Studying ototoxicity in zebrafish.

IF 2.8 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology and Chemistry Pub Date : 2025-10-01 DOI:10.1093/etojnl/vgaf161

Eduarda Oliveira Cunha, Dora de Athayde Saul, Murilo Sander de Abreu, Márcia Salgado Machado, Eliane Dallegrave

引用次数: 0

Abstract

Ototoxicity is the adverse reaction in the auditory system caused by exposure to xenobiotics. Animal models have been used to improve the understanding of ototoxicity research. Zebrafish (Danio rerio) is a model animal that is being increasingly used in ototoxicity research. Here, we identified and map the evidence on the use of zebrafish as an animal model to study ototoxicity. We conducted an exploratory systematic search in the three databases (Cochrane, LILACS, and PubMed) with a two-step screening process based on inclusion/exclusion criteria. Outcome measures of included nondrug xenobiotics studies (n = 15) and drugs (n = 118) were grouped into hair cell death rate, exposure time, and developmental stages. Our review indicates zebrafish to be an important model to screen the ototoxicity potential of xenobiotics but also demonstrates that novel studies are necessary to define the most appropriate evaluation outcomes and specific protocol.

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斑马鱼耳毒性研究。

耳毒性是由于接触外源性药物引起的听觉系统的不良反应。动物模型已被用于提高耳毒性研究的认识。斑马鱼（Danio rerio）是一种模型动物，越来越多地用于耳毒性研究。在这里，我们确定并绘制了使用斑马鱼作为动物模型来研究耳毒性的证据。我们在三个数据库（Cochrane、LILACS和PubMed）中进行了探索性系统搜索，并根据纳入/排除标准进行了两步筛选。纳入的非药物异种生物制剂研究（n = 15）和药物研究（n = 118）的结果测量分为：毛细胞死亡率、暴露时间和发育阶段。我们的综述证明了斑马鱼是筛选外源药物耳毒性潜力的重要模型，但也表明需要新的研究来确定最合适的评估结果和具体的方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Toxicology and Chemistry 环境科学-毒理学

CiteScore

7.40

自引率

9.80%

发文量

265

审稿时长

3.4 months

期刊介绍： The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...] Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.