Samantha Schildroth, Birgit Claus Henn, Sharonda M Lovett, Amelia K Wesselink, Yael I Nillni, Wendy Heiger-Bernays, Quaker E Harmon, Anissa I Vines, Donna D Baird, Lauren A Wise
{"title":"A prospective study of per- and polyfluoroalkyl substances (PFAS), stress, and birth size in a cohort of U.S. Black women.","authors":"Samantha Schildroth, Birgit Claus Henn, Sharonda M Lovett, Amelia K Wesselink, Yael I Nillni, Wendy Heiger-Bernays, Quaker E Harmon, Anissa I Vines, Donna D Baird, Lauren A Wise","doi":"10.1186/s12940-026-01279-7","DOIUrl":"10.1186/s12940-026-01279-7","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sam Louman, Karlijn J van Stralen, Sophie van Vlijmen, Kaj Wage, Emile Hendrix, Leontien van der Aa, Frans B Plötz, Jeroen Hol, Anjali Kooter-Bechan, Gavin Ten Tusscher, Gerard Hoek, Annemie L M Boehmer
{"title":"Seasonal viruses modify short-term air pollution effects on pediatric wheeze and asthma: a time-series study.","authors":"Sam Louman, Karlijn J van Stralen, Sophie van Vlijmen, Kaj Wage, Emile Hendrix, Leontien van der Aa, Frans B Plötz, Jeroen Hol, Anjali Kooter-Bechan, Gavin Ten Tusscher, Gerard Hoek, Annemie L M Boehmer","doi":"10.1186/s12940-026-01274-y","DOIUrl":"10.1186/s12940-026-01274-y","url":null,"abstract":"<p><strong>Background: </strong>Short-term exposure to air pollution is a known trigger for pediatric wheeze-associated disorders (WAD), such as acute asthma and virus-induced wheezing, yet few air pollution studies account for concurrent viral circulation, which may confound or modify the observed associations. This study aims to assess whether viral circulation confounds or modifies the association between daily levels of air pollution and pediatric WAD emergency department (ED) visits.</p><p><strong>Methods: </strong>We conducted a time-series analysis of 12,603 WAD ED visits among children 2-18 years old across eight hospitals in the Netherlands (2016-2023). Quasi-Poisson models estimated associations between same-day nitrogen dioxide (NO₂), fine and coarse particulate matter (PM₂․₅, PM₁₀) and ozone (O₃) and daily WAD ED visits, and adjusted for seasonality, meteorology and pollen. Base models were compared with confounding and interaction models, which included weekly rhinovirus (RV) or respiratory syncytial virus (RSV) positivity ratios as covariates or interaction terms.</p><p><strong>Results: </strong>In the base models, 3-day lag exposure to NO₂ and PM2.5 was associated with an increase in WAD ED visits (NO<sub>2</sub>: ER% 2.9, 95% CI 0.4-5.6; p = 0.025. PM<sub>2.5</sub>: ER% 3.6, 95% CI 0.4 - 6.9; p = 0.026). Associations were similar after adjustment for viral activity. The interaction models revealed attenuated effect estimates for NO<sub>2</sub>, PM<sub>2.5</sub> and PM<sub>10</sub> during relatively high RV activity. O₃ showed a negative association during low RV periods.</p><p><strong>Conclusions: </strong>In this study, circulating RV modifies, rather than confounds, the association between short-term air pollution and pediatric WAD ED visits. Considering viral activity improves the interpretation of pollution-health associations and may explain inconsistencies across studies.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Douglas Myers, Srijana Mainali, Sanzida Afrin, David Kriebel
{"title":"Air pollution and lung cancer: an investigation of county-level residual incidence rates with smoking eliminated.","authors":"Douglas Myers, Srijana Mainali, Sanzida Afrin, David Kriebel","doi":"10.1186/s12940-026-01277-9","DOIUrl":"10.1186/s12940-026-01277-9","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seigi Karasaki, Hari S Iyer, Amanda I Phipps, Trang VoPham
{"title":"Per- and polyfluoroalkyl substances in drinking water and cancer prevalence in the United States.","authors":"Seigi Karasaki, Hari S Iyer, Amanda I Phipps, Trang VoPham","doi":"10.1186/s12940-026-01272-0","DOIUrl":"10.1186/s12940-026-01272-0","url":null,"abstract":"<p><strong>Background: </strong>Research concerning the adverse health effects of per- and polyfluoroalkyl substances (PFAS) continues to grow. With the recent releases of nationwide data on PFAS in drinking water and public drinking water system service boundaries, it is now possible to conduct nationwide geospatial analyses on the relationships between PFAS in drinking water and aspects of health.</p><p><strong>Objective: </strong>To examine associations between PFAS in drinking water and cancer history prevalence in the United States.</p><p><strong>Methods: </strong>We examined cancer history prevalence, at the census tract level, among adults aged ≥ 18 years diagnosed with any cancer in or prior to 2022 using the United States Population Level Analysis and Community EStimates dataset. We obtained data for PFAS in public drinking water from the Fifth Unregulated Contaminant Monitoring Rule (UCMR 5, 2023-ongoing). We used geographic information systems to spatially join water system boundaries (n = 9,733) with census tracts applying population-weighted areal interpolation. We calculated prevalence ratios (PRs) and 95% confidence intervals (CIs) for the associations between PFAS in drinking water and prevalence of cancer history, adjusted for census tract-level sociodemographics, health conditions and behaviors, and environmental factors.</p><p><strong>Results: </strong>This analysis included 76,606 census tracts with an average cancer history prevalence of 7.8%. We observed positive associations of cancer history prevalence with PFAS levels in drinking water for 6:2-FTS, PFBA, PFBS, PFHpA, PFHxA, PFHxS, PFNA, PFOA, PFPeA, and PFPeS (p < 0.01). For example, for 6:2-FTS, the adjusted PR comparing the highest quintile (0.0182-0.663 µg/L, population-weighted) to samples below the minimum reporting level (< 0.005 µg/L) was 1.04 (95% CI 1.02-1.07, p < 0.001). No associations were observed for HFPO-DA and PFOS. Models mutually adjusted for correlated PFAS showed generally similar results.</p><p><strong>Significance: </strong>Higher levels of certain PFAS in drinking water were independently associated with higher cancer history prevalence. Future research should examine the relationships between individual-level cancer outcomes and individual-level exposure to PFAS in drinking water.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exposure to per- and polyfluoroalkyl substances and adult cardiometabolic health: a Canadian Health Measures Survey mixture analysis.","authors":"Janice M Y Hu, Michael M Borghese, Annie St-Amand","doi":"10.1186/s12940-026-01271-1","DOIUrl":"10.1186/s12940-026-01271-1","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of housing instability in the association between ambient temperature and preterm birth.","authors":"Jinah Park, Ho Kim, Hyojung Lee","doi":"10.1186/s12940-026-01268-w","DOIUrl":"10.1186/s12940-026-01268-w","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The assumption of a threshold is false in risk assessments for endocrine disrupting chemicals (EDCs) when endogenous hormones being disrupted are already above any possible threshold: a policy failure by the US FDA.","authors":"Frederick S Vom Saal, Wade V Welshons","doi":"10.1186/s12940-026-01265-z","DOIUrl":"10.1186/s12940-026-01265-z","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":"11"},"PeriodicalIF":5.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protective versus risky: the complex relationship between prenatal fluoride exposure and birth outcomes in a Chinese large-scale population study.","authors":"Liu Yang, Feifei Yan, Xiumiao Peng, Zhonghua Meng, Xingyi Geng, Wei Wei","doi":"10.1186/s12940-026-01267-x","DOIUrl":"10.1186/s12940-026-01267-x","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youran Tan, Zhenjiang Li, Anne L Dunlop, Mengyuan Ren, Howard H Chang, Zhihao Jin, Jeremy A Sarnat, Anke Huels, Stephanie M Eick, Christine C Ekenga, Armistead Russell, Carmen Marsit, Donghai Liang
{"title":"Associations between prenatal exposure to ambient air pollutants and preterm birth in the Atlanta African American maternal-child cohort.","authors":"Youran Tan, Zhenjiang Li, Anne L Dunlop, Mengyuan Ren, Howard H Chang, Zhihao Jin, Jeremy A Sarnat, Anke Huels, Stephanie M Eick, Christine C Ekenga, Armistead Russell, Carmen Marsit, Donghai Liang","doi":"10.1186/s12940-026-01264-0","DOIUrl":"10.1186/s12940-026-01264-0","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":"15"},"PeriodicalIF":5.3,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}