Environmental Toxicology最新文献

{"title":"Environmentally Relevant Concentrations of Commercial Titanium Dioxide Nanoparticles Induce Ferroptosis in HUVECs.","authors":"Fangfang Huang, Yashi Feng, Zi-An Wang, Yunchang Cao, Qiong Yan, Wuxiang Wang, Shaolong Feng","doi":"10.1002/tox.24517","DOIUrl":"https://doi.org/10.1002/tox.24517","url":null,"abstract":"<p><p>Titanium dioxide nanoparticles (TiO₂-NPs) have been ever increasingly exposed to people through all possible routes, while studies focusing on their potential cardiovascular risks are relatively lacking, especially the underlying biological mechanisms that are not yet elucidated. In this study, the ferroptotic effect of TiO₂-NPs (30 nm) at environmentally relevant concentrations (0, 3, 12, and 48 μg/mL) on human umbilical vein endothelial cells (HUVECs) and the potential molecular mechanism were studied with the corresponding biochemical and molecular biology assays. The results showed that TiO₂-NPs at the tested concentrations could reduce HUVEC viability, but ferrostatin-1 might rescue this reduction in cell viability. Also, TiO₂-NPs exposure increased Fe²⁺, reactive oxygen species, and malondialdehyde, but decreased glutathione, mitochondrial membrane potential, and activities of anti-oxidative enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in HUVECs through an integrated signaling pathway. Meanwhile, enhanced p38 protein phosphorylation and keap1 protein and decreased Nrf2 protein phosphorylation with reductions in mRNA expressions of downstream anti-oxidative enzyme genes (catalase, superoxide dismutase, glutathione peroxidase, and phospholipid hydroperoxidase) were identified in the TiO₂-NPs-exposed HUVECs. These indicated that TiO₂-NPs exposure induced ferroptosis in HUVECs via the p38/keap1 inhibiting Nrf2 pathway. EC ferroptosis will be a promising biomarker for assessing the cardiovascular health risks of environmental contaminants.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorpyrifos Induces Apoptosis in Macrophages by Activating Both Intrinsic and Extrinsic Apoptotic Pathways.","authors":"Chen-Yu Chiang, Shin-Wu Liu, Chun-Jung Chen, Wen-Ying Chen","doi":"10.1002/tox.24515","DOIUrl":"https://doi.org/10.1002/tox.24515","url":null,"abstract":"<p><p>Although chlorpyrifos poses considerable risks to the environment and human health, it is still used in many countries. This pesticide has various toxic effects on humans, including neurotoxicity, reproductive toxicity, genotoxicity, and organ damage caused by oxidative stress and DNA damage. However, its specific toxicity to the immune system remains unclear. In this study, we explored the intrinsic and extrinsic apoptotic pathways through which chlorpyrifos induces apoptosis in macrophages. RAW 264.7 macrophages were treated with chlorpyrifos at concentrations of 0, 2, 4, 10, and 20 ppm for 3 h. Cytotoxicity was assessed using a lactate dehydrogenase assay, whereas apoptosis was evaluated through flow cytometry. The levels of cysteinyl aspartate-specific proteinase (caspase)-3, caspase-8, and caspase-9 were measured. The disruption of mitochondrial function and the expression of the death receptors Fas receptor and tumor necrosis factor-alpha receptor were assessed through JC-1 stain reagent. The release of mitochondrial cytochrome c, expression of Bcl2 family proteins, and level of cleaved caspases were analyzed through Western blotting. Chlorpyrifos induced cytotoxicity and apoptosis in a concentration-dependent manner. It activated caspase-3, caspase-8, and caspase-9, as well as disrupted mitochondrial function and Bcl2 family protein balance. Furthermore, chlorpyrifos induced the release of cytochrome c from the mitochondria and upregulated the expression of Fas receptor and tumor necrosis factor-alpha receptor. These findings suggest that chlorpyrifos induces cytotoxicity through caspase-3-dependent apoptosis via the intrinsic pathway (caspase-8 activation, mitochondrial dysfunction, Bcl2 protein imbalance, and cytochrome c release) and the extrinsic pathway (caspase-9 activation and death receptor expression).</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “METTL3-Mediated m6A Modification of Pri-miR-148a-3p Affects Prostate Cancer Progression by Regulating TXNIP”","authors":"","doi":"10.1002/tox.24513","DOIUrl":"10.1002/tox.24513","url":null,"abstract":"<p>G. Li, J. Liu, Y. Wang, et al. “METTL3-Mediated m6A Modification of Pri-miR-148a-3p Affects Prostate Cancer Progression by Regulating TXNIP,” Environmental Toxicology 38, no. 10 (2023): 2377–2390, https://doi.org/10.1002/tox.23874.</p><p>The authors regret an error in the authorship designation in the original publication of the article titled <b>“</b>METTL3-Mediated m6A Modification of pri-miR-148a-3p Affects Prostate Cancer Progression by Regulating TXNIP.<b>”</b> The author contributions were misassigned, and the correct author order is as follows:</p><p>\u0000 <b>Original authorship listing:</b>\u0000 </p><p>Guoqiang Li¹, Junwen Liu², Yinhuai Wang¹, Hanqi Liu², Jianhan Fu¹, Yuanqiao Zhao¹, Yanqing Huang^2*\u0000 </p><p>\u0000 ¹Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, 410000, China</p><p>\u0000 ²Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, 410000, China</p><p>*<b>Corresponding author</b>: Yanqing Huang, Department of Histology and Embryology, Xiangya School of Medicine, Central South University, 172 Tongzipo Road, Changsha, 410000, China</p><p>Email: <span>[email protected]</span>\u0000 </p><p>\u0000 <b>Corrected authorship listing:</b>\u0000 </p><p>Yanqing Huang¹, Junwen Liu¹, Yinhuai Wang², Hanqi Liu¹, Jianhan Fu², Yuanqiao Zhao², Guoqiang Li^2*\u0000 </p><p>\u0000 ¹Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, 410000, China</p><p>\u0000 ²Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, 410000, China</p><p>*<b>Corresponding author</b>: Guoqiang Li, Department of Urology, The Second Xiangya Hospital, Central South University, 139 Renmin road, Changsha, 410 000, China, Changsha, 410 000, China</p><p>Email: <span>[email protected]</span>\u0000 </p><p>All authors have agreed to this correction, and we apologize for any inconvenience this may have caused.</p><p>The correction does not affect the scientific validity or conclusions of the original paper.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"948"},"PeriodicalIF":4.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Choline Alleviated Perinatal Fluoride Exposure-Induced Learning and Memory Impairment Through α4β2 nAChRs and α7nAChRs in Offspring Mice”","authors":"","doi":"10.1002/tox.24488","DOIUrl":"10.1002/tox.24488","url":null,"abstract":"<p>Y. Zhao, X. Zhao, and J. Wang, “Choline Alleviated Perinatal Fluoride Exposure-Induced Learning and Memory Impairment Through α4β2 nAChRs and α7nAChRs in Offspring Mice,” <i>Environmental Toxicology</i> 38, no. 3 (2023): 511–521.</p><p>\u0000 <b>Modification:</b>\u0000 </p><p>The immunohistochemistry results of α4β2 nAChRs in the hippocampus and cerebral cortical of the HC+NaF group were replaced with the correct images.</p><p>We apologize for this error.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"946-947"},"PeriodicalIF":4.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Causal Relationship Between 731 Immunocyte Phenotypes and Asthma Risk: A Bidirectional Mendelian Randomization Analysis","authors":"Jie Lin, Zhan Zhang, Qiang Zhou, Jiayi Shi, Wanqing Li, Sen Lin, Hu Tang, Zheyu Zhang, Tianfeng Chen, Xiaojun Cai, Longhe Cao","doi":"10.1002/tox.24506","DOIUrl":"https://doi.org/10.1002/tox.24506","url":null,"abstract":"Growing evidence suggests an association between various immune cell phenotypes and the development of asthma. However, it is still not entirely clear whether specific immune cell phenotypes might causally contribute to the risk of asthma. Despite further studies required to validate this claim, our study delves deeper into explaining this relationship and paving the way toward new therapeutic approaches. Our initial aim is to reveal the causal relationship between 731 immunocyte phenotypes and asthma; a bidirectional Mendelian randomization (MR) analysis was performed. We have investigated 731 immunocyte phenotypes in asthma, using a summary of previously published GWAS. Conducting an MR analysis, we have interpreted the potential causative relationship between them. Our analytical approaches included inverse variance‐weighted average, weighted median (WM) modeling, and pattern‐based approaches. To ensure the robustness and accuracy of our findings, we conducted sensitivity analyses employing MR‐PRESSO, Cochran's <jats:italic>Q</jats:italic> test, leave‐one‐out, and MR‐Egger approaches. Additionally, we conducted a reverse MR analysis to examine potential reverse causality. Our study revealed 43 immunophenotypes with a causal connection to asthma risk. Following Bonferroni correction and sensitivity analysis, we have identified four immunophenotypes with strong causal associations and reliability, them being: HLA DR on DC (95% CI: 1.0008–1.0014, <jats:italic>p</jats:italic> = 4.26 × 10<jats:sup>−6</jats:sup>, FDR = 2.21 × 10<jats:sup>−8</jats:sup>), CD8 on CD28− CD8br (95% CI: 1.0007–1.0020, <jats:italic>p</jats:italic> = 4.01 × 10<jats:sup>−5</jats:sup>，FDR = 5.70 × 10<jats:sup>−4</jats:sup>), CD62L on monocyte (95% CI: 0.9985–0.9995，<jats:italic>p</jats:italic> = 1.06 × 10<jats:sup>−4</jats:sup>，FDR = 9.20 × 10<jats:sup>−4</jats:sup>), CD8br% leukocyte (95% CI: 1.0006–1.0019，<jats:italic>p</jats:italic> = 1.07 × 10<jats:sup>−4</jats:sup>，FDR = 1.14 × 10<jats:sup>−3</jats:sup>). We have confirmed the large co‐inheritance of all these immunophenotypes, which suggests a contribution to asthma development. In addition, reverse MR confirmed that asthma and immune cell phenotypes lack a causal association between them. Our study provides evidence of different immune phenotypes, which are either beneficial or detrimental to asthma. Given the fact that asthma is a broad disease and contains complex immune mechanisms, this research may offer improved outcomes and long‐term asthma treatment strategies.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"4 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Transcriptional Factor BRD4 Promotes the Stemness of Esophageal Cancer by Activating the Nuclear PD-L1/RelB Axis","authors":"","doi":"10.1002/tox.24508","DOIUrl":"10.1002/tox.24508","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>S. Li</span>, <span>Q. Guo</span>, <span>R. Guo</span>, and <span>H. Xu</span>, “ <span>Transcriptional Factor BRD4 Promotes the Stemness of Esophageal Cancer by Activating the Nuclear PD-L1/RelB Axis</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>2</span> (<span>2024</span>): <span>669</span>–<span>679</span>, https://doi.org/10.1002/tox.23939.\u0000 </p><p>The above article, published online on 24 August 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"952"},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Pathogenomics Model for Personalized Medicine in Cervical Cancer: Cross-Talk of Gene Expressions and Pathological Images Related to Oxidative Stress","authors":"","doi":"10.1002/tox.24510","DOIUrl":"10.1002/tox.24510","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>J. Li</span>, <span>S. Chen</span>, <span>J. Wu</span>, <span>X. Liu</span>, <span>H. Liu</span>, <span>Y. Liu</span>, and <span>Z. Zhu</span>, “ <span>Pathogenomics Model for Personalized Medicine in Cervical Cancer: Cross-Talk of Gene Expressions and Pathological Images Related to Oxidative Stress</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>2</span> (<span>2024</span>): <span>751</span>–<span>767</span>, https://doi.org/10.1002/tox.23974.\u0000 </p><p>The above article, published online on 26 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"954"},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Comprehensive Analysis of m6A Modification Patterns and m6A-Related lncRNAs as Potential Biomarkers in Lung Adenocarcinoma","authors":"","doi":"10.1002/tox.24512","DOIUrl":"10.1002/tox.24512","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION:</b> <span>S. Wang</span>, <span>X. Gu</span>, <span>D. Xu</span>, <span>B. Liu</span>, <span>K. Qin</span>, and <span>X. Yuan</span>, “ <span>Comprehensive Analysis of m6A Modification Patterns and m6A-Related lncRNAs as Potential Biomarkers in Lung Adenocarcinoma</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>4</span> (<span>2024</span>): <span>2285</span>–<span>2303</span>, https://doi.org/10.1002/tox.24110.\u0000 </p><p>The above article, published online on 26 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. Sheng Wang disagrees with this decision. Xuyu Gu was unaware that they were included as an author on this submission and was not involved with its creation.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"956"},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24512","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: SIK2-Positive Tumor Epithelial Cells in Breast Cancer Maybe Potential Anti-Cancer Messengers: A Systematic Analysis from a Single-Cell Perspective","authors":"","doi":"10.1002/tox.24511","DOIUrl":"10.1002/tox.24511","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>Q. Wu</span>, <span>C. Qu</span>, <span>L. Xin</span>, <span>F. Yang</span>, and <span>L. Xu</span>, “ <span>SIK2-Positive Tumor Epithelial Cells in Breast Cancer Maybe Potential Anti-Cancer Messengers: A Systematic Analysis from a Single-Cell Perspective</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>2</span> (<span>2024</span>): <span>768</span>–<span>782</span>, https://doi.org/10.1002/tox.23987.\u0000 </p><p>The above article, published online on 29 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"955"},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: An Innovative Predictive Model for Cervical Cancer Constructed Around a Gene Profile Associated With Cholesterol Metabolism","authors":"","doi":"10.1002/tox.24509","DOIUrl":"10.1002/tox.24509","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>T. Pu</span>, <span>Y. Jin</span>, <span>C. Tang</span>, <span>J. Fu</span>, <span>C. Zhang</span>, <span>B. Su</span>, and <span>A. Cao</span>, “ <span>An Innovative Predictive Model for Cervical Cancer Constructed Around a Gene Profile Associated with Cholesterol Metabolism</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>3</span> (<span>2024</span>): <span>1055</span>–<span>1071</span>, https://doi.org/10.1002/tox.23969.\u0000 </p><p>The above article, published online on 11 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 6","pages":"953"},"PeriodicalIF":4.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}