European Child & Adolescent Psychiatry最新文献

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Negative family and interpersonal relationship are associated with centromedial amygdala functional connectivity alterations in adolescent depression. 消极的家庭和人际关系与青少年抑郁症患者杏仁核中央区功能连接的改变有关。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI: 10.1007/s00787-024-02456-0
Weijie Bao, Yingxue Gao, Ruohan Feng, Lingxiao Cao, Zilin Zhou, Lihua Zhuo, Hongwei Li, Xinqin Ouyang, Xinyue Hu, Hailong Li, Guoping Huang, Xiaoqi Huang
{"title":"Negative family and interpersonal relationship are associated with centromedial amygdala functional connectivity alterations in adolescent depression.","authors":"Weijie Bao, Yingxue Gao, Ruohan Feng, Lingxiao Cao, Zilin Zhou, Lihua Zhuo, Hongwei Li, Xinqin Ouyang, Xinyue Hu, Hailong Li, Guoping Huang, Xiaoqi Huang","doi":"10.1007/s00787-024-02456-0","DOIUrl":"10.1007/s00787-024-02456-0","url":null,"abstract":"<p><p>The amygdala, known for its functional heterogeneity, plays a critical role in the neural mechanism of adolescent major depressive disorder (aMDD). However, changes in its subregional functional networks in relation to stressful factors remain unclear. We recruited 78 comorbidity-free, medication-naive aMDD patients and 40 matched healthy controls (HC) to explore changes in resting-state functional connectivity (FC) across four amygdala subregions: the centromedial nucleus (CM), the basolateral nucleus (LB), the superficial nucleus (SF), and the amygdalostriatal transition area (Astr). Then, we performed partial correlation analysis to investigate the relationship between amygdala subregional FC and stressful factors as measured by the Chinese Version of Family Environment Scale (FES-CV) and the Adolescent Self-Rated Life Events Scale (ASLEC). Compared to HC, aMDD patients demonstrated significantly decreased functional connectivity between the left CM and left precentral gyrus, as well as between left SF and left precentral gyrus, and between left LB and posterior cingulate gyrus (PCC)/precuneus. In aMDD group, left CM-precentral gyrus FC exhibited negative correlation with interpersonal relationship and punishment, and positive correlation with family cohesion and expressiveness. This study reveals distinct patterns of abnormal functional connectivity among amygdala subregions in aMDD. Our findings suggest that the CM network, in particular, may be involved in stress-related factors in aMDD, which provide a potential target for the prevention and treatment of adolescent depression.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4195-4204"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative study of the lived experience of methylphenidate prescribed for children with a fetal alcohol spectrum disorder. 关于为患有胎儿酒精谱系障碍的儿童开具哌醋甲酯处方的生活体验的定性研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-16 DOI: 10.1007/s00787-024-02457-z
Clémentine Morin, Bérénice Doray, Cécilia Dumar, Jude Balit, Nicolas Bouscaren, Michel Spodenkiewicz
{"title":"Qualitative study of the lived experience of methylphenidate prescribed for children with a fetal alcohol spectrum disorder.","authors":"Clémentine Morin, Bérénice Doray, Cécilia Dumar, Jude Balit, Nicolas Bouscaren, Michel Spodenkiewicz","doi":"10.1007/s00787-024-02457-z","DOIUrl":"10.1007/s00787-024-02457-z","url":null,"abstract":"<p><p>Fetal Alcohol Spectrum Disorders (FASD) refer to physical, cognitive, and behavioural symptoms in an individual whose mother consumed alcohol during pregnancy. It is the leading cause of non-genetic avoidable mental disability, with an estimated worldwide prevalence of 1%. Attention Deficit Hyperactivity Disorder (ADHD) diagnostic criteria are met for 50-80% of patients with FASD. Methylphenidate (MPH) is the first-line pharmacological treatment for ADHD. This study aims to explore the lived experience of children with FASD taking MPH and their caregivers to adapt prescribing modalities by considering different ways to administer the drugs. We hope to improve the therapeutic alliance between the children and their caregivers by gaining an insiders' view of the medication perception. Semi-structured interviews with children and their caregivers were conducted in this qualitative study. Data collection by purposive sampling continued until we reached theoretical sufficiency. Data were analysed using interpretative phenomenological analysis. We conducted 16 semi-structured interviews: 8 with the children aged 7-12, 5 boys and 3 girls and 8 with their caregivers. The analysis showed that inadequate palatability and capsule form experiences were the leading causes of children's non-adherence to the treatment. MPH appeared to be a valuable aid for caregivers even if they had concerns about its potential toxicity. However, it is necessary to identify caregivers' expectations concerning MPH to adapt the prescription in terms of choice of specialty and intake modalities. Regular support was required to reduce caregivers' fears of dependence, personality transformation and long-term adverse effects. Information on palatability should be given when prescribing MPH to children with ADHD as well as its possible side effects or toxicity. It highlights the need for further studies of the experience of palatability of drugs prescribed to children. When prescribing a treatment, children should be more involved in medical counselling and it is necessary to understand the child's perspectives to co-construct common representations for better therapeutical adherence.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4219-4235"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A closer look into the affect dynamics of adolescents with depression and the interactions with their parents: An ecological momentary assessment study. 青少年抑郁症患者的情感动态及其与父母的互动:生态瞬间评估研究
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-18 DOI: 10.1007/s00787-024-02447-1
Loes H C Janssen, Bart Verkuil, Lisanne A E M van Houtum, Mirjam C M Wever, Wilma G M Wentholt, Bernet M Elzinga
{"title":"A closer look into the affect dynamics of adolescents with depression and the interactions with their parents: An ecological momentary assessment study.","authors":"Loes H C Janssen, Bart Verkuil, Lisanne A E M van Houtum, Mirjam C M Wever, Wilma G M Wentholt, Bernet M Elzinga","doi":"10.1007/s00787-024-02447-1","DOIUrl":"10.1007/s00787-024-02447-1","url":null,"abstract":"<p><p>Adolescents with depression tend to perceive behavior of parents as less positive than adolescents without depression, but conclusions are based on retrospective reports assessed once or over long time intervals, with the risk of memory biases affecting the recall. The current study used ecological momentary assessments to examine the link between adolescent affect and the amount of warmth and criticism expressed by both mothers and fathers in families with adolescents with depression versus adolescents without psychopathology in daily life. It also explored the possible bias by assessing parenting on the momentary, daily (EMA), and retrospective level. The sample consisted of 34 adolescents with depression and 58 parents and 80 healthy controls and 151 parents (adolescents: M<sub>age</sub> = 15.8, SD = 1.41; 67.5% girls, parents: M<sub>age</sub> = 49.3, SD = 5.73; 54.1% mothers). Participants completed retrospective questionnaires and four surveys a day for 14 consecutive days. Preregistered multilevel models showed that momentary parenting reports of adolescents with depression and healthy controls did not differ. The associations between perceived parenting of both mothers and fathers and adolescent affect did also not differ between the two groups. These results illustrate that adolescents generally benefit from supportive parenting, but substantial differences between individuals were found. In contrast to the momentary data, both adolescents with depression and their parents did report more negative parenting on retrospective questionnaires than healthy controls and their parents indicating that adolescents with depression may have a negativity bias in their retrospective recall. These findings are highly relevant for clinical practice and underscore the need for careful assessments on different time scales and including all family members.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4259-4272"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-year follow-up of the iBerry Study: screening in early adolescence to identify those at risk of psychopathology in emerging adulthood. iBerry 研究的五年跟踪:在青春期早期进行筛查,以确定在成年后有精神病理学风险的人群。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI: 10.1007/s00787-024-02462-2
D C Bouter, S J Ravensbergen, N G M de Neve-Enthoven, M Zarchev, C L Mulder, W J G Hoogendijk, S J Roza, N H Grootendorst-van Mil
{"title":"Five-year follow-up of the iBerry Study: screening in early adolescence to identify those at risk of psychopathology in emerging adulthood.","authors":"D C Bouter, S J Ravensbergen, N G M de Neve-Enthoven, M Zarchev, C L Mulder, W J G Hoogendijk, S J Roza, N H Grootendorst-van Mil","doi":"10.1007/s00787-024-02462-2","DOIUrl":"10.1007/s00787-024-02462-2","url":null,"abstract":"<p><p>The iBerry Study, a Dutch population-based high-risk cohort (n = 1022) examines the transition from subclinical symptoms to psychiatric disorders in adolescents. Here, we present the first follow-up measurement, approximately 3 years after baseline assessment and 5 years after the screening based on self-reported emotional and behavioral problems (SDQ-Y). We give an update on the data collection, details on the (non)response, and the results on psychopathology outcomes. The first follow-up (2019-2022) had a response rate of 79% (n = 807). Our results at baseline (mean age 15.0 years) have shown the effectiveness of using the SDQ-Y to select a cohort oversampled for the risk of psychopathology. At first follow-up (mean age 18.1 years), the previously administered SDQ-Y remains predictive for selecting adolescents at risk. At follow-up, 47% of the high-risk adolescents showed significant mental health problems based on self- and parent reports and 46% of the high-risk adolescents met the criteria for multiple DSM-5 diagnoses. Compared to low-risk adolescents, high-risk adolescents had a sevenfold higher odds of significant emotional and behavioral problems at follow-up. Comprehensive assessment on psychopathology, substance abuse, psychotic symptoms, suicidality, nonsuicidal self-injury, addiction to social media and/or video gaming, and delinquency, as well as social development, and the utilization of healthcare and social services were conducted. This wave, as well as the ones to follow, track these adolescents into their young adulthood to identify risk factors, elucidate causal mechanisms, and discern pathways leading to both common and severe mental disorders. Results from the iBerry Study will provide leads for preventive interventions.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4285-4294"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study. 合并精神分裂症和强迫症患者的父母精神障碍:一项全国范围的家庭联系研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1007/s00787-024-02480-0
Tien-Wei Hsu, Shih-Jen Tsai, Ya-Mei Bai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
{"title":"Parental mental disorders in patients with comorbid schizophrenia and obsessive-compulsive disorder: a nationwide family-link study.","authors":"Tien-Wei Hsu, Shih-Jen Tsai, Ya-Mei Bai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen","doi":"10.1007/s00787-024-02480-0","DOIUrl":"10.1007/s00787-024-02480-0","url":null,"abstract":"<p><p>Schizophrenia is highly comorbid with obsessive-compulsive disorder (OCD); both conditions share numerous pathophysiological etiologies. We, thus, examined the risk of mental disorders in the parents of probands with schizophrenia, OCD, or both conditions. Between 2001 and 2011, we enrolled a nationwide cohort of 69,813 patients with schizophrenia, OCD, or both. The control cohort included 698,130 individuals matched for demographics. Poisson regression models were employed to examine the risk of six mental disorders in their parents, including schizophrenia, bipolar disorder, depressive disorder, OCD, alcohol use disorder, and substance use disorder. We stratified patients into schizophrenia-only, OCD-only, and dual-diagnosis groups, and the dual-diagnosis group was further divided into schizophrenia-first, OCD-first, and simultaneously diagnosed groups. Compared with controls, the schizophrenia, OCD, and dual-diagnosis groups had higher risks for the six mental disorders in their parents (range of odds ratio [OR] 1.50-7.83). The sub-analysis of the dual-diagnosis group showed that the schizophrenia-first, OCD-first, and simultaneously diagnosed groups had higher odds for schizophrenia, bipolar disorder, depressive disorder, and OCD (range of OR 1.64-6.45) in their parents than the control group; the simultaneously diagnosed and OCD-first diagnosed groups had a higher odds of parental substance use disorder, while the schizophrenia-first diagnosed group had a higher odds of parental alcohol use disorder. The interrelationship between OCD and schizophrenia is linked to bipolar disorder, depressive disorder, alcohol use disorder, and substance use disorder. The results have implications for mental health policy and future research.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4325-4334"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexually transmitted infection and teenage pregnancy in adolescents having parents with schizophrenia: a retrospective cohort study of 64,350 participants. 父母患有精神分裂症的青少年的性传播感染与少女怀孕:一项对 64,350 名参与者进行的回顾性队列研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-24 DOI: 10.1007/s00787-024-02470-2
Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
{"title":"Sexually transmitted infection and teenage pregnancy in adolescents having parents with schizophrenia: a retrospective cohort study of 64,350 participants.","authors":"Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen","doi":"10.1007/s00787-024-02470-2","DOIUrl":"10.1007/s00787-024-02470-2","url":null,"abstract":"<p><strong>Background: </strong>The risks of sexually transmitted infections (STIs) and teenage pregnancy in the offspring of parents with schizophrenia remain unknown.</p><p><strong>Methods: </strong>From the Taiwan National Health Insurance Research Database, 5,850 individuals born between 1980 and 1999 having any parent with schizophrenia and 58,500 age-, sex-, income- and residence-matched controls without parents with severe mental disorders were enrolled in 1996 or on their birthdate and followed up to the end of 2011. Those who contracted any STI or became pregnant in adolescence during the follow-up period were identified.</p><p><strong>Results: </strong>Cox regression analyses demonstrated that offspring of parents with schizophrenia (hazard ratio [HR]: 1.21, 95% confidence interval [CI]: 1.02-1.44), especially daughters (HR: 1.30, 95% CI: 1.06-1.58), were more likely to contract any STI later in life than the control comparisons. In addition, daughters of parents with schizophrenia had an elevated risk of being pregnant in their adolescence (HR: 1.47, 95% CI: 1.29-1.67) compared with those having no parents with severe mental disorders.</p><p><strong>Discussion: </strong>The positive relationship between parental schizophrenia and offspring STIs and teenage pregnancy necessitates clinicians and public health officers to closely monitor the sexual health in the offspring of parents with schizophrenia so that optimal and prompt preventive measures can be taken in the at-risk group.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4295-4302"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood. 跨越发展期的情绪问题:研究童年、青春期和成年早期的测量不一致性。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-05-16 DOI: 10.1007/s00787-024-02461-3
Lucy Riglin, Charlotte Dennison, Joanna Martin, Foteini Tseliou, Jessica M Armitage, Amy Shakeshaft, Jon Heron, Kate Tilling, Anita Thapar, Stephan Collishaw
{"title":"Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood.","authors":"Lucy Riglin, Charlotte Dennison, Joanna Martin, Foteini Tseliou, Jessica M Armitage, Amy Shakeshaft, Jon Heron, Kate Tilling, Anita Thapar, Stephan Collishaw","doi":"10.1007/s00787-024-02461-3","DOIUrl":"10.1007/s00787-024-02461-3","url":null,"abstract":"<p><p>Emotional problems (anxiety, depression) are prevalent in children, adolescents and young adults with varying ages at onset. Studying developmental changes in emotional problems requires repeated assessments using the same or equivalent measures. The parent-rated Strengths and Difficulties Questionnaire is commonly used to assess emotional problems in childhood and adolescence, but there is limited research about whether it captures a similar construct across these developmental periods. Our study addressed this by investigating measurement invariance in the scales' emotional problems subscale (SDQ-EP) across childhood, adolescence and early adulthood. Data from two UK population cohorts were utilised: the Millennium Cohort Study (ages 3-17 years) and the Avon Longitudinal Study of Parents and Children (4-25 years). In both samples we observed weak (metric) measurement invariance by age, suggesting that the parent-rated SDQ-EP items contribute to the underlying construct of emotional problems similarly across age. This supports the validity of using the subscale to rank participants on their levels of emotional problems in childhood, adolescence and early adulthood. However strong (scalar) measurement invariance was not observed, suggesting that the same score may correspond to different levels of emotional problems across developmental periods. Comparisons of mean parent-rated SDQ-EP scores across age may therefore not be valid.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4237-4245"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of the psychometric properties of tools for measuring depression in youths with intellectual disability. 对智障青少年抑郁测量工具的心理测量特性进行系统回顾。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-03-20 DOI: 10.1007/s00787-024-02405-x
Xavier Benarous, Sandy Walesa, Jean-Marc Guilé, Cora Cravero, Angèle Consoli, David Cohen, Héloïse Young, Real Labelle, Hélène Lahaye
{"title":"A systematic review of the psychometric properties of tools for measuring depression in youths with intellectual disability.","authors":"Xavier Benarous, Sandy Walesa, Jean-Marc Guilé, Cora Cravero, Angèle Consoli, David Cohen, Héloïse Young, Real Labelle, Hélène Lahaye","doi":"10.1007/s00787-024-02405-x","DOIUrl":"10.1007/s00787-024-02405-x","url":null,"abstract":"<p><p>While youths with intellectual disability (ID) have increased vulnerability for depressive disorders, cognitive problems and combined functional barriers make them less prone to receive adequate treatments. A systematic review of the literature was conducted (PROSPERO Registration number: CRD42022347703) based on several databases from 1980 to 2022 to examine the quality of tools for measuring depression in children and adolescents with ID. The COSMIN (COnsensus-based Standards for the selection of health status Measurement Instruments) checklist was used to assess several psychometric domains. Twelve studies evaluated the properties of six tools for measuring depression in youths with ID. The Center for Epidemiologic Studies Depression Scale-Intellectual Disability (CESD-ID) was the only scale with at least five domains of psychometric properties assessed to have strong or moderate evidence. Based on the reviewed findings, tools specifically developed for populations with developmental disabilities should be considered first in order to screen depression in youths with ID. Much work is required to confirm their validity in clinical samples with patients with a complex form of developmental disabilities. As a complement to self- and caregivers-report questionnaires, clinician rating scales were considered useful to catch the full picture of depression in youths with ID, in particular associated behavioral expressions. Their validity received little scrutiny and certainly deserve more attention to improve care practice of youths with ID.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4061-4082"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor. 致编辑的信
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 DOI: 10.1007/s00787-024-02435-5
Ben Milbourn
{"title":"Letter to the Editor.","authors":"Ben Milbourn","doi":"10.1007/s00787-024-02435-5","DOIUrl":"10.1007/s00787-024-02435-5","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4405-4406"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up. 22q11.2 缺失综合征患者转为精神障碍的临床过程:长期回顾性随访。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1007/s00787-024-02469-9
Katerina Kulikova, Maude Schneider, Donna M McDonald McGinn, Shira Dar, Michal Taler, Maya Schwartz-Lifshitz, Stephan Eliez, Raquel E Gur, Doron Gothelf
{"title":"The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up.","authors":"Katerina Kulikova, Maude Schneider, Donna M McDonald McGinn, Shira Dar, Michal Taler, Maya Schwartz-Lifshitz, Stephan Eliez, Raquel E Gur, Doron Gothelf","doi":"10.1007/s00787-024-02469-9","DOIUrl":"10.1007/s00787-024-02469-9","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study aims to investigate the evolution and clinical course of psychotic disorders from three large international cohorts of individuals with 22q11.2 deletion syndrome (22q11.2DS) (Tel Aviv, Philadelphia, and Geneva).</p><p><strong>Methods: </strong>We followed 118 individuals with 22q11.2DS from several years before the onset to several years after the onset of psychotic disorders. Data from structured baseline assessment of psychiatric disorders, symptoms of prodrome, indicators and types of psychotic disorders were collected. Additionally, cognitive evaluation was conducted using the age-appropriate Wechsler Intelligence Scale. Electronic medical records were reviewed for medication usage, occupational status, living situation, and psychiatric hospitalizations.</p><p><strong>Results: </strong>At baseline evaluation, the most common psychiatric disorders were anxiety disorder (80%) and attention/deficit hyperactivity disorder (50%). The age of onset of prodromal symptoms and conversion to psychotic disorders were 18.6 ± 6.8 and 20.3 ± 7.2, respectively. The most common prodromal symptoms were exacerbation of anxiety symptoms and social isolation. Of the psychotic disorders, schizophrenia was the most common, occurring in 49% of cases. History of at least one psychiatric hospitalization was present in 43% of participants, and the number of psychiatric hospitalizations was 2.1 ± 1.4. Compared to the normalized chart, IQ scores in our cohort were lower after vs. before conversion to psychosis. Following conversion there was a decrease in the use of stimulants and antidepressants and an increase in antipsychotics use, and most individuals with 22q11.2DS were unemployed and lived with their parents.</p><p><strong>Conclusions: </strong>Our results indicate that 22q11.2DS psychosis is like non-22q11.2DS in its course, symptoms, and cognitive and functional impairments.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"4371-4379"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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