与抽搐和精神病理共病相关的早期发育里程碑:EMTICS研究。

IF 4.9 2区 医学 Q1 PEDIATRICS
Tamar Steinberg, Dana Feldman-Sadeh, Alan Apter, Yael Bronstein, Noa Elfer, Miri Carmel, Elena Michaelovsky, Abraham Weizman, Matan Nahon, Danny Horesh, Astrid Morer, Blanca Garcia Delgar, Anette Schrag, Silvana Fennig, Pieter J Hoekstra, Andrea Dietrich, Noa Benaroya-Milshtein
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引用次数: 0

摘要

背景:包括抽动秽语综合征(TS)在内的慢性抽动障碍(CTD)与精神病理合并症有关。注意缺陷/多动障碍(ADHD)、自闭症谱系障碍(ASD)和其他合并症与早期发育里程碑的延迟有关。很少有研究调查了早期发育里程碑、抽动严重程度和相关合并症之间的关系。方法:383名来自欧洲多中心儿童抽动研究(EMTICS)基线评估的3-16岁CTD参与者(76.8%,n = 294名男孩),评估:回顾性早期发育里程碑(坐,行走,第一个单词,完成一个句子,膀胱和肠道控制),抽动严重程度,抽动相关功能障碍,强迫症(OCD), ADHD,对立违抗性障碍(ODD)和疑似ASD。使用金标准的自我报告和临床报告工具收集数据。分析包括Pearson相关性和逻辑回归。结果:发育里程碑的获得与抽动严重程度或抽动障碍之间的相关性显著,但效应大小较小(运动抽动和抽动障碍的严重程度与行走相关(r = 0.11),而声音抽动与第一个单词相关(r = 0.12))。Logistic回归分析显示,首词习得延迟与ADHD、ODD和疑似ASD显著相关(比值比分别为1-1.13、1.04-1.22、1.05-1.21),而行走习得延迟与强迫症显著相关(比值比分别为1.01-1.27)。讨论:本研究强调了CTD患者早期发育里程碑与后期精神病理合并症之间的关系。这些发现强调需要进一步的研究来区分只有抽搐的儿童和有抽搐和精神病理合并症的儿童,以提高对高危个体的早期发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early developmental milestones associated with tics and psychopathological comorbidity: An EMTICS study.

Background: Chronic Tic disorders (CTD) including Tourette Syndrome (TS), are associated with psychopathological comorbidities. Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and other comorbidities have been linked to delays in early developmental milestones. Few studies have investigated the relationship between early developmental milestones, tic severity, and related comorbidities.

Methods: 383 participants aged 3-16 years (76.8%, n = 294 boys) with CTD from the baseline assessment of the European Multicenter Tics in Children Study (EMTICS), were evaluated for: retrospective early developmental milestones (sitting, walking, first words, complete a sentence, bladder and bowel control), tic severity, tic-related functional impairment, obsessive-compulsive disorder (OCD), ADHD, oppositional defiant disorder (ODD) and suspected ASD. Data was collected using gold-standard self and clinician reporting instruments. Analyses included Pearson correlations and logistic regressions.

Results: Correlations between the acquisition of developmental milestones and tic severity or impairment were significant with small effect sizes (severity of motor tics and tic impairment were correlated with walking (r = .11), while vocal tics were correlated with first words (r = .12)). Logistic regression revealed that delayed acquisition of first words was significantly associated with ADHD, ODD and suspected ASD (Odds Ratio (ROR): 1-1.13, 1.04-1.22, 1.05-1.21, respectively), while delayed walking acquisition was associated with OCD (ROR: 1.01-1.27).

Discussion: This study highlights the association between early developmental milestones and later psychopathological comorbidities in CTD patients. These findings emphasize the need for further research to distinguish between children with only tics and those with tics and psychopathological comorbidities, to improve early detection of individuals at risk.

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来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
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