Environmental Toxicology and Chemistry最新文献

{"title":"Integrated analysis of lethal and sublethal effects of rice pesticides on the natural predator Microvelia Pulchella (Insecta: Hemiptera: Veliidae): insights into direct and indirect effects.","authors":"Arledys Albino-Bohórquez, Yeisson Gutiérrez, German Bohórquez, Tito Bacca","doi":"10.1093/etojnl/vgaf076","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf076","url":null,"abstract":"<p><p>This study examines the lethal and sublethal effects of commonly used rice crop pesticides-cypermethrin, butachlor, and carbendazim-on the broad-shouldered water strider, Microvelia pulchella. Conducted under controlled conditions, the research aimed to elucidate the direct and indirect impacts of these pesticides on key life-history traits of this aquatic predatory insect. Initial dose-response bioassays revealed that cypermethrin was the most toxic, with a median lethal concentration (LC50) of 0.79 ppm, followed by butachlor (LC50 = 2.53 ppm) and carbendazim (LC50 = 15.63 ppm). Subsequently, using Structural Equation Modelling (SEM), we investigated causal relationships between sublethal pesticide exposure and life-history traits in M. pulchella. The results demonstrated that sublethal concentrations induced significant biological disruptions, with pronounced sex-specific effects on wing development, body size, longevity, fecundity, and offspring hatching success. Cypermethrin exposure markedly reduced female body size and longevity in both sexes, indirectly diminishing egg production and offspring hatching success. Butachlor similarly reduced body size in both sexes and male longevity, with cascading effects on reproductive output. Specifically, decreased egg production was linked to smaller female body size, reduced male longevity, and an indirect effect of butachlor on female longevity mediated by body size. In contrast, carbendazim exposure led to reductions in body size and significant impairments in wing development. Its effects on fertility, however, were dose-dependent, showing a slight decline at lower concentrations but an unexpected increase at higher doses, suggesting a complex, non-linear relationship between exposure levels and reproductive outcomes. These findings highlight the detrimental ecological consequences of cypermethrin, butachlor, and carbendazim on M. pulchella, disrupting its role as a natural predator and impairing its ability to regulate pest populations. The study concludes with evidence-based recommendations for Integrated Pest Management (IPM) practices and regulatory policies aimed at preserving beneficial predatory species like M. pulchella and fostering sustainable agricultural systems.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring cumulative effects of aquaculture chemicals in sediment on adult sea urchin behavioural, immunological, and metabolomic endpoints.","authors":"Davide Asnicar, Lauren Jonah, Benjamin de Jourdan, Dounia Hamoutene","doi":"10.1093/etojnl/vgaf080","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf080","url":null,"abstract":"","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Stepwise Prioritization of Chemicals Detected in Great Lakes Tributaries (2008-2018).","authors":"E M Maloney, S R Corsi, M A Pronschinske, L A DeCicco, J R Frisch, N Fuller, A K Baldwin, K Kimbrough, M Edwards, S L Hummel, N Vinas, D L Villeneuve","doi":"10.1093/etojnl/vgaf069","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf069","url":null,"abstract":"<p><p>Through the U.S. Great Lakes Restoration Initiative, a ten-year, multi-agency chemical monitoring effort was undertaken across the Great Lakes. In this effort 586 chemicals were monitored and 334 were detected in grab/composite water samples. To help inform potential future actions, a stepwise prioritization framework was used to identify compounds for which publicly accessible water quality guidelines or effects information suggested there was potential aquatic ecotoxicity. As water quality guidelines were only available for some chemicals, this framework also used apical toxicity data collated from publicly accessible databases (e.g., the ECOTOXicology Knowledgebase). It also used alternative data, including literature-derived non-apical effect concentrations, in vitro bioactivities from high throughput screening, and modeled ecotoxicity. To account for the diverse levels of confidence in these data, chemicals were prioritized within specific action categories, which suggested potential management or experimental activities that may be considered based on the types of data available for each compound. Overall, 11 detected chemicals were identified as high priority in different action categories. This included 4 chemicals prioritized for environmental management or targeted risk assessment, 3 chemicals prioritized for effects-based monitoring, 1 chemical prioritized for apical effects assessment and 3 chemicals targeted for non-apical evaluation. This framework also identified 164 low priority chemicals, among which over 50% were prioritized based on water quality guidelines or apical effect concentrations (thus could be considered low priority for future risk assessment or management activities). Results aim to help regulatory agencies, environmental managers, and other stakeholders focus available resources on carrying out monitoring, experimental, and risk assessments for the chemicals that display the greatest potential to adversely impact Great Lakes ecosystems.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphibian studies to investigate the endocrine disrupting properties of chemicals through the thyroid modality: a comparison of their statistical power.","authors":"Simone Rizzuto, Franco Maria Neri, Valeria Ercolano, Alessio Ippolito, Alberto Linguadoca, Laura Villamar Bouza, Maria Arena","doi":"10.1093/etojnl/vgaf067","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf067","url":null,"abstract":"<p><p>Amphibians are the current model species for investigating the endocrine disrupting (ED) properties through the thyroid modality in non-mammalian species. A recurrent question in the EU regulatory endocrine assessment of pesticide active substances (2018/605) is whether the positive results from an in vivo screening test, ie, Amphibian Metamorphosis Assay (AMA) can be considered sufficient to conclude on the ED properties of a pesticide active substance, or whether the Larval Amphibian Growth and Developmental Assay (LADGA) is a necessary step to further clarify the concerns identified in the AMA. Another one is the consideration of the Extended AMA (EAMA). To further clarify some of the uncertainties around the use of the LAGDA, and to help further consideration of the EAMA in regulatory context, the statistical power of the three test designs was tested for all the parameters entailed to be measured in the respective study design (except for thyroid histopathology) by using data from real experimental studies. Our findings showed that the statistical power of the EAMA is in line with other OECD standardized tests ie, AMA, LAGDA. Our results also confirmed that the LAGDA is more powerful to detect effects on relevant parameters, ie, time to reach metamorphosis, compared to other in vivo tests. However, the difference in power was small, questioning its contribution to an overall weight of evidence already supporting the identification of a substance as an ED. These findings should be considered only in the context of hazard-based endocrine assessment of active substances (ie, EU regulatory ED assessment of pesticide active substances, 2018/65), while they may not be fully applicable for risk assessment-based approach.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning toxicity profiles of graphene oxide through imidazole-oxime modification: zebrafish as a model system.","authors":"Serkan Yıldırım, Mine Köktürk, Aybek Yiğit, Ayse Sahin, Metin Kılıççıoğlu, Muhammed Atamanalp, Berrah Gözegir, Dilek Nazli, Gunes Ozhan, Nurettin Menges, Gonca Alak","doi":"10.1093/etojnl/vgaf075","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf075","url":null,"abstract":"<p><p>The increasing use of nanotechnology, especially in agriculture and the food industry, has raised concerns about the possible adverse effects of nanomaterials (NMs) on human health and the environment. This study investigates the effects of synthesized graphene oxide (GO) and its derivatives on zebrafish exposed for 96 hours, focusing on morphological changes in brain tissue, histopathology and immunofluorescent markers such as 8-hydroxy-2'-deoxyguanosine (8-OHdG) and nucleolar protein 10 (NOP10). Exposure to GO resulted in malformations, DNA damage and increased NOP10 expression, and reduced hatching and survival rates. Our results demonstrated that exposure to GO, GO-OX and OX exerted dose-dependent inhibitory effects on hatching and promoted malformations in zebrafish larvae. Histopathological analysis revealed that higher doses led to more pronounced tissue damage, with GO 50 causing severe degeneration and necrosis, while high doses of GO-OX and OX resulted in moderate tissue changes. This was further supported by the increased expression levels of 8-OHdG (marker of oxidative DNA damage) and NOP10 (marker of nucleolar stress), which aligns with the histopathological findings and confirms the neurotoxic effects. Notably, GO-OX treatments consistently mitigated both morphological and neurotoxic effects at all doses, suggesting that oxime functionalization reduces the inherent toxicity of GO. In contrast, treatment with different concentrations of GO-OX (graphene oxide- oxime) derivatives mitigated these adverse effects, reducing them to mild or moderate levels.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Xenopus Eleutheroembryo Thyroid Assay (XETA), a New Approach Methodology (NAM) for the regulatory assessment of thyroid activity of chemicals.","authors":"David Du Pasquier, Andrew Tindall, Lennart Weltje, Laurent Lagadic, Gregory Lemkine","doi":"10.1093/etojnl/vgaf074","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf074","url":null,"abstract":"","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging invasive mussel contaminant survey data for stepwise prioritization of chemicals of potential concern in the Great Lakes basin.","authors":"N Fuller, K Kimbrough, M E Edwards, E M Maloney, S R Corsi, M A Pronschinske, L A DeCicco, J Frisch, A K Baldwin, S L Hummel, N Vinas, D L Villeneuve","doi":"10.1093/etojnl/vgaf072","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf072","url":null,"abstract":"<p><p>Historical and ongoing anthropogenic activities coupled with advancements in analytical techniques have led to the detection of large numbers of contaminants in the Laurentian Great Lakes. Consequently, identifying and prioritizing chemicals likely to cause ecological harm represents a challenge for natural resource managers. Previous prioritization efforts have focused on contaminants in sediment, water, and passive samplers, which may not be representative of compounds that bioaccumulate in aquatic organisms. Consequently, the present study adopted a stepwise method to prioritize chemicals of potential concern detected in dreissenid mussels from samples collected across the Great Lakes from 2009-2018. The stepwise method considered environmental fate, detection frequency and exceedance of toxicity quotients based on ecotoxicological effect concentrations. Overall, a total of 153 compounds out of 267 analyzed were detected in dreissenid mussels, 47 of which had water quality effect concentrations, 56 had apical effect concentrations (Tier 1 ECOTOX or apical screening), 17 had non-apical effect concentrations (Tier 2 ECOTOX, Cytotoxic Burst, and ToxCast) and 33 had estimated effect concentrations (QSAR, estimated screening and pharmacological potency). Of the compounds with water quality effect concentrations, 9 were designated as high priority including the herbicide atrazine and 5 polycyclic aromatic hydrocarbons (PAHs) that were previously identified as potentially hazardous within other matrices. Similar contaminants were identified as high priority in a related study of native unionid mussels in the Great Lakes. A total of 27 compounds were low priority, suggesting that these contaminants do not warrant further action based on this dataset. Overall, these findings will facilitate the development of management strategies to mitigate the effects of contaminants on aquatic organisms within the Great Lakes.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury concentrations in Lake Sturgeon from four river systems in Manitoba, Canada.","authors":"Wolfgang Jansen, James K Aiken","doi":"10.1093/etojnl/vgaf071","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf071","url":null,"abstract":"<p><p>Lake Sturgeon (Acipenser fulvescens) are large, long-lived fish, characteristics conducive to the bioaccumulation of mercury, a harmful contaminant. This study measured total mercury (THg) in the axial musculature of 319 Lake Sturgeon captured between 2002 and 2022 from six river reaches on the Winnipeg, Nelson, Churchill, and Hayes rivers in the province of Manitoba, Canada. Since the 1900s, all sampled rivers except the Hayes were impacted by hydroelectric development, which can increase THg concentrations in fish for several decades following inundation. Concentrations of THg in Lake Sturgeon measuring 171-1,435 mm fork length ranged from less than the detection limit (0.005 ppm) to 0.698 ppm wet weight. THg concentrations increased significantly with fish length for all waterbodies analyzed except for the Hayes River where the sample size and length range were small. Mean length-standardized THg concentrations ranged from 0.069 to 0.177 ppm and differed significantly between waterbodies. Concentrations were lowest where the majority of samples were collected from fish that had been hatchery-reared and stocked. A paucity of historical data precludes the isolation of effects of hydroelectric impoundment on THg levels in Lake Sturgeon, but concentrations are not particularly high in any of the waterbodies examined herein. Of the 35 Lake Sturgeon also analyzed for diet composition, 34 had identifiable gastrointestinal contents. Ten different prey taxa were identified, including fish. Chironomids dominated dietary numerical abundance. The number of taxa increased with fish length to include larger, and therefore potentially more THg-rich organisms.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review on the environmental remediation of pharmaceuticals in water by adsorption.","authors":"Zumra Zumra, Saeed Ahmed","doi":"10.1093/etojnl/vgaf065","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf065","url":null,"abstract":"<p><p>Pharmaceuticals in polluted water can harm humans, animals, and marine life. Pharmaceuticals undergo degradation and give secondary products that are more toxic, so their infiltration becomes life-threatening and life-saving if not properly disposed of. Among various processes such as membrane filtration, advanced oxidation processes, biodegradation, etc, adsorption is considered the most appropriate for efficiently removing pharmaceuticals from water. This review summarises different adsorbents and recent advances to enhance the adsorption capacity of the adsorbents, including carbon-based material, zeolites, metal-organic frameworks, and polymers. Every adsorbent is evaluated based on different parameters like removal capacity, removal efficiency, pH, temperature, and mechanism of action. The parameters like pH range and temperature depend on the adsorbent-adsorbate system and the experimental conditions. There was a wide variation in removal efficiencies: 28%-99.7% for carbon-based adsorbents, 37% - 100% for zeolites, 86%-99.3% for metal-organic frameworks, and 70-98.2% for polymers. The possible interactions between pharmaceuticals and adsorbents are included for further improvements to increase the adsorption. The outcome of this study highlighted the use of adsorbents and demonstrated how their modification can improve the adsorption of pharmaceuticals from water bodies.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of in vivo fish and amphibian endocrine test guideline assays: current status and future needs.","authors":"Natalie Burden, Constance A Mitchell, Zhichao Dang, Michelle R Embry, Scott Glaberman, Laurent Lagadic, Scott G Lynn, Joseph Marini, Ellen Mihaich, Elena McDermott, Julie Krzykwa, Edward R Salinas, Heiko Schoenfuss, Karen Thorpe, Lennart Weltje, James R Wheeler","doi":"10.1093/etojnl/vgaf064","DOIUrl":"https://doi.org/10.1093/etojnl/vgaf064","url":null,"abstract":"<p><p>Endocrine pathways are crucial in regulating physiological functions in organisms, including growth and development, metabolism, tissue function, and reproduction. Exposure to endocrine disrupting chemicals (EDCs) can interfere with normal hormonal function and lead to adverse effects in organisms and/or their offspring. As a result, regulatory testing and assessment requirements have been implemented to identify and regulate EDCs-defined by the World Health Organization as chemicals that alter the function of an endocrine system and cause \"subsequent adverse effects in an intact organism, its progeny, or (sub)populations\" - although the approaches taken for assessment vary worldwide. As such, the current typical ecotoxicological assessment paradigm for EDCs involves initial testing for endocrine activity using in vitro and lower-tier in vivo assays, followed by higher-tier in vivo testing which can provide additional endocrine mechanistic data and establishes any consequent adversity. The Organisation for Economic Cooperation and Development and the United States Environmental Protection Agency, among other entities, have validated and adopted standardized in vivo test guidelines for mammals, fish, and amphibians. These tests can be challenging and take months to perform, and many require the use of large numbers of laboratory animals. This paper summarizes the current state of the science for evaluating the endocrine disrupting potential of chemicals in fish and amphibians using in vivo test guideline assays across the estrogen, androgen, thyroid, and steroidogenesis modalities. Current challenges associated with conducting and interpreting the in vivo assays are discussed. Opportunities and potential next steps to strengthen this growing area of testing are explored, including potential to inform development and application of new approach methodologies and thereby reduce reliance on using laboratory animals.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}