DOIUrl":"10.1186/s40001-025-03102-4","url":null,"abstract":"<p><strong>Background: </strong>Intervertebral disc degeneration (IVDD) has risen to become a global health problem, and its mechanisms are not well understood. The aim of this study was to use machine learning methods to identify key medullary senescence genes associated with IVDD and to further screen for potential biomarkers, as well as to explore the pathways by which these genes can be analyzed in both IVDD and normal states.</p><p><strong>Methods: </strong>Gene expression profiles (GSE70362) of IVDD were analyzed from the extensive Gene Expression Omnibus database, and senescence-related genes (SRGs) were obtained from the cell age database. We utilized the Kyoto Encyclopedia of Genes (KEGG) and Gene Ontology (GO) databases for comprehensive functional enrichment analysis. To identify Hub SRDEGs with highly correlated IVDD features (Hub IVDD-SRDEGs), Weighted Gene Co-expression Network Analysis (WGCNA) and two machine learning methods (random forest, and support vector machine recursive feature elimination) were used. Finally, external validation was performed using quantitative polymerase chain reaction (qPCR) and Western blot experiment, and clinic samples validation was also performed using quantitative polymerase chain reaction (qPCR) experiment.</p><p><strong>Results: </strong>We discovered 470 DEGs in normal and IVDD nucleus pulposus samples. According to functional enrichment, DEGs are primarily associated with positive regulation of transcription from RNA polymerase II promoter, canonical Wnt signaling pathway, mitotic spindle assembly, response to organic cyclic compound, and cardiac muscle cell apoptotic process. In vivo experiments (qPCR and WB) verified the expression of TAF13 protein. Subsequent qPCR of human nucleus pulposus tissue also showed the same trend of TAF13 gene expression. Hub IVDD-SRDEGs with excellent IVDD diagnostic ability were identified as TAF13.</p><p><strong>Conclusions: </strong>Nucleus pulposus aging may promote the progression of IVDD. TAF13 can be used as a novel diagnostic biomolecular marker and for IVDD.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"887"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gout, hyperuricemia, and Parkinson's disease: a systematic review and meta-analysis.","authors":"Fares A Qtaishat, Muaath I Alsufi, Jehad A Yasin, Abdallah Abunamoos, Izere Salomon, Sara Qutaishat, Ramez M Odat","doi":"10.1186/s40001-025-03202-1","DOIUrl":"10.1186/s40001-025-03202-1","url":null,"abstract":"<p><strong>Background: </strong>The association between gout, hyperuricemia, and Parkinson's disease (PD) has been widely debated with conflicting findings across studies. Although the antioxidant properties of urate suggest a potential neuroprotective role, chronic inflammation in gout may negate this benefit.</p><p><strong>Objectives: </strong>To systematically evaluate the relationship between gout, hyperuricemia, and the risk of developing PD through a comprehensive review and meta-analysis of observational studies.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we systematically searched PubMed, Web of Science, Scopus, and Embase (inception-May 2024) for observational studies. Data were extracted from 19 eligible studies (N = 15,571,392 participants). Random-effects meta-analysis was used to estimate the pooled risk ratios (RRs) for PD among individuals with gout or hyperuricemia. Subgroup analyses were conducted based on sex, age, and effect size. Heterogeneity was assessed using I² statistics, and publication bias was evaluated using funnel plots and Egger's test.</p><p><strong>Results: </strong>Nineteen studies were included in this meta-analysis. Eight of the eight studies reported a protective effect of hyperuricemia, whereas four of the 12 studies reported a protective effect of gout. A meta-analysis showed no significant association between gout and PD (RR 0.99, 95% CI 0.90-1.08); however, hyperuricemia was associated with a reduced risk of PD (RR 0.69, 95% CI 0.56-0.85). In the gender-stratified analysis, gout showed no significant association with PD in males (RR 0.94, 95% CI 0.84, 1.05) or females (RR 1.07, 95% CI 0.96, 1.19), whereas hyperuricemia was more protective in males (RR 0.48, 95% CI 0.24, 0.97) than in females (RR 0.84, 95% CI 0.44, 1.61). Age-based analysis indicated that both hyperuricemia and gout were associated with a lower PD risk in individuals aged < 75 years; however, no significant protective effect was observed in individuals aged ≥ 75 years.</p><p><strong>Conclusion: </strong>This meta-analysis found no significant association between gout and PD but supports a potential neuroprotective role of hyperuricemia, particularly in males and younger individuals. However, considering the limitations of evidence in the literature, the results need to be interpreted cautiously, and further studies may be required to explore clinical relevance after adjusting for possible modifying factors.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"904"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative EEG analysis related to coma and prognosis in acute severe cerebral infarction.","authors":"Shirui Wen, Peihong Li, Sha Huang, Li Feng, Xiaobo Zhang","doi":"10.1186/s40001-025-03191-1","DOIUrl":"10.1186/s40001-025-03191-1","url":null,"abstract":"<p><strong>Introduction: </strong>While electroencephalographic (EEG) abnormalities in acute cerebral infarction are increasingly documented, their neuroanatomical specificity and underlying pathophysiology remain poorly understood. This study investigated how lesion topography (cortical vs. brainstem) shapes distinct cortical oscillatory patterns and their clinical correlates in severe infarction with impaired consciousness.</p><p><strong>Methods: </strong>We analyzed EEG recordings from 15 large hemispheric infarction (LHI) patients, 13 brainstem infarction (BSI), and 14 healthy control subjects. Quantitative EEG (qEEG) metrics included absolute/relative band power (ABP/RBP) and functional connectivity (FC) across delta (δ), theta (θ), alpha (α), and beta (β) bands. Correlations between quantitative EEG (qEEG) parameters and clinical outcomes were also assessed.</p><p><strong>Results: </strong>The BSI group exhibited significantly elevated δ-band ABP/RBP alongside attenuated α/β-band power compared to LHI group (all p < 0.001). Notably, in the non-ipsilesional occipital region, enhanced δ/β-band activity demonstrated positive correlations with favorable clinical outcomes, whereas increased θ/α bands activities showed inverse prognostic associations. Furthermore, LHI patients exhibited stronger δ-band functional connectivity between the non-ipsilesional frontal-occipital networks (p < 0.01).</p><p><strong>Conclusions: </strong>This study delineates distinctive EEG signatures characterizing severe cerebral infarction, establishing non-ipsilesional occipital qEEG parameters as pivotal biomarkers for both consciousness evaluation and outcome prediction. These objective electrophysiological markers not only differentiate LHI from BSI through network-level neural reorganization patterns, but also demonstrate clinical applicability. The findings provide empirical support for qEEG integration into neurocritical care for acute stroke with impaired consciousness.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"916"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}