European Child & Adolescent Psychiatry最新文献

{"title":"Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome.","authors":"Zhongxin Huang, Helin Zheng, Longlun Wang, Shuang Ding, Rong Li, Yong Qing, Song Peng, Min Zhu, Jinhua Cai","doi":"10.1007/s00787-024-02631-3","DOIUrl":"https://doi.org/10.1007/s00787-024-02631-3","url":null,"abstract":"<p><p>Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by dysplasia in early life. Psychoradiology studies have suggested that mental and behavioral deficits in individuals with PWS are linked to abnormalities in brain structural and functional networks. However, little is known about changes in network-based structural-functional coupling and structural/functional topological properties and their correlations with developmental scales in children with PWS. Here, we acquired diffusion tensor imaging and resting-state functional magnetic resonance imaging data from 25 children with PWS and 28 age- and sex-matched healthy controls, constructed structural and functional networks, examined intergroup differences in structural-functional coupling and structural/functional topological properties (both global and nodal), and tested their partial correlations with developmental scales. We found that children with PWS exhibited (1) decreased structural-functional coupling, (2) a higher characteristic path length and lower global efficiency in the structural network in terms of global properties, (3) alterations in classical cortical and subcortical networks in terms of nodal properties, with the structural network dominated by decreases and the functional network dominated by increases, and (4) partial correlation with developmental scales, especially for functional networks. These findings suggest that structural-functional decoupling and abundant structural/functional network topological properties may reveal the mechanism of early neurodevelopmental delays in PWS from a neuroimaging perspective and might serve as potential markers to assess early neurodevelopmental backwardness in PWS.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of types of on-screen content with mental health problems among Chinese adolescents.","authors":"Chengcheng Zhang, Weijing Peng, Zhiyan Chen, Cong Lai, Shuiyuan Xiao, Mi Hu","doi":"10.1007/s00787-024-02632-2","DOIUrl":"https://doi.org/10.1007/s00787-024-02632-2","url":null,"abstract":"<p><p>Excessive screen time was associated with mental health problems, yet whether the associations differ by screen content types remain unknown. Here, we conducted a cross-sectional study of adolescents from 156 junior and high school to investigate the association of types of on-screen content with mental health problems in China. The exposure variable was screen exposure, measured by the self-reported questionnaire. Symptoms of depression and anxiety were assessed by Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale-7 (GAD-7), respectively. Suicide-related behavior was adapted from the Centers for Disease Control's Youth Risk Behavior Surveillance. Generalized linear models and network analysis were performed. Of the 15,194 adolescents included in the final analysis, 8,019 were males and mean (SD) age was 14.50 (1.68) years. 34.6% of adolescents had an average screen time of ≥ 4 h/day on weekends. The most frequently used screen contents (≥ 4 h/d) were electronic games (9.1%), followed by short video (6.6%). Learning online had strong associations with depression (OR = 2.03, 95%CI: 1.29-3.11, P = 0.002) and anxiety (OR = 2.05, 95%CI: 1.24-3.27, P = 0.004) symptoms. The associations between on-screen content and mental health varied. The strongest edges linked to screen content types were edge between \"Electronic games\" and \"Anhedonia\" in the network model. \"Control worry\" was the most central nodes, followed by \"Irritable\" and \"Worry A Lot\". Findings suggested that both screen time and different types of screen content were associated with mental health problems among adolescents. Limiting screen exposure and developing effective interventions to improve mental health should be a priority.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating youth mental health practice nurses into general practice: effects on outpatient mental health care utilization among children and adolescents.","authors":"Lukas B M Koet, Sanne Verhoog, Özcan Erdem, Heike Gerger, Patrick J E Bindels, Evelien I T de Schepper, Wilma Jansen","doi":"10.1007/s00787-024-02619-z","DOIUrl":"https://doi.org/10.1007/s00787-024-02619-z","url":null,"abstract":"<p><p>Integration of child mental health services in general practice may improve early detection and treatment and reduce strain on specialized services. In this study we investigated whether outpatient mental health care utilization and associated costs in children and adolescents were affected by the introduction of youth mental health practice nurses (YMHPNs) in general practice. We linked healthcare data of the Rijnmond Primary Care Database to municipal registry data on child outpatient mental health care expenditures between 2019 and 2022. Using mixed models, we assessed if the presence of a YMHPN in practices was associated with outpatient mental health care utilization. Our cohort consisted of 33,971 children aged 0-17 years registered in 38 general practices in Rotterdam, the Netherlands. 5.5% of these children attended outpatient mental health services between 2019 and 2022. The proportion of children utilizing outpatient mental health care and associated costs increased over time. After correction for practice demographics and trends over time, the presence of a YMHPN in a practice was associated with small non-significant reductions in the number of children receiving outpatient care (Rate Ratio = 0.99, 95%CI 0.92 to 1.06) and associated costs (-395.80 euros 95%CI -1431.27 to 639.67) compared with practices without YMHPN. Considering the study limitations, we cautiously concluded that the introduction of YMHPNs in general practice was not associated with significant changes in outpatient mental health care utilization one to four years after implementation. Future studies should elucidate the long-term impact and underlying changes in pathways to care due to the introduction of the YMHPN.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond nature & nurture.","authors":"Jörg M Fegert","doi":"10.1007/s00787-024-02614-4","DOIUrl":"https://doi.org/10.1007/s00787-024-02614-4","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Correlation of screen exposure to stress, learning, cognitive and language performance in children.","authors":"Andrea Hahnefeld, Monika Fink, Saskia Le Beherec, Marie Anna Baur, Katharina Bernhardt, Volker Mall","doi":"10.1007/s00787-024-02625-1","DOIUrl":"https://doi.org/10.1007/s00787-024-02625-1","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective targets of intervention on generalized anxiety symptoms across whole adolescence and emerging adulthood: network analysis and insilico intervention.","authors":"Feng Li, Yihong Zhang, Yuan Fang, Zhiyan Chen","doi":"10.1007/s00787-024-02626-0","DOIUrl":"https://doi.org/10.1007/s00787-024-02626-0","url":null,"abstract":"<p><p>Early-onset generalized anxiety symptoms have severe impacts on youth development. Age differences in anxiety symptoms are obscure. Effective intervention targets need further investigation. Adolescents and emerging adults (N = 65,048; 10-24 years; 50.63% female; M_age = 15.78, SD = 3.62) reported generalized anxiety symptoms and demographic information. They were divided into four subgroups: early adolescence (10-12 years), middle adolescence (13-15 years), late adolescence (16-18 years), and emerging adulthood (19-24 years) according to their developmental stages. Network analysis was used to compare age differences in symptom roles between subgroups. In silico intervention (i.e., computer simulation-based intervention) was employed to disclose the intervention targets (i.e., treatment and prevention targets) and efficacy of symptom-specific interventions within dynamic network systems. Network comparison tests indicated that the involvement of anxiety symptoms in networks varied with developmental stages, particularly between early and middle adolescence. In silico intervention revealed that nervousness was the most effective treatment target to alleviate network state in all subgroups. Excessive worry in early adolescence and uncontrollable worry from middle adolescence to emerging adulthood emerged as the most effective prevention targets. The current study highlights the importance of middle adolescence as a crucial phase for preventive intervention and emphasizes the need for differentiated prevention and treatment strategies for particular populations.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling developmental trajectories of childhood anxiety and depression symptoms in the prediction of adolescent substance use.","authors":"Kelsey L M Bowie, Émilie Fletcher, Michèle Déry, Annie Lemieux, Caroline E Temcheff","doi":"10.1007/s00787-024-02624-2","DOIUrl":"https://doi.org/10.1007/s00787-024-02624-2","url":null,"abstract":"<p><p>Adolescent substance use is comorbid with internalizing problems (e.g., anxious and depressive symptoms) and externalizing problems (EPs). Developmental researchers have linked early anxious and depressive symptoms to later substance use behaviours via an \"internalizing pathway\". Support for this pathway exists among young adults; however, evidence from prospective studies of adolescents has been inconsistent. Given the paucity of prospective studies in this area, the current study used a developmental framework to examine childhood anxiety and depression symptom trajectories as predictors of adolescent substance use and whether these relationships depend on sex and EPs. Children with and without EPs participated annually in an ongoing longitudinal study (N = 744; Time 1 age = 6.3-10.6). Youth completed self-report measures of anxiety and depression symptoms (Times 3-6) and substance use (Times 7-8). Parents and teachers completed measures of children's EPs (Time 0). Parallel process growth models showed that changes over time in childhood depression symptoms were significantly positively associated with adolescent alcohol/cannabis use, substance-related consequences, and total score of problematic substance use. Changes over time in childhood anxiety symptoms were significantly negatively associated with adolescent alcohol/cannabis use. These results were invariant by EPs and sex. Research implications of this study emphasize the importance of isolating the respective pathways of anxious and depressive symptoms to later substance use outcomes, while clinical implications focus on targets for early identification and prevention of problematic substance use in adolescence.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social factors behind the AFAB predominance in LGBT youths: evidence from a large European survey.","authors":"Claire Vandendriessche, David Cohen","doi":"10.1007/s00787-024-02595-4","DOIUrl":"https://doi.org/10.1007/s00787-024-02595-4","url":null,"abstract":"<p><p>Trans youth reports reveal a predominance of assigned female at birth (AFAB) people (i.e. transmasculine people) over assigned male at birth (AMAB) people (i.e. transfeminine people). It has been suggested that \"social contagion\" through social media could be more frequent in AFAB people, causing a hypothesized \"rapid-onset gender dysphoria\" (ROGD) in adolescence, with detrimental correlates to health. We aim to test (1) whether the suggested effect of ROGD on an AFAB predominance in adolescence could have an alternative explanation such as the effect of national LGBT policies; (2) the suggested effects of ROGD by which transmasculine people who had a more rapid development of their trans identity in adolescence would use more often social media to connect to peers and would have a lower health status. Regarding our methods, we used the cross-sectional LGTI Survey II (2019) of the European Union Agency for Fundamental Rights (137,553 LGBT people) and the ILGA-Europe's Rainbow Index (2019) of national LGBT policy scores. We calculated the chances to recognize and share an LGBT identity for AFAB/AMAB cis/trans people, expected sex ratios for cis/trans people at every age given equal total AFAB and AMAB populations, and national AFAB vs. AMAB differences in ages of LGBT identity-sharing adjusted by their ages of self-perception. We tested among adolescent respondents whether belonging to the hypothesized ROGD population was associated with social media use or poorer self-assessed health. As regards our findings, we predicted a predominance of AFAB trans adolescents as well as AFAB LGB cis adolescents in accordance with our observation that AMAB youth shared their identity later than AFAB youth in all 30 countries, their age of self-perception being held equal. We found that national differences in ages of identity-sharing significantly correlated with ILGA-Europe's Rainbow Index. We did not find that transmasculine people who had a rapid development of a trans identity in adolescence used more social media or had worse health. However, when we restricted the sample to those who were adolescents in the survey (N = 6209), we found that transmasculine youth who had a more rapid affirmation (< 1 year) used more frequently social media, though they did not have poorer health. To conclude, the AFAB predominance in adolescence may not be trans-specific. The effect of social influence on the emergence of LGBT identities in adolescence may exist at the micro level (social media use by transmasculine adolescents) but also at the macro level (state laws). These findings give support to some of the ROGD hypothesis features but contradict others, and plead for more research on how gender minority stress affects the likelihood of LGBT people to disclose their identity.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design.","authors":"Igor Duarte, Mauricio Scopel Hoffmann, Giovanni A Salum, Douglas Teixeira Leffa, Sintia Belangero, Marcos Santoro, Vanessa Kiyomi Ota, Lucas Toshio Ito, Pedro M Pan, Luis C Farhat, Aja Louise Murray, Euripedes C Miguel, Christian Kieling, Luis Augusto Rohde, Arthur Caye","doi":"10.1007/s00787-024-02622-4","DOIUrl":"https://doi.org/10.1007/s00787-024-02622-4","url":null,"abstract":"<p><p>Translation of biomarkers to clinical practice is hindered by the significant overlap in neurobiological measures between ADHD cases and controls. A risk-informed design can enhance the utility and validation of ADHD biomarkers by highlighting differences between individuals with ADHD and those without at differential risk. Participants were 2511 children and adolescents (aged 6 to 14 years) from the Brazilian High Risk Cohort for Mental Conditions. We calculated risk for ADHD among unaffected individuals using a multivariable clinical and sociodemographic risk model. We compared measures of three proposed ADHD biomarkers (polygenic scores, subcortical volumes, and executive function) between participants with vs. without ADHD, and ADHD vs. without ADHD with a high- vs. low-risk loading for ADHD. Compared to the unaffected group, children and adolescents with ADHD had higher ADHD polygenic scores (cohen's d = 0.17), smaller subcortical volumes (d = - 0.25), and poorer executive function (d = - 0.22). Separating the unaffected group into low- and high-risk subgroups revealed more pronounced differences (Cohen's d = 0.20 to 0.60) and nearly doubled the overlap-free area for these three neurobiological measures between the low-risk group and the other two groups. Upon adjustment for the number of ADHD symptoms, simple ADHD vs. without ADHD differences vanished, while the risk-informed analyses remained significant. Here, we demonstrate that a risk-based design increases effect sizes when comparing candidate biomarkers for ADHD. Our study provides a model that may hold promise for evaluating similar contrasts in other mental disorders and samples.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data.","authors":"Carlos De Las Cuevas, Emilio J Sanz, Sara Jiménez-Fernández, Georgios Schoretsanitis, Can-Jun Ruan, Jose de Leon","doi":"10.1007/s00787-024-02623-3","DOIUrl":"https://doi.org/10.1007/s00787-024-02623-3","url":null,"abstract":"<p><p>Pharmacovigilance findings have marked clozapine use. Prescribers and package inserts worldwide focus on clozapine-induced neutropenia. The literature on clozapine adverse drug reactions (ADRs) for those under age 18 and their associated fatal outcomes is limited. Reports to the World Health Organization's global pharmacovigilance database (VigiBase) were analyzed among patients under 18 years of age extending from clozapine's introduction to June 1, 2022. There were 2825 reports of clozapine, including 42 fatal outcomes (relative lethality = 1.5% vs. 11.7% in all ages). After 280 cases were excluded (clozapine exposure during pregnancy, accidental exposure or unclear age), 2455 were included with ADRs during therapeutic use. Decreased white blood cell (WBC) count provided the most frequent aggregated ADR, accounting for 934 cases (37% of 2545), with only 1 fatal outcome (0.01%, 1/934). Suicide explained 7 of 27 (26%) non-duplicated fatal outcomes. Next in importance was clozapine-induced gastrointestinal hypomotility (CIGH) with 3 cases (11% of 27) and neuroleptic malignant syndrome with 2 cases (7% of 27). Agranulocytosis, aspiration, myocarditis, myocardiopathy and ventricular arrythmia led to single fatal cases. Based on these new findings and recent literature in all ages, to prevent fatal outcomes, child and adolescent psychiatrists need to shift their focus from severe neutropenia to other ADRs including pneumonia, respiratory aspiration and CIGH. In spite of its potential toxicity during overdoses, clozapine may have specific and strong anti-suicidal effects when compared with other antipsychotics. Child and adolescent psychiatrists need to take extreme precautions to avoid intentional overdoses when prescribing clozapine to patients with suicide risk.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}