Bárbara Chaves Santos, Bruna Cherubini Alves, Ana Luisa Ferreira Fonseca, Samanta Catherine Ferreira, Yani Gláucia Gomide Mizubuti, Camila Saueressig, Ramona Souza da Silva Baqueiro Boulhosa, Lívia Alves Amaral Santos, Carla de Magalhães Cunha, Andre Castro Lyra, Lucivalda Pereira Magalhães Oliveira, Rosângela Passos de Jesus, Fernando Gomes Romeiro, Valesca Dall'Alba, Vivian Cristine Luft, Maria Isabel Toulson Davisson Correia, Lívia Garcia Ferreira, Lucilene Rezende Anastácio
{"title":"肝硬化患者握力的截止点：一项多中心研究。","authors":"Bárbara Chaves Santos, Bruna Cherubini Alves, Ana Luisa Ferreira Fonseca, Samanta Catherine Ferreira, Yani Gláucia Gomide Mizubuti, Camila Saueressig, Ramona Souza da Silva Baqueiro Boulhosa, Lívia Alves Amaral Santos, Carla de Magalhães Cunha, Andre Castro Lyra, Lucivalda Pereira Magalhães Oliveira, Rosângela Passos de Jesus, Fernando Gomes Romeiro, Valesca Dall'Alba, Vivian Cristine Luft, Maria Isabel Toulson Davisson Correia, Lívia Garcia Ferreira, Lucilene Rezende Anastácio","doi":"10.1038/s41430-024-01563-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.</p><p><strong>Methods: </strong>This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.</p><p><strong>Results: </strong>The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0-63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.</p><p><strong>Conclusion: </strong>These cutoff points could be used to identify patients with a higher mortality risk.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study.\",\"authors\":\"Bárbara Chaves Santos, Bruna Cherubini Alves, Ana Luisa Ferreira Fonseca, Samanta Catherine Ferreira, Yani Gláucia Gomide Mizubuti, Camila Saueressig, Ramona Souza da Silva Baqueiro Boulhosa, Lívia Alves Amaral Santos, Carla de Magalhães Cunha, Andre Castro Lyra, Lucivalda Pereira Magalhães Oliveira, Rosângela Passos de Jesus, Fernando Gomes Romeiro, Valesca Dall'Alba, Vivian Cristine Luft, Maria Isabel Toulson Davisson Correia, Lívia Garcia Ferreira, Lucilene Rezende Anastácio\",\"doi\":\"10.1038/s41430-024-01563-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.</p><p><strong>Methods: </strong>This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.</p><p><strong>Results: </strong>The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0-63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.</p><p><strong>Conclusion: </strong>These cutoff points could be used to identify patients with a higher mortality risk.</p>\",\"PeriodicalId\":11927,\"journal\":{\"name\":\"European Journal of Clinical Nutrition\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-01-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Clinical Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41430-024-01563-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41430-024-01563-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Cutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study.
Objectives: This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.
Methods: This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.
Results: The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0-63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.
Conclusion: These cutoff points could be used to identify patients with a higher mortality risk.
期刊介绍：
The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion.
Topics of interest include but are not limited to:
Nutrition and Health (including climate and ecological aspects)
Metabolism & Metabolomics
Genomics and personalized strategies in nutrition
Nutrition during the early life cycle
Health issues and nutrition in the elderly
Phenotyping in clinical nutrition
Nutrition in acute and chronic diseases
The double burden of ''malnutrition'': Under-nutrition and Obesity
Prevention of Non Communicable Diseases (NCD)
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