EFSA Journal最新文献

{"title":"Assessment of the feed additive consisting of Enterococcus lactis DSM 7134 (Bonvital®) for sows for the renewal of its authorisation (Lactosan GmbH & Co.KG)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Pier Sandro Cocconcelli,&nbsp;Montserrat Anguita,&nbsp;Jaume Galobart,&nbsp;Matteo L. Innocenti,&nbsp;Rosella Brozzi","doi":"10.2903/j.efsa.2025.9353","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9353","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of the authorisation of Bonvital® as a zootechnical additive for sows. Bonvital® is currently authorised for use in weaned piglets, pigs for fattening, sows, chickens for fattening, laying hens, chickens reared for laying and minor poultry species (other than those used for laying). The active agent of Bonvital® was originally identified as <i>Enterococcus faecium</i>. In a previous opinion the strain was reassigned to <i>Enterococcus lactis</i>. The applicant provided evidence that the additive currently on the market complies with the existing terms of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concluded that the additive remains safe for the target species, consumers and the environment under the authorised conditions of use. Bonvital® in its powder form is not irritant to the skin and eyes but no conclusion is possible for the granulated form. Bonvital® should be considered a skin and respiratory sensitiser and any exposure through skin and respiratory tract is considered a risk. There is no need to assess the efficacy of Bonvital® in the context of the renewal of the authorisation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a feed additive consisting of Bacillus subtilis DSM 32324, Bacillus subtilis DSM 32325 and Bacillus amyloliquefaciens DSM 25840 (GalliPro® Fit & GalliPro® Fit 10) for all poultry (Chr. Hansen A/S)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Paul Brantom,&nbsp;Lieve Herman,&nbsp;Montserrat Anguita,&nbsp;Jaume Galobart,&nbsp;Matteo L. Innocenti,&nbsp;Jordi Ortuño,&nbsp;Rosella Brozzi","doi":"10.2903/j.efsa.2025.9361","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9361","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of <i>Bacillus subtilis</i> DSM 32324, <i>B. subtilis</i> DSM 32325 and <i>Bacillus amyloliquefaciens</i> DSM 25840 (GalliPro® Fit 10) as a zootechnical feed additive for all poultry species. The additive in a less concentrated form (GalliPro® Fit) is already authorised for use in feed and water for drinking for poultry for fattening, reared for laying or reared for breeding. With the current application, the applicant is seeking the authorisation for use in feed and water for drinking for all poultry. In addition, the applicant is seeking the modification of the terms of the existing authorisation by introducing a new formulation with a 10-fold increased concentration of the active agents in the additive (from 3.2 × 10⁹ to 3.2 × 10¹⁰ colony forming units (CFU)/g additive). The FEEDAP Panel concluded that the additive is considered safe for the target species, including poultry species for laying and breeding, consumers and the environment at the proposed conditions of use. Both forms of the additive are non-irritant to the eyes but are considered skin and respiratory sensitisers, and any exposure through skin and respiratory tract is considered a risk. The additive has the potential to be efficacious as a zootechnical additive in all poultry at 1.6 × 10⁹ CFU/kg feed and 5.4 × 10⁸ CFU/L water for drinking.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the feed additive consisting of Saccharomyces cerevisiae NCYC R404 for dairy cows for the renewal of its authorisation (Volac International Ltd)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Andrey Yurkov,&nbsp;Montserrat Anguita,&nbsp;Nicole Bozzi Cionci,&nbsp;Rosella Brozzi,&nbsp;Yolanda García-Cazorla,&nbsp;Jordi Tarrés-Call,&nbsp;Piera Valeri,&nbsp;Matteo L. Innocenti","doi":"10.2903/j.efsa.2025.9342","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9342","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of the authorisation of <i>Saccharomyces cerevisiae</i> NCYC R404 as a zootechnical additive (functional group: gut flora stabilisers) for dairy cows. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There was no new evidence that would lead the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) to reconsider its previous conclusions on the safety of the product for the target species, consumers and the environment, for which the additive is considered to remain safe. Regarding user safety, the Panel reiterates its previous conclusions that the additive is not irritant to eyes and skin but should be considered a potential skin and respiratory sensitiser, and any exposure through skin and respiratory tract is considered a risk. There is no need for assessing the efficacy of the additive in the context of renewal of the authorisation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of the feed additives trans-anethole and eugenol for use in all avian species (ADISSEO, ADM, AGOLIN (Ireland) Ltd, Cargill, DSM Nutritional Products Ltd., LABORATORIES PHODE, Norel S.A.)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Maria de Lourdes Bastos,&nbsp;Paul Brantom,&nbsp;Andrew Chesson,&nbsp;Josef Schlatter,&nbsp;Johannes Westendorf,&nbsp;Maria Dulak-Lis,&nbsp;Paola Manini","doi":"10.2903/j.efsa.2025.9367","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9367","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 1-methoxy-4-(prop-1-(<i>trans</i>)-enyl)benzene (<i>trans</i>-anethole) and eugenol as sensory feed additives for all avian species. The additives are already authorised for use in all animal species except fish and poultry. The additives under assessment, <i>trans</i>-anethole (from either chemical synthesis or natural origin) and eugenol of natural origin, are considered of no safety concern for species (chickens and turkeys) for fattening and of being very unlikely to induce adverse effects in long-living and reproductive animals (laying hens) up to the maximum proposed use levels of 25 mg/kg complete feed. These conclusions are extrapolated to physiologically-related minor species. No safety concern would be expected for the consumer of animal products from the use of <i>trans</i>-anethole and eugenol up to the maximum proposed use level in feed. The use of <i>trans</i>-anethole and eugenol as feed additives is considered safe for the environment. Regarding user safety, <i>trans</i>-anethole is not irritant to skin and eyes but is a dermal sensitiser. Eugenol is irritant to skin and eyes and is a dermal sensitiser. When handling <i>trans</i>-anethole or eugenol, exposure of unprotected users to estragole or methyleugenol may occur. Therefore, to reduce the risk, the exposure of the users should be minimised. Since <i>trans</i>-anethole and eugenol are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of the existing maximum residue levels and setting of import tolerances for trifloxystrobin in various crops","authors":"European Food Safety Authority (EFSA),&nbsp;Giulia Bellisai,&nbsp;Giovanni Bernasconi,&nbsp;Luis Carrasco Cabrera,&nbsp;Irene Castellan,&nbsp;Monica del Aguila,&nbsp;Lucien Ferreira,&nbsp;Luna Greco,&nbsp;Samira Jarrah,&nbsp;Renata Leuschner,&nbsp;Andrea Mioč,&nbsp;Stefanie Nave,&nbsp;Hermine Reich,&nbsp;Silvia Ruocco,&nbsp;Alessia Pia Scarlato,&nbsp;Andrea Simonati,&nbsp;Marta Szot,&nbsp;Anne Theobald,&nbsp;Olha Timofieieva,&nbsp;Manuela Tiramani,&nbsp;Alessia Verani,&nbsp;Elena Zioga","doi":"10.2903/j.efsa.2025.9387","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9387","url":null,"abstract":"<p>In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer AG Crop Science Division submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue levels (MRLs) for trifloxystrobin in table olives, olives for oil production, celeries, globe artichokes, leeks, herbal infusions from flowers, leaves and herbs and seed spices. In addition, a request was submitted to set an import tolerance in linseeds based on authorised use of trifloxystrobin in Canada. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all the crops under assessment except for herbal infusion from flowers, leaves and herbs. Adequate analytical methods for enforcement are available to control the residues of trifloxystrobin on the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, European Food Safety Authority (EFSA) concluded that the short-term and long-term intake of residues resulting from the use of trifloxystrobin according to the reported agricultural practices is unlikely to present a risk to consumer health. The consumer risk assessment shall be regarded as indicative and affected by uncertainties.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a feed additive consisting of Kieselguhr (diatomaceous earth) for all animal species (Imerys France)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Vasileios Bampidis,&nbsp;Noël Dierick,&nbsp;Ruud Woutersen,&nbsp;Maria de Lourdes Bastos,&nbsp;Fernando Ramos,&nbsp;Jaume Galobart,&nbsp;Maria Vittoria Vettori,&nbsp;Orsolya Holczknecht,&nbsp;Jordi Ortuño,&nbsp;Fabiola Pizzo,&nbsp;Piera Valeri,&nbsp;Matteo L. Innocenti,&nbsp;Angelica Amaduzzi","doi":"10.2903/j.efsa.2025.9363","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9363","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Kieselguhr (diatomaceous earth, three forms: natural, purified calcined and purified flux-calcined) as a technological additive (functional group: anticaking and binder) for all animal species. Kieselguhr is predominantly amorphous silica (non-crystalline silicon dioxide (SiO₂)). Based on the information submitted, Kieselguhr natural, purified calcined and purified flux-calcined are safe when used at 5000 mg/kg of complete feed in all terrestrial animals. No conclusions can be reached on the safety of its use in aquatic animals. The use of Kieselguhr natural, purified calcined and purified flux-calcined in animal nutrition under the proposed conditions of use is safe for the consumer and the environment. Kieselguhr natural and purified flux-calcined are not irritant to the skin. All the three forms of the additive are irritant to the eyes and should be considered dermal and respiratory sensitisers. Any exposure is considered a risk. The FEEDAP Panel concluded that the additive is effective as a pellet binder. Kieselguhr is efficacious as an anticaking agent at a minimum concentration of 15,000 mg/kg.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian influenza overview December 2024–March 2025","authors":"European Food Safety Authority,&nbsp;European Centre for Disease Prevention and Control,&nbsp;European Union Reference Laboratory for Avian Influenza,&nbsp;Leonidas Alexakis,&nbsp;Hubert Buczkowski,&nbsp;Mariette Ducatez,&nbsp;Alice Fusaro,&nbsp;Jose L. Gonzales,&nbsp;Thijs Kuiken,&nbsp;Karl Ståhl,&nbsp;Christoph Staubach,&nbsp;Olov Svartström,&nbsp;Calogero Terregino,&nbsp;Katriina Willgert,&nbsp;Miguel Melo,&nbsp;Lisa Kohnle","doi":"10.2903/j.efsa.2025.9352","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9352","url":null,"abstract":"<p>Between 7 December 2024 and 7 March 2025, 743 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic (239) and wild (504) birds across 31 countries in Europe. HPAI A(H5N1) virus detections were predominant and mainly located in central, western and south-eastern Europe. Most HPAI A(H5) virus detections in wild birds concerned waterfowl, particularly mute swans, barnacle geese and greylag geese. Limited secondary spread was observed among the poultry outbreaks, and outdoor poultry access remained an important risk factor at the interface between wild and domestic birds. HPAI A(H5N5) outbreaks occurred only in wild birds and were increasingly reported in waterfowl. For the first time since spring 2024, several HPAI virus detections were reported in domestic cats and wild carnivores in Europe. In the United States of America (USA), the number of dairy cattle farms reportedly affected rose to almost 1000 in 17 States, and a different HPAI A(H5N1) virus genotype (D1.1) was reported in this species. Between 12 December 2024 and 7 March 2025, 22 new cases of avian influenza virus infection in humans were reported in the USA (12 A(H5) cases), Cambodia (two A(H5N1) cases), United Kingdom (one A(H5N1) case), and China (six A(H9N2) cases and one A(H10N3) case). Most of the A(H5) human cases (93%, <i>n</i> = 14/15) had reported exposure to poultry or dairy cattle prior to avian influenza virus detection or onset of illness. Considering the widespread circulation of avian influenza viruses in animal populations, human infections with avian influenza viruses remain infrequent. No evidence of human-to-human transmission has been documented during the reporting period. The risk of infection with the avian A(H5) influenza viruses of clade 2.3.4.4b currently circulating in Europe remains low for the general public in the European Union/European Economic Area (EU/EEA). The risk of infection remains low-to-moderate for those occupationally or otherwise exposed to infected animals or contaminated environments.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the feed additive consisting of a strain belonging to Eggerthellaceae family (DSM 11798) for pigs and all avian species (1m01) for the renewal of its authorisation (BIOMIN GmbH)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Baltasar Mayo,&nbsp;Montserrat Anguita,&nbsp;Jaume Galobart,&nbsp;Jordi Ortuño,&nbsp;Fabiola Pizzo,&nbsp;Rosella Brozzi","doi":"10.2903/j.efsa.2025.9360","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9360","url":null,"abstract":"<p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of the authorisation of the preparation containing viable cells of the bacterium DSM 11798 intended for use as a technological additive (functional group: substances for reduction of the contamination of feed by mycotoxins) in feed for pigs and all avian species. The applicant provided evidence that the additive currently on the market complies with the existing terms of the authorisation. The identification of the active agent has been changed and it belongs to the <i>Eggerthellaceae</i> family. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive remains safe for piglets, pigs for fattening and all avian species, consumers and the environment under the approved terms of the authorisation. Regarding user safety, the additive is not a skin or eye irritant. However, it should be considered a skin and respiratory sensitiser, and any exposure through the skin and respiratory tract is a risk. This conclusion would apply, in principle, to any preparation containing the active agent. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a feed additive consisting of guanidinoacetic acid (Creamino®) for turkeys for fattening and reared for breeding (Alzchem Trostberg GmbH)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Jaume Galobart,&nbsp;Jordi Ortuño Casanova,&nbsp;Maria Vittoria Vettori,&nbsp;Jordi Tarrés-Call,&nbsp;Alberto Navarro-Villa","doi":"10.2903/j.efsa.2025.9349","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9349","url":null,"abstract":"<p>Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) when used as zootechnical additive in feed and water for drinking for turkeys for fattening and turkeys reared for breeding, and a preparation of GAA when used in feed for the same target species. The FEEDAP Panel concluded that GAA at 1200 mg/kg complete feed or 600 mg/L water is safe for turkeys for fattening and turkeys reared for breeding. There is no concern on consumer safety resulting from the use of GAA for turkeys at the proposed conditions of use. GAA is not toxic by inhalation, not irritant to skin and eyes and not a dermal sensitiser. The FEEDAP Panel concluded that the use of GAA as feed additive is not expected to pose a risk to the environment. The use of the additive under assessment in animal nutrition at the proposed conditions of use has the potential to be efficacious in turkeys for fattening and turkeys reared for breeding. The above conclusions apply to both the active substance GAA and the preparation of GAA.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of the feed additive consisting of clinoptilolite of sedimentary origin for all animal species for the renewal of its authorisation (ZEOCEM, a.s.)","authors":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),&nbsp;Roberto Edoardo Villa,&nbsp;Giovanna Azimonti,&nbsp;Eleftherios Bonos,&nbsp;Henrik Christensen,&nbsp;Mojca Durjava,&nbsp;Birgit Dusemund,&nbsp;Ronette Gehring,&nbsp;Boet Glandorf,&nbsp;Maryline Kouba,&nbsp;Marta López-Alonso,&nbsp;Francesca Marcon,&nbsp;Carlo Nebbia,&nbsp;Alena Pechová,&nbsp;Miguel Prieto-Maradona,&nbsp;Ilen Röhe,&nbsp;Katerina Theodoridou,&nbsp;Jaume Galobart,&nbsp;Orsolya Holczknecht,&nbsp;Fabiola Pizzo,&nbsp;Anita Radovnikovic,&nbsp;Maria Vittoria Vettori,&nbsp;Angelica Amaduzzi","doi":"10.2903/j.efsa.2025.9364","DOIUrl":"https://doi.org/10.2903/j.efsa.2025.9364","url":null,"abstract":"<p>Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of clinoptilolite of sedimentary origin as a technological feed additive (binder and anticaking agents) for all animal species. The applicant provided evidence that the additive currently on the market complies with the existing conditions of authorisation. The Panel concludes that clinoptilolite of sedimentary origin remains safe for all animal species, consumers and the environment under the authorised conditions of use. Regarding user safety, the additive is not a skin nor an eye irritant but should be considered a skin and respiratory sensitiser. Inhalation and dermal exposure are considered a risk. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"23 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2025.9364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}