Environmental Toxicology最新文献_第5页

RETRACTION: Pachymic Acid Activates TP53INP2/TRAF6/Caspase-8 Pathway to Promote Apoptosis in Renal Cell Carcinoma Cells 重皮酸激活TP53INP2/TRAF6/Caspase‐8通路促进肾癌细胞凋亡

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-13 DOI: 10.1002/tox.24539

引用次数: 0

RETRACTION: Identification of Potential Therapeutic Targets for Breast Cancer Using Mendelian Randomization Analysis and Drug Target Prediction 撤回：利用孟德尔随机化分析和药物靶点预测确定乳腺癌的潜在治疗靶点

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-13 DOI: 10.1002/tox.24540

引用次数: 0

RETRACTION: Single-Cell Transcriptome Sequencing Analysis Reveals Intra-Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma 撤回：单细胞转录组测序分析揭示了食管鳞状细胞癌的肿瘤内异质性。

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-13 DOI: 10.1002/tox.24542

{"title":"RETRACTION: Single-Cell Transcriptome Sequencing Analysis Reveals Intra-Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma","authors":"","doi":"10.1002/tox.24542","DOIUrl":"10.1002/tox.24542","url":null,"abstract":"\u0000 \u0000 RETRACTION: Y. Nie, G. Yao, Y. Wei, S. Wu, W. Zhang, X. Xu, G. Li, F. Zhou, and Z. Yang, “ Single-Cell Transcriptome Sequencing Analysis Reveals Intra-Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24243.\u0000 The above article, published online on 4 April 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised submission and peer review process. In addition, the authors did not respond to requests to that they verify the origin of the tumor samples and cell lines used in the analysis. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of Netosis by 2,2,4,4-Tetrabromodiphenyl Ether (BDE-47) in Cyprinus Carpio 2,2,4,4-四溴联苯醚（BDE-47）诱导鲤鱼净吸。

IF 3.2 3区医学

Environmental Toxicology Pub Date : 2025-05-12 DOI: 10.1002/tox.24529

Zihan Gao, Junchen Yu, Yizhao Huang, Yang Jiang, Jingzeng Cai, Ziwei Zhang

{"title":"Induction of Netosis by 2,2,4,4-Tetrabromodiphenyl Ether (BDE-47) in Cyprinus Carpio","authors":"Zihan Gao, Junchen Yu, Yizhao Huang, Yang Jiang, Jingzeng Cai, Ziwei Zhang","doi":"10.1002/tox.24529","DOIUrl":"10.1002/tox.24529","url":null,"abstract":"<div>\u0000 \u0000 Polybrominated diphenyl ethers (PBDEs), extensively utilized as brominated flame retardants, have attained pervasive application in diverse products, thereby manifesting as omnipresent contaminants in the global environmental landscape. Among the PBDEs, 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) exhibits the broadest distribution and is recognized for its adverse impact on fish. The formation of neutrophil extracellular traps (NETs) known as “NETosis” is a neutrophil antimicrobial mechanism that plays an important role in the immune system. However, the impact of BDE-47 on the aquatic animal immune system remains unknown. Therefore, our research investigated the toxic mechanism of BDE-47 to fish neutrophils. Firstly, the quantitative analysis of NETs showed that BDE-47 induced the synthesis of NETs. Furthermore, our findings demonstrated that BDE-47 could enhance reactive oxygen species (ROS) levels. The results also suggested that BDE-47 may play a role in promoting neutrophil autophagy and apoptosis. In addition, BDE-47 exposure inhibited the activities of oxidative stress-related antioxidant enzymes and increased malondialdehyde levels, thus causing oxidative stress. Finally, BDE-47 phosphorylated P38 and extracellular signal-regulated Kinase (ERK) pathway proteins. Collectively, BDE-47 promotes NETs formation by facilitating the ROS/P38/ERK axis and oxidative stress in carp neutrophils, promoting cellular autophagy, in addition to activating the mitochondrial apoptotic pathway, and this toxicity exists in a dose-dependent manner. The study investigated the fundamental mechanisms of BDE-47 on carp neutrophils. This investigation offered fresh perspectives on the immunotoxicological mechanisms of BDE-47 and provided a new basis for mitigating the adverse effects of BDE-47 on aquatic animals.\u0000 </div>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 10","pages":"1233-1244"},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: RSPO2-Associated Mitochondrial Metabolism Defines Molecular Subtypes with Distinct Clinical and Immune Features in Esophageal Cancer 撤回：RSPO2相关线粒体代谢定义食管癌中具有不同临床和免疫特征的分子亚型

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24534

引用次数: 0

RETRACTION: Research on the Toxicological Prognostic Significance of Age-Related Genes in Endometrial Cancer Unveiling Key Factors in Patient Prognosis 摘要：年龄相关基因对子宫内膜癌毒理学预后意义的研究揭示了影响患者预后的关键因素

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24535

引用次数: 0

RETRACTION: Prediction of Potential Targets and Toxicological Insights of Astragalus in Liver Cancer Based on Network Pharmacology: Integrating Systems Biology, Drug Interaction Networks, and Toxicological Perspectives 基于网络药理学的黄芪治疗肝癌的潜在靶点预测和毒理学见解：整合系统生物学、药物相互作用网络和毒理学观点

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24533

引用次数: 0

RETRACTION: Characterization of m6A RNA Methylation Mediated Immune Heterogeneity and Functional Validation in Hepatocellular Carcinoma 撤回：肝细胞癌中m6A RNA甲基化介导的免疫异质性的表征和功能验证

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24532

引用次数: 0

RETRACTION: Protective Effect of Hibifolin on Lipopolysaccharide-Induced Acute Lung Injury Through Akt Phosphorylation and NFκB Pathway 撤回：Hibifolin通过Akt磷酸化和NFκB通路对脂多糖诱导的急性肺损伤的保护作用

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24537

{"title":"RETRACTION: Protective Effect of Hibifolin on Lipopolysaccharide-Induced Acute Lung Injury Through Akt Phosphorylation and NFκB Pathway","authors":"","doi":"10.1002/tox.24537","DOIUrl":"10.1002/tox.24537","url":null,"abstract":"\u0000 \u0000 RETRACTION: Y.-Y. Ng, Y.-C. Ho, C.-H. Yen, S.-S. Lee, C.-C. Tseng, S.-W. Wu and Y.-H. Kuan, “ Protective Effect of Hibifolin on Lipopolysaccharide-Induced Acute Lung Injury Through Akt Phosphorylation and NFκB Pathway,” Environmental Toxicology 40, no. 4 (2025): 524–531, https://doi.org/10.1002/tox.24383.\u0000 The above article, published online on 9 August 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. The retraction has been agreed after the authors performed a re-evaluation of the statistical analysis. This corrected analysis revealed that critical results, such as the effects on adhesion molecule expression, IκB degradation, and Akt phosphorylation, no longer achieved statistical significance. These findings directly impact the reliability of the core conclusions of the paper. Furthermore, after publication, the journal identified insufficiencies during the peer review process. Therefore, the article must be retracted.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 8","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Deciphering the Prognostic Landscape of Osteosarcoma: Integrating the Roles of Hippo Pathway Genes, Programmed Cell Death, and the Tumor Immune Microenvironment 撤回：解读骨肉瘤的预后前景：整合Hippo通路基因、程序性细胞死亡和肿瘤免疫微环境的作用

IF 4.4 3区医学

Environmental Toxicology Pub Date : 2025-05-10 DOI: 10.1002/tox.24536

引用次数: 0