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Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus subtilis strain Glu3-3. 转基因枯草芽孢杆菌Glu3-3食品谷氨酰胺酶的安全性评价。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-05-06 eCollection Date: 2026-05-01 DOI: 10.2903/j.efsa.2026.10088
Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L M Solano, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu
{"title":"Safety evaluation of the food enzyme glutaminase from the genetically modified <i>Bacillus subtilis</i> strain Glu3-3.","authors":"Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L M Solano, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu","doi":"10.2903/j.efsa.2026.10088","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10088","url":null,"abstract":"<p><p>The food enzyme glutaminase (l-glutamine amidohydrolase; EC 3.5.1.2) is produced with the genetically modified <i>Bacillus subtilis</i> strain Glu3-3 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of acquired antimicrobial resistance genes. The food enzyme was considered free of viable cells of the production strain, but the absence of DNA was not demonstrated. As no other concerns arising from the microbial source or from the manufacturing process have been identified, the Panel considered that toxicological tests are not needed for the assessment of this food enzyme. The food enzyme is intended to be used in seven food manufacturing processes. Dietary exposure was estimated to be up to 29.311 mg total organic solids/kg body weight per day in European populations. A search for the homology of the amino acid sequence of the glutaminase to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure cannot be excluded, but that the likelihood is low. Because the absence of DNA from the production organism in the food enzyme was not demonstrated, the Panel could not conclude on the safety of the food enzyme.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 5","pages":"e10088"},"PeriodicalIF":3.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated safety evaluation of the food enzyme catalase from the non-genetically modified Aspergillus tubingensis strain AE-CN. 非转基因塔宾曲霉AE-CN食品酶过氧化氢酶的安全性评价
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-05-06 eCollection Date: 2026-05-01 DOI: 10.2903/j.efsa.2026.10082
Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L M Solano, Henk Van Loveren, Laurence Vernis, Simone Lunardi, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Criado, Yi Liu
{"title":"Updated safety evaluation of the food enzyme catalase from the non-genetically modified <i>Aspergillus tubingensis</i> strain AE-CN.","authors":"Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L M Solano, Henk Van Loveren, Laurence Vernis, Simone Lunardi, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Criado, Yi Liu","doi":"10.2903/j.efsa.2026.10082","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10082","url":null,"abstract":"<p><p>The food enzyme catalase (hydrogen-peroxide:hydrogen-peroxide oxidoreductase; EC 1.11.1.6) is produced with the non-genetically modified <i>Aspergillus tubingensis</i> strain AE-CN by Amano Enzyme Inc. The food enzyme is intended to be used in seven food manufacturing processes. In a previous evaluation, the Panel could not conclude on the safety of this food enzyme due to uncertainties about the absence of viable cells of the production organism in the food enzyme and to the clastogenic effects observed in the in vitro genotoxicity studies, which could not be dismissed due to limitations in the in vivo studies. In this assessment, the Panel evaluated new data provided by the applicant and completed the safety evaluation of this food enzyme. The new data demonstrated the absence of viable cells of the production organism in the food enzyme and showed no concerns on genotoxicity. Based on the new data provided and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 5","pages":"e10082"},"PeriodicalIF":3.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2024 European Union report on pesticide residues in food. 2024年欧盟关于食品中农药残留的报告。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-05-05 eCollection Date: 2026-05-01 DOI: 10.2903/j.efsa.2026.10054
Paula Medina Pastor, Luis Carrasco Cabrera, Giulio Di Piazza, Carmen González Ciria
{"title":"The 2024 European Union report on pesticide residues in food.","authors":"Paula Medina Pastor, Luis Carrasco Cabrera, Giulio Di Piazza, Carmen González Ciria","doi":"10.2903/j.efsa.2026.10054","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10054","url":null,"abstract":"<p><p>Under European Union legislation (Article 32, Regulation (EC) No 396/2005), the European Food Safety Authority publishes an annual report assessing pesticide residue levels in food. In 2024, 9842 samples were analysed as part of the EU-coordinated multiannual control programme subset, of which 1.2% were found to be non-compliant. National sampling procedures were used in 86,449 samples where the non-compliant rate was 1.8%. Increased import control programme accounted for 39,433 samples with a 3.6% non-compliant rate. Acute and chronic dietary exposure was estimated by providing the probabilities of exceeding the health-based guidance values (HBGV) for the pesticide residues in food. Overall, the estimated dietary risk was found to be low for most of the EU subpopulation groups and assessed substances. Recommendations are provided to risk managers to increase the effectiveness of European control systems and to ensure a high level of consumer protection throughout the EU.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 5","pages":"e10054"},"PeriodicalIF":3.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of acute exposure to the food additive glycerol (E 422) from beverages. 急性暴露于饮料中食品添加剂甘油(e422)的安全性。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-05-05 eCollection Date: 2026-05-01 DOI: 10.2903/j.efsa.2026.10057
Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl-Kraupp, Ursula Gundert-Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Dominique Turk, Matthew Wright, Consuelo Civitella, Petra Gergelova, Alessandra Tosato, Ana Maria Rincon
{"title":"Safety of acute exposure to the food additive glycerol (E 422) from beverages.","authors":"Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl-Kraupp, Ursula Gundert-Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Dominique Turk, Matthew Wright, Consuelo Civitella, Petra Gergelova, Alessandra Tosato, Ana Maria Rincon","doi":"10.2903/j.efsa.2026.10057","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10057","url":null,"abstract":"<p><p>The European Commission requested EFSA to assess the acute exposure to glycerol (E 422) from slush ice drinks and de-alcoholised wine. The acute exposure assessment was conducted on a single‑consumption‑event basis considering the reported use levels and analytical data of glycerol in slush ice drinks and the proposed maximum level of 50,000 mg glycerol/L in de-alcoholised wine. The Panel considered that a conservative dose above which unintended pharmacological effects would occur should be used for the determination of the acute reference dose (ARfD). Based on Wald and McLaurin (1982) study, the Panel derived an ARfD of 125 mg glycerol/kg body weight for a single consumption event. The Panel concluded that the acute exposure to glycerol per single consumption event from slush ice drinks, assuming a consumption of 250 mL and 500 mL for children and other population groups, respectively, would exceed the ARfD for all population groups. The Panel also concluded that the P95 acute exposure estimates for glycerol, at the proposed maximum level, from the potential use of de‑alcoholised wine, assumed to be consumed by children and adolescents as a substitute for flavoured drinks and by other population groups as a substitute for wine and wine-like drinks, would exceed the ARfD for all population groups. As requested by the European Commission, the Panel calculated the maximum single consumption event volume of beverages containing E 422 that can be consumed by different populations groups without exceeding the ARfD. The Panel also calculated the theoretical maximum levels of E 422 when used as a food additive in beverages, including slush ice drinks and de-alcoholised wine, at which exposure does not exceed the ARfD in different population groups. The Panel recommends the European Commission to consider establishing numerical maximum levels for glycerol (E 422) when used in beverages.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 5","pages":"e10057"},"PeriodicalIF":3.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavouring Group Evaluation 82 Revision 2 (FGE.82Rev2): Consideration of epoxides evaluated by JECFA. 调味类评价82修订2 (FGE.82Rev2):考虑由JECFA评价的环氧化物。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-30 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10055
Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, María José Frutos Fernández, Bettina Grasl-Kraupp, Ursula Gundert-Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Gisela Degen, Karl-Heinz Engel, Maria Carfí, Ana Criado, Borana Dino, Carla Martino
{"title":"Flavouring Group Evaluation 82 Revision 2 (FGE.82Rev2): Consideration of epoxides evaluated by JECFA.","authors":"Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, María José Frutos Fernández, Bettina Grasl-Kraupp, Ursula Gundert-Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Gisela Degen, Karl-Heinz Engel, Maria Carfí, Ana Criado, Borana Dino, Carla Martino","doi":"10.2903/j.efsa.2026.10055","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10055","url":null,"abstract":"<p><p>The Panel on Food Additives and Flavourings (FAF) of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No. 1565/2000. The present consideration concerns a group of five epoxides evaluated by JECFA at the 65th meeting. This revision of FGE.82 is made due to new information on stereoisomeric composition, toxicity studies, uses and use levels for beta-ionone epoxide [FL-no: 07.170]. In addition, new data on uses and use levels for the substances [FL-no: 16.015, 16.018, 16.040 and 16.043] have been provided and considered for the estimation of exposure (modified theoretical added maximum daily intake (mTAMDI) approach). The Panel considered that the information on the stereochemical composition of [FL-no: 07.170] is sufficient. The Panel did not agree with the application of the Procedure for the epoxides as performed by JECFA, because in the absence of experimental data, the extent of detoxification of these epoxides remains uncertain. Therefore, [FL-no: 07.170] was assessed via the B-side of the Procedure. In the 90-day toxicity study on [FL-no: 07.170], substance-related findings were observed in adrenal glands of male rats. Based on this observation, the Panel identified a no observed adverse effect level (NOAEL) of 39 mg/kg bw per day and concluded that for [FL-no: 07.170] there is 'no safety concern at estimated levels of intake as flavouring substance', when based on the maximised survey-derived daily intake (MSDI) approach. Based on new information on uses and use levels for [FL-no: 07.170, 16.015, 16.018, 16.040 and 16.043], the mTAMDI exposure estimates are above the toxicological threshold of concern (TTC) for their structural class III. The Panel concluded that more reliable data on uses and use levels would be needed for these five substances.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10055"},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of a feed additive consisting of vitamin B12 (cyanocobalamin) produced by fermentation with Ensifer adhaerensCCTCC M 20241585 for all animal species (Orffa Additives B.V.). 用Ensifer adhaerensCCTCC M 20241585发酵生产的含维生素B12(氰钴胺素)的饲料添加剂的安全性和有效性(Orffa Additives B.V.)。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-30 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10049
Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Katerina Theodoridou, Pier Sandro Cocconcelli, Elisa Pettenati, Jaume Galobart, Maria Vittoria Vettori, Piera Valeri
{"title":"Safety and efficacy of a feed additive consisting of vitamin B<sub>12</sub> (cyanocobalamin) produced by fermentation with <i>Ensifer adhaerens</i>CCTCC M 20241585 for all animal species (Orffa Additives B.V.).","authors":"Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Katerina Theodoridou, Pier Sandro Cocconcelli, Elisa Pettenati, Jaume Galobart, Maria Vittoria Vettori, Piera Valeri","doi":"10.2903/j.efsa.2026.10049","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10049","url":null,"abstract":"<p><p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B<sub>12</sub> (cyanocobalamin) produced by fermentation with <i>Ensifer adhaerens</i> CCTCC M 20241585, when used as a nutritional additive for all animal species. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the origin and history of modification of the production strain <i>E. adhaerens</i> CCTCC M 20241585. Although DNA of the production strain was not detected in the product, uncertainties remain regarding the possible presence of its viable cells. Considering the uncertainties on the origin of the cyanocobalamin production strain CTCC M 20241585 and on the possible presence of its viable cells in the additive, the Panel could not conclude on the safety of the additive for the target species, consumer, users and the environment. Cyanocobalamin produced by fermentation with <i>E. adhaerens</i> CCTCC M 20241585 is effective in meeting animal's nutritional requirements when administered via feed.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10049"},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of a feed additive consisting of l-arginine produced with Corynebacterium glutamicumCCTCC M 20232577 for all animal species (Dongxiao Biotechnology Co., Ltd.). 谷氨酰胺棒状杆菌cctcc M 20232577生产的l-精氨酸饲料添加剂对所有动物的安全性和有效性(东晓生物科技有限公司)。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-29 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10074
Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Katerina Theodoridou, Montserrat Anguita, Nicole Bozzi Cionci, Rafaella Christodoulou, Matteo L Innocenti, Maria Kolona, Elisa Pettenati, Jordi Tarrés-Call, Yolanda García-Cazorla
{"title":"Safety and efficacy of a feed additive consisting of l-arginine produced with <i>Corynebacterium glutamicum</i>CCTCC M 20232577 for all animal species (Dongxiao Biotechnology Co., Ltd.).","authors":"Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López-Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto-Maradona, Katerina Theodoridou, Montserrat Anguita, Nicole Bozzi Cionci, Rafaella Christodoulou, Matteo L Innocenti, Maria Kolona, Elisa Pettenati, Jordi Tarrés-Call, Yolanda García-Cazorla","doi":"10.2903/j.efsa.2026.10074","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10074","url":null,"abstract":"<p><p>Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-arginine produced by fermentation with <i>Corynebacterium glutamicum</i> CCTCC M 20232577 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain is non-genetically modified and viable cells of the production strain were not detected in the final product. The use of l-arginine produced with <i>C. glutamicum</i> CCTCC M 20232577 in feed is safe for the target species when supplemented in appropriate amounts to the diet according to their nutritional needs. The FEEDAP Panel has concerns on the use of l-arginine in water for drinking. The use of l-arginine (≥ 98.5%) produced with <i>C. glutamicum</i> CCTCC M 20232577 in animal nutrition is considered safe for the consumers and for the environment. Regarding the safety for the user, owing to the lack of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin and/or eyes and to be a potential skin sensitiser. The additive is regarded as an effective source of the amino acid l-arginine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10074"},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2024 European Union monitoring report on food additives and flavourings (1st pilot). 2024年欧盟食品添加剂和调味料监测报告(第一次试点)。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-29 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10070
Bruno Dujardin, José Ángel Gómez Ruiz, Sofia Ioannidou, Stefania Salvatore, Camilla Smeraldi, Alexandra Tard, Alicia Gutiérrez Linares
{"title":"The 2024 European Union monitoring report on food additives and flavourings (1st pilot).","authors":"Bruno Dujardin, José Ángel Gómez Ruiz, Sofia Ioannidou, Stefania Salvatore, Camilla Smeraldi, Alexandra Tard, Alicia Gutiérrez Linares","doi":"10.2903/j.efsa.2026.10070","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10070","url":null,"abstract":"<p><p>This EFSA report presents the results of the 2024 European Union (EU) pilot monitoring programme on food additives and flavourings, in response to a mandate from the European Commission. This pilot focused on three food additives, green S (E 142), ponceau 4R (E 124) and tartrazine (E 102), and two flavourings, caffeine (FL No 16.016) and pulegone (Annex III of Regulation (EC) No 1334/2008). The aim of the monitoring programme is to evaluate the occurrence and use of these substances, estimate chronic dietary exposure across population groups and compare the outcomes with previous EFSA assessments. Monitoring data were collected from 22 EU Member States and five food business operators, comprising 18,296 analytical results from 8943 food samples and 663 use levels. Dietary exposure was assessed using three refined exposure scenarios: non-brand-loyal, brand-loyal and food-supplement 'consumers only' scenarios. For the three food additives, all exposure estimates were well below their respective acceptable daily intakes (ADIs). For pulegone, exposure estimates were below the tolerable daily intake (TDI). For caffeine, as already reported in previous EFSA assessments, exposure estimates in several dietary surveys exceeded doses of no safety concern, particularly in adults and the elderly, largely driven by the consumption of foods with naturally occurring caffeine such as coffee and tea rather than foods with added caffeine. Caffeine exposure was higher as compared with previous assessments; the current estimates are considered as largely overestimated due to some limitations in the concentration data and the methodology used in the assessment. Overall, different challenges and misreporting were identified when preparing the monitoring report that might have biased, to different extents, the dietary exposure estimations for the substances assessed. Therefore, conclusions derived in the framework of this first pilot are not yet considered to be sufficiently robust for decision-making, and further actions will be taken to strengthen the collection and analysis of the monitoring data in the next report.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10070"},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible alignment of the EU BSE surveillance with the new WOAH provisions. 欧盟疯牛病监测可能与新的世界卫生组织规定保持一致。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-27 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10044
Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Anja B Riber, Karl Stahl, Jan Arend Stegeman, Hans-Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mark Arnold, Christian Ducrot, John Griffin, Giuseppe Ru, Marion Simmons, Sean Ashe, Angel Ortiz- Pelaez, Kamela Kryemadhi, Romolo Nonno
{"title":"Possible alignment of the EU BSE surveillance with the new WOAH provisions.","authors":"Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Anja B Riber, Karl Stahl, Jan Arend Stegeman, Hans-Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mark Arnold, Christian Ducrot, John Griffin, Giuseppe Ru, Marion Simmons, Sean Ashe, Angel Ortiz- Pelaez, Kamela Kryemadhi, Romolo Nonno","doi":"10.2903/j.efsa.2026.10044","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10044","url":null,"abstract":"<p><p>The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C-, H- and L-type) in the European Union (EU) and to propose if any current EU surveillance provisions should be kept. The WOAH provisions stipulate that BSE surveillance should target animals on the BSE clinical spectrum and require the implementation of standardised clinical protocols for selecting animals for testing. Based on expert judgement of retrospective clinical data, between 5% and 49% of the 55 BSE cases detected in the EU & UK since 2015 would have been selected for testing by the WOAH surveillance. Assuming the current EU surveillance, a back-calculation model predicted a very low number of BSE cases detected for the period 2025-2029: 0.0196 for C-BSE, 10.94 for H-BSE and 9.13 for L-BSE. As no classical BSE (C-BSE) cases are expected, the application of the WOAH provisions would primarily impact the detection of atypical BSE (H-BSE and L-BSE), with an estimated detection over the next 5 years of between zero and five H-BSE cases and between zero and four L-BSE cases. Supplementing the WOAH provisions with systematic testing of fallen stock (with or without emergency slaughter) with increased age threshold of 60 or 72 months would achieve a detection capability close to current EU levels. This approach would enable the documentation of the effectiveness of BSE control measures, provide scientific assurance that the decline in C-BSE is sustained and allow atypical BSE trends to be monitored reliably while maintaining the sensitivity required to detect any re-emergence of C-BSE. Finally, this would contribute to risk mitigation by triggering immediate statutory control measures when cases are detected. Modifications of EU surveillance requirements should consider any potential adjustments to other available BSE control measures.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10044"},"PeriodicalIF":3.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commodity risk assessment of Robinia pseudoacacia plants from the United Kingdom. 英国刺槐植物的商品风险评估。
IF 3.3 3区 农林科学
EFSA Journal Pub Date : 2026-04-22 eCollection Date: 2026-04-01 DOI: 10.2903/j.efsa.2026.10056
Antonio Vicent Civera, Paula Baptista, Anna Berlin, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de la Peña, Nicolas Desneux, Francesco Di Serio, Anna Filipiak, Paolo Gonthier, Beata Hasiów-Jaroszewska, Hervé Jactel, Blanca B Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T Papadopoulos, Hanna Susi, Dirk Jan van der Gaag, Jane Debode, Juan A Navas-Cortes, Christos Kritikos, Maria Kormpi, Dimitrios Papachristos, Chrysavgi Reppa, Antigoni Akrivou, Spyridon Antonatos, Despoina Beris, Olaf Mosbach Schulz, Monia Federica Lombardo, Ciro Gardi, Roel Potting
{"title":"Commodity risk assessment of <i>Robinia pseudoacacia</i> plants from the United Kingdom.","authors":"Antonio Vicent Civera, Paula Baptista, Anna Berlin, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de la Peña, Nicolas Desneux, Francesco Di Serio, Anna Filipiak, Paolo Gonthier, Beata Hasiów-Jaroszewska, Hervé Jactel, Blanca B Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T Papadopoulos, Hanna Susi, Dirk Jan van der Gaag, Jane Debode, Juan A Navas-Cortes, Christos Kritikos, Maria Kormpi, Dimitrios Papachristos, Chrysavgi Reppa, Antigoni Akrivou, Spyridon Antonatos, Despoina Beris, Olaf Mosbach Schulz, Monia Federica Lombardo, Ciro Gardi, Roel Potting","doi":"10.2903/j.efsa.2026.10056","DOIUrl":"https://doi.org/10.2903/j.efsa.2026.10056","url":null,"abstract":"<p><p>The European Commission requested the EFSA Panel on Plant Health (PLH) to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as 'High risk plants, plant products and other objects'. This Scientific Opinion covers plant health risks posed by rooted plants in pots of <i>Robinia pseudoacacia</i> 'Frisia' imported from the United Kingdom (UK). The assessment was performed considering the available scientific information, including the technical information provided by the UK. All pests potentially associated with the commodity were evaluated against specific criteria. Two EU-regulated pests (<i>Bemisia tabaci</i> and <i>Phytophthora ramorum</i> non-EU isolates), present in the UK and potentially associated with the commodity, were considered as relevant for this Opinion. No non-regulated pests in the European Union were identified to be selected for further evaluation.</p>","PeriodicalId":11657,"journal":{"name":"EFSA Journal","volume":"24 4","pages":"e10056"},"PeriodicalIF":3.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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