围产期抑郁症母亲的后代的焦虑和抑郁障碍。

IF 4.9 2区 医学 Q1 PEDIATRICS
Biruk Shalmeno Tusa, Rosa Alati, Getinet Ayano, Kim Betts, Berihun Dachew
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引用次数: 0

摘要

母亲围产期抑郁与后代焦虑和抑郁的风险增加有关。然而,许多研究受到样本量小、自我报告数据和对混杂因素(包括共病性产妇焦虑症)调整不足的限制。本研究使用来自澳大利亚新南威尔士州的大型关联行政健康数据集,旨在检查围产期抑郁症母亲的后代患焦虑和抑郁症的风险,并使用国际疾病分类第十版澳大利亚修订(icd - 10am)代码确定诊断。使用广义线性模型和倾向评分匹配评估关联。患有围产期抑郁症的母亲的后代患抑郁症的风险高出56% (RR = 1.56, 95% CI = 1.05-2.29),尽管在匹配后没有观察到这一点(RR = 1.42, 95% CI = 0.93-2.18)。孕妇围产期抑郁障碍与焦虑障碍的高风险相关(RR = 2.10, 95% CI = 1.78-2.48),在倾向评分匹配后仍具有显著性(RR = 1.90, 95% CI = 1.59-2.28)。患有围产期抑郁和焦虑共病的母亲的后代患抑郁症的风险高出2.36倍(RR = 2.36, 95% CI = 1.21-4.63),患焦虑症的风险高出2.56倍(RR = 2.56, 95% CI = 1.89-3.48),患抑郁和焦虑共病的风险高出3.37倍(RR = 3.37, 95% CI = 1.54-7.36)。这些发现强调了患有围产期抑郁症的母亲的后代患抑郁症和焦虑症的风险增加,当母亲抑郁与焦虑共存时,观察到的相关性更强。结果强调需要早期发现和有针对性的干预孕产妇围产期抑郁和焦虑障碍,以减少后代的不良心理健康结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anxiety and depressive disorders in the offspring of mothers with perinatal depressive disorders.

Maternal perinatal depression has been linked to increased risk of anxiety and depression in offspring. However, many studies are limited by small sample sizes, self-reported data, and insufficient adjustment for confounders, including comorbid maternal anxiety disorders. Using a large linked administrative health dataset from New South Wales, Australia, this study aimed to examine the risk of anxiety and depressive disorders among offspring of mothers with perinatal depressive disorders, with diagnoses identified using the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10 AM) codes. Associations were assessed using generalized linear model and propensity score matching. Offspring of mothers with perinatal depressive disorders had a 56% higher risk of depressive disorders (RR = 1.56, 95% CI = 1.05-2.29), though this was not observed after matching (RR = 1.42, 95% CI = 0.93-2.18). Maternal perinatal depressive disorders were associated with a higher risk of anxiety disorders (RR = 2.10, 95% CI = 1.78-2.48), which remained significant after propensity score matching (RR = 1.90, 95% CI = 1.59-2.28). Offspring of mothers with comorbid perinatal depressive and anxiety disorders had a 2.36-fold higher risk of depressive disorders (RR = 2.36, 95% CI = 1.21-4.63), a 2.56-fold higher risk of anxiety disorders (RR = 2.56, 95% CI = 1.89-3.48), and a 3.37-fold higher risk of comorbid depressive and anxiety disorders (RR = 3.37, 95% CI = 1.54-7.36). These findings highlight the increased risk of depressive and anxiety disorders in offspring of mothers with perinatal depressive disorders, with stronger associations observed when maternal depression coexists with anxiety. The results underscore the need for early detection and targeted interventions for maternal perinatal depressive and anxiety disorders to reduce adverse mental health outcomes in offspring.

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来源期刊
CiteScore
12.80
自引率
4.70%
发文量
186
审稿时长
6-12 weeks
期刊介绍: European Child and Adolescent Psychiatry is Europe''s only peer-reviewed journal entirely devoted to child and adolescent psychiatry. It aims to further a broad understanding of psychopathology in children and adolescents. Empirical research is its foundation, and clinical relevance is its hallmark. European Child and Adolescent Psychiatry welcomes in particular papers covering neuropsychiatry, cognitive neuroscience, genetics, neuroimaging, pharmacology, and related fields of interest. Contributions are encouraged from all around the world.
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