European Journal of Clinical Nutrition最新文献

{"title":"From dietary-pattern discovery to precision nutrition equity in type 2 diabetes","authors":"Mehak Garg, Rajesh Prasad Jayaswal, Rama Kumari Badyal","doi":"10.1038/s41430-026-01771-w","DOIUrl":"10.1038/s41430-026-01771-w","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 8","pages":"864-865"},"PeriodicalIF":3.2,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of okara and biovalorised okara consumption on postprandial amino acid response: a crossover randomised controlled trial","authors":"Delia Pei Shan Lee, Ian En Kai Mak, Genevieve Xin Yin Leong, Xiangning Liu, Jung Eun Kim","doi":"10.1038/s41430-026-01769-4","DOIUrl":"10.1038/s41430-026-01769-4","url":null,"abstract":"Okara is a protein-rich food by-product that can be biovalorised with Rhizopus oligosporus to improve its protein digestibility and quality. This study investigated postprandial circulating amino acid changes following okara and biovalorised okara biscuits consumption in middle-aged and older Singaporean adults. Participants of the crossover study (n = 15) undertook 3 separate 2-h meal tolerance test with 100 g of control biscuits (C), biovalorised okara biscuits (RO), and autoclaved okara biscuits (AOK). The same recipe was applied across all biscuits, but with 20% wheat flour substitution for RO and AOK with the respective okara. Total and free amino acids of the biscuits and circulating free amino acids of the participants were analysed by cation-exchange chromatography. Incremental area under curve (iAUC) and peak concentrations of amino acids were assessed, with results presented as mean [95% confidence interval]. While total biscuit amino acid content showed significantly greater quantities for RO and AOK compared to C, free amino acid content (nmol/g) was in the order of C < AOK < RO. Amino acid iAUC had no significant difference, as demonstrated with total amino acids iAUC (μmol/L·min) (P = 0.568, C: 23649 [13738, 33560], RO: 23284 [13374, 33195] & AOK: 17257 [7346, 27168]). Amino acid digestion and absorption did not differ between okara-containing and control biscuits at the levels consumed in this study, potentiating the need for higher protein dosages, larger sample sizes, and longer trial durations for detecting discernable improvements. This trial was registered under www.clinicaltrial.gov (NCT03978104, 25 May 2019).","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 8","pages":"772-780"},"PeriodicalIF":3.2,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-026-01769-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle mass is not compositionally uniform: the role of fluid compartments in health and performance monitoring.","authors":"Karl E Friedl, Analiza M Silva, Audrey Bergouignan, Yosuke Yamada, Adam W Potter","doi":"10.1038/s41430-026-01770-x","DOIUrl":"https://doi.org/10.1038/s41430-026-01770-x","url":null,"abstract":"<p><p>Skeletal muscle mass (SMM) is a central determinant of metabolic health, physical function, and resilience across the lifespan, yet its assessment is often confounded by the assumption that fat-free mass is compositionally uniform and stably hydrated. This narrative review synthesizes discussions from the 12th International Symposium on In Vivo Body Composition Studies and integrates evidence from aging, chronic energy deficit, disuse/microgravity, resistance training, and anabolic interventions to examine how intracellular and extracellular fluid compartments influence the interpretation of muscle mass and quality. We highlight that declines in muscle quality, reflected by loss of intracellular water and reduced cellular integrity, frequently precede measurable losses in muscle quantity and are more closely linked to functional impairment than bulk skeletal mass. Dual-energy X-ray absorptiometry, while valuable for population studies, cannot distinguish water from protein or intracellular from extracellular compartments and therefore may overestimate anabolic gains in fluid-retentive states or underestimate clinically meaningful muscle loss when extracellular water is preserved or expanded. Multi-frequency bioelectrical impedance techniques, including MF-BIA and BIS, complement structural methods by resolving total, extracellular, and intracellular water and by providing indices of cellular integrity, such as phase angle, that reflect muscle quality. We conclude that hydration-sensitive interpretation is essential for accurate assessment of skeletal muscle under physiological stress.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public health nutrition in India","authors":"Rebecca Kuriyan,&nbsp;Mario J. Soares","doi":"10.1038/s41430-026-01772-9","DOIUrl":"10.1038/s41430-026-01772-9","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 6","pages":"549-550"},"PeriodicalIF":3.2,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-026-01772-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From counting to caring: leveraging integrated data systems to improve child health care and maternal health care in Haryana, India","authors":"Rakesh Gupta","doi":"10.1038/s41430-026-01767-6","DOIUrl":"10.1038/s41430-026-01767-6","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 6","pages":"561-565"},"PeriodicalIF":3.2,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of digital anthropometric measurements during pregnancy: a longitudinal study","authors":"Sophia Ramirez,&nbsp;Jasmine Brown,&nbsp;Ryan Yang,&nbsp;Marianna Deynzer,&nbsp;Gabriela Lemos,&nbsp;Cassidy McCarthy,&nbsp;Sara Dube,&nbsp;John Virostko,&nbsp;Isaiah Janumala,&nbsp;Amy R. Nichols,&nbsp;Rachel Rickman,&nbsp;Saralyn F. Foster,&nbsp;Michelle Cassidy,&nbsp;Steven B. Heymsfield,&nbsp;Elizabeth M. Widen","doi":"10.1038/s41430-026-01763-w","DOIUrl":"10.1038/s41430-026-01763-w","url":null,"abstract":"Maternal anthropometric changes are rapid during pregnancy and reflect increments in maternal and fetal tissues. These dynamic changes in body composition and shape during pregnancy are associated with maternal and fetal outcomes and are often monitored with simple tools such as a flexible tape for quantifying selected circumferences. The current study aim was to evaluate the hypothesis that circumferential measures of maternal body size and shape acquired with a 3D-optical imaging system will correlate, be accurate, and agree closely with ground-truth estimates made with a flexible tape by trained staff. 3D-optical scans and flexible tape measurements were acquired at 15-, 25-, and 35-weeks of gestation in 57, 41, and 35 participants, respectively. 3D avatars obtained at each time point were analyzed for waist (two sites), hip, mid-upper arm, mid-thigh, and calf circumferences. 3D-optical and flexible tape measurements were compared using linear regression analyses (r, r 2s), mean absolute errors (MAEs), root-mean square errors (RMSEs), concordance correlation coefficients (CCCs), and Bland-Altman plots. Overall, associations between 3D and conventional anthropometric measurements were strong (univariate linear regression r values, 0.80–0.98; p’s all &lt;0.001) with good corresponding accuracy and agreement at all five anatomic sites (MAEs, –8.5 to 0.8 cm; RMSEs, 0.61–9.94 cm; CCCs 0.6–1.0; small significant (p &lt; 0.05) bias was present at some sites/timepoints for some measures). Post hoc analyses revealed a potential basis for impact of advancing pregnancy on between-method differences. Strong associations, good accuracy, and close agreement with flexible tape circumference measurements, combined with feasible implementation, supports further development of 3D-optical technology as an alternative to conventional anthropometry for evaluating and monitoring body size, shape, and composition over the course of pregnancy.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 8","pages":"833-845"},"PeriodicalIF":3.2,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-026-01763-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross-sectional and prospective associations between time-restricted eating and cardiometabolic health in community-dwelling adults: A systematic review and meta-analysis of observational studies","authors":"Viktoria Feit,&nbsp;Norbert Schmitz,&nbsp;Katharina Knaub,&nbsp;Lea-Marie Schick,&nbsp;Isabelle Mack,&nbsp;Mahdieh Shojaa","doi":"10.1038/s41430-026-01755-w","DOIUrl":"10.1038/s41430-026-01755-w","url":null,"abstract":"Well-established cardiometabolic disease (CMD) prevention strategies emphasize maintaining a balanced diet, regular physical activity, and a normal weight. The role of time-restricted eating (TRE; ≤12 h daily eating window) in improving cardiometabolic health remains elusive. This systematic review and meta-analysis of observational studies investigated the associations between TRE and cardiometabolic health in adults. We systematically searched PubMed, the Cochrane Library, Web of Science, and CINAHL for observational studies examining the association between TRE and cardiometabolic markers in adults for all articles published up to January 13, 2025. Risk of bias was assessed using the NIH Quality Assessment Tool. Qualitative and random-effects meta-analyses were performed if ≥3 studies reported the same outcome; otherwise, results were summarized narratively. 12 cross-sectional and 6 cohort studies were included. Meta-analysis of cross-sectional studies showed no significant association between TRE and abdominal obesity (OR = 0.96; 95% CI: 0.86–1.07; I² = 59%), metabolic syndrome (OR = 1.04; 95% CI: 0.90–1.19; I² = 32%), elevated blood pressure/hypertension (OR = 1.04; 95% CI: 0.971.12; I² = 0%), reduced high-density lipoprotein cholesterol (OR = 0.94; 95% CI: 0.83–1.06; I² = 78%), elevated triglycerides (OR = 1.06; 95% CI: 0.99–1.14; I² = 0%), and prediabetes/type 2 diabetes mellitus (OR = 1.04; 95% CI: 0.96–1.12; I² = 50%). Due to insufficient data, no conclusions could be drawn about prospective associations. To date, cross-sectional data have not consistently demonstrated associations between TRE and cardiometabolic health in community-dwelling adults. Until stronger real-world evidence emerges, the priority should remain on established CMD prevention strategies. PROSPERO registration number: CRD42023390410.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 8","pages":"747-762"},"PeriodicalIF":3.2,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-026-01755-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbial signatures across nutritional status in Indian school-aged children: a qPCR-based case-control study","authors":"Jovis Jacob,&nbsp;Samarasimha N. Reddy,&nbsp;Venkatesh Kaliaperumal,&nbsp;JJ Babu Geddam,&nbsp;Kalashikam Rajender Rao,&nbsp;Karthikeyan Ramanujam,&nbsp;ER Nandeep,&nbsp;Athira Anilkumar Sudharma","doi":"10.1038/s41430-026-01766-7","DOIUrl":"10.1038/s41430-026-01766-7","url":null,"abstract":"Gut dysbiosis is a characteristic feature of malnutrition; however, a standardized microbial index for assessing gut health in community settings is lacking. This study aimed to assess the relative abundance of key bacterial communities in underweight, obese, and normal-weight children and adolescents using quantitative polymerase chain reaction (qPCR). We conducted a 12-month case-control study (February 2023-February 2024) in Hyderabad, India, involving 70 children aged 8–18 years. Participants were categorized as thin (Body Mass Index-for-age Z-score (BAZ) &lt; -2 SD; n = 23), normal-weight (n = 24), or obese (BAZ &gt; +2 SD; n = 23). Socio-demographic and anthropometric data were collected. Fecal samples were analyzed for relative abundance of target bacteria species using quantitative PCR (Roche Light Cycler 480). Conditional and unconditional logistic regression models were used to assess associations between bacterial abundance and nutritional status. Obese children had higher odds of Lactobacillus spp. (matched odds ratio [mOR] 12.92, 95% CI 1.48–112.86; p = 0.02) and Faecalibacterium prausnitzii (mOR 5.49, 95% CI 1.06–28.49; p = 0.04) compared with normal-weight children. Bacteroides spp. were more abundant in obese (mOR 11.10, 95% CI 1.15–107.20; p = 0.04) and thin children (mOR 8.10, 95% CI 0.87–75.99; p = 0.07). In contrast, Bifidobacterium spp. showed lower abundance in both obese (mOR 0.006, 95% CI 0.00–0.07) and thin children (mOR 0.54, 95% CI 0.01–0.47) relative to normal-weight peers. This study identified distinct patterns of gut bacterial dysbiosis, characterized by altered relative abundances of Lactobacillus, Faecalibacterium prausnitzii, Bacteroides, and Bifidobacterium, among children and adolescents across different nutritional statuses. These microbial signatures may serve as potential early indicators of malnutrition-related dysbiosis and warrant further investigation.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 6","pages":"625-632"},"PeriodicalIF":3.2,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative research: a needed but neglected form of inquiry in nutrition","authors":"Manjulika Vaz","doi":"10.1038/s41430-026-01762-x","DOIUrl":"10.1038/s41430-026-01762-x","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 6","pages":"557-560"},"PeriodicalIF":3.2,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food fortification in India: evidence, implementation and future directions to reduce iron and other micronutrient deficiencies","authors":"Prashanth Thankachan,&nbsp;Sumathi Swaminathan,&nbsp;Sumithra Muthayya","doi":"10.1038/s41430-026-01761-y","DOIUrl":"10.1038/s41430-026-01761-y","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"80 6","pages":"551-556"},"PeriodicalIF":3.2,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}