{"title":"RETRACTION: Erianin Suppressed Lung Cancer Stemness and Chemotherapeutic Sensitivity via Triggering Ferroptosis","authors":"","doi":"10.1002/tox.24490","DOIUrl":"10.1002/tox.24490","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> J. Lv, Z. Wang, and H. Liu, “Erianin Suppressed Lung Cancer Stemness and Chemotherapeutic Sensitivity via Triggering Ferroptosis,” <i>Environmental Toxicology</i> 39, no. 2 (2024): 479-486, https://doi.org/10.1002/tox.23832.</p><p>The above article, published online on 20 May 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 4","pages":"715"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Zinc Finger Protein207 Orchestrates Glioma Migration Through Regulation of Epithelial-Mesenchymal Transition","authors":"","doi":"10.1002/tox.24496","DOIUrl":"10.1002/tox.24496","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> C. Zhao, Y. Guo, Y. Chen, G. Shang, D. Song, J. Wang, J. Yang, and H. Zhang, “Zinc Finger Protein207 Orchestrates Glioma Migration Through Regulation of Epithelial-Mesenchymal Transition,” <i>Environmental Toxicology</i> 40, no. 5 (2025): E29–E43: https://doi.org/10.1002/tox.24271.</p><p>The above article, published online on 9 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 5","pages":"862"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: USP14 Promotes the Proliferation of Cervical Cancer via Upregulating β-Catenin","authors":"","doi":"10.1002/tox.24493","DOIUrl":"10.1002/tox.24493","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> H. Song, J. Qiu, and K. Hua, “USP14 Promotes the Proliferation of Cervical Cancer via Upregulating β-Catenin,” <i>Environmental Toxicology</i> 39, no. 2 (2024): 1031-1043, https://doi.org/10.1002/tox.23990.</p><p>The above article, published online on 9 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"949"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: MiR-375 Impairs Breast Cancer Cell Stemness by Targeting the KLF5/G6PD Signaling Axis","authors":"","doi":"10.1002/tox.24494","DOIUrl":"10.1002/tox.24494","url":null,"abstract":"<p><b>RETRACTON:</b> H. Chen, S. Hou, H. Zhang, B. Zhou, H. Xi, X. Li, Z. Lufeng, and Q. Guo, “MiR-375 Impairs Breast Cancer Cell Stemness by Targeting the KLF5/G6PD Signaling Axis,” <i>Environmental Toxicology</i> 40, no. 5 (2025): E1–E13: https://doi.org/10.1002/tox.24204.</p><p>The above article, published online on 12 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors Haitao Chen, Qianqian Guo, and Lufeng Zheng disagree with this decision. Qianqian Guo, Haitao Chen, and Zheng Lufeng disagree with this decision.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 5","pages":"860"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Development of Gene Panel for Predicting Recurrence in Early-Stage Cervical Cancer Patients","authors":"","doi":"10.1002/tox.24495","DOIUrl":"10.1002/tox.24495","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> Y. Ma and W. Zhu, “Development of Gene Panel for Predicting Recurrence in Early-Stage Cervical Cancer Patients,” <i>Environmental Toxicology</i> 40, no. 5 (2025): E14–E28: https://doi.org/10.1002/tox.24270.</p><p>The above article, published online on 2 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. Weipei Zhu disagrees with this decision.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 5","pages":"861"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Li, Keyuan Zhong, Sijie Zhang, Shiyi Duan, Kaijie Huang, Xiaofang Che, Xinchun Guo, Huiqiang Lu
{"title":"Effects of D-Tetramethrin on Zebrafish Development and Immune System","authors":"Yang Li, Keyuan Zhong, Sijie Zhang, Shiyi Duan, Kaijie Huang, Xiaofang Che, Xinchun Guo, Huiqiang Lu","doi":"10.1002/tox.24487","DOIUrl":"10.1002/tox.24487","url":null,"abstract":"<div>\u0000 \u0000 <p>D-tetramethrin is a common insecticide that is important for the control of mosquito-transmitted diseases such as malaria and dengue and, due to its widespread use, it is frequently detected in environmental systems. However, there is currently very little information on the influence of D-tetramethrin on non-target organisms. In this study, zebrafish embryos were exposed to various concentrations of D-tetramethrin (0, 3, 6, and 9 mg/L) from 6 to 72 h past fertilization (hpf) to ascertain the influence of D-tetramethrin on the zebrafish immune system and development. We found that D-tetramethrin exposure led to a significant decrease in heart rate, an increase in the yolk area and tail flick frequency, and a shortening of body length in zebrafish larvae, compared with the control group. The number of macrophages and neutrophils in the experimental group of zebrafish larvae decreased significantly and the oxidative stress levels increased compared with the control group. The malondialdehyde (MDA) content and reactive oxygen species (ROS) content increased significantly, while catalase (CAT) activity increased and superoxide dismutase (SOD) activity decreased in the experimental group. At the same time, apoptosis increased in the zebrafish embryo cells, and the expression of apoptosis-related genes such as <i>p53</i>, <i>Bax</i>, and <i>Bcl-2</i> was abnormal. Moreover, the pro-inflammatory genes <i>IL-8</i>, <i>IFN-γ</i>, <i>IL-6</i>, and <i>TNF-α</i> were up-regulated, while the anti-inflammatory gene, <i>IL-10</i>, was down-regulated. Therefore, D-tetramethrin significantly affects the immune system and oxidative stress levels in zebrafish, inducing cell apoptosis and negatively affecting embryo development. These results provide novel data for the toxicity of D-tetramethrin and the potential adverse effects of environment residues.</p>\u0000 </div>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":"990-1000"},"PeriodicalIF":4.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: CAB39 Modulates Epithelial–Mesenchymal Transition Through NF-κB Signaling Activation, Enhancing Invasion, and Metastasis in Bladder Cancer","authors":"","doi":"10.1002/tox.24498","DOIUrl":"10.1002/tox.24498","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> J. Huang, H. Deng, S. Xiao, Y. Lin, Z. Yu, X. Xu, L. Peng, H. Chao, and T. Zeng, “CAB39 Modulates Epithelial–Mesenchymal Transition Through NF-κB Signaling Activation, Enhancing Invasion, and Metastasis in Bladder Cancer,” <i>Environmental Toxicology</i> 39, no. 10 (2024): 4791-4802, https://doi.org/10.1002/tox.24333.</p><p>The above article, published online on 22 August 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"951"},"PeriodicalIF":4.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: NIK-Mediated Reactivation of SIX2 Enhanced the CSC-like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin–Proteasome System","authors":"","doi":"10.1002/tox.24492","DOIUrl":"10.1002/tox.24492","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> L. Daren, Y. Dan, W. Jinhong, and L. Chao, “NIK-Mediated Reactivation of SIX2 Enhanced the CSC-like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin–Proteasome System,” <i>Environmental Toxicology</i> 39, no. 2 (2024): 583-591, https://doi.org/10.1002/tox.23892.</p><p>The above article, published online on 17 July 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 4","pages":"717"},"PeriodicalIF":4.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Leptin Receptor Gln223Arg and Lys109Arg Polymorphisms May Be Associated With HBV-Related Hepatocellular Carcinoma Risk: A System Review and Meta-Analysis","authors":"","doi":"10.1002/tox.24497","DOIUrl":"10.1002/tox.24497","url":null,"abstract":"<p>\u0000 <b>RETRACTION:</b> X. Dong, M. Zou, C. Li, H. Luo, S. Zhu, and Z. Gong, “Leptin Receptor <i>Gln223Arg</i> and <i>Lys109Arg</i> Polymorphisms May Be Associated with HBV-Related Hepatocellular Carcinoma Risk: A System Review and Meta-Analysis,” <i>Environmental Toxicology</i> 39, no. 10 (2024): 4623-4634, https://doi.org/10.1002/tox.24286.</p><p>The above article, published online on 18 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The author Shaoliang Zhu disagrees with this decision.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"950"},"PeriodicalIF":4.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriella A. Matos, Daniela Nunes-Costa, Daniel V. Pinto, Conceição S. Martins, Janayne L. Silva, Paola Caroline Lacerda Leocadio, Maria Emília Rabelo Andrade, Ramon S. Raposo, Igor Tiago, Susana Alarico, Elandia A. Santos, Valbert Nascimento Cardoso, Flávia A. Santos, Jacqueline I. Alvarez-Leite, Nuno Empadinhas, Reinaldo B. Oriá
{"title":"Methylmercury Chronic Exposure and a High-Fat Diet Induce Gut Microbiome Alterations and Intestinal Barrier Disruption in Mice","authors":"Gabriella A. Matos, Daniela Nunes-Costa, Daniel V. Pinto, Conceição S. Martins, Janayne L. Silva, Paola Caroline Lacerda Leocadio, Maria Emília Rabelo Andrade, Ramon S. Raposo, Igor Tiago, Susana Alarico, Elandia A. Santos, Valbert Nascimento Cardoso, Flávia A. Santos, Jacqueline I. Alvarez-Leite, Nuno Empadinhas, Reinaldo B. Oriá","doi":"10.1002/tox.24469","DOIUrl":"10.1002/tox.24469","url":null,"abstract":"<div>\u0000 \u0000 <p>Methylmercury (MeHg) is markedly toxic to humans. Our study explores whether MeHg and high-fat diet (HFD) can impair the intestinal barrier with microbiota dysbiosis in mice. Weanling mice were fed to HFD or standard diet for 40 days. In the last 20 days of diets, mice received either MeHg (20 mg/L) or drinking water. Proximal small intestine, cecum, and hair samples were collected. Villus length, crypt depth, villus/crypt length, mucin2 and lysozyme-positive cell counts, ZO-1 and occludin gene expression, and intestinal functional permeability were analyzed to assess the intestinal barrier. Blood samples were drawn to assess lipid parameters. Gut microbiome profiling was conducted with DNA from fecal/cecal samples. In addition, we analyzed ZO-1 immunofluorescence in the colon and small intestine. HFD increased MDA, Mucin2, and reduced villus height, crypt depth, villus/crypt length, lysozyme(+)-cell count, and increased intestinal permeability, regardless of MeHg intoxication. MeHg-HFD combination affected the intestinal barrier, decreasing ZO-1, occludin, and Nrf2 transcription, and increased permeability. HFD increased total plasma cholesterol and triglycerides. Only MeHg-HFD reduced microbiome alpha-diversity along with colonic ZO-1 immunolabeling loss compared to non-intoxicated mice fed a control diet. Regardless of diet, the genera <i>Streptococcus</i>, <i>Psychrobacter</i>, <i>Facklamia</i>, and <i>Corynebacterium</i> were severely depleted following MeHg intoxication. Other groups, such as <i>Atopostipes</i> and <i>Jeotgalicoccus</i>, were not altered by MeHg or HFD alone, but were significantly reduced by the combined HFD-MeHg. Synergistic effects of MeHg-HFD on the mucosa-associated microbiota are more pronounced than their individual effects. Our findings suggest that MeHg intoxication does not cause extensive dysbiosis but led to intestinal barrier disruption.</p>\u0000 </div>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":"975-989"},"PeriodicalIF":4.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}