European Child & Adolescent Psychiatry最新文献

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Risk and protective factors for mental health problems in children and adolescents during the COVID-19 pandemic: results of the longitudinal COPSY study. COVID-19 大流行期间儿童和青少年心理健康问题的风险和保护因素:COPSY 纵向研究的结果。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-29 DOI: 10.1007/s00787-024-02604-6
F Zoellner, M Erhart, A-K Napp, F Reiss, J Devine, A Kaman, U Ravens-Sieberer
{"title":"Risk and protective factors for mental health problems in children and adolescents during the COVID-19 pandemic: results of the longitudinal COPSY study.","authors":"F Zoellner, M Erhart, A-K Napp, F Reiss, J Devine, A Kaman, U Ravens-Sieberer","doi":"10.1007/s00787-024-02604-6","DOIUrl":"https://doi.org/10.1007/s00787-024-02604-6","url":null,"abstract":"<p><p>The COVID-19 pandemic has had profound effects on the mental health of children and adolescents worldwide, exacerbating existing challenges and introducing new stressors. This paper explores the impact of risk and protective factors on the mental well-being of young individuals during the pandemic. Using data from the German nationwide, population-based, longitudinal COPSY study (n = 2,471, girls: 50.0%, age 7-17 years) spanning nearly three years, this study investigates how factors such as gender, age, parental education, parental depressive symptoms, family cohesion, and social support influence mental health. Mental health problems were assessed using the Strengths and Difficulties Questionnaire (SDQ). Latent growth analysis and structural equation modeling were employed to analyze cross-sectional and longitudinal data collected at five measurement points (initial response rate: 46.8%). Findings revealed that boys and younger children are at a higher risk for mental health problems. Additionally, low parental education, single parenthood, parental burden due to the pandemic and parental depressive symptoms were significantly linked with mental health problems in children. Conversely, personal resources, family cohesion, and social support were associated with less symptoms. Family cohesion additionally buffered against the negative impact of parental depressive symptoms. The study underscores the importance of multi-level interventions that consider individual, familial, and societal factors in promoting positive mental health outcomes among children and adolescents during challenging times. Continued research and collaborative efforts are needed to develop evidence-based strategies for supporting the resilience of young individuals in the face of future adversities.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018. 1990年至2018年间瑞典16岁学生学习成绩与内化障碍之间的关系。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-29 DOI: 10.1007/s00787-024-02597-2
Björn Högberg, Mattias Strandh, Solveig Petersen, Karina Nilsson
{"title":"Associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018.","authors":"Björn Högberg, Mattias Strandh, Solveig Petersen, Karina Nilsson","doi":"10.1007/s00787-024-02597-2","DOIUrl":"10.1007/s00787-024-02597-2","url":null,"abstract":"<p><strong>Background: </strong>Rising rates of internalizing disorders and rising rates of school failure among adolescents are growing concerns. Despite the strong association between academic achievement and internalizing disorders, possible links between these two trends have not been investigated. Thus, the aim of this study was to investigate the development of the cross-sectional associations between academic achievement and internalizing disorders in Swedish students aged 16 years between 1990 and 2018.</p><p><strong>Methods: </strong>Register data on specialist psychiatric care and prescriptions of psycholeptic and psychotropic drugs were linked to data on students' school grades in the last year of compulsory school. The total sample size was 3,089,674 students. Logistic regression models with internalizing disorders as the dependent variable, and graduation year and academic achievement as independent variables, were estimated.</p><p><strong>Results: </strong>Throughout the period, there was a strong negative association between academic achievement and internalizing disorders. Low-achieving students had by far the highest risks of internalizing disorders. In absolute terms, the increase in internalizing disorders was clearly largest for low-achieving students. The relative risks for low-achieving compared to higher achieving students increased between 1990 and 2010 and declined after 2010.</p><p><strong>Conclusions: </strong>This study found consistently large, and at least until 2010 growing, achievement-related inequalities in internalizing disorders among Swedish adolescents between 1990 and 2018, with the lowest achieving students having disproportionally high risks. The increasingly pronounced concentration of internalizing disorders in the lowest rungs of the achievement distribution suggests that preventive interventions should focus on supporting this doubly disadvantaged group of students.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mental health of European adolescents with vs. without a migration background (2013-2024)-a systematic review. 有移民背景与无移民背景欧洲青少年的心理健康(2013-2024 年)--系统回顾。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-28 DOI: 10.1007/s00787-024-02589-2
Suze Lievrouw, Inez Myin-Germeys, Robin Achterhof
{"title":"The mental health of European adolescents with vs. without a migration background (2013-2024)-a systematic review.","authors":"Suze Lievrouw, Inez Myin-Germeys, Robin Achterhof","doi":"10.1007/s00787-024-02589-2","DOIUrl":"https://doi.org/10.1007/s00787-024-02589-2","url":null,"abstract":"<p><p>Migration has been associated with both adverse and potentially beneficial mental health outcomes, with varying impacts on adolescents. With great flux in European migrations streams, an update is required of its effects on adolescent mental health. This systematic review provides an overview of the relationship between migration background (first, second, and third generation) and psychopathology for youth aged 12-25 living in Europe. A systematic search based on four concepts (i.e., mental health, human migration, European Union, and adolescents) carried out on Pubmed, Embase, Web of Science, Scopus, PsycArticles and Proquest Central led to the retrieval of 51 relevant studies published between April 2013 and August 2024. The present study was conducted and reported according to the PRISMA 2020 Checklist. Our systematic search found some evidence for the increased risk of mental health problems in people with a migration background, showing overall elevated risks for the development of psychotic experiences, psychosomatic symptoms, eating disorders, substance-related disorders and suicidal actions in the migrant population. Little consistent high-quality evidence was found for the effects of migration on any other mental health problems. Identified risk factors for adolescents with a migration background included being a first-generation migrant, low socio-economic status, low ethnic identification, and perceived discrimination. Results are mixed, but suggest that, overall, adolescents with a migration background have a mental health disadvantage. Intervention and prevention programs can be strengthened, not only by focusing more specifically on adolescent migrants, but also by considering the different contexts and experiences that put them at increased risk.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrence of internet gaming disorder in Korean adolescents: a 24-month follow-up study. 韩国青少年网络游戏障碍的复发:一项为期24个月的跟踪研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-28 DOI: 10.1007/s00787-024-02598-1
Sun-Jin Jo, Hae Kook Lee, Hans-Jürgen Rumpf, Hyunsuk Jeong, Hyeon Woo Yim
{"title":"Recurrence of internet gaming disorder in Korean adolescents: a 24-month follow-up study.","authors":"Sun-Jin Jo, Hae Kook Lee, Hans-Jürgen Rumpf, Hyunsuk Jeong, Hyeon Woo Yim","doi":"10.1007/s00787-024-02598-1","DOIUrl":"https://doi.org/10.1007/s00787-024-02598-1","url":null,"abstract":"<p><p>Many adolescents use internet games, and some of them experience psychological and social difficulties due to excessive gaming. Although there have been many studies on the onset and associated factors of internet gaming disorder (IGD) , research focusing specifically on its relapse is scarce. Considering that addictive disorders often have a chronic course with frequent relapse, this study prospectively observed adolescents from the general population to explore IGD recurrence rate and associated factors of recurrence. In this prospective cohort study, from 1587 middle school gaming users, 1452 (91.5%) were followed up at 12 months and 24 months. The results showed that the cumulative recurrence rate of IGD was 16.1%, which was higher than the initial incidence rate of 3.6%; the adjusted incidence rate ratio was 2.43 with 95% CI 1.21-4.87 (P = 0.012). In addition, starting internet gaming before entering primary school was associated with a higher risk of relapse (P = 0.004). Limiting internet gaming for children before they enter primary school may reduce the risk of relapse of IGD that they may encounter during their adolescent years.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional connectivity density of brain in children with primary nocturnal enuresis: results from a resting-state fMRI study. 原发性夜间遗尿症儿童大脑功能连接密度:静息态 fMRI 研究结果。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-24 DOI: 10.1007/s00787-024-02586-5
Yang Zhang, Yaqin Di, Jing Chen, Xin Du, Jinqiu Li, Qiaohui Liu, Chunxiang Wang, Quan Zhang
{"title":"Functional connectivity density of brain in children with primary nocturnal enuresis: results from a resting-state fMRI study.","authors":"Yang Zhang, Yaqin Di, Jing Chen, Xin Du, Jinqiu Li, Qiaohui Liu, Chunxiang Wang, Quan Zhang","doi":"10.1007/s00787-024-02586-5","DOIUrl":"https://doi.org/10.1007/s00787-024-02586-5","url":null,"abstract":"<p><p>Primary nocturnal enuresis (PNE) is a disease characterized by involuntary urination during sleep after the age of five, causing inconvenience and psychological burden to children and their families. The onset of PNE is related to many factors, and in recent years, delayed central nervous system maturation has been considered one of the important causes of PNE. Previous studies have demonstrated functional changes in multiple brain regions in children with PNE. However, these studies either focused on changes in local brain regions or the functional connection (FC) between specific brain regions, and there is currently a lack of research on the whole brain FC in children with PNE. This study analyzed functional connectivity density (FCD) across the entire brain based on voxels and comprehensively evaluated the global FCD (gFCD), local FCD (lFCD), and long-range FCD (lrFCD). Decreased gFCD and lFCD were found in the left temporal lobe and the right posterior cerebellum in the children with PNE compared with the HC. The FCD values in these regions were negatively correlated with the scores of hyperactivity/impulsivity in the children with PNE. This study may help to reveal the neural mechanisms underlying the onset of PNE in children from a new perspective.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: An investigation of the acute effects of aerobic exercise on executive function and cortical excitability in adolescents with attention deficit hyperactivity disorder (ADHD). 更正:有氧运动对注意力缺陷多动障碍(ADHD)青少年执行功能和大脑皮层兴奋性的急性影响调查。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-24 DOI: 10.1007/s00787-024-02583-8
Hsiao-I Kuo, Jia-Ling Sun, Michael Nitsche, Jung-Chi Chang
{"title":"Correction: An investigation of the acute effects of aerobic exercise on executive function and cortical excitability in adolescents with attention deficit hyperactivity disorder (ADHD).","authors":"Hsiao-I Kuo, Jia-Ling Sun, Michael Nitsche, Jung-Chi Chang","doi":"10.1007/s00787-024-02583-8","DOIUrl":"10.1007/s00787-024-02583-8","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of screen exposure to stress, learning, cognitive and language performance in children. 屏幕暴露与儿童压力、学习、认知和语言表现的相关性。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-23 DOI: 10.1007/s00787-024-02593-6
Andrea Hahnefeld, Monika Fink, Saskia Le Beherec, Marie Anna Baur, Katharina Bernhardt, Volker Mall
{"title":"Correlation of screen exposure to stress, learning, cognitive and language performance in children.","authors":"Andrea Hahnefeld, Monika Fink, Saskia Le Beherec, Marie Anna Baur, Katharina Bernhardt, Volker Mall","doi":"10.1007/s00787-024-02593-6","DOIUrl":"10.1007/s00787-024-02593-6","url":null,"abstract":"<p><p>The omnipresence of mobile screens and convenience to operate them has led to increased screen time for young children whereas the sequelae of prolonged exposure are not known yet. 70 refugee children (RG) and 111 children of a clinical comparison group (CG) from a help-seeking population (age: M = 5.10; SD = 1.11; range 3.00-6.97 years) were assessed concerning their amount of daily screen exposure time in relation to parental education and distress. Salivary cortisol was collected as a marker for biological stress and children were tested concerning learning performance, non-verbal IQ and vocabulary with the Kaufmann Assessment Battery for Children (KABC-II). Language skills were assessed in educator rating. The amount of children's screen exposure was negatively related to parental education and positively to distress. In the CG, higher amounts of screen time were associated with elevated cortisol levels and lower learning scores. On both measures, the RG and CG only differed in the condition of screen time less than one hour/day, for higher amounts of screen time the CG approached the more problematic scores of the RG. Whereas in the whole sample the amount of screen time was negatively correlated to language performance, it was not correlated to non-verbal IQ-scores. As a higher amount of media exposure in our clinical comparison group is associated with elevated biological stress, decreased learning and lower language performance, it should be classified as a relevant environmental factor and regularly considered in clinical assessments of children and therapeutical interventions, especially in vulnerable subgroups. German clinical trials register, registration number: DRKS00025734, date: 07-23-2021.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrolling through adolescence: a systematic review of the impact of TikTok on adolescent mental health. 滚动浏览青春期:TikTok 对青少年心理健康影响的系统回顾。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-16 DOI: 10.1007/s00787-024-02581-w
Giulia Conte, Giorgia Di Iorio, Dario Esposito, Sara Romano, Fabiola Panvino, Susanna Maggi, Benedetta Altomonte, Maria Pia Casini, Mauro Ferrara, Arianna Terrinoni
{"title":"Scrolling through adolescence: a systematic review of the impact of TikTok on adolescent mental health.","authors":"Giulia Conte, Giorgia Di Iorio, Dario Esposito, Sara Romano, Fabiola Panvino, Susanna Maggi, Benedetta Altomonte, Maria Pia Casini, Mauro Ferrara, Arianna Terrinoni","doi":"10.1007/s00787-024-02581-w","DOIUrl":"https://doi.org/10.1007/s00787-024-02581-w","url":null,"abstract":"<p><p>Amidst rising concerns about mental health in adolescents, the role of social media (SM), particularly highly visual platforms such as TikTok, has become a growing focus of investigation. In the extant literature, conclusive evidence is limited by the aggregate analysis of very heterogeneous SM platforms. This systematic scoping review examines the relationship between TikTok and mental health in adolescents. Additionally, it aims to highlight potential interactions between typical developmental processes and the unique aspects of TikTok, exploring their relevance to mental health within this demographic. Following PRISMA guidelines, a systematic search across PubMed, Scopus, Web of Knowledge, and PsychINFO yielded 20 studies that met the inclusion criteria, encompassing a total of 17,336 subjects from 10 countries. The retrieved studies analyzed four main topics related to TikTok use, i.e., the overall impact on adolescents' mental health, risk of problematic use and behavioral addiction, consequences on body image and self-esteem, and possible spreading of mental illness behaviors. While TikTok offers creative opportunities for self-expression and peer connection, the literature raises concerns about its potential negative effects on teens, such as lower life satisfaction, increased risk of \"contagion\" of certain psychiatric symptoms, and problematic usage patterns. Significant variations in study methodologies and outcome measures were observed. In the current era of evolving SM landscapes, a comprehensive approach informed by developmentally grounded research is critically needed to further understand the interplay between SM and adolescent mental health, providing insights for health authorities and policymakers.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Predictors of dropout, time spent on the program and client satisfaction in an internet-based, telephone-assisted CBT anxiety program among elementary school children in a population-based sample. 更正:基于互联网、电话辅助的小学生焦虑症 CBT 项目的辍学预测因素、项目花费的时间和客户满意度。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-12 DOI: 10.1007/s00787-024-02580-x
Katri Kaajalaakso, Terhi Luntamo, Tarja Korpilahti-Leino, Terja Ristkari, Susanna Hinkka-Yli-Salomäki, Andre Sourander
{"title":"Correction: Predictors of dropout, time spent on the program and client satisfaction in an internet-based, telephone-assisted CBT anxiety program among elementary school children in a population-based sample.","authors":"Katri Kaajalaakso, Terhi Luntamo, Tarja Korpilahti-Leino, Terja Ristkari, Susanna Hinkka-Yli-Salomäki, Andre Sourander","doi":"10.1007/s00787-024-02580-x","DOIUrl":"https://doi.org/10.1007/s00787-024-02580-x","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study. 阿戈美拉汀治疗中度至重度重度抑郁症儿科患者:一项开放标签延伸研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-10-10 DOI: 10.1007/s00787-024-02587-4
Celso Arango, Joerg M Fegert, Françoise Picarel-Blanchot, Ute Marx, Lucie Truffaut-Chalet, Pierre-François Pénélaud, Jan Buitelaar
{"title":"Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study.","authors":"Celso Arango, Joerg M Fegert, Françoise Picarel-Blanchot, Ute Marx, Lucie Truffaut-Chalet, Pierre-François Pénélaud, Jan Buitelaar","doi":"10.1007/s00787-024-02587-4","DOIUrl":"https://doi.org/10.1007/s00787-024-02587-4","url":null,"abstract":"<p><p>Major depressive disorder (MDD) in young people is a common psychiatric disorder, but treatment options are limited. Agomelatine has demonstrated short-term efficacy and safety in pediatric patients. We report here the results of a 92-week open-label extension (OLE). The international, multicenter, double-blind, study randomized 400 patients (80 children, 320 adolescents) with moderate-to-severe MDD to one of four treatment groups: agomelatine 10 mg (n = 102), agomelatine 25 mg (n = 95), placebo (n = 103), and fluoxetine 10-20 mg (n = 100). After 12 weeks, patients who could benefit from treatment continuation were offered entry into an optional OLE during which they received agomelatine 10 or 25 mg for a further 92 weeks. A total of 339 patients (271 adolescents) entered the OLE. Treatment groups considered for the OLE analysis reflected those received in the double-blind and OLE periods: agomelatine (10 or 25 mg) in both (ago/ago, n = 170); placebo then agomelatine 10-25 mg (pcb/ago, n = 85); or fluoxetine then agomelatine 10-25 mg (fluox/ago, n = 84). Mean age (± SD) at entry into the double-blind phase (Week 0) was 13.6 ± 2.7 years and 61.9% were female. Mean changes in Children's Depression Rating Scale revised (CDRS-R) raw total score from Week 12 to last post-Week 12 value in the three groups were - 16.3 ± 12.2 (ago/ago), - 18.9 ± 16.1 (pcb/ago), and - 16.1 ± 15.5 (fluox/ago), reflecting the difference in efficacy between treatments during the double-blind period, and heterogeneity at W12 between the treatment groups. Adverse events considered related to treatment occurred in 14.5% of patients: 15.3% ago/ago, 16.5% pcb/ago, and 10.7% fluox/ago. Three patients (all adolescents) experienced treatment-related severe adverse events: two treated with ago/ago and one treated with pcb/ago. Among the adolescents, one treatment-related severe adverse event in a patient in the pcb/ago group led to study withdrawal. Agomelatine was associated with continuous improvement in depressive symptoms without unexpected safety signals. These findings support the safe use of agomelatine in a pediatric population with moderate-to-severe MDD for up to 104 weeks.Trial registration No: EUDRACT No. 2015-002181-23.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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