Environmental Health最新文献

{"title":"Occupational heat exposure and chronic kidney disease risk under climate warming: a retrospective cohort study of petrochemical workers with mechanistic insights.","authors":"Minhua Li, Yilin Zhang, Zitong Zhang, Shanshan Du, Rong Xu, Qing Zu, Zihu Lv, Wei Zheng, Weimin Ye, Jianjun Xiang","doi":"10.1186/s12940-026-01305-8","DOIUrl":"10.1186/s12940-026-01305-8","url":null,"abstract":"<p><p>BACKGROUND: The modifying role of climate warming in the association between occupational heat exposure and chronic kidney disease (CKD), and the related biological mechanisms, remains incompletely understood among petrochemical workers. METHODS: We conducted a retrospective cohort study of 2,649 petrochemical workers in southeastern China between 2013 and 2022. Occupational heat exposure was assessed using on-site wet-bulb globe temperature (WBGT) measurements, reflecting the overall workplace thermal load arising from ambient temperature, process-related heat sources, humidity, and air movement. Incident CKD was defined according to the 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Long-term ambient temperature data were incorporated to evaluate effect modification by climate warming and ambient temperature background. In addition, mediation analyses of blood-based biomarkers and a nested case–control metabolomics study were conducted to explore potential biological mechanisms. RESULTS: During a median follow-up of 7.1 years, 386 incident CKD cases were identified. Occupational heat exposure was significantly associated with an increased risk of CKD (HR = 1.40, 95% CI: 1.13–1.71). This association was significantly amplified under conditions of greater climate warming and higher annual mean ambient temperatures (P-interaction < 0.001). Mediation analyses indicated that uric acid, hemoglobin, and albumin partially mediated the association between occupational heat exposure and CKD risk. Metabolomic analyses further revealed shared metabolic alterations related to the accumulation of gut-derived uremic toxins and disturbances in amino acid metabolism. CONCLUSIONS: Occupational heat exposure was associated with an elevated risk of CKD among petrochemical workers, and this risk is likely further intensified in the context of ongoing climate warming. These findings highlight the importance of incorporating climate context into occupational heat-related health risk assessments and suggest that integrating routine biomarkers with metabolomic features may enhance early identification and prevention of CKD among occupational heat-exposed workers. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and mortality in a University of Michigan amyotrophic lateral sclerosis cohort: a survival analysis.","authors":"Meredith Pedde, Sara D Adar, Dae-Gyu Jang, Eva L Feldman, Stephen A Goutman","doi":"10.1186/s12940-026-01295-7","DOIUrl":"10.1186/s12940-026-01295-7","url":null,"abstract":"<p><p>BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rare, fatal, neurodegenerative disease. With limited treatment options, identifying modifiable risk factors that impact ALS survival is an important goal. Air pollution may be one such risk factor, yet the research on this topic is limited. METHODS: We assessed survival for ALS patients at the University of Michigan Pranger ALS Clinic who were recruited to participate in a prospective cohort study between 2009 and 2022. Participants’ personal characteristics were linked with residential air pollutant levels of fine particulate matter mass (PM2.5), nitrogen dioxide (NO2), and ozone (O3), as well as several particle components, including black carbon (BC), nitrate, sulfate, and sea-salt (as a negative control) over follow-up. To assess the role of air pollution on ALS mortality we used time-dependent Cox proportional hazards models with days from diagnosis as the time axis, adjusted for potential confounders and co-pollutants. RESULTS: Across the 1,276 total years of person-time during follow-up (2.7 ± 2.5 years per participant) there were 329 deaths. In fully adjusted multi-pollutant models, one interquartile range (IQR) (2.1 µg/m3) higher 1-year average PM2.5 was associated with a 66% (HR 1.66 per IQR; 95% CI 1.03–2.68) increase in the hazard of death. The other pollutants were not associated with death in participants with ALS . CONCLUSIONS: This finding suggests a seven month longer median survival for a 2.1 µg/m3 decrease in 1-year average PM2.5, which is significant given that ALS lacks a cure and that existing treatments only extend survival by a few months. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and adrenal hormone alteration in Ecuadorian adolescents with home and school proximity to floriculture crop area.","authors":"Georgia L Kayser, Jasen Zhang, Azarakhash Baghdad, Jenny Wei, Briana N C Chronister, Alhelí Calderón-Villarreal, Kimberly C Brouwer, Jose Suarez-Torres, Franklin De La Cruz, Jose R Suarez-Lopez","doi":"10.1186/s12940-026-01291-x","DOIUrl":"10.1186/s12940-026-01291-x","url":null,"abstract":"<p><p>BACKGROUND: Pesticides frequently used in agriculture, including organophosphates, glyphosate, and 2,4-D, have endocrine disrupting potential. We previously found that residential proximity to floriculture crops can increase the potential for pesticide exposure of children and adolescents. Little is known about whether residential or school proximity to crops can affect their hormone levels. METHODS: We examined 507 adolescents (12–17 years, 51% female, ESPINA cohort) living in agricultural communities in Ecuador. Salivary dehydroepiandrosterone (DHEA), testosterone, estradiol, and cortisol were measured. Using linear regression, we analyzed the association of hormones with residential distance to floricultural crops and crop areas near homes and schools within various radii (150 m, 200 m, 300 m, and 500 m). RESULTS: The median (25th-75th percentile) residential proximity to floricultural crops was 312.6 m (112.3, 653.2), and 49% of adolescent participants lived within 300 m. Among these, the median (25th-75th percentile) crop area within 300 m was 8000m2. Within 150 m of children’s homes, doubling crop area was associated with lower concentrations of testosterone in boys (-9.14% (95% CI: -15.08%, -2.79%)). Doubling crop area within 300 m of homes was associated with greater cortisol concentrations in boys (8.05% (95% CI: 0.45%, 16.23%)). Doubling crop area within 500 m of homes was associated with lower estradiol in boys (-4.82% (95% CI: -9.26%, -0.17%)). Doubling crop area within 100 m of children’s schools was associated with lower estradiol in boys (-6.70% (95% CI: -11.78%, -1.34%)). CONCLUSIONS: We found greater crop area near homes was associated with testosterone, estradiol, and cortisol alterations in boys but not girls. Greater crop area near schools was associated with estradiol alterations in boys. This research suggests home and school proximity to pesticide spray site pose a risk to the developing endocrine systems of children. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupation and urinary phthalate metabolite concentrations in a national survey of adults in Canada.","authors":"Patrick Hinton, Ryann E Yeo, Joanne Kim, Daniel R S Middleton, Katherine Pullella, Victoria Arrandale, Nathan L DeBono","doi":"10.1186/s12940-026-01297-5","DOIUrl":"10.1186/s12940-026-01297-5","url":null,"abstract":"<p><p>BACKGROUND: Phthalates are synthetic chemicals with widespread exposure linked to adverse health effects. Occupational determinants remain understudied despite the potential for substantially elevated workplace exposure levels. This study aimed to investigate the associations between occupation and urinary phthalate metabolite concentrations in a national sample of Canadian adults. METHODS: We analyzed data from 4,259 adults, aged 20–79 years, from four cycles (2007–2019) of the cross-sectional Canadian Health Measures Survey, which quantified 11 urinary phthalate metabolites. We compared creatinine-corrected concentrations of individual metabolites and four summary measures of phthalates across occupation (10 broad- and 40 major-level groups) and industry (19 sectors). Multivariable linear regression models estimated geometric mean ratios (GMRs) and 95% confidence intervals (CIs). For four metabolites with low detection frequencies, multivariable logistic regression estimated odds ratios of detection. Models were adjusted for sociodemographic, lifestyle, and dietary confounders. Sensitivity analyses compared results using specific gravity-corrected concentrations. RESULTS: Non-occupational factors, including female sex, Asian and Black ethnicity, and higher fruit and vegetable consumption, were associated with elevated phthalate concentrations. Workers in natural resources, agriculture, and related production had elevated concentrations of most metabolites, including mono(3-carboxypropyl) phthalate (MCPP) (GMR = 1.64, 95% CI: 1.15, 2.33) and monobenzyl phthalate (MBzP) (GMR = 1.41, 95% CI: 0.97, 2.03). Workers in trades, transport, and equipment operation also exhibited modestly increased exposures, particularly trades helpers and construction labourers for mono-n-butyl phthalate (MBP) (GMR = 1.41, 95% CI: 1.05, 1.89) and MCPP (GMR = 1.80, 95% CI: 1.22, 2.67). Elevated concentrations were also observed among workers in service support and other service occupations, with precise increases across several metabolites. Elevated concentrations in construction and industrial trades were largely driven by males, while females were the primary drivers of elevated di(2-ethylhexyl) phthalate (DEHP) metabolites in natural resources and agriculture, and of increases more broadly in service support occupations. CONCLUSION: This study identifies significantly elevated phthalate exposures among Canadian workers in agriculture, construction, and trades, as well as in service support roles. These findings highlight novel at-risk occupational groups beyond traditional manufacturing settings providing critical evidence for targeting exposure reduction and disease prevention strategies. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial variation of asthma rates in Los Angeles County by environmental and socioeconomic indicators.","authors":"Parsa Khawari, Scott M Bartell, Andrew Odegaard, Veronica M Vieira","doi":"10.1186/s12940-026-01298-4","DOIUrl":"10.1186/s12940-026-01298-4","url":null,"abstract":"<p><p>BACKGROUND: Asthma is a chronic lung disease affecting nearly 1.2 million people in Los Angeles (LA) County. Asthma can be triggered and worsened by environmental pollutants. Exposure to oil/gas well operations, environmental contamination, and other forms of environmental degradation have been linked with poorer respiratory outcomes. METHODS: We used Generalized Additive Models (GAMs) with a bivariate smooth of location and Quasipoisson framework to examine the relationship between location and asthma emergency department visitation (EDV) rates for census tracts in LA County (n = 2106). Using CalEnviroScreen scores, we predicted and mapped the rates after adjustment for environmental exposures and socioeconomic factors to determine if observed spatial patterns in asthma EDV could be explained by these known characteristics. Permutation tests were conducted to identify areas of elevated asthma EDV rates. We also calculated rate ratios (RR) and 95% confidence intervals for the indicators. RESULTS: The rate of asthma EDVs was highest to the north of the major shipping ports in the county. Per interquartile range increase, poverty (RR: 1.29 [1.26–1.32]), percent of the population unemployed (RR: 1.02 [1.00–1.03], and solid waste site scores (RR: 1.01 [1.00–1.02]), were associated with higher asthma EDV rates. Poverty contributed the most to the observed spatial variation in asthma EDV. CONCLUSION: These findings can motivate future research to investigate spatial variation in asthma using higher resolution individual-level data, especially in the identified areas of elevated risk in LA County. Solid waste exposure indicators, poverty level, and unemployment explained some of the spatial variation of asthma EDV rates. Closer investigations in these geographic areas can help us better understand the disparities in exposure and risk. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial dysfunction as a potential pathway linking DL-PCB exposure to intrauterine growth retardation.","authors":"Huisheng Yao, Chao Jiang, Hongyan Zhang, Si Si, Xingqiang Li, Yue Zhang","doi":"10.1186/s12940-026-01263-1","DOIUrl":"10.1186/s12940-026-01263-1","url":null,"abstract":"<p><strong>Backgraound: </strong>Dioxin-like polychlorinated biphenyls (DL-PCBs) are persistent organic pollutants with known endocrine-disrupting and developmental toxicity. Increasing evidence suggests that prenatal exposure to DL-PCBs may adversely affect fetal growth; however, few studies have examined congener-specific and mixture-level effects, and the underlying biological mechanisms remain unclear. This study aimed to assess the relationship between umbilical cord DL-PCB concentrations and key fetal growth indicators including birth weight (BW), birth length (BL), and head circumference (HC), and to explore whether mitochondrial dysfunction mediates these effects.</p><p><strong>Methods: </strong>A total of 5421 mother-infant pairs were recruited between 2022 and 2024 from a multicenter birth cohort in China. Twelve WHO-designated DL-PCB congeners were quantified in umbilical cord blood using gas chromatography-mass spectrometry (GC-MS). We employed multivariable linear regression, sex-stratified models, Bayesian kernel machine regression, generalized weighted quantile sum (gWQS), quantile g-computation (g-comp), and mediation analysis to evaluate individual and mixture effects.</p><p><strong>Results: </strong>Eight DL-PCBs, particularly PCB-77 and PCB-126, were significantly associated with reduced BW (ranging from - 26.52 g to - 80.05 g per IQR increase). PCB-77 and PCB-126 were also negatively associated with HC, while no DL-PCBs showed significant associations with BL. Although inverse associations appeared stronger in boys, sex interactions were not statistically significant. Mediation analysis revealed that mitochondrial DNA content partially mediated the relationship between several DL-PCBs (e.g., PCB-77, PCB-81, PCB-118, PCB-126) and BW, with up to 10.76% of the total effect explained. Mixture models confirmed negative associations with BW and HC, with g-comp estimating a 161.95 g BW reduction per cumulative exposure unit. Bayesian kernel machine regression further identified PCB-77 and PCB-126 as dominant contributors.</p><p><strong>Conclusion: </strong>These findings suggest that mitochondrial dysfunction may be a mechanistic pathway linking prenatal DL-PCB exposure to intrauterine growth restriction, especially reduced birth weight, highlighting potential developmental risks from environmental contamination.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of dietary patterns in modifying the association between ambient PM_2.5 exposure and mortality in elderly Hong Kong Chinese.","authors":"Shu-Yi Li, Jason Leung, Zhi-Hui Lu, Kin-Fai Ho, Yi Su, Blanche Yu, Timothy Kwok","doi":"10.1186/s12940-026-01296-6","DOIUrl":"10.1186/s12940-026-01296-6","url":null,"abstract":"<p><p>BACKGROUND: The potential of dietary patterns to modify the associations between long-term ambient fine particulate matter (PM2.5) exposure and all-cause, respiratory, and circulatory mortality remains unclear. METHODS: A total of 3,937 older adults (≥ 65 years) living in the community were enrolled in a prospective cohort study from 2001 to 2003 in Hong Kong. Assessment of the Diet Quality Index-International (DQI-I), Dietary Inflammatory Index (DII), the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was carried out utilizing a 280-item food frequency questionnaire. Annual PM2.5 concentrations were estimated via land use regression models. Mortality outcomes were sourced from official death registry. Time-varying Cox proportional hazards models were applied to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs). RESULTS: During a median of 16.8 years follow-up, 1,856 deaths were recorded. PM2.5 exposure significantly increased the risks of all-cause mortality, respiratory and circulatory mortality. The MIND diet interacted with PM2.5 exposure on all-cause (p-interaction = 0.008) and respiratory mortality (p-interaction = 0.022). Higher MIND diet scores (≥ median) attenuated the adverse PM2.5 exposure-mortality association, showing lower risks for all-cause (HR: 1.18, 95% CI: 1.06–1.32) and respiratory mortality (HR: 1.14, 95% CI: 0.91–1.41). In contrast, those with lower MIND scores (< median) had elevated mortality risks, with HRs of 1.45 (95% CI: 1.27–1.65) for all-cause mortality and 1.60 (95% CI: 1.24–2.06) for respiratory mortality. No significant interaction was observed for circulatory mortality. Besides, no interaction was found between PM2.5 exposure with DQI-I or DII in relation to mortality. CONCLUSIONS: Adherence to MIND diet may mitigate the detrimental effects of long-term exposure to PM2.5 on all-cause and respiratory mortality in older adults, whereas overall diet quality or an anti-inflammatory diet showed no protective effects. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cotinine-assessed tobacco exposure, cadmium co-exposure, and childhood obesity: a cross-sectional study.","authors":"Fanjia Guo, Changming Ding, Simeng Gu, Wanying Shi, Xinhan Zhang, Yingli Qu, Peiwei Xu, Zhe Mo, Xiaofeng Wang, Sujun Yan, Peijie Sun, Feng Zhao, Ying Zhu, Yuebin Lv, Zhijian Chen, Xiaoming Shi, Xiaoming Lou","doi":"10.1186/s12940-026-01262-2","DOIUrl":"10.1186/s12940-026-01262-2","url":null,"abstract":"<p><p>BACKGROUND: The association between tobacco exposure and obesity remains controversial, with the potential modifying role of cadmium (Cd) unclear. Childhood population provide a critical window to assess low-dose tobacco effects. This study aimed to investigate the association between serum cotinine-assessed tobacco exposure and childhood obesity, and further evaluate whether Cd exposure acts as a potential effect modifier in this association. METHODS: This nationwide cross-sectional study investigated 5,595 school-aged children from 2017 to 2018 China National Human Biomonitoring. Serum cotinine levels were measured to assess tobacco exposure. General obesity was determined using BMI Z-score, and central obesity was assessed via waist circumference, waist-to-height ratio, and body roundness index. Weighted regression and restricted cubic splines (RCS) assessed associations between cotinine and obesity, with interaction analyses for Cd exposure. RESULTS: Compared to the lowest cotinine tertile, individuals with the highest tertile had higher odds of general obesity (OR = 1.485; 95% CI: 1.096, 2.011) and central obesity (OR = 1.333; 95% CI: 1.030, 1.723). RCS models indicated linear and positive associations. Cd exposure significantly attenuated the association between cotinine levels and general obesity (Pinteraction = 0.002), with stronger effects observed in low Cd subgroups (OR = 1.279; 95% CI: 1.133, 1.444). CONCLUSIONS: These results indicate positive associations of tobacco exposure with general and central obesity among nonsmoking children, and Cd acted as an effect modifier. This study suggested that environmental tobacco reduction and considering Cd co-exposure could have implications for obesity in children and adolescents. </p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of anti-inflammatory pathways by polyunsaturated fatty acid signaling may protect neurodevelopment in children prenatally exposed to methylmercury.","authors":"Clara Bartra, Sabrina Llop, Julia Kuligowski, Abel Albiach-Delgado, Cristina Suñol, Eduard Rodríguez-Farré, Ferran Ballester, Raquel Soler-Blasco, Beatrice Jora, Júlia Jarné-Ferrer, Christian Griñán-Ferré, Santiago Vázquez, Mercè Pallàs, Coral Sanfeliu","doi":"10.1186/s12940-026-01270-2","DOIUrl":"10.1186/s12940-026-01270-2","url":null,"abstract":"","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"25 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of clinicians engaged in report-back of individual chemical exposures in two pregnancy cohorts.","authors":"Alina M McIntyre, Katherine Franz, Cecilia Powderly, Nobel Hernández Otero, Katherine E Boronow, Julia Green Brody, Phil Brown, Carmen Milagros Vélez Vega, Tamarra James-Todd, Marlee R Quinn, Jennifer Liss Ohayon","doi":"10.1186/s12940-026-01293-9","DOIUrl":"10.1186/s12940-026-01293-9","url":null,"abstract":"<p><p>Reporting individualized chemical exposure results increases environmental health literacy, empowers study participants to reduce harmful exposures, and supports researchers in identifying and addressing exposure sources. Despite recommendations to increase clinicians’ roles in environmental health promotion, clinician-involvement in environmental health report-back remains limited. This study investigates clinician-facilitated environmental health report-back as a promising approach to results dissemination. We partnered with two pregnancy cohort studies to implement report-back of individual chemical results delivered by clinicians. Nine clinicians provided individualized exposure results to 87 participants across the two cohort studies. Following report-back sessions, we conducted semi-structured interviews to assess clinician experiences, perceived facilitators and barriers to report-back, and shifts in environmental health knowledge. Clinician-facilitated report-back was described as a rewarding process that enhanced clinicians’ ability to not only guide study participants through their individual chemical results but also expand their ability to provide environmental health information to other patients. Clinicians reported increased environmental health knowledge and adoption of personal exposure reduction habits. Clinicians from both cohorts discussed the challenge of communicating scientific uncertainty surrounding specific chemical exposures and related health outcomes. To address this, clinicians relied on structured training and materials developed by the study team to provide practical and actionable exposure reduction recommendations. Expanding training opportunities, embedding environmental health information into medical curricula and clinical practice, and developing guidance for clinician participation could advance communication of environmental exposure results.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}