European Child & Adolescent Psychiatry最新文献

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Increased risk of attention-deficit/hyperactivity disorder in adolescents with high salivary levels of copper, manganese, and zinc. 唾液中铜、锰和锌含量高的青少年患注意力缺陷/多动症的风险增加。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-02-14 DOI: 10.1007/s00787-024-02381-2
D'Artagnan M Robinson, Karen L Edwards, Michael T Willoughby, Katrina R Hamilton, Clancy B Blair, Douglas A Granger, Elizabeth A Thomas
{"title":"Increased risk of attention-deficit/hyperactivity disorder in adolescents with high salivary levels of copper, manganese, and zinc.","authors":"D'Artagnan M Robinson, Karen L Edwards, Michael T Willoughby, Katrina R Hamilton, Clancy B Blair, Douglas A Granger, Elizabeth A Thomas","doi":"10.1007/s00787-024-02381-2","DOIUrl":"10.1007/s00787-024-02381-2","url":null,"abstract":"<p><p>Exposure to toxic heavy metals has been associated with the development of attention-deficit/hyperactivity disorder (ADHD). However, fewer studies have examined the associations between abnormal levels of essential trace metals and ADHD, and none have done so using saliva. We investigated whether salivary metals were associated with ADHD in adolescents aged 12 from the Family Life Project (FLP) using a nested case-control study design that included 110 adolescents who met diagnostic criteria for inattentive (ADHD-I), hyperactive-impulsive (ADHD-H), or combined type ADHD (ADHD-C) (cases) and 173 children who did not (controls). We used inductively coupled plasma optical emission spectrophotometry to measure chromium, copper, manganese, and zinc in saliva samples. We employed logistic regression models to examine associations between quartile levels of individual metals and ADHD outcomes by subtype. Salivary copper levels were significantly associated with increased odds of any ADHD diagnosis (OR = 3.31, 95% CI: 1.08-10.12; p = 0.04) and with increased odds of ADHD-C diagnosis (OR = 8.44, 95% CI: 1.58-45.12; p = 0.01). Salivary zinc levels were significantly associated with increased odds of ADHD-C diagnosis (OR = 4.06, 95% CI: 1.21-13.69; p = 0.02). Salivary manganese levels were also significantly associated with increased odds of ADHD-C diagnosis (OR = 5.43, 95% CI: 1.08-27.27, p = 0.04). This is the first study using saliva to assess metal exposure and provide a potential link between salivary levels of copper, manganese, and zinc and ADHD diagnoses in adolescents. Public health interventions focused on metal exposures might reduce ADHD incidence in low-income, minority communities.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3091-3099"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transmission of depressive symptoms in the nuclear family: a cross-sectional and cross-lagged network perspective. 核心家庭中抑郁症状的传播:横截面和跨滞后网络视角。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-02-16 DOI: 10.1007/s00787-024-02377-y
Wenrui Zhang, Ting He, Qinglu Wu, Peilian Chi, Xiuyun Lin
{"title":"Transmission of depressive symptoms in the nuclear family: a cross-sectional and cross-lagged network perspective.","authors":"Wenrui Zhang, Ting He, Qinglu Wu, Peilian Chi, Xiuyun Lin","doi":"10.1007/s00787-024-02377-y","DOIUrl":"10.1007/s00787-024-02377-y","url":null,"abstract":"<p><p>Children are more likely to develop depressive symptoms in families where parents have depressive symptoms. By conceptualizing the individual depressive symptom network of each family member as a whole, this study proposes a family symptom network model, and explored the mechanisms of transmission of depression within nuclear families at the symptom level. This study used four waves (2012, 2016, 2018, 2020) of data from the China Family Panel Studies (CFPS), which in wave one contained a representative sample of 1963 children (1038 boys; age = 12.60), 4763 mothers and 4614 fathers from China. Children with their parents completed the Center for Epidemiology Studies Depression Scale at each wave. Individual depressive symptom networks among children, fathers, and mothers were highly similar and stable across time. When considering depressive symptoms of all family members as a whole, there was a wide range of associations between child, father, and mother depressive symptom networks. The results of the cross-lagged network model suggest the bidirectional relationships between couples and parent-child depression. The current study provides preliminary validation of the family symptom network model. The model represents a further integration and extension of network theory of mental disorders and family systems theory, and points out the limitations of studying the intergenerational transmission of depression from a latent variable perspective. Thus, the family symptom network model proposed in this study could provide valuable new insights into understanding the intergenerational transmission of depression.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3145-3155"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-management, self-care, and self-help in adolescents with emotional problems: a scoping review. 有情绪问题的青少年的自我管理、自我护理和自助:范围界定综述。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2023-01-15 DOI: 10.1007/s00787-022-02134-z
Rosa Town, Daniel Hayes, Anna March, Peter Fonagy, Emily Stapley
{"title":"Self-management, self-care, and self-help in adolescents with emotional problems: a scoping review.","authors":"Rosa Town, Daniel Hayes, Anna March, Peter Fonagy, Emily Stapley","doi":"10.1007/s00787-022-02134-z","DOIUrl":"10.1007/s00787-022-02134-z","url":null,"abstract":"<p><p>This study aimed to review the existing published and grey literature describing the concepts of self-management, self-care, and self-help, and to capture strategies or techniques related to these concepts, for adolescents with emotional problems. Emotional problems are rising amongst adolescents, yet timely access to specialist mental health treatment is limited to those with greater severity of mental health difficulties. Self-management, self-care, and self-help strategies may be used by adolescents with emotional problems both in terms of those waiting for treatment and to prevent relapse. Given the overlap in existing definitions and the lack of clarity around these concepts in an adolescent mental health context, a scoping review of the literature is warranted to provide clarity. Eligible studies were those involving adolescents aged 10 to 19 years with symptoms of emotional problems. Studies referenced self-management, self-care, or self-help, not involving a professional, in this population. Quantitative, qualitative, economic, and mixed methods studies, as well as systematic, scoping, and literature reviews, from 2000 onwards and in the English language, were eligible for inclusion. A systematic search was conducted of both published and grey literature. Databases searched included PsycINFO, Medline, Embase, Web of Science, and CINAHL Plus. Mednar was also searched for unpublished studies and grey literature. Tables  of themes, terms, and associated strategies are presented alongside a thematic analysis of the results. 62 articles were included. These were 20 quantitative studies, 14 systematic reviews, 10 qualitative studies, five review papers, four book chapters, four mixed methods studies, two dissertations, two meta-analyses and one scoping review and systematic review. Most of the included articles referenced self-help (n = 51), followed by self-management (n = 17) and self-care (n = 6). A total of 12 themes were identified from a reflexive thematic analysis of descriptions (and associated strategies) of self-management, self-help, or self-care in included texts. This scoping review provides clarity on the similarities and differences between how these concepts are discussed, and the strategies which are associated with each of these concepts in the relevant literature. Implications for policy and intervention development for adolescents' self-management, self-help, and self-care of their mental health are discussed. There is considerable overlap in both the ways in which these concepts are described, and the strategies or approaches proposed in relation to them, supporting previous research suggesting these strategies should be grouped under a single term, such as \"self or community approaches.\" More research is needed for self-management, self-help, and self-care amongst marginalized groups as these adolescents may have the highest unmet need for mental health support.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2929-2956"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9104896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between maternal employment and the child´s mental health: a systematic review with meta-analysis. 母亲就业与儿童心理健康之间的关系:系统回顾与荟萃分析。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2023-02-13 DOI: 10.1007/s00787-023-02164-1
Marie Kopp, Marina Lindauer, Susan Garthus-Niegel
{"title":"Association between maternal employment and the child´s mental health: a systematic review with meta-analysis.","authors":"Marie Kopp, Marina Lindauer, Susan Garthus-Niegel","doi":"10.1007/s00787-023-02164-1","DOIUrl":"10.1007/s00787-023-02164-1","url":null,"abstract":"<p><p>The recent rise in maternal workforce participation has led to more research regarding the role of maternal employment for (early) childhood mental health. This systematic review with meta-analysis covers new evidence on the association of both variables. A systematic literature search was conducted. Studies had to compare children 0-7 years of age on the basis of their mothers' employment status, working amount, employment duration, i.e., how long the mother had been back at work after birth, or timing of return to work. Child mental health was operationalized as behavior problems and prosocial behavior. Narrative and meta-analytic syntheses of evidence were conducted. Maternal employment was associated with more conduct problems but less internalizing behavior problems and anxious/depressed behavior in children; full-time employment was linked to more externalizing behavior problems and more hyperactivity/inattention. Longer employment duration was related to less (internalizing) behavior problems and more prosocial behavior but also more externalizing behavior problems. Narrative syntheses indicated early maternal return to work to be associated with more child externalizing behavior problems and less prosocial behavior. Whether maternal employment is associated with child mental health strongly depends on both variables' operationalization. Especially part-time employment, longer employment duration, and return to work only after the first year postpartum may be beneficial for child mental health. Practical implications pertain to an expanded offer of family leave and the endorsement of maternal employment after the first year postpartum. Here, factors that may buffer the negative associations with full-time employment warrant consideration.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3025-3042"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10715963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of poverty and adversity on perceived family support in adolescence: findings from the UK Millennium Cohort Study. 贫困和逆境对青少年时期家庭支持感的影响:英国千年队列研究的发现。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-02-14 DOI: 10.1007/s00787-024-02389-8
Nicholas Kofi Adjei, Kenisha Russell Jonsson, Viviane S Straatmann, Gabriella Melis, Ruth McGovern, Eileen Kaner, Ingrid Wolfe, David C Taylor-Robinson
{"title":"Impact of poverty and adversity on perceived family support in adolescence: findings from the UK Millennium Cohort Study.","authors":"Nicholas Kofi Adjei, Kenisha Russell Jonsson, Viviane S Straatmann, Gabriella Melis, Ruth McGovern, Eileen Kaner, Ingrid Wolfe, David C Taylor-Robinson","doi":"10.1007/s00787-024-02389-8","DOIUrl":"10.1007/s00787-024-02389-8","url":null,"abstract":"<p><p>Emotional support from family members may have an important effect on adolescent health outcomes, and has been identified as a target for policy to protect against the impacts of poverty and other early life adversities. However, few studies have assessed the extent to which poverty and adversity themselves influence the nature of emotional support that parents can provide to adolescents. We, therefore, aimed to investigate the impact of trajectories of income poverty and family adversities, including parental mental ill health, alcohol misuse and domestic violence across childhood developmental stages on young people's relationships with their families and perceived emotional support received. We analysed longitudinal data on 10,976 children from the nationally representative UK Millennium Cohort study. Exposure trajectories of poverty and family adversities were characterised using group-based multi-trajectory models (age 9 months-14 years). The outcomes were perceived emotional support and quality of family relationships, measured by the three-item Short Social Provisions Scale (SPS-3) and levels of parent-adolescent closeness and conflict, measured at age 14. ORs and 95% CIs were estimated using multivariable logistic regression models, adjusting for potential confounding factors. At age 14, the overall prevalence of low perceived emotional support was 13% (95% CI: 12, 14). Children of mothers with lower socioeconomic status (SES) were more likely to report low emotional support, with a clear social gradient (education-degree plus: 10.3% vs. no qualifications: 15.4%). Compared with children exposed to low levels of poverty and adversity, children in the persistent adversity trajectory groups experienced higher odds of low emotional support and low-quality parent-adolescent relationship; those exposed to both persistent poverty and poor parental mental health were particularly at increased risk of experiencing poor family relationships and low perceived emotional support (adjusted odds ratio 2·2; 95% CI 1·7-2·9). Low perceived emotional support and poor family relationships in adolescence are more prevalent among socially disadvantaged children and adolescents and those experiencing social adversity. Policies to improve levels of family support for UK adolescents should focus on improving modifiable determinants such as child poverty and family mental health.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3123-3132"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and quality of life of 11-15-year-old adolescent young carers in France: a school-based study. 法国 11-15 岁青少年照顾者的普遍性和生活质量:一项以学校为基础的研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-02-14 DOI: 10.1007/s00787-024-02383-0
Jade Pilato, Géraldine Dorard, Aurélie Untas
{"title":"Prevalence and quality of life of 11-15-year-old adolescent young carers in France: a school-based study.","authors":"Jade Pilato, Géraldine Dorard, Aurélie Untas","doi":"10.1007/s00787-024-02383-0","DOIUrl":"10.1007/s00787-024-02383-0","url":null,"abstract":"<p><p>Our study aimed to establish the prevalence of adolescent young carers (AYCs) among 11-15-year-old French adolescents and explore the impacts of caring on these youths through a comprehensive evaluation of their quality of life. A total of 1983 middle school pupils (mean age = 12.89; 56.23% females) completed self-reported questionnaires evaluating their sociodemographic characteristics, illness/disability in their family, caring activities (MACA-YC18), quality of life (KIDSCREEN-52), perceived health, and academic performance. Descriptive analyses, Chi-square tests of independence, Student's t-tests, and analysis of variance and of covariance were conducted. The results showed that 12.25% of middle school pupils were AYCs. They were mostly females, coming from disadvantaged economic backgrounds. The ill/disabled relative was typically a parent, and 23.87% of respondents reported having more than one ill/disabled relative. The AYCs more often declared an illness or a disability and reported lower quality of life scores than their peers in several dimensions: Physical Well-Being, Psychological Well-Being, Moods and Emotions, Self-Perception, Autonomy, Relations with Parents and Home Life, Financial Resources, School Environment, Social Acceptance. No differences were identified in the Social Support and Peers dimension. Given the high prevalence of AYCs in middle schools and the impact of the situation on their lives, special support should be provided for AYCs, and professionals at school should be trained to better identify and assist AYCs.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3101-3110"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of transcranial direct current stimulation in children and young people with psychiatric disorders: a systematic review. 经颅直流电刺激对患有精神障碍的儿童和青少年的影响:系统性综述。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2023-02-11 DOI: 10.1007/s00787-023-02157-0
Lucy Gallop, Samuel J Westwood, Yael Lewis, Iain C Campbell, Ulrike Schmidt
{"title":"Effects of transcranial direct current stimulation in children and young people with psychiatric disorders: a systematic review.","authors":"Lucy Gallop, Samuel J Westwood, Yael Lewis, Iain C Campbell, Ulrike Schmidt","doi":"10.1007/s00787-023-02157-0","DOIUrl":"10.1007/s00787-023-02157-0","url":null,"abstract":"<p><p>Transcranial direct current stimulation (tDCS) has demonstrated benefits in adults with various psychiatric disorders, but its clinical utility in children and young people (CYP) remains unclear. This PRISMA systematic review used published and ongoing studies to examine the effects of tDCS on disorder-specific symptoms, mood and neurocognition in CYP with psychiatric disorders. We searched Medline via PubMed, Embase, PsychINFO via OVID, and Clinicaltrials.gov up to December 2022. Eligible studies involved multiple session (i.e., treatment) tDCS in CYP (≤ 25 years old) with psychiatric disorders. Two independent raters assessed the eligibility of studies and extracted data using a custom-built form. Of 33 eligible studies (participant N = 517), the majority (n = 27) reported an improvement in at least one outcome measure of disorder-specific symptoms. Few studies (n = 13) examined tDCS effects on mood and/or neurocognition, but findings were mainly positive. Overall, tDCS was well tolerated with minimal side effects. Of 11 eligible ongoing studies, many are sham-controlled RCTs (n = 9) with better blinding techniques and a larger estimated participant enrolment (M = 79.7; range 15-172) than published studies. Although encouraging, the evidence to date is insufficient to firmly conclude that tDCS can improve clinical symptoms, mood, or cognition in CYP with psychiatric disorders. Ongoing studies appear of improved methodological quality; however, future studies should broaden outcome measures to more comprehensively assess the effects of tDCS and develop dosage guidance (i.e., treatment regimens).</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3003-3023"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9162027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional bullying and cyberbullying in the digital age and its associated mental health problems in children and adolescents: a meta-analysis. 数字时代的传统欺凌和网络欺凌以及与之相关的儿童和青少年心理健康问题:荟萃分析。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2022-12-31 DOI: 10.1007/s00787-022-02128-x
Chao Li, Ping Wang, Marina Martin-Moratinos, Marcos Bella-Fernández, Hilario Blasco-Fontecilla
{"title":"Traditional bullying and cyberbullying in the digital age and its associated mental health problems in children and adolescents: a meta-analysis.","authors":"Chao Li, Ping Wang, Marina Martin-Moratinos, Marcos Bella-Fernández, Hilario Blasco-Fontecilla","doi":"10.1007/s00787-022-02128-x","DOIUrl":"10.1007/s00787-022-02128-x","url":null,"abstract":"<p><p>Bullying is a risk factor for the physical and mental health of adolescents. The advent of new technologies has resulted in a brand-new type of bullying, cyberbullying (CB). The co-occurring effects of cyberbullying and traditional bullying(TB) forms of bullying on adolescent mental health are unclear. We performed a meta-analysis to explore the unique and combined effects of CB and TB on adverse psychological outcomes in victims by conducting a joint study of both types of bullying. By doing so, we provide the basis for a comprehensive community bullying prevention program. The database PubMed, PsyclNFO, and Web of Science were searched for studies from 2010 to 2021. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was followed for data abstraction, and the NIH tool was used to evaluate study-level risk of bias. 42 studies with 266,888 participants were identified. Random-Effect models were used for our study. The moderator analysis was used to explore the moderator of prevalence. Studies with three groups of victims (TB only, CB only, and Both) and two groups of victims (TB and CB) were compared in subgroup analysis. The mean victimization rate was 24.32% (95% CI 20.32-28.83%) for TB and 11.10% (95% CI 9.12-13.44%) for CB. Roughly one-third of TB victims were also victimized by CB. Conversely, only about one-third of CB victims were free from TB. The estimated ORs for depression, suicidal ideation, suicide attempts, and self-harm in the three-group (TB only, CB only and Both) analysis were: depression [TB only: 3.33 (2.22-5.00); CB only: 3.38 (2.57-4.46); Both: 5.30 (2.43-11.56)]; suicidal ideations [TB only: 3.08 (2.12-4.46); CB only: 3.52 (2.38-5.20); Both: 6.64 (4.14-10.64)]; self-harm [TB only: 2.70 (1.86-3.91); CB only: 3.57 (3.20-3.98); Both: 5.57 (2.11-16.00)]; and suicide attempts: [TB only: 2.61 (1.50-4.55); CB only: 3.52 (2.50-4.98); Both: 7.82 (3.83-15.93)]. TB and CB victimization among youth are a matter of public health concern. Victimization appears to be a marker of greater psychopathological severity, particularly suicide-related issues.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2895-2909"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis. 作为自闭症谱系障碍生物标志物的 miRNAs:系统综述与荟萃分析。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2023-02-03 DOI: 10.1007/s00787-023-02138-3
Nathalia Garrido-Torres, Karem Guzmán-Torres, Susana García-Cerro, Gladys Pinilla Bermúdez, Claudia Cruz-Baquero, Hansel Ochoa, Diego García-González, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
{"title":"miRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis.","authors":"Nathalia Garrido-Torres, Karem Guzmán-Torres, Susana García-Cerro, Gladys Pinilla Bermúdez, Claudia Cruz-Baquero, Hansel Ochoa, Diego García-González, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla","doi":"10.1007/s00787-023-02138-3","DOIUrl":"10.1007/s00787-023-02138-3","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex clinical manifestations that arise between 18 and 36 months of age. Social interaction deficiencies, a restricted range of interests, and repetitive stereotyped behaviors are characteristics which are sometimes difficult to detect early. Several studies show that microRNAs (miRs/miRNAs) are strongly implicated in the development of the disorder and affect the expression of genes related to different neurological pathways involved in ASD. The present systematic review and meta-analysis addresses the current status of miRNA studies in different body fluids and the most frequently dysregulated miRNAs in patients with ASD. We used a combined approach to summarize miRNA fold changes in different studies using the mean values. In addition, we summarized p values for differential miRNA expression using the Fisher method. Our literature search yielded a total of 133 relevant articles, 27 of which were selected for qualitative analysis based on the inclusion and exclusion criteria, and 16 studies evaluating miRNAs whose data were completely reported were ultimately included in the meta-analysis. The most frequently dysregulated miRNAs across the analyzed studies were miR-451a, miR-144-3p, miR-23b, miR-106b, miR150-5p, miR320a, miR92a-2-5p, and miR486-3p. Among the most dysregulated miRNAs in individuals with ASD, miR-451a is the most relevant to clinical practice and is associated with impaired social interaction. Other miRNAs, including miR19a-3p, miR-494, miR-142-3p, miR-3687, and miR-27a-3p, are differentially expressed in various tissues and body fluids of patients with ASD. Therefore, all these miRNAs can be considered candidates for ASD biomarkers. Saliva may be the optimal biological fluid for miRNA measurements, because it is easy to collect from children compared to other biological fluids.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2957-2990"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk and protective factors of suicidal tendencies among freshmen in China revealed by a hierarchical regression model. 分层回归模型揭示中国大一新生自杀倾向的风险和保护因素。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2024-09-01 Epub Date: 2024-02-07 DOI: 10.1007/s00787-024-02370-5
Zhongrui Wang, Xiyu Li, Haiyu Xu, Tao Zhang
{"title":"Risk and protective factors of suicidal tendencies among freshmen in China revealed by a hierarchical regression model.","authors":"Zhongrui Wang, Xiyu Li, Haiyu Xu, Tao Zhang","doi":"10.1007/s00787-024-02370-5","DOIUrl":"10.1007/s00787-024-02370-5","url":null,"abstract":"<p><p>This study aimed to identify risk and protective factors for suicidal tendencies among college students by exploring current mental health, personal experiences, family environment, and school adaptation. A total of 11,504 freshmen in China were recruited. Suicidal tendencies were assessed using the Adolescents Suicidal Tendencies Scale (ASTS), while explored risk and protective factors included mental health assessed by the Symptom Checklist-90 (SCL-90), campus adaptation using the College Student School Adaptation Scale, and Personal Situation Survey. Single-factor Logistic regression analysis, correlation analysis, and hierarchical regression analysis were used to analyze the risk and protective factors affecting suicidal tendencies. The results showed that in terms of personal experience, self-injury behavior (OR = 3.522, 95% CI [3.256, 3.811]), sexual assault experience (OR = 2.603, 95% CI [2.374, 2.855]) and lack of friendship relationship (OR = 2.249, 95% CI [2.076, 2.436]) were the most significant risk factors. Regarding family environment, parenting style (OR = 2.455, 95% CI [2.272, 2.652]), parent-child relationship (OR = 2.255, 95% CI [2.092, 2.429]) and violent conflict (OR = 2.164, 95% CI [2.015, 2.324]) were the most prominent risk factors. For protective factors, life satisfaction (OR = 0.330, 95% CI [0.304, 0.359]) and rest quality (OR = 0.415, 95% CI [0.386, 0.447]) were the most significant protective factors. In addition, Symptom Checklist-90 was positively correlated with suicidal tendencies (r = 0.541, 95% CI [0.522, 0.560], p < 0.001), while school adaptation was negatively correlated with suicidal tendencies (r = - 0.590, 95% CI [- 0.579, - 0.601], p < 0.001). After considering demographic variables, psychological symptoms, school adaptation and other risk and protective factors, the hierarchical regression model could explain 48.9% of the variance of suicidal tendencies. The study emphasizes a range of multidimensional risk and protective factors for suicidal tendencies. This enhanced understanding is crucial in aiding the design of future intervention studies targeted at improving the mental health of college students.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3043-3053"},"PeriodicalIF":6.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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