European Journal of Clinical Nutrition最新文献

{"title":"Food and nutrition insecurity and clinical and anthropometric indicators in individuals with cancer eligible for radiotherapy","authors":"Panera Charnioski de Andrade, Aniely Fernanda de Oliveira Hinokuma, Doroteia Aparecida Höfelmann","doi":"10.1038/s41430-025-01593-2","DOIUrl":"10.1038/s41430-025-01593-2","url":null,"abstract":"to analyze the association between food and nutrition insecurity (FNI) and sociodemographic, clinical, and anthropometric indicators in individuals with cancer eligible for curative radiotherapy. Study with the collection of sociodemographic and clinical data, and nutritional, anthropometric, and FNI assessment. Estimated Prevalence Ratio (PR) and 95% confidence intervals (95% CI) of FNI and exposure variables using the Poisson regression model with robust variance. 252 individuals were evaluated, 51.2% female, 60.7% elderly, 40.1% with breast or uterine cancer, 27.8% with urological cancer, 18.2% with head and neck cancer, and 7.5% with difficulty acquiring an enteral diet or nutritional supplement. The prevalence of FNI was 17.9%, 6.4% being moderate and 3.6% severe. FNI was less frequent in the high-income tertile (PR = 0,38; 95% CI: 0,18–0,79), and in individuals with urological tumors (PR = 0.12; 95% CI: 0.04–0.37), while higher prevalences were identified in non-white individuals (PR = 1,82; 95% CI: 1.01–3.28) among those with stage IV tumor (PR = 1.42; 95% CI: 1.03–1.95), with severe weight loss (PR = 2.99; 95% CI: 1.75–4.82), severely malnourished (PR = 2.58; 95% CI: 1.34–4.95) and bedridden (PR = 5.54; 95% CI: 2.72–11.29). Additionally, a higher prevalence of FNI associated with a reduction in usual food consumption (PR = 2.09; 95% CI: 1.24–3.54), the need to modify the consistency of the diet (PR = 3.45; 95% CI: 2.11–5.67), use of caloric supplements (PR = 2.07; 95% CI: 1.17–3.69) or enteral feeding (PR = 3.46; 95% CI: 2.01–5.94). One in five individuals with cancer presented FNI associated with socioeconomic and nutritional vulnerability in the radiotherapy pre-treatment phase.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"690-697"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of low vitamin D status in the Czech Republic: a retrospective study of 119,925 participants","authors":"Drahomira Holmannova, Pavel Borsky, Jan Kremlacek, Jan Krejsek, Lenka Hodacova, Anabela Cizkova, Zdenek Fiala, Lenka Borska","doi":"10.1038/s41430-025-01587-0","DOIUrl":"10.1038/s41430-025-01587-0","url":null,"abstract":"Given the high worldwide prevalence of vitamin D deficiency and its role in numerous diseases affecting mortality and morbidity, this study seeks to determine the prevalence of low 25-hydroxyvitamin D levels in the Czech Republic, where population-level data are currently lacking. This retrospective study utilized a large dataset to analyze 25-hydroxyvitamin D levels over an extended period. We analyzed data from 119,925 individuals aged 0–100 years categorizing them as sufficient (75–250 nmol/L), insufficient (50–75 nmol/L), or deficient (<50 nmol/L). We also examined levels of CRP, homocysteine, and their correlations with 25-hydroxyvitamin D levels across age groups. Age, sex, sampling month, sunlight exposure (monthly and annual), and influenza virus positivity were assessed for their relationship with the 25-hydroxyvitamin D levels. The study found a high prevalence of 25-hydroxyvitamin D inadequacy, with sufficient levels observed in 65.6% of infants (0–12 months). The lowest prevalence of sufficiency was in the 6–15 years (19.2%) and 16–30 years (22.1%) groups. The highest deficiency prevalence was in the 91–100 years group (51.8%). 25-hydroxyvitamin D levels in all age groups and both sexes correlated with all selected parameters. Lower sun exposure, higher flu virus positivity, male gender, and elevated homocysteine and CRP levels were negatively correlated with 25-hydroxyvitamin D levels. The prevalence of 25-hydroxyvitamin D inadequacy in the Czech Republic is high. It is advisable to consider testing, monitoring, and providing medical recommendations for vitamin D supplementation as part of health prevention strategies in the general population.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"641-652"},"PeriodicalIF":3.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41430-025-01587-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nighttime snacking during pregnancy and postpartum depression among community-dwelling pregnant women: a prospective cohort study","authors":"Tohru Kobayashi, Reiji Kojima, Emiko Okada","doi":"10.1038/s41430-025-01592-3","DOIUrl":"10.1038/s41430-025-01592-3","url":null,"abstract":"The effect of the frequency of nighttime snacking during pregnancy on postpartum depression (PPD) remains unclear. This prospective cohort study aimed to explore the association between the frequency of nighttime snacking during pregnancy and the incidence of PPD. This study included 609 community-dwelling pregnant women who were recruited between July 2019 and July 2022. Data on the frequency of nighttime snacking and sociodemographic, economic, and lifestyle factors were obtained using self-administered questionnaires. Data on dietary intake were obtained using a validated brief self-administered diet history questionnaire. PPD was assessed using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS). The incidence of PPD (EPDS score of ≥9) based on the frequency of nighttime snacking was analyzed using multiple logistic regression analysis. After adjusting for potential confounding factors, the odds ratio (OR) of PPD in participants who had a frequency of nighttime snacking 3 times/week or more compared with those who had a frequency of nighttime snacking less than 1 time/week was 2.59 (95% confidence interval, 1.14–5.86). Sensitivity analysis was repeated for the excluded participants with depressive symptoms during pregnancy, yielding similar results. The OR of PPD in those who indulged in nighttime snacking ≥3 times/week was the highest (2.81; 95% confidence interval, 1.13–6.96). The present study clarified the association between the frequency of nighttime snacking and PPD. Further studies with large and diverse samples are needed to overcome any potential selection bias.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"653-659"},"PeriodicalIF":3.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of appetite stimulants on growth parameters in children with cystic fibrosis","authors":"Birce Sunman, Nagehan Emiralioglu, Hayriye Hizarcioglu-Gulsen, Didem Alboga, Raziye Atan, Burcu Capraz Yavuz, Ersin Gumus, Hulya Demir, Inci Nur Saltik-Temizel, Hasan Ozen, Ebru Yalcin, Deniz Dogru, Uğur Özçelik","doi":"10.1038/s41430-025-01591-4","DOIUrl":"10.1038/s41430-025-01591-4","url":null,"abstract":"Malnutrition is prevalent among children with cystic fibrosis (CF), often resulting from frequent pulmonary exacerbations and intestinal malabsorption. In addition to providing sufficient calorie intake through enteral formulas, appetite stimulants may help address nutritional deficiencies and improve overall prognosis. This retrospective study included children who received cyproheptadine (CH) as an appetite stimulant for at least three consecutive months. Data on CH-related adverse effects, z-scores for weight, height, body mass index (BMI), and percentage of forced expiratory volume in 1 s (FEV1%) were collected from medical records. Z-scores of growth parameters were calculated at baseline (CH initiation), three months before baseline, and three and six months after treatment. The study included 45 children with a mean age of 11 years. One patient was on modulator therapy, one was pancreatic sufficient, and another one had diabetes. Only one patient was using enteral supplementation simultaneously with CH. Significant improvements in weight and BMI z-scores were observed from baseline to three months of CH therapy (p = 0.004 and p = 0.006, respectively), with no significant changes noted in the three months before treatment. A modest increase in weight and BMI z-scores was seen from three to six months of therapy. Additionally, FEV1 z-scores significantly increased from baseline to three months of therapy, with no further improvement observed in the subsequent three months. Six months of CH therapy was associated with significant improvements in weight and BMI z-scores, particularly within the first three months. No adverse effects were reported. Given the deceleration in the rate of increase in anthropometric z-scores from the third to sixth month, a three-month duration of CH therapy appears to be optimal and sufficient for children with CF.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"685-689"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate-to-vigorous and light-intensity aerobic exercise yield similar effects on food reward, appetitive responses, and energy intake in physically inactive adults.","authors":"Shu-Shih Hsieh, Angelos Bala, Kapris Layzell, Qanita Fatima, Clarciya Pushparajah, Rebecca K Maguire, Yung-Chih Chen, Graham Finlayson, Judith E Allgrove","doi":"10.1038/s41430-025-01574-5","DOIUrl":"10.1038/s41430-025-01574-5","url":null,"abstract":"<p><strong>Objective: </strong>To examine the effect of acute aerobic exercise at moderate-to-vigorous and light intensity on food reward, appetite sensation, and energy intake (EI) in physically inactive adults.</p><p><strong>Methods: </strong>Twenty inactive, healthy adults (mean age: 21 ± 3 years) completed two trials (i.e. moderate-to-vigorous and light-intensity exercise) in a randomised, crossover design. Participants performed a 40-min cycling bout at either 50% or 20% peak power output in a counterbalanced order. Before and after exercise bouts, liking and wanting for fat and sweet/savoury categories of food were assessed by the Leeds Food Preference Questionnaire, along with subjective ratings of appetite and state food cravings. EI was evaluated by ad libitum meals following exercise bouts.</p><p><strong>Results: </strong>Results showed increased implicit wanting for high-fat relative to low-fat foods (p = .04, d_rm = 0.50) and savoury relative to sweet foods following exercise bouts (p = .04, d_rm = -0.49) without intensity-specific effects. Exercise bouts also led to increased subjective appetite (p < 0.001, η²_p = 0.60) and state food cravings (p = 0.001, η²_p = 0.44) without intensity-specific differences. There was no difference between exercise intensities on absolute EI, whereas relative EI was lower after moderate-to-vigorous exercise relative to light exercise (p < 0.001, d_rm = -1.56).</p><p><strong>Conclusion: </strong>Acute aerobic exercise, regardless of intensity, may lead to increased wanting for high-fat relative to low-fat and savoury relative to sweet-tasting foods, as well as enhanced appetite sensation and food cravings in physically inactive adults. Moderate-to-vigorous exercise does not induce additional energy intake relative to light exercise.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of high protein intakes during energy restriction on body composition, energy metabolism and physical performance in recreational athletes","authors":"Mikael F. Kanaan,&nbsp;Samir Nait-Yahia,&nbsp;Éric Doucet","doi":"10.1038/s41430-025-01585-2","DOIUrl":"10.1038/s41430-025-01585-2","url":null,"abstract":"Athletes employ weight loss practices to lower body fat and maintain fat-free mass (FFM). High protein diets have been shown to produce greater fat loss and retention of lean mass during periods of energy restriction (ER) in sedentary individuals with obesity, but less is known about the effects of high protein diets in trained individuals during ER. Although current recommendations for protein intake in active individuals are 1.2–1.7 g/kg, it is unclear whether higher intakes are necessary to maximize FFM retention and maximize physical performance in athletes undergoing periods of ER. Determine whether high protein intakes could maximize FFM retention and physical performance in trained individuals after a period of ER. Twenty-one college aged athletes underwent a 6-week 25% ER + 3-day full body resistance training. Participants were randomly assigned to a low (~1.2 g/kg), moderate (~1.6 g/kg) or high (~2.2 g/kg) protein intake. Baseline and post-intervention outcomes: Dual X-ray absorptiometry, isotopic water dilution, indirect calorimetry, dietary records and strength based physical testing. Significant reductions in body mass (p = 0.047) and fat mass (p = 0.04) with simultaneous increases in FFM (p = 0.037) were noted for all groups, with no protein intake effect. Significant increases in physical performance outcomes (5RM strength) were noted for most measures (p &lt; 0.05). Current protein intake recommendations of 1.2–1.7 g/kg appear sufficient for most athletes even during periods of ER to maintain FFM and physical performance.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 6","pages":"544-552"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41430-025-01585-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation between body mass index and target organ damage and the mediating role of blood pressure","authors":"Ionas Papassotiriou,&nbsp;Sotiria Spiliopoulou,&nbsp;Damianos Dragonas,&nbsp;Nefeli Tsoutsoura,&nbsp;Eleni Korompoki,&nbsp;Efstathios Manios","doi":"10.1038/s41430-025-01573-6","DOIUrl":"10.1038/s41430-025-01573-6","url":null,"abstract":"The relationship between obesity and blood pressure (BP) is well known, but limited data exists regarding its relationship with target organ damage (TOD). Therefore, this study aimed to examine the relationship between body mass index (BMI) and TOD and the mediating role of BP. 2555 adults (52.0% women) who visited a local Hypertension Unit with valid measures on weight, height, 24 h ambulatory BP monitoring, office BP measurements, echocardiography, carotid ultrasonography and blood creatinine levels, included in this cross-sectional study. BMI was used to categorize participants as having normal weight (&lt; 25 kg/m2), overweight (25–29.9 kg/m2) or obesity (≥ 30 kg/m2). The intima-media thickness (IMT) of the common (CCA) and the internal (ICA) carotid artery, left ventricular mass (LVM), LVM index (LVMI) and estimated glomerular filtration rate (eGFR) were estimated and used as TOD indices. Linear regression models were used to examine the relationship between obesity and BP measurements or TOD, while structural equation modeling (SEM) for mediation analysis. Obesity was significantly related to 24-hour systolic BP (b = 3.72, 95%CI: 2.24–5.21, p &lt; 0.001), CCA-IMT (b = 0.04, 95%CI: 0.02–0.05, p &lt; 0.001), ICA-IMT (b = 0.03, 95%CI: 0.01–0.05, p = 0.020), and LVMI (b = 7.54, 95CI%: 4.25–10.83, p &lt; 0.001). The mediation analysis revealed that 24-hour systolic BP mediated by 27.9% the relationship between BMI and CCA-IMT, by 31.3% the relationship between BMI and ICA-IMT, and by 18.1% the relationship between BMI and LVMI. These results indicate that obesity is associated with indices of asymptomatic cardiac remodeling and vascular atherosclerosis, and systolic BP mediates these relationships.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"627-634"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable, planetary healthy dietary patterns are associated with lower 20-year incidence of cardiovascular disease: the ATTICA study (2002–2022)","authors":"Evangelia Damigou,&nbsp;Shauna M. Downs,&nbsp;Christina Chrysohoou,&nbsp;Fotios Barkas,&nbsp;Costas Tsioufis,&nbsp;Christos Pitsavos,&nbsp;Evangelos Liberopoulos,&nbsp;Petros P. Sfikakis,&nbsp;Demosthenes Panagiotakos","doi":"10.1038/s41430-025-01586-1","DOIUrl":"10.1038/s41430-025-01586-1","url":null,"abstract":"Nutrition epidemiology research scarcely focuses on the relationship between dietary patterns that are beneficial for both planet and human health. This study aimed to examine the association between adherence to a sustainable, planetary-healthy dietary pattern, i.e., the EAT-Lancet Reference Diet (EAT-LD), and 20-year cardiovascular disease (CVD) incidence, in a Mediterranean population. Τhe ATTICA study is a prospective cohort study with a baseline phase in 2002 and 3 consecutive follow-ups (in 2006, 2012, 2022). The EAT-Lancet Index (EAT-LI) and the MedDietScore scales were calculated based on previously published guidelines to assess the adherence to the respective dietary pattern. The current sample consisted of 1,988 Greek adults initially free-of-CVD at baseline. The development of a cardiovascular event was assessed throughout the 20-year period (WHO-ICD-10 classification). The 20-year incidence of CVD was 3600 cases/10,000 individuals (95%Confidence Interval-CI: 3506 to 3695/10,000). Median (interquartile range) values for EAT-LI and MedDietScore were 17 (6.2) out of possible 42 points and 27 (2.9) out of possible 55 points, respectively. Both diet scales were inversely associated with 20-year CVD incidence [Hazard Ratio-HR (95% CI) per 1 point (of possible 42 points) of EAT-LI: 0.83 (0.77–0.90) and per 1 point (of possible 55 points) of MedDietScore: 0.90 (0.84–0.93)]. Our findings highlight that diets that are good for planetary health, are also healthy for humans. Promoting diets that are culturally acceptable, economically viable, easily accessible, planet-friendly, and sustainable should be a key strategy for enhancing both public and planetary health.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 6","pages":"536-543"},"PeriodicalIF":3.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41430-025-01586-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval rope-skipping on cardiorespiratory fitness, body composition, and enjoyment in young adults.","authors":"Wachirawit Phongchin, Suthana Tingsabhat, Ravisara Trongjitpituk, Thitipat Reun-Arom, Eric Tsz-Chun Poon, Waris Wongpipit","doi":"10.1038/s41430-025-01575-4","DOIUrl":"https://doi.org/10.1038/s41430-025-01575-4","url":null,"abstract":"<p><strong>Background/objective: </strong>Rope skipping is a cost-effective, moderate-to-vigorous-intensity aerobic exercise. While high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) are known to improve cardiorespiratory fitness (CRF) in labs, their effects in free-living conditions with rope skipping in young adults are unclear. The purpose of the study was to examine the effects of HIIE and MICE using rope skipping on CRF, body composition, and enjoyment in young adults.</p><p><strong>Subjects/methods: </strong>Fifty-nine healthy adults (29 females; aged 21.7 ± 2.5 years) were randomly assigned to HIIE (9 × 2-min bouts at 80% HRmax with 1-min active recovery), MICE (30-min at 70% HRmax), or a non-exercise control group (CONT). HIIE sessions occurred three times weekly, MICE five times weekly, over 8 weeks. Maximal oxygen uptake (a measure of CRF) was assessed both before and after the intervention. Enjoyment was evaluated using the Physical Activity Enjoyment Scale following the first and final sessions.</p><p><strong>Results: </strong>After 8 weeks, both HIIE [48.4 (43.9, 52.9) mL/kg/min; mean (95%CI)] and MICE [47.2 (43.1, 51.1) mL/kg/min] groups showed significantly better CRF than pretest [43.8 (38.8, 48.8) mL/kg/min, p < 0.001, and 42.2 (38.1, 46.2) mL/kg/min, p < 0.001, respectively] and the CONT group [39.9 (37.0, 42.8) mL/kg/min, p < 0.001, η²p = 0.595]. Body composition did not differ among or within groups. Enjoyment levels also did not differ between or within exercise groups.</p><p><strong>Conclusion: </strong>HIIE and MICE using rope skipping similarly enhanced CRF and provided comparable enjoyment in young adults. HIIE could be a time-efficient alternative to MICE for those with limited exercise time.</p><p><strong>Clinical trial registration: </strong>TCTR20220314004, thaiclinicaltrials.org.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Gaps in the Vitamin B12 Deficiency 2024 NICE Guidelines: Highlighting the Need for Better Recognition, Diagnosis, and Management of Pernicious Anaemia","authors":"Alfie Thain,&nbsp;Kathryn Hart,&nbsp;Kourosh R. Ahmadi","doi":"10.1038/s41430-025-01583-4","DOIUrl":"10.1038/s41430-025-01583-4","url":null,"abstract":"The 2024 NICE guidelines on vitamin B12 deficiency have significant implications for the diagnosis and management of pernicious anaemia (PA), the commonest non-dietary cause of such deficiency. This perspective discusses the guidelines in relation to PA itself, suggests that clearer diagnostic protocols are required, and calls for clinician education to improve the patient journey for those with PA.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 7","pages":"607-610"},"PeriodicalIF":3.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41430-025-01583-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}