European Journal of Medical Research最新文献

{"title":"Tai Chi improves balance, mobility and gait function of the lower limbs in patients with Parkinson's disease: a systematic review and meta-analysis.","authors":"Lijie Lou, Chunyu Xiang, Yingliang Hu, Jiapeng Yang","doi":"10.1186/s40001-024-02151-5","DOIUrl":"10.1186/s40001-024-02151-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to systematically evaluate the effect of Tai Chi on the balance function, mobility function, and gait function (including gait endurance, gait amplitude, and gait speed) of the lower limbs in patients with Parkinson's disease.</p><p><strong>Methods: </strong>The \"PICOS\" principle was used to search seven English and six Chinese databases. Search for relevant studies published up to September 11, 2023, from the date of database creation. Two authors independently screened all eligible studies. The included studies were assessed for risk of bias based on the criteria outlined in Cochrane Handbook 5.1.0. Quantitative statistics and meta-analyses were conducted using Review Manager 5.4 software.</p><p><strong>Results: </strong>Th 18 studies that met the inclusion criteria, 16 of which were included in the meta-analysis, included a sample of 963 cases from four countries. The meta-analysis revealed that Tai Chi was effective compared with conventional medication in improving balance function (MD = 2.06, 95% CI [1.35, 2.78], P < 0.00001, I² =0%), mobility function (MD = - 1.59, 95% CI [- 2.28, - 0.91], P < 0.00001, I² =14%), and gait speed (SMD =0.59, 95% [0.28, 0.91], P = 0.0002, I² =29%). However, there was no significant improvement in gait endurance (SMD = 0.14, 95% CI [-0.41, 0.68], P =0.62, I² = 0%) or gait amplitude (SMD =0.30 , 95% CI [- 0.00, 0.61], P = 0.05, I² =0%). Compared with other exercise therapies, Tai Chi was significantly superior in improving balance function (MD = 3.05, 95% CI [1.94, 4.16], P <0.00001, I² = 38%), mobility function (MD =-0.70, 95%CI [- 1.23, - 0.17], P = 0.01, I² = 0%), and gait range (SMD = 0.36, 95% CI [0.14, 0.58], P = 0.002, I² = 45%). However, the advantage of improving gait speed (SMD =0.00, 95% CI [- 0.28, 0.29], P = 0.98, I² =0%) was uncertain.</p><p><strong>Conclusion: </strong>Tai chi is a safe and effective rehabilitation intervention that can enhance the balance and mobility functions of the lower limbs in patients with Parkinson's disease.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"107"},"PeriodicalIF":2.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of long-term nasogastric tube feeding and tracheostomy on pharyngeal and laryngeal structure in ABI patients: an FEES study.","authors":"Tingwei Wang, Jiahui Tai, Ruiping Hu, Qun Zhang, Yiwen Shen, Yulian Zhu, Yi Wu, Junfa Wu","doi":"10.1186/s40001-025-02375-z","DOIUrl":"10.1186/s40001-025-02375-z","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the characteristics of pharyngeal and laryngeal structure in patients with acquired brain injury (ABI), who were long time wearing nasogastric tube (NGT) with or without tracheostomy.</p><p><strong>Methods: </strong>103 ABI patients with NGT indwelled for more than 1 month were retrospectively studied and divided into two groups by whether or not undergoing tracheostomy. Age, gender, types of brain injury, course of the disease, disorders of consciousness, activities of daily living (ADL) and fiberoptic endoscopic examination of swallowing (FEES) were evaluated. The structure and function of pharyngeal and laryngeal were assessed by FEES, focusing on the morphology of the arytenoid cartilage, epiglottis, vocal folds, tongue base, and pharyngeal cavity.</p><p><strong>Results: </strong>Prolonged indwelling nasogastric tubes and tracheostomy tubes might lead to abnormal alterations of the structure and function in the arytenoid cartilage, epiglottis, tongue base, and pharyngeal cavity. Epiglottis shape abnormality, glossoptosis and pharyngeal stenosis were present in a larger proportion of the NGT-TRACH (nasogastric tube with tracheostomy) group than the NGT group (p < 0.05).</p><p><strong>Conclusions: </strong>This study highlights potential physiological changes associated with prolonged placement of nasogastric tubes and tracheostomy tubes, which could impede the recovery of swallowing function and decannulation. We hope to provide valuable evidence to develop effective management strategies for ABI patients with NGT or tracheostomy.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"109"},"PeriodicalIF":2.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total fat intake and fatty acid patterns and prediabetes regression: differential effects across phenotypes in a population-based cohort.","authors":"Zahra Bahadoran, Zahra Kashani, Maryam Mahdavi, Parvin Mirmiran, Fereidoun Azizi","doi":"10.1186/s40001-025-02337-5","DOIUrl":"10.1186/s40001-025-02337-5","url":null,"abstract":"<p><strong>Background and aim: </strong>This cohort study investigated the potential association between dietary fat intakes and returning to normal glucose regulation (NGR) in different prediabetes (Pre-DM) phenotypes.</p><p><strong>Methods: </strong>A total of 1587 Pre-DM subjects consisting of 60.2% isolated impaired fasting glucose (iIFG), 21% isolated impaired glucose tolerance (iIGT), and 18.8% combined IFG-IGT, were recruited for baseline dietary assessment and were followed for changes in glycemic status (i.e., returned to NGR, remained Pre-DM, or progressed to diabetes) over 9 years. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for returning to NGR across categories of fat intake (< 20%, 20-30%, and > 30% of total energy intake), and tertiles of major fat patterns identified through principal component analysis (PCA).</p><p><strong>Results: </strong>The mean age of the participants was 47.2 ± 12.9 years, and 52.2% were men. Over a median of 5.8 years of follow-up, 46.8% of Pre-DM subjects regressed to NGR. Low-fat diet (LFD) was associated with an increased chance of returning to NGR in the iIGT phenotype (HR = 1.44, 95% CI 1.05-1.98). Two major dietary fat patterns, i.e., Mixed Fat Pattern (MFP, whit a higher load of saturated fat, cholesterol, oleic, linoleic, and trans fatty acids) and ω₃FP (i.e., loaded heavily on docosahexaenoic, eicosapentaenoic, and α-linolenic acids), extracted by PCA, were corresponded to 58.4% of the total variance of fat intake. In both iIFG and iIGT phenotypes, highest MFP score was inversely associated with NGR (HR = 0.71, 95% CI 0.50-0.99 and HR = 0.60, 95% CI 0.37-0.97), while the highest ω3FP score was associated with an elevated incidence of NGR in subjects with combined IFG-IGT phenotype by twofold (HR = 2.29, 95% CI 1.00-5.29).</p><p><strong>Conclusions: </strong>Subjects with iIGT phenotype may take more advantage from adhering a LFD. Dietary fat patterns may differentially affect chance of returning to NGR across Pre-DM phenotypes.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"110"},"PeriodicalIF":2.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, single-blinded, non-inferiority, randomized controlled study comparing the effectiveness and safety of oral lactulose combined with carbohydrate-containing clear liquids versus 3-L polyethylene glycol electrolyte for colonoscopy bowel preparation.","authors":"Chen Huang, Hongli Liu, Jing Luo, Zhe Xu, Jibin Li, Xu Tian","doi":"10.1186/s40001-025-02365-1","DOIUrl":"10.1186/s40001-025-02365-1","url":null,"abstract":"<p><strong>Background: </strong>Polyethylene glycol electrolyte solution (PEG-ELS) is the standard for bowel preparation but often suffers from poor patient compliance and tolerability due to its high-volume requirement. This prospective, single-blinded, non-inferiority, randomized control trial aims to investigate the efficacy and safety of a lactulose-based regimen as an alternative for bowel preparation.</p><p><strong>Methods: </strong>Two hundred nine patients were randomly allocated to receive either a combination regimen consisting of 133.4 g lactulose in 200 mL, 800 mL carbohydrate-containing clear liquid, 2L additional water, and 5 g simethicone (n = 104) or 3L PEG-ELS with 5 g simethicone (n = 105), both administered in a split-dose format. The primary outcome was the rate of adequate bowel preparation, measured by the Boston bowel preparation score (BBPS). Adequate bowel preparation was defined as a BBPS score of 2 or 3 in all colon segments. Secondary outcomes included the percentage of high-quality bowel preparation (defining as a total BBPS score of 8 or 9), polyp detection rate (defining as the percentage of procedures where at least one polyp was detected), willingness to repeat the bowel preparation, adverse events, and changes in blood glucose and electrolyte levels.</p><p><strong>Results: </strong>The rate of adequate bowel preparation (96.2% vs. 97.1%, p = 0.691), the percentage of high-quality preparation (62.5% vs. 66.7%, p = 0.529), average total BBPS scores (p = 0.607), polyp detection rates (66.3% vs. 77.1%, p = 0.083), and tolerability and acceptability outcomes, including satisfaction (p = 0.729) and willingness to repeat preparation (p = 0.744), were not statistically different between the two arms. Adverse events and changes in blood glucose and electrolytes showed no significant differences (all p > 0.05).</p><p><strong>Conclusion: </strong>The combination of oral lactulose and carbohydrate-containing clear fluids was non-inferior to 3L PEG-ELS for bowel preparation adequacy and polyp detection, without statistically significant differences in terms of tolerability and safety.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"105"},"PeriodicalIF":2.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of a higher thiamylal induction dose in pediatric sedation for magnetic resonance imaging scans.","authors":"Yi-Shiuan Li, Shih-Pin Lin, Wen-Kuei Chang, Ting Chien-Kun","doi":"10.1186/s40001-025-02332-w","DOIUrl":"10.1186/s40001-025-02332-w","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that 3.6 (2.8-4.0) mg/kg of intravenous thiamylal is effective and safe for pediatric sedation during magnetic resonance imaging (MRI) scans, although its success rate (96.6%) is slightly lower than that via propofol (99%). This retrospective study aimed to evaluate whether a higher induction dose of thiamylal can reduce MRI scan interruptions without increasing the incidence of adverse events.</p><p><strong>Methods: </strong>This study included patients aged < 18 years who underwent MRI under thiamylal sedation between January 2021 and December 2022. Intravenous atropine (0.01 mg/kg) and midazolam (0.08 mg/kg) were administered as premedications. An induction intravenous dose of 2-5 mg/kg thiamylal was administered, with additional doses administered as needed. The induction dose was defined as the total amount of thiamylal administered before the scan. Once adequate sedation was achieved, MRI was performed. Any additional doses of thiamylal required because of scan interruption were recorded as rescue doses. Patients who received an induction thiamylal dose of < 3.6 mg/kg were categorized into the lower induction dose group. The primary endpoint was the rate of MRI interruptions. Secondary endpoints included adverse events related to sedation, total thiamylal dose, and total MRI scanning time.</p><p><strong>Results: </strong>A total of 566 patients, with a median age of 56.4 months (range: 24.0-79.2 months) and median weight of 16.0 kg (range: 10.3-21.0 kg), were included in the analysis. The median induction and total dose of thiamylal per body weight were 4.7 (3.8-5.8) mg/kg and 6.0 (4.6-8.1) mg/kg, respectively. No respiratory or other adverse events were recorded. For 30- to 60-min MRI scans, the higher induction dose group had a lower scan interruption rate, and a lower total thiamylal dose was required than that for the lower induction dose group.</p><p><strong>Conclusion: </strong>A higher induction dose of thiamylal (5.4 ± 1.6 mg/kg) is safe and is associated with a reduced scan interruption rate for 30- to 60-min MRI scans, as well as a lower total thiamylal dose requirement. However, thiamylal is not an ideal sedative agent for MRI scans longer than 1 h.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"106"},"PeriodicalIF":2.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hepatic steatosis index and glucose status conversion from impaired fasting glucose base on Chinese adults: a cohort study from real-world.","authors":"Juan Wu, Qi Chen, Jun-Zhong Zou, Yi-Ying Chen, Hua-Hong Chen, Yu-Ye Lin, Xu-Dong Huang","doi":"10.1186/s40001-025-02354-4","DOIUrl":"10.1186/s40001-025-02354-4","url":null,"abstract":"<p><strong>Objective: </strong>Evidence regarding the relationship between the hepatic steatosis index (HSI) and glycemic conversion outcomes in individuals with impaired fasting glucose (IFG) is still limited. Our study aims to explore the role of HSI in the reversion to normoglycemia or the progression to diabetes among Chinese IFG individuals.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from 11,327 IFG individuals who had undergone wellness examinations at Rich Healthcare Group. To analyze the association between the baseline HSI and glucose status conversion, a Cox regression model was used, and the hazard ratio (HR) and 95% confidence interval (CI) were computed. A generalized additive model was used to examine non-linear relationships. A two-piecewise binary logistic regression model was employed to further elucidate the non-linearity. Sensitivity and subgroup analyses were also conducted.</p><p><strong>Results: </strong>Over an observation period spanning 33,892 person-years, the rate of normoglycemia reversion was found to be 41.75%, whereas the rate of progression to diabetes was 11.63%. After accounting for potential confounding variables, our analysis demonstrated that among IFG individuals, there was an inverse relationship between HSI and the likelihood of returning to normoglycemia (HR = 0.93, 95% CI: 0.90-0.96, P < 0.001), and a positive association between the HSI and progression to diabetes (HR = 1.49, 95% CI: 1.40-1.58, P < 0.001). The smooth curve-fitting plot revealed a nonlinear association between the HSI and diabetes progression, with inflection points at 26.55 and 40.74. Sensitivity analysis and subgroup analysis confirmed the stability of the study's findings.</p><p><strong>Conclusion: </strong>HSI was significantly linked to normoglycemia reversion and diabetes progression in IFG individuals, indicating its potential as a risk indicator for diabetes and a guide for prevention strategies. However, further research is needed to confirm this.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"100"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated bulk and single-cell RNA sequencing to identify potential biomarkers in intervertebral disc degeneration.","authors":"Chunyang Fan, Wei Xu, Xuefeng Li, Jiale Wang, Wei He, Meng Shen, Di Hua, Yao Zhang, Ye Gu, Xiexing Wu, Haiqing Mao","doi":"10.1186/s40001-025-02346-4","DOIUrl":"10.1186/s40001-025-02346-4","url":null,"abstract":"<p><strong>Background: </strong>Nucleus pulposus (NP) deterioration plays a significant role in the development of intervertebral disc degeneration (IVDD) and low back pain (LBP). This paper aims to identify potential genes within degenerated NP tissue and elucidate the pathogenesis of IVDD through bioinformatics analysis.</p><p><strong>Methods: </strong>We conducted a transcriptomic analysis of patient's degenerative NP tissue employing advanced bioinformatics techniques and machine learning algorithms. Utilizing hdWGCNA, we successfully acquired WGCNA single-cell sequencing data and pinpointed crucial genes implicated in IVDD. Subsequently, we employed the Monocle3 package to perform pseudotime sequence analysis, enabling the identification of genes associated with the differentiation and developmental processes of NP tissue. Following this, normalized and logarithmically transformed the bulk sequencing data. Subsequently, we conducted preliminary screening using single-factor logistic regression on the genes derived from single-cell sequencing. Next, we applied two machine learning techniques, namely, SVM-RFE and random forest, to discern pivotal pathogenic genes. Finally, we used validation sets to verify trends and qualitativeness and performed in vitro and in vivo validation analyses of normal and degenerative NP tissues.</p><p><strong>Results: </strong>909 genes associated with IVDD were identified through hdWGCNA, while pseudotime sequence analysis uncovered 1964 genes related to differentiation and developmental processes. The two had 208 genes in common. Subsequently, we conducted an initial screening of single-cell genes by integrating the bulk database with single logistic regression. Next, we utilized machine learning techniques to identify the IVDD genes CDH, DPH5, and SELENOF. PCR analysis confirmed that the expression of CDH and DPH5 in degraded nucleus pulposus cells (NPCs) was decreased by 31% and 28% in vivo, and 36% and 29% in vitro, respectively, while SELENOF showed the opposite trend. Furthermore, IVDD was validated through imaging and histological staining.</p><p><strong>Conclusion: </strong>As pathogenic genes in IVDD, our findings indicate that CTH, DPH5, and SELENOF are important players and might be promising therapeutic targets for IVDD treatment.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"102"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosuvastatin mitigates blood-brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels.","authors":"Qin Shen, Qian Yu, Taojiang Chen, Lijuan Zhang","doi":"10.1186/s40001-025-02314-y","DOIUrl":"10.1186/s40001-025-02314-y","url":null,"abstract":"<p><strong>Background: </strong>Blood-brain barrier (BBB) disruption is a key pathological feature of sepsis-associated encephalopathy (SAE). Rosuvastatin, a third-generation statin, exhibits diverse pharmacological functions beyond its lipid-lowering capacity. However, its potential neuroprotective role in SAE remains unclear.</p><p><strong>Materials and methods: </strong>SAE models were established using the cecal ligation and puncture (CLP) method. BBB integrity was evaluated using NaF, and endothelial permeability was assessed by fluorescein isothiocyanate (FITC)-dextran assays.</p><p><strong>Results: </strong>Rosuvastatin significantly attenuated neuroinflammation in the brains of septic mice by reducing the expression of the pro-inflammatory cytokines interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor α (TNF-α). It also ameliorated vascular injury in the brain cortex of septic mice by decreasing the levels of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin. Furthermore, Rosuvastatin preserved BBB integrity in septic mice by enhancing the expression of the tight junction protein occludin. In vitro studies demonstrated that Rosuvastatin alleviated endothelial permeability and increased transendothelial electrical resistance (TEER) in lipopolysaccharide (LPS)-stimulated human brain microvascular endothelial cells (HBMECs). Additionally, Rosuvastatin prevented the LPS-induced reduction of occludin and Krüppel-like factor 2 (KLF2) in HBMECs. Importantly, silencing KLF2 abrogated Rosuvastatin's protective effects on endothelial permeability and occludin expression.</p><p><strong>Conclusions: </strong>These findings indicate that Rosuvastatin may be a promising therapeutic candidate for mitigating BBB dysfunction associated with SAE.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"103"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To evaluate the clinical efficacy of decompression for large cystic lesions in mandible by digital technology.","authors":"Xianyu Zheng, Shimin Wang, Xiaoxiao Su, Yuqing Shen, Hengguo Zhang, Lijuan Zhou, Enshun Wang, Xianyu Zheng","doi":"10.1186/s40001-025-02366-0","DOIUrl":"10.1186/s40001-025-02366-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to quantitatively evaluate the therapeutic effect of decompression on mandibular cystic lesions using three-dimensional volumetric analysis and investigate factors influencing volume reduction patterns.</p><p><strong>Methods: </strong>A retrospective cohort of 44 patients with mandibular cystic lesions, including 12 unicystic ameloblastomas (UAB), 12 odontogenic keratocysts (OKC), and 20 nonkeratinizing cysts (NKC), was analyzed. Volumetric measurements before and after decompression were obtained using Three- dimensional (3D) Slicer software and CBCT data. Outcome variables included absolute volume reduction (AVR), absolute speed of shrinkage (ASS), relative reduction in volume (RRV), and relative speed of shrinkage (RSS). Predictor variables were patient age, gender, presence of impacted teeth, mandibular ramus involvement, preoperative volume, and decompression duration. Statistical analyses were performed, with significance set at P ≤ 0.05.</p><p><strong>Results: </strong>Significant volume reductions were observed across all groups post-decompression (P < 0.01). Preoperative volume correlated positively with AVR and ASS (P < 0.05). Decompression duration was inversely related to RSS (P < 0.05) and positively related to RRV in OKC and NKC groups (P < 0.05). Other variables showed no significant associations (P > 0.05).</p><p><strong>Conclusions: </strong>Decompression effectively reduces mandibular cystic lesion volume, with preoperative size and duration of decompression being key influencing factors. Three-dimensional volumetric analysis provides detailed, reliable evaluation of treatment efficacy, enhancing clinical monitoring and decision-making.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"104"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of 45 cases of chronic respiratory failure treated by noninvasive ventilator combined with bronchodilator and anti-infective drugs.","authors":"Huwei Huang, Yuanyuan Xu, Qiaolian Li","doi":"10.1186/s40001-025-02341-9","DOIUrl":"10.1186/s40001-025-02341-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aim of this study is to investigate the therapeutic effects of a non-invasive ventilator combined with bronchodilator and anti-infective drugs in the treatment of 45 cases of chronic respiratory failure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;45 chronic respiratory failure patients who were hospitalized to our hospital between August 2019 and January 2022 were chosen as research subjects. They were randomly allocated into two groups using the random number table approach, the control group (n = 21) and the observation group (n = 24), and they were given numbers according to the sequence of treatment. Treatment as usual was given to the control group. The observation group was further treated with a bronchodilator (tiotropium bromide) and an anti-infective drug (piperacillin). The curative effect of each group after treatment was observed and compared.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After running a statistical analysis on demographic information from both groups, including gender, age, BMI, and disease severity, the results showed no significant difference between the groups (P &gt; 0.05). There was a statistically significant (P &lt; 0.05) difference between the observation group and the control group in terms of the time it took for temperatures to recover and pulmonary rales to disappear, as well as the time it took for asthma attacks to occur. Prior to therapy, there were no statistically significant differences between the two groups on blood gas indices or inflammatory indices (P &gt; 0.05). After therapy, patients in the experimental group had lower levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) compared to the controls. The oxygenation index and bacterial partial pressure of oxygen (PaO2) were both considerably higher in the experimental group compared to the control group (P &lt; 0.05). There was no significant difference between the two groups' baseline values for any of the lung function indices (P &gt; 0.05). Following treatment, patients in the treated group had significantly higher forced vital capacity (first second forced vital capacity, first second forced vital capacity, contents of FEV1), forced expiratory volume at first second to forced vital capacity (FEVl/FVC), and forced expiratory volume at first second to predicted value (FEV1% predicted value) compared to those in the control group. This difference was statistically significant (P &lt; 0.05). There was a statistically significant (P &lt; 0.05) improvement in clinical efficacy between the observation group and the control group. In neither group did any patients stop taking the medication due to unwanted side effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A noninvasive ventilator combined with tiotropium bromide and piperacillin has accurate efficacy in the treatment of patients with chronic respiratory failure, which can improve the indexes of arterial blood gas and lung function, reduce inflammatory response, promote disease recovery an","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"101"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}