European Child & Adolescent Psychiatry最新文献

{"title":"Disrupted profiles of interoception and mental health in youths: a systematic review.","authors":"Hanna Mayer-Benarous, Xavier Benarous, Marion Robin","doi":"10.1007/s00787-025-02705-w","DOIUrl":"10.1007/s00787-025-02705-w","url":null,"abstract":"<p><p>Although sensory integration impairment and atypical bodily perception were long-lasting described in youths with psychopathology, the contribution of interoceptive deficits in pediatric mental health problems remains poorly understood. A systematic search of PubMed, Medline, Cochrane, Psycinfo, and reference lists of the included studies was conducted for articles up to November 2024. Attention was paid to distinguishing objective performance on behavioral tests (i.e., interoceptive accuracy, IAc), subjective self-assessment of competence (i.e., interoceptive sensibility, ISe), the congruence level between objective performance and subjective self-assessment (i.e., interoceptive awareness, IAw) and beliefs on interoception (interoceptive metacognition, IMe). The quality of studies was assessed using a modified version of the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. Of the 761 citations initially identified, 24 studies were finally included. IAc appeared reduced in youths with neurodevelopmental disorders, with mitigated findings regarding anxiety symptoms. ISe were positively correlated with the severity of anxiety and depressive symptoms in pediatric samples. The domain of IMe was particularly impaired among youths with eating disorder symptoms. The review identified few and highly heterogeneous studies. Such preliminary findings support the importance of accounting for different constructs related to interoception and including a trans-nosographical framework of psychopathology to explore these relations.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2279-2295"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder.","authors":"Xiuxian Li, Shengjuan Wu, Wenzhong Yang, Chengcheng Jiang, Zhiwei Zhao, Hong Wang, Fuchun Lin","doi":"10.1007/s00787-025-02651-7","DOIUrl":"10.1007/s00787-025-02651-7","url":null,"abstract":"<p><p>Emerging evidence suggests aberrant functional connectivity (FC) of brain networks in children, adolescents, and adults with autism spectrum disorder (ASD). However, little is known about alterations of dynamic FC in toddlers with ASD. The aim of this study was to investigate the characteristics of brain network dynamics in ASD toddlers. We analyzed resting-state functional magnetic resonance imaging data of 41 ASD and 23 typically-developing (TD) toddlers aged 15-45 months using leading eigenvector dynamics analysis. The between-group differences in the temporal properties of state were evaluated, followed by correlation analysis of these differences with autistic factors in ASD. Compared with TD subjects, ASD toddlers had a lower occurrence rate and mean dwell time in the global state. The mean dwell time of this state was negatively correlated with the body and object use of the autism behavior checklist (ABC) score. The ASD group presented a higher occurrence probability in the state related to the visual network, and the dwell time of this state was positively correlated with the relationship building of the ABC score. Moreover, the occurrence probability of the state related to the dorsal attention network and default mode network was positively correlated with the body and object use of the ABC score. Our findings indicate that there are differences in the developmental patterns of large-scale brain functional networks in ASD toddlers, which may contribute to the early identification of ASD and provide meaningful insights into its potential neural mechanisms.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2391-2401"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Abnormal resting-state brain network dynamics in toddlers with autism spectrum disorder.","authors":"Xiuxian Li, Shengjuan Wu, Wenzhong Yang, Chengcheng Jiang, Zhiwei Zhao, Hong Wang, Fuchun Lin","doi":"10.1007/s00787-025-02658-0","DOIUrl":"10.1007/s00787-025-02658-0","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2403"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.","authors":"Mélanie Bouliane, Michel Boivin, Tina Kretschmer, Bianca Lafreniere, Stéphane Paquin, Richard Tremblay, Sylvana Côté, Jean-Philippe Gouin, Till F M Andlauer, Amélie Petitclerc, Isabelle Ouellet-Morin","doi":"10.1007/s00787-025-02654-4","DOIUrl":"10.1007/s00787-025-02654-4","url":null,"abstract":"<p><p>Individual differences in physical aggression (PA) are largely heritable. However, it remains unclear how genetic propensity for aggression manifests early in life and relates to school-age PA. Preschool externalizing behavior problems (EXT) and adverse experiences are known predictors of school-age PA and also partly heritable. We investigated whether early childhood EXT and adverse experiences mediated the association between polygenic scores and school-age PA. Genotype data collected from 721 participants in the Quebec Longitudinal Study of Child Development (45% males) were used to derive polygenic scores for aggression (PGS_AGG) and attention deficit/hyperactivity disorder (PGS_ADHD). PA was reported annually or biennially on six occasions between ages 6 and 13 by distinct teachers. Mothers reported EXT (PA, hyperactivity, opposition) and adverse experiences (peer difficulties and harsh parenting) on three occasions between ages 3½ and 5. Both PGSs proved significant predictors of school-age PA. However, no early behaviors or adverse experiences mediated the association between PGS_AGG and school-age PA. Contrastingly, hyperactivity and opposition each partially mediated the association between PGS_ADHD and school-age PA. Notably, when both mediators were included in the same model, only hyperactivity remained significant. This study contributes to identifying early manifestations of genetic risk for PA, which may serve as early targets for intervention.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2443-2451"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocal relationships between adolescent mental health difficulties and alcohol consumption.","authors":"Janet Kiri, James Hall, Samuele Cortese, Valerie Brandt","doi":"10.1007/s00787-025-02644-6","DOIUrl":"10.1007/s00787-025-02644-6","url":null,"abstract":"<p><p>The directionality of the relationship between adolescent alcohol consumption and mental health difficulties remains poorly understood. This study investigates the longitudinal relationship between alcohol use frequency, internalizing and externalizing symptoms from the ages of 11 to 17. We conducted a random-intercept cross-lagged panel model across three timepoints (ages: 11yrs, 14yrs, 17yrs; 50.4% female) in the Millennium Cohort Study (N = 10,647). Survey weights were used to account for attrition. At each timepoint, past month alcohol use frequency was self-reported, parents and cohort members reported internalizing/externalizing symptoms using the Strengths and Difficulties Questionnaire. We controlled for alcohol expectancies, sex, and four cumulative risk indices (perinatal risk, early childhood adverse parenting, longitudinal parent-level risk occurrence, and persistent household socioeconomic deprivation). More frequent past month alcohol use at age 11 predicted increased internalizing symptoms at age 14 (β = 0.06; p =.01). More frequent past month alcohol use at age 14 predicted increased externalizing symptoms at age 17 (β = 0.11; p <.001). Increased internalizing symptoms consistently predicted reduced alcohol use at the next timepoint throughout the study period (11 years: β= -0.04; p =.03; 14 years: β= -0.09; p <.001). Increased externalizing symptoms at age 11 predicted increased alcohol consumption at age 14 (β = 0.06; p =.004). Frequent adolescent alcohol consumption represents a significant risk for subsequent mental health difficulties. Externalizing symptoms and alcohol use frequency appear to exacerbate one another. Internalizing symptoms may reduce the risk of frequent alcohol consumption. Incorporating routine alcohol screening into adolescent mental health treatment settings could reduce the risk of comorbid externalizing and alcohol use disorders.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2347-2357"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence rate of perceived gender discrimination and its associations with suicide behaviors in Chinese adolescents: the mediating roles of depressive symptoms and anxiety symptoms.","authors":"Yanzhi Li, Keying Wu, Wenjian Lai, Wanxin Wang, Hao Zhao, Caiyun Zhang, Lan Guo, Ciyong Lu","doi":"10.1007/s00787-025-02674-0","DOIUrl":"10.1007/s00787-025-02674-0","url":null,"abstract":"<p><p>This cross-sectional study aimed to investigate the prevalence rate of perceived gender discrimination and its associations with suicidal ideation and suicide attempts, as well as the mediating roles of depressive symptoms and anxiety symptoms in Chinese adolescents. From October 2021 to March 2022, we adopted a multi-stage stratified cluster random sampling method to recruit students from grades 7-12 in China. A total of 79,211 adolescents aged 10-19 years from eight provinces completed the survey with valid data for the current study. Data were weighted to adjust for unequal probabilities of selection and differential response as well as to post-stratify the sample to match the population distribution. The weighted prevalence rate of perceived gender discrimination was 3.5% in Chinese adolescents, with girls having a higher prevalence rate than boys (5.5% vs.1.7%; P-value < 0.001). In the full-adjusted model, perceived gender discrimination was associated with a higher likelihood of suicidal ideation (OR, 2.16; 95% CI, 1.93-2.42) and suicide attempts (OR, 1.62; 95% CI, 1.39-1.88). Mediation analyses showed that depressive symptoms and anxiety symptoms significantly mediated 39.5% and 5.7% of the association between perceived gender discrimination and suicidal ideation, respectively, and depressive symptoms and anxiety symptoms significantly mediated 54.3% and 7.0% of the association between perceived gender discrimination and suicide attempts, respectively. These findings suggest the need for targeted interventions to reduce gender discrimination against adolescents, especially girls, which might help prevent their suicidal behaviors and mental health problems.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2473-2483"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in internalizing and externalizing problems in Dutch children and adolescents receiving outpatient youth care before and during the COVID-19 pandemic.","authors":"Emma M Broek, Ronald De Meyer, Rachel van der Rijken, Josjan Zijlmans, Hedy A van Oers, Michiel A J Luijten, Hekmat Alrouh, Arne Popma, Meike Bartels, Robert R J M Vermeiren, Tinca J C Polderman, Jacintha M Tieskens","doi":"10.1007/s00787-025-02665-1","DOIUrl":"10.1007/s00787-025-02665-1","url":null,"abstract":"<p><p>The COVID-19 pandemic significantly impacted the mental health of children and adolescents, but its effects on treatment outcomes in youth care remain unclear. This study examines whether the pandemic influenced treatment outcomes for internalizing and externalizing problems in children receiving outpatient youth care. We analyzed data from three groups of children who received outpatient youth care (N = 1090, M_age = 12.85): those treated entirely before the pandemic, those who transitioned into pandemic-related measures during treatment, and those treated entirely during the pandemic. The Child Behavior Checklist was used to assess internalizing and externalizing problems at the start and end of treatment. Repeated measures ANCOVAs and χ² tests of independence were conducted to evaluate changes in problem severity and clinical status, and ANCOVAs were used to compare between-group differences. The results suggest that while overall treatment outcomes were not directly affected by the pandemic, fewer children treated during the pandemic recovered from externalizing problems compared to those treated before the pandemic. Additionally, children treated entirely during the pandemic exhibited higher levels of internalizing and externalizing problems at both the start and end of treatment, and those transitioning into the pandemic also had elevated externalizing problems at both time points. Although the pandemic did not affect the change in problems during treatment, the increased severity of issues at both the start and end of treatment indicates a deterioration in child mental health since the pandemic. Appropriate support, preventive interventions, and regular monitoring of mental health problems may mitigate future impacts.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2521-2533"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential association between stimulant or atomoxetine use and suicidal or self-injurious behaviors in children with attention deficit hyperactivity disorder: real-world insights from the FAERS database.","authors":"Jinhua Liu, Liping Xue, Fanxiang Zeng, Ying Liu, Yanting Zhu, Jintuo Zhou, Jinhua Zhang, Huajiao Chen","doi":"10.1007/s00787-025-02694-w","DOIUrl":"10.1007/s00787-025-02694-w","url":null,"abstract":"<p><p>This study aims to investigate the potential correlation between commonly prescribed attention-deficit/hyperactivity disorder (ADHD) medications and suicidal or self-injurious behaviors (SSIBs) among the pediatric population by exploring the FDA Adverse Event Reporting System (FAERS) database. The FAERS database (2004Q1-2023Q4) was queried and SSIBs cases associated with stimulants (methylphenidate, and amphetamine) or atomoxetine were identified. The signals for SSIBs were analyzed using disproportionate methods, and the accuracy of the results was validated through sensitivity analysis with multifactor logistic regression. Time-to-onset analysis explored factors affecting SSIBs manifestation. Disproportionality analysis revealed a significant negative association between methylphenidate and SSIBs, while atomoxetine exhibited a significant positive correlation with SSIBs. The frequency of SSIBs was lower with stimulants alone or with the combined use of stimulants and atomoxetine compared to atomoxetine alone. Time-to-onset analysis indicated that all cases were of the early failure type, with the median time to onset of SSIBs associated with atomoxetine occurring later than that linked to stimulants. Stratification by age showed that in the stimulant group, the median time to SSIBs was longer for patients aged 13-17 years compared to those aged 6-12 years. Conversely, the opposite trend was observed in the atomoxetine group. The observed differences in time to onset highlight the importance of individualized screening for SSIBs across various populations, ultimately improving patient outcomes in the follow-up of stimulants or atomoxetine recipients.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2585-2597"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk factors for the comorbidity of depression and self-injury in adolescents: a machine learning study.","authors":"Yuancheng Huang, Yanli Hou, Caina Li, Ping Ren","doi":"10.1007/s00787-025-02672-2","DOIUrl":"10.1007/s00787-025-02672-2","url":null,"abstract":"<p><p>There has been a growing concern in utilizing machine learning models to identify risk factors for adolescent mental health. However, the comorbidity domain has not received adequate attention. Accordingly, this study aims to develop an efficient machine leaning model to predict the comorbidity of depression and self-injury among adolescents. 1,028,751 Chinese adolescents completed measures of depression, self-injury, and a range of items related to sociodemographic and psychosocial variables. We evaluated the performance of six machine learning models and established the optimal model for identifying the comorbidity of depression and self-injury. We selected the Top-N variable set corresponding to a cumulative probability of 80% for the optimal model to establish a risk model for the comorbidity of depression and self-injury in adolescents. The combined model of Random Forest and LightGBM can effectively identify adolescents with comorbidity risk based on 13 variables. Specifically, the predictive power of individual characteristics significantly outweighs environmental factors; within individual characteristics, emotional problems (anxiety) exhibit the strongest predictive power; among environmental factors, parental emotional maltreatment and cyber victimization demonstrate the highest predictive effect. This study extends the application of the Bioecological Model in the field of comorbidity research, demonstrating the advantages of using machine learning methods to predict comorbidity of depression and self-injury in adolescents. It holds practical value for preventing and intervening in comorbidity of depression and self-injury among adolescents.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2485-2496"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the longitudinal bi-directional relationship between self-reported restrictive eating behaviours and sleep in UK adolescents within the Millennium Cohort Study.","authors":"Marie-Christine Opitz, Giulia Gaggioni, Nora Trompeter, Francisco Diego Rabelo-da-Ponte, Sylvane Desrivières, Nadia Micali, Ulrike Schmidt, Helen Sharpe","doi":"10.1007/s00787-025-02641-9","DOIUrl":"10.1007/s00787-025-02641-9","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the longitudinal bi-directional relationship between self-reported restrictive eating behaviours and sleep characteristics within a sample of UK adolescents from the Millennium Cohort Study (MCS).</p><p><strong>Method: </strong>Using a Structural Equation Modelling approach, the present study investigated the prospective associations between individual sleep behaviours (e.g., sleep timing, sleep onset latency, social jetlag) at age 14 and restrictive eating behaviours at age 17. Moreover, the association between restrictive eating behaviours (age 14) and self-reported sleep quality (age 17) was tested. A mediation analysis was conducted to explore the role of depressive symptoms in these relationships. In total, N = 6,041 young people provided self-report data at both timepoints (sweep 6 & 7) and a subsample of N = 2,164 additionally provided diary data on their sleep behaviours over two separate 24 h periods.</p><p><strong>Results: </strong>Sleep indicators at age 14 did not significantly predict changes in restrictive eating behaviours across time. However, engagement in restrictive eating behaviours at age 14 significantly predicted poorer self-perceived sleep quality three years later (β = 0.06, SE = 0.01, p <.01). Depressive symptoms fully mediated this relationship (indirect effect: β = 0.05, SE = 0.04, p <.001).</p><p><strong>Discussion: </strong>The present study provides evidence for a prospective positive association between restrictive eating behaviours and subsequent poorer sleep quality in a large, general population sample. Findings of the mediation analysis suggest mood as a potential target for tertiary prevention when addressing restrictive eating behaviours as an eating disorder risk factor in adolescents.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2405-2416"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}